HIST1H4J

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin assembly (GO:0031497)8.16525445
2regulation of histone H3-K9 methylation (GO:0051570)7.63293797
3nucleosome assembly (GO:0006334)7.53442467
4nucleosome organization (GO:0034728)6.50187767
5protein-DNA complex assembly (GO:0065004)6.36999132
6DNA unwinding involved in DNA replication (GO:0006268)6.20145410
7chromatin assembly or disassembly (GO:0006333)6.10133706
8mitotic chromosome condensation (GO:0007076)6.09849153
9antibacterial humoral response (GO:0019731)6.03892978
10nuclear pore complex assembly (GO:0051292)5.97931638
11nuclear pore organization (GO:0006999)5.87941944
12innate immune response in mucosa (GO:0002227)5.70048719
13protein-DNA complex subunit organization (GO:0071824)5.68569461
14antimicrobial humoral response (GO:0019730)5.60488793
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.57370116
16protein localization to kinetochore (GO:0034501)5.42272853
17peptidyl-lysine dimethylation (GO:0018027)5.34771251
18sister chromatid segregation (GO:0000819)5.03940589
19protein localization to chromosome, centromeric region (GO:0071459)4.61580713
20maturation of SSU-rRNA (GO:0030490)4.61434952
21pore complex assembly (GO:0046931)4.55272894
22chromatin remodeling at centromere (GO:0031055)4.53064144
23folic acid-containing compound biosynthetic process (GO:0009396)4.52914981
24regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.49641105
25CENP-A containing nucleosome assembly (GO:0034080)4.45982264
26mucosal immune response (GO:0002385)4.36534394
27DNA duplex unwinding (GO:0032508)4.18613234
28chromosome condensation (GO:0030261)4.18531694
29DNA geometric change (GO:0032392)4.18151611
30regulation of gene silencing (GO:0060968)4.16946615
31negative regulation of histone methylation (GO:0031061)4.16874676
32negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.12338091
33organ or tissue specific immune response (GO:0002251)4.11564731
34mitotic sister chromatid segregation (GO:0000070)4.09077224
35DNA topological change (GO:0006265)4.07480443
36DNA replication-independent nucleosome organization (GO:0034724)4.06177037
37DNA replication-independent nucleosome assembly (GO:0006336)4.06177037
38DNA replication initiation (GO:0006270)4.04030958
39translesion synthesis (GO:0019985)3.95422386
40mitotic sister chromatid cohesion (GO:0007064)3.92946575
41mitotic nuclear envelope disassembly (GO:0007077)3.92359604
42regulation of centriole replication (GO:0046599)3.88440957
43membrane disassembly (GO:0030397)3.79897484
44nuclear envelope disassembly (GO:0051081)3.79897484
45histone exchange (GO:0043486)3.78587505
46positive regulation of chromosome segregation (GO:0051984)3.75694438
47protein K6-linked ubiquitination (GO:0085020)3.75688299
48regulation of RNA export from nucleus (GO:0046831)3.75122769
49dosage compensation (GO:0007549)3.71492393
50regulation of sister chromatid cohesion (GO:0007063)3.68699493
51positive regulation of histone methylation (GO:0031062)3.66536711
52DNA strand elongation involved in DNA replication (GO:0006271)3.65513067
53IMP biosynthetic process (GO:0006188)3.64460505
54regulation of megakaryocyte differentiation (GO:0045652)3.62321762
55positive regulation of mitotic sister chromatid separation (GO:1901970)3.61819578
56positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.61819578
57positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.61819578
58mitotic recombination (GO:0006312)3.60889074
59DNA packaging (GO:0006323)3.56750953
60regulation of translational fidelity (GO:0006450)3.55033964
61DNA conformation change (GO:0071103)3.53908274
62histone lysine demethylation (GO:0070076)3.52988277
63ribosomal small subunit assembly (GO:0000028)3.52184526
64regulation of centrosome cycle (GO:0046605)3.50804703
65DNA strand elongation (GO:0022616)3.45512340
66kinetochore organization (GO:0051383)3.41817862
67histone demethylation (GO:0016577)3.41164154
68ATP-dependent chromatin remodeling (GO:0043044)3.41091475
69double-strand break repair via nonhomologous end joining (GO:0006303)3.35902070
70non-recombinational repair (GO:0000726)3.35902070
71somatic diversification of immune receptors via somatic mutation (GO:0002566)3.35389319
72somatic hypermutation of immunoglobulin genes (GO:0016446)3.35389319
73telomere maintenance via semi-conservative replication (GO:0032201)3.33996609
74postreplication repair (GO:0006301)3.33905277
75IMP metabolic process (GO:0046040)3.32244419
76regulation of helicase activity (GO:0051095)3.31722730
77defense response to Gram-positive bacterium (GO:0050830)3.29854937
78meiotic chromosome segregation (GO:0045132)3.26220838
79protoporphyrinogen IX metabolic process (GO:0046501)3.25620056
80regulation of chromosome segregation (GO:0051983)3.25211211
81protoporphyrinogen IX biosynthetic process (GO:0006782)3.23603410
82regulation of centrosome duplication (GO:0010824)3.21527786
83attachment of spindle microtubules to kinetochore (GO:0008608)3.19560527
84negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.18042760
85regulation of histone methylation (GO:0031060)3.17837772
86V(D)J recombination (GO:0033151)3.17402104
87regulation of posttranscriptional gene silencing (GO:0060147)3.17371578
88regulation of gene silencing by miRNA (GO:0060964)3.17371578
89regulation of gene silencing by RNA (GO:0060966)3.17371578
90protein localization to chromosome (GO:0034502)3.16587306
91imidazole-containing compound metabolic process (GO:0052803)3.15936044
92negative regulation of chromosome segregation (GO:0051985)3.12147017
93spindle checkpoint (GO:0031577)3.11223632
94resolution of meiotic recombination intermediates (GO:0000712)3.09850877
95regulation of mammary gland epithelial cell proliferation (GO:0033599)3.09662934
96spliceosomal tri-snRNP complex assembly (GO:0000244)3.08616836
97regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.08439848
98telomere maintenance via recombination (GO:0000722)3.08194479
99protein dealkylation (GO:0008214)3.04751540
100protein demethylation (GO:0006482)3.04751540
101regulation of sister chromatid segregation (GO:0033045)3.00606264
102regulation of mitotic sister chromatid separation (GO:0010965)3.00606264
103regulation of mitotic sister chromatid segregation (GO:0033047)3.00606264
104telomere maintenance (GO:0000723)2.99327704
105regulation of mitotic metaphase/anaphase transition (GO:0030071)2.99267506
106maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.97819913
107spindle assembly checkpoint (GO:0071173)2.97157433
108negative regulation of mitotic sister chromatid separation (GO:2000816)2.96607934
109negative regulation of sister chromatid segregation (GO:0033046)2.96607934
110negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96607934
111negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.96607934
112negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96607934
113chromosome segregation (GO:0007059)2.96335904
114negative regulation of DNA repair (GO:0045738)2.95698986
115regulation of spindle organization (GO:0090224)2.95596806
116viral mRNA export from host cell nucleus (GO:0046784)2.95559802
117telomere organization (GO:0032200)2.95467400
118DNA synthesis involved in DNA repair (GO:0000731)2.95117499
119pre-miRNA processing (GO:0031054)2.95006326
120nucleotide-excision repair, DNA gap filling (GO:0006297)2.94126032
121mitotic spindle assembly checkpoint (GO:0007094)2.92711139
122urea cycle (GO:0000050)2.90907764
123regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.90700614
124nuclear envelope organization (GO:0006998)2.90073680
125metaphase plate congression (GO:0051310)2.89745450
126microtubule depolymerization (GO:0007019)2.89328259
127regulation of double-strand break repair via homologous recombination (GO:0010569)2.89209869
128spindle assembly involved in mitosis (GO:0090307)2.89162721
129replication fork processing (GO:0031297)2.88836308
130intra-S DNA damage checkpoint (GO:0031573)2.85675613
131telomere maintenance via telomere lengthening (GO:0010833)2.84314929
132peptidyl-arginine omega-N-methylation (GO:0035247)2.82829058
133DNA replication-dependent nucleosome assembly (GO:0006335)10.2150263
134DNA replication-dependent nucleosome organization (GO:0034723)10.2150263

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.09411345
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.65955925
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.37151039
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.10142423
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.31716942
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.96349195
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.39081363
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.33620927
9MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.23553476
10* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.07398217
11SOX2_16153702_ChIP-ChIP_HESCs_Human2.07084882
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.01665600
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse16.8333485
14NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93961861
15* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.85114231
16MYC_18555785_ChIP-Seq_MESCs_Mouse1.76320984
17* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.75030739
18* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.72382735
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59010662
20* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58980237
21POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58209660
22IRF1_19129219_ChIP-ChIP_H3396_Human1.58064388
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57887768
24HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.44773803
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44616425
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.42705585
27* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40405980
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39913345
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.37557090
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37297533
31* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.35483753
32HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.35390097
33AR_21909140_ChIP-Seq_LNCAP_Human1.31021059
34ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30417461
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29585182
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29121698
37* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28439566
38* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27460142
39* VDR_23849224_ChIP-Seq_CD4+_Human1.23846018
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22243988
41* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21694206
42TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18376962
43NANOG_16153702_ChIP-ChIP_HESCs_Human1.17432895
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14085450
45ELK1_19687146_ChIP-ChIP_HELA_Human1.13922814
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09682984
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09036787
48* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.05756362
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02599846
50* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98719672
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96123239
52MYC_22102868_ChIP-Seq_BL_Human0.95317655
53STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94118569
54PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93650893
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91875565
56MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90110725
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89844454
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.89080689
59XRN2_22483619_ChIP-Seq_HELA_Human0.88453614
60* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87947016
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86936695
62FOXP3_21729870_ChIP-Seq_TREG_Human0.86466419
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85088445
64STAT4_19710469_ChIP-ChIP_TH1__Mouse0.84134313
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84130580
66NANOG_18555785_ChIP-Seq_MESCs_Mouse0.83672575
67MYCN_18555785_ChIP-Seq_MESCs_Mouse0.83533901
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83489500
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80956725
70ZFX_18555785_ChIP-Seq_MESCs_Mouse0.79717977
71PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78730861
72* CREB1_15753290_ChIP-ChIP_HEK293T_Human0.78211324
73DCP1A_22483619_ChIP-Seq_HELA_Human0.77502449
74* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.77270871
75THAP11_20581084_ChIP-Seq_MESCs_Mouse0.77250110
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.77078867
77* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.76956655
78CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76558726
79* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.76325144
80JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.72520190
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.71695062
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.69824704
83E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.69287598
84KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.69197323
85VDR_21846776_ChIP-Seq_THP-1_Human0.68723897
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.67857554
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.66700926
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.66651982
89SALL4_22934838_ChIP-ChIP_CD34+_Human0.65679589
90ETS1_20019798_ChIP-Seq_JURKAT_Human0.65250120
91NANOG_21062744_ChIP-ChIP_HESCs_Human0.63489225
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.61790298
93KDM5A_27292631_Chip-Seq_BREAST_Human0.61524423
94SOX9_26525672_Chip-Seq_HEART_Mouse0.61345600
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.60795216
96CIITA_25753668_ChIP-Seq_RAJI_Human0.60747782
97PKCTHETA_26484144_Chip-Seq_BREAST_Human0.60220438
98SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.60166730
99MYC_18940864_ChIP-ChIP_HL60_Human0.59886646
100* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.59374593
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.59252558
102TTF2_22483619_ChIP-Seq_HELA_Human0.58709327
103NOTCH1_21737748_ChIP-Seq_TLL_Human0.58615000
104SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.57765157
105ELF1_17652178_ChIP-ChIP_JURKAT_Human0.56775159
106GABP_17652178_ChIP-ChIP_JURKAT_Human0.56216093
107* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.55349044
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.54674037
109CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.54284704
110GATA2_22383799_ChIP-Seq_G1ME_Mouse0.54233146
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.53965121
112GATA1_22025678_ChIP-Seq_K562_Human0.52067040
113SRF_21415370_ChIP-Seq_HL-1_Mouse0.51999693
114EST1_17652178_ChIP-ChIP_JURKAT_Human0.51379118
115* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.51353369
116FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.50882847
117* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.50501731
118MAF_26560356_Chip-Seq_TH1_Human0.49772477
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.48129893

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.90343261
2MP0010307_abnormal_tumor_latency4.08923734
3MP0003111_abnormal_nucleus_morphology3.96350265
4MP0003077_abnormal_cell_cycle3.62425846
5MP0003693_abnormal_embryo_hatching3.60673939
6MP0005623_abnormal_meninges_morphology3.29418569
7MP0010352_gastrointestinal_tract_polyps3.25961612
8MP0004957_abnormal_blastocyst_morpholog3.09491594
9MP0009697_abnormal_copulation3.04837561
10MP0010234_abnormal_vibrissa_follicle3.04665198
11MP0005645_abnormal_hypothalamus_physiol3.01977203
12MP0003705_abnormal_hypodermis_morpholog2.98139184
13MP0008057_abnormal_DNA_replication2.82732598
14MP0003123_paternal_imprinting2.76731209
15MP0005076_abnormal_cell_differentiation2.46824405
16MP0003121_genomic_imprinting2.38145226
17MP0008058_abnormal_DNA_repair2.36539074
18MP0006054_spinal_hemorrhage2.32679586
19MP0000350_abnormal_cell_proliferation2.29048374
20MP0008007_abnormal_cellular_replicative2.27021836
21MP0001730_embryonic_growth_arrest2.26578238
22MP0008932_abnormal_embryonic_tissue2.26394865
23MP0002653_abnormal_ependyma_morphology2.19593470
24MP0000537_abnormal_urethra_morphology2.17921869
25MP0005171_absent_coat_pigmentation2.08672966
26MP0001661_extended_life_span2.06009940
27MP0001849_ear_inflammation2.03945567
28MP0005083_abnormal_biliary_tract1.96172332
29MP0004197_abnormal_fetal_growth/weight/1.89282621
30MP0002009_preneoplasia1.80752014
31MP0002084_abnormal_developmental_patter1.79760648
32MP0004808_abnormal_hematopoietic_stem1.73293267
33MP0008877_abnormal_DNA_methylation1.73228363
34MP0001697_abnormal_embryo_size1.69270250
35MP0002085_abnormal_embryonic_tissue1.68404678
36MP0002086_abnormal_extraembryonic_tissu1.68256463
37MP0003763_abnormal_thymus_physiology1.63728082
38MP0001672_abnormal_embryogenesis/_devel1.63451936
39MP0005380_embryogenesis_phenotype1.63451936
40MP0003890_abnormal_embryonic-extraembry1.61653518
41MP0002080_prenatal_lethality1.60948083
42MP0003937_abnormal_limbs/digits/tail_de1.53601617
43MP0000490_abnormal_crypts_of1.51238398
44MP0003787_abnormal_imprinting1.47181858
45MP0003984_embryonic_growth_retardation1.42577385
46MP0002088_abnormal_embryonic_growth/wei1.41037255
47MP0001293_anophthalmia1.40735463
48MP0006035_abnormal_mitochondrial_morpho1.39352507
49MP0000685_abnormal_immune_system1.38501844
50MP0002019_abnormal_tumor_incidence1.35569451
51MP0000703_abnormal_thymus_morphology1.35173759
52MP0000358_abnormal_cell_content/1.33014789
53MP0003941_abnormal_skin_development1.27880241
54MP0002396_abnormal_hematopoietic_system1.27374040
55MP0000313_abnormal_cell_death1.23226256
56MP0006072_abnormal_retinal_apoptosis1.23068010
57MP0002697_abnormal_eye_size1.21449557
58MP0002166_altered_tumor_susceptibility1.21391432
59MP0002111_abnormal_tail_morphology1.18985599
60MP0000733_abnormal_muscle_development1.18308444
61MP0002092_abnormal_eye_morphology1.16856628
62MP0003879_abnormal_hair_cell1.16515735
63MP0010678_abnormal_skin_adnexa1.13046612
64MP0000569_abnormal_digit_pigmentation1.11950667
65MP0002877_abnormal_melanocyte_morpholog1.10315985
66MP0003786_premature_aging1.07252368
67MP0003567_abnormal_fetal_cardiomyocyte1.06676910
68MP0008770_decreased_survivor_rate1.05366361
69MP0009703_decreased_birth_body1.05017358
70MP0001348_abnormal_lacrimal_gland1.05003320
71MP0003718_maternal_effect1.02143483
72MP0003656_abnormal_erythrocyte_physiolo1.01130157
73MP0002006_tumorigenesis0.98342912
74MP0005187_abnormal_penis_morphology0.97079304
75MP0001286_abnormal_eye_development0.96674148
76MP0002398_abnormal_bone_marrow0.94053414
77MP0000372_irregular_coat_pigmentation0.93546215
78MP0002722_abnormal_immune_system0.93126832
79MP0009046_muscle_twitch0.92586842
80MP0004147_increased_porphyrin_level0.91415626
81MP0009053_abnormal_anal_canal0.90532256
82MP0003861_abnormal_nervous_system0.89999472
83MP0002282_abnormal_trachea_morphology0.88816205
84MP0005220_abnormal_exocrine_pancreas0.88605933
85MP0001915_intracranial_hemorrhage0.88393266
86MP0010030_abnormal_orbit_morphology0.85615546
87MP0003300_gastrointestinal_ulcer0.81752303
88MP0004185_abnormal_adipocyte_glucose0.81374939
89MP0001145_abnormal_male_reproductive0.80197812
90MP0009672_abnormal_birth_weight0.79664039
91MP0000689_abnormal_spleen_morphology0.79585232
92MP0002925_abnormal_cardiovascular_devel0.79017073
93MP0000428_abnormal_craniofacial_morphol0.78998677
94MP0000432_abnormal_head_morphology0.78059625
95MP0005621_abnormal_cell_physiology0.77516741
96MP0005503_abnormal_tendon_morphology0.77375878
97MP0005384_cellular_phenotype0.77365641
98MP0002210_abnormal_sex_determination0.75762657
99MP0001299_abnormal_eye_distance/0.75757738
100MP0001929_abnormal_gametogenesis0.75190782
101MP0004264_abnormal_extraembryonic_tissu0.73945798
102MP0005391_vision/eye_phenotype0.73691431
103MP0001800_abnormal_humoral_immune0.72573809
104MP0003935_abnormal_craniofacial_develop0.72398437
105MP0005423_abnormal_somatic_nervous0.70407845
106MP0003119_abnormal_digestive_system0.70252743
107MP0008438_abnormal_cutaneous_collagen0.67449528
108MP0004233_abnormal_muscle_weight0.67093477
109MP0002163_abnormal_gland_morphology0.66906622
110MP0000427_abnormal_hair_cycle0.66733854
111MP0003699_abnormal_female_reproductive0.65959363
112MP0000653_abnormal_sex_gland0.65307808
113MP0004947_skin_inflammation0.64988401
114MP0003115_abnormal_respiratory_system0.64985626
115MP0000015_abnormal_ear_pigmentation0.64630071
116MP0002160_abnormal_reproductive_system0.64512792
117MP0003959_abnormal_lean_body0.63445152
118MP0003566_abnormal_cell_adhesion0.62963564
119MP0001727_abnormal_embryo_implantation0.62730791
120MP0002429_abnormal_blood_cell0.62601030
121MP0002081_perinatal_lethality0.62477246
122MP0002075_abnormal_coat/hair_pigmentati0.62460951
123MP0000477_abnormal_intestine_morphology0.62249134
124MP0005266_abnormal_metabolism0.61804214
125MP0000371_diluted_coat_color0.60881337
126MP0002095_abnormal_skin_pigmentation0.60797040
127MP0005253_abnormal_eye_physiology0.60659335
128MP0000383_abnormal_hair_follicle0.59762439
129MP0003183_abnormal_peptide_metabolism0.59505687
130MP0008995_early_reproductive_senescence0.59113384
131MP0005671_abnormal_response_to0.58922726
132MP0002751_abnormal_autonomic_nervous0.58819294
133MP0003091_abnormal_cell_migration0.58183574
134MP0003283_abnormal_digestive_organ0.55202505

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.22537225
2IgM deficiency (HP:0002850)6.64163460
3Recurrent sinusitis (HP:0011108)6.00479760
4IgA deficiency (HP:0002720)5.92098540
5Colitis (HP:0002583)4.78679413
6Gastrointestinal stroma tumor (HP:0100723)4.35398879
7Rhinitis (HP:0012384)4.08716714
8Chronic hepatic failure (HP:0100626)3.99708842
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.77869923
10Short 4th metacarpal (HP:0010044)3.77869923
11Ependymoma (HP:0002888)3.63995608
12Cutaneous melanoma (HP:0012056)3.48380257
13Astrocytoma (HP:0009592)3.43954417
14Abnormality of the astrocytes (HP:0100707)3.43954417
15Recurrent bronchitis (HP:0002837)3.35353758
16Nasal polyposis (HP:0100582)3.31128646
17Autoimmune hemolytic anemia (HP:0001890)3.25172647
18Cortical dysplasia (HP:0002539)3.24615013
19Impulsivity (HP:0100710)3.21942887
20Bronchitis (HP:0012387)3.20566739
21Abnormal respiratory motile cilium physiology (HP:0012261)3.20566724
22Chromsome breakage (HP:0040012)3.18857071
23Chronic diarrhea (HP:0002028)3.17951434
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.14209146
25Abnormal number of erythroid precursors (HP:0012131)3.13765983
26Abnormal ciliary motility (HP:0012262)3.12639183
27Reticulocytopenia (HP:0001896)3.11795031
28Abnormality of chromosome stability (HP:0003220)3.11151566
29Colon cancer (HP:0003003)3.10949608
30Chronic bronchitis (HP:0004469)2.99058349
31Medulloblastoma (HP:0002885)2.95562698
32Abnormality of the labia minora (HP:0012880)2.93953616
33Bile duct proliferation (HP:0001408)2.87198067
34Abnormal biliary tract physiology (HP:0012439)2.87198067
35Recurrent otitis media (HP:0000403)2.84664992
36Agnosia (HP:0010524)2.79776908
37Lymphopenia (HP:0001888)2.75674211
38Glioma (HP:0009733)2.74547295
39Occipital encephalocele (HP:0002085)2.72850546
40Biliary tract neoplasm (HP:0100574)2.65667205
41Hypochromic microcytic anemia (HP:0004840)2.64321926
42Bronchiectasis (HP:0002110)2.64159804
43Volvulus (HP:0002580)2.63416260
44Tubular atrophy (HP:0000092)2.59926756
45Rhabdomyosarcoma (HP:0002859)2.59370434
46Abnormality of the 4th metacarpal (HP:0010012)2.59054577
47Basal cell carcinoma (HP:0002671)2.57041298
48Poikilocytosis (HP:0004447)2.55181062
49Abnormality of cells of the lymphoid lineage (HP:0012140)2.54258175
50Cafe-au-lait spot (HP:0000957)2.50800780
51Inflammation of the large intestine (HP:0002037)2.49633567
52Absent frontal sinuses (HP:0002688)2.48527303
53Thyroiditis (HP:0100646)2.48426524
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.47447054
55Abnormality of the nasal mucosa (HP:0000433)2.42866050
56Sandal gap (HP:0001852)2.37648711
57Spastic diplegia (HP:0001264)2.37595954
58Birth length less than 3rd percentile (HP:0003561)2.36848201
59Heterotopia (HP:0002282)2.34756056
60Gastrointestinal carcinoma (HP:0002672)2.33599727
61Malignant gastrointestinal tract tumors (HP:0006749)2.33599727
62Prominent nose (HP:0000448)2.33013545
63Acanthocytosis (HP:0001927)2.32107304
64Hypopigmentation of the fundus (HP:0007894)2.31975900
65Selective tooth agenesis (HP:0001592)2.31888821
66Neoplasm of the oral cavity (HP:0100649)2.31714035
67Gastrointestinal inflammation (HP:0004386)2.29128169
68Hypoplasia of the pons (HP:0012110)2.28527935
69Increased nuchal translucency (HP:0010880)2.28081874
70High pitched voice (HP:0001620)2.22864490
71Nephroblastoma (Wilms tumor) (HP:0002667)2.16860533
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.15541399
73Neoplasm of striated muscle (HP:0009728)2.12464854
74Lymphoma (HP:0002665)2.10442679
75Abnormality of the fingertips (HP:0001211)2.09742289
76Renovascular hypertension (HP:0100817)2.08848872
77Hematochezia (HP:0002573)2.08411445
78Sloping forehead (HP:0000340)2.07689477
79Myelodysplasia (HP:0002863)2.07403695
80Insomnia (HP:0100785)2.07323111
81Squamous cell carcinoma (HP:0002860)2.07117052
82Meckel diverticulum (HP:0002245)2.06569664
83Abnormality of the pons (HP:0007361)2.05774974
84Freckling (HP:0001480)2.05317757
85Small intestinal stenosis (HP:0012848)2.05290791
86Duodenal stenosis (HP:0100867)2.05290791
87Limb hypertonia (HP:0002509)2.05224764
88Subacute progressive viral hepatitis (HP:0006572)2.04946157
89Ulnar bowing (HP:0003031)2.04944824
90Abnormality of reticulocytes (HP:0004312)2.04709499
91Bell-shaped thorax (HP:0001591)2.03841774
92Conjunctival telangiectasia (HP:0000524)2.03646906
93Ovarian neoplasm (HP:0100615)1.99038013
94Cutis marmorata (HP:0000965)1.98880935
95Embryonal renal neoplasm (HP:0011794)1.98538360
96Abnormality of pyrimidine metabolism (HP:0004353)1.98267756
97Cellulitis (HP:0100658)1.98150812
98Atresia of the external auditory canal (HP:0000413)1.96198584
99Deviation of the thumb (HP:0009603)1.95317605
100Abnormality of the ileum (HP:0001549)1.95117248
101Leukopenia (HP:0001882)1.94659410
102Fibrous tissue neoplasm (HP:0012316)1.94235188
103Microvesicular hepatic steatosis (HP:0001414)1.93785825
104Neoplasm of the pancreas (HP:0002894)1.93344555
105Abnormality of the carotid arteries (HP:0005344)1.92854174
106Intestinal polyposis (HP:0200008)1.92825486
107Neoplasm of the small intestine (HP:0100833)1.92150927
108Buphthalmos (HP:0000557)1.91169927
109Poikiloderma (HP:0001029)1.89304456
110Intestinal polyp (HP:0005266)1.89136143
111Abnormality of the duodenum (HP:0002246)1.89038918
112Large earlobe (HP:0009748)1.88681614
113Aqueductal stenosis (HP:0002410)1.88647974
114Entropion (HP:0000621)1.87437545
115Aplasia/Hypoplasia of the sternum (HP:0006714)1.86614025
116Proximal placement of thumb (HP:0009623)1.85897796
117Pancreatic islet-cell hyperplasia (HP:0004510)1.85171527
118Verrucae (HP:0200043)1.84981043
119Papilloma (HP:0012740)1.84981043
120Truncal obesity (HP:0001956)1.84853231
12111 pairs of ribs (HP:0000878)1.84231905
122Microtia (HP:0008551)1.83643666
123Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.82768385
124Facial hemangioma (HP:0000329)1.81017542
125Abnormality of chromosome segregation (HP:0002916)1.80899352
126Emphysema (HP:0002097)1.79973311
127Intellectual disability, moderate (HP:0002342)1.79042681
128Missing ribs (HP:0000921)1.78862762
129Abnormality of the preputium (HP:0100587)1.78822575
130Dry hair (HP:0011359)1.78262309
131Amaurosis fugax (HP:0100576)1.77753137
132Abnormality of cells of the erythroid lineage (HP:0012130)1.77509574
133Bifid tongue (HP:0010297)1.77437891
134Abnormality of DNA repair (HP:0003254)1.76457922
135Ankyloglossia (HP:0010296)1.76096404
136B lymphocytopenia (HP:0010976)1.76066638
137Orthostatic hypotension (HP:0001278)1.76000095
138Bowel diverticulosis (HP:0005222)1.75682111
139Ectopic kidney (HP:0000086)1.75512894
140Angiofibromas (HP:0010615)1.75266041
141Adenoma sebaceum (HP:0009720)1.75266041
142Hypoplasia of the thymus (HP:0000778)1.74288787
143Pelvic girdle muscle weakness (HP:0003749)1.74205723
144Skull defect (HP:0001362)1.73443404
145Clubbing of toes (HP:0100760)1.73297358
146Abnormality of the calcaneus (HP:0008364)1.72875273
147Abnormality of oral frenula (HP:0000190)1.70779951
148Uterine neoplasm (HP:0010784)1.70530347
149Abnormal lung lobation (HP:0002101)1.70528522
150Abnormality of the parietal bone (HP:0002696)1.70367286
151Dynein arm defect of respiratory motile cilia (HP:0012255)1.69945732
152Absent/shortened dynein arms (HP:0200106)1.69945732
153Facial cleft (HP:0002006)1.68812018
154Agammaglobulinemia (HP:0004432)1.66889036
155Onycholysis (HP:0001806)1.65085949
156Deep palmar crease (HP:0006191)1.61189834
157Arteriovenous malformation (HP:0100026)1.59660445
158Optic nerve coloboma (HP:0000588)1.57992981
159Anteriorly placed anus (HP:0001545)1.57240075
160Lower limb hyperreflexia (HP:0002395)1.56180332
161Down-sloping shoulders (HP:0200021)1.56056678
162Erythema (HP:0010783)1.54985410
163Short thumb (HP:0009778)1.54927166
164Rectal fistula (HP:0100590)1.54792789
165Rectovaginal fistula (HP:0000143)1.54792789
166Lipid accumulation in hepatocytes (HP:0006561)1.54331853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK6.37889477
2VRK13.64561813
3CDC73.04848963
4STK42.93254227
5RPS6KA52.80761462
6SCYL22.18797189
7MAP3K102.16122720
8SRPK12.08672862
9TLK110.0410613
10EEF2K1.95968940
11NEK21.91703509
12CDK91.87422479
13PKN21.67701316
14PIM11.59361064
15AURKB1.52975090
16MAP3K81.52397266
17CDK121.48368174
18CHEK21.45873180
19SMG11.45219942
20DYRK31.41569702
21WEE11.32622448
22TAF11.28649654
23BUB11.28516983
24RPS6KB21.26606959
25PKN11.24587798
26PBK1.19105191
27DAPK31.14906870
28DYRK1B1.08515479
29PASK1.05447467
30ATR1.00238543
31GRK60.92970367
32ACVR1B0.91707614
33MAP3K40.91552537
34PLK10.87348449
35TTK0.86688523
36AURKA0.85786489
37FRK0.84289806
38MELK0.82786571
39NEK10.82514489
40FLT30.79503900
41TTN0.78241488
42MAP2K70.77898585
43BRAF0.76525012
44FGFR20.75922363
45PLK30.73298091
46EPHA20.72118627
47NEK90.68399056
48CHEK10.67522360
49STK100.66568686
50CDK60.66212274
51CDK40.66102016
52CCNB10.64003977
53ATM0.63645008
54ICK0.61262304
55AKT20.57526265
56KSR10.56924341
57EIF2AK30.56295040
58CDK20.55986041
59BRD40.55337549
60CAMK1D0.53799422
61EIF2AK10.53614751
62PRPF4B0.49568020
63PIM20.47183994
64STK160.46315007
65CDK10.46039756
66PRKAA10.45770599
67LATS10.45503757
68STK30.44608746
69CAMK40.44342272
70CSNK1D0.44339967
71BTK0.44214878
72LRRK20.43913435
73BRSK20.43497554
74TGFBR10.42776387
75PTK60.42209267
76RPS6KA40.41474262
77ILK0.39142831
78FGR0.38759313
79CDK70.38448343
80ROCK10.36769684
81MAP2K40.35992986
82TRIB30.35862058
83BMPR1B0.35703969
84NME20.35404484
85MAPK110.35372941
86CSNK1G10.33762926
87PDGFRA0.32909699
88TSSK60.32422172
89MKNK10.32384167
90JAK20.32144354
91NUAK10.29800072
92ALK0.28267209
93MTOR0.27147986
94PRKDC0.27146683
95BCKDK0.26840723
96PRKCQ0.25869414
97CSNK1G30.25710123
98CDK80.24392108
99PAK10.23330117
100CSNK1A1L0.23323907
101FGFR10.22252428
102MUSK0.22069120
103RPS6KB10.21551469
104CSF1R0.20896833
105HIPK20.20868850
106MAPK140.20379098
107TESK20.20316140
108PAK40.20315268
109STK390.20194602
110ERBB30.20184638
111BMX0.19509932
112VRK20.19506207
113MAPKAPK50.19469199
114MKNK20.18347844
115EIF2AK20.17215408
116PLK40.16683677
117AKT10.16329848
118CSNK2A20.16248048
119BLK0.15450822
120MST40.15314568
121BRSK10.14771383
122NLK0.14681300
123PAK20.14469801
124AKT30.14230738
125MET0.13549721
126RET0.13115634
127YES10.13044551
128FGFR30.13030142
129NEK60.12388737
130CLK10.11814694
131RAF10.11414866
132SYK0.11329608
133RPS6KC10.11117538
134RPS6KL10.11117538
135RPS6KA30.10974045
136IRAK40.10947681
137PRKCI0.09938271
138RPS6KA60.08290574

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.79812136
2* Viral carcinogenesis_Homo sapiens_hsa052033.38863815
3DNA replication_Homo sapiens_hsa030302.53186724
4Mismatch repair_Homo sapiens_hsa034302.28396027
5* Systemic lupus erythematosus_Homo sapiens_hsa0532211.7804763
6Transcriptional misregulation in cancer_Homo sapiens_hsa052021.94296658
7Cell cycle_Homo sapiens_hsa041101.84600378
8One carbon pool by folate_Homo sapiens_hsa006701.77975715
9Non-homologous end-joining_Homo sapiens_hsa034501.64461738
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61769837
11RNA transport_Homo sapiens_hsa030131.47788774
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47093972
13Nucleotide excision repair_Homo sapiens_hsa034201.32312476
14Spliceosome_Homo sapiens_hsa030401.32136299
15Fanconi anemia pathway_Homo sapiens_hsa034601.31976597
16Base excision repair_Homo sapiens_hsa034101.29191830
17Homologous recombination_Homo sapiens_hsa034401.16224954
18mRNA surveillance pathway_Homo sapiens_hsa030151.06101978
19Ribosome_Homo sapiens_hsa030100.96418275
20p53 signaling pathway_Homo sapiens_hsa041150.95987228
21Primary immunodeficiency_Homo sapiens_hsa053400.91385662
22MicroRNAs in cancer_Homo sapiens_hsa052060.91106618
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85504560
24Selenocompound metabolism_Homo sapiens_hsa004500.81503660
25Chronic myeloid leukemia_Homo sapiens_hsa052200.79008124
26Intestinal immune network for IgA production_Homo sapiens_hsa046720.78339726
27Small cell lung cancer_Homo sapiens_hsa052220.77945134
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77545583
29Non-small cell lung cancer_Homo sapiens_hsa052230.68461725
30mTOR signaling pathway_Homo sapiens_hsa041500.64234009
31Colorectal cancer_Homo sapiens_hsa052100.63824671
32HTLV-I infection_Homo sapiens_hsa051660.62052196
33RNA degradation_Homo sapiens_hsa030180.60415677
34Oocyte meiosis_Homo sapiens_hsa041140.59275903
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58957521
36Pyrimidine metabolism_Homo sapiens_hsa002400.58344955
37Asthma_Homo sapiens_hsa053100.54432371
38Central carbon metabolism in cancer_Homo sapiens_hsa052300.53140333
39Allograft rejection_Homo sapiens_hsa053300.52162369
40Bladder cancer_Homo sapiens_hsa052190.52001778
41Autoimmune thyroid disease_Homo sapiens_hsa053200.51276003
42Epstein-Barr virus infection_Homo sapiens_hsa051690.51152050
43Glioma_Homo sapiens_hsa052140.46246820
44Lysine degradation_Homo sapiens_hsa003100.45093172
45Pancreatic cancer_Homo sapiens_hsa052120.44792331
46Apoptosis_Homo sapiens_hsa042100.44230140
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43710746
48Antigen processing and presentation_Homo sapiens_hsa046120.42979589
49Herpes simplex infection_Homo sapiens_hsa051680.40993743
50Carbon metabolism_Homo sapiens_hsa012000.40215193
51Hepatitis B_Homo sapiens_hsa051610.39109257
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38485394
53Endometrial cancer_Homo sapiens_hsa052130.38299199
54B cell receptor signaling pathway_Homo sapiens_hsa046620.36689883
55Renin-angiotensin system_Homo sapiens_hsa046140.36423864
56Prostate cancer_Homo sapiens_hsa052150.35846129
57Graft-versus-host disease_Homo sapiens_hsa053320.35369679
58Hedgehog signaling pathway_Homo sapiens_hsa043400.35041809
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34160291
60RNA polymerase_Homo sapiens_hsa030200.33744405
61FoxO signaling pathway_Homo sapiens_hsa040680.33489101
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33047556
63Huntingtons disease_Homo sapiens_hsa050160.31816032
64Proteoglycans in cancer_Homo sapiens_hsa052050.31252192
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28097070
66Basal transcription factors_Homo sapiens_hsa030220.27863983
67Type I diabetes mellitus_Homo sapiens_hsa049400.27839553
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26687924
69Biosynthesis of amino acids_Homo sapiens_hsa012300.26193051
70TGF-beta signaling pathway_Homo sapiens_hsa043500.26124353
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26090636
72Melanoma_Homo sapiens_hsa052180.25598207
73Thyroid cancer_Homo sapiens_hsa052160.25369733
74Hippo signaling pathway_Homo sapiens_hsa043900.24760979
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24737584
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24595952
77Pyruvate metabolism_Homo sapiens_hsa006200.24006220
78Viral myocarditis_Homo sapiens_hsa054160.23960035
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21576003
80Basal cell carcinoma_Homo sapiens_hsa052170.20450438
81Arginine biosynthesis_Homo sapiens_hsa002200.19609733
82N-Glycan biosynthesis_Homo sapiens_hsa005100.19517494
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.19322272
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19049947
85Pathways in cancer_Homo sapiens_hsa052000.17227077
86Inositol phosphate metabolism_Homo sapiens_hsa005620.16745185
87Measles_Homo sapiens_hsa051620.16744926
88Purine metabolism_Homo sapiens_hsa002300.16671808
89Adherens junction_Homo sapiens_hsa045200.16628928
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.16522006
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16476321
92Fructose and mannose metabolism_Homo sapiens_hsa000510.16448852
93AMPK signaling pathway_Homo sapiens_hsa041520.16271495
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16149955
95Legionellosis_Homo sapiens_hsa051340.16006930
96Sulfur relay system_Homo sapiens_hsa041220.15988107
97Tight junction_Homo sapiens_hsa045300.15861679
98Hematopoietic cell lineage_Homo sapiens_hsa046400.15861601
99Focal adhesion_Homo sapiens_hsa045100.14949849
100Notch signaling pathway_Homo sapiens_hsa043300.14614911
101Type II diabetes mellitus_Homo sapiens_hsa049300.14414347
102HIF-1 signaling pathway_Homo sapiens_hsa040660.14277737
103Pentose phosphate pathway_Homo sapiens_hsa000300.13555799
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.13516441
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12539800
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.11804175
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.11618020
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.11535096
109ErbB signaling pathway_Homo sapiens_hsa040120.11148342
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10705728
111Propanoate metabolism_Homo sapiens_hsa006400.10685824
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.10531994
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.09902844
114Vitamin B6 metabolism_Homo sapiens_hsa007500.09781451
115Insulin resistance_Homo sapiens_hsa049310.09637411
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.09336363
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08739935
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.08530032
119Platelet activation_Homo sapiens_hsa046110.08517338
120Estrogen signaling pathway_Homo sapiens_hsa049150.08422567
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.08056752
122Glucagon signaling pathway_Homo sapiens_hsa049220.08055246
123Galactose metabolism_Homo sapiens_hsa000520.08042936
124Influenza A_Homo sapiens_hsa051640.07989026
125Toxoplasmosis_Homo sapiens_hsa051450.07703683
126Insulin signaling pathway_Homo sapiens_hsa049100.07642774
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.07369952
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.07132172
129Oxidative phosphorylation_Homo sapiens_hsa001900.06250134
130VEGF signaling pathway_Homo sapiens_hsa043700.05656761
131Parkinsons disease_Homo sapiens_hsa050120.05323500

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