HIST1H4D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome assembly (GO:0006335)8.34712116
2DNA replication-dependent nucleosome organization (GO:0034723)8.34712116
3organ or tissue specific immune response (GO:0002251)7.25218415
4regulation of histone H3-K9 methylation (GO:0051570)6.62558740
5chromatin assembly (GO:0031497)6.35890030
6nucleosome assembly (GO:0006334)5.95504667
7mitotic chromosome condensation (GO:0007076)5.71969037
8DNA unwinding involved in DNA replication (GO:0006268)5.71280448
9nuclear pore complex assembly (GO:0051292)5.63300568
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.61421791
11protein localization to kinetochore (GO:0034501)5.52356365
12nuclear pore organization (GO:0006999)5.42988250
13chromatin assembly or disassembly (GO:0006333)5.27386770
14nucleosome organization (GO:0034728)5.17017245
15protein-DNA complex assembly (GO:0065004)5.08059899
16CENP-A containing nucleosome assembly (GO:0034080)4.87043644
17chromatin remodeling at centromere (GO:0031055)4.84365712
18peptidyl-lysine dimethylation (GO:0018027)4.81754768
19sister chromatid segregation (GO:0000819)4.80969773
20protein localization to chromosome, centromeric region (GO:0071459)4.65974332
21protein-DNA complex subunit organization (GO:0071824)4.55850028
22DNA replication initiation (GO:0006270)4.37556554
23pore complex assembly (GO:0046931)4.35683585
24pre-miRNA processing (GO:0031054)4.30301228
25kinetochore organization (GO:0051383)4.26098761
26antibacterial humoral response (GO:0019731)4.25353581
27DNA replication-independent nucleosome organization (GO:0034724)4.24953545
28DNA replication-independent nucleosome assembly (GO:0006336)4.24953545
29DNA strand elongation involved in DNA replication (GO:0006271)4.24090025
30mitotic sister chromatid segregation (GO:0000070)4.19502253
31negative regulation of histone methylation (GO:0031061)4.08255088
32mitotic nuclear envelope disassembly (GO:0007077)4.06799585
33telomere maintenance via semi-conservative replication (GO:0032201)4.04971464
34mitotic recombination (GO:0006312)4.03679093
35innate immune response in mucosa (GO:0002227)4.03566104
36DNA strand elongation (GO:0022616)4.02464875
37antimicrobial humoral response (GO:0019730)3.96503826
38mitotic sister chromatid cohesion (GO:0007064)3.95267644
39DNA duplex unwinding (GO:0032508)3.90534533
40DNA geometric change (GO:0032392)3.90411977
41histone exchange (GO:0043486)3.90174715
42regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.88941019
43ribosomal small subunit assembly (GO:0000028)3.88195045
44V(D)J recombination (GO:0033151)3.86608805
45folic acid-containing compound biosynthetic process (GO:0009396)3.86249383
46membrane disassembly (GO:0030397)3.84806123
47nuclear envelope disassembly (GO:0051081)3.84806123
48regulation of gene silencing (GO:0060968)3.80809741
49chromosome condensation (GO:0030261)3.77960715
50protein K6-linked ubiquitination (GO:0085020)3.77040747
51negative regulation of DNA repair (GO:0045738)3.74775347
52telomere maintenance via recombination (GO:0000722)3.73028658
53positive regulation of chromosome segregation (GO:0051984)3.71094621
54IMP biosynthetic process (GO:0006188)3.69632305
55positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.68658583
56positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.68658583
57positive regulation of mitotic sister chromatid separation (GO:1901970)3.68658583
58dosage compensation (GO:0007549)3.66848925
59DNA topological change (GO:0006265)3.66796018
60double-strand break repair via nonhomologous end joining (GO:0006303)3.64618744
61non-recombinational repair (GO:0000726)3.64618744
62meiotic chromosome segregation (GO:0045132)3.61980864
63attachment of spindle microtubules to kinetochore (GO:0008608)3.61379791
64regulation of spindle organization (GO:0090224)3.60550554
65regulation of mammary gland epithelial cell proliferation (GO:0033599)3.58245406
66negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.56966975
67regulation of megakaryocyte differentiation (GO:0045652)3.55376061
68mitotic metaphase plate congression (GO:0007080)3.52557146
69regulation of centriole replication (GO:0046599)3.52250512
70negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.50966938
71translesion synthesis (GO:0019985)3.46211835
72histone lysine demethylation (GO:0070076)3.45798380
73regulation of DNA endoreduplication (GO:0032875)3.41873643
74metaphase plate congression (GO:0051310)3.40375944
75regulation of centrosome cycle (GO:0046605)3.39225666
76DNA conformation change (GO:0071103)3.35927001
77regulation of sister chromatid cohesion (GO:0007063)3.35822796
78nucleotide-excision repair, DNA gap filling (GO:0006297)3.34930228
79IMP metabolic process (GO:0046040)3.34451811
80telomere maintenance (GO:0000723)3.34136566
81DNA packaging (GO:0006323)3.33514122
82negative regulation of chromosome segregation (GO:0051985)3.31599654
83ATP-dependent chromatin remodeling (GO:0043044)3.31037773
84telomere organization (GO:0032200)3.30166765
85protein complex localization (GO:0031503)3.28126837
86regulation of helicase activity (GO:0051095)3.27534194
87regulation of chromosome segregation (GO:0051983)3.26207307
88spindle checkpoint (GO:0031577)3.25883515
89histone demethylation (GO:0016577)3.25610232
90viral transcription (GO:0019083)3.24814622
91regulation of mitotic spindle organization (GO:0060236)3.23737705
92positive regulation of histone methylation (GO:0031062)3.21816140
93translational termination (GO:0006415)3.21369889
94protein localization to chromosome (GO:0034502)3.20036485
95regulation of mitotic sister chromatid separation (GO:0010965)3.20023768
96regulation of sister chromatid segregation (GO:0033045)3.20023768
97postreplication repair (GO:0006301)3.19822905
98nucleosome disassembly (GO:0006337)3.17078458
99protein-DNA complex disassembly (GO:0032986)3.17078458
100regulation of mitotic metaphase/anaphase transition (GO:0030071)3.16001296
101chromosome segregation (GO:0007059)3.15254961
102establishment of chromosome localization (GO:0051303)3.15071320
103telomere maintenance via telomere lengthening (GO:0010833)3.13360075
104regulation of posttranscriptional gene silencing (GO:0060147)3.13123911
105regulation of gene silencing by miRNA (GO:0060964)3.13123911
106regulation of gene silencing by RNA (GO:0060966)3.13123911
107DNA synthesis involved in DNA repair (GO:0000731)3.12789134
108DNA replication checkpoint (GO:0000076)3.12694486
109negative regulation of mitotic sister chromatid separation (GO:2000816)3.11649267
110negative regulation of sister chromatid segregation (GO:0033046)3.11649267
111negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.11649267
112negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11649267
113negative regulation of mitotic sister chromatid segregation (GO:0033048)3.11649267
114kinetochore assembly (GO:0051382)3.09875067
115spindle assembly checkpoint (GO:0071173)3.09749677
116positive regulation of cell cycle checkpoint (GO:1901978)3.08440218
117regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.07251435
118regulation of centrosome duplication (GO:0010824)3.05025216
119mucosal immune response (GO:0002385)3.02820089
120nucleobase biosynthetic process (GO:0046112)3.02813420
121regulation of translational fidelity (GO:0006450)3.02662046
122regulation of RNA export from nucleus (GO:0046831)3.02508976
123mitotic spindle assembly checkpoint (GO:0007094)3.01920211
124regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.00492280
125maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99477900
126regulation of mitotic sister chromatid segregation (GO:0033047)2.97950276
127positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.96288576
128protein demethylation (GO:0006482)2.89412156
129protein dealkylation (GO:0008214)2.89412156
130mitotic spindle checkpoint (GO:0071174)2.87165744
131histone arginine methylation (GO:0034969)2.87005130
132defense response to Gram-positive bacterium (GO:0050830)2.82852316
133cellular protein complex localization (GO:0034629)2.81412613

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.45936119
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.70469578
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.36859865
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.98121850
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.41727746
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74866625
7* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.65582407
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.30635682
9* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.30049586
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.24429516
11* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05330451
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse14.4055251
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.99515108
14* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95713772
15EGR1_19374776_ChIP-ChIP_THP-1_Human1.92390524
16MYC_19030024_ChIP-ChIP_MESCs_Mouse1.88872768
17EGR1_23403033_ChIP-Seq_LIVER_Mouse1.77699773
18* SOX2_16153702_ChIP-ChIP_HESCs_Human1.76757122
19* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.70751404
20AR_21909140_ChIP-Seq_LNCAP_Human1.68367623
21MYC_19079543_ChIP-ChIP_MESCs_Mouse1.66699494
22SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.63334643
23ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58784833
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58062915
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.57318429
26IRF1_19129219_ChIP-ChIP_H3396_Human1.52649178
27SOX2_18555785_ChIP-Seq_MESCs_Mouse1.52543051
28HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49969157
29ELK1_19687146_ChIP-ChIP_HELA_Human1.45334940
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44155617
31* VDR_23849224_ChIP-Seq_CD4+_Human1.43557106
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42602632
33* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40078458
34* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38036571
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37404737
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.36314522
37* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34388923
38* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34175112
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30605815
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30143421
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25041304
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23825477
43HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21466890
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19264112
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18734612
46* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17802603
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17646267
48* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15950745
49MYC_22102868_ChIP-Seq_BL_Human1.12856576
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.12692780
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12463122
52* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11825104
53* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09997419
54XRN2_22483619_ChIP-Seq_HELA_Human1.08651184
55EST1_17652178_ChIP-ChIP_JURKAT_Human1.07770136
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07154273
57* NANOG_16153702_ChIP-ChIP_HESCs_Human1.06347491
58* FOXP3_21729870_ChIP-Seq_TREG_Human1.06316916
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05321882
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04739238
61* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02355518
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00922980
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00335616
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98150452
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97121837
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96361028
67* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.95522134
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94583747
69* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94212752
70STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94033075
71* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.91681606
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89384307
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88165961
74THAP11_20581084_ChIP-Seq_MESCs_Mouse0.87607534
75* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86672059
76GABP_17652178_ChIP-ChIP_JURKAT_Human0.85952773
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85142082
78ETS1_20019798_ChIP-Seq_JURKAT_Human0.83849084
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.83458601
80* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82141862
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.81206407
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.80884253
83CIITA_25753668_ChIP-Seq_RAJI_Human0.80864621
84* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.80785462
85ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.80335177
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80080477
87VDR_21846776_ChIP-Seq_THP-1_Human0.78831015
88TTF2_22483619_ChIP-Seq_HELA_Human0.77529008
89MYC_18940864_ChIP-ChIP_HL60_Human0.75556329
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.74137080
91GATA1_22025678_ChIP-Seq_K562_Human0.72907231
92SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.72624572
93KDM5A_27292631_Chip-Seq_BREAST_Human0.72581585
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.71944828
95SOX9_26525672_Chip-Seq_HEART_Mouse0.71726936
96RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.69949715
97* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.69620673
98PKCTHETA_26484144_Chip-Seq_BREAST_Human0.69514499
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.69041914
100DCP1A_22483619_ChIP-Seq_HELA_Human0.68433071
101TP63_19390658_ChIP-ChIP_HaCaT_Human0.66550274
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.66541038
103FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.66482183
104NANOG_21062744_ChIP-ChIP_HESCs_Human0.65355721
105GATA2_22383799_ChIP-Seq_G1ME_Mouse0.64080197
106SALL4_22934838_ChIP-ChIP_CD34+_Human0.63447042
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.63296722
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.62828593
109FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.58867659
110SOX17_20123909_ChIP-Seq_XEN_Mouse0.55987583
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.55720450
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.51894048
113* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.47944048
114* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.46384853
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.46192088
116AR_21572438_ChIP-Seq_LNCaP_Human0.45357887
117CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.44323220
118NOTCH1_21737748_ChIP-Seq_TLL_Human0.44042232
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.43513853
120POU3F2_20337985_ChIP-ChIP_501MEL_Human0.42313588
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.41414452
122* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.40123747
123NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.39928239
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.39466344

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.89797181
2MP0003693_abnormal_embryo_hatching3.94005872
3MP0003111_abnormal_nucleus_morphology3.88736850
4MP0003077_abnormal_cell_cycle3.66059043
5MP0010307_abnormal_tumor_latency3.53265428
6MP0008057_abnormal_DNA_replication3.38624253
7MP0004957_abnormal_blastocyst_morpholog3.23248085
8MP0010352_gastrointestinal_tract_polyps3.05188132
9MP0009697_abnormal_copulation2.90203848
10MP0008058_abnormal_DNA_repair2.51934686
11MP0003123_paternal_imprinting2.49190204
12MP0008007_abnormal_cellular_replicative2.41268498
13MP0003941_abnormal_skin_development2.33083663
14MP0002396_abnormal_hematopoietic_system2.25001931
15MP0003705_abnormal_hypodermis_morpholog2.24303157
16MP0006054_spinal_hemorrhage2.23000591
17MP0008932_abnormal_embryonic_tissue2.16409093
18MP0000350_abnormal_cell_proliferation2.13896515
19MP0001661_extended_life_span2.12403481
20MP0005623_abnormal_meninges_morphology2.11021449
21MP0005076_abnormal_cell_differentiation2.07583567
22MP0001730_embryonic_growth_arrest2.03847646
23MP0010234_abnormal_vibrissa_follicle2.00640568
24MP0003121_genomic_imprinting2.00619659
25MP0004808_abnormal_hematopoietic_stem1.99421960
26MP0004185_abnormal_adipocyte_glucose1.91799576
27MP0008877_abnormal_DNA_methylation1.81168086
28MP0000490_abnormal_crypts_of1.68465090
29MP0004197_abnormal_fetal_growth/weight/1.66906654
30MP0001293_anophthalmia1.60632770
31MP0002086_abnormal_extraembryonic_tissu1.60290464
32MP0001697_abnormal_embryo_size1.60171796
33MP0001672_abnormal_embryogenesis/_devel1.53502569
34MP0005380_embryogenesis_phenotype1.53502569
35MP0002166_altered_tumor_susceptibility1.52941528
36MP0002084_abnormal_developmental_patter1.50333905
37MP0002085_abnormal_embryonic_tissue1.48409452
38MP0002080_prenatal_lethality1.44146748
39MP0002019_abnormal_tumor_incidence1.40753775
40MP0000703_abnormal_thymus_morphology1.36895742
41MP0003984_embryonic_growth_retardation1.35845368
42MP0003786_premature_aging1.34612636
43MP0002088_abnormal_embryonic_growth/wei1.34250510
44MP0000537_abnormal_urethra_morphology1.31856717
45MP0002006_tumorigenesis1.29950698
46MP0002009_preneoplasia1.27180226
47MP0001849_ear_inflammation1.26783849
48MP0005083_abnormal_biliary_tract1.25821321
49MP0000313_abnormal_cell_death1.24271536
50MP0003937_abnormal_limbs/digits/tail_de1.23328715
51MP0010030_abnormal_orbit_morphology1.22505452
52MP0002095_abnormal_skin_pigmentation1.20973199
53MP0003890_abnormal_embryonic-extraembry1.19088083
54MP0003567_abnormal_fetal_cardiomyocyte1.17080496
55MP0002398_abnormal_bone_marrow1.16521965
56MP0002638_abnormal_pupillary_reflex1.13544793
57MP0002722_abnormal_immune_system1.12724420
58MP0002092_abnormal_eye_morphology1.11011919
59MP0001545_abnormal_hematopoietic_system1.07207924
60MP0005397_hematopoietic_system_phenotyp1.07207924
61MP0002877_abnormal_melanocyte_morpholog1.06805433
62MP0000358_abnormal_cell_content/1.06263937
63MP0000371_diluted_coat_color1.05730653
64MP0000569_abnormal_digit_pigmentation1.05669069
65MP0000372_irregular_coat_pigmentation1.05188346
66MP0001915_intracranial_hemorrhage1.05117862
67MP0000689_abnormal_spleen_morphology1.00946657
68MP0002075_abnormal_coat/hair_pigmentati1.00122610
69MP0001299_abnormal_eye_distance/0.99149694
70MP0006035_abnormal_mitochondrial_morpho0.97420055
71MP0002697_abnormal_eye_size0.96744500
72MP0000733_abnormal_muscle_development0.96539054
73MP0009703_decreased_birth_body0.94666078
74MP0005220_abnormal_exocrine_pancreas0.93744697
75MP0006072_abnormal_retinal_apoptosis0.93046897
76MP0003385_abnormal_body_wall0.93018516
77MP0008438_abnormal_cutaneous_collagen0.92072543
78MP0009053_abnormal_anal_canal0.91748218
79MP0003861_abnormal_nervous_system0.91535455
80MP0001346_abnormal_lacrimal_gland0.90233442
81MP0003718_maternal_effect0.89915775
82MP0003566_abnormal_cell_adhesion0.89761816
83MP0004233_abnormal_muscle_weight0.87554299
84MP0003656_abnormal_erythrocyte_physiolo0.87074985
85MP0002111_abnormal_tail_morphology0.86767448
86MP0005023_abnormal_wound_healing0.85405870
87MP0003300_gastrointestinal_ulcer0.84504242
88MP0010678_abnormal_skin_adnexa0.83773841
89MP0005187_abnormal_penis_morphology0.82313453
90MP0001286_abnormal_eye_development0.82145387
91MP0005408_hypopigmentation0.81944951
92MP0002429_abnormal_blood_cell0.81456160
93MP0004272_abnormal_basement_membrane0.80238949
94MP0003787_abnormal_imprinting0.79558383
95MP0009384_cardiac_valve_regurgitation0.78870928
96MP0002751_abnormal_autonomic_nervous0.78604627
97MP0004147_increased_porphyrin_level0.77398757
98MP0003763_abnormal_thymus_physiology0.77009280
99MP0001800_abnormal_humoral_immune0.76663169
100MP0002925_abnormal_cardiovascular_devel0.76018936
101MP0002233_abnormal_nose_morphology0.75533049
102MP0005171_absent_coat_pigmentation0.75073377
103MP0005621_abnormal_cell_physiology0.74502132
104MP0002160_abnormal_reproductive_system0.74438709
105MP0005384_cellular_phenotype0.72473992
106MP0000716_abnormal_immune_system0.71788955
107MP0001186_pigmentation_phenotype0.71545416
108MP0000428_abnormal_craniofacial_morphol0.70866130
109MP0000432_abnormal_head_morphology0.70726477
110MP0009672_abnormal_birth_weight0.68399834
111MP0008770_decreased_survivor_rate0.67581863
112MP0002163_abnormal_gland_morphology0.65910958
113MP0002452_abnormal_antigen_presenting0.64872658
114MP0000015_abnormal_ear_pigmentation0.64845553
115MP0003935_abnormal_craniofacial_develop0.64343046
116MP0001879_abnormal_lymphatic_vessel0.63314865
117MP0000377_abnormal_hair_follicle0.62455969
118MP0001835_abnormal_antigen_presentation0.62238363
119MP0001929_abnormal_gametogenesis0.62143315
120MP0004264_abnormal_extraembryonic_tissu0.61933519
121MP0009278_abnormal_bone_marrow0.61809494
122MP0000685_abnormal_immune_system0.61758755
123MP0003448_altered_tumor_morphology0.61332033
124MP0002210_abnormal_sex_determination0.61102990
125MP0005391_vision/eye_phenotype0.60809355
126MP0000383_abnormal_hair_follicle0.60587500
127MP0003119_abnormal_digestive_system0.60069653
128MP0001145_abnormal_male_reproductive0.59845055
129MP0002420_abnormal_adaptive_immunity0.59692494
130MP0000427_abnormal_hair_cycle0.59535228
131MP0002114_abnormal_axial_skeleton0.59437248
132MP0002282_abnormal_trachea_morphology0.59342514
133MP0000477_abnormal_intestine_morphology0.59137308

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)4.96265212
2IgA deficiency (HP:0002720)4.44173726
3Colitis (HP:0002583)4.07483965
4Chromsome breakage (HP:0040012)3.99480528
5Short 4th metacarpal (HP:0010044)3.93933859
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.93933859
7Reticulocytopenia (HP:0001896)3.89694442
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.84300045
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.61659387
10Abnormality of chromosome stability (HP:0003220)3.42792977
11Cutaneous melanoma (HP:0012056)3.40500406
12Colon cancer (HP:0003003)3.34918286
13Chronic hepatic failure (HP:0100626)3.26815454
14Impulsivity (HP:0100710)3.07892630
15Volvulus (HP:0002580)2.99262927
16Birth length less than 3rd percentile (HP:0003561)2.93075008
17Ependymoma (HP:0002888)2.93069563
18Medulloblastoma (HP:0002885)2.91770587
19Selective tooth agenesis (HP:0001592)2.90235163
20Agnosia (HP:0010524)2.86897102
21Rhinitis (HP:0012384)2.77051105
22Abnormality of cells of the erythroid lineage (HP:0012130)2.71495423
23Hepatoblastoma (HP:0002884)2.70742688
24Recurrent sinusitis (HP:0011108)2.68363539
25Rhabdomyosarcoma (HP:0002859)2.68144137
26Asymmetry of the thorax (HP:0001555)2.60393238
27Meckel diverticulum (HP:0002245)2.59318734
28Abnormality of the 4th metacarpal (HP:0010012)2.55855808
29Astrocytoma (HP:0009592)2.54876210
30Abnormality of the astrocytes (HP:0100707)2.54876210
31Skull defect (HP:0001362)2.51677074
32Duodenal stenosis (HP:0100867)2.49138603
33Small intestinal stenosis (HP:0012848)2.49138603
34Increased nuchal translucency (HP:0010880)2.48822121
35Myelodysplasia (HP:0002863)2.47016305
36Abnormality of the ileum (HP:0001549)2.46980395
37Abnormality of the labia minora (HP:0012880)2.44739658
3811 pairs of ribs (HP:0000878)2.42629505
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.41330878
40Abnormal number of erythroid precursors (HP:0012131)2.40315743
41Thyroiditis (HP:0100646)2.39946121
42Basal cell carcinoma (HP:0002671)2.37805437
43Cafe-au-lait spot (HP:0000957)2.37516079
44Prominent nose (HP:0000448)2.37118973
45Hypopigmentation of the fundus (HP:0007894)2.36862516
46Autoimmune hemolytic anemia (HP:0001890)2.36541137
47Biliary tract neoplasm (HP:0100574)2.34663507
48Abnormality of the fingertips (HP:0001211)2.33301763
49High anterior hairline (HP:0009890)2.33294062
50Renovascular hypertension (HP:0100817)2.31681893
51Abnormality of the preputium (HP:0100587)2.31300608
52High pitched voice (HP:0001620)2.30921261
53Embryonal neoplasm (HP:0002898)2.28583616
54Sandal gap (HP:0001852)2.27905363
55Facial cleft (HP:0002006)2.25436899
56Abnormal lung lobation (HP:0002101)2.24423540
57Deviation of the thumb (HP:0009603)2.23528016
58Neoplasm of the oral cavity (HP:0100649)2.23116693
59Ectopic kidney (HP:0000086)2.22544850
60Glioma (HP:0009733)2.22477355
61Cutaneous syndactyly (HP:0012725)2.21061284
62Neonatal hypoglycemia (HP:0001998)2.18678536
63Atresia of the external auditory canal (HP:0000413)2.18226482
64Abnormality of reticulocytes (HP:0004312)2.17606713
65Poikilocytosis (HP:0004447)2.16212500
66Subacute progressive viral hepatitis (HP:0006572)2.16064501
67Amaurosis fugax (HP:0100576)2.15483689
68Freckling (HP:0001480)2.15411135
69Proximal placement of thumb (HP:0009623)2.14232110
70Papillary thyroid carcinoma (HP:0002895)2.13982214
71Aplasia/Hypoplasia of the sacrum (HP:0008517)2.13724325
72Sloping forehead (HP:0000340)2.13598991
73Cutaneous finger syndactyly (HP:0010554)2.13059237
74Abnormality of the duodenum (HP:0002246)2.12839751
75Bifid tongue (HP:0010297)2.12829008
76Abnormality of the distal phalanx of the thumb (HP:0009617)2.11484878
77Absent frontal sinuses (HP:0002688)2.11359136
78Arteriovenous malformation (HP:0100026)2.10889084
79Pallor (HP:0000980)2.09128697
80Cortical dysplasia (HP:0002539)2.08294300
81Malignant gastrointestinal tract tumors (HP:0006749)2.07810707
82Gastrointestinal carcinoma (HP:0002672)2.07810707
83Thrombocytosis (HP:0001894)2.06813283
84Patellar aplasia (HP:0006443)2.06575141
85Absent thumb (HP:0009777)2.05640410
86Abnormal number of incisors (HP:0011064)2.03652177
87Macrocytic anemia (HP:0001972)2.03576694
88Abnormality of the carotid arteries (HP:0005344)1.99910761
89Hematochezia (HP:0002573)1.98652625
90Missing ribs (HP:0000921)1.96857528
91Nephroblastoma (Wilms tumor) (HP:0002667)1.96107986
92Hypoplasia of the thymus (HP:0000778)1.95202529
93Neoplasm of the pancreas (HP:0002894)1.94756427
94Occipital encephalocele (HP:0002085)1.93749274
95Squamous cell carcinoma (HP:0002860)1.93189198
96Rectal prolapse (HP:0002035)1.93071253
97Chronic bronchitis (HP:0004469)1.92992515
98Spastic diplegia (HP:0001264)1.92896247
99Ovarian neoplasm (HP:0100615)1.90618547
100Neoplasm of striated muscle (HP:0009728)1.90583137
101Aplasia/Hypoplasia of the patella (HP:0006498)1.90149362
102T lymphocytopenia (HP:0005403)1.89125462
103Deep philtrum (HP:0002002)1.88186562
104B lymphocytopenia (HP:0010976)1.87233205
105Acanthocytosis (HP:0001927)1.86947857
106Lymphoma (HP:0002665)1.86656439
107Hypochromic microcytic anemia (HP:0004840)1.85859620
108Neoplasm of the adrenal cortex (HP:0100641)1.85558499
109Abnormality of the heme biosynthetic pathway (HP:0010472)1.85145713
110Poikiloderma (HP:0001029)1.84720375
111Broad distal phalanx of finger (HP:0009836)1.83963779
112Verrucae (HP:0200043)1.83672492
113Papilloma (HP:0012740)1.83672492
114Abnormality of abdominal situs (HP:0011620)1.83069145
115Abdominal situs inversus (HP:0003363)1.83069145
116Microtia (HP:0008551)1.82754808
117Clubbing of toes (HP:0100760)1.82739104
118Anal stenosis (HP:0002025)1.82472376
119Long eyelashes (HP:0000527)1.80631930
120Cutis marmorata (HP:0000965)1.80233868
121Ankyloglossia (HP:0010296)1.79901923
122Orthostatic hypotension (HP:0001278)1.79843622
123Duplication of thumb phalanx (HP:0009942)1.79730267
124Embryonal renal neoplasm (HP:0011794)1.79326520
125Bell-shaped thorax (HP:0001591)1.78242531
126Absent radius (HP:0003974)1.77984756
127Aplasia/Hypoplasia of the sternum (HP:0006714)1.76711018
128Inflammation of the large intestine (HP:0002037)1.75854966
129Entropion (HP:0000621)1.75854332
130Neoplasm of the heart (HP:0100544)1.75216420
131Truncal obesity (HP:0001956)1.74412493
132Acute lymphatic leukemia (HP:0006721)1.74200873
133Ulnar bowing (HP:0003031)1.73836600
134Intestinal polyposis (HP:0200008)1.73726632
135Combined immunodeficiency (HP:0005387)1.73377806
136Neoplasm of the colon (HP:0100273)1.72898368
137Syringomyelia (HP:0003396)1.72250078
138Spinal cord lesions (HP:0100561)1.72250078
139Cellulitis (HP:0100658)1.71442161
140Abnormality of the parietal bone (HP:0002696)1.71378931
141Uterine leiomyosarcoma (HP:0002891)1.70959541
142Leiomyosarcoma (HP:0100243)1.70959541
143Neoplasm of the small intestine (HP:0100833)1.70876800
144Intellectual disability, moderate (HP:0002342)1.70648579
145Midline defect of the nose (HP:0004122)1.70009547
146Microvesicular hepatic steatosis (HP:0001414)1.69814256
147Abnormal biliary tract physiology (HP:0012439)1.68262035
148Bile duct proliferation (HP:0001408)1.68262035
149Broad ribs (HP:0000885)1.67032243
150Thyroid carcinoma (HP:0002890)1.66320216
151Rectal fistula (HP:0100590)1.65638772
152Rectovaginal fistula (HP:0000143)1.65638772
153Flat cornea (HP:0007720)1.64975965
154Nasal polyposis (HP:0100582)1.64322733
155Anteriorly placed anus (HP:0001545)1.62735215
156Breast carcinoma (HP:0003002)1.61301973
157Hyperacusis (HP:0010780)1.60600359

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK18.66243268
2ZAK5.85916829
3CDC73.66208591
4VRK13.53877791
5STK43.15045991
6RPS6KA52.61875554
7WEE12.41026187
8NEK22.31867005
9MAP3K102.28198110
10SCYL22.13966649
11BUB12.00166550
12SRPK11.84310906
13CDK91.80638939
14AURKB1.79370802
15EEF2K1.66750628
16PIM11.66505036
17MAP3K81.61999882
18RPS6KB21.55751844
19PKN21.52136579
20CHEK21.50132759
21SMG11.49070201
22ACVR1B1.45712018
23TAF11.45069214
24TTK1.35299565
25ATR1.32511248
26TRIB31.32414649
27NEK11.26659313
28PLK11.22897660
29CDK121.21096129
30DYRK31.12055667
31FLT31.10620703
32FRK1.08860088
33EIF2AK11.07766120
34BRSK21.03592787
35PLK30.99406344
36STK100.98698186
37GRK60.97776517
38CDK40.94755477
39EIF2AK30.92367158
40DAPK30.89999892
41PASK0.88493048
42AURKA0.87836795
43TTN0.87785124
44EPHA20.85463106
45ICK0.84927671
46CHEK10.82550659
47ATM0.81990269
48MELK0.81617104
49MAP3K40.81482542
50LRRK20.75371114
51PKN10.73063077
52CDK70.72719435
53NME20.71572568
54TSSK60.71038020
55NLK0.70872190
56PBK0.69861916
57CDK60.69334482
58DYRK1B0.69100075
59TGFBR10.69033129
60CDK20.66209757
61BRAF0.64192206
62FGFR20.63346839
63CAMK40.63205542
64STK30.63104710
65LATS10.59818845
66PLK40.59615993
67BRD40.59600360
68CSNK1G10.58856129
69EIF2AK20.58815611
70CCNB10.58353577
71RPS6KA40.57731036
72CAMK1D0.57109584
73CDK80.54953290
74CDK10.52595778
75MAP2K70.51932830
76AKT20.51618879
77CSNK1A1L0.46392804
78CSNK1G30.44878842
79BRSK10.44710767
80NEK90.43211421
81CSF1R0.39703152
82CASK0.39389476
83MET0.39173414
84CSNK1D0.38818427
85MAP2K40.38717083
86PAK40.38065930
87CAMK1G0.36785739
88MKNK10.35751884
89TESK20.34732290
90BTK0.34232100
91MAP3K60.33491949
92AKT30.33417422
93CLK10.33287294
94PRKDC0.32564630
95MTOR0.32446969
96NUAK10.31407960
97PRPF4B0.30917315
98MAPK110.30659508
99FGFR30.29106176
100RPS6KB10.28663285
101CAMKK20.28615341
102RET0.28541315
103CSNK2A20.27716014
104MARK30.27674850
105CSNK1G20.27429462
106KSR10.27355836
107MAPK140.25276421
108SGK20.24776996
109KDR0.24658563
110PAK10.24020762
111MAP4K10.23609610
112PRKAA10.23525838
113SGK30.23221521
114AKT10.22386225
115JAK20.21081458
116EPHA30.19800382
117STK160.19135594
118PTK60.18433112
119FGFR10.18072168
120ROCK10.17958573
121ILK0.16676732
122CHUK0.16446735
123PDGFRA0.16203149
124RPS6KL10.15696067
125RPS6KC10.15696067
126MAP2K30.15559596
127SGK2230.14418546
128SGK4940.14418546
129MKNK20.14401456
130PRKCQ0.14188742
131BMX0.14142146
132RPS6KA60.14041155
133MST1R0.13970375
134CSNK2A10.13680590
135LYN0.12930710

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050345.68323346
2DNA replication_Homo sapiens_hsa030303.55086021
3Mismatch repair_Homo sapiens_hsa034303.10712007
4* Viral carcinogenesis_Homo sapiens_hsa052033.05609629
5Non-homologous end-joining_Homo sapiens_hsa034502.31905200
6Cell cycle_Homo sapiens_hsa041102.24272979
7One carbon pool by folate_Homo sapiens_hsa006702.12020728
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.08956149
9* Systemic lupus erythematosus_Homo sapiens_hsa0532210.1317202
10Base excision repair_Homo sapiens_hsa034101.98091947
11Nucleotide excision repair_Homo sapiens_hsa034201.89517111
12Homologous recombination_Homo sapiens_hsa034401.87559123
13Transcriptional misregulation in cancer_Homo sapiens_hsa052021.86600010
14Ribosome_Homo sapiens_hsa030101.84189224
15RNA transport_Homo sapiens_hsa030131.83680812
16Spliceosome_Homo sapiens_hsa030401.77314131
17Fanconi anemia pathway_Homo sapiens_hsa034601.76661198
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59412362
19p53 signaling pathway_Homo sapiens_hsa041151.30308530
20Pyrimidine metabolism_Homo sapiens_hsa002401.12714364
21mRNA surveillance pathway_Homo sapiens_hsa030151.09338923
22MicroRNAs in cancer_Homo sapiens_hsa052061.03921724
23RNA polymerase_Homo sapiens_hsa030200.99934994
24RNA degradation_Homo sapiens_hsa030180.99849464
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87583314
26Small cell lung cancer_Homo sapiens_hsa052220.84232958
27HTLV-I infection_Homo sapiens_hsa051660.76467416
28Herpes simplex infection_Homo sapiens_hsa051680.74773854
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74094677
30Antigen processing and presentation_Homo sapiens_hsa046120.73703869
31Epstein-Barr virus infection_Homo sapiens_hsa051690.73162617
32Selenocompound metabolism_Homo sapiens_hsa004500.67943676
33Chronic myeloid leukemia_Homo sapiens_hsa052200.65749878
34Oocyte meiosis_Homo sapiens_hsa041140.64647017
35Proteasome_Homo sapiens_hsa030500.61819797
36Basal transcription factors_Homo sapiens_hsa030220.61187558
37Colorectal cancer_Homo sapiens_hsa052100.57782259
38Hepatitis B_Homo sapiens_hsa051610.53765222
39Non-small cell lung cancer_Homo sapiens_hsa052230.53064080
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52671701
41Apoptosis_Homo sapiens_hsa042100.49928479
42NF-kappa B signaling pathway_Homo sapiens_hsa040640.48383334
43Measles_Homo sapiens_hsa051620.46947768
44Legionellosis_Homo sapiens_hsa051340.45057149
45Hedgehog signaling pathway_Homo sapiens_hsa043400.45014529
46mTOR signaling pathway_Homo sapiens_hsa041500.44953759
47Renin-angiotensin system_Homo sapiens_hsa046140.44596393
48Vitamin B6 metabolism_Homo sapiens_hsa007500.44191801
49Purine metabolism_Homo sapiens_hsa002300.43954036
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41609519
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41117777
52Thyroid cancer_Homo sapiens_hsa052160.40224356
53B cell receptor signaling pathway_Homo sapiens_hsa046620.39836866
54ErbB signaling pathway_Homo sapiens_hsa040120.39759205
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.39643407
56TGF-beta signaling pathway_Homo sapiens_hsa043500.39494659
57Pancreatic cancer_Homo sapiens_hsa052120.39308030
58Primary immunodeficiency_Homo sapiens_hsa053400.39207350
59Prostate cancer_Homo sapiens_hsa052150.39192347
60Bladder cancer_Homo sapiens_hsa052190.38137138
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38119234
62Adherens junction_Homo sapiens_hsa045200.36843872
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36025873
64Hematopoietic cell lineage_Homo sapiens_hsa046400.35816734
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35010537
66FoxO signaling pathway_Homo sapiens_hsa040680.33840072
67Viral myocarditis_Homo sapiens_hsa054160.33569934
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32901038
69Lysine degradation_Homo sapiens_hsa003100.32740439
70Proteoglycans in cancer_Homo sapiens_hsa052050.32446639
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32391490
72Pentose phosphate pathway_Homo sapiens_hsa000300.32363538
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31146263
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28923274
75Basal cell carcinoma_Homo sapiens_hsa052170.28426167
76Influenza A_Homo sapiens_hsa051640.27970927
77Glioma_Homo sapiens_hsa052140.27937774
78Melanoma_Homo sapiens_hsa052180.27845663
79Hippo signaling pathway_Homo sapiens_hsa043900.27805140
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27482164
81Endometrial cancer_Homo sapiens_hsa052130.27422751
82Sulfur relay system_Homo sapiens_hsa041220.27172246
83Wnt signaling pathway_Homo sapiens_hsa043100.27150985
84Pathways in cancer_Homo sapiens_hsa052000.26610959
85Biosynthesis of amino acids_Homo sapiens_hsa012300.25291227
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.24283270
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.24144379
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24143420
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23784143
90HIF-1 signaling pathway_Homo sapiens_hsa040660.23368537
91Notch signaling pathway_Homo sapiens_hsa043300.22603263
92Leishmaniasis_Homo sapiens_hsa051400.21260784
93N-Glycan biosynthesis_Homo sapiens_hsa005100.20980911
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20376296
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20048526
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19436745
97Toxoplasmosis_Homo sapiens_hsa051450.19227100
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.18655534
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.17129396
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16035842
101Platelet activation_Homo sapiens_hsa046110.15672570
102Focal adhesion_Homo sapiens_hsa045100.14925178
103VEGF signaling pathway_Homo sapiens_hsa043700.14273763
104Prolactin signaling pathway_Homo sapiens_hsa049170.13285971
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.12483217
106Acute myeloid leukemia_Homo sapiens_hsa052210.12113430
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10875119
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.10398572
109Galactose metabolism_Homo sapiens_hsa000520.10258322
110Osteoclast differentiation_Homo sapiens_hsa043800.09221017
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.09167187
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.08997653
113Insulin signaling pathway_Homo sapiens_hsa049100.08263633
114Shigellosis_Homo sapiens_hsa051310.08237492
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.07531476
116TNF signaling pathway_Homo sapiens_hsa046680.07373729
117Carbon metabolism_Homo sapiens_hsa012000.07317821
118AMPK signaling pathway_Homo sapiens_hsa041520.06989577
119Inositol phosphate metabolism_Homo sapiens_hsa005620.06791628
120Tight junction_Homo sapiens_hsa045300.06156537
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.05973219
122Choline metabolism in cancer_Homo sapiens_hsa052310.05697453
123Renal cell carcinoma_Homo sapiens_hsa052110.05319088
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.02567673
125Type II diabetes mellitus_Homo sapiens_hsa049300.01999846
126Fatty acid biosynthesis_Homo sapiens_hsa000610.01971861
127Melanogenesis_Homo sapiens_hsa049160.01669869

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