HIST1H3J

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome assembly (GO:0006335)9.31724245
2DNA replication-dependent nucleosome organization (GO:0034723)9.31724245
3mucosal immune response (GO:0002385)9.03545468
4antibacterial humoral response (GO:0019731)8.72780790
5organ or tissue specific immune response (GO:0002251)8.16336181
6nucleosome assembly (GO:0006334)8.13759510
7antimicrobial humoral response (GO:0019730)7.99095383
8chromatin assembly (GO:0031497)7.41227108
9protein-DNA complex assembly (GO:0065004)7.02675065
10nucleosome organization (GO:0034728)6.76187898
11protein-DNA complex subunit organization (GO:0071824)6.01134423
12regulation of histone H3-K9 methylation (GO:0051570)5.94958343
13chromatin assembly or disassembly (GO:0006333)5.49680843
14negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.98756380
15DNA strand elongation involved in DNA replication (GO:0006271)4.67027209
16nuclear pore complex assembly (GO:0051292)4.63436965
17DNA unwinding involved in DNA replication (GO:0006268)4.52819510
18DNA strand elongation (GO:0022616)4.50425234
19CENP-A containing nucleosome assembly (GO:0034080)4.44963514
20protein localization to chromosome, centromeric region (GO:0071459)4.41827455
21chromatin remodeling at centromere (GO:0031055)4.33401711
22nuclear pore organization (GO:0006999)4.12481655
23telomere maintenance via semi-conservative replication (GO:0032201)4.10691089
24immunoglobulin mediated immune response (GO:0016064)4.01835056
25mitotic sister chromatid segregation (GO:0000070)3.93972417
26mitotic chromosome condensation (GO:0007076)3.83885846
27DNA replication initiation (GO:0006270)3.77209303
28B cell mediated immunity (GO:0019724)3.76116757
29B cell proliferation (GO:0042100)3.75915715
30B cell receptor signaling pathway (GO:0050853)3.74625730
31viral mRNA export from host cell nucleus (GO:0046784)3.74140645
32sister chromatid segregation (GO:0000819)3.70324506
33defense response to Gram-positive bacterium (GO:0050830)3.69644412
34negative regulation of B cell apoptotic process (GO:0002903)3.66699977
35positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.60919496
36regulation of megakaryocyte differentiation (GO:0045652)3.57702569
37telomere maintenance via recombination (GO:0000722)3.56650757
38protein localization to kinetochore (GO:0034501)3.43065075
39pore complex assembly (GO:0046931)3.42917050
40mitotic recombination (GO:0006312)3.40099557
41somatic hypermutation of immunoglobulin genes (GO:0016446)3.34072409
42somatic diversification of immune receptors via somatic mutation (GO:0002566)3.34072409
43T-helper 1 type immune response (GO:0042088)3.29701544
44histone exchange (GO:0043486)3.27381075
45V(D)J recombination (GO:0033151)3.24402591
46tongue development (GO:0043586)3.23050024
47DNA replication-independent nucleosome assembly (GO:0006336)3.22676967
48DNA replication-independent nucleosome organization (GO:0034724)3.22676967
49peptidyl-arginine omega-N-methylation (GO:0035247)3.18599915
50mitotic nuclear envelope disassembly (GO:0007077)3.12963546
51telomere maintenance (GO:0000723)3.07938750
52telomere organization (GO:0032200)3.07069361
53ATP-dependent chromatin remodeling (GO:0043044)3.06346519
54regulation of B cell receptor signaling pathway (GO:0050855)3.05154532
55telomere maintenance via telomere lengthening (GO:0010833)3.02992009
56positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.02855886
57regulation of B cell apoptotic process (GO:0002902)3.01105804
58T cell lineage commitment (GO:0002360)3.00481189
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.00231266
60mitotic metaphase plate congression (GO:0007080)2.92787090
61nucleotide-excision repair, DNA gap filling (GO:0006297)2.92385483
62somatic cell DNA recombination (GO:0016444)2.91839846
63somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.91839846
64membrane disassembly (GO:0030397)2.90035806
65nuclear envelope disassembly (GO:0051081)2.90035806
66establishment of viral latency (GO:0019043)2.84370320
67antigen processing and presentation of endogenous antigen (GO:0019883)2.83639530
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.82572704
69kinetochore organization (GO:0051383)2.82006602
70positive regulation of alpha-beta T cell proliferation (GO:0046641)2.78778155
71deoxyribonucleotide biosynthetic process (GO:0009263)2.77446367
72B cell homeostasis (GO:0001782)2.76663663
73regulation of gene silencing (GO:0060968)2.75637851
74DNA ligation (GO:0006266)2.75380891
75T cell migration (GO:0072678)2.73988430
76replicative senescence (GO:0090399)2.73335461
77negative regulation of chromosome segregation (GO:0051985)2.72179549
78regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.71693576
79somatic diversification of immune receptors (GO:0002200)2.71680340
80antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.71568223
81negative regulation of B cell proliferation (GO:0030889)2.69672709
82deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.69496065
83double-strand break repair via nonhomologous end joining (GO:0006303)2.68755714
84non-recombinational repair (GO:0000726)2.68755714
85regulation of chromosome segregation (GO:0051983)2.68720300
86DNA duplex unwinding (GO:0032508)2.68374740
87maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.64599808
88positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.63225359
89somatic recombination of immunoglobulin gene segments (GO:0016447)2.63003428
90regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.62253519
91regulation of mitotic metaphase/anaphase transition (GO:0030071)2.62253519
92histone arginine methylation (GO:0034969)2.60621727
93negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.59833030
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.59833030
95negative regulation of mitotic sister chromatid segregation (GO:0033048)2.59833030
96negative regulation of mitotic sister chromatid separation (GO:2000816)2.59833030
97negative regulation of sister chromatid segregation (GO:0033046)2.59833030
98protein localization to chromosome (GO:0034502)2.59118432
99humoral immune response (GO:0006959)2.58628637
100innate immune response in mucosa (GO:0002227)10.9109070

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.62566665
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.13555858
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.53506480
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.63961833
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.11141229
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.96641367
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.76327215
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.74973209
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60296232
10* SOX2_16153702_ChIP-ChIP_HESCs_Human2.53681889
11MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.26660440
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.24795454
13* POU5F1_16153702_ChIP-ChIP_HESCs_Human2.19406521
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.16000306
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse16.0634499
16HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.97383670
17RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.96647118
18CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.85246828
19IRF1_19129219_ChIP-ChIP_H3396_Human1.82736765
20NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75072585
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.74371478
22ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73476241
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70531949
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69411176
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.65379297
26MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63534434
27HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59254829
28ERG_20887958_ChIP-Seq_HPC-7_Mouse1.55205123
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.50908493
30MYC_22102868_ChIP-Seq_BL_Human1.50425649
31VDR_23849224_ChIP-Seq_CD4+_Human1.42358962
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.40766510
33SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.40112492
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37132155
35* NANOG_16153702_ChIP-ChIP_HESCs_Human1.30725154
36KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26862392
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.26454505
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23594040
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21213504
40CIITA_25753668_ChIP-Seq_RAJI_Human1.20771872
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20752296
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19650886
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18858492
44AR_21909140_ChIP-Seq_LNCAP_Human1.18607139
45VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16023062
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15548407
47GATA1_22025678_ChIP-Seq_K562_Human1.15172674
48SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13880850
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12917237
50ELK1_19687146_ChIP-ChIP_HELA_Human1.12141582
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08053299
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07901836
53SOX2_18692474_ChIP-Seq_MESCs_Mouse1.07416018
54ETS1_22383799_ChIP-Seq_G1ME_Mouse1.04255830
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03509471
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03360396
57VDR_21846776_ChIP-Seq_THP-1_Human1.03192893
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02208999
59MAF_26560356_Chip-Seq_TH1_Human1.01195312
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00260201
61ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99739647
62NOTCH1_21737748_ChIP-Seq_TLL_Human0.98475647
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97288466
64FOXP3_21729870_ChIP-Seq_TREG_Human0.96860102
65DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95960291
66MYC_18940864_ChIP-ChIP_HL60_Human0.95452134
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95173173
68PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93781930
69BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92344829
70EST1_17652178_ChIP-ChIP_JURKAT_Human0.89227897
71EGR1_19374776_ChIP-ChIP_THP-1_Human0.88403398
72MYC_19079543_ChIP-ChIP_MESCs_Mouse0.86506673
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.85672609
74CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84577776
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84218236
76XRN2_22483619_ChIP-Seq_HELA_Human0.84217574
77ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83856888
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82501536
79PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.81031731
80ETS1_20019798_ChIP-Seq_JURKAT_Human0.80465682
81MYB_26560356_Chip-Seq_TH1_Human0.79825048
82DCP1A_22483619_ChIP-Seq_HELA_Human0.77878327
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.75930516
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.74434276
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.72918226
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.72739538
87* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.70144811
88PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.69641281
89MYB_26560356_Chip-Seq_TH2_Human0.68967558
90ZFX_18555785_ChIP-Seq_MESCs_Mouse0.67560731
91TP63_17297297_ChIP-ChIP_HaCaT_Human0.65139373
92TCF3_18692474_ChIP-Seq_MESCs_Mouse0.64267065
93RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.63059540
94UTX_26944678_Chip-Seq_JUKART_Human0.62376013
95MYCN_18555785_ChIP-Seq_MESCs_Mouse0.61355206
96YY1_21170310_ChIP-Seq_MESCs_Mouse0.60601780
97GABP_17652178_ChIP-ChIP_JURKAT_Human0.60530380
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.59882248
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.56958466
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.55703270

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.16787994
2MP0000685_abnormal_immune_system4.18291951
3MP0003111_abnormal_nucleus_morphology3.97283075
4MP0005645_abnormal_hypothalamus_physiol3.93760976
5MP0008057_abnormal_DNA_replication3.91193854
6MP0003693_abnormal_embryo_hatching3.77448807
7MP0003077_abnormal_cell_cycle3.64593018
8MP0005671_abnormal_response_to3.31230787
9MP0004957_abnormal_blastocyst_morpholog3.05398770
10MP0001835_abnormal_antigen_presentation2.99911160
11MP0003763_abnormal_thymus_physiology2.83626221
12MP0001800_abnormal_humoral_immune2.73514155
13MP0005387_immune_system_phenotype2.47358833
14MP0001790_abnormal_immune_system2.47358833
15MP0002166_altered_tumor_susceptibility2.34793256
16MP0008058_abnormal_DNA_repair2.33366010
17MP0009697_abnormal_copulation2.30355972
18MP0002396_abnormal_hematopoietic_system2.21080501
19MP0002398_abnormal_bone_marrow2.11653591
20MP0005000_abnormal_immune_tolerance2.00828000
21MP0010352_gastrointestinal_tract_polyps1.98591647
22MP0002006_tumorigenesis1.94594210
23MP0000350_abnormal_cell_proliferation1.89363960
24MP0003183_abnormal_peptide_metabolism1.87836783
25MP0008932_abnormal_embryonic_tissue1.84189511
26MP0002452_abnormal_antigen_presenting1.81754481
27MP0002009_preneoplasia1.77435793
28MP0008007_abnormal_cellular_replicative1.75366129
29MP0002138_abnormal_hepatobiliary_system1.74276096
30MP0002722_abnormal_immune_system1.70056776
31MP0000689_abnormal_spleen_morphology1.68168656
32MP0002723_abnormal_immune_serum1.67751166
33MP0002420_abnormal_adaptive_immunity1.65953649
34MP0000703_abnormal_thymus_morphology1.61248186
35MP0001819_abnormal_immune_cell1.59641748
36MP0000716_abnormal_immune_system1.57980585
37MP0002019_abnormal_tumor_incidence1.57870319
38MP0010307_abnormal_tumor_latency1.49515746
39MP0002429_abnormal_blood_cell1.48065244
40MP0000313_abnormal_cell_death1.47338722
41MP0009046_muscle_twitch1.46059238
42MP0000490_abnormal_crypts_of1.41378680
43MP0002163_abnormal_gland_morphology1.40755249
44MP0001727_abnormal_embryo_implantation1.39984413
45MP0001730_embryonic_growth_arrest1.34974171
46MP0010234_abnormal_vibrissa_follicle1.27117309
47MP0005310_abnormal_salivary_gland1.24457886
48MP0006035_abnormal_mitochondrial_morpho1.21988685
49MP0003786_premature_aging1.18301807
50MP0003941_abnormal_skin_development1.14573383
51MP0000358_abnormal_cell_content/1.09701791
52MP0005025_abnormal_response_to1.06309404
53MP0010155_abnormal_intestine_physiology1.03725831
54MP0001661_extended_life_span1.03011648
55MP0000372_irregular_coat_pigmentation1.02326705
56MP0005220_abnormal_exocrine_pancreas1.01355343
57MP0003718_maternal_effect1.01067740
58MP0005084_abnormal_gallbladder_morpholo1.00734666
59MP0002080_prenatal_lethality1.00393040
60MP0005380_embryogenesis_phenotype0.95396113
61MP0001672_abnormal_embryogenesis/_devel0.95396113
62MP0005464_abnormal_platelet_physiology0.94472592
63MP0004808_abnormal_hematopoietic_stem0.92951389
64MP0005623_abnormal_meninges_morphology0.92262556
65MP0001845_abnormal_inflammatory_respons0.91276237
66MP0002086_abnormal_extraembryonic_tissu0.91044553
67MP0001697_abnormal_embryo_size0.87927134
68MP0003300_gastrointestinal_ulcer0.87528209
69MP0003984_embryonic_growth_retardation0.84186505
70MP0009785_altered_susceptibility_to0.82031327
71MP0004947_skin_inflammation0.81264103
72MP0002148_abnormal_hypersensitivity_rea0.80122645
73MP0002088_abnormal_embryonic_growth/wei0.79786530
74MP0003303_peritoneal_inflammation0.77130653
75MP0005083_abnormal_biliary_tract0.74612204
76MP0002928_abnormal_bile_duct0.72258623
77MP0005384_cellular_phenotype0.71778347
78MP0002085_abnormal_embryonic_tissue0.69395451
79MP0002139_abnormal_hepatobiliary_system0.68281881
80MP0005621_abnormal_cell_physiology0.65837946
81MP0002210_abnormal_sex_determination0.65728842
82MP0004381_abnormal_hair_follicle0.65668122
83MP0009333_abnormal_splenocyte_physiolog0.65041197
84MP0003221_abnormal_cardiomyocyte_apopto0.64557228
85MP0002084_abnormal_developmental_patter0.62999493
86MP0001348_abnormal_lacrimal_gland0.62623649
87MP0004197_abnormal_fetal_growth/weight/0.61672999
88MP0002405_respiratory_system_inflammati0.60175781
89MP0000371_diluted_coat_color0.59306471
90MP0002083_premature_death0.57301469
91MP0001191_abnormal_skin_condition0.55382732
92MP0005171_absent_coat_pigmentation0.54617868
93MP0002877_abnormal_melanocyte_morpholog0.53292073
94MP0001929_abnormal_gametogenesis0.53239467
95MP0003699_abnormal_female_reproductive0.52386915
96MP0005076_abnormal_cell_differentiation0.52245300
97MP0001529_abnormal_vocalization0.51338155
98MP0001919_abnormal_reproductive_system0.50589022
99MP0000465_gastrointestinal_hemorrhage0.50588621
100MP0001145_abnormal_male_reproductive0.48998836

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)6.88626631
2IgA deficiency (HP:0002720)6.86839497
3IgM deficiency (HP:0002850)6.66087706
4Recurrent sinusitis (HP:0011108)5.21544811
5Agammaglobulinemia (HP:0004432)4.95534129
6Recurrent bronchitis (HP:0002837)4.81212979
7Lymphopenia (HP:0001888)4.48295132
8Chromosomal breakage induced by crosslinking agents (HP:0003221)4.30935924
9Abnormality of cells of the lymphoid lineage (HP:0012140)4.27203658
10Dry hair (HP:0011359)4.14776288
11Cellulitis (HP:0100658)3.87285941
12Chromsome breakage (HP:0040012)3.84641622
13IgG deficiency (HP:0004315)3.71786937
14Squamous cell carcinoma (HP:0002860)3.64885828
15B lymphocytopenia (HP:0010976)3.60703534
16Basal cell carcinoma (HP:0002671)3.55243099
17Meningitis (HP:0001287)3.47233719
18Onycholysis (HP:0001806)3.28646174
19Colitis (HP:0002583)3.28559455
20Emphysema (HP:0002097)3.27671729
21Lymphoma (HP:0002665)3.23197670
22Abnormality of B cell number (HP:0010975)3.21799567
23Medulloblastoma (HP:0002885)3.10266838
24Ridged nail (HP:0001807)3.09959574
25Recurrent pneumonia (HP:0006532)3.05406664
26Chronic diarrhea (HP:0002028)3.04049512
27Recurrent lower respiratory tract infections (HP:0002783)2.92242366
28Oral leukoplakia (HP:0002745)2.88016718
29Vasculitis (HP:0002633)2.85692993
30Abnormality of the prostate (HP:0008775)2.84344873
31Leukopenia (HP:0001882)2.82721743
32Panhypogammaglobulinemia (HP:0003139)2.82612624
33Abnormality of chromosome stability (HP:0003220)2.76728895
34Abnormality of T cell physiology (HP:0011840)2.71191320
35Prostate neoplasm (HP:0100787)2.70881823
36Recurrent viral infections (HP:0004429)2.70795864
37Abnormality of the preputium (HP:0100587)2.67894438
38Urticaria (HP:0001025)2.64528935
39Osteomyelitis (HP:0002754)2.62770708
40Bronchitis (HP:0012387)2.60204409
41Erythema (HP:0010783)2.53375248
42Mediastinal lymphadenopathy (HP:0100721)2.43590191
43Restrictive lung disease (HP:0002091)2.43117033
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.40798462
45Meckel diverticulum (HP:0002245)2.30869281
46Conical tooth (HP:0000698)2.28327582
47Abnormality of the carotid arteries (HP:0005344)2.27683165
48Lipid accumulation in hepatocytes (HP:0006561)2.27461168
49Autoimmune hemolytic anemia (HP:0001890)2.25964433
50Abnormality of the ileum (HP:0001549)2.23673495
51Microvesicular hepatic steatosis (HP:0001414)2.18800388
52Skin rash (HP:0000988)2.17369614
53Cholecystitis (HP:0001082)2.16451222
54Abnormal gallbladder physiology (HP:0012438)2.16451222
55Combined immunodeficiency (HP:0005387)2.13609288
56Recurrent otitis media (HP:0000403)2.13516830
57Carpal bone hypoplasia (HP:0001498)2.12703163
58Verrucae (HP:0200043)2.11864971
59Papilloma (HP:0012740)2.11864971
60Increased IgM level (HP:0003496)2.10807810
61Nephroblastoma (Wilms tumor) (HP:0002667)2.10780283
62Orthostatic hypotension (HP:0001278)2.10559102
63Sepsis (HP:0100806)2.08381745
64Inflammation of the large intestine (HP:0002037)2.07617932
65Eczematoid dermatitis (HP:0000976)2.05056588
66Clubbing of toes (HP:0100760)1.98000792
67Gastrointestinal inflammation (HP:0004386)1.97749991
68Abnormality of incisor morphology (HP:0011063)1.97086659
69Abnormality of male internal genitalia (HP:0000022)1.96301121
70Embryonal renal neoplasm (HP:0011794)1.94321026
71Abnormality of T cells (HP:0002843)1.94043160
72Recurrent bacterial skin infections (HP:0005406)1.93893055
73Severe combined immunodeficiency (HP:0004430)1.92468765
74Hepatitis (HP:0012115)1.91521279
75Small intestinal stenosis (HP:0012848)1.91359684
76Duodenal stenosis (HP:0100867)1.91359684
77Sparse scalp hair (HP:0002209)1.89654351
78Increased hepatocellular lipid droplets (HP:0006565)1.88757022
79Abnormal delayed hypersensitivity skin test (HP:0002963)1.88180026
80Thyroiditis (HP:0100646)1.83878514
81Colon cancer (HP:0003003)1.79813479
82Premature loss of primary teeth (HP:0006323)1.76255789
83Viral hepatitis (HP:0006562)1.75165167
84Neutropenia (HP:0001875)1.72922925
85Neoplasm of striated muscle (HP:0009728)1.72921220
86Spontaneous hematomas (HP:0007420)1.72782140
87Hypoplasia of the thymus (HP:0000778)1.72212496
88Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70685582
89Abnormality of DNA repair (HP:0003254)1.70676968
90Short 4th metacarpal (HP:0010044)1.69708972
91Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.69708972
92Rough bone trabeculation (HP:0100670)1.69182796
93Ovarian neoplasm (HP:0100615)1.69009524
94Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.67191770
95Teleangiectasia of the skin (HP:0100585)1.66410583
96Cleft eyelid (HP:0000625)1.64375611
97Acute lymphatic leukemia (HP:0006721)1.63859725
98Hypoplasia of the pons (HP:0012110)1.63396575
99Myelodysplasia (HP:0002863)1.62748274
100Progressive muscle weakness (HP:0003323)1.60982231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK9.74546340
2TLK19.22247852
3* VRK13.77214343
4RPS6KA53.42508510
5SMG12.34466267
6STK42.20465179
7BUB12.06644929
8TAF11.98583545
9CDC71.96687221
10* AURKA1.67861658
11* DAPK31.57276910
12VRK21.50135081
13CHEK21.38550183
14PKN11.28404753
15PIM11.26208066
16NEK11.19623065
17* AURKB1.15081363
18BLK1.10066073
19TTK1.07295169
20MAP2K71.06423870
21IRAK41.01728447
22BCKDK1.01148302
23MAP3K80.98686063
24SCYL20.94738075
25MAP3K100.93478644
26EIF2AK30.92402589
27SRPK10.91450539
28MAP4K10.86499141
29PLK40.83036164
30EEF2K0.82142625
31SYK0.82108688
32CCNB10.80486071
33BTK0.80259876
34NEK90.77229764
35MAP3K40.76801851
36RPS6KB20.74630156
37MST40.72734090
38BRAF0.70029164
39ATR0.69287845
40AKT20.66214394
41PRKCQ0.62718051
42WEE10.61342302
43CDK120.58133931
44PLK10.55595439
45BRSK20.55435277
46NME20.53238667
47CDK70.52875022
48PBK0.52584618
49MELK0.46553024
50LYN0.45654501
51CHEK10.43754048
52PRKAA10.43622206
53RIPK40.43238442
54MAPK110.42821924
55MAPKAPK50.40804753
56PLK30.38951730
57CDK90.38425771
58TSSK60.37278326
59ARAF0.37123719
60MAP3K90.37111929
61ICK0.36779300
62CSF1R0.36365354
63STK160.35319896
64NUAK10.33748810
65EIF2AK20.32810260
66CSNK1G30.32193169
67CDK40.32005296
68MAP3K140.31807832
69PAK10.31625253
70NLK0.30914047
71PIM20.30457850
72JAK20.29102263
73CDK20.28678919
74IKBKB0.28230248
75STK100.27707261
76ATM0.27578098
77CSNK1A1L0.26450006
78TBK10.26225761
79CSNK1G10.26098633
80NEK20.25949351
81KDR0.24305693
82PRKCD0.23556800
83IKBKE0.22332974
84BRSK10.19876765
85TESK20.18494710
86MAP2K40.18186275
87ALK0.17147458
88CDK80.16736886
89CDK10.16627811
90FGFR40.16256953
91CAMK40.15130610
92CDK150.13498066
93CSNK2A20.12737271
94CDK190.12158700
95CDK60.11803104
96PRPF4B0.11490773
97MKNK20.11367609
98DAPK10.11077405
99CDK11A0.10438716
100MAP3K130.10244533

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050347.69447190
2Viral carcinogenesis_Homo sapiens_hsa052033.52375713
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.29752738
4DNA replication_Homo sapiens_hsa030302.28168707
5Primary immunodeficiency_Homo sapiens_hsa053402.13364230
6* Systemic lupus erythematosus_Homo sapiens_hsa0532211.1452980
7Allograft rejection_Homo sapiens_hsa053301.89885292
8Asthma_Homo sapiens_hsa053101.83737702
9Autoimmune thyroid disease_Homo sapiens_hsa053201.76998924
10* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.72197620
11Mismatch repair_Homo sapiens_hsa034301.71339495
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.55159814
13Graft-versus-host disease_Homo sapiens_hsa053321.53805300
14Type I diabetes mellitus_Homo sapiens_hsa049401.36387324
15Viral myocarditis_Homo sapiens_hsa054161.19661092
16Base excision repair_Homo sapiens_hsa034101.10347466
17Cell cycle_Homo sapiens_hsa041101.08977520
18Homologous recombination_Homo sapiens_hsa034401.05164830
19B cell receptor signaling pathway_Homo sapiens_hsa046621.00822123
20Non-homologous end-joining_Homo sapiens_hsa034500.98762797
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97451793
22Nucleotide excision repair_Homo sapiens_hsa034200.96546879
23Antigen processing and presentation_Homo sapiens_hsa046120.94321025
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87982845
25Fanconi anemia pathway_Homo sapiens_hsa034600.87611193
26Spliceosome_Homo sapiens_hsa030400.79870156
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77687749
28Herpes simplex infection_Homo sapiens_hsa051680.73594805
29Leishmaniasis_Homo sapiens_hsa051400.72951500
30Epstein-Barr virus infection_Homo sapiens_hsa051690.72853577
31One carbon pool by folate_Homo sapiens_hsa006700.68855798
32Pentose phosphate pathway_Homo sapiens_hsa000300.68775696
33p53 signaling pathway_Homo sapiens_hsa041150.66368066
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60825997
35Pyrimidine metabolism_Homo sapiens_hsa002400.60141187
36Biosynthesis of amino acids_Homo sapiens_hsa012300.59418528
37Proteasome_Homo sapiens_hsa030500.59162626
38HTLV-I infection_Homo sapiens_hsa051660.54238044
39Sulfur relay system_Homo sapiens_hsa041220.51929704
40Ribosome_Homo sapiens_hsa030100.50047218
41RNA transport_Homo sapiens_hsa030130.48451838
42Staphylococcus aureus infection_Homo sapiens_hsa051500.44013166
43Influenza A_Homo sapiens_hsa051640.43826399
44Hematopoietic cell lineage_Homo sapiens_hsa046400.42474816
45Carbon metabolism_Homo sapiens_hsa012000.41059863
46Fructose and mannose metabolism_Homo sapiens_hsa000510.35527216
47RNA polymerase_Homo sapiens_hsa030200.33376154
48NF-kappa B signaling pathway_Homo sapiens_hsa040640.31331816
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30915529
50Selenocompound metabolism_Homo sapiens_hsa004500.30182191
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.29711461
52RNA degradation_Homo sapiens_hsa030180.29660933
53Apoptosis_Homo sapiens_hsa042100.29485468
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28212289
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27169013
56Measles_Homo sapiens_hsa051620.27105303
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.26576183
58Hepatitis B_Homo sapiens_hsa051610.25890541
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24832038
60Purine metabolism_Homo sapiens_hsa002300.23867205
61Phenylalanine metabolism_Homo sapiens_hsa003600.23124834
62mRNA surveillance pathway_Homo sapiens_hsa030150.22756693
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22438302
64Rheumatoid arthritis_Homo sapiens_hsa053230.21755860
65Toxoplasmosis_Homo sapiens_hsa051450.21705575
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.19952661
67Pancreatic cancer_Homo sapiens_hsa052120.18429025
68Thyroid cancer_Homo sapiens_hsa052160.18178836
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.17786706
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17366954
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17097128
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.15263569
73Tuberculosis_Homo sapiens_hsa051520.15211983
74Colorectal cancer_Homo sapiens_hsa052100.14967283
75Parkinsons disease_Homo sapiens_hsa050120.13033136
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12168023
77Oocyte meiosis_Homo sapiens_hsa041140.12159091
78Pyruvate metabolism_Homo sapiens_hsa006200.11397685
79Galactose metabolism_Homo sapiens_hsa000520.11318290
80Non-small cell lung cancer_Homo sapiens_hsa052230.10265362
81Basal cell carcinoma_Homo sapiens_hsa052170.10223500
82Basal transcription factors_Homo sapiens_hsa030220.09816777
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09803731
84Huntingtons disease_Homo sapiens_hsa050160.09554191
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.09093102
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.08272400
87Phagosome_Homo sapiens_hsa041450.07760989
88Shigellosis_Homo sapiens_hsa051310.07098380
89Vitamin B6 metabolism_Homo sapiens_hsa007500.06748648
90MicroRNAs in cancer_Homo sapiens_hsa052060.06653452
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.06609608
92Oxidative phosphorylation_Homo sapiens_hsa001900.06315549
93Bladder cancer_Homo sapiens_hsa052190.04700861
94Chronic myeloid leukemia_Homo sapiens_hsa052200.04689797
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.02879401
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.02156303
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.01219688
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.00890591
99T cell receptor signaling pathway_Homo sapiens_hsa046600.00529553
100Glutathione metabolism_Homo sapiens_hsa004800.00176041

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