HIST1H4F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin assembly (GO:0031497)8.59486353
2regulation of histone H3-K9 methylation (GO:0051570)8.26254670
3nucleosome assembly (GO:0006334)7.56477414
4peptidyl-lysine dimethylation (GO:0018027)6.90717148
5nucleosome organization (GO:0034728)6.48214080
6protein-DNA complex assembly (GO:0065004)6.31951318
7mitotic chromosome condensation (GO:0007076)6.21579941
8nuclear pore complex assembly (GO:0051292)6.15240357
9DNA unwinding involved in DNA replication (GO:0006268)6.13714714
10chromatin assembly or disassembly (GO:0006333)6.10655923
11antibacterial humoral response (GO:0019731)6.08012829
12nuclear pore organization (GO:0006999)5.96644070
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.75311608
14innate immune response in mucosa (GO:0002227)5.75117214
15antimicrobial humoral response (GO:0019730)5.65040711
16protein-DNA complex subunit organization (GO:0071824)5.60644905
17protein localization to kinetochore (GO:0034501)5.39276674
18sister chromatid segregation (GO:0000819)5.19356350
19cilium or flagellum-dependent cell motility (GO:0001539)5.14549250
20negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.02838575
21cilium movement (GO:0003341)4.88703226
22ventricular system development (GO:0021591)4.80619926
23pore complex assembly (GO:0046931)4.67928141
24intra-S DNA damage checkpoint (GO:0031573)4.66679952
25imidazole-containing compound metabolic process (GO:0052803)4.66649367
26negative regulation of histone methylation (GO:0031061)4.64601070
27axonemal dynein complex assembly (GO:0070286)4.63258497
28protein localization to chromosome, centromeric region (GO:0071459)4.57479190
29mitotic sister chromatid segregation (GO:0000070)4.44109136
30maturation of SSU-rRNA (GO:0030490)4.43382475
31mucosal immune response (GO:0002385)4.39822510
32folic acid-containing compound biosynthetic process (GO:0009396)4.38013826
33regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.33664224
34DNA duplex unwinding (GO:0032508)4.24648733
35DNA geometric change (GO:0032392)4.23891428
36regulation of gene silencing (GO:0060968)4.23252088
37CENP-A containing nucleosome assembly (GO:0034080)4.22029750
38chromatin remodeling at centromere (GO:0031055)4.21613634
39organ or tissue specific immune response (GO:0002251)4.17082500
40DNA replication initiation (GO:0006270)4.13525556
41negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.11667485
42chromosome condensation (GO:0030261)4.10659203
43positive regulation of chromosome segregation (GO:0051984)4.02604680
44dosage compensation (GO:0007549)3.96229501
45mitotic nuclear envelope disassembly (GO:0007077)3.94114655
46protein K6-linked ubiquitination (GO:0085020)3.94058035
47regulation of megakaryocyte differentiation (GO:0045652)3.93447928
48positive regulation of mitotic sister chromatid separation (GO:1901970)3.84935300
49positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.84935300
50positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.84935300
51IMP biosynthetic process (GO:0006188)3.83453768
52DNA strand elongation involved in DNA replication (GO:0006271)3.81917932
53positive regulation of histone methylation (GO:0031062)3.79098101
54nuclear envelope disassembly (GO:0051081)3.77119313
55membrane disassembly (GO:0030397)3.77119313
56mitotic sister chromatid cohesion (GO:0007064)3.76459917
57DNA replication-independent nucleosome assembly (GO:0006336)3.75729091
58DNA replication-independent nucleosome organization (GO:0034724)3.75729091
59translesion synthesis (GO:0019985)3.74447163
60histone H3-K9 demethylation (GO:0033169)3.69938370
61regulation of centriole replication (GO:0046599)3.69233103
62regulation of sister chromatid cohesion (GO:0007063)3.66305873
63regulation of translational fidelity (GO:0006450)3.64793395
64histone H3-K36 demethylation (GO:0070544)3.64245892
65DNA topological change (GO:0006265)3.64098661
66DNA strand elongation (GO:0022616)3.59359074
67mitotic recombination (GO:0006312)3.57164094
68DNA conformation change (GO:0071103)3.50353108
69G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.49356199
70telomere maintenance via semi-conservative replication (GO:0032201)3.46843566
71IMP metabolic process (GO:0046040)3.46504305
72histone exchange (GO:0043486)3.45472407
73DNA packaging (GO:0006323)3.45196598
74histone lysine demethylation (GO:0070076)3.44698229
75somatic hypermutation of immunoglobulin genes (GO:0016446)3.42321016
76somatic diversification of immune receptors via somatic mutation (GO:0002566)3.42321016
77regulation of gene silencing by RNA (GO:0060966)3.42314175
78regulation of posttranscriptional gene silencing (GO:0060147)3.42314175
79regulation of gene silencing by miRNA (GO:0060964)3.42314175
80regulation of centrosome cycle (GO:0046605)3.41853488
81motile cilium assembly (GO:0044458)3.38164899
82histone demethylation (GO:0016577)3.37288618
83regulation of RNA export from nucleus (GO:0046831)3.34599714
84postreplication repair (GO:0006301)3.33641127
85kinetochore organization (GO:0051383)3.27491186
86meiotic chromosome segregation (GO:0045132)3.26278916
87regulation of histone methylation (GO:0031060)3.24304928
88DNA synthesis involved in DNA repair (GO:0000731)3.23811898
89negative regulation of DNA repair (GO:0045738)3.21987004
90regulation of spindle organization (GO:0090224)3.21694986
91regulation of centrosome duplication (GO:0010824)3.20353422
92pre-miRNA processing (GO:0031054)3.18082971
93negative regulation of gene silencing (GO:0060969)3.17938787
94regulation of DNA endoreduplication (GO:0032875)3.17400745
95regulation of chromosome segregation (GO:0051983)3.16488410
96telomere maintenance via recombination (GO:0000722)3.14314847
97attachment of spindle microtubules to kinetochore (GO:0008608)3.11937184
98ribosomal small subunit assembly (GO:0000028)3.11594628
99epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.10057282
100biotin metabolic process (GO:0006768)3.09302126
101telomere maintenance (GO:0000723)3.09114683
102ATP-dependent chromatin remodeling (GO:0043044)3.08382677
103cellular hyperosmotic response (GO:0071474)3.07660715
104protein localization to chromosome (GO:0034502)3.05620259
105telomere organization (GO:0032200)3.04653220
106determination of adult lifespan (GO:0008340)3.03458428
107mitotic G1 DNA damage checkpoint (GO:0031571)3.00671149
108protein demethylation (GO:0006482)2.99273344
109protein dealkylation (GO:0008214)2.99273344
110nucleotide-excision repair, DNA gap filling (GO:0006297)2.98119670
111regulation of mitotic spindle organization (GO:0060236)2.96318490
112negative regulation of histone modification (GO:0031057)2.95547833
113chromosome segregation (GO:0007059)2.95003771
114regulation of ARF protein signal transduction (GO:0032012)2.94989759
115intraciliary transport (GO:0042073)2.94633012
116regulation of helicase activity (GO:0051095)2.94320854
117negative regulation of chromosome segregation (GO:0051985)2.93397706
118mitotic DNA integrity checkpoint (GO:0044774)2.93163331
119regulation of mammary gland epithelial cell proliferation (GO:0033599)2.91400613
120spindle checkpoint (GO:0031577)2.91132842
121negative regulation of mitotic sister chromatid segregation (GO:0033048)2.90350335
122negative regulation of mitotic sister chromatid separation (GO:2000816)2.90350335
123negative regulation of sister chromatid segregation (GO:0033046)2.90350335
124negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.90350335
125negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.90350335
126microtubule depolymerization (GO:0007019)2.90183568
127regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.89040559
128regulation of sister chromatid segregation (GO:0033045)2.87723385
129regulation of mitotic sister chromatid separation (GO:0010965)2.87723385
130regulation of mitotic sister chromatid segregation (GO:0033047)2.87723385
131negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.86404107
132peptidyl-lysine trimethylation (GO:0018023)2.85099735
133regulation of chromatin silencing (GO:0031935)2.84368090
134regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.80602815
135regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.79656207
136regulation of mitotic metaphase/anaphase transition (GO:0030071)2.79656207
137mitotic spindle assembly checkpoint (GO:0007094)2.79301120
138morphogenesis of an epithelial sheet (GO:0002011)2.78976533
139spindle assembly checkpoint (GO:0071173)2.73494655
140labyrinthine layer development (GO:0060711)2.67352647
141pteridine-containing compound biosynthetic process (GO:0042559)2.65891258
142somatic recombination of immunoglobulin gene segments (GO:0016447)2.64383502
143replicative senescence (GO:0090399)2.63232012
144tetrahydrofolate metabolic process (GO:0046653)2.63065085
145DNA replication-dependent nucleosome assembly (GO:0006335)10.0208973
146DNA replication-dependent nucleosome organization (GO:0034723)10.0208973

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.35037184
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.93355047
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.19377499
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.01778049
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.10309106
6* SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.02855447
7* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.36340021
8* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.27794636
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18889754
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.17134008
11* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.14034451
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse17.0587277
13* SOX2_16153702_ChIP-ChIP_HESCs_Human1.98162579
14E2F1_21310950_ChIP-Seq_MCF-7_Human1.97932440
15CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.85573073
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73783730
17SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.72090745
18* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.71363237
19GBX2_23144817_ChIP-Seq_PC3_Human1.67116731
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.65258003
21IRF1_19129219_ChIP-ChIP_H3396_Human1.62225542
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.58049773
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.56446690
24* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47997219
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47649791
26* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46521843
27SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46307322
28TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42858876
29HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.40592142
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39942739
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37121642
32* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33217891
33* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.31285803
34* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30956440
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29408267
36AR_21909140_ChIP-Seq_LNCAP_Human1.29361306
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26920646
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25705204
39* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22979435
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20990824
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20696770
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14610602
43* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12128507
44* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10319781
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.08793483
46* VDR_23849224_ChIP-Seq_CD4+_Human1.08209508
47* NANOG_16153702_ChIP-ChIP_HESCs_Human1.07649428
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05469426
49MYC_22102868_ChIP-Seq_BL_Human1.04720111
50ELK1_19687146_ChIP-ChIP_HELA_Human1.04527871
51* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04257927
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01765120
53TCF3_18692474_ChIP-Seq_MESCs_Mouse1.00849299
54STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98204058
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97844389
56VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94119372
57STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93822603
58BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93603412
59POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92726963
60PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89722881
61NANOG_18555785_ChIP-Seq_MESCs_Mouse0.89434232
62GATA1_22025678_ChIP-Seq_K562_Human0.88539007
63RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87596545
64SOX9_26525672_Chip-Seq_HEART_Mouse0.86964113
65FUS_26573619_Chip-Seq_HEK293_Human0.84116866
66ETS1_22383799_ChIP-Seq_G1ME_Mouse0.83894902
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.81679655
68ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81596509
69PADI4_21655091_ChIP-ChIP_MCF-7_Human0.81442321
70AR_21572438_ChIP-Seq_LNCaP_Human0.80883243
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.80119297
72FOXP3_21729870_ChIP-Seq_TREG_Human0.79302536
73VDR_21846776_ChIP-Seq_THP-1_Human0.78141201
74* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.77262164
75MYC_18358816_ChIP-ChIP_MESCs_Mouse0.76960259
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.76725533
77* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76280535
78LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75727094
79SCL_19346495_ChIP-Seq_HPC-7_Human0.73847496
80RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.72899815
81* SALL4_22934838_ChIP-ChIP_CD34+_Human0.72658918
82* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.69591168
83MYCN_18555785_ChIP-Seq_MESCs_Mouse0.68465845
84* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.68455720
85XRN2_22483619_ChIP-Seq_HELA_Human0.67090146
86ZFX_18555785_ChIP-Seq_MESCs_Mouse0.66563451
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.65357273
88THAP11_20581084_ChIP-Seq_MESCs_Mouse0.63866030
89IGF1R_20145208_ChIP-Seq_DFB_Human0.62994332
90NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.62585288
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.61934397
92HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.61714544
93GATA1_26923725_Chip-Seq_HPCs_Mouse0.61207880
94GATA2_22383799_ChIP-Seq_G1ME_Mouse0.60770417
95MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.60354540
96SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.58177426
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.57744782
98NANOG_21062744_ChIP-ChIP_HESCs_Human0.57470975
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.57306707
100KDM5A_27292631_Chip-Seq_BREAST_Human0.56885962
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.56699526
102TP53_16413492_ChIP-PET_HCT116_Human0.56218542
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.55090644
104MAF_26560356_Chip-Seq_TH1_Human0.54770597
105TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.54345338
106MYC_18940864_ChIP-ChIP_HL60_Human0.54345023
107CREB1_15753290_ChIP-ChIP_HEK293T_Human0.54120719
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.54008855
109* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.53749406
110CIITA_25753668_ChIP-Seq_RAJI_Human0.53471609
111UTX_26944678_Chip-Seq_JUKART_Human0.53225018
112TCF7_22412390_ChIP-Seq_EML_Mouse0.52570091
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.51936381
114HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.51317377
115GATA1_19941826_ChIP-Seq_K562_Human0.50470674
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.48910120
117FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.48866905
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.48591496
119KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.48493715
120STAT3_23295773_ChIP-Seq_U87_Human0.46950901
121* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.46827564
122LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.46456726
123IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.46264024
124* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.46244302
125PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.45917115
126P300_19829295_ChIP-Seq_ESCs_Human0.43747456
127E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.43500800
128NANOG_18692474_ChIP-Seq_MESCs_Mouse0.42691112
129SOX17_20123909_ChIP-Seq_XEN_Mouse0.42576850
130* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.42394597
131SMAD4_21799915_ChIP-Seq_A2780_Human0.42093847
132TCF4_23295773_ChIP-Seq_U87_Human0.41708430
133CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.39189841
134BRD4_25478319_ChIP-Seq_HGPS_Human0.38681991
135FLI1_27457419_Chip-Seq_LIVER_Mouse0.38497854
136CTNNB1_20460455_ChIP-Seq_HCT116_Human0.37060430
137GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.37059513
138TBX3_20139965_ChIP-Seq_ESCs_Mouse0.36934939

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.98653151
2MP0010307_abnormal_tumor_latency4.22505694
3MP0003111_abnormal_nucleus_morphology4.04865215
4MP0002653_abnormal_ependyma_morphology4.04216121
5MP0003941_abnormal_skin_development3.53008303
6MP0003077_abnormal_cell_cycle3.52658654
7MP0010352_gastrointestinal_tract_polyps3.31048976
8MP0003693_abnormal_embryo_hatching3.24495774
9MP0003705_abnormal_hypodermis_morpholog3.06862463
10MP0010234_abnormal_vibrissa_follicle3.04771689
11MP0009697_abnormal_copulation2.93629741
12MP0008057_abnormal_DNA_replication2.79073208
13MP0004957_abnormal_blastocyst_morpholog2.77313466
14MP0006054_spinal_hemorrhage2.29348906
15MP0005076_abnormal_cell_differentiation2.29224320
16MP0003123_paternal_imprinting2.20730463
17MP0010030_abnormal_orbit_morphology2.17908881
18MP0000350_abnormal_cell_proliferation2.17381791
19MP0001730_embryonic_growth_arrest2.14593419
20MP0003656_abnormal_erythrocyte_physiolo2.11830956
21MP0008058_abnormal_DNA_repair2.11745902
22MP0003121_genomic_imprinting2.07872633
23MP0008007_abnormal_cellular_replicative2.07785289
24MP0004808_abnormal_hematopoietic_stem1.98651631
25MP0005275_abnormal_skin_tensile1.92952956
26MP0001661_extended_life_span1.88918771
27MP0008932_abnormal_embryonic_tissue1.85156285
28MP0002282_abnormal_trachea_morphology1.83641886
29MP0004197_abnormal_fetal_growth/weight/1.78794163
30MP0002396_abnormal_hematopoietic_system1.78599956
31MP0002086_abnormal_extraembryonic_tissu1.71411886
32MP0002877_abnormal_melanocyte_morpholog1.69420751
33MP0000383_abnormal_hair_follicle1.65701283
34MP0002084_abnormal_developmental_patter1.61626695
35MP0008877_abnormal_DNA_methylation1.60848809
36MP0001697_abnormal_embryo_size1.60679521
37MP0000537_abnormal_urethra_morphology1.58691763
38MP0004147_increased_porphyrin_level1.55739531
39MP0001672_abnormal_embryogenesis/_devel1.54763452
40MP0005380_embryogenesis_phenotype1.54763452
41MP0000490_abnormal_crypts_of1.53106874
42MP0001485_abnormal_pinna_reflex1.53062925
43MP0002080_prenatal_lethality1.48881442
44MP0002085_abnormal_embryonic_tissue1.47887927
45MP0002166_altered_tumor_susceptibility1.42639070
46MP0002009_preneoplasia1.41309255
47MP0002019_abnormal_tumor_incidence1.40454281
48MP0000703_abnormal_thymus_morphology1.39930680
49MP0004272_abnormal_basement_membrane1.39167821
50MP0003879_abnormal_hair_cell1.39025096
51MP0005171_absent_coat_pigmentation1.37793887
52MP0006072_abnormal_retinal_apoptosis1.35907633
53MP0002254_reproductive_system_inflammat1.33928304
54MP0003984_embryonic_growth_retardation1.33759170
55MP0002088_abnormal_embryonic_growth/wei1.32523490
56MP0000358_abnormal_cell_content/1.32152356
57MP0000371_diluted_coat_color1.28620199
58MP0005645_abnormal_hypothalamus_physiol1.28522507
59MP0003787_abnormal_imprinting1.25844603
60MP0003300_gastrointestinal_ulcer1.25325787
61MP0006035_abnormal_mitochondrial_morpho1.23605460
62MP0002095_abnormal_skin_pigmentation1.23156154
63MP0000733_abnormal_muscle_development1.22948765
64MP0000569_abnormal_digit_pigmentation1.21019933
65MP0000313_abnormal_cell_death1.20276211
66MP0001293_anophthalmia1.19741482
67MP0002722_abnormal_immune_system1.16979414
68MP0002398_abnormal_bone_marrow1.14902572
69MP0003786_premature_aging1.14140726
70MP0002075_abnormal_coat/hair_pigmentati1.11554547
71MP0002092_abnormal_eye_morphology1.11351961
72MP0000689_abnormal_spleen_morphology1.10997427
73MP0005408_hypopigmentation1.10328692
74MP0002006_tumorigenesis1.10298585
75MP0000372_irregular_coat_pigmentation1.09648719
76MP0003566_abnormal_cell_adhesion1.08824389
77MP0003937_abnormal_limbs/digits/tail_de1.06656005
78MP0002697_abnormal_eye_size1.06350438
79MP0001299_abnormal_eye_distance/1.04244415
80MP0001915_intracranial_hemorrhage1.03898596
81MP0008770_decreased_survivor_rate1.02756227
82MP0002089_abnormal_postnatal_growth/wei1.02184461
83MP0010678_abnormal_skin_adnexa1.01535782
84MP0005023_abnormal_wound_healing1.00230516
85MP0001348_abnormal_lacrimal_gland0.99586630
86MP0009046_muscle_twitch0.98292197
87MP0009384_cardiac_valve_regurgitation0.97327094
88MP0003567_abnormal_fetal_cardiomyocyte0.96437823
89MP0000432_abnormal_head_morphology0.95733930
90MP0004264_abnormal_extraembryonic_tissu0.95175673
91MP0003890_abnormal_embryonic-extraembry0.94790444
92MP0003183_abnormal_peptide_metabolism0.94612424
93MP0002111_abnormal_tail_morphology0.92908486
94MP0005220_abnormal_exocrine_pancreas0.92593110
95MP0002233_abnormal_nose_morphology0.92378635
96MP0009703_decreased_birth_body0.90900523
97MP0004185_abnormal_adipocyte_glucose0.90225094
98MP0003763_abnormal_thymus_physiology0.89461957
99MP0008438_abnormal_cutaneous_collagen0.88671826
100MP0005083_abnormal_biliary_tract0.88208579
101MP0002138_abnormal_hepatobiliary_system0.87100215
102MP0005623_abnormal_meninges_morphology0.85717263
103MP0005621_abnormal_cell_physiology0.84323581
104MP0005391_vision/eye_phenotype0.83624599
105MP0003136_yellow_coat_color0.82461517
106MP0002429_abnormal_blood_cell0.79958201
107MP0005384_cellular_phenotype0.79324086
108MP0001545_abnormal_hematopoietic_system0.76767111
109MP0005397_hematopoietic_system_phenotyp0.76767111
110MP0001186_pigmentation_phenotype0.76553896
111MP0002925_abnormal_cardiovascular_devel0.76312201
112MP0003283_abnormal_digestive_organ0.76039408
113MP0000049_abnormal_middle_ear0.75923161
114MP0003091_abnormal_cell_migration0.75893551
115MP0009278_abnormal_bone_marrow0.75010468
116MP0001849_ear_inflammation0.74897182
117MP0000685_abnormal_immune_system0.74785300
118MP0001800_abnormal_humoral_immune0.73679758
119MP0009672_abnormal_birth_weight0.71344709
120MP0002133_abnormal_respiratory_system0.70681393
121MP0005388_respiratory_system_phenotype0.70681393
122MP0005503_abnormal_tendon_morphology0.70022985
123MP0002060_abnormal_skin_morphology0.69786771
124MP0003453_abnormal_keratinocyte_physiol0.69670190
125MP0002177_abnormal_outer_ear0.69427073
126MP0003303_peritoneal_inflammation0.68908812
127MP0004233_abnormal_muscle_weight0.68465510
128MP0003935_abnormal_craniofacial_develop0.66805736
129MP0003448_altered_tumor_morphology0.64115052
130MP0000428_abnormal_craniofacial_morphol0.63709341
131MP0003119_abnormal_digestive_system0.63594690
132MP0000716_abnormal_immune_system0.63028498
133MP0003385_abnormal_body_wall0.62528402
134MP0001286_abnormal_eye_development0.61866646
135MP0000477_abnormal_intestine_morphology0.61334155
136MP0003861_abnormal_nervous_system0.60126152
137MP0000015_abnormal_ear_pigmentation0.59948505
138MP0009333_abnormal_splenocyte_physiolog0.58280420

Predicted human phenotypes

RankGene SetZ-score
1Recurrent sinusitis (HP:0011108)6.84013548
2IgM deficiency (HP:0002850)5.93384666
3IgA deficiency (HP:0002720)5.43571598
4Chronic hepatic failure (HP:0100626)5.36512529
5Rhinitis (HP:0012384)5.27741392
6Abnormal ciliary motility (HP:0012262)5.10728231
7Abnormal respiratory motile cilium physiology (HP:0012261)5.02294979
8Chronic bronchitis (HP:0004469)4.72914057
9Nasal polyposis (HP:0100582)4.55445587
10Colitis (HP:0002583)4.37115318
11Occipital encephalocele (HP:0002085)4.08315835
12Bronchitis (HP:0012387)4.05556799
13Poikilocytosis (HP:0004447)3.96947136
14Cutaneous melanoma (HP:0012056)3.93631442
15Abnormality of the nasal mucosa (HP:0000433)3.89918584
16Gastrointestinal stroma tumor (HP:0100723)3.87985563
17Tubular atrophy (HP:0000092)3.66626056
18Recurrent bronchitis (HP:0002837)3.59248684
19Bronchiectasis (HP:0002110)3.57209489
20Autoimmune hemolytic anemia (HP:0001890)3.50729477
21Chromsome breakage (HP:0040012)3.39913744
22Dynein arm defect of respiratory motile cilia (HP:0012255)3.34403960
23Absent/shortened dynein arms (HP:0200106)3.34403960
24Abnormal biliary tract physiology (HP:0012439)3.34083576
25Bile duct proliferation (HP:0001408)3.34083576
26Chromosomal breakage induced by crosslinking agents (HP:0003221)3.29348622
27Recurrent otitis media (HP:0000403)3.29339918
28Hypochromic microcytic anemia (HP:0004840)3.27549043
29Reticulocytopenia (HP:0001896)3.27234023
30Acanthocytosis (HP:0001927)3.25201377
31Ependymoma (HP:0002888)3.24074649
32Chronic diarrhea (HP:0002028)3.16586682
33Bell-shaped thorax (HP:0001591)3.11616780
34Impulsivity (HP:0100710)3.04626748
35Abnormality of chromosome stability (HP:0003220)3.02187670
36Hypopigmentation of the fundus (HP:0007894)3.01887589
37Abnormality of the astrocytes (HP:0100707)2.93945234
38Astrocytoma (HP:0009592)2.93945234
39Abnormality of reticulocytes (HP:0004312)2.93049688
40Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.89612743
41Short 4th metacarpal (HP:0010044)2.89612743
42Subacute progressive viral hepatitis (HP:0006572)2.84107417
43Rhabdomyosarcoma (HP:0002859)2.83074152
44Medulloblastoma (HP:0002885)2.78367339
45Agnosia (HP:0010524)2.76044231
46Reticulocytosis (HP:0001923)2.73821000
47Volvulus (HP:0002580)2.71418446
48Cortical dysplasia (HP:0002539)2.57941461
49Basal cell carcinoma (HP:0002671)2.56108655
50Ulnar bowing (HP:0003031)2.55835533
51Sandal gap (HP:0001852)2.52569012
52Cafe-au-lait spot (HP:0000957)2.51548837
53Cutaneous syndactyly (HP:0012725)2.51227008
54Bifid tongue (HP:0010297)2.49745828
55Thyroiditis (HP:0100646)2.49108784
56Colon cancer (HP:0003003)2.47150747
57Absent frontal sinuses (HP:0002688)2.46600437
58Lymphopenia (HP:0001888)2.45009162
59Neoplasm of the heart (HP:0100544)2.43359888
60High pitched voice (HP:0001620)2.42237208
61Spastic diplegia (HP:0001264)2.42154653
62Verrucae (HP:0200043)2.41128278
63Papilloma (HP:0012740)2.41128278
64Glioma (HP:0009733)2.41104655
65Intellectual disability, moderate (HP:0002342)2.38654121
66Selective tooth agenesis (HP:0001592)2.38015791
67Freckling (HP:0001480)2.37723361
68Abnormality of the fingertips (HP:0001211)2.36666890
69Prominent nose (HP:0000448)2.33625172
70Biliary tract neoplasm (HP:0100574)2.33525720
71Anophthalmia (HP:0000528)2.27919787
72Cutaneous finger syndactyly (HP:0010554)2.27626451
73Abnormality of the labia minora (HP:0012880)2.27387467
74Neoplasm of the oral cavity (HP:0100649)2.26779212
75Inflammation of the large intestine (HP:0002037)2.25701275
76Abnormality of cells of the erythroid lineage (HP:0012130)2.23583606
77Abnormality of cells of the lymphoid lineage (HP:0012140)2.22351974
78Gastrointestinal carcinoma (HP:0002672)2.22183599
79Malignant gastrointestinal tract tumors (HP:0006749)2.22183599
80Increased nuchal translucency (HP:0010880)2.20172420
81Neoplasm of striated muscle (HP:0009728)2.13268876
82Abnormality of the heme biosynthetic pathway (HP:0010472)2.13108535
83Hyperglycinemia (HP:0002154)2.12020726
84Heterotopia (HP:0002282)2.09642539
85Myelodysplasia (HP:0002863)2.08464959
86Squamous cell carcinoma (HP:0002860)2.07617605
87Anteriorly placed anus (HP:0001545)2.07390217
88Pancreatic fibrosis (HP:0100732)2.06759054
89Deviation of the thumb (HP:0009603)2.06091694
90Birth length less than 3rd percentile (HP:0003561)2.05334767
91Facial cleft (HP:0002006)2.01759770
92Pancreatic islet-cell hyperplasia (HP:0004510)2.01136792
93Gastrointestinal inflammation (HP:0004386)2.01105528
94Amaurosis fugax (HP:0100576)2.00336281
95Vitreoretinal degeneration (HP:0000655)2.00296225
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.1783146
97Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.98979983
98Broad ribs (HP:0000885)1.98083303
9911 pairs of ribs (HP:0000878)1.97324779
100Small intestinal stenosis (HP:0012848)1.95936095
101Duodenal stenosis (HP:0100867)1.95936095
102Ovarian neoplasm (HP:0100615)1.95179244
103Proximal placement of thumb (HP:0009623)1.94943788
104Macrocytic anemia (HP:0001972)1.94641651
105Entropion (HP:0000621)1.94001892
106Abnormality of the 4th metacarpal (HP:0010012)1.93351125
107Spontaneous hematomas (HP:0007420)1.93319428
108Optic nerve coloboma (HP:0000588)1.93305769
109Cerebral aneurysm (HP:0004944)1.93203843
110T lymphocytopenia (HP:0005403)1.92162943
111Portal hypertension (HP:0001409)1.91979670
112Sloping forehead (HP:0000340)1.91337217
113Cellulitis (HP:0100658)1.90249520
114Aplasia/Hypoplasia of the uvula (HP:0010293)1.89899113
115Hypoplasia of the thymus (HP:0000778)1.89797150
116Nephroblastoma (Wilms tumor) (HP:0002667)1.89781394
117Poikiloderma (HP:0001029)1.89709820
118Renovascular hypertension (HP:0100817)1.89432312
119Conjunctival telangiectasia (HP:0000524)1.88169659
120Abnormality of the calcaneus (HP:0008364)1.87637675
121Abnormality of the renal cortex (HP:0011035)1.86324201
122Embryonal renal neoplasm (HP:0011794)1.85941837
123Missing ribs (HP:0000921)1.85888187
124Anal stenosis (HP:0002025)1.84548459
125Rectal fistula (HP:0100590)1.83911835
126Rectovaginal fistula (HP:0000143)1.83911835
127Hematochezia (HP:0002573)1.83281406
128Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.83139540
129Nephronophthisis (HP:0000090)1.83129391
130Abnormality of the carotid arteries (HP:0005344)1.82734188
131Polydipsia (HP:0001959)1.82396444
132Abnormal drinking behavior (HP:0030082)1.82396444
133Meckel diverticulum (HP:0002245)1.82283408
134Cutis marmorata (HP:0000965)1.81811938
135Intestinal polyposis (HP:0200008)1.81375762
136Hypoplasia of the pons (HP:0012110)1.77452864
137Abnormality of chromosome segregation (HP:0002916)1.76561597
138Abnormality of the hepatic vasculature (HP:0006707)1.76273062
139Intestinal polyp (HP:0005266)1.75764989
140Abnormality of the ileum (HP:0001549)1.74630168
141Abnormal number of erythroid precursors (HP:0012131)1.74388949
142Stenosis of the external auditory canal (HP:0000402)1.74145955
143Emphysema (HP:0002097)1.73983488
144Hypochromic anemia (HP:0001931)1.73550732
145Abnormality of B cell number (HP:0010975)1.73400164
146B lymphocytopenia (HP:0010976)1.73400164
147Hyperacusis (HP:0010780)1.73089551
148Combined immunodeficiency (HP:0005387)1.73025440
149Carpal bone hypoplasia (HP:0001498)1.72068443
150Abnormality of the peritoneum (HP:0002585)1.72040130
151Ectopic kidney (HP:0000086)1.71158925
152Abnormality of the preputium (HP:0100587)1.71064454
153Skull defect (HP:0001362)1.71020219
154Angiofibromas (HP:0010615)1.70640488
155Adenoma sebaceum (HP:0009720)1.70640488
156Fibrous tissue neoplasm (HP:0012316)1.70536528
157Thrombocytosis (HP:0001894)1.69839692
158Abnormality of T cell number (HP:0011839)1.68928338
159Truncal obesity (HP:0001956)1.68378365
160Ectopic anus (HP:0004397)1.68356307
161Spinal muscular atrophy (HP:0007269)1.65521543
162Intestinal fistula (HP:0100819)1.63584842
163True hermaphroditism (HP:0010459)1.62183742
164Abnormal respiratory motile cilium morphology (HP:0005938)1.59546620
165Abnormal respiratory epithelium morphology (HP:0012253)1.59546620
166Abnormality of the nasolacrimal system (HP:0000614)1.57648025
167Thoracolumbar scoliosis (HP:0002944)1.56129664
168Poor eye contact (HP:0000817)1.55725159
169Scanning speech (HP:0002168)1.55396020
170Down-sloping shoulders (HP:0200021)1.54878847
171Limb hypertonia (HP:0002509)1.54675837
172Enlarged kidneys (HP:0000105)1.54064376
173Abnormality of the lacrimal duct (HP:0011481)1.53526779
174Deformed sella turcica (HP:0002681)1.51251951
175Abnormality of the parietal bone (HP:0002696)1.49621072
176Midline defect of the nose (HP:0004122)1.49580899
177Vaginal fistula (HP:0004320)1.48623498
178Abnormality of the distal phalanx of the thumb (HP:0009617)1.48424070
179Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.47023265
180Abnormality of the pons (HP:0007361)1.46560670
181Deep philtrum (HP:0002002)1.46386813
182Lymphoma (HP:0002665)1.43513114
183Ankyloglossia (HP:0010296)1.43275950

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.90739681
2ZAK6.39266751
3VRK13.38431178
4STK43.13829831
5CDC73.00112558
6RPS6KA52.93616648
7MAP3K102.69439758
8EEF2K2.29222649
9CDK92.20753947
10PKN22.09373366
11SCYL22.02341750
12NEK21.84989527
13PIM11.63872170
14MAP3K81.54904034
15AURKB1.52296653
16RPS6KB21.48457814
17CHEK21.44464601
18TAF11.37837248
19WEE11.34204516
20BUB11.32262487
21SRPK11.30150086
22MAP3K41.23437821
23PKN11.21461482
24SMG11.20289436
25CDK121.18900509
26GRK61.16207831
27DAPK31.15003300
28NEK91.04268451
29TTK1.01740776
30TTN0.99833025
31ATR0.96555849
32MAP2K70.94065378
33TIE10.93614962
34FLT30.91735737
35PTK2B0.89872979
36PLK40.87685912
37CDK40.86476594
38FRK0.86404108
39NEK10.86256280
40AURKA0.84491532
41CAMK40.84163154
42EPHA20.84147020
43STK100.83121168
44PLK10.82615987
45DYRK30.82592443
46TRIB30.76595606
47OBSCN0.75997852
48FGFR20.69523656
49PASK0.69360105
50EIF2AK10.68837565
51MAPK150.68328335
52ACVR1B0.67620507
53MELK0.66702551
54DYRK1B0.66007966
55CAMK1D0.65662612
56ATM0.65546666
57CHEK10.65542442
58LRRK20.64367408
59PLK30.62676624
60CDK60.61934835
61CSNK1G10.59980266
62AKT20.59680581
63PBK0.59055487
64BTK0.57946962
65CDK20.55375660
66SGK20.55056387
67CCNB10.50657833
68MAP2K40.50560382
69EIF2AK30.48622974
70NLK0.47217112
71CSNK1D0.46669169
72MET0.46161042
73PTK60.44918714
74STK240.44593076
75STK38L0.43526046
76MST1R0.43245302
77NME20.42445852
78PRKAA10.42142732
79CDK10.41866375
80BRAF0.41814994
81KSR10.39823979
82KDR0.39794985
83JAK20.37883963
84SGK2230.37807305
85SGK4940.37807305
86STK30.36850525
87TSSK60.36560460
88CDK70.35767525
89CSNK1A1L0.35402942
90TGFBR10.34955178
91TEC0.33949215
92PIK3CG0.32950238
93MTOR0.32028653
94BMX0.31968737
95ALK0.31475242
96FGR0.31241094
97PRKDC0.30353266
98CSNK1G30.29915013
99SGK10.29837334
100PDGFRA0.29609306
101BRSK20.29373127
102EPHA30.29306885
103PRKCQ0.29184717
104BMPR1B0.28510418
105CLK10.28406846
106MAP3K60.27742992
107FGFR30.27488890
108CDK190.27382126
109AKT30.27133951
110MARK30.27026275
111ROCK10.26496231
112MST40.26040930
113PAK10.24333747
114NUAK10.23020532
115PAK40.22959993
116LATS10.22622854
117PAK20.22305687
118RPS6KB10.21691235
119CSNK1G20.21579235
120MAPK70.20848105
121MAPK140.20008523
122SYK0.19644188
123TRPM70.19275004
124AKT10.18393051
125BRSK10.17915484
126CAMK1G0.17324337
127RPS6KA40.16706093
128RET0.16620740
129CSF1R0.16464155
130EGFR0.16092999
131RIPK10.15087797
132FGFR10.15043983
133CSNK2A20.14401171
134MAP4K10.13413412
135EIF2AK20.12652339
136MAPK110.11858849
137RPS6KA30.11579855
138BRD40.11371459
139SGK30.10344594
140MAPKAPK30.10184923
141RAF10.09895163
142PDGFRB0.09095151

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.86743876
2* Viral carcinogenesis_Homo sapiens_hsa052033.38455092
3DNA replication_Homo sapiens_hsa030302.55975111
4Mismatch repair_Homo sapiens_hsa034302.17182632
5Transcriptional misregulation in cancer_Homo sapiens_hsa052022.02633140
6* Systemic lupus erythematosus_Homo sapiens_hsa0532212.0512777
7One carbon pool by folate_Homo sapiens_hsa006701.78900406
8Non-homologous end-joining_Homo sapiens_hsa034501.74751294
9Cell cycle_Homo sapiens_hsa041101.69352925
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38204029
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31337400
12Base excision repair_Homo sapiens_hsa034101.26379822
13RNA transport_Homo sapiens_hsa030131.26324890
14Nucleotide excision repair_Homo sapiens_hsa034201.24313032
15Fanconi anemia pathway_Homo sapiens_hsa034601.22737598
16Homologous recombination_Homo sapiens_hsa034401.09754694
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.03801255
18Spliceosome_Homo sapiens_hsa030400.96801632
19MicroRNAs in cancer_Homo sapiens_hsa052060.89648508
20Ribosome_Homo sapiens_hsa030100.87745882
21Basal cell carcinoma_Homo sapiens_hsa052170.86293671
22p53 signaling pathway_Homo sapiens_hsa041150.85253411
23mRNA surveillance pathway_Homo sapiens_hsa030150.82060255
24Small cell lung cancer_Homo sapiens_hsa052220.77581559
25Allograft rejection_Homo sapiens_hsa053300.75174863
26Hedgehog signaling pathway_Homo sapiens_hsa043400.74144221
27Asthma_Homo sapiens_hsa053100.71946725
28Autoimmune thyroid disease_Homo sapiens_hsa053200.70133080
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69441626
30Selenocompound metabolism_Homo sapiens_hsa004500.68062563
31Chronic myeloid leukemia_Homo sapiens_hsa052200.67807084
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64961347
33Non-small cell lung cancer_Homo sapiens_hsa052230.63280739
34HTLV-I infection_Homo sapiens_hsa051660.58114773
35Graft-versus-host disease_Homo sapiens_hsa053320.57973878
36mTOR signaling pathway_Homo sapiens_hsa041500.53357356
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53109249
38Central carbon metabolism in cancer_Homo sapiens_hsa052300.51817479
39Oocyte meiosis_Homo sapiens_hsa041140.49548016
40Type I diabetes mellitus_Homo sapiens_hsa049400.49430992
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49341919
42Pyrimidine metabolism_Homo sapiens_hsa002400.46420346
43RNA degradation_Homo sapiens_hsa030180.45602533
44Bladder cancer_Homo sapiens_hsa052190.44488854
45Lysine degradation_Homo sapiens_hsa003100.42647130
46Epstein-Barr virus infection_Homo sapiens_hsa051690.42322190
47Biosynthesis of amino acids_Homo sapiens_hsa012300.41886190
48Antigen processing and presentation_Homo sapiens_hsa046120.41397037
49Apoptosis_Homo sapiens_hsa042100.41092364
50Glioma_Homo sapiens_hsa052140.41008996
51B cell receptor signaling pathway_Homo sapiens_hsa046620.40562258
52Propanoate metabolism_Homo sapiens_hsa006400.39512834
53Colorectal cancer_Homo sapiens_hsa052100.38286322
54Vitamin B6 metabolism_Homo sapiens_hsa007500.38092628
55Hepatitis B_Homo sapiens_hsa051610.36949872
56Herpes simplex infection_Homo sapiens_hsa051680.36866516
57Pancreatic cancer_Homo sapiens_hsa052120.36157978
58Renin-angiotensin system_Homo sapiens_hsa046140.34147479
59Pentose phosphate pathway_Homo sapiens_hsa000300.29984836
60Dorso-ventral axis formation_Homo sapiens_hsa043200.29864923
61Proteoglycans in cancer_Homo sapiens_hsa052050.29262397
62Prostate cancer_Homo sapiens_hsa052150.28854255
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.28272059
64FoxO signaling pathway_Homo sapiens_hsa040680.28058175
65Huntingtons disease_Homo sapiens_hsa050160.27684908
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27331063
67ErbB signaling pathway_Homo sapiens_hsa040120.26568523
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26401598
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26053065
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25939759
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25798413
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25747749
73Measles_Homo sapiens_hsa051620.24168590
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23210759
75HIF-1 signaling pathway_Homo sapiens_hsa040660.22913916
76Wnt signaling pathway_Homo sapiens_hsa043100.22535733
77Endometrial cancer_Homo sapiens_hsa052130.22528501
78Nitrogen metabolism_Homo sapiens_hsa009100.22390402
79Melanoma_Homo sapiens_hsa052180.21981190
80Hematopoietic cell lineage_Homo sapiens_hsa046400.21971588
81Viral myocarditis_Homo sapiens_hsa054160.20139672
82Inositol phosphate metabolism_Homo sapiens_hsa005620.19740823
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19631311
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.19088154
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.18827959
86Focal adhesion_Homo sapiens_hsa045100.18411240
87Thyroid cancer_Homo sapiens_hsa052160.17796457
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17508212
89Adherens junction_Homo sapiens_hsa045200.17301755
90TGF-beta signaling pathway_Homo sapiens_hsa043500.16934437
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16715640
92Legionellosis_Homo sapiens_hsa051340.16626423
93Basal transcription factors_Homo sapiens_hsa030220.16227713
94Primary immunodeficiency_Homo sapiens_hsa053400.15694191
95Notch signaling pathway_Homo sapiens_hsa043300.15364570
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15283364
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14991061
98Platelet activation_Homo sapiens_hsa046110.14648904
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14556184
100Pathways in cancer_Homo sapiens_hsa052000.14378008
101RNA polymerase_Homo sapiens_hsa030200.14290857
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.13756553
103Leishmaniasis_Homo sapiens_hsa051400.12856190
104Hippo signaling pathway_Homo sapiens_hsa043900.11982073
105Gap junction_Homo sapiens_hsa045400.11901906
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.11826122
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.11493663
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.11492055
109AMPK signaling pathway_Homo sapiens_hsa041520.11465898
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.11334760
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.10678301
112Tight junction_Homo sapiens_hsa045300.10599021
113Influenza A_Homo sapiens_hsa051640.10190222
114Carbon metabolism_Homo sapiens_hsa012000.09161880
115Sulfur relay system_Homo sapiens_hsa041220.09131308
116Prolactin signaling pathway_Homo sapiens_hsa049170.08848002
117N-Glycan biosynthesis_Homo sapiens_hsa005100.08723885
118Purine metabolism_Homo sapiens_hsa002300.08714386
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.08363123
120Toxoplasmosis_Homo sapiens_hsa051450.08304279
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.07705694
122Osteoclast differentiation_Homo sapiens_hsa043800.07177221
123ECM-receptor interaction_Homo sapiens_hsa045120.06608587
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.06558875
125Insulin resistance_Homo sapiens_hsa049310.06197977
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.05494442

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