ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	6.09507817
2	viral transcription (GO:0019083)	5.90316824
3	translational termination (GO:0006415)	5.70538298
4	behavioral response to nicotine (GO:0035095)	5.53440407
5	ribosomal small subunit assembly (GO:0000028)	5.53395059
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.27836426
7	ATP synthesis coupled proton transport (GO:0015986)	5.27836426
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.95166167
9	cotranslational protein targeting to membrane (GO:0006613)	4.90103734
10	chaperone-mediated protein transport (GO:0072321)	4.88780943
11	protein targeting to ER (GO:0045047)	4.88385604
12	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.78713818
13	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.78713818
14	NADH dehydrogenase complex assembly (GO:0010257)	4.78713818
15	translational elongation (GO:0006414)	4.78006759
16	ribosomal small subunit biogenesis (GO:0042274)	4.74723861
17	protein complex biogenesis (GO:0070271)	4.71070742
18	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.70991407
19	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.63640552
20	protein localization to endoplasmic reticulum (GO:0070972)	4.60185396
21	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.52467516
22	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.44325372
23	cellular protein complex disassembly (GO:0043624)	4.44290348
24	viral life cycle (GO:0019058)	4.35283876
25	mitochondrial respiratory chain complex assembly (GO:0033108)	4.28131643
26	sequestering of actin monomers (GO:0042989)	4.24472086
27	pyrimidine nucleobase catabolic process (GO:0006208)	4.19178456
28	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.14084263
29	respiratory electron transport chain (GO:0022904)	4.03696323
30	electron transport chain (GO:0022900)	4.00106699
31	maturation of SSU-rRNA (GO:0030490)	3.88850079
32	protein complex disassembly (GO:0043241)	3.81465996
33	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.76513773
34	macromolecular complex disassembly (GO:0032984)	3.64812861
35	translational initiation (GO:0006413)	3.56780405
36	pyrimidine nucleotide catabolic process (GO:0006244)	3.45502809
37	cell proliferation in forebrain (GO:0021846)	3.44063718
38	epithelial cilium movement (GO:0003351)	3.41989226
39	protein localization to cilium (GO:0061512)	3.31188438
40	protein targeting to membrane (GO:0006612)	3.30025760
41	nucleobase catabolic process (GO:0046113)	3.28484549
42	negative regulation of response to food (GO:0032096)	3.28281097
43	negative regulation of appetite (GO:0032099)	3.28281097
44	water-soluble vitamin biosynthetic process (GO:0042364)	3.27625387
45	hydrogen ion transmembrane transport (GO:1902600)	3.20809919
46	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.19392020
47	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.19392020
48	translation (GO:0006412)	3.17211410
49	nonmotile primary cilium assembly (GO:0035058)	3.12907878
50	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.10507466
51	response to pheromone (GO:0019236)	3.10498844
52	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.09278589
53	substrate-independent telencephalic tangential migration (GO:0021826)	3.09278589
54	GTP biosynthetic process (GO:0006183)	3.08029532
55	DNA deamination (GO:0045006)	3.04383951
56	somite development (GO:0061053)	3.01409177
57	base-excision repair, AP site formation (GO:0006285)	2.99725135
58	spinal cord association neuron differentiation (GO:0021527)	2.99097373
59	intraciliary transport (GO:0042073)	2.97622055
60	ribosomal large subunit biogenesis (GO:0042273)	2.96177414
61	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.94651159
62	ATP biosynthetic process (GO:0006754)	2.90426409
63	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.89403472
64	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.88996002
65	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.86868652
66	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.86789115
67	proton transport (GO:0015992)	2.86162361
68	positive regulation of T cell apoptotic process (GO:0070234)	2.84494170
69	regulation of cilium movement (GO:0003352)	2.84364977
70	axonal fasciculation (GO:0007413)	2.82603444
71	hydrogen transport (GO:0006818)	2.81408129
72	platelet dense granule organization (GO:0060155)	2.81275898
73	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.80194082
74	cellular component biogenesis (GO:0044085)	2.78299524
75	short-term memory (GO:0007614)	2.75355647
76	neuron recognition (GO:0008038)	2.73765099
77	transmission of nerve impulse (GO:0019226)	2.73629023
78	protein polyglutamylation (GO:0018095)	2.72634489
79	positive regulation of mitochondrial fission (GO:0090141)	2.69501233
80	mRNA catabolic process (GO:0006402)	2.68539045
81	establishment of mitochondrion localization (GO:0051654)	2.67954581
82	neurofilament cytoskeleton organization (GO:0060052)	2.65465238
83	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.64541460
84	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.64316302
85	axoneme assembly (GO:0035082)	2.59044292
86	cilium movement (GO:0003341)	2.57317141
87	olfactory bulb development (GO:0021772)	2.52570652
88	retinal ganglion cell axon guidance (GO:0031290)	2.51999491
89	synaptic transmission, cholinergic (GO:0007271)	2.48832907
90	protein targeting to mitochondrion (GO:0006626)	2.47780801
91	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.47298420
92	establishment of protein localization to mitochondrion (GO:0072655)	2.46798640
93	UTP biosynthetic process (GO:0006228)	2.46446554
94	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.45142261
95	hypothalamus development (GO:0021854)	2.44632314
96	establishment of protein localization to membrane (GO:0090150)	2.43559361
97	protein targeting (GO:0006605)	2.41480525
98	protein peptidyl-prolyl isomerization (GO:0000413)	2.41309509
99	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.40740220
100	respiratory chain complex IV assembly (GO:0008535)	2.39824667

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.96949285
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.73212202
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.52352132
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.13094042
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.80579486
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.50312303
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.39785833
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.12461166
9	VDR_22108803_ChIP-Seq_LS180_Human	2.12375388
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.11249531
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.10033215
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.09115473
13	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.95170857
14	REST_21632747_ChIP-Seq_MESCs_Mouse	1.95148893
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.92814296
16	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.91706092
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.90793576
18	IRF1_19129219_ChIP-ChIP_H3396_Human	1.79465084
19	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.78854480
20	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.76170749
21	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.71737538
22	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.61632004
23	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.60225573
24	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.59823738
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.59429040
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.54974851
27	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.54167718
28	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.53070481
29	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.48374840
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.48003170
31	RNF2_27304074_Chip-Seq_NSC_Mouse	1.44130755
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.34892046
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.34400950
34	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.33867233
35	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.33756449
36	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.32261663
37	IGF1R_20145208_ChIP-Seq_DFB_Human	1.31954838
38	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.31480611
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30561260
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30258746
41	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.30161955
42	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.28439534
43	VDR_23849224_ChIP-Seq_CD4+_Human	1.27874003
44	ELK1_19687146_ChIP-ChIP_HELA_Human	1.23719640
45	FUS_26573619_Chip-Seq_HEK293_Human	1.22559704
46	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.20643886
47	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.19759784
48	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.18519104
49	NANOG_20526341_ChIP-Seq_ESCs_Human	1.18297093
50	MYC_19829295_ChIP-Seq_ESCs_Human	1.15374482
51	TTF2_22483619_ChIP-Seq_HELA_Human	1.13639294
52	GABP_19822575_ChIP-Seq_HepG2_Human	1.13594024
53	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.13073105
54	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.13038349
55	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.12649964
56	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.12536767
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.11959439
58	ERA_21632823_ChIP-Seq_H3396_Human	1.11638706
59	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.10487030
60	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.09709484
61	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.08854707
62	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.08746439
63	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08698988
64	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.07618805
65	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.07261986
66	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.07175370
67	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.06329111
68	NCOR_22424771_ChIP-Seq_293T_Human	1.04182283
69	TAF2_19829295_ChIP-Seq_ESCs_Human	1.04008495
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03245459
71	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.02895957
72	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.02505293
73	CTCF_27219007_Chip-Seq_Bcells_Human	1.01431019
74	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.99417445
75	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.98882848
76	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.97553977
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96943735
78	EWS_26573619_Chip-Seq_HEK293_Human	0.96195908
79	P300_19829295_ChIP-Seq_ESCs_Human	0.95573988
80	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.95164463
81	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.93367505
82	FOXP3_21729870_ChIP-Seq_TREG_Human	0.92945553
83	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.92780112
84	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.91653163
85	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.91653163
86	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.91640876
87	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.90657378
88	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.90492224
89	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.90472100
90	XRN2_22483619_ChIP-Seq_HELA_Human	0.89876404
91	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.89588511
92	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.89168828
93	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.89014316
94	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.88645840
95	P53_21459846_ChIP-Seq_SAOS-2_Human	0.88460143
96	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.87828482
97	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.87217803
98	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.87177721
99	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.87046798
100	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.86906181

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	5.08314216
2	MP0009379_abnormal_foot_pigmentation	3.72513013
3	MP0003123_paternal_imprinting	3.52038855
4	MP0003122_maternal_imprinting	3.48186713
5	MP0006292_abnormal_olfactory_placode	3.25095959
6	MP0003121_genomic_imprinting	3.04571212
7	MP0008877_abnormal_DNA_methylation	2.81006991
8	MP0006276_abnormal_autonomic_nervous	2.54727564
9	MP0001986_abnormal_taste_sensitivity	2.52524885
10	MP0008789_abnormal_olfactory_epithelium	2.51526749
11	MP0002653_abnormal_ependyma_morphology	2.40520797
12	MP0003880_abnormal_central_pattern	2.33122924
13	MP0005394_taste/olfaction_phenotype	2.28128681
14	MP0005499_abnormal_olfactory_system	2.28128681
15	MP0004142_abnormal_muscle_tone	2.10559264
16	MP0002102_abnormal_ear_morphology	1.97891783
17	MP0001529_abnormal_vocalization	1.94868164
18	MP0005646_abnormal_pituitary_gland	1.87135282
19	MP0000778_abnormal_nervous_system	1.84622498
20	MP0002272_abnormal_nervous_system	1.73926628
21	MP0005551_abnormal_eye_electrophysiolog	1.71708538
22	MP0005423_abnormal_somatic_nervous	1.71207425
23	MP0001968_abnormal_touch/_nociception	1.70806066
24	MP0001905_abnormal_dopamine_level	1.68118463
25	MP0009046_muscle_twitch	1.65858949
26	MP0005645_abnormal_hypothalamus_physiol	1.65365502
27	MP0001984_abnormal_olfaction	1.63191156
28	MP0001188_hyperpigmentation	1.60161025
29	MP0003315_abnormal_perineum_morphology	1.58073464
30	MP0002557_abnormal_social/conspecific_i	1.57063827
31	MP0005084_abnormal_gallbladder_morpholo	1.51038614
32	MP0001970_abnormal_pain_threshold	1.49766862
33	MP0009745_abnormal_behavioral_response	1.47654629
34	MP0004147_increased_porphyrin_level	1.45892974
35	MP0000049_abnormal_middle_ear	1.45584970
36	MP0004145_abnormal_muscle_electrophysio	1.43435867
37	MP0002733_abnormal_thermal_nociception	1.42193039
38	MP0001485_abnormal_pinna_reflex	1.41349632
39	MP0000631_abnormal_neuroendocrine_gland	1.39823105
40	MP0006072_abnormal_retinal_apoptosis	1.39139973
41	MP0002837_dystrophic_cardiac_calcinosis	1.39032335
42	MP0001919_abnormal_reproductive_system	1.35298265
43	MP0000955_abnormal_spinal_cord	1.33946884
44	MP0002572_abnormal_emotion/affect_behav	1.30567870
45	MP0002163_abnormal_gland_morphology	1.29113664
46	MP0003635_abnormal_synaptic_transmissio	1.27785044
47	MP0005389_reproductive_system_phenotype	1.27662791
48	MP0002876_abnormal_thyroid_physiology	1.26863793
49	MP0002736_abnormal_nociception_after	1.26700352
50	MP0003011_delayed_dark_adaptation	1.25381516
51	MP0002184_abnormal_innervation	1.24643301
52	MP0002063_abnormal_learning/memory/cond	1.23138323
53	MP0001440_abnormal_grooming_behavior	1.22815244
54	MP0000372_irregular_coat_pigmentation	1.21487188
55	MP0002160_abnormal_reproductive_system	1.20721248
56	MP0003646_muscle_fatigue	1.20224046
57	MP0001293_anophthalmia	1.14771565
58	MP0008875_abnormal_xenobiotic_pharmacok	1.13692000
59	MP0002638_abnormal_pupillary_reflex	1.12777701
60	MP0002752_abnormal_somatic_nervous	1.12595857
61	MP0008872_abnormal_physiological_respon	1.12099930
62	MP0002734_abnormal_mechanical_nocicepti	1.11699260
63	MP0004885_abnormal_endolymph	1.05867137
64	MP0002064_seizures	1.04853114
65	MP0002067_abnormal_sensory_capabilities	1.02890072
66	MP0005195_abnormal_posterior_eye	1.02279788
67	MP0002882_abnormal_neuron_morphology	1.02214044
68	MP0003890_abnormal_embryonic-extraembry	0.99590928
69	MP0005083_abnormal_biliary_tract	0.98292830
70	MP0004133_heterotaxia	0.98195317
71	MP0004924_abnormal_behavior	0.96641934
72	MP0005386_behavior/neurological_phenoty	0.96641934
73	MP0002735_abnormal_chemical_nociception	0.96096731
74	MP0004859_abnormal_synaptic_plasticity	0.95463531
75	MP0003879_abnormal_hair_cell	0.95339709
76	MP0002822_catalepsy	0.94167172
77	MP0008995_early_reproductive_senescence	0.92290542
78	MP0003186_abnormal_redox_activity	0.92172947
79	MP0002234_abnormal_pharynx_morphology	0.91201308
80	MP0001486_abnormal_startle_reflex	0.89823772
81	MP0005410_abnormal_fertilization	0.86489594
82	MP0009053_abnormal_anal_canal	0.86256432
83	MP0006035_abnormal_mitochondrial_morpho	0.83275235
84	MP0005253_abnormal_eye_physiology	0.82985167
85	MP0002152_abnormal_brain_morphology	0.82654024
86	MP0004742_abnormal_vestibular_system	0.81867362
87	MP0004811_abnormal_neuron_physiology	0.78762268
88	MP0000026_abnormal_inner_ear	0.77875627
89	MP0003283_abnormal_digestive_organ	0.77782160
90	MP0005377_hearing/vestibular/ear_phenot	0.76977694
91	MP0003878_abnormal_ear_physiology	0.76977694
92	MP0003136_yellow_coat_color	0.76360714
93	MP0001963_abnormal_hearing_physiology	0.74503241
94	MP0002938_white_spotting	0.73346602
95	MP0003567_abnormal_fetal_cardiomyocyte	0.72472087
96	MP0000230_abnormal_systemic_arterial	0.70855519
97	MP0002210_abnormal_sex_determination	0.70734575
98	MP0005379_endocrine/exocrine_gland_phen	0.69301390
99	MP0003942_abnormal_urinary_system	0.69124825
100	MP0001727_abnormal_embryo_implantation	0.67449796

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.61108255
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.19809819
3	Acute encephalopathy (HP:0006846)	4.07442668
4	3-Methylglutaconic aciduria (HP:0003535)	3.95528368
5	Mitochondrial inheritance (HP:0001427)	3.80056762
6	Abnormality of midbrain morphology (HP:0002418)	3.79385123
7	Molar tooth sign on MRI (HP:0002419)	3.79385123
8	Progressive macrocephaly (HP:0004481)	3.70816672
9	Pancreatic fibrosis (HP:0100732)	3.70018153
10	Reticulocytopenia (HP:0001896)	3.68880723
11	Abnormality of cells of the erythroid lineage (HP:0012130)	3.58297382
12	Pancreatic cysts (HP:0001737)	3.22157795
13	Hepatocellular necrosis (HP:0001404)	3.20940965
14	Myokymia (HP:0002411)	3.16494315
15	Agitation (HP:0000713)	3.13822314
16	Medial flaring of the eyebrow (HP:0010747)	3.07676085
17	Increased CSF lactate (HP:0002490)	3.07603010
18	True hermaphroditism (HP:0010459)	3.04654952
19	Abnormal number of erythroid precursors (HP:0012131)	3.03692727
20	Optic disc pallor (HP:0000543)	2.95380089
21	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.88745364
22	Gait imbalance (HP:0002141)	2.86961819
23	Cerebral edema (HP:0002181)	2.85236432
24	Polyphagia (HP:0002591)	2.77538454
25	Hyperthyroidism (HP:0000836)	2.75373866
26	Hepatic necrosis (HP:0002605)	2.74626950
27	Macrocytic anemia (HP:0001972)	2.70636644
28	Renal Fanconi syndrome (HP:0001994)	2.66325003
29	Progressive cerebellar ataxia (HP:0002073)	2.65755857
30	Nephronophthisis (HP:0000090)	2.63964473
31	Congenital primary aphakia (HP:0007707)	2.63123853
32	Sclerocornea (HP:0000647)	2.52833307
33	Nephrogenic diabetes insipidus (HP:0009806)	2.52626323
34	Increased hepatocellular lipid droplets (HP:0006565)	2.50313824
35	Failure to thrive in infancy (HP:0001531)	2.45703865
36	Abnormality of the labia minora (HP:0012880)	2.42618921
37	Pendular nystagmus (HP:0012043)	2.39952080
38	Septo-optic dysplasia (HP:0100842)	2.39226020
39	Congenital stationary night blindness (HP:0007642)	2.39189362
40	Lipid accumulation in hepatocytes (HP:0006561)	2.37900507
41	Lissencephaly (HP:0001339)	2.35711977
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.34415759
43	Anencephaly (HP:0002323)	2.33714603
44	Hyperglycinemia (HP:0002154)	2.26785179
45	Short tibia (HP:0005736)	2.25627317
46	Abnormal respiratory epithelium morphology (HP:0012253)	2.22005668
47	Abnormal respiratory motile cilium morphology (HP:0005938)	2.22005668
48	Stenosis of the external auditory canal (HP:0000402)	2.21475680
49	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.20103603
50	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.20103603
51	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.19016288
52	Growth hormone deficiency (HP:0000824)	2.17756354
53	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.16900097
54	Absent/shortened dynein arms (HP:0200106)	2.16900097
55	Pallor (HP:0000980)	2.15086525
56	Optic nerve hypoplasia (HP:0000609)	2.14279740
57	Type II lissencephaly (HP:0007260)	2.11994537
58	Abnormality of renal resorption (HP:0011038)	2.11268061
59	Elevated erythrocyte sedimentation rate (HP:0003565)	2.03623581
60	Cystic liver disease (HP:0006706)	2.02824036
61	Increased serum lactate (HP:0002151)	2.02416168
62	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.02129951
63	Increased intramyocellular lipid droplets (HP:0012240)	1.99899884
64	Lactic acidosis (HP:0003128)	1.99886856
65	Leukodystrophy (HP:0002415)	1.98337685
66	Oligodactyly (hands) (HP:0001180)	1.96458330
67	Vaginal atresia (HP:0000148)	1.94941516
68	Genital tract atresia (HP:0001827)	1.93999525
69	Abnormal ciliary motility (HP:0012262)	1.93453871
70	Abnormality of the renal medulla (HP:0100957)	1.93129152
71	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.92418927
72	Male pseudohermaphroditism (HP:0000037)	1.91578175
73	Poor coordination (HP:0002370)	1.89843707
74	Rib fusion (HP:0000902)	1.89774627
75	Depressed nasal ridge (HP:0000457)	1.89234127
76	Anophthalmia (HP:0000528)	1.88610845
77	Occipital encephalocele (HP:0002085)	1.88016224
78	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.87943561
79	Thyroid-stimulating hormone excess (HP:0002925)	1.87472011
80	Supernumerary spleens (HP:0009799)	1.86531185
81	Cerebellar dysplasia (HP:0007033)	1.86227826
82	Postaxial foot polydactyly (HP:0001830)	1.84796317
83	Asplenia (HP:0001746)	1.83292761
84	Adrenal hypoplasia (HP:0000835)	1.83145019
85	Abnormality of magnesium homeostasis (HP:0004921)	1.80795325
86	Postaxial hand polydactyly (HP:0001162)	1.80794040
87	Chronic hepatic failure (HP:0100626)	1.79272511
88	Tubular atrophy (HP:0000092)	1.78096987
89	Abnormality of the corticospinal tract (HP:0002492)	1.75783539
90	Oligomenorrhea (HP:0000876)	1.74788563
91	Pachygyria (HP:0001302)	1.74477235
92	Type 2 muscle fiber atrophy (HP:0003554)	1.74197647
93	Enlarged penis (HP:0000040)	1.73925550
94	Abnormal respiratory motile cilium physiology (HP:0012261)	1.73201216
95	Abolished electroretinogram (ERG) (HP:0000550)	1.72756824
96	Restlessness (HP:0000711)	1.70320038
97	Narrow forehead (HP:0000341)	1.69382667
98	Hypoplasia of the ulna (HP:0003022)	1.68641523
99	Respiratory failure (HP:0002878)	1.68579877
100	Abnormal hair whorl (HP:0010721)	1.68315590

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	2.95942979
2	BCKDK	2.85996211
3	DYRK2	2.85594691
4	TLK1	2.75133258
5	STK16	2.65339799
6	EPHB2	2.63305328
7	MAP4K2	2.54311507
8	WNK4	2.49587133
9	CDK19	2.38822817
10	CAMKK2	2.12600872
11	WNK3	2.11329377
12	MARK1	1.84099266
13	ADRBK2	1.83299999
14	MAP2K7	1.81174862
15	MAPK13	1.73832470
16	MINK1	1.70892167
17	LIMK1	1.70681990
18	NTRK2	1.66847760
19	DYRK3	1.63819014
20	PINK1	1.51850867
21	EPHA4	1.47210793
22	TNIK	1.45795387
23	GRK1	1.44487281
24	BMPR1B	1.38422970
25	DYRK1B	1.35464704
26	CSNK1G2	1.33214949
27	PIK3CA	1.24661216
28	PIM2	1.21817733
29	TNK2	1.21290141
30	CAMKK1	1.19098316
31	MAP3K4	1.18358836
32	PRKCG	1.15851666
33	MAP3K9	1.14604208
34	CSNK1G3	1.14285724
35	NUAK1	1.10623449
36	VRK1	1.10299019
37	PKN1	1.08492141
38	NTRK1	1.07536030
39	CASK	1.03559588
40	RPS6KA5	1.03170966
41	MAP3K11	1.02110013
42	BCR	0.99161823
43	NME2	0.98431586
44	SIK2	0.97631624
45	CAMK1	0.97354354
46	STK39	0.96392744
47	FRK	0.95996560
48	ABL2	0.95932536
49	ADRBK1	0.92658768
50	TYRO3	0.92246016
51	SGK494	0.91812245
52	SGK223	0.91812245
53	ILK	0.90585767
54	TXK	0.90125852
55	TRIM28	0.89914990
56	NME1	0.88082976
57	MAP3K12	0.87344622
58	CSNK1G1	0.87315350
59	PAK3	0.86376524
60	CSNK1A1L	0.86081406
61	CAMK4	0.81915626
62	TIE1	0.80379548
63	STK11	0.76951413
64	PLK2	0.75404382
65	AURKA	0.73384378
66	PRKCQ	0.73258543
67	TAOK3	0.73177218
68	VRK2	0.69713283
69	RPS6KA4	0.68939076
70	PRKACA	0.64654027
71	PRKCH	0.63616977
72	CAMK2A	0.63512084
73	SRPK1	0.61756790
74	OXSR1	0.61328038
75	PRKCD	0.57931507
76	KDR	0.57410139
77	NTRK3	0.56843808
78	GRK7	0.56464206
79	PRKCZ	0.55009245
80	BRAF	0.54626251
81	CSNK2A2	0.53784527
82	LRRK2	0.53516342
83	CDC7	0.53039089
84	SGK2	0.52831113
85	INSRR	0.52591145
86	UHMK1	0.52572037
87	DAPK3	0.52205018
88	FES	0.50379388
89	PAK1	0.48238905
90	CSNK2A1	0.48037762
91	DYRK1A	0.47298121
92	ARAF	0.46987798
93	PLK1	0.46481058
94	CSNK1E	0.45913497
95	CSNK1A1	0.44450930
96	CDK5	0.44255239
97	PRKCE	0.44227868
98	FLT3	0.43630339
99	CDK14	0.43127015
100	PRKCI	0.41790922

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.07951404
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.84605312
3	Parkinsons disease_Homo sapiens_hsa05012	4.18174818
4	Huntingtons disease_Homo sapiens_hsa05016	2.92752256
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.89091416
6	Alzheimers disease_Homo sapiens_hsa05010	2.85820180
7	Protein export_Homo sapiens_hsa03060	2.78481610
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.54004447
9	Phototransduction_Homo sapiens_hsa04744	2.50112851
10	RNA polymerase_Homo sapiens_hsa03020	2.20059511
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.18991173
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.14990475
13	Linoleic acid metabolism_Homo sapiens_hsa00591	2.06219567
14	Sulfur relay system_Homo sapiens_hsa04122	1.98356881
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.97386408
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.81425601
17	Proteasome_Homo sapiens_hsa03050	1.77051844
18	Nicotine addiction_Homo sapiens_hsa05033	1.74105846
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.72735247
20	Steroid biosynthesis_Homo sapiens_hsa00100	1.45608958
21	Basal transcription factors_Homo sapiens_hsa03022	1.44989001
22	Sulfur metabolism_Homo sapiens_hsa00920	1.43388881
23	Collecting duct acid secretion_Homo sapiens_hsa04966	1.26257627
24	Butanoate metabolism_Homo sapiens_hsa00650	1.24344053
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.21410069
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.16615358
27	Homologous recombination_Homo sapiens_hsa03440	1.14852622
28	Caffeine metabolism_Homo sapiens_hsa00232	1.14598915
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.13584781
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.10177813
31	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.08644968
32	Morphine addiction_Homo sapiens_hsa05032	1.05069668
33	Peroxisome_Homo sapiens_hsa04146	0.99695685
34	GABAergic synapse_Homo sapiens_hsa04727	0.97763721
35	Fat digestion and absorption_Homo sapiens_hsa04975	0.94756419
36	Fanconi anemia pathway_Homo sapiens_hsa03460	0.94313315
37	Propanoate metabolism_Homo sapiens_hsa00640	0.90198462
38	Nucleotide excision repair_Homo sapiens_hsa03420	0.89448382
39	RNA degradation_Homo sapiens_hsa03018	0.89393146
40	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.86943150
41	Glutamatergic synapse_Homo sapiens_hsa04724	0.81028244
42	Folate biosynthesis_Homo sapiens_hsa00790	0.80600108
43	Alcoholism_Homo sapiens_hsa05034	0.79473263
44	Base excision repair_Homo sapiens_hsa03410	0.79210673
45	Olfactory transduction_Homo sapiens_hsa04740	0.78754415
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.76517030
47	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.76178012
48	Insulin secretion_Homo sapiens_hsa04911	0.76089945
49	Axon guidance_Homo sapiens_hsa04360	0.76076639
50	Purine metabolism_Homo sapiens_hsa00230	0.75247393
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.72807550
52	Mismatch repair_Homo sapiens_hsa03430	0.72334560
53	Regulation of autophagy_Homo sapiens_hsa04140	0.71586671
54	Metabolic pathways_Homo sapiens_hsa01100	0.70443805
55	Serotonergic synapse_Homo sapiens_hsa04726	0.68992421
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.67973364
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66309870
58	Retinol metabolism_Homo sapiens_hsa00830	0.66109625
59	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.64896364
60	DNA replication_Homo sapiens_hsa03030	0.62920520
61	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.62508677
62	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.61670741
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61383367
64	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.60819623
65	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.60423388
66	Circadian entrainment_Homo sapiens_hsa04713	0.60412348
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60378736
68	Dopaminergic synapse_Homo sapiens_hsa04728	0.58854088
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.57878431
70	One carbon pool by folate_Homo sapiens_hsa00670	0.55081557
71	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.54312229
72	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.53191385
73	Basal cell carcinoma_Homo sapiens_hsa05217	0.51568999
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.48689963
75	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.46817162
76	Selenocompound metabolism_Homo sapiens_hsa00450	0.46468974
77	Nitrogen metabolism_Homo sapiens_hsa00910	0.43578715
78	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.42400305
79	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.40869851
80	Taste transduction_Homo sapiens_hsa04742	0.40821260
81	Cocaine addiction_Homo sapiens_hsa05030	0.39991355
82	Spliceosome_Homo sapiens_hsa03040	0.38257983
83	Glutathione metabolism_Homo sapiens_hsa00480	0.34963097
84	Cholinergic synapse_Homo sapiens_hsa04725	0.33752076
85	RNA transport_Homo sapiens_hsa03013	0.32761621
86	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.31326823
87	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.28909813
88	Long-term depression_Homo sapiens_hsa04730	0.28684658
89	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.24317159
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.24209493
91	Glycerolipid metabolism_Homo sapiens_hsa00561	0.23391029
92	Salivary secretion_Homo sapiens_hsa04970	0.22713435
93	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.22484266
94	p53 signaling pathway_Homo sapiens_hsa04115	0.22073808
95	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.21843888
96	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.21414887
97	Ras signaling pathway_Homo sapiens_hsa04014	0.20943678
98	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.20082780
99	Calcium signaling pathway_Homo sapiens_hsa04020	0.17795798
100	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.16981873

HIST1H3PS1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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