HIST1H4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1organ or tissue specific immune response (GO:0002251)8.34465570
2* DNA replication-dependent nucleosome assembly (GO:0006335)7.74496154
3* DNA replication-dependent nucleosome organization (GO:0034723)7.74496154
4regulation of histone H3-K9 methylation (GO:0051570)6.93087821
5chromatin assembly (GO:0031497)6.92444843
6regulation of posttranscriptional gene silencing (GO:0060147)6.56266010
7regulation of gene silencing by miRNA (GO:0060964)6.56266010
8regulation of gene silencing by RNA (GO:0060966)6.56266010
9nuclear pore complex assembly (GO:0051292)6.34684320
10nuclear pore organization (GO:0006999)6.29374218
11protein localization to kinetochore (GO:0034501)5.61716945
12* nucleosome assembly (GO:0006334)5.51730214
13DNA unwinding involved in DNA replication (GO:0006268)5.39027436
14folic acid-containing compound biosynthetic process (GO:0009396)5.38588332
15regulation of gene silencing (GO:0060968)5.32237507
16IMP biosynthetic process (GO:0006188)4.80946857
17pore complex assembly (GO:0046931)4.79507595
18* nucleosome organization (GO:0034728)4.77263090
19* chromatin assembly or disassembly (GO:0006333)4.72940204
20* protein-DNA complex assembly (GO:0065004)4.68812074
21viral mRNA export from host cell nucleus (GO:0046784)4.62661113
22protein localization to chromosome, centromeric region (GO:0071459)4.57643421
23DNA replication initiation (GO:0006270)4.53627943
24negative regulation of histone methylation (GO:0031061)4.45274067
25mitotic chromosome condensation (GO:0007076)4.43957516
26mitotic nuclear envelope disassembly (GO:0007077)4.33476463
27regulation of mammary gland epithelial cell proliferation (GO:0033599)4.33391513
28regulation of helicase activity (GO:0051095)4.26869978
29regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.26380158
30protein K6-linked ubiquitination (GO:0085020)4.25105825
31regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.25022803
32IMP metabolic process (GO:0046040)4.23955770
33regulation of translational fidelity (GO:0006450)4.21071451
34* protein-DNA complex subunit organization (GO:0071824)4.19475559
35sister chromatid segregation (GO:0000819)4.14896681
36nuclear envelope disassembly (GO:0051081)4.13378404
37membrane disassembly (GO:0030397)4.13378404
38antibacterial humoral response (GO:0019731)4.09431247
39DNA geometric change (GO:0032392)3.98723218
40nucleobase biosynthetic process (GO:0046112)3.98128907
41DNA duplex unwinding (GO:0032508)3.97760727
42pre-miRNA processing (GO:0031054)3.93814714
43DNA strand elongation involved in DNA replication (GO:0006271)3.91995557
44innate immune response in mucosa (GO:0002227)3.89812142
45negative regulation of DNA repair (GO:0045738)3.87327575
46antimicrobial humoral response (GO:0019730)3.82571644
47regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.79451973
48mitotic sister chromatid segregation (GO:0000070)3.78761545
49regulation of translational termination (GO:0006449)3.75639792
50negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.73821203
51DNA strand elongation (GO:0022616)3.68646724
52defense response to Gram-positive bacterium (GO:0050830)3.67804307
53establishment of apical/basal cell polarity (GO:0035089)3.64546235
54somatic hypermutation of immunoglobulin genes (GO:0016446)3.61748998
55somatic diversification of immune receptors via somatic mutation (GO:0002566)3.61748998
56positive regulation of chromosome segregation (GO:0051984)3.61612157
57mitotic metaphase plate congression (GO:0007080)3.61252083
58dosage compensation (GO:0007549)3.57668718
59positive regulation of SMAD protein import into nucleus (GO:0060391)3.54617979
60regulation of centrosome cycle (GO:0046605)3.53078778
61paraxial mesoderm development (GO:0048339)3.49772904
62replicative senescence (GO:0090399)3.47796242
63regulation of spindle organization (GO:0090224)3.46945362
64regulation of centriole replication (GO:0046599)3.46377388
65determination of adult lifespan (GO:0008340)3.44001714
66telomere maintenance via semi-conservative replication (GO:0032201)3.43272875
67viral transcription (GO:0019083)3.41556273
68purine nucleobase biosynthetic process (GO:0009113)3.41376403
69regulation of sister chromatid cohesion (GO:0007063)3.40643683
70regulation of mitotic spindle organization (GO:0060236)3.36386010
71metaphase plate congression (GO:0051310)3.34362710
72chromosome condensation (GO:0030261)3.34246285
73spindle assembly involved in mitosis (GO:0090307)3.32910934
74positive regulation of histone methylation (GO:0031062)3.31000889
75mitotic recombination (GO:0006312)3.27586127
76mitotic sister chromatid cohesion (GO:0007064)3.26947900
77histone H2A monoubiquitination (GO:0035518)3.22208902
78regulation of chromosome segregation (GO:0051983)3.21939317
79translational termination (GO:0006415)3.21831775
80spliceosomal tri-snRNP complex assembly (GO:0000244)3.19904509
81DNA conformation change (GO:0071103)3.17899902
82telomere maintenance via telomere lengthening (GO:0010833)3.17421493
83pseudouridine synthesis (GO:0001522)3.15897766
84DNA replication checkpoint (GO:0000076)3.12054079
85regulation of centrosome duplication (GO:0010824)3.10470064
86establishment of monopolar cell polarity (GO:0061162)3.09313857
87establishment or maintenance of monopolar cell polarity (GO:0061339)3.09313857
88spindle checkpoint (GO:0031577)3.07996888
89protein localization to chromosome (GO:0034502)3.07606977
90telomere maintenance via recombination (GO:0000722)3.07485911
91* chromatin remodeling at centromere (GO:0031055)3.05642772
92nuclear envelope organization (GO:0006998)3.05141299
93heterochromatin organization (GO:0070828)3.04648216
94natural killer cell mediated immunity (GO:0002228)3.04490181
95natural killer cell mediated cytotoxicity (GO:0042267)3.04490181
96positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.03470928
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.03470928
98positive regulation of mitotic sister chromatid separation (GO:1901970)3.03470928
99ribosomal large subunit biogenesis (GO:0042273)3.02949041
100hair cycle (GO:0042633)3.02775994
101molting cycle (GO:0042303)3.02775994
102peptidyl-arginine omega-N-methylation (GO:0035247)3.02672501
103tetrahydrofolate metabolic process (GO:0046653)3.01871474
104peptidyl-lysine dimethylation (GO:0018027)2.98551061
105establishment of chromosome localization (GO:0051303)2.97949984
106nucleotide-excision repair, DNA gap filling (GO:0006297)2.97534771
107regulation of RNA export from nucleus (GO:0046831)2.96180406
108regulation of SMAD protein import into nucleus (GO:0060390)2.95618534
109negative regulation of chromatin modification (GO:1903309)2.95610073
110regulation of DNA damage checkpoint (GO:2000001)2.94146265
111mucosal immune response (GO:0002385)2.93816194
112regulation of mitotic metaphase/anaphase transition (GO:0030071)2.93166941
113negative regulation of histone modification (GO:0031057)2.92291930
114attachment of spindle microtubules to kinetochore (GO:0008608)2.92254470
115translesion synthesis (GO:0019985)2.91294612
116mismatch repair (GO:0006298)2.91149772
117negative regulation of chromosome segregation (GO:0051985)2.90007981
118microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.89658938
119regulation of sister chromatid segregation (GO:0033045)2.86988868
120regulation of mitotic sister chromatid separation (GO:0010965)2.86988868
121regulation of mitotic sister chromatid segregation (GO:0033047)2.86988868
122deoxyribonucleotide biosynthetic process (GO:0009263)2.85969940
123DNA synthesis involved in DNA repair (GO:0000731)2.85650221
124regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.81604191
125cellular protein complex localization (GO:0034629)2.81435456
126mitotic spindle assembly checkpoint (GO:0007094)2.80558632
127negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.75840824
128negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.75840824
129negative regulation of mitotic sister chromatid segregation (GO:0033048)2.75840824
130negative regulation of mitotic sister chromatid separation (GO:2000816)2.75840824
131negative regulation of sister chromatid segregation (GO:0033046)2.75840824
132spindle assembly checkpoint (GO:0071173)2.75580771
133mitochondrial DNA metabolic process (GO:0032042)2.75571142
134rRNA transcription (GO:0009303)2.74746815
135mitotic spindle checkpoint (GO:0071174)2.70083589
136* telomere organization (GO:0032200)2.69418492
137translational elongation (GO:0006414)2.68454049
138* telomere maintenance (GO:0000723)2.67665963
139maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.65779788
140protein complex localization (GO:0031503)2.65280309
141kinetochore organization (GO:0051383)2.63539029
142response to UV-C (GO:0010225)2.63391142
143regulation of protein heterodimerization activity (GO:0043497)2.62871863
144ribosomal small subunit biogenesis (GO:0042274)2.62547275
145ribosome biogenesis (GO:0042254)2.62162588
146maturation of SSU-rRNA (GO:0030490)2.60568932
147nucleobase-containing small molecule interconversion (GO:0015949)2.60560323

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.19538000
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.42223521
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.13026510
4SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.67737675
5* BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.74766004
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.65975885
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50801680
8* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.48906537
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.48164412
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.31740790
11* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25255416
12* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18739358
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.14932925
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08522014
15* E2F1_21310950_ChIP-Seq_MCF-7_Human2.01055166
16* SOX2_16153702_ChIP-ChIP_HESCs_Human2.00807165
17* FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse13.4772440
18SOX2_18555785_ChIP-Seq_MESCs_Mouse1.97006454
19GATA1_22025678_ChIP-Seq_K562_Human1.92329350
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92289340
21* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.86447858
22SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.86128144
23* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.85176721
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.84355408
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81849508
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.76454188
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.73289382
28* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.69892348
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68332983
30POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.67538326
31* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.67474370
32* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65298191
33* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.59025922
34ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.54798487
35IRF1_19129219_ChIP-ChIP_H3396_Human1.52879643
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52151911
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51618551
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50834893
39AR_21909140_ChIP-Seq_LNCAP_Human1.50703506
40* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.48246784
41HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.40519583
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39245052
43* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.37485228
44KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.33429964
45KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.33429964
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.33429964
47HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31256178
48* NANOG_16153702_ChIP-ChIP_HESCs_Human1.30327547
49VDR_23849224_ChIP-Seq_CD4+_Human1.29777952
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29410664
51VDR_21846776_ChIP-Seq_THP-1_Human1.28415370
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.25500020
53NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.24100693
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23118265
55XRN2_22483619_ChIP-Seq_HELA_Human1.22459312
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22182635
57* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21757817
58ELK1_19687146_ChIP-ChIP_HELA_Human1.18903960
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18077375
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18015385
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17578314
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15428314
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13315184
64* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10419728
65ETS1_22383799_ChIP-Seq_G1ME_Mouse1.07635274
66* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07192041
67SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.06943430
68NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.04391263
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03411785
70DCP1A_22483619_ChIP-Seq_HELA_Human1.02203721
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01618443
72CIITA_25753668_ChIP-Seq_RAJI_Human1.01061555
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99103229
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98988883
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98187104
76ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98127460
77* FOXP3_21729870_ChIP-Seq_TREG_Human0.95812891
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95694010
79* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95427413
80NOTCH1_21737748_ChIP-Seq_TLL_Human0.94468580
81KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.92625092
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91679484
83THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91055516
84NANOG_21062744_ChIP-ChIP_HESCs_Human0.90469930
85BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90084111
86EST1_17652178_ChIP-ChIP_JURKAT_Human0.89495794
87* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89282276
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89268700
89PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89130194
90* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86705804
91ETS1_20019798_ChIP-Seq_JURKAT_Human0.86522576
92MYC_22102868_ChIP-Seq_BL_Human0.86476194
93* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85665800
94TTF2_22483619_ChIP-Seq_HELA_Human0.83880711
95* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.82181264
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.80881286
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80813501
98NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80630224
99POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.80593861
100PKCTHETA_26484144_Chip-Seq_BREAST_Human0.80046404
101KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79739007
102* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.77982034
103MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.75734941
104MAF_26560356_Chip-Seq_TH1_Human0.75692811
105* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.75604166
106SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.75397403
107HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.75354407
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74265364
109SOX2_18692474_ChIP-Seq_MEFs_Mouse0.73882982
110PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.73770252
111ZNF263_19887448_ChIP-Seq_K562_Human0.73673595
112FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.73120223
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.72675696
114SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.71612318
115YY1_21170310_ChIP-Seq_MESCs_Mouse0.71302111
116KDM5A_27292631_Chip-Seq_BREAST_Human0.69917382
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.68595450
118NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.68322225
119MYC_18940864_ChIP-ChIP_HL60_Human0.68048391
120PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.67986776
121CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.67697407
122GABP_17652178_ChIP-ChIP_JURKAT_Human0.67055492
123KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.63402933
124SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.63193874
125CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.61140872
126GABP_19822575_ChIP-Seq_HepG2_Human0.59419236
127* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.57319600

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.75408203
2MP0003111_abnormal_nucleus_morphology4.16199389
3MP0005083_abnormal_biliary_tract3.89101765
4MP0010307_abnormal_tumor_latency3.75829064
5MP0003077_abnormal_cell_cycle3.56325064
6MP0004957_abnormal_blastocyst_morpholog3.54536997
7MP0003693_abnormal_embryo_hatching3.40197223
8MP0010352_gastrointestinal_tract_polyps3.29877668
9MP0003705_abnormal_hypodermis_morpholog3.23918091
10MP0008057_abnormal_DNA_replication3.14157679
11MP0003123_paternal_imprinting3.05314129
12MP0009697_abnormal_copulation2.77497246
13MP0010234_abnormal_vibrissa_follicle2.72267260
14MP0009379_abnormal_foot_pigmentation2.64676100
15MP0005076_abnormal_cell_differentiation2.54091568
16MP0008932_abnormal_embryonic_tissue2.45635336
17MP0005171_absent_coat_pigmentation2.42497566
18MP0001730_embryonic_growth_arrest2.42130464
19MP0008058_abnormal_DNA_repair2.41653043
20MP0000350_abnormal_cell_proliferation2.36082051
21MP0002163_abnormal_gland_morphology2.18854558
22MP0002138_abnormal_hepatobiliary_system2.16834334
23MP0008007_abnormal_cellular_replicative2.11869041
24MP0002084_abnormal_developmental_patter2.08949587
25MP0003121_genomic_imprinting2.07406252
26MP0004197_abnormal_fetal_growth/weight/2.06513150
27MP0003806_abnormal_nucleotide_metabolis2.06227858
28MP0010030_abnormal_orbit_morphology2.00466682
29MP0002085_abnormal_embryonic_tissue1.99985534
30MP0002160_abnormal_reproductive_system1.99846295
31MP0000537_abnormal_urethra_morphology1.93730106
32MP0000372_irregular_coat_pigmentation1.92205204
33MP0002086_abnormal_extraembryonic_tissu1.89345114
34MP0001697_abnormal_embryo_size1.88719138
35MP0001672_abnormal_embryogenesis/_devel1.87371983
36MP0005380_embryogenesis_phenotype1.87371983
37MP0006035_abnormal_mitochondrial_morpho1.78741039
38MP0003941_abnormal_skin_development1.77920447
39MP0003763_abnormal_thymus_physiology1.73185294
40MP0002080_prenatal_lethality1.70519164
41MP0001293_anophthalmia1.65556114
42MP0005623_abnormal_meninges_morphology1.64126477
43MP0000685_abnormal_immune_system1.64090915
44MP0008877_abnormal_DNA_methylation1.63307013
45MP0005645_abnormal_hypothalamus_physiol1.62591037
46MP0001661_extended_life_span1.58393344
47MP0003984_embryonic_growth_retardation1.57380261
48MP0003937_abnormal_limbs/digits/tail_de1.56565603
49MP0002088_abnormal_embryonic_growth/wei1.56357254
50MP0002166_altered_tumor_susceptibility1.44562974
51MP0009053_abnormal_anal_canal1.44367078
52MP0003890_abnormal_embryonic-extraembry1.43762080
53MP0003786_premature_aging1.36661388
54MP0003119_abnormal_digestive_system1.36127874
55MP0002111_abnormal_tail_morphology1.34339458
56MP0001849_ear_inflammation1.32480037
57MP0000490_abnormal_crypts_of1.26518382
58MP0002697_abnormal_eye_size1.25009233
59MP0003136_yellow_coat_color1.22934948
60MP0003566_abnormal_cell_adhesion1.22411207
61MP0002092_abnormal_eye_morphology1.16677465
62MP0004185_abnormal_adipocyte_glucose1.16042407
63MP0002398_abnormal_bone_marrow1.15537545
64MP0000313_abnormal_cell_death1.15080751
65MP0005389_reproductive_system_phenotype1.14590531
66MP0000733_abnormal_muscle_development1.14234928
67MP0002722_abnormal_immune_system1.13801252
68MP0004134_abnormal_chest_morphology1.12190967
69MP0002019_abnormal_tumor_incidence1.11745958
70MP0008438_abnormal_cutaneous_collagen1.10968865
71MP0002006_tumorigenesis1.10910599
72MP0001915_intracranial_hemorrhage1.10850895
73MP0006054_spinal_hemorrhage1.09797115
74MP0002877_abnormal_melanocyte_morpholog1.08836808
75MP0003567_abnormal_fetal_cardiomyocyte1.07290098
76MP0004808_abnormal_hematopoietic_stem1.06987672
77MP0004133_heterotaxia1.06982539
78MP0002254_reproductive_system_inflammat1.05653051
79MP0005220_abnormal_exocrine_pancreas1.05516022
80MP0009703_decreased_birth_body1.05038539
81MP0000689_abnormal_spleen_morphology1.00466450
82MP0004233_abnormal_muscle_weight0.99985769
83MP0000678_abnormal_parathyroid_gland0.98861683
84MP0003656_abnormal_erythrocyte_physiolo0.98668528
85MP0001243_abnormal_dermal_layer0.98451020
86MP0003861_abnormal_nervous_system0.97879322
87MP0001346_abnormal_lacrimal_gland0.97694394
88MP0002210_abnormal_sex_determination0.94935070
89MP0000428_abnormal_craniofacial_morphol0.94229066
90MP0005023_abnormal_wound_healing0.93500147
91MP0005379_endocrine/exocrine_gland_phen0.92278622
92MP0003718_maternal_effect0.92109978
93MP0002139_abnormal_hepatobiliary_system0.91645672
94MP0001145_abnormal_male_reproductive0.90336715
95MP0001286_abnormal_eye_development0.89521397
96MP0002925_abnormal_cardiovascular_devel0.87685701
97MP0008770_decreased_survivor_rate0.86440960
98MP0003183_abnormal_peptide_metabolism0.85980704
99MP0009672_abnormal_birth_weight0.85828588
100MP0002928_abnormal_bile_duct0.85041382
101MP0000432_abnormal_head_morphology0.84967743
102MP0006072_abnormal_retinal_apoptosis0.83775227
103MP0003221_abnormal_cardiomyocyte_apopto0.83479720
104MP0001800_abnormal_humoral_immune0.82929011
105MP0003283_abnormal_digestive_organ0.82171677
106MP0000569_abnormal_digit_pigmentation0.80958133
107MP0001929_abnormal_gametogenesis0.80373183
108MP0005621_abnormal_cell_physiology0.79413597
109MP0005384_cellular_phenotype0.78610523
110MP0001727_abnormal_embryo_implantation0.78284137
111MP0000371_diluted_coat_color0.78230607
112MP0004264_abnormal_extraembryonic_tissu0.77393116
113MP0002009_preneoplasia0.75907227
114MP0002075_abnormal_coat/hair_pigmentati0.74976156
115MP0002429_abnormal_blood_cell0.74618756
116MP0004147_increased_porphyrin_level0.73568950
117MP0003935_abnormal_craniofacial_develop0.73375821
118MP0001119_abnormal_female_reproductive0.72477581
119MP0000703_abnormal_thymus_morphology0.72379720
120MP0003787_abnormal_imprinting0.72350979
121MP0000653_abnormal_sex_gland0.72180252
122MP0000516_abnormal_urinary_system0.71097431
123MP0005367_renal/urinary_system_phenotyp0.71097431
124MP0010678_abnormal_skin_adnexa0.70419490
125MP0004272_abnormal_basement_membrane0.70196664
126MP0005391_vision/eye_phenotype0.68441634
127MP0002396_abnormal_hematopoietic_system0.68408817
128MP0002822_catalepsy0.68019410
129MP0002282_abnormal_trachea_morphology0.67081663
130MP0003252_abnormal_bile_duct0.66783969
131MP0003385_abnormal_body_wall0.66741242
132MP0005501_abnormal_skin_physiology0.66519758
133MP0003091_abnormal_cell_migration0.66052838
134MP0005310_abnormal_salivary_gland0.64831447
135MP0000013_abnormal_adipose_tissue0.64691831
136MP0001191_abnormal_skin_condition0.64606347
137MP0001348_abnormal_lacrimal_gland0.64590877
138MP0003115_abnormal_respiratory_system0.62788339
139MP0002060_abnormal_skin_morphology0.62716501
140MP0000716_abnormal_immune_system0.62380724
141MP0000358_abnormal_cell_content/0.62036629
142MP0000003_abnormal_adipose_tissue0.61183334
143MP0008995_early_reproductive_senescence0.61166952
144MP0005266_abnormal_metabolism0.60218019
145MP0003755_abnormal_palate_morphology0.59729348
146MP0000477_abnormal_intestine_morphology0.58979695
147MP0003453_abnormal_keratinocyte_physiol0.58944313

Predicted human phenotypes

RankGene SetZ-score
1IgA deficiency (HP:0002720)4.94047629
2Ependymoma (HP:0002888)4.66411301
3Neoplasm of the heart (HP:0100544)4.25387808
4Abnormality of the labia minora (HP:0012880)4.07490557
5Oral leukoplakia (HP:0002745)4.03565291
6Down-sloping shoulders (HP:0200021)3.97593127
7IgM deficiency (HP:0002850)3.97071796
8Astrocytoma (HP:0009592)3.87342139
9Abnormality of the astrocytes (HP:0100707)3.87342139
10Abnormality of cells of the erythroid lineage (HP:0012130)3.79781313
11Agnosia (HP:0010524)3.71523976
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.69932630
13Abnormal number of erythroid precursors (HP:0012131)3.69570534
14Medulloblastoma (HP:0002885)3.69033713
15Abnormality of the parietal bone (HP:0002696)3.65722981
16Chromsome breakage (HP:0040012)3.65542442
17Deformed sella turcica (HP:0002681)3.58802528
18Rhabdomyosarcoma (HP:0002859)3.50539170
19Colon cancer (HP:0003003)3.42284692
20Squamous cell carcinoma (HP:0002860)3.30880835
21Neoplasm of the oral cavity (HP:0100649)3.23255249
22Glioma (HP:0009733)3.19310141
23Colitis (HP:0002583)3.18818048
24Reticulocytopenia (HP:0001896)3.18570996
25Selective tooth agenesis (HP:0001592)3.16406668
26Impulsivity (HP:0100710)3.09266783
27Biliary tract neoplasm (HP:0100574)3.03799176
28Abnormality of chromosome stability (HP:0003220)2.98505189
29Abnormality of the distal phalanx of the thumb (HP:0009617)2.97675108
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.96269164
31Short 4th metacarpal (HP:0010044)2.96269164
32Progressive muscle weakness (HP:0003323)2.91801384
33Short phalanx of the thumb (HP:0009660)2.91376537
34Missing ribs (HP:0000921)2.89091154
35Orthostatic hypotension (HP:0001278)2.86307600
36Birth length less than 3rd percentile (HP:0003561)2.84022305
37Rough bone trabeculation (HP:0100670)2.73077873
38Neoplasm of striated muscle (HP:0009728)2.72340396
39Spastic diplegia (HP:0001264)2.70945697
40Cortical dysplasia (HP:0002539)2.68591455
41Microvesicular hepatic steatosis (HP:0001414)2.63719028
42Hypopigmentation of the fundus (HP:0007894)2.62974191
43Basal cell carcinoma (HP:0002671)2.59594310
44Hypoplasia of the pons (HP:0012110)2.58360217
45Cutaneous melanoma (HP:0012056)2.52958424
46Gastrointestinal carcinoma (HP:0002672)2.51998858
47Malignant gastrointestinal tract tumors (HP:0006749)2.51998858
48Esophageal atresia (HP:0002032)2.50556916
49Absent radius (HP:0003974)2.50517709
50Cafe-au-lait spot (HP:0000957)2.48353109
51Abnormality of the sella turcica (HP:0002679)2.45875392
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.42356696
53Rectal prolapse (HP:0002035)2.40758886
54Clubbing of toes (HP:0100760)2.38791357
55Hemivertebrae (HP:0002937)2.37992945
56Deviation of the thumb (HP:0009603)2.37430686
57Sandal gap (HP:0001852)2.37137718
5811 pairs of ribs (HP:0000878)2.35859224
59Short humerus (HP:0005792)2.35402285
60Aplasia involving forearm bones (HP:0009822)2.32097595
61Absent forearm bone (HP:0003953)2.32097595
62Abnormality of abdominal situs (HP:0011620)2.31659641
63Abdominal situs inversus (HP:0003363)2.31659641
64Meckel diverticulum (HP:0002245)2.31437027
65Proximal placement of thumb (HP:0009623)2.31414504
66Bone marrow hypocellularity (HP:0005528)2.31079406
67Aplasia/Hypoplasia of the sacrum (HP:0008517)2.30065085
68Freckling (HP:0001480)2.29465878
69Amaurosis fugax (HP:0100576)2.28586471
70Milia (HP:0001056)2.25815177
71Abnormality of the pons (HP:0007361)2.25171307
72Duodenal stenosis (HP:0100867)2.24669457
73Small intestinal stenosis (HP:0012848)2.24669457
74Anomalous pulmonary venous return (HP:0010772)2.24071613
75Gastrointestinal stroma tumor (HP:0100723)2.23627174
76Aplasia/hypoplasia of the humerus (HP:0006507)2.20751844
77Abnormality of the ileum (HP:0001549)2.19526220
78Cellulitis (HP:0100658)2.16928270
79Neoplasm of the pancreas (HP:0002894)2.16407588
80Abnormal ossification of hand bones (HP:0005921)2.15340572
81Redundant skin (HP:0001582)2.14994241
82Supernumerary spleens (HP:0009799)2.14765391
83Broad ribs (HP:0000885)2.14762982
84Prominent nose (HP:0000448)2.14667587
85Sensory axonal neuropathy (HP:0003390)2.14032025
86Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.12435890
87Ectopic kidney (HP:0000086)2.11722616
88Sloping forehead (HP:0000340)2.11603739
89Abnormal trabecular bone morphology (HP:0100671)2.08899805
90Duplicated collecting system (HP:0000081)2.08442161
91Abnormality of pyrimidine metabolism (HP:0004353)2.07380099
92Abnormal hand bone ossification (HP:0010660)2.07029016
93Arteriovenous malformation (HP:0100026)2.06387971
94Abnormality of DNA repair (HP:0003254)2.06360445
95Premature graying of hair (HP:0002216)2.06321030
96Abnormality of the renal collecting system (HP:0004742)2.06263080
97Increased nuchal translucency (HP:0010880)2.06219151
98Abnormality of cochlea (HP:0000375)2.06054266
99Lymphoma (HP:0002665)2.04680863
100Aplastic anemia (HP:0001915)2.03823461
101Abnormality of the 4th metacarpal (HP:0010012)2.03620007
102Ovarian neoplasm (HP:0100615)2.03591116
103Abnormality of the pulmonary veins (HP:0011718)2.02193837
104B lymphocytopenia (HP:0010976)2.01439809
105Abnormality of the preputium (HP:0100587)2.01343025
106High pitched voice (HP:0001620)2.00970599
107Abnormality of the duodenum (HP:0002246)2.00513965
108Absent thumb (HP:0009777)1.99541229
109Heterotopia (HP:0002282)1.99377491
110Skull defect (HP:0001362)1.99002886
111Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.98694866
112Chronic diarrhea (HP:0002028)1.97496488
113Aplasia/Hypoplasia of the sternum (HP:0006714)1.97198054
114Ridged nail (HP:0001807)1.96263927
115Angiofibromas (HP:0010615)1.94835622
116Adenoma sebaceum (HP:0009720)1.94835622
117Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.94555578
118Patellar aplasia (HP:0006443)1.93920786
119Horseshoe kidney (HP:0000085)1.92804987
120Hamartoma (HP:0010566)1.92637864
121Intestinal polyposis (HP:0200008)1.92443743
122Hyperacusis (HP:0010780)1.91438789
123Intestinal polyp (HP:0005266)1.91120149
124Abnormality of the antihelix (HP:0009738)1.90485124
125Abnormality of reticulocytes (HP:0004312)1.90403601
126Atresia of the external auditory canal (HP:0000413)1.90370329
127Carpal bone hypoplasia (HP:0001498)1.90195022
128Progressive external ophthalmoplegia (HP:0000590)1.89764906
129Myelodysplasia (HP:0002863)1.89144865
130Death in childhood (HP:0003819)1.88683311
131Abnormality of the carotid arteries (HP:0005344)1.88078852
132Vertebral fusion (HP:0002948)1.87828843
133Nephroblastoma (Wilms tumor) (HP:0002667)1.87551771
134Ankle contracture (HP:0006466)1.86944619
135Abnormality of the salivary glands (HP:0010286)1.86228074
136Uterine neoplasm (HP:0010784)1.84498190
137Leukopenia (HP:0001882)1.83770705
138Cellular immunodeficiency (HP:0005374)1.83588399
139Insomnia (HP:0100785)1.83247324
140Increased serum ferritin (HP:0003281)1.83213355
141Neoplasm of the small intestine (HP:0100833)1.82817459
142Acute lymphatic leukemia (HP:0006721)1.82525392
143Abnormal number of incisors (HP:0011064)1.82125617
144Ureteral obstruction (HP:0006000)1.81947051
145Breast hypoplasia (HP:0003187)1.81416551
146Pallor (HP:0000980)1.80508772
147Spinal muscular atrophy (HP:0007269)1.79827592
148Large earlobe (HP:0009748)1.79810097
149Neoplasm of the colon (HP:0100273)1.79446516
150Fibrous tissue neoplasm (HP:0012316)1.78535878
151Neoplasm of the rectum (HP:0100743)1.76507276
152Supernumerary ribs (HP:0005815)1.75791862
153Sparse lateral eyebrow (HP:0005338)1.75724438
154Abnormal lung lobation (HP:0002101)1.75339317
155Abnormality of the lower motor neuron (HP:0002366)1.74797381
156Spinal cord lesions (HP:0100561)1.74718667
157Syringomyelia (HP:0003396)1.74718667
158Benign neoplasm of the central nervous system (HP:0100835)1.74466965
159Aplasia/Hypoplasia of the patella (HP:0006498)1.74443557
160Short thumb (HP:0009778)1.74418292
161Ulnar bowing (HP:0003031)1.74097823
162Hypergonadotropic hypogonadism (HP:0000815)1.73893163
163Deep palmar crease (HP:0006191)1.73471343
164Fibroma (HP:0010614)1.73382722
165Abnormal biliary tract morphology (HP:0012440)1.73296672
166Recurrent bronchitis (HP:0002837)1.72122428
167Thyroiditis (HP:0100646)1.71931920
168Volvulus (HP:0002580)1.70808193
169Gastrointestinal atresia (HP:0002589)1.69141929
170Renovascular hypertension (HP:0100817)1.68111562
171Tracheoesophageal fistula (HP:0002575)1.67409783

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK6.53359103
2VRK13.58485100
3CDC72.84192845
4RPS6KA52.36469385
5EPHA22.22873398
6WEE12.08540339
7STK42.06767616
8BUB12.04194294
9PKN22.02108289
10TLK110.2095570
11SCYL21.85811164
12NEK21.83988599
13CDK121.71255442
14EEF2K1.63026040
15SRPK11.59916219
16CDK91.58560580
17PIM11.56766089
18RPS6KB21.53933069
19NEK11.48404857
20FLT31.47561308
21TTK1.36224483
22AURKB1.35612687
23CHEK21.31781191
24MAP3K81.29881547
25MAP3K101.29244670
26TRIB31.15403474
27SMG11.11166590
28PKN11.10208711
29AURKA1.04975097
30PLK11.04909012
31PASK1.04344189
32DAPK31.02599173
33ATR0.98034865
34TAF10.95072381
35ACVR1B0.90482761
36MET0.83127082
37TTN0.81857847
38CDK70.81497072
39DYRK30.80888109
40MELK0.76531950
41CHEK10.75699565
42CCNB10.74839214
43PLK30.72053465
44CDK80.69122523
45CDK40.68848592
46KSR10.66031199
47ATM0.65580861
48MAP2K30.63998866
49STK160.63453728
50CAMK40.62635243
51AKT20.61462176
52LATS10.60801671
53CDK20.60591329
54EIF2AK10.59014342
55TSSK60.58923302
56PRPF4B0.56157797
57ALK0.54982563
58PLK40.54901103
59MAPK110.54715142
60PAK40.53905180
61MAP3K90.52497140
62MAP2K70.51635689
63PRKCQ0.51370559
64CSNK1D0.50255080
65STK100.49518301
66BLK0.49252739
67BTK0.48645573
68BRD40.48097726
69TGFBR10.46046156
70BRSK20.45485507
71MTOR0.43895697
72CDK10.43436154
73TESK20.43306116
74KSR20.43229607
75IRAK30.42829861
76PAK10.42027058
77NEK90.38945351
78PDGFRA0.38134223
79STK30.37228471
80CAMK1D0.37195557
81EIF2AK30.37126969
82BRAF0.36613701
83BMX0.35935075
84CDK60.35807687
85ERBB40.35543423
86GRK60.34044742
87ROCK10.33049860
88FGFR10.32372753
89BRSK10.32158724
90FGFR20.31615152
91MAP2K40.31151255
92EPHA30.30814340
93JAK20.29996655
94PRKDC0.28741356
95RIPK10.28552237
96FGR0.28306037
97EIF2AK20.27898593
98PAK20.27411930
99PRKCI0.24022931
100DYRK1B0.23891754
101RAF10.23494094
102IKBKB0.23158566
103CSNK2A20.22429835
104PIM20.21983274
105PDK30.21838611
106PDK40.21838611
107MAP3K40.21499009
108SIK10.21388874
109LRRK20.21170952
110MAPK140.20315439
111RPS6KB10.18447849
112PTK60.18224959
113TESK10.17580459
114IRAK40.17387312
115RPS6KA40.17225784
116SYK0.17144105
117ICK0.16277792
118AKT10.16223973
119LATS20.15725178
120PDK20.15463962
121FRK0.15327895
122PRKAA10.14358525
123NME20.14292761
124CSNK1G30.13965380
125PBK0.13666005
126MAPK10.13175601
127RET0.12933126
128CSNK1G10.12931913
129MAPKAPK30.12673561
130PRKCH0.12557310
131MAP3K20.12454486
132KDR0.12127535
133CSNK1A1L0.09812208
134PRKCD0.09200927
135RPS6KC10.09189059
136RPS6KL10.09189059
137MST40.09132930
138JAK10.07673493
139MAP3K140.07126456
140LYN0.06625719
141MAPKAPK50.06295911
142SGK10.04463091
143RPS6KA60.03450408
144CLK10.03172312
145NEK60.03110148

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050345.96131100
2DNA replication_Homo sapiens_hsa030303.18330437
3Mismatch repair_Homo sapiens_hsa034303.18067786
4* Viral carcinogenesis_Homo sapiens_hsa052033.00311088
5One carbon pool by folate_Homo sapiens_hsa006702.73744685
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.53506313
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21565187
8RNA transport_Homo sapiens_hsa030132.15364978
9Cell cycle_Homo sapiens_hsa041102.05001698
10* Systemic lupus erythematosus_Homo sapiens_hsa0532210.5244477
11Nucleotide excision repair_Homo sapiens_hsa034201.92418455
12Transcriptional misregulation in cancer_Homo sapiens_hsa052021.77391040
13Spliceosome_Homo sapiens_hsa030401.74856895
14Non-homologous end-joining_Homo sapiens_hsa034501.63268021
15Fanconi anemia pathway_Homo sapiens_hsa034601.58304012
16Homologous recombination_Homo sapiens_hsa034401.55823238
17Base excision repair_Homo sapiens_hsa034101.45687682
18Ribosome_Homo sapiens_hsa030101.38619317
19p53 signaling pathway_Homo sapiens_hsa041151.24847644
20mRNA surveillance pathway_Homo sapiens_hsa030151.22830454
21RNA polymerase_Homo sapiens_hsa030201.08200376
22Selenocompound metabolism_Homo sapiens_hsa004501.07736948
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07710825
24MicroRNAs in cancer_Homo sapiens_hsa052061.02007790
25Pyrimidine metabolism_Homo sapiens_hsa002400.91198470
26Intestinal immune network for IgA production_Homo sapiens_hsa046720.88499971
27Primary immunodeficiency_Homo sapiens_hsa053400.84606705
28RNA degradation_Homo sapiens_hsa030180.81643132
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79451286
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79271709
31Oocyte meiosis_Homo sapiens_hsa041140.78500367
32Nitrogen metabolism_Homo sapiens_hsa009100.73526998
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68090878
34Biosynthesis of amino acids_Homo sapiens_hsa012300.66783541
35Basal transcription factors_Homo sapiens_hsa030220.66711743
36B cell receptor signaling pathway_Homo sapiens_hsa046620.66074001
37Central carbon metabolism in cancer_Homo sapiens_hsa052300.64350092
38Bladder cancer_Homo sapiens_hsa052190.63553007
39Small cell lung cancer_Homo sapiens_hsa052220.63246461
40HTLV-I infection_Homo sapiens_hsa051660.61420003
41Hippo signaling pathway_Homo sapiens_hsa043900.57898500
42Epstein-Barr virus infection_Homo sapiens_hsa051690.54858292
43Colorectal cancer_Homo sapiens_hsa052100.52200807
44Basal cell carcinoma_Homo sapiens_hsa052170.51799595
45mTOR signaling pathway_Homo sapiens_hsa041500.49657078
46Chronic myeloid leukemia_Homo sapiens_hsa052200.49564683
47TGF-beta signaling pathway_Homo sapiens_hsa043500.49281793
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.46156880
49Lysine degradation_Homo sapiens_hsa003100.41125388
50Proteasome_Homo sapiens_hsa030500.40052544
51Adherens junction_Homo sapiens_hsa045200.38439915
52Purine metabolism_Homo sapiens_hsa002300.38307084
53Apoptosis_Homo sapiens_hsa042100.38028278
54Herpes simplex infection_Homo sapiens_hsa051680.35676114
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35225648
56Non-small cell lung cancer_Homo sapiens_hsa052230.34526996
57N-Glycan biosynthesis_Homo sapiens_hsa005100.34361168
58Tight junction_Homo sapiens_hsa045300.34221968
59Proteoglycans in cancer_Homo sapiens_hsa052050.32278538
60Melanoma_Homo sapiens_hsa052180.30436532
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30297058
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30073054
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.29543834
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.29438020
65Allograft rejection_Homo sapiens_hsa053300.29270093
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.28728040
67Antigen processing and presentation_Homo sapiens_hsa046120.28108099
68Notch signaling pathway_Homo sapiens_hsa043300.27529697
69Pentose phosphate pathway_Homo sapiens_hsa000300.27515226
70Asthma_Homo sapiens_hsa053100.27251909
71Autoimmune thyroid disease_Homo sapiens_hsa053200.27035048
72Thyroid cancer_Homo sapiens_hsa052160.26733712
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26477739
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26241667
75Acute myeloid leukemia_Homo sapiens_hsa052210.26193659
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25996308
77Carbon metabolism_Homo sapiens_hsa012000.25437542
78Fructose and mannose metabolism_Homo sapiens_hsa000510.24751649
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23748129
80Pathways in cancer_Homo sapiens_hsa052000.22432715
81Hedgehog signaling pathway_Homo sapiens_hsa043400.22285481
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22203179
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21261233
84Renin-angiotensin system_Homo sapiens_hsa046140.20471705
85Endometrial cancer_Homo sapiens_hsa052130.20077316
86Glioma_Homo sapiens_hsa052140.19680705
87FoxO signaling pathway_Homo sapiens_hsa040680.19473672
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18450323
89Prostate cancer_Homo sapiens_hsa052150.18389507
90Hepatitis B_Homo sapiens_hsa051610.18195762
91Focal adhesion_Homo sapiens_hsa045100.17753773
92Measles_Homo sapiens_hsa051620.16471910
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15956061
94Influenza A_Homo sapiens_hsa051640.15843833
95HIF-1 signaling pathway_Homo sapiens_hsa040660.15344332
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.15124043
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.14838007
98Viral myocarditis_Homo sapiens_hsa054160.14330596
99Graft-versus-host disease_Homo sapiens_hsa053320.13801236
100Vitamin B6 metabolism_Homo sapiens_hsa007500.13746893
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13306298
102ECM-receptor interaction_Homo sapiens_hsa045120.12753364
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.12556225
104Pancreatic cancer_Homo sapiens_hsa052120.12358615
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12283543
106Legionellosis_Homo sapiens_hsa051340.10621064
107Sulfur relay system_Homo sapiens_hsa041220.10450356
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.10037666
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.09588362
110Galactose metabolism_Homo sapiens_hsa000520.08896962
111ErbB signaling pathway_Homo sapiens_hsa040120.08671361
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08633943
113Wnt signaling pathway_Homo sapiens_hsa043100.08422789
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.08224030
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.08161295
116Huntingtons disease_Homo sapiens_hsa050160.07796122
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.07585887
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.07422312
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.06158873
120Type I diabetes mellitus_Homo sapiens_hsa049400.05860092
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.05610421
122Inositol phosphate metabolism_Homo sapiens_hsa005620.05489537
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.05473883
124Prolactin signaling pathway_Homo sapiens_hsa049170.05458241
125AMPK signaling pathway_Homo sapiens_hsa041520.04707978
126Glucagon signaling pathway_Homo sapiens_hsa049220.04553203
127Folate biosynthesis_Homo sapiens_hsa007900.04301888
128Hematopoietic cell lineage_Homo sapiens_hsa046400.03796837
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.03637527
130Arginine biosynthesis_Homo sapiens_hsa002200.03035132
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.01269729
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.01155561
133Insulin signaling pathway_Homo sapiens_hsa049100.01152756

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