HIST1H4H

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin assembly (GO:0031497)9.25604812
2regulation of histone H3-K9 methylation (GO:0051570)8.71321277
3nucleosome assembly (GO:0006334)7.88096219
4antibacterial humoral response (GO:0019731)6.79868714
5nucleosome organization (GO:0034728)6.71309354
6protein-DNA complex assembly (GO:0065004)6.64196040
7innate immune response in mucosa (GO:0002227)6.49791084
8antimicrobial humoral response (GO:0019730)6.27344467
9chromatin assembly or disassembly (GO:0006333)6.26043978
10nuclear pore complex assembly (GO:0051292)6.10934385
11mitotic chromosome condensation (GO:0007076)6.05747958
12DNA unwinding involved in DNA replication (GO:0006268)6.01806889
13protein-DNA complex subunit organization (GO:0071824)5.85379372
14nuclear pore organization (GO:0006999)5.82952364
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.79760881
16mucosal immune response (GO:0002385)5.37200248
17regulation of megakaryocyte differentiation (GO:0045652)5.20303409
18protein localization to kinetochore (GO:0034501)5.07475155
19organ or tissue specific immune response (GO:0002251)5.06656370
20sister chromatid segregation (GO:0000819)5.01269115
21negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.75039135
22regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.73680220
23negative regulation of histone methylation (GO:0031061)4.72394484
24pore complex assembly (GO:0046931)4.64483345
25regulation of gene silencing (GO:0060968)4.42154084
26chromatin remodeling at centromere (GO:0031055)4.35421040
27CENP-A containing nucleosome assembly (GO:0034080)4.31820340
28defense response to Gram-positive bacterium (GO:0050830)4.25294044
29protein localization to chromosome, centromeric region (GO:0071459)4.23399479
30rRNA transcription (GO:0009303)4.21962459
31chromosome condensation (GO:0030261)4.13515904
32folic acid-containing compound biosynthetic process (GO:0009396)4.04130485
33mitotic sister chromatid segregation (GO:0000070)4.03949362
34negative regulation of B cell apoptotic process (GO:0002903)4.03050154
35positive regulation of histone methylation (GO:0031062)4.02719346
36regulation of RNA export from nucleus (GO:0046831)4.01637390
37regulation of centriole replication (GO:0046599)3.97990578
38histone lysine demethylation (GO:0070076)3.91853696
39regulation of posttranscriptional gene silencing (GO:0060147)3.90632444
40regulation of gene silencing by miRNA (GO:0060964)3.90632444
41regulation of gene silencing by RNA (GO:0060966)3.90632444
42protein K6-linked ubiquitination (GO:0085020)3.89974224
43DNA duplex unwinding (GO:0032508)3.89551180
44positive regulation of chromosome segregation (GO:0051984)3.88729485
45DNA geometric change (GO:0032392)3.88052025
46regulation of hematopoietic progenitor cell differentiation (GO:1901532)3.81760929
47DNA replication initiation (GO:0006270)3.80295958
48histone demethylation (GO:0016577)3.76680297
49DNA replication-independent nucleosome organization (GO:0034724)3.68945113
50DNA replication-independent nucleosome assembly (GO:0006336)3.68945113
51regulation of sister chromatid cohesion (GO:0007063)3.67432916
52dosage compensation (GO:0007549)3.65655375
53histone exchange (GO:0043486)3.65266091
54regulation of centrosome cycle (GO:0046605)3.64659542
55negative regulation of DNA repair (GO:0045738)3.63566911
56DNA topological change (GO:0006265)3.60763831
57regulation of centrosome duplication (GO:0010824)3.56892705
58fatty acid elongation (GO:0030497)3.54255586
59spindle assembly involved in mitosis (GO:0090307)3.53737272
60positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.51929038
61positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.51929038
62positive regulation of mitotic sister chromatid separation (GO:1901970)3.51929038
63positive regulation of histone H3-K4 methylation (GO:0051571)3.44829601
64mitochondrial DNA metabolic process (GO:0032042)3.43293971
65DNA packaging (GO:0006323)3.43058893
66mitotic nuclear envelope disassembly (GO:0007077)3.38297063
67regulation of histone methylation (GO:0031060)3.36108410
68regulation of translational fidelity (GO:0006450)3.35433112
69polyamine biosynthetic process (GO:0006596)3.34970834
70mitotic sister chromatid cohesion (GO:0007064)3.27509432
71translesion synthesis (GO:0019985)3.27031173
72protein demethylation (GO:0006482)3.26423710
73protein dealkylation (GO:0008214)3.26423710
74membrane disassembly (GO:0030397)3.26411252
75nuclear envelope disassembly (GO:0051081)3.26411252
76DNA conformation change (GO:0071103)3.25766135
77DNA strand elongation involved in DNA replication (GO:0006271)3.25358271
78IMP biosynthetic process (GO:0006188)3.23184280
79regulation of nucleobase-containing compound transport (GO:0032239)3.21967099
80regulation of memory T cell differentiation (GO:0043380)3.21725304
81mitotic recombination (GO:0006312)3.21431382
82mitochondrial DNA replication (GO:0006264)3.20850681
83regulation of spindle organization (GO:0090224)3.19743751
84regulation of mitotic spindle organization (GO:0060236)3.18841204
85regulation of chromosome segregation (GO:0051983)3.10099980
86microtubule depolymerization (GO:0007019)3.07305038
87negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.06184684
88negative regulation of T-helper cell differentiation (GO:0045623)3.06184684
89telomere maintenance via recombination (GO:0000722)3.03751160
90DNA strand elongation (GO:0022616)3.03399803
91ATP-dependent chromatin remodeling (GO:0043044)3.01864567
92kinetochore organization (GO:0051383)3.00761698
93mitotic G1 DNA damage checkpoint (GO:0031571)3.00745348
94microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.98845680
95IMP metabolic process (GO:0046040)2.98539015
96DNA synthesis involved in DNA repair (GO:0000731)2.97734206
97positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.96527414
98mRNA cleavage (GO:0006379)2.95089159
99mitotic DNA integrity checkpoint (GO:0044774)2.92726248
100response to UV-C (GO:0010225)2.92076781
101negative regulation of histone modification (GO:0031057)2.91370135
102regulation of B cell apoptotic process (GO:0002902)2.90873896
103postreplication repair (GO:0006301)2.89984648
104telomere maintenance via semi-conservative replication (GO:0032201)2.88899986
105germinal center formation (GO:0002467)2.88894109
106spindle checkpoint (GO:0031577)2.88529840
107establishment of mitotic spindle localization (GO:0040001)2.88383028
108protein localization to chromosome (GO:0034502)2.87908763
109telomere organization (GO:0032200)2.85687007
110negative regulation of chromatin modification (GO:1903309)2.85418804
111regulation of DNA endoreduplication (GO:0032875)2.82084073
112proline biosynthetic process (GO:0006561)2.81880491
113attachment of spindle microtubules to kinetochore (GO:0008608)2.80873461
114meiotic chromosome segregation (GO:0045132)2.80219512
115somatic hypermutation of immunoglobulin genes (GO:0016446)2.79550816
116somatic diversification of immune receptors via somatic mutation (GO:0002566)2.79550816
117maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.78469891
118antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.76550262
119regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.76384044
120telomere maintenance (GO:0000723)2.75780609
121replication fork processing (GO:0031297)2.75231273
122resolution of meiotic recombination intermediates (GO:0000712)2.74972599
123chromosome segregation (GO:0007059)2.74058047
124peptidyl-lysine dimethylation (GO:0018027)2.67414432
125regulation of Golgi to plasma membrane protein transport (GO:0042996)2.67163366
126antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.59927707
127replicative senescence (GO:0090399)2.57740102
128regulation of integrin activation (GO:0033623)2.55941353
129DNA replication checkpoint (GO:0000076)2.53894068
130telomere maintenance via telomere lengthening (GO:0010833)2.47184756
131regulation of DNA damage checkpoint (GO:2000001)2.43318721
132cellular protein complex localization (GO:0034629)2.42377102
133B cell mediated immunity (GO:0019724)2.41521154
134spliceosomal tri-snRNP complex assembly (GO:0000244)2.40214173
135negative regulation of peptidyl-lysine acetylation (GO:2000757)2.39874037
136definitive hemopoiesis (GO:0060216)2.36358070
137nucleotide-excision repair, DNA gap filling (GO:0006297)2.32141274
138regulation of germinal center formation (GO:0002634)2.28918115
139DNA replication-dependent nucleosome assembly (GO:0006335)10.6573424
140DNA replication-dependent nucleosome organization (GO:0034723)10.6573424

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.12160961
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.31255403
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.87753440
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.67982671
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.28788882
6* SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.13465433
7* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.38832482
8SOX2_16153702_ChIP-ChIP_HESCs_Human2.28404007
9* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26844966
10* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13263972
11* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.11191607
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse18.4674934
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99563681
14CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.89549180
15POU5F1_16153702_ChIP-ChIP_HESCs_Human1.85318202
16SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.83998087
17IRF1_19129219_ChIP-ChIP_H3396_Human1.78833251
18E2F1_21310950_ChIP-Seq_MCF-7_Human1.73421276
19SOX2_18555785_ChIP-Seq_MESCs_Mouse1.62354362
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60175996
21* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45648173
22* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.40066996
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.35196204
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34732904
25* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.32253771
26CIITA_25753668_ChIP-Seq_RAJI_Human1.32048865
27HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31076169
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28161780
29AR_21909140_ChIP-Seq_LNCAP_Human1.27129993
30NANOG_16153702_ChIP-ChIP_HESCs_Human1.25522710
31* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.24315062
32MYC_18555785_ChIP-Seq_MESCs_Mouse1.19857372
33* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19782463
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18627026
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17556975
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16716935
37TCF3_18692474_ChIP-Seq_MESCs_Mouse1.15509171
38* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.13099254
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12449118
40* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10343976
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.06810049
42POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06282432
43* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05275531
44* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05075669
45* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04425410
46* HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99872921
47VDR_23849224_ChIP-Seq_CD4+_Human0.96913761
48* THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94238864
49EST1_17652178_ChIP-ChIP_JURKAT_Human0.92600161
50EGR1_19374776_ChIP-ChIP_THP-1_Human0.91396381
51* ELK1_19687146_ChIP-ChIP_HELA_Human0.91093024
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88641927
53* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.88601862
54DCP1A_22483619_ChIP-Seq_HELA_Human0.88499768
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88165963
56* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86702439
57MAF_26560356_Chip-Seq_TH1_Human0.84713978
58STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84544053
59PADI4_21655091_ChIP-ChIP_MCF-7_Human0.82050461
60SCL_19346495_ChIP-Seq_HPC-7_Human0.80970596
61* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.80655906
62* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77458007
63NANOG_18555785_ChIP-Seq_MESCs_Mouse0.76306321
64* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.75531127
65ETS1_20019798_ChIP-Seq_JURKAT_Human0.75478170
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.73326803
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.72951818
68GABP_17652178_ChIP-ChIP_JURKAT_Human0.72422631
69POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.72222298
70TFEB_21752829_ChIP-Seq_HELA_Human0.71561809
71JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.70845700
72* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.70404686
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.70311141
74SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.69572703
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.68979429
76SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.68639347
77TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.68411064
78NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.67510809
79* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.67376559
80STAT4_19710469_ChIP-ChIP_TH1__Mouse0.67258659
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.67073903
82ELF1_17652178_ChIP-ChIP_JURKAT_Human0.66801013
83* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.65851446
84* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.65594434
85IRF8_22096565_ChIP-ChIP_GC-B_Human0.64227135
86KDM5A_27292631_Chip-Seq_BREAST_Human0.64161977
87* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.64095086
88GATA1_22383799_ChIP-Seq_G1ME_Mouse0.63380807
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.63180902
90* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.62310221
91* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.62136397
92GATA1_22025678_ChIP-Seq_K562_Human0.60541079
93PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.60485204
94GATA6_25053715_ChIP-Seq_YYC3_Human0.59506517
95* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.59399381
96MYB_26560356_Chip-Seq_TH1_Human0.59304807
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.56486179
98* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.55182851
99MYCN_18555785_ChIP-Seq_MESCs_Mouse0.54835720
100ZFX_18555785_ChIP-Seq_MESCs_Mouse0.53824404
101PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.53656536
102SALL4_22934838_ChIP-ChIP_CD34+_Human0.53494200
103* FOXP3_21729870_ChIP-Seq_TREG_Human0.53229983
104SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.52621666
105NANOG_21062744_ChIP-ChIP_HESCs_Human0.51739101
106MYC_18358816_ChIP-ChIP_MESCs_Mouse0.50810626
107NANOG_18692474_ChIP-Seq_MESCs_Mouse0.50527869
108HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.50450114
109XRN2_22483619_ChIP-Seq_HELA_Human0.50015527
110MYC_18940864_ChIP-ChIP_HL60_Human0.49455213
111* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.48218332
112* SOX17_20123909_ChIP-Seq_XEN_Mouse0.48159805
113CREB1_15753290_ChIP-ChIP_HEK293T_Human0.48005693
114PKCTHETA_26484144_Chip-Seq_BREAST_Human0.45176784
115NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.44338290
116MYC_22102868_ChIP-Seq_BL_Human0.42974670
117* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.42785677
118CLOCK_20551151_ChIP-Seq_293T_Human0.42433901
119GATA2_22383799_ChIP-Seq_G1ME_Mouse0.41376620
120ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.41037714
121VDR_21846776_ChIP-Seq_THP-1_Human0.39135956
122TCF3_18692474_ChIP-Seq_MEFs_Mouse0.37882139
123* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.36780367
124NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.36491488
125KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.36126443

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.26358920
2MP0010307_abnormal_tumor_latency4.08336829
3MP0002138_abnormal_hepatobiliary_system4.01546445
4MP0003111_abnormal_nucleus_morphology3.47436753
5MP0010234_abnormal_vibrissa_follicle3.43179053
6MP0003077_abnormal_cell_cycle3.22447546
7MP0003705_abnormal_hypodermis_morpholog3.16161816
8MP0004381_abnormal_hair_follicle2.81561358
9MP0010352_gastrointestinal_tract_polyps2.81557182
10MP0005464_abnormal_platelet_physiology2.76357423
11MP0008057_abnormal_DNA_replication2.75205773
12MP0001835_abnormal_antigen_presentation2.51785025
13MP0004957_abnormal_blastocyst_morpholog2.46465293
14MP0009697_abnormal_copulation2.41909970
15MP0006054_spinal_hemorrhage2.36241216
16MP0008932_abnormal_embryonic_tissue2.35112327
17MP0003693_abnormal_embryo_hatching2.34590412
18MP0002006_tumorigenesis2.31182014
19MP0003121_genomic_imprinting2.23584242
20MP0001730_embryonic_growth_arrest2.19941024
21MP0003123_paternal_imprinting2.18520191
22MP0000537_abnormal_urethra_morphology2.16675524
23MP0003937_abnormal_limbs/digits/tail_de2.06043020
24MP0000350_abnormal_cell_proliferation2.03130481
25MP0005083_abnormal_biliary_tract1.98805964
26MP0000685_abnormal_immune_system1.90448306
27MP0005623_abnormal_meninges_morphology1.89204181
28MP0004197_abnormal_fetal_growth/weight/1.87035700
29MP0002084_abnormal_developmental_patter1.86105253
30MP0005076_abnormal_cell_differentiation1.84525371
31MP0008007_abnormal_cellular_replicative1.73662748
32MP0008438_abnormal_cutaneous_collagen1.73353893
33MP0006072_abnormal_retinal_apoptosis1.70406086
34MP0002085_abnormal_embryonic_tissue1.68814076
35MP0010678_abnormal_skin_adnexa1.67913011
36MP0001293_anophthalmia1.66756855
37MP0008877_abnormal_DNA_methylation1.65034626
38MP0001697_abnormal_embryo_size1.63977394
39MP0008058_abnormal_DNA_repair1.62944185
40MP0005645_abnormal_hypothalamus_physiol1.62451522
41MP0002086_abnormal_extraembryonic_tissu1.60650212
42MP0004147_increased_porphyrin_level1.60246436
43MP0002697_abnormal_eye_size1.59939179
44MP0003656_abnormal_erythrocyte_physiolo1.58156771
45MP0003136_yellow_coat_color1.55792027
46MP0002092_abnormal_eye_morphology1.55227314
47MP0000465_gastrointestinal_hemorrhage1.54203521
48MP0003763_abnormal_thymus_physiology1.52132755
49MP0005380_embryogenesis_phenotype1.49485091
50MP0001672_abnormal_embryogenesis/_devel1.49485091
51MP0002009_preneoplasia1.48154135
52MP0005171_absent_coat_pigmentation1.47184502
53MP0002080_prenatal_lethality1.44800880
54MP0005075_abnormal_melanosome_morpholog1.43886991
55MP0002396_abnormal_hematopoietic_system1.41417354
56MP0002398_abnormal_bone_marrow1.40688120
57MP0000733_abnormal_muscle_development1.40034653
58MP0002877_abnormal_melanocyte_morpholog1.38810805
59MP0005220_abnormal_exocrine_pancreas1.37902827
60MP0003890_abnormal_embryonic-extraembry1.37721768
61MP0004947_skin_inflammation1.36824934
62MP0006035_abnormal_mitochondrial_morpho1.36124329
63MP0000358_abnormal_cell_content/1.34617091
64MP0004808_abnormal_hematopoietic_stem1.34348531
65MP0002111_abnormal_tail_morphology1.31953724
66MP0008004_abnormal_stomach_pH1.29262959
67MP0003984_embryonic_growth_retardation1.23149777
68MP0002088_abnormal_embryonic_growth/wei1.22603072
69MP0003950_abnormal_plasma_membrane1.21974751
70MP0003941_abnormal_skin_development1.21727464
71MP0001299_abnormal_eye_distance/1.19235386
72MP0004185_abnormal_adipocyte_glucose1.18427719
73MP0002722_abnormal_immune_system1.16204503
74MP0005167_abnormal_blood-brain_barrier1.13956631
75MP0001800_abnormal_humoral_immune1.13805763
76MP0005391_vision/eye_phenotype1.12210005
77MP0010030_abnormal_orbit_morphology1.11846065
78MP0001849_ear_inflammation1.11689344
79MP0003718_maternal_effect1.10956294
80MP0000689_abnormal_spleen_morphology1.10456877
81MP0009703_decreased_birth_body1.08555106
82MP0003806_abnormal_nucleotide_metabolis1.07279798
83MP0002019_abnormal_tumor_incidence1.06546695
84MP0003861_abnormal_nervous_system1.05138759
85MP0001286_abnormal_eye_development1.04253470
86MP0003786_premature_aging1.03810968
87MP0000490_abnormal_crypts_of1.03356882
88MP0005501_abnormal_skin_physiology1.03139467
89MP0003283_abnormal_digestive_organ1.02208319
90MP0000383_abnormal_hair_follicle1.01075146
91MP0000428_abnormal_craniofacial_morphol0.99115687
92MP0001727_abnormal_embryo_implantation0.98129174
93MP0003567_abnormal_fetal_cardiomyocyte0.97645158
94MP0005410_abnormal_fertilization0.97505112
95MP0005310_abnormal_salivary_gland0.96386685
96MP0003787_abnormal_imprinting0.95058164
97MP0002429_abnormal_blood_cell0.94413252
98MP0008770_decreased_survivor_rate0.92954169
99MP0000462_abnormal_digestive_system0.92749490
100MP0005647_abnormal_sex_gland0.92362902
101MP0005408_hypopigmentation0.92349136
102MP0000432_abnormal_head_morphology0.91503766
103MP0004233_abnormal_muscle_weight0.90839623
104MP0001915_intracranial_hemorrhage0.90380186
105MP0000313_abnormal_cell_death0.89458041
106MP0002925_abnormal_cardiovascular_devel0.88515160
107MP0002089_abnormal_postnatal_growth/wei0.87041470
108MP0000703_abnormal_thymus_morphology0.86046046
109MP0002095_abnormal_skin_pigmentation0.85397013
110MP0005023_abnormal_wound_healing0.84664779
111MP0002075_abnormal_coat/hair_pigmentati0.84614473
112MP0003453_abnormal_keratinocyte_physiol0.83944903
113MP0000716_abnormal_immune_system0.80797350
114MP0002210_abnormal_sex_determination0.79839835
115MP0003632_abnormal_nervous_system0.78909485
116MP0002166_altered_tumor_susceptibility0.78674285
117MP0002796_impaired_skin_barrier0.77719650
118MP0003566_abnormal_cell_adhesion0.77137334
119MP0000015_abnormal_ear_pigmentation0.77036203
120MP0005253_abnormal_eye_physiology0.76404895
121MP0008995_early_reproductive_senescence0.76396144
122MP0005671_abnormal_response_to0.76177417
123MP0004134_abnormal_chest_morphology0.76075549
124MP0005384_cellular_phenotype0.75365507
125MP0000372_irregular_coat_pigmentation0.75280019
126MP0001929_abnormal_gametogenesis0.75164122
127MP0002254_reproductive_system_inflammat0.74695675
128MP0000427_abnormal_hair_cycle0.74574658
129MP0000013_abnormal_adipose_tissue0.74518509
130MP0003935_abnormal_craniofacial_develop0.73886011
131MP0001216_abnormal_epidermal_layer0.73773975
132MP0005187_abnormal_penis_morphology0.72925067
133MP0004272_abnormal_basement_membrane0.72801758
134MP0002638_abnormal_pupillary_reflex0.72775366
135MP0003091_abnormal_cell_migration0.72384922
136MP0009672_abnormal_birth_weight0.72300200
137MP0000377_abnormal_hair_follicle0.72014029
138MP0005000_abnormal_immune_tolerance0.71031647
139MP0005621_abnormal_cell_physiology0.70890655
140MP0001661_extended_life_span0.69933350
141MP0002282_abnormal_trachea_morphology0.68661662
142MP0001873_stomach_inflammation0.68194793
143MP0009053_abnormal_anal_canal0.67795601
144MP0002452_abnormal_antigen_presenting0.67627092
145MP0001191_abnormal_skin_condition0.67607954
146MP0001145_abnormal_male_reproductive0.67094015
147MP0002160_abnormal_reproductive_system0.66024674
148MP0001958_emphysema0.65413714
149MP0009333_abnormal_splenocyte_physiolog0.63293007
150MP0000647_abnormal_sebaceous_gland0.62605045

Predicted human phenotypes

RankGene SetZ-score
1IgA deficiency (HP:0002720)4.74603819
2Abnormality of the fingertips (HP:0001211)4.60340314
3Large eyes (HP:0001090)4.55883120
4IgM deficiency (HP:0002850)3.92390302
5Increased mean platelet volume (HP:0011877)3.92171524
6Cutaneous melanoma (HP:0012056)3.77834491
7Clubbing of toes (HP:0100760)3.70535937
8Abnormal platelet volume (HP:0011876)3.70081288
9Petechiae (HP:0000967)3.66839969
10Hypochromic microcytic anemia (HP:0004840)3.60866607
11Prolonged bleeding time (HP:0003010)3.46678410
12Reduced subcutaneous adipose tissue (HP:0003758)3.43034884
13Poikilocytosis (HP:0004447)3.32520715
14Hypopigmentation of the fundus (HP:0007894)3.27721499
153-Methylglutaconic aciduria (HP:0003535)3.21085852
16Acanthocytosis (HP:0001927)3.18067555
17Abnormality of alanine metabolism (HP:0010916)3.13402263
18Hyperalaninemia (HP:0003348)3.13402263
19Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.13402263
20Menorrhagia (HP:0000132)3.12709738
21Gastrointestinal stroma tumor (HP:0100723)3.12591548
22Abnormality of the preputium (HP:0100587)3.08359554
23Short 4th metacarpal (HP:0010044)3.04259783
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.04259783
25Aplasia/Hypoplasia of the uvula (HP:0010293)3.02162807
26Impulsivity (HP:0100710)2.97894430
27Astrocytoma (HP:0009592)2.97472323
28Abnormality of the astrocytes (HP:0100707)2.97472323
29Ulnar bowing (HP:0003031)2.93968537
30Elevated erythrocyte sedimentation rate (HP:0003565)2.89573098
31Chronic otitis media (HP:0000389)2.86316334
32Erythema (HP:0010783)2.80817004
33Colitis (HP:0002583)2.79906402
34Ependymoma (HP:0002888)2.77728661
35Recurrent bronchitis (HP:0002837)2.77350805
36Cortical dysplasia (HP:0002539)2.76846319
37Volvulus (HP:0002580)2.76395226
38Myelodysplasia (HP:0002863)2.65245163
39Spastic diplegia (HP:0001264)2.65204232
40Chromsome breakage (HP:0040012)2.63727754
41Abnormality of the carotid arteries (HP:0005344)2.63520222
42Spontaneous hematomas (HP:0007420)2.63415731
43Reticulocytopenia (HP:0001896)2.62420566
44Meckel diverticulum (HP:0002245)2.62164530
45Abnormality of the ileum (HP:0001549)2.62038763
46Abnormality of chromosome stability (HP:0003220)2.60755803
47Leiomyosarcoma (HP:0100243)2.59179787
48Uterine leiomyosarcoma (HP:0002891)2.59179787
49Abnormal platelet function (HP:0011869)2.58268896
50Impaired platelet aggregation (HP:0003540)2.58268896
51Sandal gap (HP:0001852)2.53258877
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.52732412
53Glioma (HP:0009733)2.50632140
54Lymphoma (HP:0002665)2.50007105
55Colon cancer (HP:0003003)2.48808729
56Selective tooth agenesis (HP:0001592)2.48252185
57Subacute progressive viral hepatitis (HP:0006572)2.46422429
58Buphthalmos (HP:0000557)2.46213035
59Insidious onset (HP:0003587)2.44515935
60Termporal pattern (HP:0011008)2.44515935
61Papillary thyroid carcinoma (HP:0002895)2.42785022
62Oral leukoplakia (HP:0002745)2.42046493
63Rhabdomyosarcoma (HP:0002859)2.41115900
64Abnormality of the labia minora (HP:0012880)2.40564892
65Bladder carcinoma (HP:0002862)2.37316197
66Bladder neoplasm (HP:0009725)2.37316197
67Esophageal atresia (HP:0002032)2.36752651
68Biliary tract neoplasm (HP:0100574)2.34997133
69Missing ribs (HP:0000921)2.33952532
70Heterotopia (HP:0002282)2.31668312
71Absent frontal sinuses (HP:0002688)2.29127742
72Medulloblastoma (HP:0002885)2.28958940
73Neoplasm of the oral cavity (HP:0100649)2.28024667
74Abnormality of reticulocytes (HP:0004312)2.27875828
75Cerebellar dysplasia (HP:0007033)2.26500758
76Broad distal phalanx of finger (HP:0009836)2.25174756
77Rough bone trabeculation (HP:0100670)2.24557091
7811 pairs of ribs (HP:0000878)2.24001259
79Paralysis (HP:0003470)2.23058788
80Epistaxis (HP:0000421)2.22686169
81Thyroiditis (HP:0100646)2.22396110
82Hypoplasia of the pons (HP:0012110)2.22018473
83Abdominal situs inversus (HP:0003363)2.20883365
84Abnormality of abdominal situs (HP:0011620)2.20883365
85Prostate neoplasm (HP:0100787)2.19411632
86Recurrent sinusitis (HP:0011108)2.19037090
87Purpura (HP:0000979)2.17047145
88Cafe-au-lait spot (HP:0000957)2.16756107
89Deviation of the thumb (HP:0009603)2.16249414
90Bone marrow hypocellularity (HP:0005528)2.15636177
91Dyschromatopsia (HP:0007641)2.15472034
92Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.15134746
93Abnormality of the 4th metacarpal (HP:0010012)2.14033130
94Orthostatic hypotension (HP:0001278)2.13137796
95Transitional cell carcinoma of the bladder (HP:0006740)2.12492757
96Small intestinal stenosis (HP:0012848)2.12341560
97Duodenal stenosis (HP:0100867)2.12341560
98Autoimmune hemolytic anemia (HP:0001890)2.10797553
99Acute lymphatic leukemia (HP:0006721)2.10484558
100Large earlobe (HP:0009748)2.10031324
101Freckling (HP:0001480)2.09264999
102Reticulocytosis (HP:0001923)2.08444413
103Emphysema (HP:0002097)2.08088556
104Chronic diarrhea (HP:0002028)2.07473120
105Proximal placement of thumb (HP:0009623)2.07358560
106Gastrointestinal carcinoma (HP:0002672)2.05926369
107Malignant gastrointestinal tract tumors (HP:0006749)2.05926369
108Inflammation of the large intestine (HP:0002037)2.02801632
109Chronic sinusitis (HP:0011109)2.01049754
110Thyroid carcinoma (HP:0002890)2.00731737
111Increased nuchal translucency (HP:0010880)2.00311093
112Pancreatic islet-cell hyperplasia (HP:0004510)2.00128839
113Relative macrocephaly (HP:0004482)2.00047821
114Abnormality of pyrimidine metabolism (HP:0004353)1.99965795
115Ectopic kidney (HP:0000086)1.99388786
116Abnormality of the renal collecting system (HP:0004742)1.98887672
117Degeneration of the lateral corticospinal tracts (HP:0002314)1.98720842
118Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98720842
119Abnormality of the pons (HP:0007361)1.97227023
120Agnosia (HP:0010524)1.97168995
121Cellulitis (HP:0100658)1.96637698
122Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.96087456
123Chin dimple (HP:0010751)1.95522789
124Cerebral aneurysm (HP:0004944)1.94065217
125Ovarian neoplasm (HP:0100615)1.94001870
126Aqueductal stenosis (HP:0002410)1.93864714
127Sloping forehead (HP:0000340)1.90779671
128Short thumb (HP:0009778)1.90505594
129Tinnitus (HP:0000360)1.90037900
130High pitched voice (HP:0001620)1.89337955
131Ureteral duplication (HP:0000073)1.87769392
132Absent radius (HP:0003974)1.87740719
133Atresia of the external auditory canal (HP:0000413)1.87425995
134Hypergonadotropic hypogonadism (HP:0000815)1.86229875
135Abnormal trabecular bone morphology (HP:0100671)1.86139887
136Aplasia/Hypoplasia of the earlobes (HP:0009906)1.86133310
137Duplicated collecting system (HP:0000081)1.86112153
138Short humerus (HP:0005792)1.86018672
139Lymphopenia (HP:0001888)1.85821626
140Abnormal auditory evoked potentials (HP:0006958)1.85453573
141Abnormality of the calcaneus (HP:0008364)1.83925215
142Multiple enchondromatosis (HP:0005701)1.82718372
143Neoplasm of the heart (HP:0100544)1.82555896
144Abnormality of cells of the lymphoid lineage (HP:0012140)1.81460115
145Renal cell carcinoma (HP:0005584)1.81447190
146Gastrointestinal inflammation (HP:0004386)1.81304215
147Abnormality of the prostate (HP:0008775)1.80762098
148Birth length less than 3rd percentile (HP:0003561)1.79711869
149Abnormality of chromosome segregation (HP:0002916)1.79527756
150Flat occiput (HP:0005469)1.78483852
151Squamous cell carcinoma (HP:0002860)1.78293369
152Ileus (HP:0002595)1.78061937
153Basal ganglia calcification (HP:0002135)1.77787251
154Neoplasm of striated muscle (HP:0009728)1.77757907
155Renovascular hypertension (HP:0100817)1.77421113
156Leukopenia (HP:0001882)1.77418267
157Abnormality of the heme biosynthetic pathway (HP:0010472)1.77350824
158Prominent nose (HP:0000448)1.77329059
159Microretrognathia (HP:0000308)1.77224868
160Microtia (HP:0008551)1.77095029
161Abnormality of DNA repair (HP:0003254)1.76711253
162Nephroblastoma (Wilms tumor) (HP:0002667)1.76036265
163Basal cell carcinoma (HP:0002671)1.75698765
164Mediastinal lymphadenopathy (HP:0100721)1.73905075
165Bowel diverticulosis (HP:0005222)1.71798296
166Intestinal polyposis (HP:0200008)1.70944448
167Aplasia/Hypoplasia of the sternum (HP:0006714)1.70500478
168Breast carcinoma (HP:0003002)1.70368149
169Abnormality of the peritoneum (HP:0002585)1.70181784
170Conjunctival telangiectasia (HP:0000524)1.70110581
171Absent forearm bone (HP:0003953)1.69562781
172Aplasia involving forearm bones (HP:0009822)1.69562781
173Resting tremor (HP:0002322)1.67665173
174Abnormal lung lobation (HP:0002101)1.66852280
175Papilloma (HP:0012740)1.66699212
176Verrucae (HP:0200043)1.66699212
177Decreased motor nerve conduction velocity (HP:0003431)1.66354338
178Truncal obesity (HP:0001956)1.65728090
179Midline defect of the nose (HP:0004122)1.65168564
180Macrocytic anemia (HP:0001972)1.65049781
181Neoplasm of the pancreas (HP:0002894)1.64052191
182Abnormality of oral frenula (HP:0000190)1.63930166
183Neoplasm of the small intestine (HP:0100833)1.62367026
184Intestinal polyp (HP:0005266)1.62084250
185Aplasia/hypoplasia of the humerus (HP:0006507)1.61745794

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.91800036
2ZAK6.58497007
3VRK13.62838504
4RPS6KA53.07975154
5STK42.79642554
6CDC72.75948709
7MAP3K102.07347870
8SCYL22.06814046
9CDK92.04173107
10EEF2K1.95103668
11MST41.90214128
12PKN11.67532411
13NEK21.55467108
14PKN21.52981885
15BUB11.48378091
16SRPK11.48276035
17DAPK31.48013646
18MAP3K81.46583523
19AURKB1.46167982
20PIM11.42146529
21WEE11.41364287
22CHEK21.38608559
23RPS6KB21.31679855
24SMG11.31151679
25TTN1.26643178
26TTK1.06547410
27DYRK31.05940800
28TAF11.02785379
29FGFR21.00655245
30DYRK1B0.99710205
31PASK0.98652913
32EPHA20.94721337
33FRK0.91646659
34MET0.91307402
35MELK0.90396618
36ATR0.85439942
37AURKA0.82602436
38BTK0.78574342
39GRK60.77317597
40STK100.74086532
41PLK10.72822179
42PIM20.67943962
43EPHA30.66331873
44LATS10.66124359
45BRAF0.65953110
46PLK30.64418111
47ACVR1B0.63338465
48IKBKB0.62707451
49IRAK10.60931016
50ATM0.60683575
51TGFBR10.59982843
52MAPK110.59798701
53CHEK10.58754553
54AKT20.58557723
55FLT30.58361450
56RAF10.57445846
57CCNB10.55536550
58CDK40.55249097
59CSNK1D0.54729829
60FGR0.53365034
61MARK30.53167230
62FER0.52161063
63LRRK20.51659511
64PIK3CG0.51456999
65CDK120.51024741
66TEC0.49056774
67CDK20.47383896
68AKT30.46666113
69ROCK10.46014655
70MAP2K30.45823738
71MAP3K20.45398734
72NEK10.45350374
73IRAK20.45349139
74CAMK1D0.45323801
75CDK60.43975484
76SYK0.42524621
77PAK20.42381391
78STK30.40812022
79CDK10.40175645
80PRKAA10.39655814
81MAP3K50.39085843
82PTK60.38712044
83EIF2AK10.37902540
84EIF2AK30.37589492
85CDK70.36931956
86TRIB30.36929846
87KSR10.36528433
88BLK0.36191195
89BMPR20.36061967
90PRKCQ0.35342213
91PRKCI0.33767412
92STK390.33142980
93CHUK0.32744189
94CSNK1G30.31683257
95PNCK0.31162646
96SIK10.30609917
97PRKDC0.30601043
98PBK0.30151438
99STK240.30131299
100MTOR0.30022874
101IRAK30.29972293
102NUAK10.29793668
103BMX0.29611169
104NLK0.29165186
105PAK10.28543206
106MAP2K70.27295313
107CSNK1G10.26788777
108PDGFRA0.26095364
109ILK0.24666496
110CSNK1A1L0.24112209
111CLK10.23944249
112CAMK1G0.23912762
113JAK20.23366754
114ICK0.23256133
115MAP3K40.22963135
116GSK3A0.22745817
117PLK40.22060054
118BCR0.21114525
119NEK90.20873218
120KSR20.20585375
121BRD40.20299955
122TRPM70.20098792
123NME20.19808023
124BRSK20.19114164
125ALK0.17282077
126RIPK40.17200786
127MST1R0.16399859
128MAP2K10.15941657
129TESK20.15881825
130WNK10.15699876
131FGFR10.15691709
132MAPK140.15230493
133IRAK40.15009659
134CSF1R0.14895024
135RPS6KB10.14882770
136MAP3K140.14714483
137CAMK40.14551689
138CDK80.13663194
139AKT10.13414857
140ROCK20.13312877
141INSR0.13287389
142MAPKAPK50.13049789
143RPS6KA30.13023093
144LYN0.12937574
145CSNK2A20.12694865
146EIF2AK20.12432731

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050347.22318812
2* Viral carcinogenesis_Homo sapiens_hsa052033.51186513
3DNA replication_Homo sapiens_hsa030302.02286056
4* Systemic lupus erythematosus_Homo sapiens_hsa0532212.5203676
5Transcriptional misregulation in cancer_Homo sapiens_hsa052021.97778936
6Mismatch repair_Homo sapiens_hsa034301.80607572
7One carbon pool by folate_Homo sapiens_hsa006701.64436108
8Cell cycle_Homo sapiens_hsa041101.59758881
9Non-homologous end-joining_Homo sapiens_hsa034501.48971201
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21275033
11Nucleotide excision repair_Homo sapiens_hsa034201.20228049
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11788391
13Fanconi anemia pathway_Homo sapiens_hsa034601.10001636
14RNA transport_Homo sapiens_hsa030131.08907321
15Primary immunodeficiency_Homo sapiens_hsa053401.01021552
16Homologous recombination_Homo sapiens_hsa034400.90266646
17MicroRNAs in cancer_Homo sapiens_hsa052060.89234841
18Base excision repair_Homo sapiens_hsa034100.88473454
19Intestinal immune network for IgA production_Homo sapiens_hsa046720.87220876
20Spliceosome_Homo sapiens_hsa030400.84789147
21Vitamin B6 metabolism_Homo sapiens_hsa007500.79587489
22mRNA surveillance pathway_Homo sapiens_hsa030150.78727550
23Ribosome_Homo sapiens_hsa030100.77829124
24p53 signaling pathway_Homo sapiens_hsa041150.77422082
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74388848
26Sulfur relay system_Homo sapiens_hsa041220.74182778
27Selenocompound metabolism_Homo sapiens_hsa004500.74103339
28Small cell lung cancer_Homo sapiens_hsa052220.72903879
29Allograft rejection_Homo sapiens_hsa053300.70369436
30Autoimmune thyroid disease_Homo sapiens_hsa053200.62665094
31Graft-versus-host disease_Homo sapiens_hsa053320.61814513
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59593234
33Chronic myeloid leukemia_Homo sapiens_hsa052200.57579113
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53638926
35Bladder cancer_Homo sapiens_hsa052190.52283998
36Non-small cell lung cancer_Homo sapiens_hsa052230.50824769
37Fatty acid elongation_Homo sapiens_hsa000620.48333737
38HTLV-I infection_Homo sapiens_hsa051660.47861238
39Asthma_Homo sapiens_hsa053100.47401855
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46022673
41Nitrogen metabolism_Homo sapiens_hsa009100.45978151
42Oocyte meiosis_Homo sapiens_hsa041140.44959791
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44299477
44Tight junction_Homo sapiens_hsa045300.43475131
45Central carbon metabolism in cancer_Homo sapiens_hsa052300.40744036
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40681968
47Hippo signaling pathway_Homo sapiens_hsa043900.40382124
48Colorectal cancer_Homo sapiens_hsa052100.38511299
49mTOR signaling pathway_Homo sapiens_hsa041500.38398365
50Pyrimidine metabolism_Homo sapiens_hsa002400.37091713
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36563680
52Prostate cancer_Homo sapiens_hsa052150.36306105
53Glioma_Homo sapiens_hsa052140.35918025
54Proteoglycans in cancer_Homo sapiens_hsa052050.34991261
55Type I diabetes mellitus_Homo sapiens_hsa049400.34020167
56TGF-beta signaling pathway_Homo sapiens_hsa043500.33916380
57Basal cell carcinoma_Homo sapiens_hsa052170.33823714
58Lysine degradation_Homo sapiens_hsa003100.32839541
59Hematopoietic cell lineage_Homo sapiens_hsa046400.32393262
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32254654
61Pancreatic cancer_Homo sapiens_hsa052120.29984302
62Biosynthesis of amino acids_Homo sapiens_hsa012300.28875748
63Epstein-Barr virus infection_Homo sapiens_hsa051690.28736600
64RNA degradation_Homo sapiens_hsa030180.28673407
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28089180
66Melanoma_Homo sapiens_hsa052180.27483673
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27172723
68Focal adhesion_Homo sapiens_hsa045100.27017922
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26629954
70FoxO signaling pathway_Homo sapiens_hsa040680.26251173
71Apoptosis_Homo sapiens_hsa042100.26118650
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24688372
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24091261
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.23903081
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23871809
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22770884
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22400675
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21957602
79B cell receptor signaling pathway_Homo sapiens_hsa046620.21170042
80Endometrial cancer_Homo sapiens_hsa052130.20869497
81ECM-receptor interaction_Homo sapiens_hsa045120.20251209
82Renin-angiotensin system_Homo sapiens_hsa046140.19632929
83AMPK signaling pathway_Homo sapiens_hsa041520.19464188
84Adherens junction_Homo sapiens_hsa045200.19293669
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18930851
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18612707
87Pathways in cancer_Homo sapiens_hsa052000.18165704
88Galactose metabolism_Homo sapiens_hsa000520.18127479
89Measles_Homo sapiens_hsa051620.17654341
90RNA polymerase_Homo sapiens_hsa030200.17490995
91Hedgehog signaling pathway_Homo sapiens_hsa043400.17378948
92Proteasome_Homo sapiens_hsa030500.17208861
93Hepatitis B_Homo sapiens_hsa051610.17111619
94Influenza A_Homo sapiens_hsa051640.17025117
95N-Glycan biosynthesis_Homo sapiens_hsa005100.16854210
96Renal cell carcinoma_Homo sapiens_hsa052110.16838848
97Leishmaniasis_Homo sapiens_hsa051400.16170205
98Glutathione metabolism_Homo sapiens_hsa004800.15805052
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.14566038
100Sulfur metabolism_Homo sapiens_hsa009200.14177419
101Inositol phosphate metabolism_Homo sapiens_hsa005620.14103024
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.14039769
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.13956273
104Antigen processing and presentation_Homo sapiens_hsa046120.13120327
105Shigellosis_Homo sapiens_hsa051310.12659198
106Viral myocarditis_Homo sapiens_hsa054160.12270413
107Fatty acid biosynthesis_Homo sapiens_hsa000610.11977543
108Steroid biosynthesis_Homo sapiens_hsa001000.11759143
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.11523634
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11262632
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.11112794
112Purine metabolism_Homo sapiens_hsa002300.10939162
113Acute myeloid leukemia_Homo sapiens_hsa052210.10818734
114Pentose phosphate pathway_Homo sapiens_hsa000300.10464380
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.09660417
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.09593157
117Prolactin signaling pathway_Homo sapiens_hsa049170.08933748
118Basal transcription factors_Homo sapiens_hsa030220.07924534
119Herpes simplex infection_Homo sapiens_hsa051680.07716229
120Ether lipid metabolism_Homo sapiens_hsa005650.07510130
121Arginine and proline metabolism_Homo sapiens_hsa003300.07108770
122Thyroid cancer_Homo sapiens_hsa052160.06774631
123Platelet activation_Homo sapiens_hsa046110.06703939
124Wnt signaling pathway_Homo sapiens_hsa043100.05847367
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.05559378
126Notch signaling pathway_Homo sapiens_hsa043300.05413048
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.05261119
128Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.04863994
129HIF-1 signaling pathway_Homo sapiens_hsa040660.04174701
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.03917215
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.03604961
132Estrogen signaling pathway_Homo sapiens_hsa049150.03583137
133Insulin resistance_Homo sapiens_hsa049310.02563481
134ErbB signaling pathway_Homo sapiens_hsa040120.02120883
135Carbon metabolism_Homo sapiens_hsa012000.01917776
136Dorso-ventral axis formation_Homo sapiens_hsa043200.01532708

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