HIST1H3E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin assembly (GO:0031497)7.05423323
2regulation of histone H3-K9 methylation (GO:0051570)6.81121606
3nucleosome assembly (GO:0006334)6.43624290
4nucleosome organization (GO:0034728)5.58571127
5chromatin assembly or disassembly (GO:0006333)5.54608207
6protein-DNA complex assembly (GO:0065004)5.46867424
7nuclear pore complex assembly (GO:0051292)5.46614706
8DNA unwinding involved in DNA replication (GO:0006268)5.44211761
9nuclear pore organization (GO:0006999)5.35190370
10protein localization to kinetochore (GO:0034501)5.29708084
11antibacterial humoral response (GO:0019731)5.02180689
12protein-DNA complex subunit organization (GO:0071824)4.90653118
13mitotic chromosome condensation (GO:0007076)4.89730648
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.84733593
15innate immune response in mucosa (GO:0002227)4.82981787
16antimicrobial humoral response (GO:0019730)4.69555072
17chromatin remodeling at centromere (GO:0031055)4.64089678
18negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.59591929
19CENP-A containing nucleosome assembly (GO:0034080)4.58781344
20dorsal/ventral axis specification (GO:0009950)4.48190207
21regulation of gene silencing (GO:0060968)4.46981496
22folic acid-containing compound biosynthetic process (GO:0009396)4.46396006
23protein localization to chromosome, centromeric region (GO:0071459)4.44203461
24sister chromatid segregation (GO:0000819)4.33474621
25DNA replication initiation (GO:0006270)4.22697477
26negative regulation of histone methylation (GO:0031061)4.13494263
27pore complex assembly (GO:0046931)4.12035226
28regulation of gene silencing by RNA (GO:0060966)4.06890935
29regulation of posttranscriptional gene silencing (GO:0060147)4.06890935
30regulation of gene silencing by miRNA (GO:0060964)4.06890935
31DNA replication-independent nucleosome organization (GO:0034724)4.03735441
32DNA replication-independent nucleosome assembly (GO:0006336)4.03735441
33replicative senescence (GO:0090399)4.00015635
34IMP biosynthetic process (GO:0006188)3.93261304
35mitotic nuclear envelope disassembly (GO:0007077)3.92485392
36DNA strand elongation involved in DNA replication (GO:0006271)3.91440854
37DNA duplex unwinding (GO:0032508)3.89956875
38lung-associated mesenchyme development (GO:0060484)3.89760544
39DNA geometric change (GO:0032392)3.89257394
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.87354077
41negative regulation of translation, ncRNA-mediated (GO:0040033)3.86223149
42regulation of translation, ncRNA-mediated (GO:0045974)3.86223149
43negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.86223149
44mitotic sister chromatid segregation (GO:0000070)3.84781382
45protein K6-linked ubiquitination (GO:0085020)3.77473811
46nuclear envelope disassembly (GO:0051081)3.72591001
47membrane disassembly (GO:0030397)3.72591001
48DNA strand elongation (GO:0022616)3.72588599
49histone exchange (GO:0043486)3.71219134
50telomere maintenance via semi-conservative replication (GO:0032201)3.65096703
51viral transcription (GO:0019083)3.65023100
52mucosal immune response (GO:0002385)3.62728353
53regulation of centrosome duplication (GO:0010824)3.62458226
54ribosomal small subunit assembly (GO:0000028)3.59383833
55translational termination (GO:0006415)3.58907490
56IMP metabolic process (GO:0046040)3.55476334
57DNA topological change (GO:0006265)3.52197412
58mitotic recombination (GO:0006312)3.51321165
59dosage compensation (GO:0007549)3.50447450
60histone lysine demethylation (GO:0070076)3.47868885
61epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.46991944
62regulation of helicase activity (GO:0051095)3.41689768
63organ or tissue specific immune response (GO:0002251)3.41462014
64histone demethylation (GO:0016577)3.38880136
65paraxial mesoderm development (GO:0048339)3.36730390
66chromosome condensation (GO:0030261)3.36374684
67translesion synthesis (GO:0019985)3.35799249
68regulation of translational fidelity (GO:0006450)3.33085698
69positive regulation of histone methylation (GO:0031062)3.31938348
70positive regulation of chromosome segregation (GO:0051984)3.30593950
71meiotic chromosome segregation (GO:0045132)3.30297730
72anterior/posterior axis specification, embryo (GO:0008595)3.27502161
73telomere maintenance via recombination (GO:0000722)3.26030750
74regulation of centriole replication (GO:0046599)3.25829780
75kinetochore organization (GO:0051383)3.25040409
76DNA conformation change (GO:0071103)3.23890546
77telomere maintenance (GO:0000723)3.22821377
78DNA double-strand break processing (GO:0000729)3.22706037
79mRNA cleavage (GO:0006379)3.21487585
80pre-miRNA processing (GO:0031054)3.20192047
81viral mRNA export from host cell nucleus (GO:0046784)3.19669331
82telomere organization (GO:0032200)3.19552031
83regulation of centrosome cycle (GO:0046605)3.16102399
84inner cell mass cell proliferation (GO:0001833)3.15746254
85gastrulation with mouth forming second (GO:0001702)3.14496306
86nucleobase biosynthetic process (GO:0046112)3.14195000
87translational elongation (GO:0006414)3.14118842
88ATP-dependent chromatin remodeling (GO:0043044)3.13834638
89mitotic sister chromatid cohesion (GO:0007064)3.12868768
90regulation of megakaryocyte differentiation (GO:0045652)3.12251325
91protein prenylation (GO:0018342)3.11139578
92prenylation (GO:0097354)3.11139578
93maturation of SSU-rRNA (GO:0030490)3.10367880
94regulation of spindle organization (GO:0090224)3.10162346
95somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09114752
96somatic hypermutation of immunoglobulin genes (GO:0016446)3.09114752
97metaphase plate congression (GO:0051310)3.08327498
98mitotic metaphase plate congression (GO:0007080)3.08294547
99nucleotide-excision repair, DNA gap filling (GO:0006297)3.07760347
100protein dealkylation (GO:0008214)3.06088923
101protein demethylation (GO:0006482)3.06088923
102regulation of sister chromatid cohesion (GO:0007063)3.04590302
103ribosomal large subunit biogenesis (GO:0042273)3.03954112
104nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02782391
105translational initiation (GO:0006413)3.02680851
106positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.00440748
107positive regulation of mitotic sister chromatid separation (GO:1901970)3.00440748
108positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.00440748
109postreplication repair (GO:0006301)3.00106265
110regulation of chromosome segregation (GO:0051983)2.99394818
111double-strand break repair via nonhomologous end joining (GO:0006303)2.98878766
112non-recombinational repair (GO:0000726)2.98878766
113attachment of spindle microtubules to kinetochore (GO:0008608)2.97765139
114protein localization to chromosome (GO:0034502)2.96662497
115negative regulation of DNA repair (GO:0045738)2.95485496
116DNA packaging (GO:0006323)2.93712095
117branching involved in labyrinthine layer morphogenesis (GO:0060670)2.93710619
118protein complex localization (GO:0031503)2.91664016
119spindle checkpoint (GO:0031577)2.91417418
120positive regulation of SMAD protein import into nucleus (GO:0060391)2.82617069
121somatic recombination of immunoglobulin gene segments (GO:0016447)2.81157272
122regulation of cell fate specification (GO:0042659)2.80296414
123male genitalia development (GO:0030539)2.80121750
124regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.73462373
125negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.71731667
126embryonic foregut morphogenesis (GO:0048617)2.67593969
127DNA replication checkpoint (GO:0000076)2.66144323
128synapsis (GO:0007129)2.65688773
129regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.65644873
130regulation of mitotic sister chromatid separation (GO:0010965)2.62468232
131regulation of mitotic sister chromatid segregation (GO:0033047)2.62468232
132regulation of sister chromatid segregation (GO:0033045)2.62468232
133replication fork processing (GO:0031297)2.61392826
134negative regulation of chromosome segregation (GO:0051985)2.60830774
135regulation of DNA endoreduplication (GO:0032875)2.60088933
136regulation of DNA damage checkpoint (GO:2000001)2.59703101
137embryonic hindlimb morphogenesis (GO:0035116)2.57248293
138regulation of hippo signaling (GO:0035330)2.55310526
139negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.54669175
140negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.54669175
141negative regulation of mitotic sister chromatid segregation (GO:0033048)2.54669175
142negative regulation of mitotic sister chromatid separation (GO:2000816)2.54669175
143negative regulation of sister chromatid segregation (GO:0033046)2.54669175
144sulfation (GO:0051923)2.53897845
145regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.52965360
146regulation of mitotic metaphase/anaphase transition (GO:0030071)2.52965360
147lymphangiogenesis (GO:0001946)2.52679936
148somatic diversification of immunoglobulins (GO:0016445)2.52179336
149ncRNA catabolic process (GO:0034661)2.51911228
150regulation of mesoderm development (GO:2000380)2.51451991
151behavioral response to nicotine (GO:0035095)2.50102568
152artery development (GO:0060840)2.49464072
153maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.45751304
154DNA replication-dependent nucleosome organization (GO:0034723)10.1702348
155DNA replication-dependent nucleosome assembly (GO:0006335)10.1702348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.51921928
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.21391119
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.16450022
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.09933961
5SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.04250394
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.85465358
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.46681640
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28777714
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.27807324
10* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.27740341
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.15008755
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.02935373
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.01475709
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse15.2445440
15* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99750974
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98100586
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85328670
18* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.84153236
19* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.82148661
20* SOX2_16153702_ChIP-ChIP_HESCs_Human1.81125761
21MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73870323
22IRF1_19129219_ChIP-ChIP_H3396_Human1.73840391
23* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66866806
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62145985
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.60811888
26* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.57551324
27SOX2_18555785_ChIP-Seq_MESCs_Mouse1.55509469
28* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45564049
29HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45118677
30* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.43885125
31VDR_23849224_ChIP-Seq_CD4+_Human1.43766052
32* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42325665
33* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39633862
34* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39278463
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37172756
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32490131
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31038093
38HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29844344
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29196678
40AR_21909140_ChIP-Seq_LNCAP_Human1.28973434
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27959863
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26833663
43* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24786776
44KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24217520
45GBX2_23144817_ChIP-Seq_PC3_Human1.23758825
46ELK1_19687146_ChIP-ChIP_HELA_Human1.23135597
47MYC_22102868_ChIP-Seq_BL_Human1.22401847
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22321560
49* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21042028
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17646891
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16635340
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16307439
53TCF3_18692474_ChIP-Seq_MESCs_Mouse1.15443679
54HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13941971
55POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.13887319
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13559974
57EWS_26573619_Chip-Seq_HEK293_Human1.12945003
58XRN2_22483619_ChIP-Seq_HELA_Human1.12180179
59FOXP3_21729870_ChIP-Seq_TREG_Human1.08674486
60HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08484945
61* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.08194810
62* NANOG_16153702_ChIP-ChIP_HESCs_Human1.06337730
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.05143672
64FUS_26573619_Chip-Seq_HEK293_Human1.04689865
65STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99943456
66MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98386573
67SOX9_26525672_Chip-Seq_HEART_Mouse0.97141718
68ZNF274_21170338_ChIP-Seq_K562_Hela0.95814197
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95209445
70KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.94231410
71CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92030394
72PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91592265
73VDR_21846776_ChIP-Seq_THP-1_Human0.90856015
74NOTCH1_21737748_ChIP-Seq_TLL_Human0.90740934
75THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89728588
76* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89609832
77ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89542875
78RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89263902
79BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89253708
80GATA1_26923725_Chip-Seq_HPCs_Mouse0.89252797
81EST1_17652178_ChIP-ChIP_JURKAT_Human0.89171361
82* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88891257
83TDRD3_21172665_ChIP-Seq_MCF-7_Human0.88862915
84TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.86516695
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86353018
86PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86114425
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85555250
88TP63_19390658_ChIP-ChIP_HaCaT_Human0.84432314
89POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84114877
90FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.83340379
91MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.83226245
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.83221078
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.83184397
94VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.82427403
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82032641
96ETS1_20019798_ChIP-Seq_JURKAT_Human0.81910109
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.81854929
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81623118
99CIITA_25753668_ChIP-Seq_RAJI_Human0.81509370
100CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81095115
101AR_21572438_ChIP-Seq_LNCaP_Human0.79564333
102KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.79310012
103KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.79310012
104KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.79310012
105TTF2_22483619_ChIP-Seq_HELA_Human0.78908858
106P300_19829295_ChIP-Seq_ESCs_Human0.76791060
107* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.76176549
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.75868941
109ETS1_22383799_ChIP-Seq_G1ME_Mouse0.75756088
110IGF1R_20145208_ChIP-Seq_DFB_Human0.74779575
111TAF15_26573619_Chip-Seq_HEK293_Human0.74270980
112* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.71891503
113MYC_18940864_ChIP-ChIP_HL60_Human0.71333605
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.70649593
115GABP_17652178_ChIP-ChIP_JURKAT_Human0.70297337
116SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.70006063
117PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.69822086
118GATA1_22025678_ChIP-Seq_K562_Human0.69001407
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.67909589
120PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.67416409
121LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.66720482
122* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.66227371
123SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.66210411
124NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.65972279
125NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.65829473
126ZNF217_24962896_ChIP-Seq_MCF-7_Human0.65745067
127NANOG_21062744_ChIP-ChIP_HESCs_Human0.65373064
128KDM5A_27292631_Chip-Seq_BREAST_Human0.64867319
129* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.64846205
130NANOG_18692474_ChIP-Seq_MESCs_Mouse0.63748275
131DCP1A_22483619_ChIP-Seq_HELA_Human0.63112554
132NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.62663674
133TCF3_18692474_ChIP-Seq_MEFs_Mouse0.61669288
134MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.61445722
135ZFP57_27257070_Chip-Seq_ESCs_Mouse0.60573364
136NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.59941151
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.58538344
138RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.58217914
139STAT6_21828071_ChIP-Seq_BEAS2B_Human0.57228490
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.56406332
141SOX17_20123909_ChIP-Seq_XEN_Mouse0.56221579
142* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.55710409
143AHR_22903824_ChIP-Seq_MCF-7_Human0.54542289
144FOXM1_26456572_ChIP-Seq_MCF-7_Human0.54103997
145SMAD3_21741376_ChIP-Seq_EPCs_Human0.53274142
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.52197760

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.05851619
2MP0003111_abnormal_nucleus_morphology4.19216524
3MP0003077_abnormal_cell_cycle3.78544483
4MP0003693_abnormal_embryo_hatching3.68666827
5MP0010307_abnormal_tumor_latency3.68212836
6MP0004957_abnormal_blastocyst_morpholog3.28338721
7MP0008057_abnormal_DNA_replication3.25471121
8MP0010352_gastrointestinal_tract_polyps2.91090496
9MP0008058_abnormal_DNA_repair2.62008026
10MP0002254_reproductive_system_inflammat2.60965816
11MP0003123_paternal_imprinting2.48577444
12MP0008007_abnormal_cellular_replicative2.38143047
13MP0000569_abnormal_digit_pigmentation2.33548113
14MP0000350_abnormal_cell_proliferation2.29263540
15MP0006054_spinal_hemorrhage2.20256629
16MP0008932_abnormal_embryonic_tissue2.19112645
17MP0003705_abnormal_hypodermis_morpholog2.14230182
18MP0010234_abnormal_vibrissa_follicle2.13609465
19MP0005076_abnormal_cell_differentiation2.12809892
20MP0004808_abnormal_hematopoietic_stem2.11059205
21MP0002396_abnormal_hematopoietic_system2.09438921
22MP0001730_embryonic_growth_arrest2.08498164
23MP0003718_maternal_effect2.07416171
24MP0002638_abnormal_pupillary_reflex2.02100691
25MP0003121_genomic_imprinting2.00363899
26MP0000490_abnormal_crypts_of1.97674872
27MP0002938_white_spotting1.86662859
28MP0002160_abnormal_reproductive_system1.81813068
29MP0000383_abnormal_hair_follicle1.81105484
30MP0004197_abnormal_fetal_growth/weight/1.78966797
31MP0001697_abnormal_embryo_size1.69681839
32MP0002086_abnormal_extraembryonic_tissu1.67989150
33MP0002084_abnormal_developmental_patter1.63913743
34MP0003315_abnormal_perineum_morphology1.63386858
35MP0001672_abnormal_embryogenesis/_devel1.62313590
36MP0005380_embryogenesis_phenotype1.62313590
37MP0002085_abnormal_embryonic_tissue1.61171415
38MP0009384_cardiac_valve_regurgitation1.59180051
39MP0004272_abnormal_basement_membrane1.58163532
40MP0002080_prenatal_lethality1.56397273
41MP0006292_abnormal_olfactory_placode1.55631817
42MP0002019_abnormal_tumor_incidence1.52804922
43MP0001299_abnormal_eye_distance/1.50166830
44MP0002009_preneoplasia1.49756505
45MP0008877_abnormal_DNA_methylation1.47431837
46MP0000703_abnormal_thymus_morphology1.42730670
47MP0002166_altered_tumor_susceptibility1.42071327
48MP0002751_abnormal_autonomic_nervous1.41367676
49MP0003984_embryonic_growth_retardation1.40912235
50MP0002088_abnormal_embryonic_growth/wei1.38868592
51MP0003786_premature_aging1.38638266
52MP0002233_abnormal_nose_morphology1.38027843
53MP0001293_anophthalmia1.37399942
54MP0000313_abnormal_cell_death1.36708868
55MP0005083_abnormal_biliary_tract1.31898033
56MP0002006_tumorigenesis1.28991271
57MP0002398_abnormal_bone_marrow1.28254008
58MP0000537_abnormal_urethra_morphology1.28142396
59MP0000566_synostosis1.27837971
60MP0005391_vision/eye_phenotype1.27594917
61MP0004133_heterotaxia1.27061006
62MP0002722_abnormal_immune_system1.25668620
63MP0005253_abnormal_eye_physiology1.21870889
64MP0000049_abnormal_middle_ear1.21645708
65MP0000427_abnormal_hair_cycle1.21500843
66MP0000579_abnormal_nail_morphology1.17742666
67MP0003935_abnormal_craniofacial_develop1.17728031
68MP0003567_abnormal_fetal_cardiomyocyte1.15683856
69MP0003656_abnormal_erythrocyte_physiolo1.15207196
70MP0000689_abnormal_spleen_morphology1.14903417
71MP0005248_abnormal_Harderian_gland1.11655790
72MP0001915_intracranial_hemorrhage1.09912881
73MP0002095_abnormal_skin_pigmentation1.09097663
74MP0001545_abnormal_hematopoietic_system1.08041996
75MP0005397_hematopoietic_system_phenotyp1.08041996
76MP0009250_abnormal_appendicular_skeleto1.06760780
77MP0003937_abnormal_limbs/digits/tail_de1.05883976
78MP0005187_abnormal_penis_morphology1.05793764
79MP0002111_abnormal_tail_morphology1.05748798
80MP0000371_diluted_coat_color1.05082844
81MP0000432_abnormal_head_morphology1.04763313
82MP0003755_abnormal_palate_morphology1.04600410
83MP0003861_abnormal_nervous_system1.04124423
84MP0002092_abnormal_eye_morphology1.03843405
85MP0005389_reproductive_system_phenotype1.01466353
86MP0000733_abnormal_muscle_development1.01389199
87MP0004147_increased_porphyrin_level1.01042875
88MP0005197_abnormal_uvea_morphology1.00202924
89MP0002075_abnormal_coat/hair_pigmentati0.98276821
90MP0002697_abnormal_eye_size0.97949901
91MP0003806_abnormal_nucleotide_metabolis0.97840281
92MP0003890_abnormal_embryonic-extraembry0.95867474
93MP0010030_abnormal_orbit_morphology0.93941385
94MP0003941_abnormal_skin_development0.93704883
95MP0008770_decreased_survivor_rate0.92676999
96MP0002089_abnormal_postnatal_growth/wei0.92671234
97MP0002877_abnormal_melanocyte_morpholog0.92317498
98MP0000762_abnormal_tongue_morphology0.92263096
99MP0002429_abnormal_blood_cell0.92249593
100MP0002653_abnormal_ependyma_morphology0.92177161
101MP0003787_abnormal_imprinting0.92154484
102MP0004233_abnormal_muscle_weight0.90828391
103MP0003385_abnormal_body_wall0.89509415
104MP0001800_abnormal_humoral_immune0.89216939
105MP0003136_yellow_coat_color0.88333114
106MP0009703_decreased_birth_body0.88106342
107MP0004264_abnormal_extraembryonic_tissu0.87166769
108MP0002102_abnormal_ear_morphology0.86794211
109MP0003942_abnormal_urinary_system0.86724362
110MP0002116_abnormal_craniofacial_bone0.86265623
111MP0000631_abnormal_neuroendocrine_gland0.84135481
112MP0000685_abnormal_immune_system0.82620397
113MP0005647_abnormal_sex_gland0.80457244
114MP0000716_abnormal_immune_system0.80165603
115MP0009672_abnormal_birth_weight0.79707780
116MP0009053_abnormal_anal_canal0.78215772
117MP0000372_irregular_coat_pigmentation0.78174008
118MP0005367_renal/urinary_system_phenotyp0.77910646
119MP0000516_abnormal_urinary_system0.77910646
120MP0002925_abnormal_cardiovascular_devel0.77096653
121MP0005384_cellular_phenotype0.75719449
122MP0005621_abnormal_cell_physiology0.75649985
123MP0003763_abnormal_thymus_physiology0.75430976
124MP0000477_abnormal_intestine_morphology0.73527351
125MP0001286_abnormal_eye_development0.73436186
126MP0005023_abnormal_wound_healing0.72695442
127MP0001145_abnormal_male_reproductive0.72573032
128MP0002210_abnormal_sex_determination0.72489256
129MP0002109_abnormal_limb_morphology0.72304383
130MP0002452_abnormal_antigen_presenting0.70559673
131MP0001485_abnormal_pinna_reflex0.69837467
132MP0000462_abnormal_digestive_system0.69109185
133MP0003119_abnormal_digestive_system0.69007706
134MP0001340_abnormal_eyelid_morphology0.68853097
135MP0001849_ear_inflammation0.68743758
136MP0001346_abnormal_lacrimal_gland0.68339607
137MP0005623_abnormal_meninges_morphology0.68281096
138MP0003566_abnormal_cell_adhesion0.67963779
139MP0001919_abnormal_reproductive_system0.67797197
140MP0001119_abnormal_female_reproductive0.67610237
141MP0010678_abnormal_skin_adnexa0.67362920
142MP0002420_abnormal_adaptive_immunity0.66312688
143MP0006072_abnormal_retinal_apoptosis0.65318325
144MP0009333_abnormal_splenocyte_physiolog0.65252004
145MP0000428_abnormal_craniofacial_morphol0.64788507
146MP0001819_abnormal_immune_cell0.64444026
147MP0001835_abnormal_antigen_presentation0.64300619
148MP0004185_abnormal_adipocyte_glucose0.64154842
149MP0009278_abnormal_bone_marrow0.63984955
150MP0001929_abnormal_gametogenesis0.63155027

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.16202411
2Chromsome breakage (HP:0040012)4.04250107
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.93778849
4Ependymoma (HP:0002888)3.73343986
5Abnormality of chromosome stability (HP:0003220)3.43809761
6Medulloblastoma (HP:0002885)3.39157570
7Colon cancer (HP:0003003)3.32215378
8Agnosia (HP:0010524)3.31799655
9Cutaneous melanoma (HP:0012056)3.16858118
10Oral leukoplakia (HP:0002745)3.14529835
11Rhabdomyosarcoma (HP:0002859)3.09582286
12Impulsivity (HP:0100710)3.08889864
13Abnormality of the astrocytes (HP:0100707)2.99527297
14Astrocytoma (HP:0009592)2.99527297
15Birth length less than 3rd percentile (HP:0003561)2.99151441
16Basal cell carcinoma (HP:0002671)2.88396492
17Cutaneous finger syndactyly (HP:0010554)2.81197107
18Short 4th metacarpal (HP:0010044)2.79711855
19Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.79711855
20Abnormality of the labia minora (HP:0012880)2.78732106
21Abnormality of cells of the erythroid lineage (HP:0012130)2.76382318
22Neoplasm of the oral cavity (HP:0100649)2.75673002
23Embryonal renal neoplasm (HP:0011794)2.73293286
24Selective tooth agenesis (HP:0001592)2.70635410
25Cutaneous syndactyly (HP:0012725)2.68383292
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.65771801
27Poikilocytosis (HP:0004447)2.60664406
28Meckel diverticulum (HP:0002245)2.58232371
29Amaurosis fugax (HP:0100576)2.56383357
30Cafe-au-lait spot (HP:0000957)2.54300937
31Myelodysplasia (HP:0002863)2.53491158
32Biliary tract neoplasm (HP:0100574)2.52893062
33Abnormality of reticulocytes (HP:0004312)2.51357971
34Glioma (HP:0009733)2.50495804
35Prominent nose (HP:0000448)2.50122535
36Abnormality of the ileum (HP:0001549)2.49344948
37Pallor (HP:0000980)2.46202946
38Hypopigmentation of the fundus (HP:0007894)2.45586177
39High anterior hairline (HP:0009890)2.44267354
40Abnormal number of erythroid precursors (HP:0012131)2.41063677
41Chronic hepatic failure (HP:0100626)2.40674436
42Abnormality of the phalanges of the 2nd finger (HP:0009541)2.40639774
43Macrocytic anemia (HP:0001972)2.39845450
44Neoplasm of striated muscle (HP:0009728)2.36765662
45Stenosis of the external auditory canal (HP:0000402)2.36044279
46Spastic diplegia (HP:0001264)2.35815809
47Duodenal stenosis (HP:0100867)2.33092379
48Small intestinal stenosis (HP:0012848)2.33092379
49Abnormality of the preputium (HP:0100587)2.32234877
50Sloping forehead (HP:0000340)2.31489705
51Freckling (HP:0001480)2.31335673
5211 pairs of ribs (HP:0000878)2.30993040
53Sandal gap (HP:0001852)2.29863046
54Volvulus (HP:0002580)2.26769027
55Bifid tongue (HP:0010297)2.26742652
56Rectal prolapse (HP:0002035)2.26699864
57Cortical dysplasia (HP:0002539)2.25872805
58Abnormality of the fingertips (HP:0001211)2.23862326
59Hypochromic microcytic anemia (HP:0004840)2.23789812
60Thrombocytosis (HP:0001894)2.23184963
61Acanthocytosis (HP:0001927)2.22648345
62Abnormality of the carotid arteries (HP:0005344)2.21275384
63Gastrointestinal carcinoma (HP:0002672)2.20478522
64Malignant gastrointestinal tract tumors (HP:0006749)2.20478522
65High pitched voice (HP:0001620)2.20386094
66Partial agenesis of the corpus callosum (HP:0001338)2.18316617
67Hepatoblastoma (HP:0002884)2.17530587
68Missing ribs (HP:0000921)2.16938671
69Absent forearm bone (HP:0003953)2.16594944
70Aplasia involving forearm bones (HP:0009822)2.16594944
71Increased nuchal translucency (HP:0010880)2.15695368
72Septo-optic dysplasia (HP:0100842)2.14715823
73Absent thumb (HP:0009777)2.14392168
74Coronal craniosynostosis (HP:0004440)2.12550887
75Clubbing of toes (HP:0100760)2.12537542
76Anal stenosis (HP:0002025)2.10243773
77Bilateral microphthalmos (HP:0007633)2.10064541
78Protruding tongue (HP:0010808)2.09674856
79Abnormality of the heme biosynthetic pathway (HP:0010472)2.09655707
80Hypoplasia of the pons (HP:0012110)2.08030326
81Myelomeningocele (HP:0002475)2.07546377
82Deviation of the thumb (HP:0009603)2.06907935
83Facial cleft (HP:0002006)2.06800457
84Neoplasm of the pancreas (HP:0002894)2.06184068
85Horseshoe kidney (HP:0000085)2.05753005
86Patellar aplasia (HP:0006443)2.05677690
87Carpal bone hypoplasia (HP:0001498)2.05162028
88Abnormality of the duodenum (HP:0002246)2.03346987
89Thyroiditis (HP:0100646)2.02002445
90Chorioretinal atrophy (HP:0000533)2.01867026
91Proximal placement of thumb (HP:0009623)2.00559696
92Triphalangeal thumb (HP:0001199)1.99201224
93Ectopic kidney (HP:0000086)1.98769729
94Abnormal number of incisors (HP:0011064)1.98347144
95Arteriovenous malformation (HP:0100026)1.97219841
96Poikiloderma (HP:0001029)1.97104714
97Duplicated collecting system (HP:0000081)1.96533116
98Subacute progressive viral hepatitis (HP:0006572)1.96275600
99Squamous cell carcinoma (HP:0002860)1.95341732
100Absent frontal sinuses (HP:0002688)1.93778791
101Pendular nystagmus (HP:0012043)1.93444970
102Uterine neoplasm (HP:0010784)1.93158207
103IgA deficiency (HP:0002720)1.91811296
104Abnormality of alanine metabolism (HP:0010916)1.90513307
105Hyperalaninemia (HP:0003348)1.90513307
106Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90513307
107Renovascular hypertension (HP:0100817)1.90241177
108Anophthalmia (HP:0000528)1.89993205
109Leiomyosarcoma (HP:0100243)1.88951047
110Uterine leiomyosarcoma (HP:0002891)1.88951047
111Facial asymmetry (HP:0000324)1.88911496
112Abnormality of the proximal phalanges of the hand (HP:0009834)1.88799789
113Breast carcinoma (HP:0003002)1.88431895
114Aplasia/Hypoplasia of the sternum (HP:0006714)1.87887505
115Absent radius (HP:0003974)1.87697985
116Heterotopia (HP:0002282)1.87684664
117Lymphoma (HP:0002665)1.87560006
118Hematochezia (HP:0002573)1.87323576
119Ovarian neoplasm (HP:0100615)1.87012857
120Skull defect (HP:0001362)1.86448345
121Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86204732
122Neoplasm of the adrenal cortex (HP:0100641)1.85966825
123Abnormality of DNA repair (HP:0003254)1.85853960
124Duplication of thumb phalanx (HP:0009942)1.85809418
125Abnormality of the 2nd finger (HP:0004100)1.84945750
126Aplasia/Hypoplasia of the patella (HP:0006498)1.83845383
127Ulnar bowing (HP:0003031)1.82328105
128Abnormality of the salivary glands (HP:0010286)1.81882120
129Abnormal lung lobation (HP:0002101)1.80967318
130Papilloma (HP:0012740)1.80956905
131Verrucae (HP:0200043)1.80956905
132Nephroblastoma (Wilms tumor) (HP:0002667)1.80666378
133Atresia of the external auditory canal (HP:0000413)1.80570082
134Asymmetry of the thorax (HP:0001555)1.80400753
135Choanal stenosis (HP:0000452)1.79962481
136Abnormality of the 4th metacarpal (HP:0010012)1.79960051
137Small hand (HP:0200055)1.79801921
138Intestinal atresia (HP:0011100)1.79639468
139Benign neoplasm of the central nervous system (HP:0100835)1.79431578
140Cellular immunodeficiency (HP:0005374)1.78920053
141Persistence of primary teeth (HP:0006335)1.77692217
142Short hallux (HP:0010109)1.77465427
143Cupped ear (HP:0000378)1.76488867
144Gastrointestinal atresia (HP:0002589)1.75950218
145IgM deficiency (HP:0002850)1.75717713
146Bone marrow hypocellularity (HP:0005528)1.75580142
147Hypoplastic pelvis (HP:0008839)1.75568878
148Abnormality of the pons (HP:0007361)1.75467289
149Preaxial foot polydactyly (HP:0001841)1.75288955
150Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75040742
151Esophageal atresia (HP:0002032)1.74955675
152Large earlobe (HP:0009748)1.74362935
153Intestinal polyposis (HP:0200008)1.72527618
154Intestinal polyp (HP:0005266)1.72244422
155Short thumb (HP:0009778)1.72115775
156Bicornuate uterus (HP:0000813)1.72001464
157Tracheoesophageal fistula (HP:0002575)1.71913946
158Cellulitis (HP:0100658)1.71830789
159Cutis marmorata (HP:0000965)1.71824345
160Abnormality of pyrimidine metabolism (HP:0004353)1.70646239
161Hypoplasia of the thymus (HP:0000778)1.70537751
162Hyperacusis (HP:0010780)1.70034244
1632-3 toe syndactyly (HP:0004691)1.66605540

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK6.23668244
2VRK13.71236252
3CDC72.85802728
4STK42.76473321
5RPS6KA52.65320452
6MAP3K102.28834502
7WEE12.15472719
8TAF12.03964783
9SCYL22.03433691
10NEK22.01005711
11TLK110.2547993
12PKN21.95250835
13CDK91.80299033
14PIM11.76516003
15EEF2K1.66674937
16CDK121.61377632
17BUB11.58619653
18SRPK11.56748173
19MAP3K41.54409852
20RPS6KB21.52498336
21MAP3K81.50999399
22AURKB1.43753573
23FLT31.43748261
24CHEK21.41923254
25MAP2K71.39649009
26EPHA21.27758869
27DYRK31.24749497
28CASK1.14556011
29ACVR1B1.07848602
30DAPK31.05059873
31ATR1.01648149
32PKN10.99428808
33PLK10.97140177
34GRK60.94127879
35TTK0.93836938
36NEK10.92953053
37AURKA0.89580360
38PBK0.88792581
39CDK40.84600886
40PASK0.82751843
41BRSK20.82647680
42BMPR1B0.78195665
43CDK70.76797970
44LATS10.75944384
45NUAK10.75229301
46EIF2AK30.74530654
47STK100.71587683
48STK38L0.70894647
49MELK0.70632423
50CHEK10.69823275
51AKT30.68434681
52SMG10.67689369
53SGK20.66448423
54BRD40.65380651
55LATS20.64333505
56ATM0.63809518
57CSNK1G10.62444195
58EIF2AK10.62165166
59DYRK1B0.61534294
60CAMK1G0.60809163
61NME20.59847068
62PLK30.59544753
63AKT20.59377325
64ADRBK20.58429731
65TGFBR10.58077177
66NLK0.56590816
67SGK2230.56389025
68SGK4940.56389025
69CDK20.54243300
70MAP2K40.53942978
71TTN0.53373082
72CAMK1D0.52998768
73LRRK20.52215088
74CDK60.50320933
75FGFR10.48702056
76INSRR0.48474016
77MKNK20.47429917
78CSNK1A1L0.47293825
79SGK30.46580589
80WNK30.44650962
81NEK90.44100945
82TSSK60.43361428
83MKNK10.41368970
84CAMK40.41177078
85GRK10.40994946
86MAP4K10.38607179
87CDK10.38536058
88PAK40.37877941
89EPHA40.37750901
90STK30.36479422
91CSNK1D0.35786540
92JAK20.34625380
93KSR10.34260456
94EIF2AK20.34106995
95CSF1R0.34045702
96ICK0.32890916
97TYRO30.31124010
98STK240.31075583
99RPS6KA40.30899187
100EPHA30.30863521
101CSNK1G30.30832635
102OBSCN0.30600024
103BMX0.30317177
104PAK10.30240992
105CSNK1G20.28926179
106PIK3CA0.28652474
107MAP3K90.28644515
108RET0.28002005
109MTOR0.27735187
110BRSK10.27627226
111FRK0.27229394
112PRKAA10.26637223
113MET0.26078656
114FGFR20.25875258
115PRKDC0.24939356
116RAF10.23675648
117PDGFRB0.22023380
118FGR0.21884031
119FER0.21716135
120MARK30.21698827
121RPS6KA60.21674972
122TRIB30.21417756
123ALK0.21078284
124CSNK2A20.20779240
125CLK10.20478653
126PRKCE0.20085396
127RPS6KB10.18399318
128ERBB20.18240084
129MAPK140.18161147
130RIPK10.17694996
131PLK40.17655478
132AKT10.17482680
133PTK60.17324720
134PAK20.16553186
135ROCK10.15101954
136PRKCQ0.14457728
137PRKCI0.11577548
138RPS6KC10.11399625
139RPS6KL10.11399625
140LYN0.11057236
141BTK0.10434967
142TYK20.09883102
143MAPK10.09776668
144CCNB10.09699601

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.11234018
2Viral carcinogenesis_Homo sapiens_hsa052033.28922854
3DNA replication_Homo sapiens_hsa030303.09237698
4Mismatch repair_Homo sapiens_hsa034302.88180528
5One carbon pool by folate_Homo sapiens_hsa006702.10551832
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05051017
7* Systemic lupus erythematosus_Homo sapiens_hsa0532210.8641311
8Cell cycle_Homo sapiens_hsa041101.99965634
9* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.82189783
10Ribosome_Homo sapiens_hsa030101.81891266
11Non-homologous end-joining_Homo sapiens_hsa034501.80003199
12RNA transport_Homo sapiens_hsa030131.76486261
13Homologous recombination_Homo sapiens_hsa034401.68324638
14Nucleotide excision repair_Homo sapiens_hsa034201.68308666
15Base excision repair_Homo sapiens_hsa034101.66902265
16Spliceosome_Homo sapiens_hsa030401.65428558
17Fanconi anemia pathway_Homo sapiens_hsa034601.64737225
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63237825
19p53 signaling pathway_Homo sapiens_hsa041151.22656581
20mRNA surveillance pathway_Homo sapiens_hsa030151.04423539
21RNA polymerase_Homo sapiens_hsa030200.98948722
22Pyrimidine metabolism_Homo sapiens_hsa002400.97264282
23MicroRNAs in cancer_Homo sapiens_hsa052060.90061078
24Hedgehog signaling pathway_Homo sapiens_hsa043400.89304830
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86831568
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84096325
27RNA degradation_Homo sapiens_hsa030180.81264638
28Small cell lung cancer_Homo sapiens_hsa052220.77371608
29Selenocompound metabolism_Homo sapiens_hsa004500.72849858
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68981955
31Herpes simplex infection_Homo sapiens_hsa051680.67997345
32HTLV-I infection_Homo sapiens_hsa051660.67091414
33Chronic myeloid leukemia_Homo sapiens_hsa052200.66438652
34Epstein-Barr virus infection_Homo sapiens_hsa051690.66256332
35Tight junction_Homo sapiens_hsa045300.58244548
36Wnt signaling pathway_Homo sapiens_hsa043100.57852140
37Basal transcription factors_Homo sapiens_hsa030220.57567904
38Oocyte meiosis_Homo sapiens_hsa041140.56805864
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54991880
40Non-small cell lung cancer_Homo sapiens_hsa052230.54961436
41Colorectal cancer_Homo sapiens_hsa052100.52610532
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52395935
43Antigen processing and presentation_Homo sapiens_hsa046120.51252235
44mTOR signaling pathway_Homo sapiens_hsa041500.50161894
45Apoptosis_Homo sapiens_hsa042100.49433427
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.47824030
47Central carbon metabolism in cancer_Homo sapiens_hsa052300.47728753
48Sulfur metabolism_Homo sapiens_hsa009200.47190015
49Lysine degradation_Homo sapiens_hsa003100.45912204
50Bladder cancer_Homo sapiens_hsa052190.45662697
51Steroid biosynthesis_Homo sapiens_hsa001000.43530989
52Thyroid cancer_Homo sapiens_hsa052160.43172760
53Hepatitis B_Homo sapiens_hsa051610.42810958
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40091429
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39653120
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39498746
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39294655
58B cell receptor signaling pathway_Homo sapiens_hsa046620.39104864
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.38883087
60Taste transduction_Homo sapiens_hsa047420.38825108
61Purine metabolism_Homo sapiens_hsa002300.37868396
62Biosynthesis of amino acids_Homo sapiens_hsa012300.36023894
63Measles_Homo sapiens_hsa051620.35070327
64Pentose phosphate pathway_Homo sapiens_hsa000300.34753401
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34154329
66Vitamin digestion and absorption_Homo sapiens_hsa049770.33203442
67Pancreatic cancer_Homo sapiens_hsa052120.32451759
68Primary immunodeficiency_Homo sapiens_hsa053400.30921911
69Notch signaling pathway_Homo sapiens_hsa043300.29570464
70ErbB signaling pathway_Homo sapiens_hsa040120.29385996
71Proteasome_Homo sapiens_hsa030500.29215362
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29164489
73FoxO signaling pathway_Homo sapiens_hsa040680.28198685
74TGF-beta signaling pathway_Homo sapiens_hsa043500.26816935
75Fatty acid biosynthesis_Homo sapiens_hsa000610.25858082
76Prostate cancer_Homo sapiens_hsa052150.25607313
77Melanoma_Homo sapiens_hsa052180.25598298
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25131869
79Renin-angiotensin system_Homo sapiens_hsa046140.24520033
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24396169
81Pathways in cancer_Homo sapiens_hsa052000.23402686
82Legionellosis_Homo sapiens_hsa051340.23156529
83Glioma_Homo sapiens_hsa052140.22525488
84HIF-1 signaling pathway_Homo sapiens_hsa040660.22400935
85Propanoate metabolism_Homo sapiens_hsa006400.21944044
86Hematopoietic cell lineage_Homo sapiens_hsa046400.21928362
87Basal cell carcinoma_Homo sapiens_hsa052170.21914403
88Melanogenesis_Homo sapiens_hsa049160.21293928
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21045932
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20781286
91Hippo signaling pathway_Homo sapiens_hsa043900.20714129
92Proteoglycans in cancer_Homo sapiens_hsa052050.20663022
93Pyruvate metabolism_Homo sapiens_hsa006200.20582977
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20398341
95Prolactin signaling pathway_Homo sapiens_hsa049170.20379216
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20049353
97Sulfur relay system_Homo sapiens_hsa041220.19908138
98Influenza A_Homo sapiens_hsa051640.19708632
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19622989
100Endometrial cancer_Homo sapiens_hsa052130.19536437
101Acute myeloid leukemia_Homo sapiens_hsa052210.19213278
102Type II diabetes mellitus_Homo sapiens_hsa049300.18464436
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.18388695
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18365797
105Axon guidance_Homo sapiens_hsa043600.18154067
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.16986640
107Viral myocarditis_Homo sapiens_hsa054160.16936974
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15948054
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15388871
110Dorso-ventral axis formation_Homo sapiens_hsa043200.14927397
111Nicotine addiction_Homo sapiens_hsa050330.14498342
112Toxoplasmosis_Homo sapiens_hsa051450.14430559
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14408109
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.13772643
115Adherens junction_Homo sapiens_hsa045200.12874258
116Cholinergic synapse_Homo sapiens_hsa047250.12788753
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.12417067
118Rap1 signaling pathway_Homo sapiens_hsa040150.12339800
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.12206785
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.12015663
121N-Glycan biosynthesis_Homo sapiens_hsa005100.11669023
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.10961454
123Osteoclast differentiation_Homo sapiens_hsa043800.09854826
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09814206
125Platelet activation_Homo sapiens_hsa046110.09655227
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.09201263
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.09077519
128Tryptophan metabolism_Homo sapiens_hsa003800.08703249
129Leishmaniasis_Homo sapiens_hsa051400.08668514
130Insulin resistance_Homo sapiens_hsa049310.08461541
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.08212641
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08034757
133Inositol phosphate metabolism_Homo sapiens_hsa005620.07594050
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.06994502
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.06990657
136AMPK signaling pathway_Homo sapiens_hsa041520.06743795
137Nitrogen metabolism_Homo sapiens_hsa009100.05780725
138MAPK signaling pathway_Homo sapiens_hsa040100.05647978
139Maturity onset diabetes of the young_Homo sapiens_hsa049500.05374895
140Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.05112286
141Estrogen signaling pathway_Homo sapiens_hsa049150.04052399
142RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.02925484
143Protein digestion and absorption_Homo sapiens_hsa049740.02474564
144Gap junction_Homo sapiens_hsa045400.01773083

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