HIST2H2AA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antibacterial humoral response (GO:0019731)9.57830532
2organ or tissue specific immune response (GO:0002251)9.21112241
3antimicrobial humoral response (GO:0019730)8.85345629
4DNA replication-dependent nucleosome assembly (GO:0006335)8.27065354
5DNA replication-dependent nucleosome organization (GO:0034723)8.27065354
6chromatin assembly (GO:0031497)7.79839379
7nucleosome assembly (GO:0006334)7.31118785
8protein-DNA complex assembly (GO:0065004)6.19773099
9nucleosome organization (GO:0034728)6.08359348
10protein-DNA complex subunit organization (GO:0071824)5.31294736
11chromatin assembly or disassembly (GO:0006333)5.17777097
12nuclear pore complex assembly (GO:0051292)5.08702995
13nuclear pore organization (GO:0006999)4.74012749
14DNA unwinding involved in DNA replication (GO:0006268)4.67756398
15DNA strand elongation involved in DNA replication (GO:0006271)4.54139378
16defense response to Gram-positive bacterium (GO:0050830)4.38258372
17DNA strand elongation (GO:0022616)4.35327466
18DNA replication initiation (GO:0006270)4.26916587
19pore complex assembly (GO:0046931)3.97944203
20telomere maintenance via semi-conservative replication (GO:0032201)3.97119271
21negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.95755630
22viral mRNA export from host cell nucleus (GO:0046784)3.89288122
23protein localization to chromosome, centromeric region (GO:0071459)3.84475625
24immunoglobulin mediated immune response (GO:0016064)3.75728551
25regulation of histone H3-K9 methylation (GO:0051570)3.74280939
26negative regulation of B cell apoptotic process (GO:0002903)3.63004138
27T-helper 1 type immune response (GO:0042088)3.50288880
28mitotic chromosome condensation (GO:0007076)3.49517026
29mitotic sister chromatid segregation (GO:0000070)3.44279085
30telomere maintenance via recombination (GO:0000722)3.39712814
31proline biosynthetic process (GO:0006561)3.38764835
32B cell mediated immunity (GO:0019724)3.36591907
33positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.27478466
34mitotic nuclear envelope disassembly (GO:0007077)3.25545138
35B cell receptor signaling pathway (GO:0050853)3.20206884
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17597369
37ribosomal small subunit biogenesis (GO:0042274)3.16877304
38sister chromatid segregation (GO:0000819)3.16864480
39mitotic recombination (GO:0006312)3.11091467
40regulation of translational fidelity (GO:0006450)3.05103489
41mature B cell differentiation involved in immune response (GO:0002313)3.02865831
42nuclear envelope disassembly (GO:0051081)3.01792133
43membrane disassembly (GO:0030397)3.01792133
44regulation of mammary gland epithelial cell proliferation (GO:0033599)2.97357472
45regulation of megakaryocyte differentiation (GO:0045652)2.97142109
46regulation of B cell apoptotic process (GO:0002902)2.94976979
47CENP-A containing nucleosome assembly (GO:0034080)2.93874419
48regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.93408979
49DNA duplex unwinding (GO:0032508)2.91201400
50regulation of sister chromatid cohesion (GO:0007063)2.84280597
51chromatin remodeling at centromere (GO:0031055)2.83120988
52B cell proliferation (GO:0042100)2.81733505
53peptidyl-arginine omega-N-methylation (GO:0035247)2.76830797
54DNA geometric change (GO:0032392)2.76132465
55nucleobase-containing small molecule interconversion (GO:0015949)2.70797704
56rRNA transcription (GO:0009303)2.70067866
57protein localization to kinetochore (GO:0034501)2.68569789
58negative regulation of B cell proliferation (GO:0030889)2.64448574
59nucleotide-excision repair, DNA gap filling (GO:0006297)2.64240834
60humoral immune response (GO:0006959)2.64002407
61DNA synthesis involved in DNA repair (GO:0000731)2.62999176
62positive regulation of macrophage cytokine production (GO:0060907)2.62327085
63formation of translation preinitiation complex (GO:0001731)2.60302115
64regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.59282694
65folic acid metabolic process (GO:0046655)2.58006602
66cellular protein complex localization (GO:0034629)2.57411771
67positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.56949733
68antigen processing and presentation of endogenous antigen (GO:0019883)2.54416847
69spliceosomal tri-snRNP complex assembly (GO:0000244)2.52279804
70positive regulation of chromosome segregation (GO:0051984)2.52219969
71positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.51319018
72negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.47905024
73B cell homeostasis (GO:0001782)2.46929085
74positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.46340023
75mature B cell differentiation (GO:0002335)2.46062516
76telomere maintenance (GO:0000723)2.45942182
77telomere organization (GO:0032200)2.45762357
78T cell migration (GO:0072678)2.45287882
79protein complex localization (GO:0031503)2.45091477
80chaperone mediated protein folding requiring cofactor (GO:0051085)2.42892165
81regulation of chromosome segregation (GO:0051983)2.42774387
82urea cycle (GO:0000050)2.42740407
83deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.41365730
84mitochondrial DNA metabolic process (GO:0032042)2.40700202
85antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.39383698
86maturation of SSU-rRNA (GO:0030490)2.38893089
87mitochondrial fusion (GO:0008053)2.38046417
88deoxyribonucleotide biosynthetic process (GO:0009263)2.37692386
89cellular response to UV (GO:0034644)2.35979173
90nuclear envelope organization (GO:0006998)2.34935772
91telomere maintenance via telomere lengthening (GO:0010833)2.34495048
92translesion synthesis (GO:0019985)2.33360320
93detection of bacterium (GO:0016045)2.33180218
94ribonucleoprotein complex biogenesis (GO:0022613)2.33103009
95DNA conformation change (GO:0071103)2.32251246
96double-strand break repair via nonhomologous end joining (GO:0006303)2.31498852
97non-recombinational repair (GO:0000726)2.31498852
98regulation of protein heterodimerization activity (GO:0043497)2.29921546
99innate immune response in mucosa (GO:0002227)12.1250733
100mucosal immune response (GO:0002385)10.0459698

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.43533411
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.75875895
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65570140
4TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.93435496
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.78031940
6EGR1_23403033_ChIP-Seq_LIVER_Mouse2.61360317
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.46018055
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.44540239
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26282889
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.17501937
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.12914225
12MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.01834749
13HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse2.01192341
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.01078343
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse15.3554907
16SOX2_16153702_ChIP-ChIP_HESCs_Human1.98657333
17MYC_18555785_ChIP-Seq_MESCs_Mouse1.96038272
18CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.95432184
19VDR_21846776_ChIP-Seq_THP-1_Human1.84041685
20NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78263579
21MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72468765
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69308130
23RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67621660
24ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67397001
25STAT4_19710469_ChIP-ChIP_TH1__Mouse1.62877821
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.62687971
27MYC_22102868_ChIP-Seq_BL_Human1.62546679
28ERG_20887958_ChIP-Seq_HPC-7_Mouse1.61120547
29HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49246823
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42720111
31IRF1_19129219_ChIP-ChIP_H3396_Human1.41077171
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40765973
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.37996605
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37701947
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37062651
36DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31693361
37KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.28442851
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.23765969
39KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22265505
40* MAF_26560356_Chip-Seq_TH1_Human1.21783107
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21686999
42TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20460322
43XRN2_22483619_ChIP-Seq_HELA_Human1.19364950
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18487349
45* VDR_23849224_ChIP-Seq_CD4+_Human1.18080463
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.17168911
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15795098
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15748867
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14505473
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13809339
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.13406924
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11922128
53SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10941807
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10221815
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09634254
56DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08008327
57KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07619358
58GATA1_22025678_ChIP-Seq_K562_Human1.07052250
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.06695910
60ZNF263_19887448_ChIP-Seq_K562_Human1.05623915
61CIITA_25753668_ChIP-Seq_RAJI_Human1.05592549
62AR_21909140_ChIP-Seq_LNCAP_Human1.01554752
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00709670
64DCP1A_22483619_ChIP-Seq_HELA_Human0.99241357
65ETS1_22383799_ChIP-Seq_G1ME_Mouse0.97506282
66SOX2_18692474_ChIP-Seq_MESCs_Mouse0.97466393
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96304311
68SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95675637
69ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95147529
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93725539
71NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93561745
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92558447
73NANOG_16153702_ChIP-ChIP_HESCs_Human0.92102129
74MYC_18940864_ChIP-ChIP_HL60_Human0.90760692
75ETS1_20019798_ChIP-Seq_JURKAT_Human0.90759615
76PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90441154
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89987478
78NOTCH1_21737748_ChIP-Seq_TLL_Human0.88749284
79FOXP3_21729870_ChIP-Seq_TREG_Human0.86255876
80ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85649010
81VDR_24763502_ChIP-Seq_THP-1_Human0.84505510
82ELK1_19687146_ChIP-ChIP_HELA_Human0.80650052
83MYB_26560356_Chip-Seq_TH1_Human0.80637576
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.79614300
85* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.78451899
86NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.78426934
87UTX_26944678_Chip-Seq_JUKART_Human0.77777608
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77610094
89PKCTHETA_26484144_Chip-Seq_BREAST_Human0.76814824
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.76613644
91PADI4_21655091_ChIP-ChIP_MCF-7_Human0.76328006
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75368183
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.75187331
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.74641223
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73312865
96SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.72888560
97MAF_26560356_Chip-Seq_TH2_Human0.71323857
98TTF2_22483619_ChIP-Seq_HELA_Human0.70679163
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.70093371
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.68213939

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.92438362
2MP0003111_abnormal_nucleus_morphology3.65230554
3MP0005645_abnormal_hypothalamus_physiol3.62525840
4MP0003077_abnormal_cell_cycle3.52856086
5MP0000685_abnormal_immune_system3.45291765
6MP0008057_abnormal_DNA_replication3.22297235
7MP0003693_abnormal_embryo_hatching2.91308044
8MP0004957_abnormal_blastocyst_morpholog2.67941069
9MP0001835_abnormal_antigen_presentation2.63978032
10MP0010352_gastrointestinal_tract_polyps2.58379170
11MP0005671_abnormal_response_to2.51302233
12MP0002009_preneoplasia2.50649476
13MP0003763_abnormal_thymus_physiology2.50146903
14MP0002877_abnormal_melanocyte_morpholog2.30541744
15MP0005623_abnormal_meninges_morphology2.30427017
16MP0001800_abnormal_humoral_immune2.19165594
17MP0002166_altered_tumor_susceptibility2.19070757
18MP0010234_abnormal_vibrissa_follicle2.05561535
19MP0008007_abnormal_cellular_replicative2.05191114
20MP0010307_abnormal_tumor_latency2.03963932
21MP0000350_abnormal_cell_proliferation1.87431180
22MP0008058_abnormal_DNA_repair1.87174054
23MP0005387_immune_system_phenotype1.87143667
24MP0001790_abnormal_immune_system1.87143667
25MP0002398_abnormal_bone_marrow1.83748567
26MP0000490_abnormal_crypts_of1.81262597
27MP0005000_abnormal_immune_tolerance1.78848139
28MP0003303_peritoneal_inflammation1.78119897
29MP0002396_abnormal_hematopoietic_system1.76404080
30MP0008932_abnormal_embryonic_tissue1.75357637
31MP0004808_abnormal_hematopoietic_stem1.70853015
32MP0001727_abnormal_embryo_implantation1.68754936
33MP0003786_premature_aging1.64007264
34MP0002006_tumorigenesis1.62931211
35MP0002452_abnormal_antigen_presenting1.58012645
36MP0001661_extended_life_span1.56095035
37MP0002019_abnormal_tumor_incidence1.53648246
38MP0002723_abnormal_immune_serum1.52281518
39MP0002722_abnormal_immune_system1.51911820
40MP0002420_abnormal_adaptive_immunity1.50444241
41MP0001819_abnormal_immune_cell1.46613876
42MP0000689_abnormal_spleen_morphology1.41442323
43MP0002429_abnormal_blood_cell1.41187886
44MP0000716_abnormal_immune_system1.41143452
45MP0000313_abnormal_cell_death1.39357623
46MP0000703_abnormal_thymus_morphology1.38515679
47MP0003183_abnormal_peptide_metabolism1.36732210
48MP0009333_abnormal_splenocyte_physiolog1.33720563
49MP0004185_abnormal_adipocyte_glucose1.29399306
50MP0000537_abnormal_urethra_morphology1.28317616
51MP0005451_abnormal_body_composition1.27654065
52MP0005076_abnormal_cell_differentiation1.24851280
53MP0005025_abnormal_response_to1.21856272
54MP0000358_abnormal_cell_content/1.14425978
55MP0001730_embryonic_growth_arrest1.06178672
56MP0006035_abnormal_mitochondrial_morpho1.06000496
57MP0008260_abnormal_autophagy1.04385946
58MP0005464_abnormal_platelet_physiology1.04378947
59MP0002080_prenatal_lethality1.03401176
60MP0000465_gastrointestinal_hemorrhage1.01615244
61MP0004947_skin_inflammation0.98113845
62MP0001348_abnormal_lacrimal_gland0.98052679
63MP0003436_decreased_susceptibility_to0.97155620
64MP0005310_abnormal_salivary_gland0.94205364
65MP0003300_gastrointestinal_ulcer0.94127132
66MP0001873_stomach_inflammation0.93995816
67MP0000015_abnormal_ear_pigmentation0.93967978
68MP0002138_abnormal_hepatobiliary_system0.93649246
69MP0001845_abnormal_inflammatory_respons0.93074707
70MP0003453_abnormal_keratinocyte_physiol0.92937279
71MP0002086_abnormal_extraembryonic_tissu0.92518175
72MP0002163_abnormal_gland_morphology0.92303360
73MP0010155_abnormal_intestine_physiology0.92016141
74MP0005380_embryogenesis_phenotype0.87630912
75MP0001672_abnormal_embryogenesis/_devel0.87630912
76MP0009785_altered_susceptibility_to0.85823935
77MP0001346_abnormal_lacrimal_gland0.85434401
78MP0004233_abnormal_muscle_weight0.84968278
79MP0005621_abnormal_cell_physiology0.84384824
80MP0005384_cellular_phenotype0.84262588
81MP0002419_abnormal_innate_immunity0.82967103
82MP0001849_ear_inflammation0.81583299
83MP0002928_abnormal_bile_duct0.81480205
84MP0003984_embryonic_growth_retardation0.80504314
85MP0005083_abnormal_biliary_tract0.79744607
86MP0005220_abnormal_exocrine_pancreas0.76478908
87MP0002088_abnormal_embryonic_growth/wei0.75806054
88MP0002160_abnormal_reproductive_system0.75122998
89MP0002148_abnormal_hypersensitivity_rea0.74732165
90MP0001697_abnormal_embryo_size0.73075667
91MP0009046_muscle_twitch0.69365202
92MP0000858_altered_metastatic_potential0.68406080
93MP0009278_abnormal_bone_marrow0.68244788
94MP0001919_abnormal_reproductive_system0.65912416
95MP0005501_abnormal_skin_physiology0.65642969
96MP0000733_abnormal_muscle_development0.64633828
97MP0003806_abnormal_nucleotide_metabolis0.64297671
98MP0002092_abnormal_eye_morphology0.61179137
99MP0005647_abnormal_sex_gland0.59679784
100MP0003221_abnormal_cardiomyocyte_apopto0.59140867

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)6.23781625
2IgA deficiency (HP:0002720)6.15397970
3Gastrointestinal stroma tumor (HP:0100723)5.77455322
4Cellulitis (HP:0100658)4.22740613
5Recurrent sinusitis (HP:0011108)4.12895732
6Squamous cell carcinoma (HP:0002860)4.11288433
7Colitis (HP:0002583)4.00942393
8Agammaglobulinemia (HP:0004432)3.86134608
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.73590409
10Recurrent bronchitis (HP:0002837)3.71521362
11Lymphopenia (HP:0001888)3.63091928
12Abnormality of cells of the lymphoid lineage (HP:0012140)3.51173128
13Dry hair (HP:0011359)3.44936582
14Chromsome breakage (HP:0040012)3.16388613
15Eczematoid dermatitis (HP:0000976)3.07791600
16Onycholysis (HP:0001806)3.07770031
17Microvesicular hepatic steatosis (HP:0001414)3.06781676
18Meningitis (HP:0001287)2.99641935
19Emphysema (HP:0002097)2.95914069
20Recurrent bacterial skin infections (HP:0005406)2.94599559
21Erythema (HP:0010783)2.80660683
22Aplasia/Hypoplasia of the sacrum (HP:0008517)2.75841336
23Abnormality of T cell physiology (HP:0011840)2.63670569
24Osteomyelitis (HP:0002754)2.62909505
25Urticaria (HP:0001025)2.61970009
26Ridged nail (HP:0001807)2.57953864
27Mediastinal lymphadenopathy (HP:0100721)2.57248219
28Reticulocytopenia (HP:0001896)2.57224276
29Inflammation of the large intestine (HP:0002037)2.57194722
30Recurrent pneumonia (HP:0006532)2.55025831
31Vasculitis (HP:0002633)2.52609357
32Chronic diarrhea (HP:0002028)2.52216780
33Leukopenia (HP:0001882)2.51314864
34Gastrointestinal inflammation (HP:0004386)2.49829088
35Recurrent abscess formation (HP:0002722)2.44168028
36Abnormal gallbladder physiology (HP:0012438)2.43700837
37Cholecystitis (HP:0001082)2.43700837
38Entropion (HP:0000621)2.42440721
39Recurrent viral infections (HP:0004429)2.40825293
40Basal cell carcinoma (HP:0002671)2.39881093
41Abnormality of cells of the erythroid lineage (HP:0012130)2.39457626
42Progressive muscle weakness (HP:0003323)2.37051602
43Lymphoma (HP:0002665)2.35077316
44Hyperacusis (HP:0010780)2.32780965
45Recurrent lower respiratory tract infections (HP:0002783)2.30062118
46Interstitial pulmonary disease (HP:0006530)2.29226458
47Ragged-red muscle fibers (HP:0003200)2.26799420
48Abnormality of the preputium (HP:0100587)2.26417278
49IgG deficiency (HP:0004315)2.24162168
50Hepatitis (HP:0012115)2.21920979
51Viral hepatitis (HP:0006562)2.21152585
52Petechiae (HP:0000967)2.14525699
53Sparse scalp hair (HP:0002209)2.10243860
54Abnormal number of erythroid precursors (HP:0012131)2.08381313
55Micronodular cirrhosis (HP:0001413)2.06071176
5611 pairs of ribs (HP:0000878)2.04956477
57Broad distal phalanx of finger (HP:0009836)2.04953522
58Insomnia (HP:0100785)2.03607685
59Birth length less than 3rd percentile (HP:0003561)2.02455218
60Abnormality of chromosome stability (HP:0003220)2.02360747
61Prostate neoplasm (HP:0100787)1.99953333
62Skin rash (HP:0000988)1.97767683
63Spastic diplegia (HP:0001264)1.97470672
64Restrictive lung disease (HP:0002091)1.95558196
65Abnormality of macrophages (HP:0004311)1.92254513
66Septate vagina (HP:0001153)1.92179657
67Chronic obstructive pulmonary disease (HP:0006510)1.89772085
68Obstructive lung disease (HP:0006536)1.89772085
69Abnormality of the prostate (HP:0008775)1.89207783
70Orthostatic hypotension (HP:0001278)1.87213943
71Poikiloderma (HP:0001029)1.87178891
72Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86958976
73Abnormality of DNA repair (HP:0003254)1.86763166
74Cutaneous melanoma (HP:0012056)1.86646164
75Aplasia/Hypoplasia of the uvula (HP:0010293)1.86549585
76Hypergonadotropic hypogonadism (HP:0000815)1.85510562
77B lymphocytopenia (HP:0010976)1.82853099
78Large eyes (HP:0001090)1.82562244
79Subacute progressive viral hepatitis (HP:0006572)1.81145441
80Increased intramyocellular lipid droplets (HP:0012240)1.80401211
81Progressive external ophthalmoplegia (HP:0000590)1.79991439
82Acute lymphatic leukemia (HP:0006721)1.79881256
83Premature loss of primary teeth (HP:0006323)1.79409178
84Increased muscle lipid content (HP:0009058)1.78859129
85Abnormality of pyrimidine metabolism (HP:0004353)1.75490059
86Abnormality of the fingertips (HP:0001211)1.75389604
87Bronchitis (HP:0012387)1.73205935
88Breast hypoplasia (HP:0003187)1.71909929
89Abnormality of the ileum (HP:0001549)1.71501436
90Deep palmar crease (HP:0006191)1.69873355
91Cutaneous photosensitivity (HP:0000992)1.69649829
92Autoimmune hemolytic anemia (HP:0001890)1.69079397
93Conical tooth (HP:0000698)1.68852757
94Abnormality of incisor morphology (HP:0011063)1.66998444
95Ureteral duplication (HP:0000073)1.65840313
96Sepsis (HP:0100806)1.64489249
97Clubbing of toes (HP:0100760)1.64186780
98Abnormality of the carotid arteries (HP:0005344)1.64102598
99Long palpebral fissure (HP:0000637)1.63183371
100Recurrent otitis media (HP:0000403)1.61648919

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK8.98000923
2TLK18.72796636
3VRK15.61814936
4RPS6KA53.40685805
5DAPK32.94410023
6AURKA2.30722191
7SMG12.06832919
8BUB11.99037726
9CDC71.70999981
10NME21.59492052
11STK41.58472061
12EEF2K1.56669048
13CHEK21.41923309
14IRAK41.33350667
15PIM11.32825363
16TRIB31.27508953
17AURKB1.26542053
18PBK1.24161912
19SCYL21.19098930
20PKN11.17288048
21NEK11.00531134
22IRAK30.94038723
23BCKDK0.89566396
24RPS6KB20.85791597
25ICK0.84682011
26PIM20.83202769
27BRAF0.81151807
28MAP3K80.79833324
29BTK0.72099706
30ARAF0.71100678
31AKT20.67861718
32TAF10.66836694
33CCNB10.65361411
34PRPF4B0.63576217
35BLK0.63499268
36TTK0.63479342
37CDK120.62615399
38TBK10.58662303
39ATR0.58434549
40SRPK10.58429741
41KDR0.56077657
42TESK20.53188063
43SYK0.53056607
44MAPK110.52961104
45NEK90.52949538
46MAP2K30.52212797
47STK160.50603322
48MAP4K10.49856011
49IKBKB0.49254388
50TTN0.48929584
51MAP3K140.48561230
52CDK70.47553878
53BRSK20.43853211
54PLK10.39427709
55CHEK10.37561796
56PAK10.36492357
57RIPK40.35936862
58LYN0.35158295
59CDK80.35072973
60CDK40.34875079
61PRKCQ0.34578837
62JAK20.33927096
63PRKAA10.33241935
64CDK60.32771701
65MELK0.32679590
66EIF2AK30.31649074
67MAPKAPK50.30156313
68MAP3K100.29611971
69CSNK1G30.28604216
70WEE10.28283046
71RAF10.27724313
72MAP3K130.26111962
73IKBKE0.24935918
74CDK20.23767230
75CSNK1A1L0.23460310
76STK100.23441418
77PRKCD0.21413896
78BMPR20.19836567
79MAP3K110.19449542
80MAP2K20.18939446
81BRSK10.17842279
82CSNK1G10.17508091
83TSSK60.17435664
84CSF1R0.16390895
85MAP3K90.16389281
86CDK90.16057794
87VRK20.15769982
88ATM0.15129264
89ILK0.14838898
90PKN20.14820145
91ALK0.13714501
92FGFR40.12863374
93CDK10.12463781
94CAMK40.12384664
95RPS6KA10.12310283
96RPS6KC10.12168598
97RPS6KL10.12168598
98NEK20.12015542
99PDK20.11906235
100ABL20.09820718

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050347.55742403
2Viral carcinogenesis_Homo sapiens_hsa052033.44469176
3DNA replication_Homo sapiens_hsa030302.45665731
4* Systemic lupus erythematosus_Homo sapiens_hsa0532210.9997649
5Transcriptional misregulation in cancer_Homo sapiens_hsa052021.92409797
6Intestinal immune network for IgA production_Homo sapiens_hsa046721.87322139
7Allograft rejection_Homo sapiens_hsa053301.65965511
8Asthma_Homo sapiens_hsa053101.60133486
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54822235
10Autoimmune thyroid disease_Homo sapiens_hsa053201.52337313
11Mismatch repair_Homo sapiens_hsa034301.49137434
12Primary immunodeficiency_Homo sapiens_hsa053401.45302507
13Graft-versus-host disease_Homo sapiens_hsa053321.33198947
14Viral myocarditis_Homo sapiens_hsa054161.17081616
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16672417
16Sulfur relay system_Homo sapiens_hsa041221.15444280
17Type I diabetes mellitus_Homo sapiens_hsa049401.13566358
18B cell receptor signaling pathway_Homo sapiens_hsa046621.11416258
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05930496
20Cell cycle_Homo sapiens_hsa041101.03260601
21Ribosome_Homo sapiens_hsa030101.02917878
22Pentose phosphate pathway_Homo sapiens_hsa000301.01820466
23Base excision repair_Homo sapiens_hsa034101.01776028
24Nucleotide excision repair_Homo sapiens_hsa034200.91382462
25Leishmaniasis_Homo sapiens_hsa051400.90616117
26Non-homologous end-joining_Homo sapiens_hsa034500.87566769
27Biosynthesis of amino acids_Homo sapiens_hsa012300.86260483
28Antigen processing and presentation_Homo sapiens_hsa046120.82249591
29p53 signaling pathway_Homo sapiens_hsa041150.80777685
30Homologous recombination_Homo sapiens_hsa034400.74761716
31Herpes simplex infection_Homo sapiens_hsa051680.74334571
32Epstein-Barr virus infection_Homo sapiens_hsa051690.72276998
33Fanconi anemia pathway_Homo sapiens_hsa034600.69716665
34Pyrimidine metabolism_Homo sapiens_hsa002400.68666492
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67083113
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66947210
37Vitamin B6 metabolism_Homo sapiens_hsa007500.63789112
38HTLV-I infection_Homo sapiens_hsa051660.59043184
39Influenza A_Homo sapiens_hsa051640.57801637
40Spliceosome_Homo sapiens_hsa030400.57656893
41Fructose and mannose metabolism_Homo sapiens_hsa000510.57564076
42Carbon metabolism_Homo sapiens_hsa012000.56301402
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52165979
44RNA transport_Homo sapiens_hsa030130.50851945
45Central carbon metabolism in cancer_Homo sapiens_hsa052300.49634637
46Galactose metabolism_Homo sapiens_hsa000520.47032935
47Apoptosis_Homo sapiens_hsa042100.45381451
48NF-kappa B signaling pathway_Homo sapiens_hsa040640.40206802
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40002815
50Non-small cell lung cancer_Homo sapiens_hsa052230.37395303
51Toxoplasmosis_Homo sapiens_hsa051450.37131009
52One carbon pool by folate_Homo sapiens_hsa006700.35923327
53Measles_Homo sapiens_hsa051620.35624113
54Staphylococcus aureus infection_Homo sapiens_hsa051500.34822749
55Bladder cancer_Homo sapiens_hsa052190.34762721
56Hepatitis B_Homo sapiens_hsa051610.32980204
57Pancreatic cancer_Homo sapiens_hsa052120.32722629
58Chronic myeloid leukemia_Homo sapiens_hsa052200.32571568
59Proteasome_Homo sapiens_hsa030500.30813397
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29921924
61Purine metabolism_Homo sapiens_hsa002300.28966712
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.28487600
63N-Glycan biosynthesis_Homo sapiens_hsa005100.28182927
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27986200
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27642856
66Acute myeloid leukemia_Homo sapiens_hsa052210.23628009
67Hematopoietic cell lineage_Homo sapiens_hsa046400.23501678
68Phenylalanine metabolism_Homo sapiens_hsa003600.23438951
69Tuberculosis_Homo sapiens_hsa051520.23435355
70Rheumatoid arthritis_Homo sapiens_hsa053230.21428416
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20318714
72Small cell lung cancer_Homo sapiens_hsa052220.20234062
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19852175
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19580480
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18779075
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18363584
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.18199592
78Colorectal cancer_Homo sapiens_hsa052100.17406765
79RNA polymerase_Homo sapiens_hsa030200.17003198
80HIF-1 signaling pathway_Homo sapiens_hsa040660.16865667
81Shigellosis_Homo sapiens_hsa051310.16326921
82Phagosome_Homo sapiens_hsa041450.15437984
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14612132
84MicroRNAs in cancer_Homo sapiens_hsa052060.12899002
85Osteoclast differentiation_Homo sapiens_hsa043800.11417455
86Selenocompound metabolism_Homo sapiens_hsa004500.09761643
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.09710216
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.09301678
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.08936289
90Glioma_Homo sapiens_hsa052140.08851816
91Pyruvate metabolism_Homo sapiens_hsa006200.08428063
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.07928176
93Thyroid cancer_Homo sapiens_hsa052160.07910069
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.07899420
95Parkinsons disease_Homo sapiens_hsa050120.07686590
96Huntingtons disease_Homo sapiens_hsa050160.07633836
97RNA degradation_Homo sapiens_hsa030180.07281968
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.04462267
99Inositol phosphate metabolism_Homo sapiens_hsa005620.04280996
100VEGF signaling pathway_Homo sapiens_hsa043700.04127083

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