HIST1H3C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin assembly (GO:0031497)7.40036940
2nucleosome assembly (GO:0006334)7.22574899
3regulation of histone H3-K9 methylation (GO:0051570)7.05495171
4nucleosome organization (GO:0034728)6.27024730
5antibacterial humoral response (GO:0019731)6.12658613
6protein-DNA complex assembly (GO:0065004)6.09631151
7mitotic chromosome condensation (GO:0007076)6.01285219
8DNA unwinding involved in DNA replication (GO:0006268)5.99150733
9chromatin assembly or disassembly (GO:0006333)5.80388667
10innate immune response in mucosa (GO:0002227)5.74379639
11antimicrobial humoral response (GO:0019730)5.73550313
12protein-DNA complex subunit organization (GO:0071824)5.47250942
13protein localization to kinetochore (GO:0034501)5.45507609
14nuclear pore complex assembly (GO:0051292)5.39928888
15nuclear pore organization (GO:0006999)5.37328503
16regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.19090396
17sister chromatid segregation (GO:0000819)4.87246828
18regulation of gene silencing (GO:0060968)4.84912315
19protein localization to chromosome, centromeric region (GO:0071459)4.68270081
20folic acid-containing compound biosynthetic process (GO:0009396)4.65162880
21mucosal immune response (GO:0002385)4.38634848
22negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.37095957
23mitotic sister chromatid segregation (GO:0000070)4.34494145
24chromatin remodeling at centromere (GO:0031055)4.30557072
25CENP-A containing nucleosome assembly (GO:0034080)4.30274612
26DNA replication initiation (GO:0006270)4.26240507
27negative regulation of histone methylation (GO:0031061)4.25700715
28regulation of posttranscriptional gene silencing (GO:0060147)4.25585340
29regulation of gene silencing by miRNA (GO:0060964)4.25585340
30regulation of gene silencing by RNA (GO:0060966)4.25585340
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.21099638
32organ or tissue specific immune response (GO:0002251)4.14464157
33B cell receptor signaling pathway (GO:0050853)4.07547651
34DNA duplex unwinding (GO:0032508)4.07361541
35DNA geometric change (GO:0032392)4.06716171
36pore complex assembly (GO:0046931)4.04811547
37DNA strand elongation involved in DNA replication (GO:0006271)4.03760150
38IMP biosynthetic process (GO:0006188)3.99950145
39mitotic nuclear envelope disassembly (GO:0007077)3.99450435
40chromosome condensation (GO:0030261)3.95198557
41DNA replication-independent nucleosome organization (GO:0034724)3.89963992
42DNA replication-independent nucleosome assembly (GO:0006336)3.89963992
43regulation of translational fidelity (GO:0006450)3.86478568
44DNA strand elongation (GO:0022616)3.81580221
45positive regulation of chromosome segregation (GO:0051984)3.81577218
46defense response to Gram-positive bacterium (GO:0050830)3.80171623
47nuclear envelope disassembly (GO:0051081)3.78847464
48membrane disassembly (GO:0030397)3.78847464
49protein K6-linked ubiquitination (GO:0085020)3.72954439
50telomere maintenance via semi-conservative replication (GO:0032201)3.72190775
51mitotic recombination (GO:0006312)3.64755938
52dosage compensation (GO:0007549)3.59739505
53immunoglobulin mediated immune response (GO:0016064)3.54157711
54histone exchange (GO:0043486)3.52500662
55IMP metabolic process (GO:0046040)3.51534101
56pre-miRNA processing (GO:0031054)3.49291072
57positive regulation of mitotic sister chromatid separation (GO:1901970)3.47409068
58positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.47409068
59positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.47409068
60histone lysine demethylation (GO:0070076)3.46085710
61translesion synthesis (GO:0019985)3.42902371
62DNA conformation change (GO:0071103)3.41218810
63B cell proliferation (GO:0042100)3.39307164
64viral mRNA export from host cell nucleus (GO:0046784)3.39249066
65regulation of sister chromatid cohesion (GO:0007063)3.36494193
66DNA topological change (GO:0006265)3.36160548
67DNA packaging (GO:0006323)3.35576564
68histone demethylation (GO:0016577)3.35545286
69mitotic sister chromatid cohesion (GO:0007064)3.35521599
70telomere maintenance via recombination (GO:0000722)3.31229582
71kinetochore organization (GO:0051383)3.29951316
72meiotic chromosome segregation (GO:0045132)3.25454115
73T cell lineage commitment (GO:0002360)3.24961733
74ATP-dependent chromatin remodeling (GO:0043044)3.24349672
75positive regulation of histone methylation (GO:0031062)3.22798114
76regulation of centrosome cycle (GO:0046605)3.21538979
77B cell mediated immunity (GO:0019724)3.21124330
78nucleotide-excision repair, DNA gap filling (GO:0006297)3.20817174
79telomere maintenance (GO:0000723)3.20585680
80T-helper 1 type immune response (GO:0042088)3.18151825
81telomere organization (GO:0032200)3.17730877
82regulation of centriole replication (GO:0046599)3.17512489
83nucleobase biosynthetic process (GO:0046112)3.16838843
84protein localization to chromosome (GO:0034502)3.12135008
85attachment of spindle microtubules to kinetochore (GO:0008608)3.11359237
86positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.09764211
87postreplication repair (GO:0006301)3.07325265
88mature B cell differentiation involved in immune response (GO:0002313)3.06310947
89regulation of chromosome segregation (GO:0051983)3.06027215
90DNA synthesis involved in DNA repair (GO:0000731)3.05146185
91negative regulation of B cell apoptotic process (GO:0002903)3.04192577
92determination of adult lifespan (GO:0008340)3.03202143
93regulation of DNA endoreduplication (GO:0032875)3.02570741
94protein dealkylation (GO:0008214)3.01469156
95protein demethylation (GO:0006482)3.01469156
96regulation of helicase activity (GO:0051095)3.01074219
97regulation of translational termination (GO:0006449)3.00670052
98mitotic metaphase plate congression (GO:0007080)3.00359200
99microtubule depolymerization (GO:0007019)2.99061368
100regulation of B cell receptor signaling pathway (GO:0050855)2.96426329
101regulation of spindle organization (GO:0090224)2.96308135
102V(D)J recombination (GO:0033151)2.96173137
103viral transcription (GO:0019083)2.95667533
104telomere maintenance via telomere lengthening (GO:0010833)2.95272486
105regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.94285583
106nuclear envelope organization (GO:0006998)2.91537872
107regulation of megakaryocyte differentiation (GO:0045652)2.90647816
108metaphase plate congression (GO:0051310)2.90216717
109regulation of centrosome duplication (GO:0010824)2.89774395
110regulation of histone methylation (GO:0031060)2.89278374
111translational termination (GO:0006415)2.89261985
112DNA ligation (GO:0006266)2.85914645
113T cell migration (GO:0072678)2.83638762
114deoxyribonucleotide biosynthetic process (GO:0009263)2.83485403
115B cell homeostasis (GO:0001782)2.83045611
116protoporphyrinogen IX biosynthetic process (GO:0006782)2.82753320
117protoporphyrinogen IX metabolic process (GO:0046501)2.81274275
118positive regulation of macrophage cytokine production (GO:0060907)2.79548078
119regulation of protein heterodimerization activity (GO:0043497)2.78763525
120antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.76834143
121replicative senescence (GO:0090399)2.76217089
122somatic hypermutation of immunoglobulin genes (GO:0016446)2.76134823
123somatic diversification of immune receptors via somatic mutation (GO:0002566)2.76134823
124non-recombinational repair (GO:0000726)2.72463721
125double-strand break repair via nonhomologous end joining (GO:0006303)2.72463721
126antigen processing and presentation of endogenous antigen (GO:0019883)2.71307315
127negative regulation of DNA repair (GO:0045738)2.70126984
128tongue development (GO:0043586)2.68319028
129somatic cell DNA recombination (GO:0016444)2.66103728
130somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.66103728
131chromosome segregation (GO:0007059)2.65542440
132establishment of mitotic spindle localization (GO:0040001)2.64444419
133maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.64296008
134peptidyl-lysine dimethylation (GO:0018027)2.63966297
135DNA replication-dependent nucleosome organization (GO:0034723)10.8626679
136DNA replication-dependent nucleosome assembly (GO:0006335)10.8626679

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.28247210
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.38577275
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.27804956
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.91551762
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.18847115
6* SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.09502523
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.38518275
8* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28649102
9* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.19887999
10* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.03598859
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse16.3671203
12E2F1_21310950_ChIP-Seq_MCF-7_Human1.99343035
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92321781
14MYC_18555785_ChIP-Seq_MESCs_Mouse1.87522155
15* SOX2_16153702_ChIP-ChIP_HESCs_Human1.85554989
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82029972
17* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.74247967
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.66158595
19ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65637126
20IRF1_19129219_ChIP-ChIP_H3396_Human1.57091035
21* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.54088801
22SOX2_18555785_ChIP-Seq_MESCs_Mouse1.53000804
23MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50389212
24* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47345013
25KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.46406507
26ESR1_15608294_ChIP-ChIP_MCF-7_Human1.46318076
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.45176783
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43851797
29* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36547849
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31851067
31* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31076324
32KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27558625
33MYC_22102868_ChIP-Seq_BL_Human1.26963751
34AR_21909140_ChIP-Seq_LNCAP_Human1.26042208
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25306595
36* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25204939
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24524602
38* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24204090
39* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.23642831
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22350457
41* VDR_23849224_ChIP-Seq_CD4+_Human1.22103652
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.21574399
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21014648
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20143398
45TCF3_18692474_ChIP-Seq_MESCs_Mouse1.14325686
46* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.13248705
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13080269
48HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12298526
49NANOG_16153702_ChIP-ChIP_HESCs_Human1.05985691
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04420286
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03694303
52ELK1_19687146_ChIP-ChIP_HELA_Human1.02077968
53* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00484015
54TP63_17297297_ChIP-ChIP_HaCaT_Human0.96358224
55* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95753488
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91804213
57ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90858903
58FOXP3_21729870_ChIP-Seq_TREG_Human0.90436570
59VDR_21846776_ChIP-Seq_THP-1_Human0.89538349
60SALL1_21062744_ChIP-ChIP_HESCs_Human0.89336309
61* MAF_26560356_Chip-Seq_TH1_Human0.88775212
62* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88698484
63XRN2_22483619_ChIP-Seq_HELA_Human0.86867627
64SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85889012
65* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.85776452
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.85525746
67PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83862829
68THAP11_20581084_ChIP-Seq_MESCs_Mouse0.83165552
69MYCN_18555785_ChIP-Seq_MESCs_Mouse0.82976397
70ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.82212993
71* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.81840530
72* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80298791
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79919760
74ELF1_17652178_ChIP-ChIP_JURKAT_Human0.78986870
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.78697442
76MYB_26560356_Chip-Seq_TH1_Human0.77398450
77* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76781554
78NOTCH1_21737748_ChIP-Seq_TLL_Human0.76085217
79KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.74372465
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.74011381
81* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.72745453
82ZFX_18555785_ChIP-Seq_MESCs_Mouse0.72507938
83CIITA_25753668_ChIP-Seq_RAJI_Human0.72050407
84RBPJ_22232070_ChIP-Seq_NCS_Mouse0.70767678
85NANOG_21062744_ChIP-ChIP_HESCs_Human0.70540468
86CREB1_15753290_ChIP-ChIP_HEK293T_Human0.70424727
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.69024548
88* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.68190472
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.67869089
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.67003273
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.66585975
92DCP1A_22483619_ChIP-Seq_HELA_Human0.66405436
93PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.66179676
94IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.65313351
95EST1_17652178_ChIP-ChIP_JURKAT_Human0.64364174
96GATA2_22383799_ChIP-Seq_G1ME_Mouse0.63682577
97KDM5A_27292631_Chip-Seq_BREAST_Human0.63672399
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.63407937
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.63178097
100MYB_26560356_Chip-Seq_TH2_Human0.62459662
101POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.61929240
102MYC_18940864_ChIP-ChIP_HL60_Human0.61528905
103ETS1_20019798_ChIP-Seq_JURKAT_Human0.61524340
104HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.60955700
105UTX_26944678_Chip-Seq_JUKART_Human0.59452451
106SALL4_22934838_ChIP-ChIP_CD34+_Human0.58542460
107* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.58524262
108MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.57650577
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.57642243
110GATA1_22025678_ChIP-Seq_K562_Human0.57408390
111* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.57246851
112* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.56954164
113JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.56106447
114TTF2_22483619_ChIP-Seq_HELA_Human0.56094551
115VDR_24763502_ChIP-Seq_THP-1_Human0.55749899
116KLF4_18555785_ChIP-Seq_MESCs_Mouse0.55407414
117TCF7_22412390_ChIP-Seq_EML_Mouse0.54585582
118SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.54302259
119SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.53775872
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.49607614

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.23033328
2MP0003111_abnormal_nucleus_morphology4.45260298
3MP0010307_abnormal_tumor_latency3.85429425
4MP0003077_abnormal_cell_cycle3.78280026
5MP0003693_abnormal_embryo_hatching3.52810766
6MP0005645_abnormal_hypothalamus_physiol3.36976501
7MP0004957_abnormal_blastocyst_morpholog3.36147277
8MP0010352_gastrointestinal_tract_polyps3.17259441
9MP0008057_abnormal_DNA_replication3.16765777
10MP0003763_abnormal_thymus_physiology2.80151056
11MP0010234_abnormal_vibrissa_follicle2.70524908
12MP0001835_abnormal_antigen_presentation2.68091836
13MP0005076_abnormal_cell_differentiation2.58262765
14MP0005671_abnormal_response_to2.53039490
15MP0006054_spinal_hemorrhage2.51209760
16MP0008058_abnormal_DNA_repair2.44306257
17MP0000350_abnormal_cell_proliferation2.39647520
18MP0003705_abnormal_hypodermis_morpholog2.38713390
19MP0001730_embryonic_growth_arrest2.33090926
20MP0008007_abnormal_cellular_replicative2.22126689
21MP0001790_abnormal_immune_system2.21987735
22MP0005387_immune_system_phenotype2.21987735
23MP0002138_abnormal_hepatobiliary_system2.13895673
24MP0008932_abnormal_embryonic_tissue2.09011677
25MP0003123_paternal_imprinting2.07071895
26MP0009697_abnormal_copulation1.89457093
27MP0003121_genomic_imprinting1.89241441
28MP0004197_abnormal_fetal_growth/weight/1.87813893
29MP0004808_abnormal_hematopoietic_stem1.87607409
30MP0000372_irregular_coat_pigmentation1.87372368
31MP0008877_abnormal_DNA_methylation1.81924575
32MP0002396_abnormal_hematopoietic_system1.80787325
33MP0002086_abnormal_extraembryonic_tissu1.75640944
34MP0001697_abnormal_embryo_size1.73087441
35MP0000490_abnormal_crypts_of1.72676629
36MP0005380_embryogenesis_phenotype1.72087600
37MP0001672_abnormal_embryogenesis/_devel1.72087600
38MP0002084_abnormal_developmental_patter1.71175922
39MP0005000_abnormal_immune_tolerance1.71122651
40MP0002085_abnormal_embryonic_tissue1.69100119
41MP0003656_abnormal_erythrocyte_physiolo1.64854912
42MP0002080_prenatal_lethality1.63079735
43MP0002019_abnormal_tumor_incidence1.58810456
44MP0000703_abnormal_thymus_morphology1.56237250
45MP0003984_embryonic_growth_retardation1.50168153
46MP0002088_abnormal_embryonic_growth/wei1.48128402
47MP0003183_abnormal_peptide_metabolism1.42055604
48MP0002723_abnormal_immune_serum1.38704958
49MP0003950_abnormal_plasma_membrane1.38700737
50MP0003806_abnormal_nucleotide_metabolis1.37935778
51MP0000313_abnormal_cell_death1.33505635
52MP0002398_abnormal_bone_marrow1.31572325
53MP0005171_absent_coat_pigmentation1.30834413
54MP0002722_abnormal_immune_system1.30776663
55MP0000015_abnormal_ear_pigmentation1.27938793
56MP0004381_abnormal_hair_follicle1.26703019
57MP0000537_abnormal_urethra_morphology1.26565520
58MP0002166_altered_tumor_susceptibility1.25930303
59MP0005623_abnormal_meninges_morphology1.25122568
60MP0004147_increased_porphyrin_level1.24737918
61MP0003787_abnormal_imprinting1.24064718
62MP0003786_premature_aging1.23896902
63MP0000689_abnormal_spleen_morphology1.23762203
64MP0001915_intracranial_hemorrhage1.22314981
65MP0000733_abnormal_muscle_development1.20524297
66MP0001661_extended_life_span1.19659459
67MP0009046_muscle_twitch1.19474054
68MP0002877_abnormal_melanocyte_morpholog1.15991756
69MP0001727_abnormal_embryo_implantation1.15138082
70MP0001849_ear_inflammation1.14749766
71MP0000569_abnormal_digit_pigmentation1.10591843
72MP0005310_abnormal_salivary_gland1.10308063
73MP0002009_preneoplasia1.07031114
74MP0002006_tumorigenesis1.04603904
75MP0001800_abnormal_humoral_immune1.03156694
76MP0001293_anophthalmia1.02758598
77MP0003566_abnormal_cell_adhesion1.00494550
78MP0002928_abnormal_bile_duct1.00096530
79MP0003937_abnormal_limbs/digits/tail_de0.98111973
80MP0003567_abnormal_fetal_cardiomyocyte0.97316328
81MP0008770_decreased_survivor_rate0.97272758
82MP0005220_abnormal_exocrine_pancreas0.96393019
83MP0009278_abnormal_bone_marrow0.94999646
84MP0005025_abnormal_response_to0.94607515
85MP0002111_abnormal_tail_morphology0.93983352
86MP0003252_abnormal_bile_duct0.93590661
87MP0002429_abnormal_blood_cell0.92964954
88MP0005621_abnormal_cell_physiology0.90914552
89MP0003300_gastrointestinal_ulcer0.90731981
90MP0010155_abnormal_intestine_physiology0.90427519
91MP0002697_abnormal_eye_size0.90328240
92MP0003303_peritoneal_inflammation0.89888540
93MP0000371_diluted_coat_color0.89422407
94MP0005023_abnormal_wound_healing0.89404400
95MP0005075_abnormal_melanosome_morpholog0.89140492
96MP0002075_abnormal_coat/hair_pigmentati0.88633614
97MP0002092_abnormal_eye_morphology0.88541150
98MP0005384_cellular_phenotype0.87494605
99MP0002095_abnormal_skin_pigmentation0.87411309
100MP0003890_abnormal_embryonic-extraembry0.86574896
101MP0009703_decreased_birth_body0.86493985
102MP0002163_abnormal_gland_morphology0.84755114
103MP0010678_abnormal_skin_adnexa0.84672401
104MP0004185_abnormal_adipocyte_glucose0.83545438
105MP0005501_abnormal_skin_physiology0.83417681
106MP0006035_abnormal_mitochondrial_morpho0.82936653
107MP0004233_abnormal_muscle_weight0.82418861
108MP0004264_abnormal_extraembryonic_tissu0.82152049
109MP0004947_skin_inflammation0.81990901
110MP0008438_abnormal_cutaneous_collagen0.81430065
111MP0005397_hematopoietic_system_phenotyp0.80679011
112MP0001545_abnormal_hematopoietic_system0.80679011
113MP0000716_abnormal_immune_system0.78783410
114MP0001845_abnormal_inflammatory_respons0.77958822
115MP0000685_abnormal_immune_system0.77612263
116MP0002925_abnormal_cardiovascular_devel0.77443844
117MP0009672_abnormal_birth_weight0.77299485
118MP0005451_abnormal_body_composition0.74665553
119MP0002452_abnormal_antigen_presenting0.74610110
120MP0003941_abnormal_skin_development0.71433290
121MP0003861_abnormal_nervous_system0.71385337
122MP0003448_altered_tumor_morphology0.71359065
123MP0001348_abnormal_lacrimal_gland0.71030441
124MP0002139_abnormal_hepatobiliary_system0.69169472
125MP0005083_abnormal_biliary_tract0.68883372
126MP0009333_abnormal_splenocyte_physiolog0.68472627
127MP0003453_abnormal_keratinocyte_physiol0.68268235
128MP0001191_abnormal_skin_condition0.67828480
129MP0002405_respiratory_system_inflammati0.66703243
130MP0000477_abnormal_intestine_morphology0.65322697
131MP0009931_abnormal_skin_appearance0.64234984
132MP0002210_abnormal_sex_determination0.64027711
133MP0001145_abnormal_male_reproductive0.63649013
134MP0004134_abnormal_chest_morphology0.62377975
135MP0002420_abnormal_adaptive_immunity0.62149449
136MP0001929_abnormal_gametogenesis0.60847138
137MP0010030_abnormal_orbit_morphology0.60802764
138MP0003091_abnormal_cell_migration0.60179231
139MP0003119_abnormal_digestive_system0.59932757
140MP0001819_abnormal_immune_cell0.59867294
141MP0009785_altered_susceptibility_to0.59822302
142MP0000358_abnormal_cell_content/0.59773397
143MP0000432_abnormal_head_morphology0.59167996
144MP0003718_maternal_effect0.58337377

Predicted human phenotypes

RankGene SetZ-score
1IgA deficiency (HP:0002720)6.64071046
2Gastrointestinal stroma tumor (HP:0100723)6.15779418
3Agammaglobulinemia (HP:0004432)5.36574429
4Recurrent sinusitis (HP:0011108)4.85219079
5Colitis (HP:0002583)4.72211502
6Recurrent bronchitis (HP:0002837)4.36164755
7Dry hair (HP:0011359)3.94221837
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.86263402
9Chromsome breakage (HP:0040012)3.84881882
10Lymphopenia (HP:0001888)3.75663943
11Ependymoma (HP:0002888)3.72193045
12Abnormality of cells of the lymphoid lineage (HP:0012140)3.70963204
13Reticulocytopenia (HP:0001896)3.63905079
14Cutaneous melanoma (HP:0012056)3.45416455
15Onycholysis (HP:0001806)3.45214431
16Meningitis (HP:0001287)3.31375915
17Impulsivity (HP:0100710)3.29428734
18Thyroiditis (HP:0100646)3.19020576
19Chronic diarrhea (HP:0002028)3.16186377
20Ridged nail (HP:0001807)3.13764113
21Poikilocytosis (HP:0004447)3.13704188
22Abnormality of chromosome stability (HP:0003220)3.11310367
23Astrocytoma (HP:0009592)3.08654441
24Abnormality of the astrocytes (HP:0100707)3.08654441
25Cortical dysplasia (HP:0002539)3.03947554
26Verrucae (HP:0200043)3.00016924
27Papilloma (HP:0012740)3.00016924
28Hypochromic microcytic anemia (HP:0004840)2.98117544
29Emphysema (HP:0002097)2.98040974
30Medulloblastoma (HP:0002885)2.92354871
31Abnormality of T cell physiology (HP:0011840)2.91908536
32Agnosia (HP:0010524)2.90434869
33Inflammation of the large intestine (HP:0002037)2.87514572
34Abnormality of the labia minora (HP:0012880)2.87470933
35Osteomyelitis (HP:0002754)2.86124178
36Recurrent pneumonia (HP:0006532)2.84030095
37Rhabdomyosarcoma (HP:0002859)2.83197079
38Panhypogammaglobulinemia (HP:0003139)2.82136475
39Recurrent lower respiratory tract infections (HP:0002783)2.80092907
40Basal cell carcinoma (HP:0002671)2.79320743
41IgG deficiency (HP:0004315)2.77756241
42Erythema (HP:0010783)2.73273694
43Birth length less than 3rd percentile (HP:0003561)2.72321236
44Gastrointestinal inflammation (HP:0004386)2.72198841
45Leukopenia (HP:0001882)2.67412666
46Cafe-au-lait spot (HP:0000957)2.62853410
47Vasculitis (HP:0002633)2.60506070
48Abnormality of reticulocytes (HP:0004312)2.60313198
49Abnormality of the fingertips (HP:0001211)2.58974985
50Oral leukoplakia (HP:0002745)2.57760473
51Selective tooth agenesis (HP:0001592)2.54639216
52Cholecystitis (HP:0001082)2.52396826
53Abnormal gallbladder physiology (HP:0012438)2.52396826
54Abnormal delayed hypersensitivity skin test (HP:0002963)2.52048606
55Volvulus (HP:0002580)2.50255219
56High pitched voice (HP:0001620)2.50118666
57Short 4th metacarpal (HP:0010044)2.49950083
58Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.49950083
59Neoplasm of the oral cavity (HP:0100649)2.49339478
60Abnormality of the prostate (HP:0008775)2.47711189
61Abnormality of B cell number (HP:0010975)2.47106573
62B lymphocytopenia (HP:0010976)2.47106573
63Prostate neoplasm (HP:0100787)2.44484327
64Glioma (HP:0009733)2.43386959
65Hypopigmentation of the fundus (HP:0007894)2.41228171
66Sandal gap (HP:0001852)2.41148411
67Combined immunodeficiency (HP:0005387)2.40668560
68Mediastinal lymphadenopathy (HP:0100721)2.38788971
69Colon cancer (HP:0003003)2.38257956
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.35621191
71Autoimmune hemolytic anemia (HP:0001890)2.35454245
72Skin rash (HP:0000988)2.34657429
73Prominent nose (HP:0000448)2.34299655
74Urticaria (HP:0001025)2.34063943
75Ulnar bowing (HP:0003031)2.32851021
76Hypoplasia of the thymus (HP:0000778)2.32520445
77Biliary tract neoplasm (HP:0100574)2.28842267
78Small epiphyses (HP:0010585)2.27761524
79Orthostatic hypotension (HP:0001278)2.27001854
80Neoplasm of striated muscle (HP:0009728)2.26839648
81Cellulitis (HP:0100658)2.26306557
82Meckel diverticulum (HP:0002245)2.22146985
83Hepatitis (HP:0012115)2.21927410
84Severe combined immunodeficiency (HP:0004430)2.19332771
85Malignant gastrointestinal tract tumors (HP:0006749)2.19246518
86Gastrointestinal carcinoma (HP:0002672)2.19246518
87Duodenal stenosis (HP:0100867)2.18133817
88Small intestinal stenosis (HP:0012848)2.18133817
89Viral hepatitis (HP:0006562)2.17405918
90Acanthocytosis (HP:0001927)2.17072232
91Abnormality of the ileum (HP:0001549)2.14640271
92Patellar aplasia (HP:0006443)2.13815523
93Restrictive lung disease (HP:0002091)2.13748354
94Ectopic kidney (HP:0000086)2.12859034
95Increased nuchal translucency (HP:0010880)2.12236825
96Abnormality of the preputium (HP:0100587)2.11910571
97Freckling (HP:0001480)2.11893359
98Myelodysplasia (HP:0002863)2.11823045
99Entropion (HP:0000621)2.11702109
100Clubbing of toes (HP:0100760)2.11442450
101Hypoplasia of the capital femoral epiphysis (HP:0003090)2.11442061
102Absent thumb (HP:0009777)2.10570350
103Bronchitis (HP:0012387)2.10561738
104T lymphocytopenia (HP:0005403)2.09634085
105Abnormality of cells of the erythroid lineage (HP:0012130)2.08601319
106Duplicated collecting system (HP:0000081)2.07897718
107Squamous cell carcinoma (HP:0002860)2.07320418
108Sloping forehead (HP:0000340)2.05506127
109Deviation of the thumb (HP:0009603)2.04882058
110Cutis marmorata (HP:0000965)2.02237226
111Reticulocytosis (HP:0001923)2.02042765
112Insomnia (HP:0100785)2.01996329
113Proximal placement of thumb (HP:0009623)2.01827387
114Heterotopia (HP:0002282)2.01715607
115Abnormal number of incisors (HP:0011064)2.00643922
116Macrocytic anemia (HP:0001972)2.00407107
117Recurrent otitis media (HP:0000403)1.98981427
118Subacute progressive viral hepatitis (HP:0006572)1.98447065
119Large earlobe (HP:0009748)1.97151620
120Sparse scalp hair (HP:0002209)1.97027455
121Spastic diplegia (HP:0001264)1.95807970
122Abnormality of the carotid arteries (HP:0005344)1.94607181
123Lymphoma (HP:0002665)1.94442681
124Amaurosis fugax (HP:0100576)1.94415921
125Absent radius (HP:0003974)1.93012587
126Sepsis (HP:0100806)1.92245831
127Aplasia/Hypoplasia of the patella (HP:0006498)1.91645151
128Pallor (HP:0000980)1.90174437
129Missing ribs (HP:0000921)1.90070660
13011 pairs of ribs (HP:0000878)1.89593934
131Adenoma sebaceum (HP:0009720)1.88357780
132Angiofibromas (HP:0010615)1.88357780
133Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.87446301
134Neoplasm of the pancreas (HP:0002894)1.86621743
135Recurrent viral infections (HP:0004429)1.86075648
136Skull defect (HP:0001362)1.86068247
137Abnormality of chromosome segregation (HP:0002916)1.85578667
138Abnormality of the duodenum (HP:0002246)1.85309639
139Abnormality of the heme biosynthetic pathway (HP:0010472)1.85188366
140Abnormality of T cell number (HP:0011839)1.84762738
141Cutaneous photosensitivity (HP:0000992)1.84515822
142Abnormality of DNA repair (HP:0003254)1.83133570
143Conical tooth (HP:0000698)1.82219216
144Recurrent bacterial skin infections (HP:0005406)1.82109808
145Abnormality of T cells (HP:0002843)1.81228078
146Ovarian neoplasm (HP:0100615)1.80500282
147Poikiloderma (HP:0001029)1.76514232
148Abnormality of pyrimidine metabolism (HP:0004353)1.76450437
149IgM deficiency (HP:0002850)1.76433852
150Aplasia involving forearm bones (HP:0009822)1.75679176
151Absent forearm bone (HP:0003953)1.75679176
152Hyperacusis (HP:0010780)1.73808571
153Neutropenia (HP:0001875)1.73632639
154Abnormal number of erythroid precursors (HP:0012131)1.73423325
155Eczematoid dermatitis (HP:0000976)1.73152412
156Abnormality of incisor morphology (HP:0011063)1.72555437
157Teleangiectasia of the skin (HP:0100585)1.72007745
158Lower limb hyperreflexia (HP:0002395)1.71219613
159Microvesicular hepatic steatosis (HP:0001414)1.69578567
160Milia (HP:0001056)1.68858750
161Nephroblastoma (Wilms tumor) (HP:0002667)1.65433295
162Xerostomia (HP:0000217)1.64952815
163Rough bone trabeculation (HP:0100670)1.63173304
164Down-sloping shoulders (HP:0200021)1.56717170
165Neoplasm of the heart (HP:0100544)1.56264519

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK6.75465544
2VRK13.84784360
3STK43.10871138
4MAP3K102.69549078
5RPS6KA52.65510570
6CDC72.58707590
7CDK92.02139679
8TLK110.7679902
9SMG11.82046519
10PIM11.82024351
11EEF2K1.76552485
12CDK121.71137460
13NEK21.69653200
14PKN21.60472539
15MAP3K81.59954995
16SCYL21.54345348
17GRK61.48102921
18WEE11.44945318
19AURKB1.42372093
20BUB11.37637013
21PKN11.35971746
22RPS6KB21.33339333
23SRPK11.22914623
24EPHA21.21524674
25CHEK21.20018242
26TAF11.16755949
27DAPK30.98570236
28NEK10.97526339
29AURKA0.91362454
30TTK0.89266803
31BLK0.86344316
32CDK40.85750474
33FLT30.82432690
34ATR0.82101074
35PLK10.79812546
36DYRK30.78208931
37NEK90.78044715
38IRAK40.76340945
39BTK0.72613019
40SYK0.71599225
41PLK40.70120354
42PBK0.69484995
43STK100.69148094
44PRPF4B0.68971989
45BCKDK0.65955760
46CHEK10.63025554
47EIF2AK10.60849406
48AKT20.60762564
49PASK0.59969633
50DYRK1B0.59392149
51PLK30.57349722
52CDK70.52925403
53ATM0.51004343
54CDK20.50760689
55BRAF0.50613837
56CDK60.49778117
57MELK0.49295754
58VRK20.48735717
59ACVR1B0.48695124
60TTN0.47635917
61CDK80.46843368
62BRD40.46718212
63PRKAA10.45087275
64EIF2AK30.44382950
65CAMK1D0.44214231
66LRRK20.42690059
67MAP2K70.41949965
68CSNK1D0.40999551
69TRIB30.40943151
70FGFR20.39478311
71FRK0.39102157
72JAK20.39039593
73CDK10.35718642
74TSSK60.34858114
75KSR10.33201482
76STK30.32605237
77ALK0.31604401
78PAK10.30915330
79MST40.30055717
80MAP3K140.29245154
81MTOR0.29206593
82TBK10.29088542
83NME20.27590688
84PIK3CG0.27349345
85BRSK20.27335655
86MET0.27331937
87MAP3K40.26534358
88PAK40.24734901
89PRKCQ0.24661887
90BMX0.24568393
91ROCK10.24002052
92TESK20.23987069
93MAP4K10.23500199
94IKBKE0.22822355
95MAPKAPK50.22667321
96PIM20.21399109
97PRKDC0.21176498
98RPS6KB10.20946203
99MARK30.20174862
100TRPM70.19174878
101CLK10.18867955
102MAPK140.17408615
103IKBKB0.17231473
104BRSK10.16193445
105BMPR1B0.15466798
106MAPKAPK30.15027729
107FGFR30.14460410
108CSNK2A20.14421607
109AKT10.14414066
110PAK20.13750979
111FGR0.12956222
112TGFBR10.12750332
113CSF1R0.12454991
114EIF2AK20.12187518
115PTK60.11828880
116ARAF0.11060614
117CAMK40.11029504
118ICK0.09877153
119CCNB10.08336489
120PDGFRA0.08304304
121LYN0.07898013
122MAPK10.07771769
123PRKCD0.07723174
124RPS6KA30.07625052
125MAPK110.07394014
126RAF10.07089675
127CDK150.07087136
128KSR20.06893145
129HIPK20.06636383
130RET0.06416989
131CSNK1G30.06072998
132PRKCI0.05676143
133PRKCB0.05202477
134GSK3B0.04859694
135CSNK1A1L0.03883456
136FGFR40.03799272
137MAP3K130.03631268

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.54454216
2Viral carcinogenesis_Homo sapiens_hsa052033.49998234
3DNA replication_Homo sapiens_hsa030302.91407936
4Mismatch repair_Homo sapiens_hsa034302.63528867
5One carbon pool by folate_Homo sapiens_hsa006702.07351784
6* Systemic lupus erythematosus_Homo sapiens_hsa0532211.4931406
7Non-homologous end-joining_Homo sapiens_hsa034501.89652987
8Cell cycle_Homo sapiens_hsa041101.80743046
9* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.68999361
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65865804
11Allograft rejection_Homo sapiens_hsa053301.65668926
12Base excision repair_Homo sapiens_hsa034101.61033599
13RNA transport_Homo sapiens_hsa030131.57355379
14Asthma_Homo sapiens_hsa053101.56029733
15Autoimmune thyroid disease_Homo sapiens_hsa053201.54780196
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54624478
17Nucleotide excision repair_Homo sapiens_hsa034201.49904039
18Homologous recombination_Homo sapiens_hsa034401.39624658
19Fanconi anemia pathway_Homo sapiens_hsa034601.39241689
20Graft-versus-host disease_Homo sapiens_hsa053321.34007922
21Spliceosome_Homo sapiens_hsa030401.31937634
22Ribosome_Homo sapiens_hsa030101.22211223
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22101335
24Type I diabetes mellitus_Homo sapiens_hsa049401.13833104
25p53 signaling pathway_Homo sapiens_hsa041150.99560139
26mRNA surveillance pathway_Homo sapiens_hsa030150.97854968
27MicroRNAs in cancer_Homo sapiens_hsa052060.90351048
28Pyrimidine metabolism_Homo sapiens_hsa002400.76230390
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74443061
30Small cell lung cancer_Homo sapiens_hsa052220.69651735
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68491219
32Leishmaniasis_Homo sapiens_hsa051400.68103089
33Selenocompound metabolism_Homo sapiens_hsa004500.66846250
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66391759
35RNA polymerase_Homo sapiens_hsa030200.63556624
36Chronic myeloid leukemia_Homo sapiens_hsa052200.61598845
37Epstein-Barr virus infection_Homo sapiens_hsa051690.60826950
38Oocyte meiosis_Homo sapiens_hsa041140.60098440
39HTLV-I infection_Homo sapiens_hsa051660.59973230
40Non-small cell lung cancer_Homo sapiens_hsa052230.58025157
41RNA degradation_Homo sapiens_hsa030180.57696649
42B cell receptor signaling pathway_Homo sapiens_hsa046620.56002127
43mTOR signaling pathway_Homo sapiens_hsa041500.54759725
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49836587
45Lysine degradation_Homo sapiens_hsa003100.49320609
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.48561898
47Herpes simplex infection_Homo sapiens_hsa051680.47037207
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45264687
49Fructose and mannose metabolism_Homo sapiens_hsa000510.43877147
50Biosynthesis of amino acids_Homo sapiens_hsa012300.43755162
51Pentose phosphate pathway_Homo sapiens_hsa000300.42430442
52Bladder cancer_Homo sapiens_hsa052190.42181321
53Apoptosis_Homo sapiens_hsa042100.41846820
54Primary immunodeficiency_Homo sapiens_hsa053400.37301544
55Antigen processing and presentation_Homo sapiens_hsa046120.37097738
56Colorectal cancer_Homo sapiens_hsa052100.37032575
57Staphylococcus aureus infection_Homo sapiens_hsa051500.36075795
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.35707605
59Hepatitis B_Homo sapiens_hsa051610.35701477
60Glioma_Homo sapiens_hsa052140.35143924
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34953328
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31667244
63Toxoplasmosis_Homo sapiens_hsa051450.29897718
64FoxO signaling pathway_Homo sapiens_hsa040680.28624599
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.28408426
66Pancreatic cancer_Homo sapiens_hsa052120.27578673
67Renin-angiotensin system_Homo sapiens_hsa046140.25960079
68Measles_Homo sapiens_hsa051620.24880299
69Prostate cancer_Homo sapiens_hsa052150.24705518
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24625672
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24502640
72Sulfur relay system_Homo sapiens_hsa041220.24472052
73Notch signaling pathway_Homo sapiens_hsa043300.23995481
74Melanoma_Homo sapiens_hsa052180.23945495
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22852953
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22808361
77Basal transcription factors_Homo sapiens_hsa030220.22583472
78Purine metabolism_Homo sapiens_hsa002300.22213688
79Hematopoietic cell lineage_Homo sapiens_hsa046400.21855792
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21848426
81HIF-1 signaling pathway_Homo sapiens_hsa040660.21348574
82Proteoglycans in cancer_Homo sapiens_hsa052050.20414804
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20166415
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18621795
85Phenylalanine metabolism_Homo sapiens_hsa003600.17848007
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17616079
87Inositol phosphate metabolism_Homo sapiens_hsa005620.17314714
88TGF-beta signaling pathway_Homo sapiens_hsa043500.16143673
89Endometrial cancer_Homo sapiens_hsa052130.15780123
90Pathways in cancer_Homo sapiens_hsa052000.14957057
91Tuberculosis_Homo sapiens_hsa051520.14838870
92Legionellosis_Homo sapiens_hsa051340.14630347
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.14199563
94Galactose metabolism_Homo sapiens_hsa000520.13868334
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13745159
96Influenza A_Homo sapiens_hsa051640.13727601
97Hippo signaling pathway_Homo sapiens_hsa043900.13438638
98Rheumatoid arthritis_Homo sapiens_hsa053230.12967864
99Carbon metabolism_Homo sapiens_hsa012000.12542542
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.12536532
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.12258010
102Proteasome_Homo sapiens_hsa030500.12246339
103Thyroid cancer_Homo sapiens_hsa052160.11840356
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.11572913
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.11367207
106Viral myocarditis_Homo sapiens_hsa054160.11239694
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.10939261
108Adherens junction_Homo sapiens_hsa045200.10564260
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10500388
110Basal cell carcinoma_Homo sapiens_hsa052170.09615567
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.09526498
112Phagosome_Homo sapiens_hsa041450.09460369
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.08650237
114Toll-like receptor signaling pathway_Homo sapiens_hsa046200.08416653
115AMPK signaling pathway_Homo sapiens_hsa041520.08066643
116Platelet activation_Homo sapiens_hsa046110.07789627
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.07478091
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07177440
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.06903679
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.06419986
121Pyruvate metabolism_Homo sapiens_hsa006200.06389736
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.06070904
123Acute myeloid leukemia_Homo sapiens_hsa052210.06045065
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.05990849
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.05820473
126Osteoclast differentiation_Homo sapiens_hsa043800.05675840
127Focal adhesion_Homo sapiens_hsa045100.05303613
128Nitrogen metabolism_Homo sapiens_hsa009100.05195315
129N-Glycan biosynthesis_Homo sapiens_hsa005100.03469797
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.03010387

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