HIST1H4I

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1innate immune response in mucosa (GO:0002227)9.73605544
2mucosal immune response (GO:0002385)7.95586199
3organ or tissue specific immune response (GO:0002251)7.22117896
4DNA replication-dependent nucleosome organization (GO:0034723)7.12013096
5DNA replication-dependent nucleosome assembly (GO:0006335)7.12013096
6antimicrobial humoral response (GO:0019730)6.90627495
7telomere maintenance via semi-conservative replication (GO:0032201)5.63812635
8DNA strand elongation involved in DNA replication (GO:0006271)5.63281924
9DNA replication initiation (GO:0006270)5.46485737
10CENP-A containing nucleosome assembly (GO:0034080)5.43878146
11DNA strand elongation (GO:0022616)5.38580525
12chromatin remodeling at centromere (GO:0031055)5.37866615
13DNA unwinding involved in DNA replication (GO:0006268)5.31190154
14telomere maintenance via recombination (GO:0000722)4.99646236
15mitotic recombination (GO:0006312)4.86299651
16protein localization to kinetochore (GO:0034501)4.71803627
17DNA replication-independent nucleosome organization (GO:0034724)4.62946923
18DNA replication-independent nucleosome assembly (GO:0006336)4.62946923
19nucleosome assembly (GO:0006334)4.59245799
20chromatin assembly or disassembly (GO:0006333)4.46430273
21negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.46308744
22nucleotide-excision repair, DNA gap filling (GO:0006297)4.44646766
23DNA replication checkpoint (GO:0000076)4.36517112
24histone exchange (GO:0043486)4.33239611
25telomere maintenance via telomere lengthening (GO:0010833)4.29855359
26regulation of histone H3-K9 methylation (GO:0051570)4.26196821
27protein localization to chromosome, centromeric region (GO:0071459)4.13288254
28protein-DNA complex assembly (GO:0065004)4.12464356
29ribosomal small subunit assembly (GO:0000028)4.12148061
30chromatin assembly (GO:0031497)4.09709726
31kinetochore organization (GO:0051383)4.03359811
32DNA deamination (GO:0045006)3.98993106
33protein K6-linked ubiquitination (GO:0085020)3.97999836
34deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.95372634
35nucleosome organization (GO:0034728)3.91902444
36viral transcription (GO:0019083)3.83123931
37pore complex assembly (GO:0046931)3.79925483
38regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.75895891
39translational termination (GO:0006415)3.74572329
40folic acid-containing compound biosynthetic process (GO:0009396)3.72979409
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.72116113
42somatic hypermutation of immunoglobulin genes (GO:0016446)3.72116113
43mitotic chromosome condensation (GO:0007076)3.68408552
44IMP biosynthetic process (GO:0006188)3.68033786
45regulation of megakaryocyte differentiation (GO:0045652)3.63100819
46telomere maintenance (GO:0000723)3.62905082
47protein-DNA complex subunit organization (GO:0071824)3.62531624
48telomere organization (GO:0032200)3.61553811
49B cell mediated immunity (GO:0019724)3.61120973
50attachment of spindle microtubules to kinetochore (GO:0008608)3.59515977
51translesion synthesis (GO:0019985)3.58521118
52immunoglobulin mediated immune response (GO:0016064)3.57977361
53mitotic sister chromatid segregation (GO:0000070)3.55924500
54sister chromatid segregation (GO:0000819)3.51698172
55DNA topological change (GO:0006265)3.47326825
56mitotic metaphase plate congression (GO:0007080)3.46712187
57kinetochore assembly (GO:0051382)3.44775109
58defense response to Gram-positive bacterium (GO:0050830)3.44694176
59IMP metabolic process (GO:0046040)3.42145577
60regulation of spindle organization (GO:0090224)3.38517291
61maturation of SSU-rRNA (GO:0030490)3.38438415
62mitotic nuclear envelope disassembly (GO:0007077)3.37972352
63translational elongation (GO:0006414)3.34800174
64regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.34622826
65regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.33926563
66SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.30889494
67cotranslational protein targeting to membrane (GO:0006613)3.25371915
68nucleobase biosynthetic process (GO:0046112)3.24684314
69DNA duplex unwinding (GO:0032508)3.24276735
70ribosomal large subunit biogenesis (GO:0042273)3.24248555
71protein targeting to ER (GO:0045047)3.23203852
72nuclear pore organization (GO:0006999)3.23165565
73DNA geometric change (GO:0032392)3.22974022
74metaphase plate congression (GO:0051310)3.21745547
75spindle checkpoint (GO:0031577)3.21434776
76ATP-dependent chromatin remodeling (GO:0043044)3.20169672
77ribosomal small subunit biogenesis (GO:0042274)3.19965370
78viral mRNA export from host cell nucleus (GO:0046784)3.18208318
79meiotic chromosome segregation (GO:0045132)3.17608315
80nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.13205913
81mismatch repair (GO:0006298)3.12994973
82spindle assembly checkpoint (GO:0071173)3.12949557
83nuclear pore complex assembly (GO:0051292)3.12073914
84translational initiation (GO:0006413)3.11603858
85nuclear envelope disassembly (GO:0051081)3.11411396
86membrane disassembly (GO:0030397)3.11411396
87negative regulation of chromosome segregation (GO:0051985)3.10249951
88establishment of protein localization to endoplasmic reticulum (GO:0072599)3.09878674
89negative regulation of mitotic sister chromatid segregation (GO:0033048)3.09718173
90negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09718173
91negative regulation of sister chromatid segregation (GO:0033046)3.09718173
92negative regulation of mitotic sister chromatid separation (GO:2000816)3.09718173
93negative regulation of B cell apoptotic process (GO:0002903)3.06922572
94regulation of nuclear cell cycle DNA replication (GO:0033262)3.06371956
95DNA synthesis involved in DNA repair (GO:0000731)3.05474205
96establishment of chromosome localization (GO:0051303)3.05248069
97postreplication repair (GO:0006301)3.03846480
98regulation of chromosome segregation (GO:0051983)3.00988626
99spliceosomal snRNP assembly (GO:0000387)3.00749106
100proline biosynthetic process (GO:0006561)3.00586647
101protein localization to endoplasmic reticulum (GO:0070972)3.00170057
102cellular protein complex disassembly (GO:0043624)3.00122413
103establishment of integrated proviral latency (GO:0075713)2.99568967
104negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.99474705
105regulation of mitotic metaphase/anaphase transition (GO:0030071)2.98488097
106antibacterial humoral response (GO:0019731)2.97335266
107mitotic spindle assembly checkpoint (GO:0007094)2.96567651
108transcription-coupled nucleotide-excision repair (GO:0006283)2.96535961
109mitotic cell cycle (GO:0000278)2.94995180
110positive regulation of histone methylation (GO:0031062)2.94544346
111positive regulation of chromosome segregation (GO:0051984)2.94107177
112regulation of gene silencing (GO:0060968)2.92699279
113rRNA processing (GO:0006364)2.92379974
114deoxyribonucleotide biosynthetic process (GO:0009263)2.91688752
115protein localization to chromosome (GO:0034502)2.91266058
116regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.90827919
117non-recombinational repair (GO:0000726)2.80514752
118double-strand break repair via nonhomologous end joining (GO:0006303)2.80514752
119B cell receptor signaling pathway (GO:0050853)2.78239514
120microtubule depolymerization (GO:0007019)2.76635353
121pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.73435548
122pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.72226865
123regulation of translational fidelity (GO:0006450)2.68808321
124positive regulation of alpha-beta T cell proliferation (GO:0046641)2.66295064
125peptidyl-arginine omega-N-methylation (GO:0035247)2.62201612
126DNA catabolic process, exonucleolytic (GO:0000738)2.62126144
127chromosome segregation (GO:0007059)2.57624332
128regulation of B cell apoptotic process (GO:0002902)2.55622300
129regulation of centrosome cycle (GO:0046605)2.55237385
130cytidine metabolic process (GO:0046087)2.54156515
131cytidine catabolic process (GO:0006216)2.54156515
132cytidine deamination (GO:0009972)2.54156515
133purine nucleobase biosynthetic process (GO:0009113)2.53624734
134positive regulation of B cell differentiation (GO:0045579)2.52277935
135somatic cell DNA recombination (GO:0016444)2.50997748
136somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.50997748
137somatic recombination of immunoglobulin gene segments (GO:0016447)2.50962355
138DNA ligation (GO:0006266)2.49984512
139somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.43966861
140somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.43966861
141isotype switching (GO:0045190)2.43966861
142establishment of viral latency (GO:0019043)2.43327177
143histone arginine methylation (GO:0034969)2.43304612

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.06095237
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.91207447
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.40122269
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.32250842
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.31013742
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.12436464
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.09936865
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.81744258
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49181894
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42591571
11* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.38749958
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35706493
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.31559768
14* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30264038
15* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29060760
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.27690383
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.26553670
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.25175940
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.22618206
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.14575879
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13314363
22VDR_23849224_ChIP-Seq_CD4+_Human2.09844451
23* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.07957833
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.05046965
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03947631
26* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85285301
27ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.84933242
28XRN2_22483619_ChIP-Seq_HELA_Human1.84768190
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80879070
30ERG_20887958_ChIP-Seq_HPC-7_Mouse1.74751455
31* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74229067
32FOXP3_21729870_ChIP-Seq_TREG_Human1.73927016
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72396923
34AR_21909140_ChIP-Seq_LNCAP_Human1.72382138
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.71449848
36CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.71306619
37* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71067109
38GATA1_22025678_ChIP-Seq_K562_Human1.71047791
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67389788
40* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66197951
41IRF1_19129219_ChIP-ChIP_H3396_Human1.65360800
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64045872
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62420895
44* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58720444
45* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58562543
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57223155
47DCP1A_22483619_ChIP-Seq_HELA_Human1.56429248
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53001362
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.50576584
50* ELK1_19687146_ChIP-ChIP_HELA_Human1.49858422
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46273322
52* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45866019
53TTF2_22483619_ChIP-Seq_HELA_Human1.42716380
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41097483
55* SOX2_16153702_ChIP-ChIP_HESCs_Human1.40201795
56* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34730912
57CIITA_25753668_ChIP-Seq_RAJI_Human1.34445000
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34113699
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33348257
60GABP_19822575_ChIP-Seq_HepG2_Human1.32645629
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31907396
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31262300
63* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28901287
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28722657
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24900546
66* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24870775
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23424685
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22530260
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.21741425
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20962825
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19686610
72* ETS1_22383799_ChIP-Seq_G1ME_Mouse1.17212554
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13904937
74SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13432144
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11206209
76IRF8_22096565_ChIP-ChIP_GC-B_Human1.10604015
77MAF_26560356_Chip-Seq_TH1_Human1.09652826
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.09598030
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09349472
80* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09249434
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02700974
82MYC_18940864_ChIP-ChIP_HL60_Human1.02042536
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01665694
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01578361
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00460099
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99470664
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99158999
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99142374
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98333236
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97743032
91BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96923039
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95997662
93VDR_21846776_ChIP-Seq_THP-1_Human0.95117614
94NANOG_16153702_ChIP-ChIP_HESCs_Human0.93872654
95POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93128629
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92886188
97MYC_22102868_ChIP-Seq_BL_Human0.92814427
98KDM5A_27292631_Chip-Seq_BREAST_Human0.92752632
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88660523
100EGR1_19374776_ChIP-ChIP_THP-1_Human0.87697599
101MYB_26560356_Chip-Seq_TH1_Human0.87623044
102ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87553511
103TFEB_21752829_ChIP-Seq_HELA_Human0.86890219
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83946365
105ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83706000
106KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83484093
107MYB_26560356_Chip-Seq_TH2_Human0.81460275
108* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.81394075
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81029192
110CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.78972106
111* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.78339549
112NOTCH1_21737748_ChIP-Seq_TLL_Human0.77400367
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.77178749
114GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76877034
115NCOR1_26117541_ChIP-Seq_K562_Human0.75823298
116SALL4_22934838_ChIP-ChIP_CD34+_Human0.74570370
117ZNF263_19887448_ChIP-Seq_K562_Human0.74187969
118UTX_26944678_Chip-Seq_JUKART_Human0.73145372
119CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.72551586
120ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.71419742

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.43259383
2MP0003111_abnormal_nucleus_morphology4.88599391
3MP0003693_abnormal_embryo_hatching4.83640880
4MP0008057_abnormal_DNA_replication4.25686078
5MP0003077_abnormal_cell_cycle4.16991498
6MP0004957_abnormal_blastocyst_morpholog3.83486911
7MP0005645_abnormal_hypothalamus_physiol3.76874061
8MP0008058_abnormal_DNA_repair3.67692016
9MP0009697_abnormal_copulation3.30437158
10MP0004147_increased_porphyrin_level2.97775321
11MP0008932_abnormal_embryonic_tissue2.89504133
12MP0008007_abnormal_cellular_replicative2.72417945
13MP0002396_abnormal_hematopoietic_system2.50169506
14MP0005464_abnormal_platelet_physiology2.49237333
15MP0003656_abnormal_erythrocyte_physiolo2.48458583
16MP0010307_abnormal_tumor_latency2.46485286
17MP0000490_abnormal_crypts_of2.12966520
18MP0000350_abnormal_cell_proliferation2.11900243
19MP0005083_abnormal_biliary_tract2.05432754
20MP0008877_abnormal_DNA_methylation2.02993318
21MP0001730_embryonic_growth_arrest2.01378724
22MP0002166_altered_tumor_susceptibility2.01097359
23MP0000372_irregular_coat_pigmentation1.94747126
24MP0002138_abnormal_hepatobiliary_system1.94287955
25MP0003786_premature_aging1.93036022
26MP0003806_abnormal_nucleotide_metabolis1.88857585
27MP0006054_spinal_hemorrhage1.75389455
28MP0001661_extended_life_span1.71021262
29MP0004808_abnormal_hematopoietic_stem1.65060415
30MP0005387_immune_system_phenotype1.63436879
31MP0001790_abnormal_immune_system1.63436879
32MP0005000_abnormal_immune_tolerance1.63345328
33MP0002019_abnormal_tumor_incidence1.63047211
34MP0002006_tumorigenesis1.60025124
35MP0000313_abnormal_cell_death1.59748451
36MP0006035_abnormal_mitochondrial_morpho1.54573740
37MP0003123_paternal_imprinting1.54100475
38MP0002080_prenatal_lethality1.52615478
39MP0001697_abnormal_embryo_size1.51411978
40MP0002085_abnormal_embryonic_tissue1.43977155
41MP0003183_abnormal_peptide_metabolism1.41251954
42MP0002452_abnormal_antigen_presenting1.41115908
43MP0002723_abnormal_immune_serum1.40214449
44MP0002398_abnormal_bone_marrow1.33228141
45MP0005171_absent_coat_pigmentation1.32541242
46MP0001672_abnormal_embryogenesis/_devel1.32174655
47MP0005380_embryogenesis_phenotype1.32174655
48MP0002084_abnormal_developmental_patter1.27960527
49MP0000703_abnormal_thymus_morphology1.26784093
50MP0003136_yellow_coat_color1.26114314
51MP0003121_genomic_imprinting1.24223060
52MP0001293_anophthalmia1.22718552
53MP0002722_abnormal_immune_system1.22405984
54MP0002210_abnormal_sex_determination1.21812273
55MP0004197_abnormal_fetal_growth/weight/1.15328259
56MP0001145_abnormal_male_reproductive1.15003896
57MP0010352_gastrointestinal_tract_polyps1.14941336
58MP0009333_abnormal_splenocyte_physiolog1.14676602
59MP0002086_abnormal_extraembryonic_tissu1.14245252
60MP0005397_hematopoietic_system_phenotyp1.13172554
61MP0001545_abnormal_hematopoietic_system1.13172554
62MP0008995_early_reproductive_senescence1.13100074
63MP0000689_abnormal_spleen_morphology1.12479091
64MP0001727_abnormal_embryo_implantation1.08926539
65MP0003984_embryonic_growth_retardation1.08862659
66MP0001929_abnormal_gametogenesis1.07784543
67MP0003941_abnormal_skin_development1.04848153
68MP0002088_abnormal_embryonic_growth/wei1.03684710
69MP0003763_abnormal_thymus_physiology1.03021489
70MP0002160_abnormal_reproductive_system1.02276048
71MP0003718_maternal_effect1.00812718
72MP0002163_abnormal_gland_morphology1.00718783
73MP0002429_abnormal_blood_cell1.00465128
74MP0006292_abnormal_olfactory_placode1.00174056
75MP0004133_heterotaxia0.99431864
76MP0000653_abnormal_sex_gland0.94746231
77MP0000685_abnormal_immune_system0.94318053
78MP0005310_abnormal_salivary_gland0.94196353
79MP0003567_abnormal_fetal_cardiomyocyte0.94107826
80MP0003937_abnormal_limbs/digits/tail_de0.91737193
81MP0002095_abnormal_skin_pigmentation0.91602765
82MP0002139_abnormal_hepatobiliary_system0.90013263
83MP0006036_abnormal_mitochondrial_physio0.89429375
84MP0005025_abnormal_response_to0.89079844
85MP0005075_abnormal_melanosome_morpholog0.88243738
86MP0000358_abnormal_cell_content/0.87282867
87MP0005451_abnormal_body_composition0.87169219
88MP0002132_abnormal_respiratory_system0.85865791
89MP0002111_abnormal_tail_morphology0.85823759
90MP0002877_abnormal_melanocyte_morpholog0.85150259
91MP0003890_abnormal_embryonic-extraembry0.81827353
92MP0009785_altered_susceptibility_to0.81584744
93MP0000716_abnormal_immune_system0.81478943
94MP0005647_abnormal_sex_gland0.81383514
95MP0005084_abnormal_gallbladder_morpholo0.81235118
96MP0010155_abnormal_intestine_physiology0.80222142
97MP0004264_abnormal_extraembryonic_tissu0.79090118
98MP0005076_abnormal_cell_differentiation0.78888127
99MP0003186_abnormal_redox_activity0.77866081
100MP0005671_abnormal_response_to0.75770258
101MP0005384_cellular_phenotype0.75631513
102MP0001764_abnormal_homeostasis0.75316940
103MP0001845_abnormal_inflammatory_respons0.74390101
104MP0004947_skin_inflammation0.74332752
105MP0002148_abnormal_hypersensitivity_rea0.74253003
106MP0005174_abnormal_tail_pigmentation0.73520288
107MP0000383_abnormal_hair_follicle0.73035116
108MP0002092_abnormal_eye_morphology0.71424362
109MP0000858_altered_metastatic_potential0.71232139
110MP0009763_increased_sensitivity_to0.70525321
111MP0001915_intracranial_hemorrhage0.69909476
112MP0003699_abnormal_female_reproductive0.69550656
113MP0002697_abnormal_eye_size0.68923068
114MP0008872_abnormal_physiological_respon0.68791407
115MP0001286_abnormal_eye_development0.68185797
116MP0005389_reproductive_system_phenotype0.67417572
117MP0002075_abnormal_coat/hair_pigmentati0.66565332
118MP0000015_abnormal_ear_pigmentation0.66100974
119MP0000477_abnormal_intestine_morphology0.66026213
120MP0005220_abnormal_exocrine_pancreas0.65448520
121MP0005621_abnormal_cell_physiology0.65009293
122MP0000598_abnormal_liver_morphology0.64486037
123MP0009379_abnormal_foot_pigmentation0.64113327
124MP0008770_decreased_survivor_rate0.64056691
125MP0001873_stomach_inflammation0.63925524
126MP0000609_abnormal_liver_physiology0.63083841
127MP0002420_abnormal_adaptive_immunity0.62679319
128MP0000465_gastrointestinal_hemorrhage0.62273861
129MP0010030_abnormal_orbit_morphology0.61100680
130MP0001119_abnormal_female_reproductive0.60371054
131MP0001819_abnormal_immune_cell0.60286524
132MP0005410_abnormal_fertilization0.58180329
133MP0001800_abnormal_humoral_immune0.58006119
134MP0002009_preneoplasia0.57513726
135MP0005266_abnormal_metabolism0.57305537
136MP0001835_abnormal_antigen_presentation0.57304687
137MP0008789_abnormal_olfactory_epithelium0.57055945
138MP0003698_abnormal_male_reproductive0.56851114
139MP0001186_pigmentation_phenotype0.55922068
140MP0009703_decreased_birth_body0.55529620

Predicted human phenotypes

RankGene SetZ-score
1IgA deficiency (HP:0002720)5.62438935
2Abnormality of cells of the erythroid lineage (HP:0012130)5.34741798
3Abnormal number of erythroid precursors (HP:0012131)5.33778855
4Reticulocytopenia (HP:0001896)5.32830149
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.90978654
6Gastrointestinal stroma tumor (HP:0100723)4.88321559
7Chromsome breakage (HP:0040012)4.78550237
8Abnormality of the heme biosynthetic pathway (HP:0010472)4.49867370
9Birth length less than 3rd percentile (HP:0003561)4.41361174
10Abnormality of chromosome stability (HP:0003220)3.87780888
11Cholecystitis (HP:0001082)3.85637914
12Abnormal gallbladder physiology (HP:0012438)3.85637914
13Recurrent sinusitis (HP:0011108)3.74197754
14Petechiae (HP:0000967)3.69796897
15Recurrent bronchitis (HP:0002837)3.66662318
16Duplicated collecting system (HP:0000081)3.66439822
17Macrocytic anemia (HP:0001972)3.62281890
18Agammaglobulinemia (HP:0004432)3.57132496
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.44370573
20Selective tooth agenesis (HP:0001592)3.43523766
21Lymphopenia (HP:0001888)3.43137632
22Meckel diverticulum (HP:0002245)3.39935556
23Abnormality of the preputium (HP:0100587)3.37002667
24Pallor (HP:0000980)3.34848354
25IgG deficiency (HP:0004315)3.27884215
26Poikilocytosis (HP:0004447)3.23971810
27Abnormality of cells of the lymphoid lineage (HP:0012140)3.21911356
28Abnormality of the ileum (HP:0001549)3.21571189
29Abnormality of the renal collecting system (HP:0004742)3.18851347
30Abnormality of reticulocytes (HP:0004312)3.16507077
3111 pairs of ribs (HP:0000878)3.13868274
32Aplastic anemia (HP:0001915)3.12600118
33Duodenal stenosis (HP:0100867)3.09381945
34Small intestinal stenosis (HP:0012848)3.09381945
35Abnormal number of incisors (HP:0011064)3.05426006
36Orthostatic hypotension (HP:0001278)3.03060892
37Dry hair (HP:0011359)3.00430147
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.99705241
39Myelodysplasia (HP:0002863)2.90584918
40Impulsivity (HP:0100710)2.84149091
41Chronic diarrhea (HP:0002028)2.82455625
42Oral leukoplakia (HP:0002745)2.80964798
43Sloping forehead (HP:0000340)2.80302460
44Spontaneous hematomas (HP:0007420)2.75156604
45Breast hypoplasia (HP:0003187)2.72866820
46Bone marrow hypocellularity (HP:0005528)2.66201335
47Abnormal platelet volume (HP:0011876)2.65400736
48Cellulitis (HP:0100658)2.64397340
49Patellar aplasia (HP:0006443)2.63553606
50Meningitis (HP:0001287)2.63513471
51Absent thumb (HP:0009777)2.63401784
52Abnormality of the duodenum (HP:0002246)2.63321287
53Microretrognathia (HP:0000308)2.59553684
54Ectopic kidney (HP:0000086)2.58879641
55Colon cancer (HP:0003003)2.54200558
56Supernumerary spleens (HP:0009799)2.52951255
57Absent radius (HP:0003974)2.51988459
58Prolonged bleeding time (HP:0003010)2.51986107
59Colitis (HP:0002583)2.51731276
60Increased mean platelet volume (HP:0011877)2.50940932
61Medulloblastoma (HP:0002885)2.48237637
62Increased hepatocellular lipid droplets (HP:0006565)2.47543322
63Megaloblastic anemia (HP:0001889)2.45445333
64Abnormality of the prostate (HP:0008775)2.45352027
65Acanthocytosis (HP:0001927)2.44232618
66Abnormality of the pons (HP:0007361)2.42205813
67Triphalangeal thumb (HP:0001199)2.39736903
68Abnormal lung lobation (HP:0002101)2.39604866
69Aplasia/Hypoplasia of the patella (HP:0006498)2.38325206
70Asplenia (HP:0001746)2.37126230
71Neoplasm of the pancreas (HP:0002894)2.36215396
72Abnormality of T cell physiology (HP:0011840)2.35520940
73B lymphocytopenia (HP:0010976)2.34183027
74Purpura (HP:0000979)2.33010862
75Clubbing of toes (HP:0100760)2.32590761
76Aplasia involving forearm bones (HP:0009822)2.32331371
77Absent forearm bone (HP:0003953)2.32331371
78Hypoplasia of the capital femoral epiphysis (HP:0003090)2.30658893
79Agnosia (HP:0010524)2.30442968
80Osteomyelitis (HP:0002754)2.30006544
81Recurrent pneumonia (HP:0006532)2.27602075
82Abnormality of the carotid arteries (HP:0005344)2.27107111
83Prominent nose (HP:0000448)2.27022294
84Emphysema (HP:0002097)2.26354683
85Type I transferrin isoform profile (HP:0003642)2.26344880
86Abnormality of DNA repair (HP:0003254)2.25813919
87Ependymoma (HP:0002888)2.25383994
88Recurrent lower respiratory tract infections (HP:0002783)2.25003282
89Recurrent viral infections (HP:0004429)2.23963968
90Hypoplasia of the pons (HP:0012110)2.23526386
91Horseshoe kidney (HP:0000085)2.22998439
92Onycholysis (HP:0001806)2.22300902
93Panhypogammaglobulinemia (HP:0003139)2.21206306
94Cerebral hypomyelination (HP:0006808)2.20014379
95Pancytopenia (HP:0001876)2.16300450
96IgM deficiency (HP:0002850)2.15618860
97Lymphoma (HP:0002665)2.15023285
98Lipid accumulation in hepatocytes (HP:0006561)2.14905245
99Microvesicular hepatic steatosis (HP:0001414)2.14267541
100Erythema (HP:0010783)2.13137215
101Cafe-au-lait spot (HP:0000957)2.12886663
102Abnormality of pyrimidine metabolism (HP:0004353)2.09829159
103Decreased activity of mitochondrial respiratory chain (HP:0008972)2.09795610
104Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.09795610
105Autoimmune hemolytic anemia (HP:0001890)2.08402240
106Basal cell carcinoma (HP:0002671)2.07590147
107Rhabdomyosarcoma (HP:0002859)2.07075574
108Premature graying of hair (HP:0002216)2.06979996
109Short thumb (HP:0009778)2.06927340
110Vasculitis (HP:0002633)2.06815782
111Aplasia/Hypoplasia of the spleen (HP:0010451)2.06589975
112Exertional dyspnea (HP:0002875)2.03957475
113Urticaria (HP:0001025)2.03278436
114Bronchitis (HP:0012387)2.02231444
115Increased IgM level (HP:0003496)2.01588635
116Impaired platelet aggregation (HP:0003540)2.00929311
117Abnormal platelet function (HP:0011869)2.00929311
118Carpal bone hypoplasia (HP:0001498)2.00234056
119Nephroblastoma (Wilms tumor) (HP:0002667)2.00134559
120Progressive muscle weakness (HP:0003323)1.99663038
121Squamous cell carcinoma (HP:0002860)1.97601915
122Menorrhagia (HP:0000132)1.95863820
123Hypertensive crisis (HP:0100735)1.95087240
124Abnormality of B cell number (HP:0010975)1.94988999
125Reticulocytosis (HP:0001923)1.94825349
126Prostate neoplasm (HP:0100787)1.94317882
127Tracheoesophageal fistula (HP:0002575)1.93471054
128Skin rash (HP:0000988)1.93011325
129Cerebellar dysplasia (HP:0007033)1.92703870
130Dyschromatopsia (HP:0007641)1.92011008
131High pitched voice (HP:0001620)1.90404795
132Rough bone trabeculation (HP:0100670)1.90203002
133Missing ribs (HP:0000921)1.89899161
134Epistaxis (HP:0000421)1.89390457
1353-Methylglutaconic aciduria (HP:0003535)1.89363415
136Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87762348
137Abnormality of T cells (HP:0002843)1.84257664
138Ridged nail (HP:0001807)1.84192446
139Cerebral edema (HP:0002181)1.84127724
140Degeneration of anterior horn cells (HP:0002398)1.83699877
141Abnormality of the anterior horn cell (HP:0006802)1.83699877
142Abnormal umbilical cord blood vessels (HP:0011403)1.82975867
143Single umbilical artery (HP:0001195)1.82975867
144Abnormality of the fetal cardiovascular system (HP:0010948)1.82975867
145Combined immunodeficiency (HP:0005387)1.82526533
146Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82445181
147Abnormality of alanine metabolism (HP:0010916)1.82445181
148Hyperalaninemia (HP:0003348)1.82445181
149Leukopenia (HP:0001882)1.82130767
150Thrombocytosis (HP:0001894)1.80402365
151Abnormality of cochlea (HP:0000375)1.80220664
152Cellular immunodeficiency (HP:0005374)1.79761497
153Embryonal renal neoplasm (HP:0011794)1.79487197
154Ovarian neoplasm (HP:0100615)1.79045695
155Chronic otitis media (HP:0000389)1.78157240
156Abnormality of glycolysis (HP:0004366)1.77756780
157Facial cleft (HP:0002006)1.75977264
158Anencephaly (HP:0002323)1.75881125
159Abnormality of male internal genitalia (HP:0000022)1.74700055
160Increased serum lactate (HP:0002151)1.73960370
161Hypergonadotropic hypogonadism (HP:0000815)1.72910123
162Cortical dysplasia (HP:0002539)1.70303265
163Paralysis (HP:0003470)1.69794834
164Neutropenia (HP:0001875)1.69718507
165Inflammation of the large intestine (HP:0002037)1.69547202

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK17.92435657
2ZAK5.04654797
3VRK13.94499896
4CDC73.62311442
5WEE13.47100635
6BUB13.45785780
7SRPK12.33491929
8STK42.24101808
9NEK22.20102665
10RPS6KA52.12361097
11TTK1.90428178
12DYRK31.89468320
13ACVR1B1.86906085
14EIF2AK11.81505267
15NME21.76748558
16AURKB1.74278622
17STK161.65737505
18SCYL21.64635552
19PLK11.64181758
20CHEK21.63997478
21MAP3K101.55134408
22EIF2AK31.52984000
23SMG11.49918917
24MAP3K81.41772867
25BRSK21.40580826
26PIM11.40469063
27ATR1.40403448
28EPHA21.37687154
29NEK11.35374073
30RIPK41.30410370
31PASK1.26616794
32CDK71.26400932
33AURKA1.26054807
34RPS6KB21.24508273
35TAF11.24394978
36CDK121.16714825
37PLK41.15026929
38VRK21.12814627
39MKNK11.12647836
40TESK21.12339127
41PBK1.08143314
42BRD41.05543137
43CCNB11.00761625
44CDK40.91142382
45MKNK20.90529657
46PLK30.88067641
47FLT30.84691816
48CDK90.84279752
49CHEK10.84207845
50BRSK10.81355283
51CLK10.79498316
52EEF2K0.79387692
53SYK0.78684124
54BMPR20.71266737
55EPHA30.70188402
56IRAK40.70180644
57BLK0.69537418
58EIF2AK20.67209808
59ATM0.66784965
60STK100.66119243
61RAF10.62116060
62CDK20.60702246
63CSNK1G30.57578001
64BRAF0.56233327
65ARAF0.56033300
66DAPK30.54686349
67MELK0.53569873
68DYRK1B0.52903872
69CDK10.52637236
70PAK10.51433673
71PRKCQ0.50766751
72IKBKB0.46971531
73PRKCI0.46946901
74BMX0.46773232
75JAK20.46538361
76MAP4K10.45093996
77TEC0.44840037
78CSNK1G10.44223252
79NME10.43305938
80PKN10.43001251
81CSNK2A20.42326832
82TSSK60.41771448
83AKT20.41305720
84MAPK110.40987022
85CSNK2A10.39300094
86KSR20.38659466
87BTK0.38116853
88YES10.37489337
89RPS6KA40.36890112
90NEK90.35992376
91MST40.34904260
92PRKAA10.33572727
93PAK40.33540929
94STK30.32829989
95PDK20.31657769
96GRK60.30475433
97PIM20.30022835
98PIK3CG0.29913114
99KDR0.29210414
100CDK190.27846369
101CSNK1D0.27061488
102CDK80.26842553
103UHMK10.26609563
104PRKDC0.26190111
105DYRK20.25822365
106LYN0.24676754
107NUAK10.24541610
108JAK30.24280877
109CSNK1A1L0.24010390
110LRRK20.23616103
111PRKCD0.20609149
112BCKDK0.18724200
113MARK30.18719431
114MAP3K40.18233384
115CDK60.18057339
116CSF1R0.17603514
117MATK0.17339181
118AKT10.16453382
119STK240.15667010
120ILK0.15207016
121IKBKE0.14851976
122ALK0.13932485
123MAPKAPK50.13584754
124MAPKAPK30.13524111
125MAP2K70.12754125
126MAP3K110.12670769
127ICK0.12286086
128DAPK10.12106357
129TGFBR10.11747746
130HIPK20.11375246
131MAPK140.10248432

Predicted pathways (KEGG)

RankGene SetZ-score
1* Systemic lupus erythematosus_Homo sapiens_hsa053226.92055914
2DNA replication_Homo sapiens_hsa030305.18461169
3Mismatch repair_Homo sapiens_hsa034304.26447678
4* Alcoholism_Homo sapiens_hsa050343.84136413
5Ribosome_Homo sapiens_hsa030103.17117352
6Homologous recombination_Homo sapiens_hsa034403.12377939
7Base excision repair_Homo sapiens_hsa034102.81984391
8Nucleotide excision repair_Homo sapiens_hsa034202.75139113
9Spliceosome_Homo sapiens_hsa030402.72201225
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59185892
11Cell cycle_Homo sapiens_hsa041102.52726769
12One carbon pool by folate_Homo sapiens_hsa006702.50092482
13Fanconi anemia pathway_Homo sapiens_hsa034602.46981423
14RNA polymerase_Homo sapiens_hsa030202.46367696
15Pyrimidine metabolism_Homo sapiens_hsa002402.18622302
16RNA transport_Homo sapiens_hsa030132.16928496
17Proteasome_Homo sapiens_hsa030502.13884639
18* Viral carcinogenesis_Homo sapiens_hsa052032.02912151
19Non-homologous end-joining_Homo sapiens_hsa034501.94366056
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91720826
21Allograft rejection_Homo sapiens_hsa053301.55910721
22p53 signaling pathway_Homo sapiens_hsa041151.46750935
23Autoimmune thyroid disease_Homo sapiens_hsa053201.45870165
24RNA degradation_Homo sapiens_hsa030181.41719154
25Basal transcription factors_Homo sapiens_hsa030221.35116883
26Graft-versus-host disease_Homo sapiens_hsa053321.31908337
27mRNA surveillance pathway_Homo sapiens_hsa030151.26411383
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24891014
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22829055
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22774089
31Purine metabolism_Homo sapiens_hsa002301.16802389
32Protein export_Homo sapiens_hsa030601.15598739
33Type I diabetes mellitus_Homo sapiens_hsa049401.05855233
34Viral myocarditis_Homo sapiens_hsa054160.95155538
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87826419
36Folate biosynthesis_Homo sapiens_hsa007900.85082289
37B cell receptor signaling pathway_Homo sapiens_hsa046620.83771521
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80457326
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80421718
40Sulfur relay system_Homo sapiens_hsa041220.76012479
41Epstein-Barr virus infection_Homo sapiens_hsa051690.75976418
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72553320
43Selenocompound metabolism_Homo sapiens_hsa004500.72163266
44Herpes simplex infection_Homo sapiens_hsa051680.65897107
45Oocyte meiosis_Homo sapiens_hsa041140.65866527
46Vitamin B6 metabolism_Homo sapiens_hsa007500.65801036
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65464147
48Huntingtons disease_Homo sapiens_hsa050160.64186377
49Pentose phosphate pathway_Homo sapiens_hsa000300.62387466
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61800790
51HTLV-I infection_Homo sapiens_hsa051660.58461138
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58059807
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56309957
54Parkinsons disease_Homo sapiens_hsa050120.55450851
55Leishmaniasis_Homo sapiens_hsa051400.55033242
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54808960
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.53590120
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53191489
59Antigen processing and presentation_Homo sapiens_hsa046120.49799967
60N-Glycan biosynthesis_Homo sapiens_hsa005100.47133097
61Pyruvate metabolism_Homo sapiens_hsa006200.44655980
62Small cell lung cancer_Homo sapiens_hsa052220.43691601
63Glutathione metabolism_Homo sapiens_hsa004800.42386699
64MicroRNAs in cancer_Homo sapiens_hsa052060.41825703
65Primary immunodeficiency_Homo sapiens_hsa053400.41719937
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41261009
67Biosynthesis of amino acids_Homo sapiens_hsa012300.40802506
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.40307642
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38123377
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37554879
71Apoptosis_Homo sapiens_hsa042100.37513387
72Oxidative phosphorylation_Homo sapiens_hsa001900.36385358
73Influenza A_Homo sapiens_hsa051640.35164067
74Hematopoietic cell lineage_Homo sapiens_hsa046400.34263772
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.32986079
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30326367
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30260008
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.28192490
79Staphylococcus aureus infection_Homo sapiens_hsa051500.27782464
80Metabolic pathways_Homo sapiens_hsa011000.27015741
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26801747
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23657781
83Basal cell carcinoma_Homo sapiens_hsa052170.22805932
84Bladder cancer_Homo sapiens_hsa052190.22101489
85Hepatitis B_Homo sapiens_hsa051610.20407589
86Shigellosis_Homo sapiens_hsa051310.19422318
87Rheumatoid arthritis_Homo sapiens_hsa053230.18570062
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17772400
89Measles_Homo sapiens_hsa051620.17580915
90Galactose metabolism_Homo sapiens_hsa000520.17023798
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16592296
92Legionellosis_Homo sapiens_hsa051340.16563578
93Steroid biosynthesis_Homo sapiens_hsa001000.16556628
94Fatty acid elongation_Homo sapiens_hsa000620.15764704
95Sulfur metabolism_Homo sapiens_hsa009200.15600866
96Propanoate metabolism_Homo sapiens_hsa006400.15316714
97Platelet activation_Homo sapiens_hsa046110.14777406
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.14408847
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13457925
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.13413833
101Chronic myeloid leukemia_Homo sapiens_hsa052200.13368127
102Carbon metabolism_Homo sapiens_hsa012000.13265398
103Alzheimers disease_Homo sapiens_hsa050100.12864716
104Thyroid cancer_Homo sapiens_hsa052160.11532172
105Lysine degradation_Homo sapiens_hsa003100.11477938
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10684116
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.10526916
108Pancreatic cancer_Homo sapiens_hsa052120.10279474
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.08483424
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.08270862
111Phenylalanine metabolism_Homo sapiens_hsa003600.08176041
112Notch signaling pathway_Homo sapiens_hsa043300.07829933
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.06620830
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.06332466
115Fructose and mannose metabolism_Homo sapiens_hsa000510.05295913
116Pathways in cancer_Homo sapiens_hsa052000.05089270
117Toxoplasmosis_Homo sapiens_hsa051450.04699096
118Renin-angiotensin system_Homo sapiens_hsa046140.03503126
119Arginine and proline metabolism_Homo sapiens_hsa003300.02098684
120Malaria_Homo sapiens_hsa051440.01687066
121Linoleic acid metabolism_Homo sapiens_hsa005910.01683327
122Arachidonic acid metabolism_Homo sapiens_hsa005900.01533568
123Colorectal cancer_Homo sapiens_hsa05210-0.0360396
124Vitamin digestion and absorption_Homo sapiens_hsa04977-0.0344599
125PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0273920
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0220809
127Hippo signaling pathway_Homo sapiens_hsa04390-0.0196167
128Prostate cancer_Homo sapiens_hsa05215-0.0185725
129Non-small cell lung cancer_Homo sapiens_hsa05223-0.0174634
130Sphingolipid metabolism_Homo sapiens_hsa00600-0.0112024
131Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.0107552
132Ether lipid metabolism_Homo sapiens_hsa00565-0.0082724
133Asthma_Homo sapiens_hsa05310-0.0009911

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