HIST1H4K

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome assembly (GO:0006335)9.19129465
2DNA replication-dependent nucleosome organization (GO:0034723)9.19129465
3chromatin assembly (GO:0031497)8.67469579
4regulation of histone H3-K9 methylation (GO:0051570)7.95727334
5pyrimidine deoxyribonucleotide catabolic process (GO:0009223)7.55619645
6base-excision repair, AP site formation (GO:0006285)7.18719842
7nucleosome assembly (GO:0006334)7.16104580
8pyrimidine nucleotide catabolic process (GO:0006244)7.10722041
9nuclear pore complex assembly (GO:0051292)6.33513947
10nucleosome organization (GO:0034728)6.22672696
11nuclear pore organization (GO:0006999)6.14189441
12protein-DNA complex assembly (GO:0065004)6.01841360
13chromatin assembly or disassembly (GO:0006333)6.00444468
14ribosomal small subunit assembly (GO:0000028)5.95369363
15DNA unwinding involved in DNA replication (GO:0006268)5.84432640
16mitotic chromosome condensation (GO:0007076)5.78332157
17antibacterial humoral response (GO:0019731)5.75766386
18protein localization to kinetochore (GO:0034501)5.54599510
19antimicrobial humoral response (GO:0019730)5.47741831
20innate immune response in mucosa (GO:0002227)5.44128275
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.43366219
22protein-DNA complex subunit organization (GO:0071824)5.41539236
23maturation of SSU-rRNA (GO:0030490)5.37167915
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.17166678
25sister chromatid segregation (GO:0000819)5.14969589
26pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.98375561
27chaperone-mediated protein transport (GO:0072321)4.98009824
28viral transcription (GO:0019083)4.82048881
29pore complex assembly (GO:0046931)4.78221146
30protein localization to chromosome, centromeric region (GO:0071459)4.70630930
31translational termination (GO:0006415)4.67882149
32negative regulation of histone methylation (GO:0031061)4.51366260
33mitotic sister chromatid segregation (GO:0000070)4.46830063
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.44667264
35ribosomal large subunit biogenesis (GO:0042273)4.33873274
36folic acid-containing compound biosynthetic process (GO:0009396)4.31243792
37deoxyribonucleotide catabolic process (GO:0009264)4.31225324
38mucosal immune response (GO:0002385)4.23848930
39DNA replication initiation (GO:0006270)4.21287503
40axonemal dynein complex assembly (GO:0070286)4.18050563
41inner mitochondrial membrane organization (GO:0007007)4.18012119
42DNA duplex unwinding (GO:0032508)4.16110382
43chromatin remodeling at centromere (GO:0031055)4.15189137
44regulation of centriole replication (GO:0046599)4.14307554
45DNA geometric change (GO:0032392)4.14194719
46energy coupled proton transport, down electrochemical gradient (GO:0015985)4.14193138
47ATP synthesis coupled proton transport (GO:0015986)4.14193138
48deoxyribose phosphate catabolic process (GO:0046386)4.12872072
49protein K6-linked ubiquitination (GO:0085020)4.07556869
50CENP-A containing nucleosome assembly (GO:0034080)4.07320452
51SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.05758541
52chromosome condensation (GO:0030261)4.05663722
53positive regulation of chromosome segregation (GO:0051984)4.01208108
54organ or tissue specific immune response (GO:0002251)3.99889555
55mitotic nuclear envelope disassembly (GO:0007077)3.99561405
56mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.99240903
57regulation of gene silencing (GO:0060968)3.97562585
58establishment of protein localization to mitochondrial membrane (GO:0090151)3.96966649
59cotranslational protein targeting to membrane (GO:0006613)3.96567790
60positive regulation of mitotic sister chromatid separation (GO:1901970)3.96558512
61positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.96558512
62positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.96558512
63translational elongation (GO:0006414)3.92622391
64protein targeting to ER (GO:0045047)3.92265262
65regulation of sister chromatid cohesion (GO:0007063)3.83670714
66membrane disassembly (GO:0030397)3.83008253
67nuclear envelope disassembly (GO:0051081)3.83008253
68cellular protein complex disassembly (GO:0043624)3.82449019
69mitotic sister chromatid cohesion (GO:0007064)3.82439577
70ribosomal small subunit biogenesis (GO:0042274)3.73079192
71DNA strand elongation involved in DNA replication (GO:0006271)3.71947316
72dosage compensation (GO:0007549)3.71550991
73DNA replication-independent nucleosome organization (GO:0034724)3.70090650
74DNA replication-independent nucleosome assembly (GO:0006336)3.70090650
75establishment of protein localization to endoplasmic reticulum (GO:0072599)3.70001962
76nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.68167444
77regulation of centrosome cycle (GO:0046605)3.66585825
78IMP biosynthetic process (GO:0006188)3.66139869
79regulation of mitochondrial translation (GO:0070129)3.65987269
80positive regulation of histone methylation (GO:0031062)3.64387830
81regulation of megakaryocyte differentiation (GO:0045652)3.63166397
82protein localization to endoplasmic reticulum (GO:0070972)3.62554817
83negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.57536803
84protein complex biogenesis (GO:0070271)3.54725822
85translesion synthesis (GO:0019985)3.54580919
86kinetochore organization (GO:0051383)3.53430745
87histone exchange (GO:0043486)3.52780594
88mitotic recombination (GO:0006312)3.52207121
89DNA topological change (GO:0006265)3.51965773
90regulation of translational fidelity (GO:0006450)3.51455590
91DNA strand elongation (GO:0022616)3.49934248
92DNA packaging (GO:0006323)3.48431385
93DNA conformation change (GO:0071103)3.47850527
94viral life cycle (GO:0019058)3.46134799
95cilium or flagellum-dependent cell motility (GO:0001539)3.44616214
96protein complex disassembly (GO:0043241)3.44438075
97regulation of gene silencing by RNA (GO:0060966)3.43869216
98regulation of posttranscriptional gene silencing (GO:0060147)3.43869216
99regulation of gene silencing by miRNA (GO:0060964)3.43869216
100meiotic chromosome segregation (GO:0045132)3.40211195
101regulation of helicase activity (GO:0051095)3.40010624
102regulation of RNA export from nucleus (GO:0046831)3.39889829
103regulation of centrosome duplication (GO:0010824)3.38826568
104regulation of DNA endoreduplication (GO:0032875)3.37001050
105translational initiation (GO:0006413)3.36481353
106telomere maintenance via semi-conservative replication (GO:0032201)3.35919473
107negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.35136402
108attachment of spindle microtubules to kinetochore (GO:0008608)3.34735328
109mitochondrial respiratory chain complex assembly (GO:0033108)3.33835405
110regulation of chromosome segregation (GO:0051983)3.32420929
111IMP metabolic process (GO:0046040)3.30334069
112macromolecular complex disassembly (GO:0032984)3.30202934
113microtubule depolymerization (GO:0007019)3.29935947
1142-deoxyribonucleotide metabolic process (GO:0009394)3.29181502
115regulation of cilium movement (GO:0003352)3.27900012
116mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.26893456
117postreplication repair (GO:0006301)3.26383942
118cell proliferation in forebrain (GO:0021846)3.25599868
119DNA synthesis involved in DNA repair (GO:0000731)3.25456991
120ATP-dependent chromatin remodeling (GO:0043044)3.23186904
121regulation of histone methylation (GO:0031060)3.21211084
122regulation of spindle organization (GO:0090224)3.20958516
123protein localization to chromosome (GO:0034502)3.20749200
124negative regulation of transcription regulatory region DNA binding (GO:2000678)3.19352720
125mitochondrial respiratory chain complex I assembly (GO:0032981)3.18564362
126NADH dehydrogenase complex assembly (GO:0010257)3.18564362
127mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.18564362
128intraciliary transport (GO:0042073)3.15516303
129base-excision repair (GO:0006284)3.14824806
130deoxyribose phosphate metabolic process (GO:0019692)3.11501400
131telomere maintenance via recombination (GO:0000722)3.10924641
132epithelial cilium movement (GO:0003351)3.09043911
133chromosome segregation (GO:0007059)3.08258585
134spindle checkpoint (GO:0031577)3.08095769
135pre-miRNA processing (GO:0031054)3.05893737
136histone lysine demethylation (GO:0070076)3.05489136
137spindle assembly involved in mitosis (GO:0090307)3.04743468
138regulation of mitotic metaphase/anaphase transition (GO:0030071)3.04375680
139response to UV-C (GO:0010225)3.03788098
140GTP biosynthetic process (GO:0006183)3.01957167
141negative regulation of DNA repair (GO:0045738)3.01921134
142histone demethylation (GO:0016577)2.97875785
143establishment of integrated proviral latency (GO:0075713)2.96814673
144regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.95936500
145proteasome assembly (GO:0043248)2.94070908
146mitotic DNA integrity checkpoint (GO:0044774)2.93951699
147mitotic metaphase plate congression (GO:0007080)2.93641246
148somatic hypermutation of immunoglobulin genes (GO:0016446)2.93201344
149somatic diversification of immune receptors via somatic mutation (GO:0002566)2.93201344
150metaphase plate congression (GO:0051310)2.93124276
151substrate-independent telencephalic tangential migration (GO:0021826)2.92644840
152substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.92644840
153heterochromatin organization (GO:0070828)2.92432319
154organelle disassembly (GO:1903008)2.92072588
155telomere maintenance (GO:0000723)2.91434474
156spindle assembly checkpoint (GO:0071173)2.91292619
157respiratory electron transport chain (GO:0022904)2.89090545
158kinetochore assembly (GO:0051382)2.87332248
159UTP biosynthetic process (GO:0006228)2.84580697
160water-soluble vitamin biosynthetic process (GO:0042364)2.82837300
161electron transport chain (GO:0022900)2.82371294
162negative regulation of DNA-templated transcription, elongation (GO:0032785)2.81980395
163protein polyglutamylation (GO:0018095)2.80947273
164nuclear-transcribed mRNA catabolic process (GO:0000956)2.78822492
165translation (GO:0006412)2.78725868
166DNA replication checkpoint (GO:0000076)2.77185157
167deoxyribonucleotide metabolic process (GO:0009262)2.77107868
168cellular component biogenesis (GO:0044085)2.76487405
169spliceosomal snRNP assembly (GO:0000387)2.74549089
170ribonucleoprotein complex biogenesis (GO:0022613)2.65125687
171urogenital system development (GO:0001655)2.64920980
172purine nucleoside triphosphate biosynthetic process (GO:0009145)2.64230394
173DNA strand renaturation (GO:0000733)2.63767473
174oxidative phosphorylation (GO:0006119)2.63356106
175nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.62972369
176guanosine-containing compound biosynthetic process (GO:1901070)2.62971439
177protein neddylation (GO:0045116)2.62742710

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.46724948
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.57443149
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.44519011
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.06619449
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.56857230
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.16234219
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.02355360
8* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.91967776
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.81757885
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.36494785
11* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25651099
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.21143047
13MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.20970573
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.06790457
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.03575780
16* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.03413734
17SOX2_16153702_ChIP-ChIP_HESCs_Human2.02761539
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse16.9742583
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.88339723
20NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83293834
21CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.82001920
22ZNF274_21170338_ChIP-Seq_K562_Hela1.78624688
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78202141
24* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.72903765
25EZH2_22144423_ChIP-Seq_EOC_Human1.71494362
26VDR_22108803_ChIP-Seq_LS180_Human1.70474463
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.69791624
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65125348
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61968660
30* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.61465119
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57546975
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53034920
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.50564867
34AR_21909140_ChIP-Seq_LNCAP_Human1.49792193
35SOX2_18555785_ChIP-Seq_MESCs_Mouse1.48753181
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.47921094
37* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45512626
38IRF1_19129219_ChIP-ChIP_H3396_Human1.42808372
39* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42760992
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41198972
41* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35493330
42HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.35461588
43* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30709523
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30186661
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.30050576
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25879129
47DCP1A_22483619_ChIP-Seq_HELA_Human1.25021635
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23918696
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21752511
50* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20649447
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.17996228
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.17157414
53* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16705439
54NANOG_16153702_ChIP-ChIP_HESCs_Human1.16594056
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15788402
56* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15709751
57* VDR_23849224_ChIP-Seq_CD4+_Human1.12307037
58* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10885439
59ELK1_19687146_ChIP-ChIP_HELA_Human1.10879423
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.10103622
61* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06682745
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06371438
63* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04386631
64FUS_26573619_Chip-Seq_HEK293_Human1.04143452
65MYC_22102868_ChIP-Seq_BL_Human1.03866441
66GABP_19822575_ChIP-Seq_HepG2_Human1.03675756
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03150350
68TP53_22573176_ChIP-Seq_HFKS_Human1.02947070
69EWS_26573619_Chip-Seq_HEK293_Human1.02607701
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00057122
71IGF1R_20145208_ChIP-Seq_DFB_Human0.99722809
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98920663
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98366428
74* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97953855
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97165722
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96616137
77* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95803007
78RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95787561
79CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94850158
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94655151
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93009522
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91351228
83RNF2_27304074_Chip-Seq_NSC_Mouse0.91092405
84PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90737993
85TAF15_26573619_Chip-Seq_HEK293_Human0.90341491
86FOXP3_21729870_ChIP-Seq_TREG_Human0.83843605
87EZH2_27304074_Chip-Seq_ESCs_Mouse0.83595564
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.83471447
89NANOG_18555785_ChIP-Seq_MESCs_Mouse0.81935813
90BRD4_27068464_Chip-Seq_AML-cells_Mouse0.81265638
91MYC_18358816_ChIP-ChIP_MESCs_Mouse0.81071579
92* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80661135
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79942918
94* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.79078769
95EED_16625203_ChIP-ChIP_MESCs_Mouse0.79073249
96ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.77844973
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77710238
98TDRD3_21172665_ChIP-Seq_MCF-7_Human0.77658475
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.77653332
100XRN2_22483619_ChIP-Seq_HELA_Human0.77246727
101CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.76600627
102MYCN_18555785_ChIP-Seq_MESCs_Mouse0.75665006
103* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.75432696
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.75092436
105* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.73645773
106CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.73071805
107GATA1_22025678_ChIP-Seq_K562_Human0.72608903
108ZFX_18555785_ChIP-Seq_MESCs_Mouse0.72269548
109YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.70847426
110CREB1_15753290_ChIP-ChIP_HEK293T_Human0.70719693
111ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.69815928
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.69515158
113FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.69391224
114TP63_19390658_ChIP-ChIP_HaCaT_Human0.68579866
115ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.67984565
116VDR_21846776_ChIP-Seq_THP-1_Human0.67668254
117SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.67294555
118THAP11_20581084_ChIP-Seq_MESCs_Mouse0.66462271
119TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.64942412
120HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.64781930
121NANOG_21062744_ChIP-ChIP_HESCs_Human0.61305679
122SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.61075079
123KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.60340984
124* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.60149272
125SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.58552181
126* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.57840695
127* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.56994085
128GATA2_22383799_ChIP-Seq_G1ME_Mouse0.56906479
129PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.56821776
130KDM5A_27292631_Chip-Seq_BREAST_Human0.56363625
131CIITA_25753668_ChIP-Seq_RAJI_Human0.54184577
132MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.53693315
133HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.53628036
134MYC_18940864_ChIP-ChIP_HL60_Human0.53022234
135SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.52278710
136* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.51222592
137EST1_17652178_ChIP-ChIP_JURKAT_Human0.49775249
138TTF2_22483619_ChIP-Seq_HELA_Human0.49188816
139CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.49120609
140CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.48617210
141* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.48021166
142SALL4_22934838_ChIP-ChIP_CD34+_Human0.47320471
143GATA1_19941826_ChIP-Seq_K562_Human0.46916550

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.38038775
2MP0006292_abnormal_olfactory_placode5.94932835
3MP0010094_abnormal_chromosome_stability4.85041185
4MP0010307_abnormal_tumor_latency4.24000894
5MP0003111_abnormal_nucleus_morphology4.13127001
6MP0003077_abnormal_cell_cycle3.65496021
7MP0003693_abnormal_embryo_hatching3.64742343
8MP0010352_gastrointestinal_tract_polyps3.35618446
9MP0003705_abnormal_hypodermis_morpholog3.31938165
10MP0004957_abnormal_blastocyst_morpholog3.09655403
11MP0008057_abnormal_DNA_replication3.04574528
12MP0000566_synostosis2.57595874
13MP0010234_abnormal_vibrissa_follicle2.57086788
14MP0005076_abnormal_cell_differentiation2.45454147
15MP0003123_paternal_imprinting2.43679514
16MP0008058_abnormal_DNA_repair2.38535491
17MP0003315_abnormal_perineum_morphology2.36300634
18MP0006054_spinal_hemorrhage2.34384218
19MP0002938_white_spotting2.32382887
20MP0001730_embryonic_growth_arrest2.30797853
21MP0000350_abnormal_cell_proliferation2.28008876
22MP0002102_abnormal_ear_morphology2.22796642
23MP0008932_abnormal_embryonic_tissue2.20011655
24MP0008007_abnormal_cellular_replicative2.19439802
25MP0003121_genomic_imprinting2.18566404
26MP0008995_early_reproductive_senescence2.12644637
27MP0008877_abnormal_DNA_methylation2.05254139
28MP0001529_abnormal_vocalization1.93757740
29MP0004197_abnormal_fetal_growth/weight/1.91214221
30MP0004808_abnormal_hematopoietic_stem1.90888232
31MP0003656_abnormal_erythrocyte_physiolo1.88304309
32MP0008789_abnormal_olfactory_epithelium1.85866319
33MP0005646_abnormal_pituitary_gland1.82571953
34MP0002086_abnormal_extraembryonic_tissu1.76931217
35MP0002084_abnormal_developmental_patter1.75449045
36MP0000537_abnormal_urethra_morphology1.75086044
37MP0001697_abnormal_embryo_size1.71985588
38MP0001672_abnormal_embryogenesis/_devel1.64128318
39MP0005380_embryogenesis_phenotype1.64128318
40MP0002085_abnormal_embryonic_tissue1.62059721
41MP0004742_abnormal_vestibular_system1.61251199
42MP0002396_abnormal_hematopoietic_system1.60096395
43MP0009697_abnormal_copulation1.57727092
44MP0002080_prenatal_lethality1.57204435
45MP0000778_abnormal_nervous_system1.57106483
46MP0003938_abnormal_ear_development1.56460826
47MP0004147_increased_porphyrin_level1.54092601
48MP0003122_maternal_imprinting1.53689357
49MP0002019_abnormal_tumor_incidence1.46388624
50MP0005394_taste/olfaction_phenotype1.45821478
51MP0005499_abnormal_olfactory_system1.45821478
52MP0000490_abnormal_crypts_of1.45717952
53MP0003937_abnormal_limbs/digits/tail_de1.42595423
54MP0003984_embryonic_growth_retardation1.40751237
55MP0003890_abnormal_embryonic-extraembry1.39658401
56MP0002088_abnormal_embryonic_growth/wei1.39522000
57MP0003786_premature_aging1.39321713
58MP0002009_preneoplasia1.36811857
59MP0002166_altered_tumor_susceptibility1.34430008
60MP0004142_abnormal_muscle_tone1.34077676
61MP0000049_abnormal_middle_ear1.32976831
62MP0000703_abnormal_thymus_morphology1.32508182
63MP0005360_urolithiasis1.28824132
64MP0003646_muscle_fatigue1.25963756
65MP0001485_abnormal_pinna_reflex1.24243025
66MP0001293_anophthalmia1.23800231
67MP0004145_abnormal_muscle_electrophysio1.21790264
68MP0003787_abnormal_imprinting1.21250825
69MP0005623_abnormal_meninges_morphology1.21157334
70MP0005253_abnormal_eye_physiology1.20490501
71MP0000313_abnormal_cell_death1.20195739
72MP0002092_abnormal_eye_morphology1.18608946
73MP0005551_abnormal_eye_electrophysiolog1.16691966
74MP0008438_abnormal_cutaneous_collagen1.16252088
75MP0002697_abnormal_eye_size1.16007811
76MP0000631_abnormal_neuroendocrine_gland1.15478306
77MP0005670_abnormal_white_adipose1.14913377
78MP0003183_abnormal_peptide_metabolism1.14506376
79MP0002877_abnormal_melanocyte_morpholog1.12810675
80MP0001915_intracranial_hemorrhage1.12043684
81MP0002233_abnormal_nose_morphology1.10096336
82MP0000733_abnormal_muscle_development1.08710615
83MP0002722_abnormal_immune_system1.07504240
84MP0003566_abnormal_cell_adhesion1.06545266
85MP0002006_tumorigenesis1.05938585
86MP0002111_abnormal_tail_morphology1.03669053
87MP0009703_decreased_birth_body1.03382401
88MP0008770_decreased_survivor_rate1.01999929
89MP0002398_abnormal_bone_marrow1.01645128
90MP0003567_abnormal_fetal_cardiomyocyte1.00852065
91MP0002751_abnormal_autonomic_nervous1.00663450
92MP0002638_abnormal_pupillary_reflex1.00257903
93MP0000647_abnormal_sebaceous_gland0.98698537
94MP0002277_abnormal_respiratory_mucosa0.98286516
95MP0003300_gastrointestinal_ulcer0.97287800
96MP0010678_abnormal_skin_adnexa0.96471351
97MP0005084_abnormal_gallbladder_morpholo0.96128935
98MP0002095_abnormal_skin_pigmentation0.95633822
99MP0002160_abnormal_reproductive_system0.94410829
100MP0000689_abnormal_spleen_morphology0.93878812
101MP0008875_abnormal_xenobiotic_pharmacok0.93408852
102MP0000026_abnormal_inner_ear0.93244091
103MP0006276_abnormal_autonomic_nervous0.90588339
104MP0001986_abnormal_taste_sensitivity0.90316445
105MP0004133_heterotaxia0.89825849
106MP0004185_abnormal_adipocyte_glucose0.89165294
107MP0002736_abnormal_nociception_after0.89138532
108MP0001984_abnormal_olfaction0.88919861
109MP0000579_abnormal_nail_morphology0.87675026
110MP0010030_abnormal_orbit_morphology0.86984230
111MP0000427_abnormal_hair_cycle0.86664198
112MP0005621_abnormal_cell_physiology0.86433089
113MP0002925_abnormal_cardiovascular_devel0.86286893
114MP0000372_irregular_coat_pigmentation0.84817755
115MP0004233_abnormal_muscle_weight0.84648146
116MP0009672_abnormal_birth_weight0.83896039
117MP0002752_abnormal_somatic_nervous0.83184202
118MP0005195_abnormal_posterior_eye0.82013074
119MP0000428_abnormal_craniofacial_morphol0.81302982
120MP0005384_cellular_phenotype0.81192656
121MP0006072_abnormal_retinal_apoptosis0.80808897
122MP0005389_reproductive_system_phenotype0.80792550
123MP0006035_abnormal_mitochondrial_morpho0.80677165
124MP0005501_abnormal_skin_physiology0.79537684
125MP0009053_abnormal_anal_canal0.79357169
126MP0001286_abnormal_eye_development0.78900651
127MP0005023_abnormal_wound_healing0.78622770
128MP0002234_abnormal_pharynx_morphology0.78029563
129MP0003861_abnormal_nervous_system0.77725224
130MP0001905_abnormal_dopamine_level0.77580525
131MP0001849_ear_inflammation0.76472938
132MP0003091_abnormal_cell_migration0.75595943
133MP0000653_abnormal_sex_gland0.75470498
134MP0005085_abnormal_gallbladder_physiolo0.75357278
135MP0000465_gastrointestinal_hemorrhage0.73817890
136MP0000747_muscle_weakness0.73810586
137MP0001929_abnormal_gametogenesis0.72872367
138MP0005187_abnormal_penis_morphology0.72161276
139MP0000432_abnormal_head_morphology0.71914804
140MP0000569_abnormal_digit_pigmentation0.71880369
141MP0001486_abnormal_startle_reflex0.71531466
142MP0009278_abnormal_bone_marrow0.71244372
143MP0002210_abnormal_sex_determination0.70071353
144MP0001145_abnormal_male_reproductive0.69823832
145MP0003698_abnormal_male_reproductive0.69224229
146MP0003942_abnormal_urinary_system0.69209780
147MP0001764_abnormal_homeostasis0.68380890
148MP0002429_abnormal_blood_cell0.68012229
149MP0005171_absent_coat_pigmentation0.67395063
150MP0003283_abnormal_digestive_organ0.67318537
151MP0002098_abnormal_vibrissa_morphology0.66599121
152MP0001119_abnormal_female_reproductive0.66070470
153MP0001545_abnormal_hematopoietic_system0.65764379
154MP0005397_hematopoietic_system_phenotyp0.65764379
155MP0000477_abnormal_intestine_morphology0.65703841
156MP0003115_abnormal_respiratory_system0.65586595
157MP0003119_abnormal_digestive_system0.65347199
158MP0005083_abnormal_biliary_tract0.64983850
159MP0000955_abnormal_spinal_cord0.64921499
160MP0003252_abnormal_bile_duct0.63960910
161MP0005410_abnormal_fertilization0.63946018
162MP0002733_abnormal_thermal_nociception0.63392623
163MP0005377_hearing/vestibular/ear_phenot0.63043350
164MP0005391_vision/eye_phenotype0.61243172
165MP0003448_altered_tumor_morphology0.61235831
166MP0003453_abnormal_keratinocyte_physiol0.61068487
167MP0000266_abnormal_heart_morphology0.60350276
168MP0003935_abnormal_craniofacial_develop0.60099728
169MP0003303_peritoneal_inflammation0.59708029

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)4.70826099
2Abnormal respiratory epithelium morphology (HP:0012253)4.57759519
3Abnormal respiratory motile cilium morphology (HP:0005938)4.57759519
4Acute necrotizing encephalopathy (HP:0006965)3.99848677
5Poikilocytosis (HP:0004447)3.72803363
6Chromsome breakage (HP:0040012)3.66215336
7Abnormal mitochondria in muscle tissue (HP:0008316)3.62044705
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.58132544
9Acute encephalopathy (HP:0006846)3.56136862
10Hypochromic microcytic anemia (HP:0004840)3.49851924
11Cutaneous melanoma (HP:0012056)3.46529347
12Ependymoma (HP:0002888)3.39581225
13Palpebral edema (HP:0100540)3.34284243
14Abnormality of chromosome stability (HP:0003220)3.29746424
153-Methylglutaconic aciduria (HP:0003535)3.25423436
16Abnormality of the astrocytes (HP:0100707)3.23929158
17Astrocytoma (HP:0009592)3.23929158
18Mitochondrial inheritance (HP:0001427)3.22092405
19Medulloblastoma (HP:0002885)3.19832924
20Progressive macrocephaly (HP:0004481)3.17435836
21Abnormal respiratory motile cilium physiology (HP:0012261)3.17173894
22Reticulocytopenia (HP:0001896)3.15079523
23Supernumerary spleens (HP:0009799)3.03135019
24Volvulus (HP:0002580)2.97244859
25Impulsivity (HP:0100710)2.93399467
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.93265910
27Short 4th metacarpal (HP:0010044)2.93265910
28Colon cancer (HP:0003003)2.92649718
29Dynein arm defect of respiratory motile cilia (HP:0012255)2.90258332
30Absent/shortened dynein arms (HP:0200106)2.90258332
31Abnormal ciliary motility (HP:0012262)2.86695958
32Rhabdomyosarcoma (HP:0002859)2.82254165
33Agnosia (HP:0010524)2.80980240
34Increased hepatocellular lipid droplets (HP:0006565)2.79636061
35Increased CSF lactate (HP:0002490)2.78704405
36Acanthocytosis (HP:0001927)2.78097647
37Fibular aplasia (HP:0002990)2.75405738
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.71737270
39Cerebral edema (HP:0002181)2.71624386
40Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.66085323
41Biliary tract neoplasm (HP:0100574)2.64570997
42Selective tooth agenesis (HP:0001592)2.64532798
43Glioma (HP:0009733)2.64485037
44Hepatocellular necrosis (HP:0001404)2.64210948
45Sandal gap (HP:0001852)2.61714215
46Infertility (HP:0000789)2.58558345
47Ulnar bowing (HP:0003031)2.58379651
48Abnormality of reticulocytes (HP:0004312)2.56438292
49Cortical dysplasia (HP:0002539)2.53163850
50Cafe-au-lait spot (HP:0000957)2.52212385
51Abnormality of the labia minora (HP:0012880)2.51876141
52Basal cell carcinoma (HP:0002671)2.51403527
53Thyroiditis (HP:0100646)2.50103348
54Aplastic anemia (HP:0001915)2.49262754
55Pallor (HP:0000980)2.48261019
56Lipid accumulation in hepatocytes (HP:0006561)2.46929837
57Birth length less than 3rd percentile (HP:0003561)2.46373219
58Triphalangeal thumb (HP:0001199)2.45662866
59Pendular nystagmus (HP:0012043)2.45567543
60High pitched voice (HP:0001620)2.43918166
61Increased nuchal translucency (HP:0010880)2.42508517
62Hepatic necrosis (HP:0002605)2.38472162
63Bronchiectasis (HP:0002110)2.37860929
64Poor speech (HP:0002465)2.37298868
65Aplasia/Hypoplasia involving the musculature (HP:0001460)2.36678762
66Abnormality of the heme biosynthetic pathway (HP:0010472)2.32477796
67Heterotopia (HP:0002282)2.32349491
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.30327552
69Duodenal stenosis (HP:0100867)2.29143878
70Small intestinal stenosis (HP:0012848)2.29143878
71Neoplasm of the oral cavity (HP:0100649)2.28417737
72Gastrointestinal carcinoma (HP:0002672)2.27853039
73Malignant gastrointestinal tract tumors (HP:0006749)2.27853039
74Abnormality of cells of the erythroid lineage (HP:0012130)2.26652216
75Abnormal number of incisors (HP:0011064)2.24213352
76Deviation of the thumb (HP:0009603)2.24057474
77Reticulocytosis (HP:0001923)2.23452599
78Rhinitis (HP:0012384)2.23183340
79Hypopigmentation of the fundus (HP:0007894)2.22147710
80Prominent nose (HP:0000448)2.20459971
81Absent frontal sinuses (HP:0002688)2.20395882
82Meckel diverticulum (HP:0002245)2.19819420
83Squamous cell carcinoma (HP:0002860)2.19029844
84Papilloma (HP:0012740)2.16711664
85Verrucae (HP:0200043)2.16711664
86Oligodactyly (hands) (HP:0001180)2.14592639
87Anophthalmia (HP:0000528)2.14501049
88Aplasia/Hypoplasia of the fibula (HP:0006492)2.13995279
89Proximal placement of thumb (HP:0009623)2.12359330
90Fibular hypoplasia (HP:0003038)2.11970836
91Duplicated collecting system (HP:0000081)2.11802669
92Abnormality of DNA repair (HP:0003254)2.11532691
93Myelodysplasia (HP:0002863)2.10352223
94Neoplasm of striated muscle (HP:0009728)2.09783178
95Abnormality of the renal collecting system (HP:0004742)2.09746819
9611 pairs of ribs (HP:0000878)2.09524391
97Abnormality of the ileum (HP:0001549)2.09205005
98Renal Fanconi syndrome (HP:0001994)2.07953614
99Missing ribs (HP:0000921)2.07820753
100Patellar aplasia (HP:0006443)2.04004382
101Increased serum lactate (HP:0002151)2.03902462
102Spastic diplegia (HP:0001264)2.03420077
103Abnormality of the preputium (HP:0100587)2.03123310
104Sloping forehead (HP:0000340)2.01821309
105Freckling (HP:0001480)2.01612972
106Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00758180
107Abnormal protein N-linked glycosylation (HP:0012347)2.00758180
108Abnormal protein glycosylation (HP:0012346)2.00758180
109Abnormal glycosylation (HP:0012345)2.00758180
110Partial agenesis of the corpus callosum (HP:0001338)2.00637433
111Abnormality of the 4th metacarpal (HP:0010012)1.99714622
112Short thumb (HP:0009778)1.98635619
113Ovarian neoplasm (HP:0100615)1.98469493
114Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97184997
115Myokymia (HP:0002411)1.95261883
116Abnormality of the carotid arteries (HP:0005344)1.94214216
117Subacute progressive viral hepatitis (HP:0006572)1.93972842
118Amaurosis fugax (HP:0100576)1.93702755
119Lactic acidosis (HP:0003128)1.93327197
120Abnormality of the duodenum (HP:0002246)1.92106432
121Intestinal polyposis (HP:0200008)1.90748680
122Abnormality of the fingertips (HP:0001211)1.89605672
123Abnormality of the parietal bone (HP:0002696)1.89505040
124Septo-optic dysplasia (HP:0100842)1.89200428
125Atresia of the external auditory canal (HP:0000413)1.88812095
126Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88487702
127Maternal diabetes (HP:0009800)1.88134493
128Neoplasm of the pancreas (HP:0002894)1.87488462
129Abnormality of chromosome segregation (HP:0002916)1.87246794
130Aplasia/Hypoplasia of the sternum (HP:0006714)1.86437056
131Exercise intolerance (HP:0003546)1.86324395
132Absent thumb (HP:0009777)1.86282609
133Medial flaring of the eyebrow (HP:0010747)1.85386510
134Intestinal polyp (HP:0005266)1.85116647
135Nephroblastoma (Wilms tumor) (HP:0002667)1.85098807
136Cutis marmorata (HP:0000965)1.85010800
137Abnormality of the calcaneus (HP:0008364)1.84833269
138Truncal obesity (HP:0001956)1.84054681
139Abnormal lung lobation (HP:0002101)1.82873824
140Aplasia/Hypoplasia of the patella (HP:0006498)1.82469879
141Ectopic kidney (HP:0000086)1.82078917
142Renovascular hypertension (HP:0100817)1.81873709
143Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.80068591
144Premature skin wrinkling (HP:0100678)1.79984188
145Ankyloglossia (HP:0010296)1.79201740
146Macrocytic anemia (HP:0001972)1.78828998
147Molar tooth sign on MRI (HP:0002419)1.78369160
148Abnormality of midbrain morphology (HP:0002418)1.78369160
149Clubbing of toes (HP:0100760)1.78165945
150Hypochromic anemia (HP:0001931)1.77968257
151Retinal dysplasia (HP:0007973)1.77223586
152Bowel diverticulosis (HP:0005222)1.76945012
153Neoplasm of the small intestine (HP:0100833)1.76765329
154Abnormality of oral frenula (HP:0000190)1.76537124
155Hypoplasia of the thymus (HP:0000778)1.76277922
156Oligodactyly (HP:0012165)1.74961656
157Leukodystrophy (HP:0002415)1.74813888
158Ankle contracture (HP:0006466)1.74647284
159Type 2 muscle fiber atrophy (HP:0003554)1.74052499
160Abnormality of alanine metabolism (HP:0010916)1.73913126
161Hyperalaninemia (HP:0003348)1.73913126
162Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73913126
163Growth hormone deficiency (HP:0000824)1.73182497
164Embryonal renal neoplasm (HP:0011794)1.72738427
165Cerebral aneurysm (HP:0004944)1.72727173
166Hematochezia (HP:0002573)1.72133702
167Wrist flexion contracture (HP:0001239)1.72015292
168Combined immunodeficiency (HP:0005387)1.71818962
169Aqueductal stenosis (HP:0002410)1.71799587
170Abnormality of the proximal phalanges of the hand (HP:0009834)1.71142335
171Horseshoe kidney (HP:0000085)1.70517506
172Congenital, generalized hypertrichosis (HP:0004540)1.70375460
173Bilateral microphthalmos (HP:0007633)1.68126562
174Duplication of thumb phalanx (HP:0009942)1.67879116
175Short tibia (HP:0005736)1.67825070
176Synostosis of carpal bones (HP:0005048)1.67123404
177Deep palmar crease (HP:0006191)1.66691557
178Chronic bronchitis (HP:0004469)1.65913806
179Pancytopenia (HP:0001876)1.65658044

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.48274002
2ZAK6.15269177
3STK163.71366860
4VRK23.54559547
5VRK13.30377287
6CDC73.26087499
7STK43.03344887
8RPS6KA52.80771946
9MAP3K102.80248845
10EEF2K2.43562892
11NEK22.15410750
12CDK92.06736211
13SCYL21.98083346
14NUAK11.94546619
15CAMKK21.78840620
16AURKB1.68550403
17PKN21.59553471
18BUB11.59452542
19SRPK11.59131556
20MAP3K81.58651133
21DAPK31.57245874
22PIM11.56111910
23CHEK21.56014624
24WNK41.55182470
25EPHB21.54574855
26TIE11.52140377
27TAOK31.51619375
28RPS6KB21.50892538
29BCKDK1.50320756
30WEE11.47524991
31MAP2K71.42656883
32DYRK21.35874029
33TAF11.28961184
34TTK1.23983532
35CDK121.18038540
36PASK1.15208009
37PKN11.13668798
38TTN1.13644582
39MKNK21.11649813
40MAPK131.09704020
41GRK61.08989862
42ATR1.07847359
43DYRK31.06265539
44MAP3K111.05383118
45EPHA21.04670071
46WNK30.99531473
47FRK0.98650916
48PLK10.97432434
49NEK10.95929473
50MAP3K120.94088468
51EIF2AK10.93242447
52CDK40.88946776
53MELK0.88256153
54AURKA0.86348375
55ACVR1B0.84557663
56NME10.84192388
57STK100.83474703
58PLK20.82065216
59DYRK1B0.81306984
60MAP2K40.80757357
61PBK0.80017977
62PLK30.79742594
63CHEK10.77338456
64CSNK1G30.75123098
65CCNB10.74968068
66MAP3K40.71577591
67FGFR20.71346449
68ATM0.71123381
69MAP4K20.68998949
70PHKG10.67933973
71PHKG20.67933973
72IRAK10.67931310
73CDK60.66813230
74EPHA40.64317931
75TGFBR10.63351488
76CDK20.61347462
77TRIB30.60979128
78GRK70.59659467
79EIF2AK30.59039451
80CSNK1A1L0.58857671
81CAMK1D0.58223495
82DAPK20.58011952
83FLT30.57415932
84STK30.56992911
85LRRK20.56601552
86CSNK1G10.56409389
87CSNK1G20.56044651
88NME20.53799544
89AKT20.52886200
90BMPR1B0.50124361
91ERBB20.49319870
92CDK10.48575633
93BRSK20.48005976
94OBSCN0.47644001
95CSNK1D0.46032509
96PRKAA10.45673453
97TRIM280.43877480
98KSR10.43633830
99CAMKK10.42189779
100ALK0.41261332
101TXK0.40099050
102PINK10.38514366
103LATS10.38004072
104PTK60.37262579
105CSNK2A10.37155453
106UHMK10.36018949
107PDGFRA0.35824232
108MAP3K60.35702699
109RPS6KB10.34328492
110CDK70.33766418
111PRKDC0.33339359
112MTOR0.32857796
113ROCK10.32669418
114BRSK10.31217369
115EIF2AK20.31089159
116TSSK60.30116895
117WNK10.30008550
118KIT0.29338743
119CDK80.28491825
120FGR0.27287384
121PAK20.26048789
122SMG10.25792860
123PRKACB0.25506060
124JAK20.25216576
125RPS6KA40.25114024
126PIK3CG0.24662511
127PAK10.24502038
128PAK60.24016254
129CAMK10.23294011
130MINK10.23266773
131FGFR30.23086707
132CLK10.23033091
133ILK0.22620172
134MAPK140.21681421
135CDK190.21179816
136PIK3CA0.20437654
137NTRK20.20084366
138PRKCQ0.19606929
139MAPK150.19221165
140PAK40.19015781
141AKT10.19001924
142SGK10.18658491
143CSNK2A20.17702573
144TRPM70.17272729
145CSF1R0.17150582
146PLK40.14889710
147TESK10.13240928
148FGFR10.12796215
149RPS6KA30.11829259
150MKNK10.11743431
151PDGFRB0.11571697
152BMX0.09248725
153GSK3B0.08309202
154PRKCI0.08233088
155RPS6KC10.07622780
156RPS6KL10.07622780
157MET0.07609867
158INSR0.07350529

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.66781381
2* Viral carcinogenesis_Homo sapiens_hsa052033.37292647
3Oxidative phosphorylation_Homo sapiens_hsa001903.26940607
4DNA replication_Homo sapiens_hsa030302.66350650
5Parkinsons disease_Homo sapiens_hsa050122.60770297
6Mismatch repair_Homo sapiens_hsa034302.38548056
7Proteasome_Homo sapiens_hsa030502.32581647
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24654226
9Huntingtons disease_Homo sapiens_hsa050162.09958923
10* Systemic lupus erythematosus_Homo sapiens_hsa0532211.6258980
11Transcriptional misregulation in cancer_Homo sapiens_hsa052021.92609205
12Cell cycle_Homo sapiens_hsa041101.92006585
13One carbon pool by folate_Homo sapiens_hsa006701.88392550
14Non-homologous end-joining_Homo sapiens_hsa034501.79786516
15Alzheimers disease_Homo sapiens_hsa050101.69773202
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61198063
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56817309
18RNA transport_Homo sapiens_hsa030131.53651331
19Cardiac muscle contraction_Homo sapiens_hsa042601.47250995
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43180051
21Fanconi anemia pathway_Homo sapiens_hsa034601.43112576
22Nucleotide excision repair_Homo sapiens_hsa034201.38899764
23Steroid biosynthesis_Homo sapiens_hsa001001.38611636
24Base excision repair_Homo sapiens_hsa034101.35100707
25Spliceosome_Homo sapiens_hsa030401.26409241
26Homologous recombination_Homo sapiens_hsa034401.22335533
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17926230
28Caffeine metabolism_Homo sapiens_hsa002321.09898788
29mRNA surveillance pathway_Homo sapiens_hsa030151.07309520
30Protein export_Homo sapiens_hsa030601.05083000
31Ribosome_Homo sapiens_hsa030101.04377772
32Sulfur relay system_Homo sapiens_hsa041221.01871685
33MicroRNAs in cancer_Homo sapiens_hsa052060.99803314
34p53 signaling pathway_Homo sapiens_hsa041150.97482121
35Collecting duct acid secretion_Homo sapiens_hsa049660.93344560
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89721693
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86744314
38Nicotine addiction_Homo sapiens_hsa050330.86613009
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85413111
40Small cell lung cancer_Homo sapiens_hsa052220.83302759
41Nitrogen metabolism_Homo sapiens_hsa009100.81734821
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78197665
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74605531
44Selenocompound metabolism_Homo sapiens_hsa004500.72797370
45Chronic myeloid leukemia_Homo sapiens_hsa052200.71995283
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.71227439
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.71038781
48Pyruvate metabolism_Homo sapiens_hsa006200.70861047
49Linoleic acid metabolism_Homo sapiens_hsa005910.68221456
50Non-small cell lung cancer_Homo sapiens_hsa052230.67263891
51HTLV-I infection_Homo sapiens_hsa051660.65641720
52Peroxisome_Homo sapiens_hsa041460.64308520
53Oocyte meiosis_Homo sapiens_hsa041140.64019455
54Glutathione metabolism_Homo sapiens_hsa004800.62267826
55RNA degradation_Homo sapiens_hsa030180.61100832
56Pyrimidine metabolism_Homo sapiens_hsa002400.60009000
57Chemical carcinogenesis_Homo sapiens_hsa052040.58589612
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57151321
59Bladder cancer_Homo sapiens_hsa052190.57002463
60mTOR signaling pathway_Homo sapiens_hsa041500.53884282
61Butanoate metabolism_Homo sapiens_hsa006500.52628003
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52009827
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51239920
64Colorectal cancer_Homo sapiens_hsa052100.49174529
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48482474
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47907039
67Epstein-Barr virus infection_Homo sapiens_hsa051690.47581711
68Antigen processing and presentation_Homo sapiens_hsa046120.47035844
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46468877
70Metabolic pathways_Homo sapiens_hsa011000.46338679
71Glioma_Homo sapiens_hsa052140.44906359
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.44185207
73Propanoate metabolism_Homo sapiens_hsa006400.44004570
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43059270
75Herpes simplex infection_Homo sapiens_hsa051680.42069459
76Pancreatic cancer_Homo sapiens_hsa052120.41300541
77Apoptosis_Homo sapiens_hsa042100.41186725
78Taste transduction_Homo sapiens_hsa047420.40000427
79Tryptophan metabolism_Homo sapiens_hsa003800.38453312
80Asthma_Homo sapiens_hsa053100.38448341
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38222467
82Phototransduction_Homo sapiens_hsa047440.37766126
83B cell receptor signaling pathway_Homo sapiens_hsa046620.37379682
84TGF-beta signaling pathway_Homo sapiens_hsa043500.36898695
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36515971
86Lysine degradation_Homo sapiens_hsa003100.36511117
87Prostate cancer_Homo sapiens_hsa052150.36465334
88FoxO signaling pathway_Homo sapiens_hsa040680.36144598
89Folate biosynthesis_Homo sapiens_hsa007900.36143663
90Proteoglycans in cancer_Homo sapiens_hsa052050.36009512
91Hepatitis B_Homo sapiens_hsa051610.34841610
92RNA polymerase_Homo sapiens_hsa030200.34540487
93Olfactory transduction_Homo sapiens_hsa047400.30657068
94Hippo signaling pathway_Homo sapiens_hsa043900.30620952
95Vibrio cholerae infection_Homo sapiens_hsa051100.30490803
96Renin-angiotensin system_Homo sapiens_hsa046140.30179612
97Regulation of autophagy_Homo sapiens_hsa041400.29207287
98Endometrial cancer_Homo sapiens_hsa052130.28939762
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28447662
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28183007
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28020185
102Biosynthesis of amino acids_Homo sapiens_hsa012300.27743512
103Arachidonic acid metabolism_Homo sapiens_hsa005900.27722721
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26870867
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26240853
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26139199
107Fat digestion and absorption_Homo sapiens_hsa049750.25810730
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.25490230
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.25367687
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25309552
111Basal cell carcinoma_Homo sapiens_hsa052170.24977646
112Basal transcription factors_Homo sapiens_hsa030220.24487765
113Melanoma_Homo sapiens_hsa052180.24333422
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24005751
115Focal adhesion_Homo sapiens_hsa045100.23725075
116Thyroid cancer_Homo sapiens_hsa052160.23675674
117Adherens junction_Homo sapiens_hsa045200.23038638
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22627571
119Tight junction_Homo sapiens_hsa045300.22286875
120Vitamin B6 metabolism_Homo sapiens_hsa007500.22071097
121Retinol metabolism_Homo sapiens_hsa008300.21851574
122Pathways in cancer_Homo sapiens_hsa052000.21305123
123Ether lipid metabolism_Homo sapiens_hsa005650.21302571
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21088634
125Sulfur metabolism_Homo sapiens_hsa009200.20862738
126Carbon metabolism_Homo sapiens_hsa012000.20483484
127Viral myocarditis_Homo sapiens_hsa054160.20469460
128HIF-1 signaling pathway_Homo sapiens_hsa040660.20259428
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20213126
130Arginine and proline metabolism_Homo sapiens_hsa003300.19538103
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19149467
132Legionellosis_Homo sapiens_hsa051340.19090557
133AMPK signaling pathway_Homo sapiens_hsa041520.18794630
134Purine metabolism_Homo sapiens_hsa002300.18162169
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.18111801
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17233321
137Platelet activation_Homo sapiens_hsa046110.16087994
138Inositol phosphate metabolism_Homo sapiens_hsa005620.16048355
139Measles_Homo sapiens_hsa051620.15779900
140Pentose phosphate pathway_Homo sapiens_hsa000300.14632600
141Primary immunodeficiency_Homo sapiens_hsa053400.13539047
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13339398
143Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13091835
144Hematopoietic cell lineage_Homo sapiens_hsa046400.13084734
145Tyrosine metabolism_Homo sapiens_hsa003500.12275873
146Maturity onset diabetes of the young_Homo sapiens_hsa049500.11791175
147Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.11292553
148ECM-receptor interaction_Homo sapiens_hsa045120.11116005
149Arginine biosynthesis_Homo sapiens_hsa002200.10884413
150PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09370573
151Phosphatidylinositol signaling system_Homo sapiens_hsa040700.08769178
152Influenza A_Homo sapiens_hsa051640.08501024
153Notch signaling pathway_Homo sapiens_hsa043300.08430120
154Cyanoamino acid metabolism_Homo sapiens_hsa004600.07935494
155Toxoplasmosis_Homo sapiens_hsa051450.07712190
156AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.07658101
157Regulation of actin cytoskeleton_Homo sapiens_hsa048100.07487372
158Drug metabolism - other enzymes_Homo sapiens_hsa009830.07345252
159Glucagon signaling pathway_Homo sapiens_hsa049220.06233584
160Insulin resistance_Homo sapiens_hsa049310.06007876
161Hedgehog signaling pathway_Homo sapiens_hsa043400.05764976
162Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.05252880

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