ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	innate immune response in mucosa (GO:0002227)	8.59956033
2	mucosal immune response (GO:0002385)	6.94093458
3	fatty acid elongation (GO:0030497)	6.76685169
4	antibacterial humoral response (GO:0019731)	6.70349145
5	organ or tissue specific immune response (GO:0002251)	6.51545930
6	antimicrobial humoral response (GO:0019730)	6.32986194
7	synaptonemal complex assembly (GO:0007130)	5.73997995
8	regulation of memory T cell differentiation (GO:0043380)	5.67341215
9	synaptonemal complex organization (GO:0070193)	5.54616277
10	protein neddylation (GO:0045116)	5.49017042
11	germinal center formation (GO:0002467)	5.46685511
12	meiotic chromosome segregation (GO:0045132)	5.37049140
13	chromosome organization involved in meiosis (GO:0070192)	5.30284023
14	nucleosome assembly (GO:0006334)	4.98097836
15	synapsis (GO:0007129)	4.59903323
16	DNA replication-dependent nucleosome assembly (GO:0006335)	4.35119318
17	DNA replication-dependent nucleosome organization (GO:0034723)	4.35119318
18	regulation of T-helper 2 cell differentiation (GO:0045628)	4.31805370
19	protein-DNA complex assembly (GO:0065004)	4.24842962
20	phagocytosis, recognition (GO:0006910)	4.14998608
21	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	4.14525066
22	negative regulation of T-helper cell differentiation (GO:0045623)	4.14525066
23	nucleosome organization (GO:0034728)	4.11155624
24	positive regulation of protein homodimerization activity (GO:0090073)	4.09532131
25	polyamine biosynthetic process (GO:0006596)	4.00348354
26	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.93347445
27	regulation of megakaryocyte differentiation (GO:0045652)	3.86931919
28	DNA synthesis involved in DNA repair (GO:0000731)	3.86867674
29	regulation of hypersensitivity (GO:0002883)	3.82875635
30	oxygen transport (GO:0015671)	3.81334586
31	DNA unwinding involved in DNA replication (GO:0006268)	3.78641855
32	negative regulation of norepinephrine secretion (GO:0010700)	3.73843149
33	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	3.73502888
34	male meiosis (GO:0007140)	3.73358089
35	neutrophil activation involved in immune response (GO:0002283)	3.61675048
36	protein-DNA complex subunit organization (GO:0071824)	3.61203307
37	meiosis I (GO:0007127)	3.58814145
38	regulation of histone H3-K9 methylation (GO:0051570)	3.57877206
39	rRNA transcription (GO:0009303)	3.53288149
40	platelet formation (GO:0030220)	3.50740121
41	thrombin receptor signaling pathway (GO:0070493)	3.50310873
42	mitochondrial DNA replication (GO:0006264)	3.49993585
43	regulation of Golgi to plasma membrane protein transport (GO:0042996)	3.49548545
44	microtubule depolymerization (GO:0007019)	3.45390149
45	growth hormone receptor signaling pathway (GO:0060396)	3.44811266
46	negative regulation of viral entry into host cell (GO:0046597)	3.40941917
47	male meiosis I (GO:0007141)	3.39332582
48	regulation of integrin activation (GO:0033623)	3.34730176
49	poly(A)+ mRNA export from nucleus (GO:0016973)	3.30087855
50	blood coagulation, intrinsic pathway (GO:0007597)	3.29826435
51	reciprocal meiotic recombination (GO:0007131)	3.28419423
52	reciprocal DNA recombination (GO:0035825)	3.28419423
53	endothelium development (GO:0003158)	3.26126320
54	mRNA cleavage (GO:0006379)	3.22621930
55	low-density lipoprotein particle remodeling (GO:0034374)	3.20346080
56	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	3.19019329
57	cellular biogenic amine biosynthetic process (GO:0042401)	3.15191562
58	gas transport (GO:0015669)	3.14541908
59	megakaryocyte development (GO:0035855)	3.12364985
60	regulation of spindle checkpoint (GO:0090231)	3.11654354
61	defense response to Gram-positive bacterium (GO:0050830)	3.11334282
62	negative regulation of Rho protein signal transduction (GO:0035024)	3.10846342
63	cellular response to growth hormone stimulus (GO:0071378)	3.09037965
64	regulation of germinal center formation (GO:0002634)	3.08229242
65	mitochondrial DNA metabolic process (GO:0032042)	3.06082339
66	purinergic nucleotide receptor signaling pathway (GO:0035590)	3.05820387
67	regulation of hematopoietic progenitor cell differentiation (GO:1901532)	3.05254693
68	meiotic nuclear division (GO:0007126)	3.04967373
69	amine biosynthetic process (GO:0009309)	2.99717406
70	DNA replication initiation (GO:0006270)	2.99237500
71	erythrocyte development (GO:0048821)	2.97522664
72	myeloid cell development (GO:0061515)	2.93236507
73	regulation of viral entry into host cell (GO:0046596)	2.91549704
74	meiotic cell cycle process (GO:1903046)	2.86715427
75	proline biosynthetic process (GO:0006561)	2.85052965
76	regulation of meiosis I (GO:0060631)	2.82263378
77	leukocyte migration involved in inflammatory response (GO:0002523)	2.81390372
78	adenosine receptor signaling pathway (GO:0001973)	2.80444419
79	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	2.78893749
80	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	2.75289200
81	definitive hemopoiesis (GO:0060216)	2.74103416
82	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	2.72565893
83	regulation of platelet activation (GO:0010543)	2.71279767
84	positive regulation of cell cycle checkpoint (GO:1901978)	2.68881695
85	response to growth hormone (GO:0060416)	2.68704766
86	positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)	2.68562804
87	positive regulation of natural killer cell differentiation (GO:0032825)	2.67646273
88	negative regulation of B cell apoptotic process (GO:0002903)	2.67492588
89	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.66904295
90	high-density lipoprotein particle remodeling (GO:0034375)	2.65155924
91	chromatin assembly (GO:0031497)	2.63633385
92	DNA replication checkpoint (GO:0000076)	2.63499495
93	positive regulation of T cell cytokine production (GO:0002726)	2.61899648
94	mitotic sister chromatid segregation (GO:0000070)	2.59303856
95	negative regulation of alpha-beta T cell differentiation (GO:0046639)	2.58937125
96	positive regulation of endothelial cell differentiation (GO:0045603)	2.57232415
97	long-chain fatty-acyl-CoA metabolic process (GO:0035336)	2.56972082
98	platelet aggregation (GO:0070527)	2.56067080
99	regulation of histone H3-K4 methylation (GO:0051569)	2.51498514
100	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.48260759

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	8.40264642
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	5.58664328
3	E2F4_17652178_ChIP-ChIP_JURKAT_Human	4.09047244
4	E2F7_22180533_ChIP-Seq_HELA_Human	3.78846468
5	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.78032728
6	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.61098426
7	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	3.38095744
8	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.11978213
9	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	2.76328829
10	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	2.53543731
11	GATA1_19941826_ChIP-Seq_K562_Human	2.48011474
12	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.26068647
13	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.18777803
14	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.99569890
15	CIITA_25753668_ChIP-Seq_RAJI_Human	1.99364841
16	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.93979749
17	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.89529525
18	GATA2_19941826_ChIP-Seq_K562_Human	1.88487222
19	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.85853009
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.82335515
21	SCL_19346495_ChIP-Seq_HPC-7_Human	1.80019317
22	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.75911846
23	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.71792779
24	ETS1_22383799_ChIP-Seq_G1ME_Mouse	1.70566330
25	ZNF263_19887448_ChIP-Seq_K562_Human	1.68467121
26	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.67186627
27	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.66442187
28	NCOR1_26117541_ChIP-Seq_K562_Human	1.64495088
29	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.62939227
30	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.61392186
31	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.60757054
32	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.60553333
33	VDR_23849224_ChIP-Seq_CD4+_Human	1.57165033
34	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.54819442
35	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.53125874
36	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.51863808
37	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.49699826
38	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.49464691
39	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.49132733
40	DCP1A_22483619_ChIP-Seq_HELA_Human	1.48562706
41	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.47448305
42	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.46220451
43	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.45140333
44	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.43892507
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.43803575
46	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.40208240
47	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.39401151
48	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.37878187
49	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.34941755
50	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.33280813
51	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.31327655
52	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.31214811
53	MAF_26560356_Chip-Seq_TH1_Human	1.29460234
54	SPI1_23127762_ChIP-Seq_K562_Human	1.29207965
55	GATA1_22025678_ChIP-Seq_K562_Human	1.28200603
56	IRF1_19129219_ChIP-ChIP_H3396_Human	1.27254510
57	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.27030545
58	XRN2_22483619_ChIP-Seq_HELA_Human	1.20496030
59	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.18126972
60	KDM5A_27292631_Chip-Seq_BREAST_Human	1.17841745
61	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.17165232
62	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.16840024
63	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.16376195
64	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.15382391
65	P68_20966046_ChIP-Seq_HELA_Human	1.13847179
66	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.13776820
67	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.11772221
68	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.08364185
69	BCOR_27268052_Chip-Seq_Bcells_Human	1.08036065
70	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.07363707
71	TTF2_22483619_ChIP-Seq_HELA_Human	1.06547579
72	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.04269640
73	FOXP3_21729870_ChIP-Seq_TREG_Human	1.03753208
74	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.03233962
75	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.02760845
76	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.02427654
77	E2F1_20622854_ChIP-Seq_HELA_Human	1.01046707
78	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.99992328
79	VDR_21846776_ChIP-Seq_THP-1_Human	0.99800682
80	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.99246728
81	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.98952714
82	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.98550045
83	GABP_19822575_ChIP-Seq_HepG2_Human	0.96826100
84	GATA6_25053715_ChIP-Seq_YYC3_Human	0.96734024
85	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.95203730
86	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.95011509
87	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.94246166
88	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.94198375
89	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.91505093
90	UTX_26944678_Chip-Seq_JUKART_Human	0.90986239
91	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.90215568
92	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.90075759
93	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.88139954
94	CTCF_21964334_Chip-Seq_Bcells_Human	0.86938699
95	MYC_22102868_ChIP-Seq_BL_Human	0.84911106
96	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.84712655
97	ATF3_27146783_Chip-Seq_COLON_Human	0.84360082
98	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.84168373
99	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.83977157
100	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.83258604

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005464_abnormal_platelet_physiology	4.95723244
2	MP0002138_abnormal_hepatobiliary_system	3.97761126
3	MP0004147_increased_porphyrin_level	3.73804736
4	MP0008057_abnormal_DNA_replication	3.49076141
5	MP0008058_abnormal_DNA_repair	2.90369849
6	MP0004381_abnormal_hair_follicle	2.89236854
7	MP0008004_abnormal_stomach_pH	2.82937968
8	MP0003111_abnormal_nucleus_morphology	2.76435351
9	MP0010094_abnormal_chromosome_stability	2.58104215
10	MP0004808_abnormal_hematopoietic_stem	2.55642928
11	MP0005083_abnormal_biliary_tract	2.45055686
12	MP0005360_urolithiasis	2.42100354
13	MP0001835_abnormal_antigen_presentation	2.22970854
14	MP0003693_abnormal_embryo_hatching	2.22135838
15	MP0002132_abnormal_respiratory_system	2.08789705
16	MP0005623_abnormal_meninges_morphology	1.96110881
17	MP0001849_ear_inflammation	1.94808779
18	MP0005410_abnormal_fertilization	1.94568163
19	MP0008932_abnormal_embryonic_tissue	1.94069211
20	MP0005167_abnormal_blood-brain_barrier	1.91084009
21	MP0003718_maternal_effect	1.88588526
22	MP0004957_abnormal_blastocyst_morpholog	1.82967689
23	MP0008995_early_reproductive_senescence	1.81229221
24	MP0008007_abnormal_cellular_replicative	1.73610363
25	MP0001545_abnormal_hematopoietic_system	1.66986592
26	MP0005397_hematopoietic_system_phenotyp	1.66986592
27	MP0004947_skin_inflammation	1.63477326
28	MP0002166_altered_tumor_susceptibility	1.62169567
29	MP0001929_abnormal_gametogenesis	1.55265385
30	MP0001661_extended_life_span	1.54958948
31	MP0005075_abnormal_melanosome_morpholog	1.54687468
32	MP0003879_abnormal_hair_cell	1.54218279
33	MP0001879_abnormal_lymphatic_vessel	1.51890087
34	MP0008875_abnormal_xenobiotic_pharmacok	1.50689109
35	MP0002210_abnormal_sex_determination	1.49422451
36	MP0000685_abnormal_immune_system	1.48912426
37	MP0003724_increased_susceptibility_to	1.45894232
38	MP0001853_heart_inflammation	1.44836195
39	MP0000490_abnormal_crypts_of	1.43235262
40	MP0006035_abnormal_mitochondrial_morpho	1.41855909
41	MP0008775_abnormal_heart_ventricle	1.39764470
42	MP0003698_abnormal_male_reproductive	1.39294714
43	MP0003077_abnormal_cell_cycle	1.38933048
44	MP0003786_premature_aging	1.35420875
45	MP0005646_abnormal_pituitary_gland	1.29726807
46	MP0002398_abnormal_bone_marrow	1.21054710
47	MP0003656_abnormal_erythrocyte_physiolo	1.20480015
48	MP0010368_abnormal_lymphatic_system	1.19883814
49	MP0004130_abnormal_muscle_cell	1.13481163
50	MP0000313_abnormal_cell_death	1.12881527
51	MP0001145_abnormal_male_reproductive	1.12530543
52	MP0006036_abnormal_mitochondrial_physio	1.09179308
53	MP0002722_abnormal_immune_system	1.08302829
54	MP0005076_abnormal_cell_differentiation	1.06095521
55	MP0000653_abnormal_sex_gland	1.05746105
56	MP0002971_abnormal_brown_adipose	1.02069674
57	MP0002006_tumorigenesis	1.01064194
58	MP0000689_abnormal_spleen_morphology	1.01017355
59	MP0005501_abnormal_skin_physiology	1.00886724
60	MP0000609_abnormal_liver_physiology	0.99002584
61	MP0002396_abnormal_hematopoietic_system	0.97877435
62	MP0004510_myositis	0.97592533
63	MP0001697_abnormal_embryo_size	0.97340611
64	MP0006276_abnormal_autonomic_nervous	0.96713495
65	MP0005365_abnormal_bile_salt	0.95262422
66	MP0000703_abnormal_thymus_morphology	0.95216190
67	MP0009333_abnormal_splenocyte_physiolog	0.92190508
68	MP0005647_abnormal_sex_gland	0.91301256
69	MP0002638_abnormal_pupillary_reflex	0.90097825
70	MP0004858_abnormal_nervous_system	0.89557416
71	MP0001542_abnormal_bone_strength	0.89145835
72	MP0005535_abnormal_body_temperature	0.88950286
73	MP0002429_abnormal_blood_cell	0.88614554
74	MP0002089_abnormal_postnatal_growth/wei	0.88432925
75	MP0003699_abnormal_female_reproductive	0.87476666
76	MP0002019_abnormal_tumor_incidence	0.86449434
77	MP0004084_abnormal_cardiac_muscle	0.85887461
78	MP0000358_abnormal_cell_content/	0.84257842
79	MP0002161_abnormal_fertility/fecundity	0.84001153
80	MP0000230_abnormal_systemic_arterial	0.83820917
81	MP0009763_increased_sensitivity_to	0.82940683
82	MP0008872_abnormal_physiological_respon	0.82165153
83	MP0002086_abnormal_extraembryonic_tissu	0.81721869
84	MP0008961_abnormal_basal_metabolism	0.78261657
85	MP0000350_abnormal_cell_proliferation	0.77302997
86	MP0005220_abnormal_exocrine_pancreas	0.77284439
87	MP0000598_abnormal_liver_morphology	0.76063307
88	MP0009697_abnormal_copulation	0.75294292
89	MP0000343_altered_response_to	0.74499076
90	MP0005636_abnormal_mineral_homeostasis	0.73328680
91	MP0006054_spinal_hemorrhage	0.73026171
92	MP0002332_abnormal_exercise_endurance	0.72772561
93	MP0001730_embryonic_growth_arrest	0.71809959
94	MP0010329_abnormal_lipoprotein_level	0.70651747
95	MP0002405_respiratory_system_inflammati	0.68085659
96	MP0001502_abnormal_circadian_rhythm	0.67777419
97	MP0002080_prenatal_lethality	0.66468374
98	MP0004043_abnormal_pH_regulation	0.65387355
99	MP0001915_intracranial_hemorrhage	0.64611602
100	MP0004036_abnormal_muscle_relaxation	0.63776977

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prolonged bleeding time (HP:0003010)	5.99525624
2	Menorrhagia (HP:0000132)	5.33413500
3	Dyschromatopsia (HP:0007641)	5.11027430
4	Abnormality of alanine metabolism (HP:0010916)	4.63152321
5	Hyperalaninemia (HP:0003348)	4.63152321
6	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.63152321
7	Acanthocytosis (HP:0001927)	4.53978812
8	Ileus (HP:0002595)	4.53436386
9	Petechiae (HP:0000967)	4.48793808
10	Increased mean platelet volume (HP:0011877)	4.42961436
11	Large eyes (HP:0001090)	4.42759421
12	Abnormality of the fingertips (HP:0001211)	4.33004902
13	Poikilocytosis (HP:0004447)	4.25405503
14	Epistaxis (HP:0000421)	4.12630831
15	Abnormal platelet function (HP:0011869)	4.08600795
16	Impaired platelet aggregation (HP:0003540)	4.08600795
17	Elevated erythrocyte sedimentation rate (HP:0003565)	4.07141183
18	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.05191334
19	Abnormal platelet volume (HP:0011876)	3.98772434
20	Purpura (HP:0000979)	3.82439806
21	Paralysis (HP:0003470)	3.82007632
22	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.68809933
23	Chronic otitis media (HP:0000389)	3.65073420
24	Chromsome breakage (HP:0040012)	3.58215057
25	3-Methylglutaconic aciduria (HP:0003535)	3.54788929
26	Squamous cell carcinoma (HP:0002860)	3.27986483
27	Reduced subcutaneous adipose tissue (HP:0003758)	3.24220570
28	Clubbing of toes (HP:0100760)	3.16655772
29	Gingival bleeding (HP:0000225)	3.12960396
30	Male infertility (HP:0003251)	3.10637765
31	Spontaneous abortion (HP:0005268)	3.03798701
32	Hyperlipoproteinemia (HP:0010980)	2.87095928
33	Decreased central vision (HP:0007663)	2.79386150
34	Abnormality of the common coagulation pathway (HP:0010990)	2.68899728
35	Polycythemia (HP:0001901)	2.67478919
36	Generalized aminoaciduria (HP:0002909)	2.61061372
37	Myelodysplasia (HP:0002863)	2.60686316
38	Abnormality of pyrimidine metabolism (HP:0004353)	2.54961302
39	Tinnitus (HP:0000360)	2.54267835
40	Prominent nose (HP:0000448)	2.46385657
41	Flat occiput (HP:0005469)	2.42801454
42	Abnormality of iron homeostasis (HP:0011031)	2.39906810
43	Abnormal spermatogenesis (HP:0008669)	2.39657386
44	Abnormality of transition element cation homeostasis (HP:0011030)	2.39546747
45	Reticulocytosis (HP:0001923)	2.34587168
46	Azoospermia (HP:0000027)	2.34024186
47	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.29884557
48	Chronic sinusitis (HP:0011109)	2.29822449
49	Abnormality of the preputium (HP:0100587)	2.29011311
50	Bone marrow hypocellularity (HP:0005528)	2.28888872
51	Duplicated collecting system (HP:0000081)	2.28513676
52	Nausea (HP:0002018)	2.26725394
53	Increased serum ferritin (HP:0003281)	2.25003478
54	Meckel diverticulum (HP:0002245)	2.23633825
55	Nasal polyposis (HP:0100582)	2.20192672
56	Joint hemorrhage (HP:0005261)	2.20170562
57	Basal ganglia calcification (HP:0002135)	2.20032373
58	Abnormality of the ileum (HP:0001549)	2.16847216
59	Abnormality of the renal collecting system (HP:0004742)	2.12373898
60	Ectopic kidney (HP:0000086)	2.10575101
61	Hypertriglyceridemia (HP:0002155)	2.09445209
62	Upper limb muscle weakness (HP:0003484)	2.09365224
63	Ankyloglossia (HP:0010296)	2.09203070
64	Flat cornea (HP:0007720)	2.06225351
65	Premature graying of hair (HP:0002216)	2.03171323
66	Bruising susceptibility (HP:0000978)	2.03139896
67	Renal duplication (HP:0000075)	2.02913212
68	Lymphedema (HP:0001004)	2.00771215
69	Recurrent corneal erosions (HP:0000495)	1.99047220
70	Microretrognathia (HP:0000308)	1.98096607
71	Papillary thyroid carcinoma (HP:0002895)	1.97537048
72	Abnormality of serum amino acid levels (HP:0003112)	1.93576424
73	Abnormality of cochlea (HP:0000375)	1.91662294
74	Abnormality of homocysteine metabolism (HP:0010919)	1.91471793
75	Homocystinuria (HP:0002156)	1.91471793
76	Rough bone trabeculation (HP:0100670)	1.86829811
77	Arthropathy (HP:0003040)	1.85711257
78	Birth length less than 3rd percentile (HP:0003561)	1.82902949
79	Xanthomatosis (HP:0000991)	1.82119462
80	Microcytic anemia (HP:0001935)	1.81267609
81	Ectopia lentis (HP:0001083)	1.79848754
82	Duodenal stenosis (HP:0100867)	1.78392608
83	Small intestinal stenosis (HP:0012848)	1.78392608
84	Prolonged partial thromboplastin time (HP:0003645)	1.77447681
85	Abnormal pupillary function (HP:0007686)	1.71615374
86	Pancytopenia (HP:0001876)	1.68501698
87	Thyroid carcinoma (HP:0002890)	1.67859234
88	Multiple enchondromatosis (HP:0005701)	1.67855119
89	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.67167232
90	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.67167232
91	Abnormal trabecular bone morphology (HP:0100671)	1.64764977
92	Hemorrhage of the eye (HP:0011885)	1.64671495
93	Abnormality of reticulocytes (HP:0004312)	1.64507237
94	Hyperammonemia (HP:0001987)	1.62674555
95	Sparse lateral eyebrow (HP:0005338)	1.61649221
96	Abnormality of the carotid arteries (HP:0005344)	1.59970662
97	Breast hypoplasia (HP:0003187)	1.57123412
98	Dysautonomia (HP:0002459)	1.56756582
99	Abnormality of DNA repair (HP:0003254)	1.56360389
100	Oral leukoplakia (HP:0002745)	1.55796304

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	7.63506988
2	ZAK	7.58394626
3	MST4	3.14507490
4	VRK1	2.84107138
5	STK16	2.59607454
6	EIF2AK1	2.53227546
7	RPS6KA5	2.52024806
8	PDK2	2.03041561
9	BMX	1.88627097
10	SIK2	1.78744784
11	RIPK4	1.70066262
12	ICK	1.69318480
13	CCNB1	1.63583780
14	MAPKAPK3	1.49607760
15	STK4	1.47771144
16	PKN1	1.44236754
17	CDK12	1.40252993
18	ACVR1B	1.35984360
19	MARK3	1.33614763
20	IKBKB	1.32871414
21	WNK4	1.32276570
22	IRAK1	1.31369191
23	PIM1	1.24762190
24	RAF1	1.24300689
25	MAPK11	1.22462953
26	PIM2	1.20984558
27	BMPR2	1.17679168
28	MAP3K5	1.17369458
29	MAP3K2	1.13823075
30	IRAK3	1.10420209
31	KSR2	1.10333748
32	DYRK3	1.07267945
33	BRSK2	1.06049730
34	AKT3	1.04929271
35	PIK3CG	1.00067815
36	AURKA	0.96509553
37	ATR	0.94899765
38	SRPK1	0.94099052
39	TAOK1	0.92341861
40	TEC	0.89321027
41	TAOK2	0.86562976
42	BTK	0.86220602
43	MAP3K8	0.85612906
44	SCYL2	0.85563687
45	KSR1	0.85411357
46	CHEK2	0.84874828
47	PAK1	0.83295037
48	IRAK2	0.83011426
49	EPHA3	0.77100756
50	STK3	0.76993331
51	TESK2	0.72752127
52	MST1R	0.72598535
53	MAP2K3	0.70434277
54	SIK3	0.70364061
55	CHUK	0.70069783
56	PRKAA1	0.69627242
57	TTK	0.68908686
58	PDPK1	0.67734669
59	MAP2K1	0.67189419
60	AURKB	0.64833943
61	JAK2	0.60405555
62	DAPK3	0.59420145
63	SIK1	0.56347134
64	MYLK	0.56265037
65	PDK1	0.55562635
66	MAP3K1	0.52384317
67	BRAF	0.50170250
68	MAP3K11	0.49821088
69	SYK	0.48281411
70	ILK	0.48102364
71	FER	0.47917288
72	ARAF	0.46379972
73	PBK	0.44615465
74	EEF2K	0.43097993
75	CDK8	0.41641788
76	BUB1	0.40966868
77	TRPM7	0.39370608
78	WEE1	0.39234210
79	CDK9	0.39100101
80	BMPR1B	0.37182043
81	CHEK1	0.36290873
82	GRK5	0.32923523
83	PTK2B	0.29024242
84	FRK	0.27798655
85	PLK3	0.27215035
86	ATM	0.25253801
87	RET	0.24856742
88	CDC7	0.24843179
89	ADRBK2	0.24721667
90	MET	0.23227838
91	MAPKAPK5	0.23204670
92	AKT2	0.23202672
93	PKN2	0.21208755
94	PRKCI	0.20036985
95	MAPK3	0.18630195
96	MAP2K2	0.18447716
97	PRKACG	0.18398265
98	NME1	0.17989590
99	PLK4	0.17696371
100	NEK2	0.17548370

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Alcoholism_Homo sapiens_hsa05034	7.52946373
2	Viral carcinogenesis_Homo sapiens_hsa05203	3.99896216
3	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.63805096
4	DNA replication_Homo sapiens_hsa03030	2.20014052
5	Systemic lupus erythematosus_Homo sapiens_hsa05322	10.1991169
6	Homologous recombination_Homo sapiens_hsa03440	1.99595000
7	Nitrogen metabolism_Homo sapiens_hsa00910	1.98615436
8	Mismatch repair_Homo sapiens_hsa03430	1.75057797
9	Fatty acid elongation_Homo sapiens_hsa00062	1.68107219
10	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.63248371
11	Fanconi anemia pathway_Homo sapiens_hsa03460	1.58862135
12	Platelet activation_Homo sapiens_hsa04611	1.42970022
13	Sulfur relay system_Homo sapiens_hsa04122	1.40366819
14	One carbon pool by folate_Homo sapiens_hsa00670	1.32833292
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.32423947
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.27803376
17	Nucleotide excision repair_Homo sapiens_hsa03420	1.11740910
18	Cell cycle_Homo sapiens_hsa04110	1.10401432
19	p53 signaling pathway_Homo sapiens_hsa04115	1.10077215
20	RNA polymerase_Homo sapiens_hsa03020	1.09749271
21	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.98832564
22	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.90937091
23	mRNA surveillance pathway_Homo sapiens_hsa03015	0.85172951
24	RNA transport_Homo sapiens_hsa03013	0.84197016
25	Pyrimidine metabolism_Homo sapiens_hsa00240	0.83816853
26	Olfactory transduction_Homo sapiens_hsa04740	0.79125171
27	Basal transcription factors_Homo sapiens_hsa03022	0.74906935
28	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.74242042
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.72277587
30	Purine metabolism_Homo sapiens_hsa00230	0.71755930
31	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.68630262
32	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.65279661
33	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.61228265
34	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.61108285
35	Serotonergic synapse_Homo sapiens_hsa04726	0.59930229
36	Legionellosis_Homo sapiens_hsa05134	0.54522281
37	ABC transporters_Homo sapiens_hsa02010	0.53745115
38	Oocyte meiosis_Homo sapiens_hsa04114	0.53702000
39	Complement and coagulation cascades_Homo sapiens_hsa04610	0.52770740
40	Non-small cell lung cancer_Homo sapiens_hsa05223	0.51669290
41	FoxO signaling pathway_Homo sapiens_hsa04068	0.50361320
42	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.48876364
43	Circadian rhythm_Homo sapiens_hsa04710	0.47612571
44	Base excision repair_Homo sapiens_hsa03410	0.45706746
45	Sulfur metabolism_Homo sapiens_hsa00920	0.44329428
46	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.43459216
47	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.43170066
48	Herpes simplex infection_Homo sapiens_hsa05168	0.42078055
49	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.41736022
50	Bladder cancer_Homo sapiens_hsa05219	0.41052372
51	Primary immunodeficiency_Homo sapiens_hsa05340	0.39187725
52	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.39156322
53	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.38886538
54	Thyroid cancer_Homo sapiens_hsa05216	0.36802792
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.36672309
56	Small cell lung cancer_Homo sapiens_hsa05222	0.36094714
57	Pancreatic cancer_Homo sapiens_hsa05212	0.35314367
58	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.35264561
59	Spliceosome_Homo sapiens_hsa03040	0.33810577
60	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.32597243
61	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.32478366
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.32459310
63	Choline metabolism in cancer_Homo sapiens_hsa05231	0.30091324
64	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.30074291
65	Type II diabetes mellitus_Homo sapiens_hsa04930	0.29901194
66	mTOR signaling pathway_Homo sapiens_hsa04150	0.28625942
67	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.28177469
68	Arginine and proline metabolism_Homo sapiens_hsa00330	0.27864042
69	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.27457863
70	Proteasome_Homo sapiens_hsa03050	0.26964349
71	Apoptosis_Homo sapiens_hsa04210	0.26900760
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.25109960
73	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.23318453
74	Endometrial cancer_Homo sapiens_hsa05213	0.22845099
75	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.22310950
76	Lysine degradation_Homo sapiens_hsa00310	0.22100988
77	Selenocompound metabolism_Homo sapiens_hsa00450	0.21644086
78	Non-homologous end-joining_Homo sapiens_hsa03450	0.21429797
79	Glutathione metabolism_Homo sapiens_hsa00480	0.20255642
80	Galactose metabolism_Homo sapiens_hsa00052	0.19781909
81	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.19023396
82	Steroid biosynthesis_Homo sapiens_hsa00100	0.19009919
83	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.18362917
84	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.17822365
85	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.17676673
86	Insulin signaling pathway_Homo sapiens_hsa04910	0.16912763
87	Acute myeloid leukemia_Homo sapiens_hsa05221	0.16781392
88	Prolactin signaling pathway_Homo sapiens_hsa04917	0.16779818
89	Taste transduction_Homo sapiens_hsa04742	0.15698210
90	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.15614445
91	Collecting duct acid secretion_Homo sapiens_hsa04966	0.14682924
92	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.13129551
93	Bile secretion_Homo sapiens_hsa04976	0.12934538
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.12717943
95	ECM-receptor interaction_Homo sapiens_hsa04512	0.12544121
96	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.12128224
97	HTLV-I infection_Homo sapiens_hsa05166	0.10764259
98	Insulin resistance_Homo sapiens_hsa04931	0.10661908
99	Graft-versus-host disease_Homo sapiens_hsa05332	0.10484277
100	Renin-angiotensin system_Homo sapiens_hsa04614	0.09559485

HIST1H4PS1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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