HIST1H4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome organization (GO:0034723)8.97497304
2DNA replication-dependent nucleosome assembly (GO:0006335)8.97497304
3chromatin assembly (GO:0031497)7.53085592
4regulation of histone H3-K9 methylation (GO:0051570)7.00140466
5nuclear pore complex assembly (GO:0051292)6.50746059
6nuclear pore organization (GO:0006999)6.33704917
7nucleosome assembly (GO:0006334)6.33356948
8DNA unwinding involved in DNA replication (GO:0006268)5.79108377
9protein localization to kinetochore (GO:0034501)5.54470241
10chromatin assembly or disassembly (GO:0006333)5.52710084
11nucleosome organization (GO:0034728)5.43191965
12protein-DNA complex assembly (GO:0065004)5.32033819
13folic acid-containing compound biosynthetic process (GO:0009396)5.31675418
14mitotic chromosome condensation (GO:0007076)5.15596709
15pore complex assembly (GO:0046931)4.99732150
16antibacterial humoral response (GO:0019731)4.98415479
17innate immune response in mucosa (GO:0002227)4.75228184
18protein-DNA complex subunit organization (GO:0071824)4.72213865
19antimicrobial humoral response (GO:0019730)4.68326289
20sister chromatid segregation (GO:0000819)4.66100934
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.64670226
22protein localization to chromosome, centromeric region (GO:0071459)4.58235550
23DNA replication initiation (GO:0006270)4.50401470
24IMP biosynthetic process (GO:0006188)4.44983687
25mitotic nuclear envelope disassembly (GO:0007077)4.28396559
26regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.24810701
27replicative senescence (GO:0090399)4.24064409
28DNA duplex unwinding (GO:0032508)4.20506589
29DNA geometric change (GO:0032392)4.19276293
30chromatin remodeling at centromere (GO:0031055)4.16913309
31regulation of gene silencing (GO:0060968)4.14887010
32mitotic sister chromatid segregation (GO:0000070)4.12794691
33CENP-A containing nucleosome assembly (GO:0034080)4.09154328
34membrane disassembly (GO:0030397)4.07900945
35nuclear envelope disassembly (GO:0051081)4.07900945
36negative regulation of histone methylation (GO:0031061)4.05588053
37regulation of translational fidelity (GO:0006450)4.02714551
38IMP metabolic process (GO:0046040)4.00973739
39DNA strand elongation involved in DNA replication (GO:0006271)4.00055325
40viral mRNA export from host cell nucleus (GO:0046784)3.96775206
41regulation of centriole replication (GO:0046599)3.92331660
42protein K6-linked ubiquitination (GO:0085020)3.89837253
43dosage compensation (GO:0007549)3.88850763
44regulation of posttranscriptional gene silencing (GO:0060147)3.86445243
45regulation of gene silencing by miRNA (GO:0060964)3.86445243
46regulation of gene silencing by RNA (GO:0060966)3.86445243
47positive regulation of chromosome segregation (GO:0051984)3.82384363
48DNA strand elongation (GO:0022616)3.77795314
49regulation of megakaryocyte differentiation (GO:0045652)3.71103691
50telomere maintenance via semi-conservative replication (GO:0032201)3.67792422
51DNA replication-independent nucleosome assembly (GO:0006336)3.67755120
52DNA replication-independent nucleosome organization (GO:0034724)3.67755120
53mitotic recombination (GO:0006312)3.63462959
54regulation of centrosome cycle (GO:0046605)3.62480017
55positive regulation of mitotic sister chromatid separation (GO:1901970)3.60159626
56positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.60159626
57positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.60159626
58mucosal immune response (GO:0002385)3.59489279
59regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.58616493
60cellular protein complex localization (GO:0034629)3.56522819
61chromosome condensation (GO:0030261)3.49824032
62regulation of sister chromatid cohesion (GO:0007063)3.49670326
63peptidyl-lysine dimethylation (GO:0018027)3.46223374
64translesion synthesis (GO:0019985)3.46000951
65DNA replication checkpoint (GO:0000076)3.43567820
66mitotic sister chromatid cohesion (GO:0007064)3.42524917
67regulation of mammary gland epithelial cell proliferation (GO:0033599)3.42006641
68protein complex localization (GO:0031503)3.40471682
69organ or tissue specific immune response (GO:0002251)3.38817650
70histone exchange (GO:0043486)3.37359266
71telomere maintenance via recombination (GO:0000722)3.36517070
72negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.35047658
73DNA conformation change (GO:0071103)3.34516482
74nucleobase biosynthetic process (GO:0046112)3.32640161
75regulation of helicase activity (GO:0051095)3.32353770
76regulation of centrosome duplication (GO:0010824)3.30127223
77regulation of translational termination (GO:0006449)3.29106538
78regulation of spindle organization (GO:0090224)3.26592948
79nucleobase-containing small molecule interconversion (GO:0015949)3.25029015
80regulation of RNA export from nucleus (GO:0046831)3.24159687
81positive regulation of histone methylation (GO:0031062)3.23249758
82postreplication repair (GO:0006301)3.22963344
83non-recombinational repair (GO:0000726)3.22734844
84double-strand break repair via nonhomologous end joining (GO:0006303)3.22734844
85telomere maintenance via telomere lengthening (GO:0010833)3.21474817
86kinetochore organization (GO:0051383)3.21159089
87attachment of spindle microtubules to kinetochore (GO:0008608)3.20124025
88pre-miRNA processing (GO:0031054)3.20033793
89meiotic chromosome segregation (GO:0045132)3.18157057
90viral transcription (GO:0019083)3.18058805
91translational termination (GO:0006415)3.17159018
92mitochondrial DNA metabolic process (GO:0032042)3.16114297
93defense response to Gram-positive bacterium (GO:0050830)3.15250201
94regulation of chromosome segregation (GO:0051983)3.15002796
95DNA topological change (GO:0006265)3.12755303
96determination of adult lifespan (GO:0008340)3.10928938
97ribosomal small subunit assembly (GO:0000028)3.10163699
98nucleotide-excision repair, DNA gap filling (GO:0006297)3.09837933
99regulation of DNA endoreduplication (GO:0032875)3.08690461
100mitotic G1 DNA damage checkpoint (GO:0031571)3.07777585
101mitotic metaphase plate congression (GO:0007080)3.07575848
102negative regulation of chromosome segregation (GO:0051985)3.07205121
103nuclear envelope organization (GO:0006998)3.06664716
104tetrahydrofolate metabolic process (GO:0046653)3.05586789
105somatic hypermutation of immunoglobulin genes (GO:0016446)3.05445127
106somatic diversification of immune receptors via somatic mutation (GO:0002566)3.05445127
107telomere maintenance (GO:0000723)3.04740593
108protein localization to chromosome (GO:0034502)3.03562214
109regulation of mitotic spindle organization (GO:0060236)3.03109829
110regulation of DNA damage checkpoint (GO:2000001)3.02544383
111DNA synthesis involved in DNA repair (GO:0000731)3.01808834
112telomere organization (GO:0032200)3.00917269
113DNA packaging (GO:0006323)2.98887516
114negative regulation of DNA repair (GO:0045738)2.98636343
115spindle checkpoint (GO:0031577)2.98231486
116ribosomal large subunit biogenesis (GO:0042273)2.98229608
117rRNA transcription (GO:0009303)2.97211825
118spindle assembly involved in mitosis (GO:0090307)2.96617274
119peptidyl-arginine omega-N-methylation (GO:0035247)2.93359627
120regulation of sister chromatid segregation (GO:0033045)2.93176352
121regulation of mitotic sister chromatid separation (GO:0010965)2.93176352
122regulation of mitotic sister chromatid segregation (GO:0033047)2.93176352
123regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.92839568
124regulation of mitotic metaphase/anaphase transition (GO:0030071)2.92839568
125ATP-dependent chromatin remodeling (GO:0043044)2.92728678
126mitotic spindle assembly checkpoint (GO:0007094)2.86310776
127positive regulation of cell cycle checkpoint (GO:1901978)2.84099751
128negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.82664559
129negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.82664559
130negative regulation of mitotic sister chromatid segregation (GO:0033048)2.82664559
131negative regulation of mitotic sister chromatid separation (GO:2000816)2.82664559
132negative regulation of sister chromatid segregation (GO:0033046)2.82664559
133spindle assembly checkpoint (GO:0071173)2.81680341
134proline biosynthetic process (GO:0006561)2.75649110
135mitotic spindle checkpoint (GO:0071174)2.74408472
136positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.69663228
137regulation of cell cycle checkpoint (GO:1901976)2.69368360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.46362196
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.64002485
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.32548197
4* SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.04328950
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.94278346
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59923971
7* BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.57735764
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.37575703
9* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.33642925
10* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.32306295
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.32190638
12* E2F1_21310950_ChIP-Seq_MCF-7_Human2.15190174
13* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09565647
14* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.02093087
15* FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse14.1073862
16SOX2_16153702_ChIP-ChIP_HESCs_Human1.96020956
17EGR1_19374776_ChIP-ChIP_THP-1_Human1.92600846
18MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91547483
19* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.88111583
20AR_21909140_ChIP-Seq_LNCAP_Human1.81762922
21MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79129432
22SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.77605377
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.67359811
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63197063
25ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62028384
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60358672
27IRF1_19129219_ChIP-ChIP_H3396_Human1.54449468
28SOX2_18555785_ChIP-Seq_MESCs_Mouse1.54166560
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46191589
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45997587
31KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.45905076
32HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.43526964
33TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39225412
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37704727
35* VDR_23849224_ChIP-Seq_CD4+_Human1.37362477
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.34523319
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34079870
38ELK1_19687146_ChIP-ChIP_HELA_Human1.33620646
39* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33587366
40* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28835568
41* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28452261
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27722539
43HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26712282
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25584282
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25346195
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24695484
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21949572
48MYC_22102868_ChIP-Seq_BL_Human1.20630395
49NANOG_16153702_ChIP-ChIP_HESCs_Human1.18872664
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14691455
51* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.10929194
52XRN2_22483619_ChIP-Seq_HELA_Human1.10550199
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09958749
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09723599
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08751231
56* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08663109
57* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.08238634
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03700677
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03623224
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03107500
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02188697
62CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99196545
63* FOXP3_21729870_ChIP-Seq_TREG_Human0.97857381
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94711806
65ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94290387
66ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92215469
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.92176702
68PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91842604
69BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91841290
70NOTCH1_21737748_ChIP-Seq_TLL_Human0.91166713
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.90140700
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89928839
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89559782
74HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.87914906
75* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87731590
76* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87669824
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.86909879
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85819102
79THAP11_20581084_ChIP-Seq_MESCs_Mouse0.84062977
80EST1_17652178_ChIP-ChIP_JURKAT_Human0.84032809
81TP63_17297297_ChIP-ChIP_HaCaT_Human0.83734275
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.78274635
83ETS1_20019798_ChIP-Seq_JURKAT_Human0.77461975
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77413903
85VDR_21846776_ChIP-Seq_THP-1_Human0.77304573
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77164309
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75903121
88KDM5A_27292631_Chip-Seq_BREAST_Human0.75765128
89* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.75655386
90TTF2_22483619_ChIP-Seq_HELA_Human0.73276584
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.72822281
92* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.72462721
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.72389437
94SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.70810488
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.70680956
96GATA1_22025678_ChIP-Seq_K562_Human0.70293842
97NANOG_21062744_ChIP-ChIP_HESCs_Human0.69913734
98HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.69440842
99NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.69323456
100* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.69051287
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.68648012
102DCP1A_22483619_ChIP-Seq_HELA_Human0.68078317
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.67729989
104SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.67094332
105MYC_18940864_ChIP-ChIP_HL60_Human0.66821942
106KLF4_18555785_ChIP-Seq_MESCs_Mouse0.66354535
107PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.66202418
108NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.64717964
109SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.64329577
110RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.64130915
111GABP_17652178_ChIP-ChIP_JURKAT_Human0.63977183
112CIITA_25753668_ChIP-Seq_RAJI_Human0.63626440
113GATA2_22383799_ChIP-Seq_G1ME_Mouse0.63176284
114POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.62983569
115TFEB_21752829_ChIP-Seq_HELA_Human0.62215941
116GABP_19822575_ChIP-Seq_HepG2_Human0.61693255
117ZNF263_19887448_ChIP-Seq_K562_Human0.60636049
118FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.60413386

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.89120551
2MP0010307_abnormal_tumor_latency4.18753743
3MP0003111_abnormal_nucleus_morphology4.14951354
4MP0003693_abnormal_embryo_hatching3.65596566
5MP0003077_abnormal_cell_cycle3.65298727
6MP0010352_gastrointestinal_tract_polyps3.41047679
7MP0004957_abnormal_blastocyst_morpholog3.27765934
8MP0003705_abnormal_hypodermis_morpholog3.14097539
9MP0008057_abnormal_DNA_replication2.91036148
10MP0010234_abnormal_vibrissa_follicle2.71182609
11MP0005076_abnormal_cell_differentiation2.38863936
12MP0008058_abnormal_DNA_repair2.33701002
13MP0000350_abnormal_cell_proliferation2.30787091
14MP0001730_embryonic_growth_arrest2.29390302
15MP0008007_abnormal_cellular_replicative2.20650614
16MP0003123_paternal_imprinting2.16527792
17MP0009697_abnormal_copulation2.09514307
18MP0008932_abnormal_embryonic_tissue2.06744060
19MP0002877_abnormal_melanocyte_morpholog2.04518892
20MP0001661_extended_life_span2.03152740
21MP0004197_abnormal_fetal_growth/weight/1.84775024
22MP0004808_abnormal_hematopoietic_stem1.77045004
23MP0002086_abnormal_extraembryonic_tissu1.73085992
24MP0001697_abnormal_embryo_size1.66772969
25MP0001672_abnormal_embryogenesis/_devel1.64101361
26MP0005380_embryogenesis_phenotype1.64101361
27MP0003121_genomic_imprinting1.63631058
28MP0003656_abnormal_erythrocyte_physiolo1.61366496
29MP0002084_abnormal_developmental_patter1.60340406
30MP0006054_spinal_hemorrhage1.57547936
31MP0002080_prenatal_lethality1.56306563
32MP0003941_abnormal_skin_development1.54937240
33MP0000490_abnormal_crypts_of1.54237509
34MP0002085_abnormal_embryonic_tissue1.53439395
35MP0005171_absent_coat_pigmentation1.49396810
36MP0000372_irregular_coat_pigmentation1.49248630
37MP0000537_abnormal_urethra_morphology1.48691497
38MP0002396_abnormal_hematopoietic_system1.47162035
39MP0000013_abnormal_adipose_tissue1.43636180
40MP0003984_embryonic_growth_retardation1.42918518
41MP0002019_abnormal_tumor_incidence1.42376936
42MP0002088_abnormal_embryonic_growth/wei1.41555032
43MP0002160_abnormal_reproductive_system1.40796003
44MP0000371_diluted_coat_color1.34815605
45MP0001293_anophthalmia1.34305422
46MP0008877_abnormal_DNA_methylation1.33111139
47MP0003786_premature_aging1.32222909
48MP0003566_abnormal_cell_adhesion1.27396474
49MP0004147_increased_porphyrin_level1.24403657
50MP0005408_hypopigmentation1.23158830
51MP0000313_abnormal_cell_death1.20808223
52MP0003300_gastrointestinal_ulcer1.20316640
53MP0003763_abnormal_thymus_physiology1.18851598
54MP0000733_abnormal_muscle_development1.18392366
55MP0005623_abnormal_meninges_morphology1.18289618
56MP0000003_abnormal_adipose_tissue1.17987864
57MP0006035_abnormal_mitochondrial_morpho1.17953231
58MP0010030_abnormal_orbit_morphology1.17907824
59MP0008438_abnormal_cutaneous_collagen1.14568002
60MP0002095_abnormal_skin_pigmentation1.12925928
61MP0000703_abnormal_thymus_morphology1.12050053
62MP0002092_abnormal_eye_morphology1.10954990
63MP0003806_abnormal_nucleotide_metabolis1.10405805
64MP0002697_abnormal_eye_size1.09905811
65MP0001915_intracranial_hemorrhage1.08095581
66MP0005023_abnormal_wound_healing1.05264489
67MP0000569_abnormal_digit_pigmentation1.05206716
68MP0002075_abnormal_coat/hair_pigmentati1.04994607
69MP0005220_abnormal_exocrine_pancreas1.02549353
70MP0003937_abnormal_limbs/digits/tail_de1.01997246
71MP0002163_abnormal_gland_morphology1.00482244
72MP0003385_abnormal_body_wall0.98170443
73MP0001346_abnormal_lacrimal_gland0.97666404
74MP0002722_abnormal_immune_system0.97072894
75MP0003890_abnormal_embryonic-extraembry0.96257171
76MP0009053_abnormal_anal_canal0.95757512
77MP0002166_altered_tumor_susceptibility0.95660610
78MP0003136_yellow_coat_color0.95639116
79MP0003567_abnormal_fetal_cardiomyocyte0.95580517
80MP0008770_decreased_survivor_rate0.95523234
81MP0004185_abnormal_adipocyte_glucose0.94606876
82MP0002398_abnormal_bone_marrow0.94386950
83MP0002111_abnormal_tail_morphology0.93377673
84MP0003221_abnormal_cardiomyocyte_apopto0.92775150
85MP0005645_abnormal_hypothalamus_physiol0.92765950
86MP0010678_abnormal_skin_adnexa0.91321750
87MP0000689_abnormal_spleen_morphology0.88957011
88MP0004134_abnormal_chest_morphology0.88595995
89MP0009703_decreased_birth_body0.88499113
90MP0002009_preneoplasia0.88240473
91MP0005621_abnormal_cell_physiology0.87032624
92MP0002060_abnormal_skin_morphology0.86875652
93MP0003315_abnormal_perineum_morphology0.85789251
94MP0003453_abnormal_keratinocyte_physiol0.85371676
95MP0002006_tumorigenesis0.83586358
96MP0005384_cellular_phenotype0.81647179
97MP0000747_muscle_weakness0.80551168
98MP0002138_abnormal_hepatobiliary_system0.80453849
99MP0005083_abnormal_biliary_tract0.78614672
100MP0001849_ear_inflammation0.78372375
101MP0003091_abnormal_cell_migration0.76104752
102MP0001186_pigmentation_phenotype0.75837024
103MP0005451_abnormal_body_composition0.73341223
104MP0001727_abnormal_embryo_implantation0.72236325
105MP0001243_abnormal_dermal_layer0.72204809
106MP0009672_abnormal_birth_weight0.72060406
107MP0003448_altered_tumor_morphology0.72013666
108MP0004233_abnormal_muscle_weight0.71468483
109MP0002925_abnormal_cardiovascular_devel0.70917356
110MP0000762_abnormal_tongue_morphology0.70721097
111MP0001348_abnormal_lacrimal_gland0.70632136
112MP0005397_hematopoietic_system_phenotyp0.68836078
113MP0001545_abnormal_hematopoietic_system0.68836078
114MP0005501_abnormal_skin_physiology0.67210882
115MP0001216_abnormal_epidermal_layer0.67022307
116MP0002429_abnormal_blood_cell0.66540509
117MP0000477_abnormal_intestine_morphology0.66031424
118MP0003252_abnormal_bile_duct0.65209381
119MP0003718_maternal_effect0.64434706
120MP0000358_abnormal_cell_content/0.64270579
121MP0000428_abnormal_craniofacial_morphol0.64098389
122MP0003935_abnormal_craniofacial_develop0.63672104
123MP0005257_abnormal_intraocular_pressure0.63260431
124MP0005275_abnormal_skin_tensile0.62933069
125MP0001286_abnormal_eye_development0.62842375
126MP0003787_abnormal_imprinting0.61592539
127MP0005187_abnormal_penis_morphology0.61449443
128MP0003303_peritoneal_inflammation0.61364161
129MP0001929_abnormal_gametogenesis0.59737937
130MP0005389_reproductive_system_phenotype0.59516097
131MP0009379_abnormal_foot_pigmentation0.58928163
132MP0001145_abnormal_male_reproductive0.58688353
133MP0003699_abnormal_female_reproductive0.58363033
134MP0009333_abnormal_splenocyte_physiolog0.57464758
135MP0000432_abnormal_head_morphology0.56382249

Predicted human phenotypes

RankGene SetZ-score
1IgA deficiency (HP:0002720)4.25539427
2Cutaneous melanoma (HP:0012056)4.18068433
3Oral leukoplakia (HP:0002745)4.12336212
4Ependymoma (HP:0002888)3.88416192
5IgM deficiency (HP:0002850)3.65817655
6Reticulocytopenia (HP:0001896)3.62199167
7Chromsome breakage (HP:0040012)3.56880744
8Abnormality of the astrocytes (HP:0100707)3.50654834
9Astrocytoma (HP:0009592)3.50654834
10Poikilocytosis (HP:0004447)3.45785071
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.44460355
12Rhabdomyosarcoma (HP:0002859)3.28221764
13Medulloblastoma (HP:0002885)3.22124509
14Abnormality of chromosome stability (HP:0003220)3.21634717
15Agnosia (HP:0010524)3.18283349
16Hypopigmentation of the fundus (HP:0007894)3.10386071
17Hypochromic microcytic anemia (HP:0004840)3.05073097
18Impulsivity (HP:0100710)2.99127502
19Colon cancer (HP:0003003)2.92974823
20Glioma (HP:0009733)2.92927048
21Colitis (HP:0002583)2.91952674
22Abnormality of the labia minora (HP:0012880)2.86073044
23Selective tooth agenesis (HP:0001592)2.83410179
24Basal cell carcinoma (HP:0002671)2.82641732
25Biliary tract neoplasm (HP:0100574)2.80523861
26Abnormality of reticulocytes (HP:0004312)2.76207233
27Birth length less than 3rd percentile (HP:0003561)2.75003007
28Acanthocytosis (HP:0001927)2.73911751
29Abnormality of the parietal bone (HP:0002696)2.73182576
30Freckling (HP:0001480)2.72332166
31Short 4th metacarpal (HP:0010044)2.71997693
32Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71997693
33Subacute progressive viral hepatitis (HP:0006572)2.68240472
34Neoplasm of the oral cavity (HP:0100649)2.62619321
35Rough bone trabeculation (HP:0100670)2.62205388
36Abnormality of the distal phalanx of the thumb (HP:0009617)2.59440658
37Cafe-au-lait spot (HP:0000957)2.59121524
38Spastic diplegia (HP:0001264)2.52418293
39Microvesicular hepatic steatosis (HP:0001414)2.52337286
40Aplasia/Hypoplasia of the sacrum (HP:0008517)2.48105141
41Neoplasm of striated muscle (HP:0009728)2.47259401
42Abnormality of cells of the erythroid lineage (HP:0012130)2.46137865
43Hypoplasia of the pons (HP:0012110)2.46041111
44High pitched voice (HP:0001620)2.45191506
45Sandal gap (HP:0001852)2.45030714
46Rectal prolapse (HP:0002035)2.40068636
47Gastrointestinal carcinoma (HP:0002672)2.37017680
48Malignant gastrointestinal tract tumors (HP:0006749)2.37017680
49Cortical dysplasia (HP:0002539)2.35098404
50Down-sloping shoulders (HP:0200021)2.35072733
51Volvulus (HP:0002580)2.33910264
52Prominent nose (HP:0000448)2.31922496
53Progressive muscle weakness (HP:0003323)2.31601806
54Clubbing of toes (HP:0100760)2.30172975
55Short thumb (HP:0009778)2.29693753
56Orthostatic hypotension (HP:0001278)2.28525884
57Reticulocytosis (HP:0001923)2.27836770
58Neoplasm of the heart (HP:0100544)2.27300034
59Deviation of the thumb (HP:0009603)2.26545388
60Squamous cell carcinoma (HP:0002860)2.25325650
61Ulnar bowing (HP:0003031)2.25209432
62Abnormality of the pons (HP:0007361)2.24160234
63Syringomyelia (HP:0003396)2.21198537
64Spinal cord lesions (HP:0100561)2.21198537
65Abnormality of DNA repair (HP:0003254)2.21029775
66Amaurosis fugax (HP:0100576)2.19779424
67Hyperacusis (HP:0010780)2.18954655
68Duplication of thumb phalanx (HP:0009942)2.18373278
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.17903853
70Nephroblastoma (Wilms tumor) (HP:0002667)2.17567910
71Ureteral duplication (HP:0000073)2.17309960
72Small intestinal stenosis (HP:0012848)2.15294759
73Duodenal stenosis (HP:0100867)2.15294759
74Absent frontal sinuses (HP:0002688)2.13740875
75Proximal placement of thumb (HP:0009623)2.13451800
76Abnormal trabecular bone morphology (HP:0100671)2.13210673
77Myelodysplasia (HP:0002863)2.12344334
78Abnormal ossification of hand bones (HP:0005921)2.11138077
79Meckel diverticulum (HP:0002245)2.10836147
80Increased nuchal translucency (HP:0010880)2.08403409
81Ovarian neoplasm (HP:0100615)2.08115554
82Heterotopia (HP:0002282)2.07082195
83Neoplasm of the pancreas (HP:0002894)2.07033622
84Arteriovenous malformation (HP:0100026)2.07003191
85Macrocytic anemia (HP:0001972)2.06143573
86Renovascular hypertension (HP:0100817)2.05737692
87Sloping forehead (HP:0000340)2.04559417
88Sensory axonal neuropathy (HP:0003390)2.04032240
89Abnormality of the ileum (HP:0001549)2.00323733
90Angiofibromas (HP:0010615)2.00254478
91Adenoma sebaceum (HP:0009720)2.00254478
92Embryonal renal neoplasm (HP:0011794)1.99269627
93Absent thumb (HP:0009777)1.97654429
94Cerebellar dysplasia (HP:0007033)1.97339322
9511 pairs of ribs (HP:0000878)1.95922249
96Missing ribs (HP:0000921)1.95846480
97Deformed sella turcica (HP:0002681)1.95751732
98Pallor (HP:0000980)1.95629892
99Abnormality of the preputium (HP:0100587)1.95601815
100Bone marrow hypocellularity (HP:0005528)1.95143261
101Intestinal polyposis (HP:0200008)1.94823013
102Entropion (HP:0000621)1.94611462
103Abnormality of the calcaneus (HP:0008364)1.93373738
104Abnormality of the renal collecting system (HP:0004742)1.93005167
105Increased density of long bones (HP:0006392)1.91974211
106Abnormality of the heme biosynthetic pathway (HP:0010472)1.91628410
107Uterine leiomyosarcoma (HP:0002891)1.91614497
108Leiomyosarcoma (HP:0100243)1.91614497
109Insomnia (HP:0100785)1.91612192
110Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.91445211
111Progressive external ophthalmoplegia (HP:0000590)1.90128790
112Intestinal polyp (HP:0005266)1.89841903
113Broad ribs (HP:0000885)1.87408467
114Abnormal number of erythroid precursors (HP:0012131)1.87165356
115Abnormality of the carotid arteries (HP:0005344)1.86762623
116Abnormality of cochlea (HP:0000375)1.85654820
117Fibrous tissue neoplasm (HP:0012316)1.85174393
118Abnormality of the 4th metacarpal (HP:0010012)1.84264661
119Patellar aplasia (HP:0006443)1.83534606
120Abnormal hand bone ossification (HP:0010660)1.82631918
121Ectopic kidney (HP:0000086)1.82346658
122Neoplasm of the small intestine (HP:0100833)1.81946386
123Hypergonadotropic hypogonadism (HP:0000815)1.81784470
124Abnormal number of incisors (HP:0011064)1.80284446
125Uterine neoplasm (HP:0010784)1.79863333
126Hemivertebrae (HP:0002937)1.79785241
127Poikiloderma (HP:0001029)1.79616568
128Vertebral arch anomaly (HP:0008438)1.79201937
129Large earlobe (HP:0009748)1.78326864
130Abnormality of the peritoneum (HP:0002585)1.77954362
131Asymmetry of the thorax (HP:0001555)1.77653084
132Abnormality of the duodenum (HP:0002246)1.77512621
133Ankle contracture (HP:0006466)1.77250961
134Absent radius (HP:0003974)1.76961645
135Hematochezia (HP:0002573)1.76813515
136Short phalanx of the thumb (HP:0009660)1.76562477
137Premature graying of hair (HP:0002216)1.76466436
138Cellular immunodeficiency (HP:0005374)1.76395524
139Deep philtrum (HP:0002002)1.75146052
140Sparse lateral eyebrow (HP:0005338)1.74660137
141Fibroma (HP:0010614)1.74108379
142Tracheoesophageal fistula (HP:0002575)1.73366840
143High anterior hairline (HP:0009890)1.72662130
144Abnormal foot bone ossification (HP:0010675)1.71694325
145Increased mean platelet volume (HP:0011877)1.70665796
146Ankyloglossia (HP:0010296)1.70411443
147Atresia of the external auditory canal (HP:0000413)1.70083251
148Skull defect (HP:0001362)1.69837171
149Duplicated collecting system (HP:0000081)1.69484130
150Cellulitis (HP:0100658)1.69100025
151Cutis marmorata (HP:0000965)1.68438482
152Neoplasm of the rectum (HP:0100743)1.68330414
153Bladder carcinoma (HP:0002862)1.67686955
154Bladder neoplasm (HP:0009725)1.67686955
155Neoplasm of the colon (HP:0100273)1.67115169
156Cerebral aneurysm (HP:0004944)1.66756401
157Abnormality of pyrimidine metabolism (HP:0004353)1.66524284

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.31033279
2ZAK6.04748756
3VRK13.32255394
4CDC73.20006539
5STK42.71717730
6RPS6KA52.59345193
7EEF2K2.33613124
8SCYL22.25509701
9PKN22.18875379
10WEE12.00875321
11NEK21.98932263
12MAP3K101.86940415
13CDK91.71213761
14SRPK11.64713451
15AURKB1.63442666
16PIM11.61819218
17BUB11.58401528
18MAP3K81.56735772
19CDK121.56544041
20RPS6KB21.55642299
21CHEK21.41157777
22PBK1.37911700
23NEK11.31175983
24SMG11.29243888
25TTK1.26448538
26DAPK31.23947334
27TTN1.19044906
28EPHA21.18445099
29EIF2AK11.16454872
30FLT31.09083873
31ATR1.07481686
32PASK1.07434370
33PLK11.00274589
34ACVR1B0.99611413
35PKN10.94969817
36AURKA0.93506260
37STK100.93287933
38MAP2K70.91279290
39CDK40.86012904
40DYRK30.85244361
41NME20.84709383
42CDK80.84360558
43GRK60.82359763
44BLK0.80958305
45MAP3K40.79244205
46FRK0.78160711
47PLK30.78089666
48ICK0.78067740
49MELK0.78008418
50TAF10.77357187
51CHEK10.75250254
52TSSK60.73907576
53MET0.72908603
54MST1R0.70453264
55ATM0.69234101
56LRRK20.67785579
57IRAK30.66790659
58CCNB10.66775954
59TGFBR10.66323190
60CDK60.64649472
61BRSK20.63374284
62MAP2K40.62682352
63TRIB30.62572064
64EIF2AK30.62200034
65BMX0.60340133
66CAMK1D0.60079716
67CDK20.60048162
68BRAF0.59745890
69STK160.58893313
70AKT20.58541876
71CDK70.57622629
72MAPK110.57399702
73STK30.56416909
74ALK0.55267301
75NEK90.52066027
76LATS10.51762522
77DYRK1B0.49705490
78FGFR20.47270114
79MAP2K30.46234411
80CSNK1D0.46134352
81CDK10.45075904
82PAK40.44891828
83PTK60.40796382
84KSR10.40042498
85PLK40.38566241
86MARK30.37873799
87PAK20.37624831
88CAMK40.35961016
89RPS6KA40.35843943
90MTOR0.35730308
91PAK10.34851719
92PIM20.34365857
93BRSK10.33319471
94JAK20.32501200
95FGR0.32472274
96CSNK1G10.32015241
97PRKAA10.31257833
98TESK20.31244577
99PRKDC0.30513128
100PDGFRA0.28306916
101CSNK1A1L0.28190506
102CSNK1G30.26986684
103PRPF4B0.26355003
104ROCK10.25476518
105RIPK10.24929507
106CAMKK20.24394577
107RPS6KB10.23715186
108EIF2AK20.22832530
109CSNK2A20.22784030
110ILK0.21964702
111BRD40.21750535
112ERBB40.19319623
113MAPK140.19191465
114RAF10.18744340
115PRKCQ0.18265131
116FGFR10.17681866
117AKT10.17398040
118MKNK10.16909499
119STK240.16686965
120CAMK1G0.16307591
121TRPM70.15393306
122CLK10.15230170
123BTK0.14768206
124FGFR30.12224381
125KDR0.12123872
126PRKCI0.11498656
127CSF1R0.11436912
128RET0.11302225
129MAP3K90.11091184
130RPS6KA10.10486434
131MAPKAPK50.09328049
132MAP3K20.08837025
133PDK20.08575740
134RPS6KC10.06423413
135RPS6KL10.06423413
136MAP2K20.05750921
137BMPR1B0.05274285

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.11858566
2* Viral carcinogenesis_Homo sapiens_hsa052033.24421310
3DNA replication_Homo sapiens_hsa030303.08406111
4Mismatch repair_Homo sapiens_hsa034302.73371320
5One carbon pool by folate_Homo sapiens_hsa006702.52187395
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.06203189
7Cell cycle_Homo sapiens_hsa041102.01342633
8* Systemic lupus erythematosus_Homo sapiens_hsa0532210.8704278
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85509700
10RNA transport_Homo sapiens_hsa030131.80176158
11Transcriptional misregulation in cancer_Homo sapiens_hsa052021.78088270
12Nucleotide excision repair_Homo sapiens_hsa034201.69291309
13Non-homologous end-joining_Homo sapiens_hsa034501.66671935
14Base excision repair_Homo sapiens_hsa034101.51166823
15Spliceosome_Homo sapiens_hsa030401.47738800
16Fanconi anemia pathway_Homo sapiens_hsa034601.45100318
17Ribosome_Homo sapiens_hsa030101.39529260
18Homologous recombination_Homo sapiens_hsa034401.38932345
19p53 signaling pathway_Homo sapiens_hsa041151.13081160
20mRNA surveillance pathway_Homo sapiens_hsa030151.06823916
21MicroRNAs in cancer_Homo sapiens_hsa052061.00484534
22Selenocompound metabolism_Homo sapiens_hsa004500.89478001
23Small cell lung cancer_Homo sapiens_hsa052220.85673400
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83533955
25Pyrimidine metabolism_Homo sapiens_hsa002400.82629598
26RNA degradation_Homo sapiens_hsa030180.74761243
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73212607
28Chronic myeloid leukemia_Homo sapiens_hsa052200.71406208
29RNA polymerase_Homo sapiens_hsa030200.67359222
30HTLV-I infection_Homo sapiens_hsa051660.65000990
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62115182
32Central carbon metabolism in cancer_Homo sapiens_hsa052300.59012919
33Oocyte meiosis_Homo sapiens_hsa041140.58714850
34Biosynthesis of amino acids_Homo sapiens_hsa012300.58326541
35Bladder cancer_Homo sapiens_hsa052190.58221957
36Non-small cell lung cancer_Homo sapiens_hsa052230.57987492
37Epstein-Barr virus infection_Homo sapiens_hsa051690.57470074
38Antigen processing and presentation_Homo sapiens_hsa046120.56212400
39mTOR signaling pathway_Homo sapiens_hsa041500.52831526
40Apoptosis_Homo sapiens_hsa042100.52783283
41Herpes simplex infection_Homo sapiens_hsa051680.52510378
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49858773
43Colorectal cancer_Homo sapiens_hsa052100.47342873
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43761917
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43206894
46N-Glycan biosynthesis_Homo sapiens_hsa005100.42173428
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40768358
48Hepatitis B_Homo sapiens_hsa051610.40683766
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38509046
50Pancreatic cancer_Homo sapiens_hsa052120.38132016
51Proteoglycans in cancer_Homo sapiens_hsa052050.37093100
52Galactose metabolism_Homo sapiens_hsa000520.35651830
53Fructose and mannose metabolism_Homo sapiens_hsa000510.35641145
54Legionellosis_Homo sapiens_hsa051340.34966755
55Lysine degradation_Homo sapiens_hsa003100.34816329
56Glioma_Homo sapiens_hsa052140.34623318
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34305980
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33578645
59Adherens junction_Homo sapiens_hsa045200.33438908
60TGF-beta signaling pathway_Homo sapiens_hsa043500.33126550
61Pentose phosphate pathway_Homo sapiens_hsa000300.32600814
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.31153836
63Renin-angiotensin system_Homo sapiens_hsa046140.31153278
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31086848
65Prostate cancer_Homo sapiens_hsa052150.31065285
66Vitamin B6 metabolism_Homo sapiens_hsa007500.30990931
67Hedgehog signaling pathway_Homo sapiens_hsa043400.30708640
68Thyroid cancer_Homo sapiens_hsa052160.30603081
69Primary immunodeficiency_Homo sapiens_hsa053400.29977789
70Melanoma_Homo sapiens_hsa052180.29688676
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.29296392
72Basal transcription factors_Homo sapiens_hsa030220.28763535
73Purine metabolism_Homo sapiens_hsa002300.28507955
74HIF-1 signaling pathway_Homo sapiens_hsa040660.27674796
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26866847
76FoxO signaling pathway_Homo sapiens_hsa040680.26813361
77Viral myocarditis_Homo sapiens_hsa054160.26751572
78Measles_Homo sapiens_hsa051620.26696839
79Arginine biosynthesis_Homo sapiens_hsa002200.26151756
80Proteasome_Homo sapiens_hsa030500.25904895
81Hippo signaling pathway_Homo sapiens_hsa043900.25512287
82Sulfur metabolism_Homo sapiens_hsa009200.25171719
83Focal adhesion_Homo sapiens_hsa045100.23537012
84Pyruvate metabolism_Homo sapiens_hsa006200.23361826
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23322641
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23044433
87Endometrial cancer_Homo sapiens_hsa052130.23042145
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.23004592
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22716678
90B cell receptor signaling pathway_Homo sapiens_hsa046620.22652184
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22628340
92Nitrogen metabolism_Homo sapiens_hsa009100.22373342
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.22331654
94Pathways in cancer_Homo sapiens_hsa052000.19491877
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19309631
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19179714
97Tight junction_Homo sapiens_hsa045300.18887473
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18752874
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18738491
100Carbon metabolism_Homo sapiens_hsa012000.18659641
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18025957
102Hematopoietic cell lineage_Homo sapiens_hsa046400.17467724
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.17146026
104ErbB signaling pathway_Homo sapiens_hsa040120.16434265
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.15778586
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15031627
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.14167052
108Influenza A_Homo sapiens_hsa051640.13611881
109Inositol phosphate metabolism_Homo sapiens_hsa005620.11523885
110Sulfur relay system_Homo sapiens_hsa041220.11481125
111Basal cell carcinoma_Homo sapiens_hsa052170.11475987
112Platelet activation_Homo sapiens_hsa046110.11372622
113AMPK signaling pathway_Homo sapiens_hsa041520.10862312
114Toxoplasmosis_Homo sapiens_hsa051450.10766329
115Notch signaling pathway_Homo sapiens_hsa043300.10680632
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10601565
117ECM-receptor interaction_Homo sapiens_hsa045120.10394129
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.09402829
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.08596458
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.08544789
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08531377
122Wnt signaling pathway_Homo sapiens_hsa043100.07284226
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07130058
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.05874011
125Acute myeloid leukemia_Homo sapiens_hsa052210.05355711
126Prolactin signaling pathway_Homo sapiens_hsa049170.04022214

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