HIST1H3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome assembly (GO:0006335)8.76988113
2DNA replication-dependent nucleosome organization (GO:0034723)8.76988113
3chromatin assembly (GO:0031497)7.87022009
4regulation of histone H3-K9 methylation (GO:0051570)7.38681265
5nucleosome assembly (GO:0006334)6.38802816
6nuclear pore complex assembly (GO:0051292)6.16296872
7nuclear pore organization (GO:0006999)6.05656430
8DNA unwinding involved in DNA replication (GO:0006268)5.87874081
9chromatin assembly or disassembly (GO:0006333)5.69272546
10nucleosome organization (GO:0034728)5.60305968
11mitotic chromosome condensation (GO:0007076)5.46362808
12protein localization to kinetochore (GO:0034501)5.46069108
13protein-DNA complex assembly (GO:0065004)5.37582749
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.11242558
15antibacterial humoral response (GO:0019731)4.91156967
16sister chromatid segregation (GO:0000819)4.88853252
17protein-DNA complex subunit organization (GO:0071824)4.87869298
18folic acid-containing compound biosynthetic process (GO:0009396)4.66895845
19protein localization to chromosome, centromeric region (GO:0071459)4.66196531
20pore complex assembly (GO:0046931)4.65315554
21innate immune response in mucosa (GO:0002227)4.60324677
22antimicrobial humoral response (GO:0019730)4.56966040
23regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.37581562
24negative regulation of histone methylation (GO:0031061)4.32201822
25mitotic sister chromatid segregation (GO:0000070)4.28053743
26DNA replication initiation (GO:0006270)4.25973203
27chromatin remodeling at centromere (GO:0031055)4.20082336
28mitotic nuclear envelope disassembly (GO:0007077)4.13936911
29CENP-A containing nucleosome assembly (GO:0034080)4.13026977
30regulation of gene silencing (GO:0060968)4.11454335
31DNA duplex unwinding (GO:0032508)4.09750239
32DNA geometric change (GO:0032392)4.08463229
33IMP biosynthetic process (GO:0006188)4.06432455
34regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.01712360
35membrane disassembly (GO:0030397)3.95072637
36nuclear envelope disassembly (GO:0051081)3.95072637
37positive regulation of chromosome segregation (GO:0051984)3.87941983
38regulation of centriole replication (GO:0046599)3.86669468
39dosage compensation (GO:0007549)3.86330563
40regulation of sister chromatid cohesion (GO:0007063)3.85031564
41mitotic sister chromatid cohesion (GO:0007064)3.84063087
42regulation of posttranscriptional gene silencing (GO:0060147)3.80095523
43regulation of gene silencing by miRNA (GO:0060964)3.80095523
44regulation of gene silencing by RNA (GO:0060966)3.80095523
45positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.77614752
46positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.77614752
47positive regulation of mitotic sister chromatid separation (GO:1901970)3.77614752
48DNA strand elongation involved in DNA replication (GO:0006271)3.77162113
49DNA replication-independent nucleosome organization (GO:0034724)3.73446846
50DNA replication-independent nucleosome assembly (GO:0006336)3.73446846
51protein K6-linked ubiquitination (GO:0085020)3.65074418
52chromosome condensation (GO:0030261)3.64775309
53V(D)J recombination (GO:0033151)3.64467442
54DNA replication checkpoint (GO:0000076)3.61672301
55IMP metabolic process (GO:0046040)3.59986338
56kinetochore organization (GO:0051383)3.59784804
57regulation of translational fidelity (GO:0006450)3.59215615
58double-strand break repair via nonhomologous end joining (GO:0006303)3.59009255
59non-recombinational repair (GO:0000726)3.59009255
60DNA strand elongation (GO:0022616)3.56565231
61viral mRNA export from host cell nucleus (GO:0046784)3.55902306
62regulation of centrosome cycle (GO:0046605)3.54692023
63mitotic recombination (GO:0006312)3.52975885
64DNA topological change (GO:0006265)3.51844165
65histone exchange (GO:0043486)3.46660769
66mucosal immune response (GO:0002385)3.46209842
67defense response to Gram-positive bacterium (GO:0050830)3.44944712
68translesion synthesis (GO:0019985)3.44660091
69positive regulation of histone methylation (GO:0031062)3.44157064
70telomere maintenance via semi-conservative replication (GO:0032201)3.43253212
71regulation of RNA export from nucleus (GO:0046831)3.38227791
72attachment of spindle microtubules to kinetochore (GO:0008608)3.37120729
73pre-miRNA processing (GO:0031054)3.35426887
74DNA conformation change (GO:0071103)3.34896382
75regulation of spindle organization (GO:0090224)3.33524535
76negative regulation of chromosome segregation (GO:0051985)3.32462269
77telomere organization (GO:0032200)3.32167910
78regulation of DNA endoreduplication (GO:0032875)3.31663331
79negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.29850907
80regulation of chromosome segregation (GO:0051983)3.28032443
81organ or tissue specific immune response (GO:0002251)3.26072858
82meiotic chromosome segregation (GO:0045132)3.25057202
83viral transcription (GO:0019083)3.24349350
84regulation of centrosome duplication (GO:0010824)3.24265390
85DNA ligation (GO:0006266)3.23894187
86ATP-dependent chromatin remodeling (GO:0043044)3.23148084
87telomere maintenance via telomere lengthening (GO:0010833)3.21883975
88protein localization to chromosome (GO:0034502)3.21015505
89mitotic metaphase plate congression (GO:0007080)3.20631005
90translational termination (GO:0006415)3.20289226
91postreplication repair (GO:0006301)3.18411593
92regulation of helicase activity (GO:0051095)3.17212966
93telomere maintenance via recombination (GO:0000722)3.16087788
94regulation of mitotic sister chromatid separation (GO:0010965)3.15356751
95regulation of mitotic sister chromatid segregation (GO:0033047)3.15356751
96regulation of sister chromatid segregation (GO:0033045)3.15356751
97maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.15073870
98DNA packaging (GO:0006323)3.13630308
99regulation of mitotic spindle organization (GO:0060236)3.12300628
100metaphase plate congression (GO:0051310)3.11072265
101spindle checkpoint (GO:0031577)3.09168155
102somatic hypermutation of immunoglobulin genes (GO:0016446)3.08615064
103somatic diversification of immune receptors via somatic mutation (GO:0002566)3.08615064
104positive regulation of cell cycle checkpoint (GO:1901978)3.08590094
105regulation of megakaryocyte differentiation (GO:0045652)3.06077652
106nucleobase biosynthetic process (GO:0046112)3.05735880
107negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.05010290
108negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.05010290
109negative regulation of mitotic sister chromatid segregation (GO:0033048)3.05010290
110negative regulation of mitotic sister chromatid separation (GO:2000816)3.05010290
111negative regulation of sister chromatid segregation (GO:0033046)3.05010290
112mitotic spindle assembly checkpoint (GO:0007094)3.04764166
113regulation of mitotic metaphase/anaphase transition (GO:0030071)3.03860795
114protoporphyrinogen IX metabolic process (GO:0046501)3.03799281
115regulation of histone methylation (GO:0031060)3.02269865
116DNA synthesis involved in DNA repair (GO:0000731)3.02252308
117regulation of translational termination (GO:0006449)3.02055119
118chromosome segregation (GO:0007059)3.01298262
119heterochromatin organization (GO:0070828)3.01159643
120ribosomal small subunit assembly (GO:0000028)2.97063122
121nuclear envelope organization (GO:0006998)2.96961481
122nucleotide-excision repair, DNA gap filling (GO:0006297)2.96710088
123protoporphyrinogen IX biosynthetic process (GO:0006782)2.96340228
124spindle assembly checkpoint (GO:0071173)2.96233616
125regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.95446787
126telomere maintenance (GO:0000723)2.93643543
127proline biosynthetic process (GO:0006561)2.93588216
128mitotic spindle checkpoint (GO:0071174)2.92413829
129mitotic G1 DNA damage checkpoint (GO:0031571)2.90738002
130replication fork processing (GO:0031297)2.89551165

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.23445349
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.81265932
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.34254712
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.33815871
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.15803457
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.11481661
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58944683
8* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.32924944
9* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26172863
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.23252596
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.18770641
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.17371904
13GATA1_22025678_ChIP-Seq_K562_Human2.13142259
14* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02585613
15SOX2_16153702_ChIP-ChIP_HESCs_Human2.01389974
16* FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse14.4722754
17EGR1_19374776_ChIP-ChIP_THP-1_Human1.83444754
18* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.83154734
19* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.82571109
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.80194863
21MYC_19079543_ChIP-ChIP_MESCs_Mouse1.70112194
22* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.69280601
23SOX2_18555785_ChIP-Seq_MESCs_Mouse1.67742540
24AR_21909140_ChIP-Seq_LNCAP_Human1.65457607
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62278866
26IRF1_19129219_ChIP-ChIP_H3396_Human1.61954893
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61150755
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.59157158
29ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57076985
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50698214
31* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50554913
32* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44490484
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.40480608
34TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38050744
35HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.36340393
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34046243
37VDR_23849224_ChIP-Seq_CD4+_Human1.33234291
38* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32915985
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29721729
40KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27342172
41ELK1_19687146_ChIP-ChIP_HELA_Human1.26712449
42ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26182634
43MYC_22102868_ChIP-Seq_BL_Human1.26054102
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24415440
45* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22705465
46NANOG_16153702_ChIP-ChIP_HESCs_Human1.22683730
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21028417
48TCF3_18692474_ChIP-Seq_MESCs_Mouse1.20938402
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20120470
50* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.12968772
51DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11986711
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11621781
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10736911
54XRN2_22483619_ChIP-Seq_HELA_Human1.07784035
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06381714
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05049361
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04509649
58ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03482857
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02969120
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02625270
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99874814
62FOXP3_21729870_ChIP-Seq_TREG_Human0.98533112
63MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96169189
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94558121
65* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93667744
66CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92293517
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91727321
68ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90399671
69VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88697845
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87887429
71NOTCH1_21737748_ChIP-Seq_TLL_Human0.87638556
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.86702590
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85286307
74* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84815063
75CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84264490
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.83278951
77PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83228196
78THAP11_20581084_ChIP-Seq_MESCs_Mouse0.81306534
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80652657
80* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80345136
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.79591129
82VDR_21846776_ChIP-Seq_THP-1_Human0.79578625
83* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.79578220
84MAF_26560356_Chip-Seq_TH1_Human0.78435246
85NANOG_21062744_ChIP-ChIP_HESCs_Human0.76705827
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.75689427
87EST1_17652178_ChIP-ChIP_JURKAT_Human0.75245774
88ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74884933
89ELF1_17652178_ChIP-ChIP_JURKAT_Human0.74325633
90* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.74191068
91CIITA_25753668_ChIP-Seq_RAJI_Human0.72537806
92STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.72532636
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72429629
94TTF2_22483619_ChIP-Seq_HELA_Human0.72174386
95ZNF263_19887448_ChIP-Seq_K562_Human0.72094206
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71277006
97KDM5A_27292631_Chip-Seq_BREAST_Human0.70056315
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.69980771
99POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.68552372
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.68487088
101* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.68191475
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.66717496
103TP63_17297297_ChIP-ChIP_HaCaT_Human0.66245474
104ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.66009203
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.65835687
106NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.65705889
107SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.65500397
108ETS1_20019798_ChIP-Seq_JURKAT_Human0.65395726
109HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.64654882
110MYC_18940864_ChIP-ChIP_HL60_Human0.64607441
111TP63_19390658_ChIP-ChIP_HaCaT_Human0.64550653
112TCF3_18692474_ChIP-Seq_MEFs_Mouse0.61678368
113KLF4_18555785_ChIP-Seq_MESCs_Mouse0.61538737
114* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.61426231
115GATA2_22383799_ChIP-Seq_G1ME_Mouse0.60848723
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.60751718
117SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.59879519
118DCP1A_22483619_ChIP-Seq_HELA_Human0.58063352

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.68351702
2MP0003111_abnormal_nucleus_morphology4.09310200
3MP0010307_abnormal_tumor_latency3.92362509
4MP0003077_abnormal_cell_cycle3.67585776
5MP0003693_abnormal_embryo_hatching3.55684075
6MP0010352_gastrointestinal_tract_polyps3.26606080
7MP0004957_abnormal_blastocyst_morpholog3.26537486
8MP0008057_abnormal_DNA_replication3.02529404
9MP0003705_abnormal_hypodermis_morpholog2.93909665
10MP0003123_paternal_imprinting2.63332919
11MP0010234_abnormal_vibrissa_follicle2.60581534
12MP0008058_abnormal_DNA_repair2.50293298
13MP0005076_abnormal_cell_differentiation2.42662997
14MP0000350_abnormal_cell_proliferation2.34771024
15MP0006054_spinal_hemorrhage2.33341102
16MP0001730_embryonic_growth_arrest2.32817562
17MP0009697_abnormal_copulation2.30823305
18MP0008007_abnormal_cellular_replicative2.30383606
19MP0008932_abnormal_embryonic_tissue2.26031190
20MP0003121_genomic_imprinting2.17679888
21MP0001661_extended_life_span2.12562912
22MP0003763_abnormal_thymus_physiology2.04025116
23MP0004197_abnormal_fetal_growth/weight/2.01596325
24MP0008877_abnormal_DNA_methylation1.94200204
25MP0005083_abnormal_biliary_tract1.92037144
26MP0004808_abnormal_hematopoietic_stem1.82696912
27MP0002084_abnormal_developmental_patter1.81331385
28MP0001697_abnormal_embryo_size1.77997296
29MP0002086_abnormal_extraembryonic_tissu1.76474361
30MP0001672_abnormal_embryogenesis/_devel1.75946220
31MP0005380_embryogenesis_phenotype1.75946220
32MP0000537_abnormal_urethra_morphology1.75190447
33MP0002085_abnormal_embryonic_tissue1.70982510
34MP0002080_prenatal_lethality1.60446674
35MP0003890_abnormal_embryonic-extraembry1.58581075
36MP0005645_abnormal_hypothalamus_physiol1.58517780
37MP0003984_embryonic_growth_retardation1.53846777
38MP0000685_abnormal_immune_system1.53327588
39MP0002088_abnormal_embryonic_growth/wei1.52448152
40MP0000490_abnormal_crypts_of1.49146967
41MP0002396_abnormal_hematopoietic_system1.46982275
42MP0003656_abnormal_erythrocyte_physiolo1.46127337
43MP0003937_abnormal_limbs/digits/tail_de1.44556064
44MP0002019_abnormal_tumor_incidence1.43812476
45MP0003786_premature_aging1.38526389
46MP0001293_anophthalmia1.36294490
47MP0000703_abnormal_thymus_morphology1.33134531
48MP0000733_abnormal_muscle_development1.23205051
49MP0010030_abnormal_orbit_morphology1.22493210
50MP0000313_abnormal_cell_death1.22423670
51MP0005623_abnormal_meninges_morphology1.21819500
52MP0001915_intracranial_hemorrhage1.21325055
53MP0002092_abnormal_eye_morphology1.20259354
54MP0002697_abnormal_eye_size1.19641890
55MP0002877_abnormal_melanocyte_morpholog1.18642277
56MP0005220_abnormal_exocrine_pancreas1.18482675
57MP0002111_abnormal_tail_morphology1.15706194
58MP0001346_abnormal_lacrimal_gland1.15606721
59MP0002166_altered_tumor_susceptibility1.14884863
60MP0009053_abnormal_anal_canal1.14368747
61MP0002009_preneoplasia1.13437527
62MP0006035_abnormal_mitochondrial_morpho1.13104315
63MP0000358_abnormal_cell_content/1.11884929
64MP0003567_abnormal_fetal_cardiomyocyte1.11735513
65MP0003787_abnormal_imprinting1.11320192
66MP0009703_decreased_birth_body1.07035290
67MP0004147_increased_porphyrin_level1.06516957
68MP0008438_abnormal_cutaneous_collagen1.06442289
69MP0002163_abnormal_gland_morphology1.03352528
70MP0003566_abnormal_cell_adhesion1.03176475
71MP0002722_abnormal_immune_system1.02789403
72MP0003718_maternal_effect0.98064889
73MP0008770_decreased_survivor_rate0.97606080
74MP0010678_abnormal_skin_adnexa0.97570154
75MP0009672_abnormal_birth_weight0.97528063
76MP0002006_tumorigenesis0.97509720
77MP0002398_abnormal_bone_marrow0.97083228
78MP0003941_abnormal_skin_development0.96192897
79MP0003806_abnormal_nucleotide_metabolis0.94641311
80MP0001727_abnormal_embryo_implantation0.94637068
81MP0002925_abnormal_cardiovascular_devel0.89778313
82MP0000428_abnormal_craniofacial_morphol0.89600240
83MP0005621_abnormal_cell_physiology0.88154687
84MP0005501_abnormal_skin_physiology0.87773713
85MP0005451_abnormal_body_composition0.86591748
86MP0000689_abnormal_spleen_morphology0.86263291
87MP0001286_abnormal_eye_development0.85794531
88MP0003119_abnormal_digestive_system0.84215873
89MP0003861_abnormal_nervous_system0.83933091
90MP0005384_cellular_phenotype0.83837415
91MP0000432_abnormal_head_morphology0.82950419
92MP0004233_abnormal_muscle_weight0.82378891
93MP0000015_abnormal_ear_pigmentation0.81920014
94MP0001849_ear_inflammation0.80788456
95MP0003300_gastrointestinal_ulcer0.77300830
96MP0004185_abnormal_adipocyte_glucose0.77189536
97MP0005023_abnormal_wound_healing0.77107084
98MP0003315_abnormal_perineum_morphology0.76661155
99MP0003935_abnormal_craniofacial_develop0.73145996
100MP0001835_abnormal_antigen_presentation0.73118173
101MP0002160_abnormal_reproductive_system0.72643494
102MP0005310_abnormal_salivary_gland0.71614063
103MP0009278_abnormal_bone_marrow0.71331602
104MP0003091_abnormal_cell_migration0.69447165
105MP0006072_abnormal_retinal_apoptosis0.68503901
106MP0003115_abnormal_respiratory_system0.68439522
107MP0008995_early_reproductive_senescence0.68066272
108MP0001800_abnormal_humoral_immune0.67686787
109MP0001929_abnormal_gametogenesis0.66908939
110MP0002429_abnormal_blood_cell0.65252953
111MP0001191_abnormal_skin_condition0.64870128
112MP0003699_abnormal_female_reproductive0.64236673
113MP0000477_abnormal_intestine_morphology0.63175661
114MP0000266_abnormal_heart_morphology0.63034255
115MP0005397_hematopoietic_system_phenotyp0.62745350
116MP0001545_abnormal_hematopoietic_system0.62745350
117MP0000569_abnormal_digit_pigmentation0.62708241
118MP0003453_abnormal_keratinocyte_physiol0.62081445
119MP0003283_abnormal_digestive_organ0.61100688
120MP0009931_abnormal_skin_appearance0.60585967
121MP0005391_vision/eye_phenotype0.60248341
122MP0000716_abnormal_immune_system0.59221750
123MP0005187_abnormal_penis_morphology0.58609267
124MP0001119_abnormal_female_reproductive0.57683367
125MP0001145_abnormal_male_reproductive0.56992751
126MP0002210_abnormal_sex_determination0.56863510
127MP0001784_abnormal_fluid_regulation0.56709132
128MP0002282_abnormal_trachea_morphology0.56182531
129MP0005671_abnormal_response_to0.55890497
130MP0002075_abnormal_coat/hair_pigmentati0.55030091
131MP0003385_abnormal_body_wall0.54747227
132MP0005647_abnormal_sex_gland0.52266448
133MP0003221_abnormal_cardiomyocyte_apopto0.50718346
134MP0001873_stomach_inflammation0.50274639

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)5.21269335
2IgA deficiency (HP:0002720)4.98580651
3Colitis (HP:0002583)4.07349385
4Hypochromic microcytic anemia (HP:0004840)3.84626367
5Reticulocytopenia (HP:0001896)3.44759532
6Chromsome breakage (HP:0040012)3.33274464
7Cutaneous melanoma (HP:0012056)3.32808612
8Ependymoma (HP:0002888)3.29672265
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.21242062
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.14580370
11Short 4th metacarpal (HP:0010044)3.14580370
12Astrocytoma (HP:0009592)3.11722184
13Abnormality of the astrocytes (HP:0100707)3.11722184
14Abnormality of chromosome stability (HP:0003220)3.10554894
15Medulloblastoma (HP:0002885)3.01354797
16Colon cancer (HP:0003003)3.00321949
17Microvesicular hepatic steatosis (HP:0001414)2.96145745
18Volvulus (HP:0002580)2.94026919
19Gastrointestinal stroma tumor (HP:0100723)2.93312749
20Rhabdomyosarcoma (HP:0002859)2.84338533
21Nephroblastoma (Wilms tumor) (HP:0002667)2.84173028
22Aplasia/Hypoplasia of the sacrum (HP:0008517)2.77487329
23Poikilocytosis (HP:0004447)2.75507449
24Impulsivity (HP:0100710)2.74995865
25Cellulitis (HP:0100658)2.71667421
26Selective tooth agenesis (HP:0001592)2.69827242
27Abnormality of the labia minora (HP:0012880)2.67401127
28Clubbing of toes (HP:0100760)2.64357804
29Glioma (HP:0009733)2.63351715
30Embryonal renal neoplasm (HP:0011794)2.63326415
31B lymphocytopenia (HP:0010976)2.61083579
32Sandal gap (HP:0001852)2.60996761
33Agnosia (HP:0010524)2.59064097
34Birth length less than 3rd percentile (HP:0003561)2.55214098
35Thyroiditis (HP:0100646)2.52937385
36Deviation of the thumb (HP:0009603)2.46712602
37Biliary tract neoplasm (HP:0100574)2.43749627
38Abnormality of DNA repair (HP:0003254)2.43283093
39Basal cell carcinoma (HP:0002671)2.43183746
40Cafe-au-lait spot (HP:0000957)2.38885260
41Ulnar bowing (HP:0003031)2.38391166
42Increased nuchal translucency (HP:0010880)2.37445002
43Abnormality of reticulocytes (HP:0004312)2.37026685
44Cortical dysplasia (HP:0002539)2.36486252
4511 pairs of ribs (HP:0000878)2.35973863
46Missing ribs (HP:0000921)2.33665406
47Abnormality of pyrimidine metabolism (HP:0004353)2.32439094
48High pitched voice (HP:0001620)2.31943933
49Proximal placement of thumb (HP:0009623)2.31554137
50Duplicated collecting system (HP:0000081)2.30443307
51Neoplasm of the oral cavity (HP:0100649)2.29538627
52Insomnia (HP:0100785)2.26477672
53Abnormality of cells of the erythroid lineage (HP:0012130)2.25252607
54Patellar aplasia (HP:0006443)2.21160218
55Abnormality of the 4th metacarpal (HP:0010012)2.20276056
56Neoplasm of striated muscle (HP:0009728)2.18079748
57Abnormality of B cell number (HP:0010975)2.17836976
58Agammaglobulinemia (HP:0004432)2.15680809
59Lymphoma (HP:0002665)2.15224006
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.13962830
61Duodenal stenosis (HP:0100867)2.13400532
62Small intestinal stenosis (HP:0012848)2.13400532
63Inflammation of the large intestine (HP:0002037)2.12844144
64Abnormality of cochlea (HP:0000375)2.12706139
65Squamous cell carcinoma (HP:0002860)2.12452891
66Hypopigmentation of the fundus (HP:0007894)2.12174896
67Gastrointestinal carcinoma (HP:0002672)2.11692332
68Malignant gastrointestinal tract tumors (HP:0006749)2.11692332
69Prominent nose (HP:0000448)2.10110933
70Heterotopia (HP:0002282)2.08374580
71Recurrent sinusitis (HP:0011108)2.08219468
72Absent frontal sinuses (HP:0002688)2.07357649
73Acute lymphatic leukemia (HP:0006721)2.07333960
74Short thumb (HP:0009778)2.07312474
75Abnormality of the heme biosynthetic pathway (HP:0010472)2.06746030
76Orthostatic hypotension (HP:0001278)2.06239943
77Meckel diverticulum (HP:0002245)2.05598476
78Progressive external ophthalmoplegia (HP:0000590)2.04394435
79Ectopic kidney (HP:0000086)2.03674950
80Abnormality of cells of the lymphoid lineage (HP:0012140)2.03509538
81Ureteral duplication (HP:0000073)2.02426829
82Gastrointestinal inflammation (HP:0004386)2.01857584
83Spastic diplegia (HP:0001264)2.01699208
84Abnormality of the renal collecting system (HP:0004742)2.00836989
85Hypergonadotropic hypogonadism (HP:0000815)2.00705752
86Breast hypoplasia (HP:0003187)2.00587398
87Abnormality of the calcaneus (HP:0008364)2.00548403
88Aplasia/Hypoplasia of the patella (HP:0006498)2.00301739
89Acanthocytosis (HP:0001927)2.00218248
90Lymphopenia (HP:0001888)1.98235628
91Myelodysplasia (HP:0002863)1.98154385
92Arteriovenous malformation (HP:0100026)1.98139025
93Ankle contracture (HP:0006466)1.97864175
94Cutis marmorata (HP:0000965)1.97196375
95Absent thumb (HP:0009777)1.95549721
96Embryonal neoplasm (HP:0002898)1.95507872
97Abnormality of the ileum (HP:0001549)1.95410992
98Macrocytic anemia (HP:0001972)1.94726167
99Sloping forehead (HP:0000340)1.93927680
100Atresia of the external auditory canal (HP:0000413)1.92831605
101Neoplasm of the pancreas (HP:0002894)1.91398537
102Leukopenia (HP:0001882)1.90851742
103Abnormality of chromosome segregation (HP:0002916)1.90457864
104Papilloma (HP:0012740)1.90385983
105Verrucae (HP:0200043)1.90385983
106Abnormal number of incisors (HP:0011064)1.89513846
107Absent radius (HP:0003974)1.88722559
108Hyperacusis (HP:0010780)1.88080976
109Dry hair (HP:0011359)1.87849919
110Freckling (HP:0001480)1.87139043
111Subacute progressive viral hepatitis (HP:0006572)1.86982979
112Abnormality of oral frenula (HP:0000190)1.86850761
113Intestinal polyposis (HP:0200008)1.86658834
114Erythema (HP:0010783)1.86399786
115Recurrent viral infections (HP:0004429)1.86171170
116Ankyloglossia (HP:0010296)1.85728151
117Abnormality of the duodenum (HP:0002246)1.85546408
118Deep philtrum (HP:0002002)1.84608430
119Abnormality of the preputium (HP:0100587)1.84559808
120Ovarian neoplasm (HP:0100615)1.84286576
121Combined immunodeficiency (HP:0005387)1.84086873
122Hypochromic anemia (HP:0001931)1.84048448
123Bone marrow hypocellularity (HP:0005528)1.83787883
124Aqueductal stenosis (HP:0002410)1.83765035
125Prostate neoplasm (HP:0100787)1.83463824
126Long eyelashes (HP:0000527)1.83229187
127Asymmetry of the thorax (HP:0001555)1.83156464
128Pelvic girdle muscle weakness (HP:0003749)1.82870336
129Intestinal polyp (HP:0005266)1.82869626
130Pancreatic islet-cell hyperplasia (HP:0004510)1.82304423
131Truncal obesity (HP:0001956)1.81870708
132Aplasia/Hypoplasia of the sternum (HP:0006714)1.81124642
133Abnormality of the fingertips (HP:0001211)1.80860213
134T lymphocytopenia (HP:0005403)1.80444213
135Duplication of thumb phalanx (HP:0009942)1.79036944
136Large earlobe (HP:0009748)1.78927048
137Wrist flexion contracture (HP:0001239)1.78201703
138Abnormal lung lobation (HP:0002101)1.77893302
139Septate vagina (HP:0001153)1.77800368
140Autoimmune hemolytic anemia (HP:0001890)1.77645492
141Hypoplasia of the thymus (HP:0000778)1.76811445
142Reticulocytosis (HP:0001923)1.76426958
143Abnormality of the carotid arteries (HP:0005344)1.76025880
144Entropion (HP:0000621)1.75790579
145Hepatitis (HP:0012115)1.75700273
146Amaurosis fugax (HP:0100576)1.75021858
147Abnormal foot bone ossification (HP:0010675)1.74923873
148Pallor (HP:0000980)1.74429247
149Increased density of long bones (HP:0006392)1.74304092
150Poikiloderma (HP:0001029)1.74263875
151Uterine leiomyosarcoma (HP:0002891)1.73490063
152Leiomyosarcoma (HP:0100243)1.73490063
153Deep palmar crease (HP:0006191)1.73479913
154Progressive muscle weakness (HP:0003323)1.73326851
155Bowel diverticulosis (HP:0005222)1.73062964
156High anterior hairline (HP:0009890)1.73015564
157Skull defect (HP:0001362)1.72887403

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.51175369
2ZAK6.15629013
3VRK13.43671011
4CDC73.33870363
5STK42.71834488
6MAP3K102.56903611
7RPS6KA52.50577483
8EEF2K2.45830498
9SCYL22.03344335
10NEK22.00236363
11CDK91.91250612
12PKN21.78077404
13BUB11.68225932
14SRPK11.65307971
15SMG11.64731543
16PIM11.61478155
17WEE11.60290884
18CHEK21.53394268
19RPS6KB21.52751596
20MAP3K81.51748467
21* AURKB1.40019011
22CDK121.36148247
23EIF2AK11.33221961
24PASK1.27020818
25TTN1.25650577
26TTK1.24910725
27TAF11.21162391
28EPHA21.18831491
29DYRK31.17927319
30PBK1.13622407
31ATR1.11438936
32* DAPK31.04308833
33PKN11.03665617
34NEK11.03265758
35PLK11.02659997
36GRK61.02133713
37ACVR1B0.96819090
38CDK40.92360261
39AURKA0.92340566
40ICK0.90568694
41STK100.88790278
42MELK0.87114001
43PLK30.84073694
44FLT30.81882359
45TGFBR10.81139143
46CHEK10.80308010
47DYRK1B0.79742566
48PRPF4B0.78954905
49CDK60.78223873
50BRAF0.75943128
51FRK0.75179143
52CDK80.74398094
53ATM0.72197703
54CDK20.63934328
55BRSK20.62905462
56FGFR20.62565584
57AKT20.60162236
58STK30.59320912
59LATS10.59134893
60MAPK110.57067571
61LRRK20.56535808
62CAMK1D0.56250332
63NME20.54645289
64EIF2AK30.52789627
65TRIB30.52066184
66KSR10.50999896
67ALK0.50603448
68CDK10.49620300
69BTK0.47544484
70CSNK1D0.44951988
71CDK70.42987546
72NEK90.41446393
73STK160.39422749
74PIM20.39316461
75BRSK10.38019680
76RPS6KB10.37947954
77MTOR0.37717335
78PDGFRA0.37513085
79TSSK60.36947570
80RPS6KA40.35037717
81RAF10.34832828
82PRKDC0.33403014
83BLK0.33184231
84EIF2AK20.32922187
85PRKAA10.32911890
86PAK20.32603327
87IRAK40.32532384
88IRAK30.32040210
89PAK40.30965698
90PAK10.30591068
91PTK60.30255948
92ROCK10.29792701
93MAP2K30.29259424
94PLK40.27504158
95CSNK1G30.26342082
96JAK20.25855745
97MKNK10.25165742
98CSNK1G10.24995643
99CSNK1A1L0.23509124
100TESK20.23225547
101CLK10.22826914
102CAMK40.22701572
103MAPK140.21545277
104ILK0.21498927
105MAP2K70.20531788
106MAP3K40.20445857
107FGFR10.20355492
108BMX0.20299546
109KDR0.19787467
110CSNK2A20.19430511
111AKT10.18902250
112CCNB10.18352911
113SYK0.18192279
114CAMKK20.16806305
115FGR0.16678436
116RPS6KL10.14309115
117RPS6KC10.14309115
118CSF1R0.14152221
119MAPKAPK50.14066532
120FGFR30.13953048
121TRPM70.13701743
122RIPK10.13662232
123CAMK1G0.13219510
124BRD40.13166784
125TESK10.12880890
126NLK0.12014726
127PRKCQ0.11413375
128BCKDK0.11403262
129MET0.10954966
130PDGFRB0.10925284
131MAP2K40.10773372
132RPS6KA10.08825379
133LYN0.06863814
134CDK150.06752415
135PRKCI0.06630108
136MAP2K20.05854307

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.14842672
2Viral carcinogenesis_Homo sapiens_hsa052033.43689910
3DNA replication_Homo sapiens_hsa030302.99013113
4Mismatch repair_Homo sapiens_hsa034302.64824954
5One carbon pool by folate_Homo sapiens_hsa006702.24186485
6Cell cycle_Homo sapiens_hsa041102.16565496
7* Systemic lupus erythematosus_Homo sapiens_hsa0532210.7430499
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.94649322
9Non-homologous end-joining_Homo sapiens_hsa034501.92961853
10RNA transport_Homo sapiens_hsa030131.83362115
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69420070
12* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.65626317
13Nucleotide excision repair_Homo sapiens_hsa034201.61541318
14Base excision repair_Homo sapiens_hsa034101.54617771
15Spliceosome_Homo sapiens_hsa030401.54232458
16Ribosome_Homo sapiens_hsa030101.51066343
17Fanconi anemia pathway_Homo sapiens_hsa034601.50276444
18Homologous recombination_Homo sapiens_hsa034401.36890689
19p53 signaling pathway_Homo sapiens_hsa041151.25010431
20mRNA surveillance pathway_Homo sapiens_hsa030151.22231784
21MicroRNAs in cancer_Homo sapiens_hsa052061.13020114
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98831636
23Small cell lung cancer_Homo sapiens_hsa052220.88295382
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84863604
25Chronic myeloid leukemia_Homo sapiens_hsa052200.81903482
26Sulfur relay system_Homo sapiens_hsa041220.79272531
27Pyrimidine metabolism_Homo sapiens_hsa002400.79009520
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77162809
29RNA degradation_Homo sapiens_hsa030180.75896169
30Selenocompound metabolism_Homo sapiens_hsa004500.74643920
31HTLV-I infection_Homo sapiens_hsa051660.73566150
32Oocyte meiosis_Homo sapiens_hsa041140.72178405
33Non-small cell lung cancer_Homo sapiens_hsa052230.70864296
34Bladder cancer_Homo sapiens_hsa052190.67215867
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66865944
36mTOR signaling pathway_Homo sapiens_hsa041500.64245633
37Intestinal immune network for IgA production_Homo sapiens_hsa046720.63500898
38RNA polymerase_Homo sapiens_hsa030200.60456628
39Colorectal cancer_Homo sapiens_hsa052100.59813389
40Epstein-Barr virus infection_Homo sapiens_hsa051690.57972273
41Apoptosis_Homo sapiens_hsa042100.51235054
42Central carbon metabolism in cancer_Homo sapiens_hsa052300.50833649
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49403399
44Herpes simplex infection_Homo sapiens_hsa051680.49057775
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47802145
46Glioma_Homo sapiens_hsa052140.47248990
47Pancreatic cancer_Homo sapiens_hsa052120.46769469
48TGF-beta signaling pathway_Homo sapiens_hsa043500.46618348
49Hippo signaling pathway_Homo sapiens_hsa043900.44556223
50FoxO signaling pathway_Homo sapiens_hsa040680.43163231
51Hepatitis B_Homo sapiens_hsa051610.43154645
52Asthma_Homo sapiens_hsa053100.42903827
53Antigen processing and presentation_Homo sapiens_hsa046120.42321951
54Proteoglycans in cancer_Homo sapiens_hsa052050.42157570
55Carbon metabolism_Homo sapiens_hsa012000.41457280
56Lysine degradation_Homo sapiens_hsa003100.41232757
57Thyroid cancer_Homo sapiens_hsa052160.40677115
58Prostate cancer_Homo sapiens_hsa052150.39951072
59B cell receptor signaling pathway_Homo sapiens_hsa046620.39809220
60Fructose and mannose metabolism_Homo sapiens_hsa000510.39446420
61Biosynthesis of amino acids_Homo sapiens_hsa012300.39436098
62Allograft rejection_Homo sapiens_hsa053300.39377194
63Endometrial cancer_Homo sapiens_hsa052130.38806257
64Basal cell carcinoma_Homo sapiens_hsa052170.38270229
65Adherens junction_Homo sapiens_hsa045200.37300462
66Autoimmune thyroid disease_Homo sapiens_hsa053200.36979282
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36254377
68Melanoma_Homo sapiens_hsa052180.35209420
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32604704
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32565644
71Basal transcription factors_Homo sapiens_hsa030220.32503917
72N-Glycan biosynthesis_Homo sapiens_hsa005100.31030114
73Viral myocarditis_Homo sapiens_hsa054160.29616891
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29504302
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29303315
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.28457652
77Purine metabolism_Homo sapiens_hsa002300.27724062
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27621441
79HIF-1 signaling pathway_Homo sapiens_hsa040660.27361457
80Focal adhesion_Homo sapiens_hsa045100.27114172
81Tight junction_Homo sapiens_hsa045300.27091765
82Pathways in cancer_Homo sapiens_hsa052000.26419028
83Legionellosis_Homo sapiens_hsa051340.26158989
84Galactose metabolism_Homo sapiens_hsa000520.25478917
85Notch signaling pathway_Homo sapiens_hsa043300.23251229
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.22179944
87Graft-versus-host disease_Homo sapiens_hsa053320.21964541
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21892513
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21878543
90Measles_Homo sapiens_hsa051620.21597650
91AMPK signaling pathway_Homo sapiens_hsa041520.20322509
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20166128
93Proteasome_Homo sapiens_hsa030500.19446606
94Primary immunodeficiency_Homo sapiens_hsa053400.19082344
95Renin-angiotensin system_Homo sapiens_hsa046140.19054840
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18095204
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.17943369
98Pentose phosphate pathway_Homo sapiens_hsa000300.17324797
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16601802
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.16072787
101Vitamin B6 metabolism_Homo sapiens_hsa007500.15962021
102Pyruvate metabolism_Homo sapiens_hsa006200.15398873
103Arginine biosynthesis_Homo sapiens_hsa002200.15083607
104Platelet activation_Homo sapiens_hsa046110.14984632
105Inositol phosphate metabolism_Homo sapiens_hsa005620.13898993
106Type I diabetes mellitus_Homo sapiens_hsa049400.13672604
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13558969
108Influenza A_Homo sapiens_hsa051640.12562997
109ECM-receptor interaction_Homo sapiens_hsa045120.12004332
110Hedgehog signaling pathway_Homo sapiens_hsa043400.11830164
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.11805779
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.11757921
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.11699074
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.11334115
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11203199
116Acute myeloid leukemia_Homo sapiens_hsa052210.11114990
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.10974032
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.10677205
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.10387998
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10260589
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.09882929
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.08477938
123Leishmaniasis_Homo sapiens_hsa051400.08251317
124Wnt signaling pathway_Homo sapiens_hsa043100.08029809
125ErbB signaling pathway_Homo sapiens_hsa040120.07656879
126Hematopoietic cell lineage_Homo sapiens_hsa046400.05721721
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.05464412

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