HIST1H3D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome assembly (GO:0006335)9.55855951
2DNA replication-dependent nucleosome organization (GO:0034723)9.55855951
3chromatin assembly (GO:0031497)7.74252132
4regulation of histone H3-K9 methylation (GO:0051570)7.10074495
5nucleosome assembly (GO:0006334)6.72833215
6nucleosome organization (GO:0034728)5.85303704
7nuclear pore complex assembly (GO:0051292)5.84323122
8nuclear pore organization (GO:0006999)5.83580397
9chromatin assembly or disassembly (GO:0006333)5.81695530
10DNA unwinding involved in DNA replication (GO:0006268)5.71546689
11protein-DNA complex assembly (GO:0065004)5.68979394
12protein localization to kinetochore (GO:0034501)5.23391562
13protein-DNA complex subunit organization (GO:0071824)5.11906546
14regulation of megakaryocyte differentiation (GO:0045652)4.99233922
15antibacterial humoral response (GO:0019731)4.98849625
16mitotic chromosome condensation (GO:0007076)4.91096825
17sister chromatid segregation (GO:0000819)4.71008014
18innate immune response in mucosa (GO:0002227)4.70426725
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.66660265
20regulation of gene silencing (GO:0060968)4.65685748
21antimicrobial humoral response (GO:0019730)4.65507968
22chromatin remodeling at centromere (GO:0031055)4.55758309
23folic acid-containing compound biosynthetic process (GO:0009396)4.53390517
24CENP-A containing nucleosome assembly (GO:0034080)4.52948974
25DNA replication initiation (GO:0006270)4.48043089
26pore complex assembly (GO:0046931)4.46048415
27protein localization to chromosome, centromeric region (GO:0071459)4.42537312
28mitotic sister chromatid segregation (GO:0000070)4.35453925
29regulation of gene silencing by RNA (GO:0060966)4.21943435
30regulation of posttranscriptional gene silencing (GO:0060147)4.21943435
31regulation of gene silencing by miRNA (GO:0060964)4.21943435
32IMP biosynthetic process (GO:0006188)4.16549647
33mitotic nuclear envelope disassembly (GO:0007077)4.14719557
34negative regulation of histone methylation (GO:0031061)4.08998631
35DNA replication-independent nucleosome assembly (GO:0006336)4.08103493
36DNA replication-independent nucleosome organization (GO:0034724)4.08103493
37DNA strand elongation involved in DNA replication (GO:0006271)4.08100309
38regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.03402862
39DNA geometric change (GO:0032392)3.98609497
40DNA duplex unwinding (GO:0032508)3.97376170
41mature B cell differentiation involved in immune response (GO:0002313)3.94976541
42nuclear envelope disassembly (GO:0051081)3.92891908
43membrane disassembly (GO:0030397)3.92891908
44DNA strand elongation (GO:0022616)3.88381779
45protein K6-linked ubiquitination (GO:0085020)3.84715512
46B cell receptor signaling pathway (GO:0050853)3.80260638
47telomere maintenance via semi-conservative replication (GO:0032201)3.79573675
48dosage compensation (GO:0007549)3.77171767
49positive regulation of chromosome segregation (GO:0051984)3.75066813
50negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.72309102
51histone exchange (GO:0043486)3.70373476
52IMP metabolic process (GO:0046040)3.65804761
53kinetochore organization (GO:0051383)3.64610946
54positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.63046951
55mitotic recombination (GO:0006312)3.62021811
56translesion synthesis (GO:0019985)3.61520657
57regulation of translational fidelity (GO:0006450)3.58519807
58mucosal immune response (GO:0002385)3.58280604
59positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.54110879
60positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.54110879
61positive regulation of mitotic sister chromatid separation (GO:1901970)3.54110879
62positive regulation of histone methylation (GO:0031062)3.52905903
63negative regulation of B cell apoptotic process (GO:0002903)3.51071510
64attachment of spindle microtubules to kinetochore (GO:0008608)3.49947356
65mitotic sister chromatid cohesion (GO:0007064)3.49699636
66meiotic chromosome segregation (GO:0045132)3.48864744
67protoporphyrinogen IX metabolic process (GO:0046501)3.48017795
68DNA topological change (GO:0006265)3.47822626
69regulation of sister chromatid cohesion (GO:0007063)3.44822863
70pre-miRNA processing (GO:0031054)3.41766236
71telomere maintenance via recombination (GO:0000722)3.40027708
72negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.39571288
73regulation of centriole replication (GO:0046599)3.39271171
74organ or tissue specific immune response (GO:0002251)3.37449885
75nucleobase biosynthetic process (GO:0046112)3.35219477
76defense response to Gram-positive bacterium (GO:0050830)3.35031280
77regulation of centrosome cycle (GO:0046605)3.32338763
78T-helper 1 type immune response (GO:0042088)3.31933964
79regulation of helicase activity (GO:0051095)3.31647793
80chromosome condensation (GO:0030261)3.31245346
81ATP-dependent chromatin remodeling (GO:0043044)3.27180775
82DNA conformation change (GO:0071103)3.26564810
83postreplication repair (GO:0006301)3.22319267
84immunoglobulin mediated immune response (GO:0016064)3.21998263
85mitotic metaphase plate congression (GO:0007080)3.21403632
86regulation of spindle organization (GO:0090224)3.20293203
87protoporphyrinogen IX biosynthetic process (GO:0006782)3.19318948
88mature B cell differentiation (GO:0002335)3.19209926
89regulation of chromosome segregation (GO:0051983)3.18758304
90metaphase plate congression (GO:0051310)3.17110700
91regulation of B cell apoptotic process (GO:0002902)3.15157257
92microtubule depolymerization (GO:0007019)3.14498656
93telomere maintenance (GO:0000723)3.14432540
94somatic diversification of immune receptors via somatic mutation (GO:0002566)3.12865683
95somatic hypermutation of immunoglobulin genes (GO:0016446)3.12865683
96protein localization to chromosome (GO:0034502)3.12710219
97nucleotide-excision repair, DNA gap filling (GO:0006297)3.11524228
98telomere organization (GO:0032200)3.11242820
99deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.11033193
100DNA replication checkpoint (GO:0000076)3.10188058
101viral transcription (GO:0019083)3.09976471
102spindle checkpoint (GO:0031577)3.08595214
103B cell mediated immunity (GO:0019724)3.06724501
104regulation of RNA export from nucleus (GO:0046831)3.06663585
105viral mRNA export from host cell nucleus (GO:0046784)3.06621511
106regulation of DNA endoreduplication (GO:0032875)3.06107973
107translational termination (GO:0006415)3.04836526
108ribosomal small subunit assembly (GO:0000028)3.04401789
109regulation of mitotic metaphase/anaphase transition (GO:0030071)3.03274492
110spindle assembly checkpoint (GO:0071173)3.02572570
111regulation of mitotic spindle organization (GO:0060236)3.00102333
112regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.99689096
113T cell migration (GO:0072678)2.99588542
114DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.99332202
115DNA synthesis involved in DNA repair (GO:0000731)2.99185838
116regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.96062017
117mitochondrial DNA metabolic process (GO:0032042)2.89941169
118regulation of protein heterodimerization activity (GO:0043497)2.89589524
119chaperone mediated protein folding requiring cofactor (GO:0051085)2.88446121
120proline biosynthetic process (GO:0006561)2.86371665
121positive regulation of alpha-beta T cell proliferation (GO:0046641)2.71866011
122positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.71596877
123positive regulation of B cell differentiation (GO:0045579)2.70788253
124deoxyribonucleotide biosynthetic process (GO:0009263)2.70339045
125B cell proliferation (GO:0042100)2.68379553
126pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.68027081
127histone lysine demethylation (GO:0070076)2.67438139
128DNA ligation (GO:0006266)2.63943663
129T cell lineage commitment (GO:0002360)2.63588253
130histone demethylation (GO:0016577)2.62665862
131maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.60319791
132telomere maintenance via telomere lengthening (GO:0010833)2.57274794
133protein maturation by protein folding (GO:0022417)2.55448544
134ribosomal small subunit biogenesis (GO:0042274)2.52681103
135V(D)J recombination (GO:0033151)2.52253393
136negative thymic T cell selection (GO:0045060)2.49504280
137B cell homeostasis (GO:0001782)2.47201651
138cellular response to interleukin-15 (GO:0071350)2.46799958
139positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.45881146
140negative regulation of DNA repair (GO:0045738)2.45757633
141regulation of hypersensitivity (GO:0002883)2.44763931
142rRNA transcription (GO:0009303)2.39476457
143ribosomal large subunit biogenesis (GO:0042273)2.37127044
144positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.36798764
145double-strand break repair via nonhomologous end joining (GO:0006303)2.35623171
146non-recombinational repair (GO:0000726)2.35623171
147protein demethylation (GO:0006482)2.35442421
148protein dealkylation (GO:0008214)2.35442421

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.95677540
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.50924488
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.16436401
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.89690892
5SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.11663495
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.06052710
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59052160
8* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.31088049
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.21921344
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.19703344
11* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18666047
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.10529622
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00386293
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse15.1903644
15* SOX2_16153702_ChIP-ChIP_HESCs_Human1.91242766
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82731205
17* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.81802064
18* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.78732831
19MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67031342
20SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.64985449
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.64485445
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62358920
23SOX2_18555785_ChIP-Seq_MESCs_Mouse1.62310086
24* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56190431
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51349783
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48741422
27AR_21909140_ChIP-Seq_LNCAP_Human1.44308356
28* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.43407976
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43258382
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.40100057
31* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37957841
32POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33347612
33VDR_23849224_ChIP-Seq_CD4+_Human1.32981420
34* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32340790
35* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30597064
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30182954
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29230980
38* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28258106
39* MAF_26560356_Chip-Seq_TH1_Human1.28106656
40* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27705058
41* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27522204
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26648561
43HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24340479
44* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24226020
45* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.23568882
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22561097
47MYC_22102868_ChIP-Seq_BL_Human1.21374986
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21199176
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19417154
50* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.16854118
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16418299
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14907413
53* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.13076802
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.12002218
55* NANOG_16153702_ChIP-ChIP_HESCs_Human1.10957941
56ELK1_19687146_ChIP-ChIP_HELA_Human1.09670713
57SCL_19346495_ChIP-Seq_HPC-7_Human1.09417367
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08837471
59ZNF263_19887448_ChIP-Seq_K562_Human1.08301300
60XRN2_22483619_ChIP-Seq_HELA_Human1.06542569
61TP63_17297297_ChIP-ChIP_HaCaT_Human1.05339511
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.05161293
63IRF1_19129219_ChIP-ChIP_H3396_Human1.04848107
64MYB_26560356_Chip-Seq_TH1_Human1.02220636
65VDR_24763502_ChIP-Seq_THP-1_Human1.02054762
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01782756
67FOXP3_21729870_ChIP-Seq_TREG_Human0.99940240
68ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99333750
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97696802
70MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96962515
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94417398
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93529768
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92961753
74THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92475374
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91452955
76PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90040304
77KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.88351552
78* UTX_26944678_Chip-Seq_JUKART_Human0.86763248
79YY1_21170310_ChIP-Seq_MESCs_Mouse0.86212128
80ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86204835
81MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.84182222
82CREB1_15753290_ChIP-ChIP_HEK293T_Human0.83754325
83EST1_17652178_ChIP-ChIP_JURKAT_Human0.83571377
84VDR_21846776_ChIP-Seq_THP-1_Human0.83488351
85* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83031271
86* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82527633
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82041815
88NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82032148
89MAF_26560356_Chip-Seq_TH2_Human0.81562000
90STAT4_19710469_ChIP-ChIP_TH1__Mouse0.81006121
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80812391
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78737051
93CIITA_25753668_ChIP-Seq_RAJI_Human0.78178055
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.78156277
95* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76545169
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.76348838
97* MYB_26560356_Chip-Seq_TH2_Human0.74683223
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.74408999
99GATA1_22025678_ChIP-Seq_K562_Human0.74212841
100SPI1_23547873_ChIP-Seq_NB4_Human0.74081496
101NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.72843541
102GABP_17652178_ChIP-ChIP_JURKAT_Human0.72763429
103NANOG_21062744_ChIP-ChIP_HESCs_Human0.72402453
104ETS1_20019798_ChIP-Seq_JURKAT_Human0.72375799
105TTF2_22483619_ChIP-Seq_HELA_Human0.71757079
106SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.71388849
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.70998412
108HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.70318570
109* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.69671863
110GABP_19822575_ChIP-Seq_HepG2_Human0.69559082
111SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.69495942
112GATA1_22383799_ChIP-Seq_G1ME_Mouse0.69124348
113SRF_21415370_ChIP-Seq_HL-1_Mouse0.68794401
114KDM5A_27292631_Chip-Seq_BREAST_Human0.67106000
115TCF3_18692474_ChIP-Seq_MEFs_Mouse0.66806640
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.65919884
117POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.65698268
118RBPJ_22232070_ChIP-Seq_NCS_Mouse0.65538070
119MYC_18940864_ChIP-ChIP_HL60_Human0.64089076
120SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.63639667
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.63038007
122PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.62697637
123KLF4_18555785_ChIP-Seq_MESCs_Mouse0.62688124
124FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.60705272
125TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.60610338
126* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.60542541
127DCP1A_22483619_ChIP-Seq_HELA_Human0.60212152

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.05154146
2MP0003111_abnormal_nucleus_morphology4.44169269
3MP0003077_abnormal_cell_cycle3.81072654
4MP0010307_abnormal_tumor_latency3.76415980
5MP0003693_abnormal_embryo_hatching3.65390096
6MP0008057_abnormal_DNA_replication3.55879029
7MP0004957_abnormal_blastocyst_morpholog3.42332817
8MP0000685_abnormal_immune_system3.41566801
9MP0005645_abnormal_hypothalamus_physiol3.09626795
10MP0010352_gastrointestinal_tract_polyps3.06190705
11MP0003763_abnormal_thymus_physiology3.04624393
12MP0001835_abnormal_antigen_presentation2.72871448
13MP0008058_abnormal_DNA_repair2.65903562
14MP0005671_abnormal_response_to2.56361438
15MP0003123_paternal_imprinting2.47369586
16MP0003656_abnormal_erythrocyte_physiolo2.46573155
17MP0004147_increased_porphyrin_level2.43028219
18MP0000350_abnormal_cell_proliferation2.39350941
19MP0008007_abnormal_cellular_replicative2.26538405
20MP0001800_abnormal_humoral_immune2.24461474
21MP0001730_embryonic_growth_arrest2.23658569
22MP0008932_abnormal_embryonic_tissue2.23040252
23MP0005076_abnormal_cell_differentiation2.22625565
24MP0003705_abnormal_hypodermis_morpholog2.20995115
25MP0003121_genomic_imprinting2.09970872
26MP0006054_spinal_hemorrhage2.07157901
27MP0010234_abnormal_vibrissa_follicle2.04670892
28MP0001661_extended_life_span2.03620085
29MP0002396_abnormal_hematopoietic_system2.01532674
30MP0009379_abnormal_foot_pigmentation1.95313494
31MP0005464_abnormal_platelet_physiology1.89473762
32MP0004197_abnormal_fetal_growth/weight/1.88881426
33MP0002086_abnormal_extraembryonic_tissu1.83421249
34MP0002084_abnormal_developmental_patter1.81842450
35MP0000490_abnormal_crypts_of1.80986598
36MP0004808_abnormal_hematopoietic_stem1.79588541
37MP0001672_abnormal_embryogenesis/_devel1.77979921
38MP0005380_embryogenesis_phenotype1.77979921
39MP0001697_abnormal_embryo_size1.77567049
40MP0005387_immune_system_phenotype1.77284669
41MP0001790_abnormal_immune_system1.77284669
42MP0002085_abnormal_embryonic_tissue1.75976391
43MP0005000_abnormal_immune_tolerance1.75941879
44MP0008877_abnormal_DNA_methylation1.65429530
45MP0002080_prenatal_lethality1.64324530
46MP0002723_abnormal_immune_serum1.61415098
47MP0002420_abnormal_adaptive_immunity1.60747240
48MP0002452_abnormal_antigen_presenting1.59280968
49MP0003984_embryonic_growth_retardation1.55965522
50MP0001819_abnormal_immune_cell1.55581044
51MP0002088_abnormal_embryonic_growth/wei1.53299956
52MP0003786_premature_aging1.51661992
53MP0009333_abnormal_splenocyte_physiolog1.51255347
54MP0000465_gastrointestinal_hemorrhage1.49090055
55MP0000372_irregular_coat_pigmentation1.47884176
56MP0002019_abnormal_tumor_incidence1.45233858
57MP0000313_abnormal_cell_death1.37346920
58MP0001293_anophthalmia1.35597855
59MP0000013_abnormal_adipose_tissue1.33243499
60MP0000537_abnormal_urethra_morphology1.33013041
61MP0003890_abnormal_embryonic-extraembry1.32921240
62MP0003303_peritoneal_inflammation1.32711193
63MP0005025_abnormal_response_to1.28158297
64MP0000703_abnormal_thymus_morphology1.27111940
65MP0003567_abnormal_fetal_cardiomyocyte1.23612220
66MP0010030_abnormal_orbit_morphology1.23473063
67MP0003787_abnormal_imprinting1.21168026
68MP0004947_skin_inflammation1.18940316
69MP0003937_abnormal_limbs/digits/tail_de1.18516337
70MP0005075_abnormal_melanosome_morpholog1.16263968
71MP0004381_abnormal_hair_follicle1.16259267
72MP0000358_abnormal_cell_content/1.14153803
73MP0001915_intracranial_hemorrhage1.13781959
74MP0002111_abnormal_tail_morphology1.12234939
75MP0005220_abnormal_exocrine_pancreas1.11852728
76MP0002722_abnormal_immune_system1.11023601
77MP0002148_abnormal_hypersensitivity_rea1.10344142
78MP0002398_abnormal_bone_marrow1.09399399
79MP0001727_abnormal_embryo_implantation1.07487201
80MP0005623_abnormal_meninges_morphology1.06269693
81MP0000015_abnormal_ear_pigmentation1.06128415
82MP0010155_abnormal_intestine_physiology1.05712340
83MP0001545_abnormal_hematopoietic_system1.05667492
84MP0005397_hematopoietic_system_phenotyp1.05667492
85MP0003806_abnormal_nucleotide_metabolis1.05512942
86MP0009697_abnormal_copulation1.05091658
87MP0001845_abnormal_inflammatory_respons1.04100651
88MP0006035_abnormal_mitochondrial_morpho1.02844272
89MP0002092_abnormal_eye_morphology1.02070677
90MP0003566_abnormal_cell_adhesion1.01534954
91MP0002697_abnormal_eye_size1.01262316
92MP0009703_decreased_birth_body0.99693667
93MP0009053_abnormal_anal_canal0.98126530
94MP0000689_abnormal_spleen_morphology0.98048738
95MP0008770_decreased_survivor_rate0.97871275
96MP0009672_abnormal_birth_weight0.97830986
97MP0002009_preneoplasia0.93956965
98MP0001849_ear_inflammation0.93581591
99MP0009785_altered_susceptibility_to0.88375749
100MP0002925_abnormal_cardiovascular_devel0.88044920
101MP0003183_abnormal_peptide_metabolism0.85498900
102MP0002166_altered_tumor_susceptibility0.85447687
103MP0005310_abnormal_salivary_gland0.85257789
104MP0000733_abnormal_muscle_development0.84446431
105MP0004264_abnormal_extraembryonic_tissu0.83873479
106MP0005621_abnormal_cell_physiology0.83675318
107MP0003119_abnormal_digestive_system0.83667089
108MP0005384_cellular_phenotype0.82481183
109MP0005023_abnormal_wound_healing0.81633698
110MP0010678_abnormal_skin_adnexa0.80081804
111MP0009278_abnormal_bone_marrow0.79723095
112MP0005647_abnormal_sex_gland0.79397198
113MP0001286_abnormal_eye_development0.79090402
114MP0004185_abnormal_adipocyte_glucose0.79062129
115MP0002419_abnormal_innate_immunity0.78578064
116MP0002429_abnormal_blood_cell0.77859649
117MP0000428_abnormal_craniofacial_morphol0.77557590
118MP0002877_abnormal_melanocyte_morpholog0.77280596
119MP0002006_tumorigenesis0.77203171
120MP0003861_abnormal_nervous_system0.76294380
121MP0003941_abnormal_skin_development0.76046839
122MP0005451_abnormal_body_composition0.75691050
123MP0005083_abnormal_biliary_tract0.75647947
124MP0001873_stomach_inflammation0.74484081
125MP0003436_decreased_susceptibility_to0.73751277
126MP0005501_abnormal_skin_physiology0.72881241
127MP0002163_abnormal_gland_morphology0.70534579
128MP0008995_early_reproductive_senescence0.70420796
129MP0000477_abnormal_intestine_morphology0.70017667
130MP0001145_abnormal_male_reproductive0.69934134
131MP0002210_abnormal_sex_determination0.69719897
132MP0000432_abnormal_head_morphology0.68365496
133MP0009046_muscle_twitch0.67140569
134MP0002083_premature_death0.66443036
135MP0000003_abnormal_adipose_tissue0.64659334
136MP0000371_diluted_coat_color0.64454615
137MP0008004_abnormal_stomach_pH0.64201933
138MP0003448_altered_tumor_morphology0.64057084
139MP0009931_abnormal_skin_appearance0.63446080
140MP0003866_abnormal_defecation0.63358628
141MP0004133_heterotaxia0.62488341
142MP0002075_abnormal_coat/hair_pigmentati0.61453325
143MP0001929_abnormal_gametogenesis0.61147761
144MP0000266_abnormal_heart_morphology0.59812282
145MP0008438_abnormal_cutaneous_collagen0.59456052
146MP0003453_abnormal_keratinocyte_physiol0.58762882
147MP0002095_abnormal_skin_pigmentation0.58708821
148MP0003935_abnormal_craniofacial_develop0.56247360
149MP0000716_abnormal_immune_system0.55569220
150MP0003115_abnormal_respiratory_system0.55511515
151MP0000653_abnormal_sex_gland0.54883961
152MP0003283_abnormal_digestive_organ0.53908764

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)6.34368096
2IgA deficiency (HP:0002720)5.90879486
3Colitis (HP:0002583)4.56409545
4Gastrointestinal stroma tumor (HP:0100723)4.49161342
5Dry hair (HP:0011359)4.36882421
6Chromsome breakage (HP:0040012)4.28629278
7Agammaglobulinemia (HP:0004432)4.27571626
8Chromosomal breakage induced by crosslinking agents (HP:0003221)4.27350398
9Recurrent sinusitis (HP:0011108)4.17889492
10Cellulitis (HP:0100658)4.11075590
11Poikilocytosis (HP:0004447)4.07079442
12B lymphocytopenia (HP:0010976)4.00989569
13Reticulocytopenia (HP:0001896)3.82391429
14Hypochromic microcytic anemia (HP:0004840)3.64396837
15Ependymoma (HP:0002888)3.59526740
16Abnormality of chromosome stability (HP:0003220)3.54891595
17Medulloblastoma (HP:0002885)3.54078662
18Abnormality of the heme biosynthetic pathway (HP:0010472)3.53584803
19Abnormality of B cell number (HP:0010975)3.44363462
20Recurrent bronchitis (HP:0002837)3.32115646
21Microvesicular hepatic steatosis (HP:0001414)3.27632030
22Recurrent viral infections (HP:0004429)3.26937519
23Petechiae (HP:0000967)3.26850296
24Abnormality of the labia minora (HP:0012880)3.20455561
25Ridged nail (HP:0001807)3.16917069
26Onycholysis (HP:0001806)3.13940253
27Lymphopenia (HP:0001888)3.12663044
28Colon cancer (HP:0003003)3.10242198
29Agnosia (HP:0010524)3.10186614
30Abnormality of cells of the lymphoid lineage (HP:0012140)3.08317096
31Abnormality of reticulocytes (HP:0004312)3.08314430
32Inflammation of the large intestine (HP:0002037)3.06345590
33Erythema (HP:0010783)3.04367532
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.03636391
35Short 4th metacarpal (HP:0010044)3.03636391
36Birth length less than 3rd percentile (HP:0003561)3.02405986
37Impulsivity (HP:0100710)2.99835097
38Meningitis (HP:0001287)2.99806446
39Astrocytoma (HP:0009592)2.95099976
40Abnormality of the astrocytes (HP:0100707)2.95099976
41Gastrointestinal inflammation (HP:0004386)2.90268964
42Neoplasm of the oral cavity (HP:0100649)2.89578198
43Aplastic anemia (HP:0001915)2.87058877
44Rhabdomyosarcoma (HP:0002859)2.79293174
45Basal cell carcinoma (HP:0002671)2.78080542
46Acanthocytosis (HP:0001927)2.76835850
47Cutaneous melanoma (HP:0012056)2.76016596
48Selective tooth agenesis (HP:0001592)2.74661378
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.74517280
50Aplasia/Hypoplasia of the sacrum (HP:0008517)2.74222279
51Meckel diverticulum (HP:0002245)2.68603985
52Reticulocytosis (HP:0001923)2.66646118
53Chronic diarrhea (HP:0002028)2.59888872
54Mediastinal lymphadenopathy (HP:0100721)2.59423822
55Duodenal stenosis (HP:0100867)2.59122635
56Small intestinal stenosis (HP:0012848)2.59122635
57Panhypogammaglobulinemia (HP:0003139)2.58822666
58Abnormality of cells of the erythroid lineage (HP:0012130)2.57903288
59Abnormality of the ileum (HP:0001549)2.57892148
60Glioma (HP:0009733)2.57783980
61Cafe-au-lait spot (HP:0000957)2.56864590
62Volvulus (HP:0002580)2.55973902
63Abnormality of T cell physiology (HP:0011840)2.53152800
64Lymphoma (HP:0002665)2.50381345
65Ectopic kidney (HP:0000086)2.48386461
66Myelodysplasia (HP:0002863)2.46586076
67High pitched voice (HP:0001620)2.43344749
68Progressive external ophthalmoplegia (HP:0000590)2.43074855
69Leukopenia (HP:0001882)2.41571237
70Abnormality of the preputium (HP:0100587)2.40053586
7111 pairs of ribs (HP:0000878)2.39820737
72Prominent nose (HP:0000448)2.39401526
73IgG deficiency (HP:0004315)2.38550561
74Patellar aplasia (HP:0006443)2.37442095
75Abnormality of the prostate (HP:0008775)2.34225031
76Sparse scalp hair (HP:0002209)2.34152471
77Sandal gap (HP:0001852)2.33140110
78Progressive muscle weakness (HP:0003323)2.31131478
79Increased nuchal translucency (HP:0010880)2.30976608
80Biliary tract neoplasm (HP:0100574)2.28994612
81Missing ribs (HP:0000921)2.28682184
82Neoplasm of striated muscle (HP:0009728)2.27844574
83Duplicated collecting system (HP:0000081)2.26613363
84Absent radius (HP:0003974)2.26459763
85Abnormality of the carotid arteries (HP:0005344)2.25882173
86Osteomyelitis (HP:0002754)2.23983408
87Recurrent bacterial skin infections (HP:0005406)2.23030760
88Abnormal number of erythroid precursors (HP:0012131)2.23021180
89Abnormality of the duodenum (HP:0002246)2.21499972
90Emphysema (HP:0002097)2.21086905
91Absent thumb (HP:0009777)2.20889797
92Autoimmune hemolytic anemia (HP:0001890)2.20630584
93Prostate neoplasm (HP:0100787)2.20142513
94Recurrent pneumonia (HP:0006532)2.20050561
95Sloping forehead (HP:0000340)2.19746098
96Amaurosis fugax (HP:0100576)2.19503762
97Deviation of the thumb (HP:0009603)2.19399475
98Interstitial pulmonary disease (HP:0006530)2.19229026
99Squamous cell carcinoma (HP:0002860)2.19116648
100Cortical dysplasia (HP:0002539)2.18577872
101Deep palmar crease (HP:0006191)2.15608110
102Abnormal platelet volume (HP:0011876)2.12917597
103Macrocytic anemia (HP:0001972)2.11985455
104Proximal placement of thumb (HP:0009623)2.11968314
105Aplasia/Hypoplasia of the patella (HP:0006498)2.11958019
106Abnormality of the fingertips (HP:0001211)2.11853496
107Abnormal gallbladder physiology (HP:0012438)2.11694716
108Cholecystitis (HP:0001082)2.11694716
109Abnormal platelet function (HP:0011869)2.11250575
110Impaired platelet aggregation (HP:0003540)2.11250575
111Heterotopia (HP:0002282)2.11164760
112Pallor (HP:0000980)2.11024038
113Hypergonadotropic hypogonadism (HP:0000815)2.10145573
114Absent forearm bone (HP:0003953)2.08002596
115Aplasia involving forearm bones (HP:0009822)2.08002596
116Thrombocytosis (HP:0001894)2.07109675
117Hyperacusis (HP:0010780)2.06623332
118Abnormal lung lobation (HP:0002101)2.06526615
119Acute hepatic failure (HP:0006554)2.05148575
120Vasculitis (HP:0002633)2.04673968
121Gastrointestinal carcinoma (HP:0002672)2.02667475
122Malignant gastrointestinal tract tumors (HP:0006749)2.02667475
123Poikiloderma (HP:0001029)2.01455278
124Recurrent lower respiratory tract infections (HP:0002783)2.00873794
125Skin rash (HP:0000988)1.98297192
126Abnormality of the 4th metacarpal (HP:0010012)1.97655824
127Recurrent fungal infections (HP:0002841)1.96635035
128Abnormal number of incisors (HP:0011064)1.95961821
129Neoplasm of the pancreas (HP:0002894)1.95708741
130Insomnia (HP:0100785)1.94283479
131Acute lymphatic leukemia (HP:0006721)1.93437414
132Increased mean platelet volume (HP:0011877)1.92846221
133Absent frontal sinuses (HP:0002688)1.92271165
134Urticaria (HP:0001025)1.90970938
135Recurrent abscess formation (HP:0002722)1.90671033
136Lipid accumulation in hepatocytes (HP:0006561)1.90030340
137Long eyelashes (HP:0000527)1.87782597
138Nephroblastoma (Wilms tumor) (HP:0002667)1.87755951
139Short thumb (HP:0009778)1.87626627
140Ragged-red muscle fibers (HP:0003200)1.86015147
141Ulnar bowing (HP:0003031)1.85601523
142Ovarian neoplasm (HP:0100615)1.85570260
143Abnormality of the renal collecting system (HP:0004742)1.83638435
144Increased intramyocellular lipid droplets (HP:0012240)1.83155460
145Hypopigmentation of the fundus (HP:0007894)1.83133420
146Orthostatic hypotension (HP:0001278)1.82968450
147Abnormality of the calcaneus (HP:0008364)1.81948927
148Renovascular hypertension (HP:0100817)1.81547575
149Hepatitis (HP:0012115)1.80934116
150Neutropenia (HP:0001875)1.80304285
151Thyroiditis (HP:0100646)1.80266192
152Hypochromic anemia (HP:0001931)1.79917409
153Clubbing of toes (HP:0100760)1.78429523
154Supernumerary spleens (HP:0009799)1.78378322
155Abnormality of abdominal situs (HP:0011620)1.77946080
156Abdominal situs inversus (HP:0003363)1.77946080
157Abnormality of T cells (HP:0002843)1.77212035
158Abnormal delayed hypersensitivity skin test (HP:0002963)1.76474218
159Aplasia/Hypoplasia of the sternum (HP:0006714)1.76170331
160Skull defect (HP:0001362)1.75770192
161Esophageal atresia (HP:0002032)1.75686626
162Increased muscle lipid content (HP:0009058)1.75552138
163Viral hepatitis (HP:0006562)1.75395732
164Atresia of the external auditory canal (HP:0000413)1.74921628
165Papilloma (HP:0012740)1.74331207
166Verrucae (HP:0200043)1.74331207
167Large earlobe (HP:0009748)1.73934113
168Facial hemangioma (HP:0000329)1.73818774
169Combined immunodeficiency (HP:0005387)1.73614152
170Tracheoesophageal fistula (HP:0002575)1.73130329
171Freckling (HP:0001480)1.72474541
172Embryonal renal neoplasm (HP:0011794)1.71477004
173Abnormality of chromosome segregation (HP:0002916)1.70900241
174Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.69698163
175Pancytopenia (HP:0001876)1.69297574
176Entropion (HP:0000621)1.69161442
177Severe combined immunodeficiency (HP:0004430)1.68954195
178Lower limb hyperreflexia (HP:0002395)1.68645156
179Breast hypoplasia (HP:0003187)1.67220297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.88936387
2ZAK6.39029862
3VRK13.72138650
4CDC73.28041003
5STK42.90924382
6RPS6KA52.67852792
7MAP3K102.11320561
8EEF2K1.98757507
9WEE11.92774994
10NEK21.92561239
11CDK121.89574170
12SCYL21.86638701
13EPHA21.84634871
14CDK91.80433434
15SRPK11.66908060
16PIM11.65548384
17BUB11.65517741
18SMG11.64510604
19AURKB1.59040424
20CHEK21.54223761
21PKN21.54018228
22MAP3K81.47491870
23RPS6KB21.41886248
24BTK1.32606095
25FLT31.24846698
26TTK1.24810981
27DYRK31.21140474
28DAPK31.16496563
29PBK1.15287807
30ATR1.13340773
31EIF2AK11.10220354
32IRAK31.09080720
33PKN11.08229568
34PLK11.04647518
35IRAK41.02833727
36AURKA1.01909626
37BCKDK1.00771641
38NEK10.96001231
39STK160.95154930
40CDK40.91954428
41BRSK20.89928810
42PASK0.89414031
43PRPF4B0.86684042
44SYK0.84679840
45MAP4K10.83173399
46TRIB30.82849960
47MAP3K140.82239382
48PIM20.82206500
49ICK0.80328610
50ACVR1B0.80258640
51CHEK10.79424617
52GRK60.78295160
53CDK70.75998587
54ATM0.74141656
55MELK0.74058226
56STK100.73174004
57MAPK110.69839415
58PLK30.69034849
59TTN0.68926734
60AKT20.66911115
61BRD40.64469993
62CDK20.63697242
63NME20.63394068
64BRAF0.62954064
65CDK80.62676732
66IKBKB0.61273332
67TBK10.57985668
68CDK60.55254339
69CAMK1D0.54849783
70KDR0.53536929
71TGFBR10.50931893
72VRK20.50628170
73BRSK10.49269017
74CDK10.47814364
75LYN0.46300085
76CSNK1D0.44558008
77TAF10.44071788
78CSNK1G30.43418060
79STK30.42178607
80DYRK1B0.41617334
81IKBKE0.35855443
82MTOR0.35599527
83BLK0.35209132
84FGFR20.35076588
85PAK40.34513722
86PAK10.34506257
87MAPKAPK50.33717447
88MKNK10.33609613
89LRRK20.33507407
90PIK3CG0.32946032
91PRKAA10.32679015
92PRKDC0.32643193
93IRAK20.32616269
94ALK0.32472465
95RIPK40.31912191
96JAK10.31057259
97MST40.30956139
98CLK10.30279359
99FRK0.30050469
100JAK20.29808824
101ARAF0.29128577
102PDK20.28658504
103EIF2AK30.28378228
104PLK40.28252015
105TESK20.27693986
106TSSK60.27660153
107RPS6KB10.26842267
108EIF2AK20.25749743
109KSR10.25729055
110CSNK1G10.25431106
111CSNK1A1L0.25188830
112RIPK10.25071067
113CCNB10.24020183
114PAK20.23982212
115MAPK140.23456829
116FGR0.21838058
117HCK0.21483907
118LATS10.21392122
119RPS6KA40.21165342
120CSNK2A20.20950313
121AKT10.20924893
122CSF1R0.20761947
123ROCK10.20044507
124KIT0.19295213
125MAP3K130.18621548
126PRKCI0.18063442
127TEC0.16819351
128MAP2K20.16464654
129MET0.16321920
130JAK30.16269013
131PDGFRA0.15195150
132RPS6KA10.15156335
133MKNK20.14775304
134TRPM70.14596979
135PRKCD0.14096271
136RPS6KC10.13223216
137RPS6KL10.13223216
138MAPK10.12210745
139PRKCQ0.11186597
140MAP2K30.10152572
141GSK3B0.10011638
142BMX0.09726842
143PTK60.09297346
144FGFR10.07801860

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.19120542
2DNA replication_Homo sapiens_hsa030303.27665827
3Viral carcinogenesis_Homo sapiens_hsa052033.26088718
4Mismatch repair_Homo sapiens_hsa034302.86596358
5One carbon pool by folate_Homo sapiens_hsa006702.22059187
6Cell cycle_Homo sapiens_hsa041102.14112947
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02235887
8* Systemic lupus erythematosus_Homo sapiens_hsa0532210.8734590
9Asthma_Homo sapiens_hsa053101.94308710
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.93529324
11Non-homologous end-joining_Homo sapiens_hsa034501.85350099
12RNA transport_Homo sapiens_hsa030131.84155606
13* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.78672707
14Allograft rejection_Homo sapiens_hsa053301.77204321
15Base excision repair_Homo sapiens_hsa034101.76191683
16Nucleotide excision repair_Homo sapiens_hsa034201.74684037
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73178036
18Fanconi anemia pathway_Homo sapiens_hsa034601.71441606
19Homologous recombination_Homo sapiens_hsa034401.70651822
20Autoimmune thyroid disease_Homo sapiens_hsa053201.64415490
21Spliceosome_Homo sapiens_hsa030401.61498482
22Ribosome_Homo sapiens_hsa030101.56503445
23Graft-versus-host disease_Homo sapiens_hsa053321.43183229
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.34385651
25Type I diabetes mellitus_Homo sapiens_hsa049401.21400748
26p53 signaling pathway_Homo sapiens_hsa041151.18002890
27mRNA surveillance pathway_Homo sapiens_hsa030151.16275959
28MicroRNAs in cancer_Homo sapiens_hsa052060.97400759
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96303857
30Pyrimidine metabolism_Homo sapiens_hsa002400.95674695
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90510826
32Leishmaniasis_Homo sapiens_hsa051400.80246298
33Small cell lung cancer_Homo sapiens_hsa052220.80182399
34RNA polymerase_Homo sapiens_hsa030200.79636495
35RNA degradation_Homo sapiens_hsa030180.79238015
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75544401
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72159154
38Selenocompound metabolism_Homo sapiens_hsa004500.71194864
39HTLV-I infection_Homo sapiens_hsa051660.65679420
40Oocyte meiosis_Homo sapiens_hsa041140.65173317
41Chronic myeloid leukemia_Homo sapiens_hsa052200.61781699
42N-Glycan biosynthesis_Homo sapiens_hsa005100.56416558
43Non-small cell lung cancer_Homo sapiens_hsa052230.56149387
44Herpes simplex infection_Homo sapiens_hsa051680.55970958
45Epstein-Barr virus infection_Homo sapiens_hsa051690.52849618
46Bladder cancer_Homo sapiens_hsa052190.52660278
47Lysine degradation_Homo sapiens_hsa003100.52207454
48Fructose and mannose metabolism_Homo sapiens_hsa000510.51659809
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50234308
50Basal transcription factors_Homo sapiens_hsa030220.48922622
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46868731
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46347855
53Apoptosis_Homo sapiens_hsa042100.45538538
54Colorectal cancer_Homo sapiens_hsa052100.44295498
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.42330515
56mTOR signaling pathway_Homo sapiens_hsa041500.42163076
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42068829
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41109363
59Carbon metabolism_Homo sapiens_hsa012000.38867822
60Biosynthesis of amino acids_Homo sapiens_hsa012300.38562707
61Antigen processing and presentation_Homo sapiens_hsa046120.38508852
62Basal cell carcinoma_Homo sapiens_hsa052170.37952776
63Purine metabolism_Homo sapiens_hsa002300.36896156
64Hepatitis B_Homo sapiens_hsa051610.36700912
65Toxoplasmosis_Homo sapiens_hsa051450.34012824
66TGF-beta signaling pathway_Homo sapiens_hsa043500.33644505
67Thyroid cancer_Homo sapiens_hsa052160.33534335
68Renin-angiotensin system_Homo sapiens_hsa046140.32663174
69Notch signaling pathway_Homo sapiens_hsa043300.32024841
70Vitamin B6 metabolism_Homo sapiens_hsa007500.31771833
71Pancreatic cancer_Homo sapiens_hsa052120.29525604
72Hippo signaling pathway_Homo sapiens_hsa043900.29069756
73FoxO signaling pathway_Homo sapiens_hsa040680.28170006
74Staphylococcus aureus infection_Homo sapiens_hsa051500.27936721
75Pentose phosphate pathway_Homo sapiens_hsa000300.27671940
76Melanoma_Homo sapiens_hsa052180.25726250
77Proteoglycans in cancer_Homo sapiens_hsa052050.25572615
78Prostate cancer_Homo sapiens_hsa052150.25268382
79Glioma_Homo sapiens_hsa052140.25240859
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.23671950
81Pathways in cancer_Homo sapiens_hsa052000.23481637
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23130824
83Sulfur relay system_Homo sapiens_hsa041220.22692664
84Hematopoietic cell lineage_Homo sapiens_hsa046400.22525794
85Phenylalanine metabolism_Homo sapiens_hsa003600.21696093
86B cell receptor signaling pathway_Homo sapiens_hsa046620.21462949
87Adherens junction_Homo sapiens_hsa045200.20857667
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.20702031
89Galactose metabolism_Homo sapiens_hsa000520.20681905
90Proteasome_Homo sapiens_hsa030500.20430011
91Endometrial cancer_Homo sapiens_hsa052130.19177173
92Sulfur metabolism_Homo sapiens_hsa009200.18864412
93Rheumatoid arthritis_Homo sapiens_hsa053230.18727651
94Viral myocarditis_Homo sapiens_hsa054160.18587522
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18098462
96Measles_Homo sapiens_hsa051620.17621275
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17135088
98HIF-1 signaling pathway_Homo sapiens_hsa040660.16549384
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16370326
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.16037076
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.16020029
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.15429313
103Tuberculosis_Homo sapiens_hsa051520.15373458
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.14843836
105Tight junction_Homo sapiens_hsa045300.14778809
106Parkinsons disease_Homo sapiens_hsa050120.14609698
107Legionellosis_Homo sapiens_hsa051340.14532343
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.13742819
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.13528369
110Influenza A_Homo sapiens_hsa051640.13361681
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.13255378
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11627125
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.11569397
114Focal adhesion_Homo sapiens_hsa045100.11463081
115Huntingtons disease_Homo sapiens_hsa050160.10181487
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.10097035
117Primary immunodeficiency_Homo sapiens_hsa053400.09816315
118AMPK signaling pathway_Homo sapiens_hsa041520.09704164
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.09314482
120Oxidative phosphorylation_Homo sapiens_hsa001900.09076648
121Platelet activation_Homo sapiens_hsa046110.08608140
122ECM-receptor interaction_Homo sapiens_hsa045120.08450464
123Hedgehog signaling pathway_Homo sapiens_hsa043400.07973681
124Acute myeloid leukemia_Homo sapiens_hsa052210.06670647
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.06650704
126Phagosome_Homo sapiens_hsa041450.06533582
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.06440626
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.06023500
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.05991414
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.05847159
131Wnt signaling pathway_Homo sapiens_hsa043100.04835564
132Inositol phosphate metabolism_Homo sapiens_hsa005620.04244165
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.03275544

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