HIST1H4E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mucosal immune response (GO:0002385)8.99706852
2antibacterial humoral response (GO:0019731)8.72717898
3nucleosome assembly (GO:0006334)8.41133543
4organ or tissue specific immune response (GO:0002251)8.10938666
5antimicrobial humoral response (GO:0019730)7.91848120
6nuclear pore complex assembly (GO:0051292)7.63618856
7chromatin assembly (GO:0031497)7.63265864
8protein-DNA complex assembly (GO:0065004)7.18893677
9nucleosome organization (GO:0034728)7.08374561
10nuclear pore organization (GO:0006999)6.79212625
11protein-DNA complex subunit organization (GO:0071824)6.23526063
12regulation of histone H3-K9 methylation (GO:0051570)6.21241262
13pore complex assembly (GO:0046931)5.68180580
14chromatin assembly or disassembly (GO:0006333)5.58393317
15DNA unwinding involved in DNA replication (GO:0006268)5.37829347
16negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)5.10276288
17DNA replication initiation (GO:0006270)4.44909134
18CENP-A containing nucleosome assembly (GO:0034080)4.28363156
19replicative senescence (GO:0090399)4.27128322
20sister chromatid segregation (GO:0000819)4.18426014
21regulation of megakaryocyte differentiation (GO:0045652)4.16868707
22DNA strand elongation involved in DNA replication (GO:0006271)4.12848811
23mitotic sister chromatid segregation (GO:0000070)4.10387467
24protein localization to chromosome, centromeric region (GO:0071459)4.10372909
25mitotic chromosome condensation (GO:0007076)4.08981231
26chromatin remodeling at centromere (GO:0031055)4.04920123
27DNA strand elongation (GO:0022616)4.03979412
28regulation of centrosome cycle (GO:0046605)3.85745390
29negative regulation of DNA repair (GO:0045738)3.85686564
30DNA duplex unwinding (GO:0032508)3.79749396
31regulation of sister chromatid cohesion (GO:0007063)3.78656557
32DNA geometric change (GO:0032392)3.69007705
33viral mRNA export from host cell nucleus (GO:0046784)3.66270098
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.65120512
35telomere maintenance via semi-conservative replication (GO:0032201)3.60513350
36mitotic nuclear envelope disassembly (GO:0007077)3.50316472
37regulation of centrosome duplication (GO:0010824)3.50006741
38somatic diversification of immune receptors via somatic mutation (GO:0002566)3.37800966
39somatic hypermutation of immunoglobulin genes (GO:0016446)3.37800966
40mitotic sister chromatid cohesion (GO:0007064)3.37296731
41regulation of gene silencing (GO:0060968)3.34776790
42histone lysine demethylation (GO:0070076)3.33736356
43telomere maintenance via recombination (GO:0000722)3.33577718
44peptidyl-lysine dimethylation (GO:0018027)3.32515555
45nuclear envelope disassembly (GO:0051081)3.32339708
46membrane disassembly (GO:0030397)3.32339708
47histone exchange (GO:0043486)3.32283063
48telomere organization (GO:0032200)3.32254143
49defense response to Gram-positive bacterium (GO:0050830)3.31289845
50telomere maintenance (GO:0000723)3.29281711
51mitotic recombination (GO:0006312)3.28626010
52positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.27099094
53positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.27099094
54positive regulation of mitotic sister chromatid separation (GO:1901970)3.27099094
55translesion synthesis (GO:0019985)3.22392433
56histone demethylation (GO:0016577)3.21366387
57double-strand break repair via nonhomologous end joining (GO:0006303)3.20151434
58non-recombinational repair (GO:0000726)3.20151434
59regulation of DNA damage checkpoint (GO:2000001)3.17120641
60positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.15982135
61DNA synthesis involved in DNA repair (GO:0000731)3.15849817
62regulation of chromosome segregation (GO:0051983)3.10038118
63regulation of translational fidelity (GO:0006450)3.09565466
64regulation of centriole replication (GO:0046599)3.07402540
65regulation of RNA export from nucleus (GO:0046831)3.06289460
66positive regulation of chromosome segregation (GO:0051984)3.03740148
67ATP-dependent chromatin remodeling (GO:0043044)3.03290866
68DNA conformation change (GO:0071103)3.02943977
69regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.01539970
70protein localization to kinetochore (GO:0034501)3.00966119
71regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.98300511
72DNA replication-independent nucleosome assembly (GO:0006336)2.96629686
73DNA replication-independent nucleosome organization (GO:0034724)2.96629686
74dorsal/ventral axis specification (GO:0009950)2.94124388
75maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93132960
76meiotic chromosome segregation (GO:0045132)2.92189908
77centrosome duplication (GO:0051298)2.81221307
78protein demethylation (GO:0006482)2.80987965
79protein dealkylation (GO:0008214)2.80987965
80positive regulation of cell cycle checkpoint (GO:1901978)2.80362023
81replication fork processing (GO:0031297)2.80056647
82telomere maintenance via telomere lengthening (GO:0010833)2.80030200
83regulation of sister chromatid segregation (GO:0033045)2.78289227
84regulation of mitotic sister chromatid separation (GO:0010965)2.78289227
85regulation of mitotic sister chromatid segregation (GO:0033047)2.78289227
86embryonic process involved in female pregnancy (GO:0060136)2.77928645
87regulation of mitotic metaphase/anaphase transition (GO:0030071)2.75091338
88regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.75091338
89kinetochore organization (GO:0051383)2.73275924
90mitochondrial DNA metabolic process (GO:0032042)2.72931032
91negative regulation of chromosome segregation (GO:0051985)2.72464770
92DNA topological change (GO:0006265)2.70670700
93V(D)J recombination (GO:0033151)2.68864793
94somatic recombination of immunoglobulin gene segments (GO:0016447)2.67502690
95labyrinthine layer development (GO:0060711)2.66565391
96regulation of double-strand break repair (GO:2000779)2.64854262
97nucleotide-excision repair, DNA gap filling (GO:0006297)2.61430001
98innate immune response in mucosa (GO:0002227)11.0030321
99DNA replication-dependent nucleosome organization (GO:0034723)10.0514466
100DNA replication-dependent nucleosome assembly (GO:0006335)10.0514466

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.91013203
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.16191079
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.12887231
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.31187348
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.27881456
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.03512569
7GATA1_22025678_ChIP-Seq_K562_Human2.76020526
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.52865178
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.42918539
10* SOX2_16153702_ChIP-ChIP_HESCs_Human2.38827721
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34801540
12RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.31961714
13* POU5F1_16153702_ChIP-ChIP_HESCs_Human2.22449805
14MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.18393809
15* E2F1_21310950_ChIP-Seq_MCF-7_Human2.13522097
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse17.5087655
17CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.70557118
18HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.70423146
19IRF1_19129219_ChIP-ChIP_H3396_Human1.66045137
20NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50343485
21ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48581154
22SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.46539849
23AR_21909140_ChIP-Seq_LNCAP_Human1.39601499
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35319269
25ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33593468
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.30273486
27HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29488768
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27299955
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25083643
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23792297
31* NANOG_16153702_ChIP-ChIP_HESCs_Human1.21725107
32VDR_23849224_ChIP-Seq_CD4+_Human1.13371486
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12697014
34* ELK1_19687146_ChIP-ChIP_HELA_Human1.10640049
35KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08946384
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08668186
37SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07742325
38ETS1_22383799_ChIP-Seq_G1ME_Mouse1.07618700
39TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02355738
40PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00305325
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00046245
42SOX2_18692474_ChIP-Seq_MESCs_Mouse0.99381925
43VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98680072
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98210717
45ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95849691
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92711164
47THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90923622
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.88630224
49STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87586700
50DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86456833
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85746193
52PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84891410
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84407148
54MYC_18940864_ChIP-ChIP_HL60_Human0.82944509
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.81637484
56EGR1_19374776_ChIP-ChIP_THP-1_Human0.79532941
57KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79153985
58SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.79093610
59CREB1_15753290_ChIP-ChIP_HEK293T_Human0.78153160
60CIITA_25753668_ChIP-Seq_RAJI_Human0.77793104
61SOX9_26525672_Chip-Seq_HEART_Mouse0.76936994
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.75662150
63NOTCH1_21737748_ChIP-Seq_TLL_Human0.74068800
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74058551
65XRN2_22483619_ChIP-Seq_HELA_Human0.72080082
66E2F1_18555785_ChIP-Seq_MESCs_Mouse0.71656906
67KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.71620457
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.70835519
69BRD4_27068464_Chip-Seq_AML-cells_Mouse0.69138296
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.68646072
71MYC_18358816_ChIP-ChIP_MESCs_Mouse0.67409284
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.66407139
73TCF3_18692474_ChIP-Seq_MESCs_Mouse0.65959555
74* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.65069749
75FOXP3_21729870_ChIP-Seq_TREG_Human0.64712384
76SALL4_22934838_ChIP-ChIP_CD34+_Human0.62788538
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.62786626
78FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.61663610
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.60419543
80DCP1A_22483619_ChIP-Seq_HELA_Human0.59771967
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.59703625
82SOX17_20123909_ChIP-Seq_XEN_Mouse0.58156789
83VDR_21846776_ChIP-Seq_THP-1_Human0.57593499
84NANOG_18555785_ChIP-Seq_MESCs_Mouse0.57447803
85MYC_19079543_ChIP-ChIP_MESCs_Mouse0.57065170
86MYCN_18555785_ChIP-Seq_MESCs_Mouse0.55536212
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.55031082
88MYC_22102868_ChIP-Seq_BL_Human0.54809775
89ZFX_18555785_ChIP-Seq_MESCs_Mouse0.51694856
90* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.50318071
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.49924648
92ETS1_20019798_ChIP-Seq_JURKAT_Human0.49173235
93EST1_17652178_ChIP-ChIP_JURKAT_Human0.48816214
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.48465586
95MAF_26560356_Chip-Seq_TH1_Human0.47095075
96TTF2_22483619_ChIP-Seq_HELA_Human0.46385611
97SALL1_21062744_ChIP-ChIP_HESCs_Human0.46265126
98CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.45616180
99CHD1_26751641_Chip-Seq_LNCaP_Human0.45548939
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.43259254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.60938875
2MP0010094_abnormal_chromosome_stability4.51408162
3MP0002009_preneoplasia4.38157874
4MP0003111_abnormal_nucleus_morphology3.85318087
5MP0003077_abnormal_cell_cycle3.63386079
6MP0003693_abnormal_embryo_hatching3.47629950
7MP0004957_abnormal_blastocyst_morpholog3.22100941
8MP0010352_gastrointestinal_tract_polyps3.17631333
9MP0009697_abnormal_copulation2.75158498
10MP0005645_abnormal_hypothalamus_physiol2.35736003
11MP0010234_abnormal_vibrissa_follicle2.32835823
12MP0000569_abnormal_digit_pigmentation2.27265615
13MP0002396_abnormal_hematopoietic_system2.26404851
14MP0002166_altered_tumor_susceptibility2.17274949
15MP0008058_abnormal_DNA_repair2.10604630
16MP0004147_increased_porphyrin_level2.07173092
17MP0005083_abnormal_biliary_tract1.99754435
18MP0005171_absent_coat_pigmentation1.98392094
19MP0008932_abnormal_embryonic_tissue1.96732035
20MP0010307_abnormal_tumor_latency1.87743773
21MP0001661_extended_life_span1.86463830
22MP0000537_abnormal_urethra_morphology1.80248659
23MP0008007_abnormal_cellular_replicative1.78609790
24MP0000350_abnormal_cell_proliferation1.75395057
25MP0004808_abnormal_hematopoietic_stem1.71915427
26MP0002006_tumorigenesis1.67716932
27MP0002697_abnormal_eye_size1.47326373
28MP0002086_abnormal_extraembryonic_tissu1.46891613
29MP0005076_abnormal_cell_differentiation1.38880552
30MP0001672_abnormal_embryogenesis/_devel1.34954763
31MP0005380_embryogenesis_phenotype1.34954763
32MP0002084_abnormal_developmental_patter1.32822122
33MP0002160_abnormal_reproductive_system1.31146082
34MP0003656_abnormal_erythrocyte_physiolo1.30669688
35MP0003984_embryonic_growth_retardation1.30644494
36MP0003937_abnormal_limbs/digits/tail_de1.28763330
37MP0001697_abnormal_embryo_size1.27218677
38MP0003786_premature_aging1.26476624
39MP0005187_abnormal_penis_morphology1.25401226
40MP0001730_embryonic_growth_arrest1.25016814
41MP0002088_abnormal_embryonic_growth/wei1.24970204
42MP0002080_prenatal_lethality1.24402567
43MP0000313_abnormal_cell_death1.23456390
44MP0003941_abnormal_skin_development1.22964770
45MP0000372_irregular_coat_pigmentation1.22711167
46MP0003890_abnormal_embryonic-extraembry1.17818819
47MP0005220_abnormal_exocrine_pancreas1.17377900
48MP0000358_abnormal_cell_content/1.17248676
49MP0004185_abnormal_adipocyte_glucose1.16618520
50MP0002092_abnormal_eye_morphology1.09534201
51MP0005623_abnormal_meninges_morphology1.09259056
52MP0003763_abnormal_thymus_physiology1.09212058
53MP0003718_maternal_effect1.08043517
54MP0006072_abnormal_retinal_apoptosis1.08012057
55MP0000428_abnormal_craniofacial_morphol1.07076588
56MP0005253_abnormal_eye_physiology1.05169193
57MP0010678_abnormal_skin_adnexa1.04149904
58MP0002085_abnormal_embryonic_tissue1.03940063
59MP0005391_vision/eye_phenotype1.01902825
60MP0002019_abnormal_tumor_incidence1.01047493
61MP0002111_abnormal_tail_morphology1.00164819
62MP0002138_abnormal_hepatobiliary_system0.96011429
63MP0000490_abnormal_crypts_of0.95144060
64MP0005647_abnormal_sex_gland0.95041476
65MP0006035_abnormal_mitochondrial_morpho0.92517076
66MP0004197_abnormal_fetal_growth/weight/0.92322684
67MP0001849_ear_inflammation0.88153129
68MP0001293_anophthalmia0.86438483
69MP0008770_decreased_survivor_rate0.85486561
70MP0003183_abnormal_peptide_metabolism0.85397349
71MP0000371_diluted_coat_color0.84929664
72MP0001915_intracranial_hemorrhage0.82323328
73MP0001286_abnormal_eye_development0.81890462
74MP0004134_abnormal_chest_morphology0.80142732
75MP0004233_abnormal_muscle_weight0.80068076
76MP0009046_muscle_twitch0.78591011
77MP0003385_abnormal_body_wall0.78566332
78MP0001348_abnormal_lacrimal_gland0.78036014
79MP0005384_cellular_phenotype0.74633258
80MP0000733_abnormal_muscle_development0.74335794
81MP0000383_abnormal_hair_follicle0.74158683
82MP0002877_abnormal_melanocyte_morpholog0.73873993
83MP0003221_abnormal_cardiomyocyte_apopto0.70801904
84MP0002398_abnormal_bone_marrow0.69524487
85MP0001929_abnormal_gametogenesis0.68034874
86MP0000685_abnormal_immune_system0.67531282
87MP0003315_abnormal_perineum_morphology0.67469006
88MP0002722_abnormal_immune_system0.67057934
89MP0005621_abnormal_cell_physiology0.66788904
90MP0000703_abnormal_thymus_morphology0.65974435
91MP0003699_abnormal_female_reproductive0.61869692
92MP0001145_abnormal_male_reproductive0.61615475
93MP0000747_muscle_weakness0.59177080
94MP0001879_abnormal_lymphatic_vessel0.58584143
95MP0001191_abnormal_skin_condition0.58249585
96MP0002210_abnormal_sex_determination0.57627136
97MP0000631_abnormal_neuroendocrine_gland0.56816456
98MP0005389_reproductive_system_phenotype0.54222951
99MP0003861_abnormal_nervous_system0.53492324
100MP0003935_abnormal_craniofacial_develop0.53350451

Predicted human phenotypes

RankGene SetZ-score
1IgA deficiency (HP:0002720)5.31606233
2IgM deficiency (HP:0002850)5.20908862
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.88853649
4Chromsome breakage (HP:0040012)4.39814978
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.87305680
6Short 4th metacarpal (HP:0010044)3.87305680
7Colitis (HP:0002583)3.65008841
8Medulloblastoma (HP:0002885)3.60622413
9Abnormality of chromosome stability (HP:0003220)3.23077550
10Oral leukoplakia (HP:0002745)3.03963344
11Squamous cell carcinoma (HP:0002860)3.03046804
12Abnormality of the carotid arteries (HP:0005344)2.92791306
13Aplasia/Hypoplasia of the uvula (HP:0010293)2.88052095
14Abnormality of the preputium (HP:0100587)2.81649238
15Acanthocytosis (HP:0001927)2.74170442
16Abnormality of the fingertips (HP:0001211)2.66872696
17Abnormality of the 4th metacarpal (HP:0010012)2.65941984
18Birth length less than 3rd percentile (HP:0003561)2.62930302
19Gastrointestinal stroma tumor (HP:0100723)2.59897555
20Poikilocytosis (HP:0004447)2.59328330
21Hypoplasia of the pons (HP:0012110)2.53302659
22Orthostatic hypotension (HP:0001278)2.50678959
23Abnormality of cells of the erythroid lineage (HP:0012130)2.50566132
24Abnormality of DNA repair (HP:0003254)2.49946912
25Basal cell carcinoma (HP:0002671)2.45924954
26Broad ribs (HP:0000885)2.40817850
27Clubbing of toes (HP:0100760)2.37819923
28Abnormality of the ileum (HP:0001549)2.34688442
29Abnormality of the pons (HP:0007361)2.33894585
30Papillary thyroid carcinoma (HP:0002895)2.32274773
31Insomnia (HP:0100785)2.30861724
32Meckel diverticulum (HP:0002245)2.30255526
33Neoplasm of the oral cavity (HP:0100649)2.28622639
34Subacute progressive viral hepatitis (HP:0006572)2.26668203
35Renovascular hypertension (HP:0100817)2.24022911
36Recurrent sinusitis (HP:0011108)2.20378680
37Chronic diarrhea (HP:0002028)2.19383741
38Cellulitis (HP:0100658)2.18348281
39Abnormal number of erythroid precursors (HP:0012131)2.14495765
40Abnormality of the parietal bone (HP:0002696)2.14150248
41Nephroblastoma (Wilms tumor) (HP:0002667)2.13886083
42Vertebral arch anomaly (HP:0008438)2.11147434
43Dry hair (HP:0011359)2.08724683
44Small intestinal stenosis (HP:0012848)2.08650796
45Duodenal stenosis (HP:0100867)2.08650796
46Dysmetric saccades (HP:0000641)2.07542811
47Microvesicular hepatic steatosis (HP:0001414)2.06509064
48Prominent nose (HP:0000448)2.05828522
4911 pairs of ribs (HP:0000878)2.05606493
50Sandal gap (HP:0001852)2.05286746
51Recurrent bronchitis (HP:0002837)2.05267963
52Uterine leiomyosarcoma (HP:0002891)2.04843708
53Leiomyosarcoma (HP:0100243)2.04843708
54Subcapsular cataract (HP:0000523)2.04693772
55Myelodysplasia (HP:0002863)2.01342063
56Embryonal renal neoplasm (HP:0011794)2.01166413
57Gastrointestinal carcinoma (HP:0002672)2.00964548
58Malignant gastrointestinal tract tumors (HP:0006749)2.00964548
59Abnormality of the astrocytes (HP:0100707)2.00837113
60Astrocytoma (HP:0009592)2.00837113
61Neoplasm of the heart (HP:0100544)2.00383520
62Cafe-au-lait spot (HP:0000957)1.98965643
63Posterior subcapsular cataract (HP:0007787)1.95958726
64Cerebellar dysplasia (HP:0007033)1.95953812
65Bladder neoplasm (HP:0009725)1.93548262
66Bladder carcinoma (HP:0002862)1.93548262
67Thyroiditis (HP:0100646)1.93305854
68Neoplasm of striated muscle (HP:0009728)1.92730850
69Duplicated collecting system (HP:0000081)1.92472013
70Short thumb (HP:0009778)1.91711374
71Hyperacusis (HP:0010780)1.91233530
72Erythema (HP:0010783)1.90452629
73Arteriovenous malformation (HP:0100026)1.89879187
74Lymphoma (HP:0002665)1.88332506
75Down-sloping shoulders (HP:0200021)1.87917791
76Ectopic kidney (HP:0000086)1.85282672
77Thyroid carcinoma (HP:0002890)1.84144090
78Missing ribs (HP:0000921)1.83703702
79Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.83214102
80Inflammation of the large intestine (HP:0002037)1.82948986
81Partial agenesis of the corpus callosum (HP:0001338)1.82738631
82Colon cancer (HP:0003003)1.81592359
83Ridged nail (HP:0001807)1.81375952
84Abnormality of pyrimidine metabolism (HP:0004353)1.79277308
85Abnormality of the distal phalanx of the thumb (HP:0009617)1.78622452
86Hamartoma (HP:0010566)1.77038490
87Viral hepatitis (HP:0006562)1.76791912
88Acute lymphatic leukemia (HP:0006721)1.76575260
89Reticulocytopenia (HP:0001896)1.76228142
90Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.74737682
91Sloping forehead (HP:0000340)1.74498490
92Carpal bone hypoplasia (HP:0001498)1.72658580
93Abnormality of the duodenum (HP:0002246)1.72322443
94Spinal muscular atrophy (HP:0007269)1.72276817
95Ependymoma (HP:0002888)1.71960110
96High anterior hairline (HP:0009890)1.71115650
97Deep philtrum (HP:0002002)1.70685312
98Entropion (HP:0000621)1.70233572
99Anal stenosis (HP:0002025)1.70081815
100Abnormality of the renal collecting system (HP:0004742)1.70023704

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK9.26232251
2TLK18.56857425
3VRK15.32505429
4RPS6KA53.24720453
5DAPK32.54281977
6STK42.29950435
7AURKA1.95554245
8CDC71.92461034
9EEF2K1.71566684
10PBK1.67621424
11SCYL21.63680588
12PIM11.54698411
13BUB11.48901765
14TAF11.48773505
15AURKB1.42604043
16CHEK21.40882323
17SMG11.26739057
18MAP3K41.25735566
19PKN11.13808182
20MAP2K71.07949394
21BRSK20.98909943
22MAP3K100.98302854
23TTK0.97358208
24AKT30.94907215
25ICK0.86181084
26CDK120.83887337
27BRD40.82114013
28MAP3K80.81262627
29CCNB10.79821913
30RPS6KB20.79190537
31ATR0.78803456
32BLK0.73638339
33SRPK10.71646589
34PRKAA10.70441367
35PIM20.69796082
36PLK40.66753961
37NEK90.65020886
38AKT20.59641900
39BRAF0.59329797
40EIF2AK30.57834340
41MELK0.55783288
42CHEK10.53867655
43CSNK1A1L0.53650408
44MAP2K40.52483341
45PLK10.52192686
46CSNK1G10.51723022
47CAMK1D0.50469574
48NEK10.49033935
49CDK60.48407639
50BTK0.44596726
51ATM0.43820197
52CSNK1G30.43661485
53WEE10.43035061
54RAF10.41986930
55NME20.40113709
56MAPK110.39951168
57EPHA30.36777284
58SGK20.36652634
59TRIB30.36434890
60CAMK40.35708232
61CDK20.34294579
62RET0.33178849
63STK160.32639200
64MKNK20.31541418
65CLK10.30103075
66CDK70.29837537
67JAK20.28653367
68CDK90.27397132
69RPS6KB10.27101128
70NEK20.26284594
71CDK10.25977775
72MET0.25367788
73MST1R0.25012144
74TSSK60.24225884
75CSNK1G20.23906501
76CAMK1G0.23311817
77CDK80.23233306
78MTOR0.22892736
79SGK30.22603962
80NEK60.22343761
81TRPM70.20901359
82PDK20.20012140
83MAPKAPK50.19806738
84SGK4940.19400637
85SGK2230.19400637
86MST40.19038574
87SGK10.18524396
88PRKCQ0.18521771
89STK30.17847000
90EIF2AK20.15724273
91SYK0.13005641
92RPS6KA30.12920015
93BMPR1B0.12595263
94GSK3B0.11600037
95MAPK140.11222323
96CDK40.10525756
97PRKCI0.10192879
98PLK30.09951755
99MAP3K20.08063147
100NLK0.07770621

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050348.41735142
2* Viral carcinogenesis_Homo sapiens_hsa052033.80274929
3DNA replication_Homo sapiens_hsa030302.24452908
4Transcriptional misregulation in cancer_Homo sapiens_hsa052022.06570899
5* Systemic lupus erythematosus_Homo sapiens_hsa0532211.7964048
6Mismatch repair_Homo sapiens_hsa034301.52426305
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44454452
8Cell cycle_Homo sapiens_hsa041101.32329874
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26237669
10Non-homologous end-joining_Homo sapiens_hsa034501.24425588
11Fanconi anemia pathway_Homo sapiens_hsa034601.21646301
12Nucleotide excision repair_Homo sapiens_hsa034201.13464801
13Homologous recombination_Homo sapiens_hsa034401.02982724
14p53 signaling pathway_Homo sapiens_hsa041150.94449312
15Selenocompound metabolism_Homo sapiens_hsa004500.79872775
16Intestinal immune network for IgA production_Homo sapiens_hsa046720.77594532
17RNA transport_Homo sapiens_hsa030130.67111094
18One carbon pool by folate_Homo sapiens_hsa006700.66342431
19Base excision repair_Homo sapiens_hsa034100.63500891
20Spliceosome_Homo sapiens_hsa030400.60167336
21B cell receptor signaling pathway_Homo sapiens_hsa046620.57823249
22Thyroid cancer_Homo sapiens_hsa052160.57086553
23Non-small cell lung cancer_Homo sapiens_hsa052230.56531280
24Colorectal cancer_Homo sapiens_hsa052100.54691388
25Primary immunodeficiency_Homo sapiens_hsa053400.53664727
26MicroRNAs in cancer_Homo sapiens_hsa052060.52121935
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51734125
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50173538
29Small cell lung cancer_Homo sapiens_hsa052220.48840345
30Chronic myeloid leukemia_Homo sapiens_hsa052200.47448395
31Ribosome_Homo sapiens_hsa030100.45937415
32Basal cell carcinoma_Homo sapiens_hsa052170.44487579
33HTLV-I infection_Homo sapiens_hsa051660.43667386
34Asthma_Homo sapiens_hsa053100.42821571
35Pyrimidine metabolism_Homo sapiens_hsa002400.42699642
36Glioma_Homo sapiens_hsa052140.42549851
37Endometrial cancer_Homo sapiens_hsa052130.41204499
38Pancreatic cancer_Homo sapiens_hsa052120.40272748
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39866308
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38506580
41Lysine degradation_Homo sapiens_hsa003100.36804515
42Central carbon metabolism in cancer_Homo sapiens_hsa052300.35112710
43Inositol phosphate metabolism_Homo sapiens_hsa005620.34881377
44Fatty acid biosynthesis_Homo sapiens_hsa000610.34490477
45Epstein-Barr virus infection_Homo sapiens_hsa051690.33726304
46ErbB signaling pathway_Homo sapiens_hsa040120.32903402
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32337157
48TGF-beta signaling pathway_Homo sapiens_hsa043500.31943544
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31545038
50Allograft rejection_Homo sapiens_hsa053300.30796447
51Autoimmune thyroid disease_Homo sapiens_hsa053200.30584787
52mRNA surveillance pathway_Homo sapiens_hsa030150.30444246
53Apoptosis_Homo sapiens_hsa042100.30317459
54Sulfur relay system_Homo sapiens_hsa041220.30080086
55Melanoma_Homo sapiens_hsa052180.30013680
56Biosynthesis of amino acids_Homo sapiens_hsa012300.29315214
57Oocyte meiosis_Homo sapiens_hsa041140.26756543
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26646613
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26591808
60Herpes simplex infection_Homo sapiens_hsa051680.26164628
61Prostate cancer_Homo sapiens_hsa052150.24913253
62N-Glycan biosynthesis_Homo sapiens_hsa005100.24611447
63Bladder cancer_Homo sapiens_hsa052190.24333513
64Viral myocarditis_Homo sapiens_hsa054160.24269002
65RNA polymerase_Homo sapiens_hsa030200.24167635
66Pentose phosphate pathway_Homo sapiens_hsa000300.24028652
67Hepatitis B_Homo sapiens_hsa051610.23534382
68Hippo signaling pathway_Homo sapiens_hsa043900.23341957
69Basal transcription factors_Homo sapiens_hsa030220.23165613
70Purine metabolism_Homo sapiens_hsa002300.23132905
71RNA degradation_Homo sapiens_hsa030180.22940443
72Hedgehog signaling pathway_Homo sapiens_hsa043400.22572542
73Graft-versus-host disease_Homo sapiens_hsa053320.21019676
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20789367
75Renin-angiotensin system_Homo sapiens_hsa046140.20601150
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.20153008
77Prolactin signaling pathway_Homo sapiens_hsa049170.16948359
78FoxO signaling pathway_Homo sapiens_hsa040680.16127406
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15268355
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.14768578
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.14211371
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.13655777
83mTOR signaling pathway_Homo sapiens_hsa041500.13354247
84Pathways in cancer_Homo sapiens_hsa052000.13250562
85HIF-1 signaling pathway_Homo sapiens_hsa040660.13127050
86Type II diabetes mellitus_Homo sapiens_hsa049300.13090909
87Type I diabetes mellitus_Homo sapiens_hsa049400.12984213
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12922218
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12852599
90Acute myeloid leukemia_Homo sapiens_hsa052210.12146109
91Adherens junction_Homo sapiens_hsa045200.10380970
92Wnt signaling pathway_Homo sapiens_hsa043100.09530943
93Carbon metabolism_Homo sapiens_hsa012000.08979584
94Vitamin B6 metabolism_Homo sapiens_hsa007500.08924602
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.08416036
96Influenza A_Homo sapiens_hsa051640.08315607
97Fructose and mannose metabolism_Homo sapiens_hsa000510.08303251
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.08124381
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.07758603
100Proteoglycans in cancer_Homo sapiens_hsa052050.06972839

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