HIST2H2AA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1innate immune response in mucosa (GO:0002227)9.49642868
2mucosal immune response (GO:0002385)8.01755634
3antibacterial humoral response (GO:0019731)7.42162971
4organ or tissue specific immune response (GO:0002251)7.35823268
5antimicrobial humoral response (GO:0019730)6.82035597
6DNA replication-dependent nucleosome assembly (GO:0006335)6.70461953
7DNA replication-dependent nucleosome organization (GO:0034723)6.70461953
8nucleosome assembly (GO:0006334)6.37430313
9nuclear pore complex assembly (GO:0051292)5.99124246
10regulation of histone H3-K9 methylation (GO:0051570)5.36550690
11nucleosome organization (GO:0034728)5.34675037
12protein-DNA complex assembly (GO:0065004)5.33620386
13nuclear pore organization (GO:0006999)5.30358541
14chromatin assembly (GO:0031497)4.86526531
15pore complex assembly (GO:0046931)4.84337111
16protein-DNA complex subunit organization (GO:0071824)4.61408388
17definitive hemopoiesis (GO:0060216)4.36277550
18mature B cell differentiation involved in immune response (GO:0002313)4.14156905
19dosage compensation (GO:0007549)3.96645871
20defense response to Gram-positive bacterium (GO:0050830)3.85824813
21negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.73496261
22chromatin assembly or disassembly (GO:0006333)3.65765113
23viral mRNA export from host cell nucleus (GO:0046784)3.40141088
24mitochondrial DNA metabolic process (GO:0032042)3.36940450
25regulation of megakaryocyte differentiation (GO:0045652)3.35428407
26DNA replication initiation (GO:0006270)3.30741991
27aggressive behavior (GO:0002118)3.29969095
28mature B cell differentiation (GO:0002335)3.29326735
29positive regulation of fatty acid biosynthetic process (GO:0045723)3.28586549
30DNA unwinding involved in DNA replication (GO:0006268)3.26451869
31meiotic chromosome segregation (GO:0045132)3.22608329
32negative regulation of B cell apoptotic process (GO:0002903)3.22103052
33DNA duplex unwinding (GO:0032508)3.20503809
34peptidyl-lysine dimethylation (GO:0018027)3.20124609
35positive thymic T cell selection (GO:0045059)3.16807604
36replicative senescence (GO:0090399)3.15315283
37DNA synthesis involved in DNA repair (GO:0000731)3.14108929
38DNA geometric change (GO:0032392)3.11984714
39DNA strand elongation involved in DNA replication (GO:0006271)3.10436287
40DNA strand elongation (GO:0022616)3.09109472
41pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.08137794
42negative regulation of thymocyte apoptotic process (GO:0070244)3.02532001
43regulation of mammary gland epithelial cell proliferation (GO:0033599)3.02526506
44positive regulation of B cell differentiation (GO:0045579)2.95843422
45positive regulation of systemic arterial blood pressure (GO:0003084)2.92102368
46B cell receptor signaling pathway (GO:0050853)2.90286438
47protein kinase C signaling (GO:0070528)2.86216460
48regulation of DNA damage checkpoint (GO:2000001)2.83280641
49positive T cell selection (GO:0043368)2.82386818
50regulation of centrosome cycle (GO:0046605)2.81808572
51mitotic chromosome condensation (GO:0007076)2.80062299
52immunoglobulin mediated immune response (GO:0016064)2.78282881
53regulation of translational fidelity (GO:0006450)2.77874663
54telomere maintenance via semi-conservative replication (GO:0032201)2.74612712
55negative regulation of DNA repair (GO:0045738)2.74580254
56regulation of centrosome duplication (GO:0010824)2.72516975
57regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.71058887
58maturation of SSU-rRNA (GO:0030490)2.68164497
59cellular response to exogenous dsRNA (GO:0071360)2.67967421
60positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.67223447
61thrombin receptor signaling pathway (GO:0070493)2.63484285
62megakaryocyte development (GO:0035855)2.63125741
63telomere organization (GO:0032200)2.62941831
64regulation of integrin activation (GO:0033623)2.62247361
65V(D)J recombination (GO:0033151)2.60880319
66positive regulation of granulocyte differentiation (GO:0030854)2.60007301
67grooming behavior (GO:0007625)2.59850961
68embryonic process involved in female pregnancy (GO:0060136)2.59320920
69telomere maintenance (GO:0000723)2.58114527
70positive regulation of keratinocyte differentiation (GO:0045618)2.57868021
71maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.57166478
72pyrimidine nucleotide catabolic process (GO:0006244)2.57090774
73regulation of B cell apoptotic process (GO:0002902)2.53588301
74replication fork processing (GO:0031297)2.53429219
75rRNA transcription (GO:0009303)2.53419937
76DNA topological change (GO:0006265)2.52956362
77regulation of sister chromatid cohesion (GO:0007063)2.50947582
78telomere maintenance via recombination (GO:0000722)2.48143102
79peptidyl-arginine omega-N-methylation (GO:0035247)2.47930978
80DNA conformation change (GO:0071103)2.47703973
81mitochondrial DNA replication (GO:0006264)2.47554396
82nucleotide salvage (GO:0043173)2.47115764
83regulation of RIG-I signaling pathway (GO:0039535)2.45833901
84regulation of female receptivity (GO:0045924)2.44389063
85telomere maintenance via telomere lengthening (GO:0010833)2.42127198
86B cell mediated immunity (GO:0019724)2.37829003
87maturation of 5.8S rRNA (GO:0000460)2.36008076
88negative regulation of lymphocyte apoptotic process (GO:0070229)2.35546556
89mitotic recombination (GO:0006312)2.35119045
90translesion synthesis (GO:0019985)2.33898772
91regulation of centriole replication (GO:0046599)2.33437002
92DNA replication checkpoint (GO:0000076)2.30393820
93regulation of double-strand break repair via homologous recombination (GO:0010569)2.30255446
94hyperosmotic salinity response (GO:0042538)2.30201265
95positive regulation of interferon-alpha production (GO:0032727)2.30141790
96regulation of interferon-beta production (GO:0032648)2.28779699
97snRNA transcription (GO:0009301)2.28401380
98regulation of cell cycle checkpoint (GO:1901976)2.27323885
99snRNA metabolic process (GO:0016073)2.27094445
100DNA biosynthetic process (GO:0071897)2.23671924

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.22025736
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.13334334
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.93655544
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.26638999
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.69570147
6TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.68676077
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.65313107
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.16074515
9VDR_21846776_ChIP-Seq_THP-1_Human2.15186291
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.12319423
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse15.0786065
12HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.99668918
13GATA1_22025678_ChIP-Seq_K562_Human1.96097902
14MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76398584
15E2F1_21310950_ChIP-Seq_MCF-7_Human1.75207470
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71756437
17MYC_22102868_ChIP-Seq_BL_Human1.69688668
18SCL_19346495_ChIP-Seq_HPC-7_Human1.65925557
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.61638748
20CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.61230108
21ERG_20887958_ChIP-Seq_HPC-7_Mouse1.60778285
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.53003105
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50162833
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.48358315
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45910280
26SOX2_16153702_ChIP-ChIP_HESCs_Human1.44856376
27HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43621859
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43355668
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.41971283
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37000263
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36109968
32TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35457337
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31783097
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31730795
35VDR_23849224_ChIP-Seq_CD4+_Human1.29992605
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23869616
37CIITA_25753668_ChIP-Seq_RAJI_Human1.23563182
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23204940
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18267370
40VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16356797
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15932967
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15653430
43ETS1_22383799_ChIP-Seq_G1ME_Mouse1.14904168
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14817658
45MAF_26560356_Chip-Seq_TH1_Human1.14544513
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12665692
47VDR_24763502_ChIP-Seq_THP-1_Human1.12229981
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11968497
49XRN2_22483619_ChIP-Seq_HELA_Human1.10206523
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08026997
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06562953
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05907446
53PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05759913
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05458380
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05158954
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05003162
57IRF1_19129219_ChIP-ChIP_H3396_Human1.04093583
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04035983
59FOXP3_21729870_ChIP-Seq_TREG_Human1.02068477
60KDM5A_27292631_Chip-Seq_BREAST_Human1.00680811
61RUNX1_22412390_ChIP-Seq_EML_Mouse0.99967558
62THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99108981
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98919268
64UTX_26944678_Chip-Seq_JUKART_Human0.97151614
65MYB_26560356_Chip-Seq_TH1_Human0.95605687
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.94056087
67DCP1A_22483619_ChIP-Seq_HELA_Human0.90659021
68NOTCH1_21737748_ChIP-Seq_TLL_Human0.89229215
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.88215524
70* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87914414
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87796684
72TCF7_22412390_ChIP-Seq_EML_Mouse0.87484147
73* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84449596
74ETS1_20019798_ChIP-Seq_JURKAT_Human0.83521690
75SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82510937
76MAF_26560356_Chip-Seq_TH2_Human0.80822916
77MYB_26560356_Chip-Seq_TH2_Human0.80443218
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.80054040
79GATA2_22383799_ChIP-Seq_G1ME_Mouse0.79766014
80NCOR1_26117541_ChIP-Seq_K562_Human0.79086618
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.78884629
82STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77570967
83ELF1_20517297_ChIP-Seq_JURKAT_Human0.77434463
84ELK1_19687146_ChIP-ChIP_HELA_Human0.77278743
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.76828435
86SPI1_23547873_ChIP-Seq_NB4_Human0.76542436
87PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75609847
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75580548
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.75238029
90BCOR_27268052_Chip-Seq_Bcells_Human0.74576417
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.73902665
92KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.73886470
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.73759306
94GATA1_19941826_ChIP-Seq_K562_Human0.71487626
95ZNF263_19887448_ChIP-Seq_K562_Human0.70759994
96HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.70691438
97GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70370025
98MYB_21317192_ChIP-Seq_ERMYB_Mouse0.69861584
99ZFX_18555785_ChIP-Seq_MESCs_Mouse0.69267440
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.69115928

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.45512880
2MP0003111_abnormal_nucleus_morphology3.24647156
3MP0008057_abnormal_DNA_replication3.15659221
4MP0002396_abnormal_hematopoietic_system3.07684610
5MP0004808_abnormal_hematopoietic_stem3.02723169
6MP0002009_preneoplasia2.91046490
7MP0003693_abnormal_embryo_hatching2.90418012
8MP0009278_abnormal_bone_marrow2.71080954
9MP0005083_abnormal_biliary_tract2.69360087
10MP0003077_abnormal_cell_cycle2.56322865
11MP0009697_abnormal_copulation2.47999723
12MP0010307_abnormal_tumor_latency2.34467725
13MP0003763_abnormal_thymus_physiology2.26994240
14MP0005397_hematopoietic_system_phenotyp2.22758487
15MP0001545_abnormal_hematopoietic_system2.22758487
16MP0001835_abnormal_antigen_presentation2.13827937
17MP0005464_abnormal_platelet_physiology2.10462985
18MP0003786_premature_aging2.01611561
19MP0001661_extended_life_span2.00032294
20MP0008058_abnormal_DNA_repair1.99885373
21MP0004185_abnormal_adipocyte_glucose1.91285911
22MP0005076_abnormal_cell_differentiation1.90957180
23MP0008007_abnormal_cellular_replicative1.90243684
24MP0002166_altered_tumor_susceptibility1.89326546
25MP0000465_gastrointestinal_hemorrhage1.85120446
26MP0004957_abnormal_blastocyst_morpholog1.80797870
27MP0002398_abnormal_bone_marrow1.64777983
28MP0010352_gastrointestinal_tract_polyps1.61794636
29MP0000383_abnormal_hair_follicle1.61249468
30MP0001986_abnormal_taste_sensitivity1.60343659
31MP0002019_abnormal_tumor_incidence1.60191914
32MP0005220_abnormal_exocrine_pancreas1.50115548
33MP0002722_abnormal_immune_system1.43737757
34MP0010678_abnormal_skin_adnexa1.41701603
35MP0002006_tumorigenesis1.39928619
36MP0003656_abnormal_erythrocyte_physiolo1.39924832
37MP0000537_abnormal_urethra_morphology1.39205698
38MP0003303_peritoneal_inflammation1.36322863
39MP0000703_abnormal_thymus_morphology1.31475561
40MP0000490_abnormal_crypts_of1.30658260
41MP0000689_abnormal_spleen_morphology1.29672298
42MP0000350_abnormal_cell_proliferation1.27949348
43MP0003806_abnormal_nucleotide_metabolis1.26319654
44MP0000013_abnormal_adipose_tissue1.23365457
45MP0000015_abnormal_ear_pigmentation1.23290405
46MP0000313_abnormal_cell_death1.18421100
47MP0002429_abnormal_blood_cell1.18270297
48MP0004947_skin_inflammation1.15176546
49MP0008932_abnormal_embryonic_tissue1.14019105
50MP0009764_decreased_sensitivity_to1.13627302
51MP0004381_abnormal_hair_follicle1.13022515
52MP0005000_abnormal_immune_tolerance1.12052440
53MP0001800_abnormal_humoral_immune1.10859382
54MP0002877_abnormal_melanocyte_morpholog1.10528305
55MP0000716_abnormal_immune_system1.09863281
56MP0010234_abnormal_vibrissa_follicle1.07523991
57MP0002420_abnormal_adaptive_immunity1.05385992
58MP0002452_abnormal_antigen_presenting1.04600777
59MP0002086_abnormal_extraembryonic_tissu1.03121421
60MP0001819_abnormal_immune_cell1.02957219
61MP0000003_abnormal_adipose_tissue1.02576855
62MP0003191_abnormal_cellular_cholesterol1.01331761
63MP0002723_abnormal_immune_serum0.97959559
64MP0000358_abnormal_cell_content/0.97262815
65MP0003724_increased_susceptibility_to0.96683567
66MP0003718_maternal_effect0.93380713
67MP0010155_abnormal_intestine_physiology0.91085540
68MP0008995_early_reproductive_senescence0.90747720
69MP0005645_abnormal_hypothalamus_physiol0.90536349
70MP0002405_respiratory_system_inflammati0.90522241
71MP0002160_abnormal_reproductive_system0.86435914
72MP0009931_abnormal_skin_appearance0.86333512
73MP0005171_absent_coat_pigmentation0.85244984
74MP0003252_abnormal_bile_duct0.83629071
75MP0000685_abnormal_immune_system0.83304589
76MP0005621_abnormal_cell_physiology0.82652344
77MP0002332_abnormal_exercise_endurance0.81644411
78MP0004233_abnormal_muscle_weight0.80995353
79MP0002080_prenatal_lethality0.80668650
80MP0001873_stomach_inflammation0.79494240
81MP0003436_decreased_susceptibility_to0.78997492
82MP0002098_abnormal_vibrissa_morphology0.77718558
83MP0001216_abnormal_epidermal_layer0.77091389
84MP0005501_abnormal_skin_physiology0.76967081
85MP0001697_abnormal_embryo_size0.75883221
86MP0005384_cellular_phenotype0.75086907
87MP0002060_abnormal_skin_morphology0.74874162
88MP0001243_abnormal_dermal_layer0.74785273
89MP0006035_abnormal_mitochondrial_morpho0.74761298
90MP0005451_abnormal_body_composition0.74638190
91MP0001191_abnormal_skin_condition0.72549533
92MP0005025_abnormal_response_to0.72220796
93MP0003984_embryonic_growth_retardation0.68439090
94MP0005380_embryogenesis_phenotype0.67459233
95MP0001672_abnormal_embryogenesis/_devel0.67459233
96MP0002419_abnormal_innate_immunity0.67419438
97MP0000569_abnormal_digit_pigmentation0.67215233
98MP0005310_abnormal_salivary_gland0.67203071
99MP0004134_abnormal_chest_morphology0.67115207
100MP0002148_abnormal_hypersensitivity_rea0.66469755

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.10339211
2Colitis (HP:0002583)4.91013263
3Chromsome breakage (HP:0040012)4.47638737
4Abnormality of B cell number (HP:0010975)3.39654750
5Microvesicular hepatic steatosis (HP:0001414)3.32333047
6B lymphocytopenia (HP:0010976)3.25537914
7Panhypogammaglobulinemia (HP:0003139)3.11105480
8Autoimmune hemolytic anemia (HP:0001890)3.08657361
9Cellulitis (HP:0100658)3.05840897
10Thrombocytosis (HP:0001894)3.03506214
11Oral leukoplakia (HP:0002745)2.96601758
12Myelodysplasia (HP:0002863)2.95954487
13Recurrent viral infections (HP:0004429)2.95210270
14Neoplasm of the heart (HP:0100544)2.93731180
15IgM deficiency (HP:0002850)2.90419391
16Squamous cell carcinoma (HP:0002860)2.86141526
17Inflammation of the large intestine (HP:0002037)2.81027959
18Abnormality of the preputium (HP:0100587)2.78760939
19Viral hepatitis (HP:0006562)2.74012704
20Thyroiditis (HP:0100646)2.72382266
21Medulloblastoma (HP:0002885)2.72098691
22Short thumb (HP:0009778)2.71764747
23Short 4th metacarpal (HP:0010044)2.71218698
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71218698
25Abnormality of chromosome stability (HP:0003220)2.70418376
26Gastrointestinal inflammation (HP:0004386)2.69616117
27IgA deficiency (HP:0002720)2.69099933
28Abnormal number of erythroid precursors (HP:0012131)2.65133727
29Abnormality of cells of the erythroid lineage (HP:0012130)2.59606582
30Abnormality of pyrimidine metabolism (HP:0004353)2.55983533
31Abnormality of the carotid arteries (HP:0005344)2.55006885
32Progressive external ophthalmoplegia (HP:0000590)2.52067213
33Acute lymphatic leukemia (HP:0006721)2.49740599
34Abnormality of the parietal bone (HP:0002696)2.48523606
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.47466586
36Prolonged bleeding time (HP:0003010)2.47198625
37Cerebellar dysplasia (HP:0007033)2.44851796
38Abnormality of the nasal septum (HP:0000419)2.39804904
39Prostate neoplasm (HP:0100787)2.37536676
40Abnormality of the heme biosynthetic pathway (HP:0010472)2.37473983
41Agammaglobulinemia (HP:0004432)2.37217658
42Progressive muscle weakness (HP:0003323)2.37194727
43Clubbing of toes (HP:0100760)2.35707067
44Interstitial pulmonary disease (HP:0006530)2.32522297
45Poikilocytosis (HP:0004447)2.32283875
46Dyschromatopsia (HP:0007641)2.31613388
47Increased serum ferritin (HP:0003281)2.27621275
48Abnormality of the fingertips (HP:0001211)2.27247673
49Abnormality of DNA repair (HP:0003254)2.26341302
50Prominent nose (HP:0000448)2.25804451
51Cutaneous melanoma (HP:0012056)2.24886546
52Bone marrow hypocellularity (HP:0005528)2.21438975
53Abnormality of the prostate (HP:0008775)2.17346367
54Petechiae (HP:0000967)2.17150937
55Epistaxis (HP:0000421)2.16095823
56Short phalanx of the thumb (HP:0009660)2.14671750
57Abnormality of transition element cation homeostasis (HP:0011030)2.12786267
58Rough bone trabeculation (HP:0100670)2.11923214
59Spontaneous abortion (HP:0005268)2.11621595
60Broad face (HP:0000283)2.10720335
61Hypergonadotropic hypogonadism (HP:0000815)2.09308097
62Hypoplasia of the pons (HP:0012110)2.09230512
63Abnormality of the 4th metacarpal (HP:0010012)2.06456614
64Abnormality of iron homeostasis (HP:0011031)2.06283596
65Basal cell carcinoma (HP:0002671)2.06272263
66Premature graying of hair (HP:0002216)2.05682333
67Abnormality of the pons (HP:0007361)2.04335598
68Reticulocytopenia (HP:0001896)2.03946635
69Deep philtrum (HP:0002002)2.03539309
70Duplicated collecting system (HP:0000081)2.03262156
71Asymmetry of the thorax (HP:0001555)2.01138225
72Abnormality of the ileum (HP:0001549)1.97307818
73Absent thumb (HP:0009777)1.96993017
7411 pairs of ribs (HP:0000878)1.96588036
75Tinnitus (HP:0000360)1.96093332
76Sandal gap (HP:0001852)1.94351014
77Micronodular cirrhosis (HP:0001413)1.93571491
78Meckel diverticulum (HP:0002245)1.92213590
79Ureteral duplication (HP:0000073)1.91891786
80Abnormality of the distal phalanx of the thumb (HP:0009617)1.88225784
81Deformed sella turcica (HP:0002681)1.86928816
82Entropion (HP:0000621)1.86095779
83Increased mean platelet volume (HP:0011877)1.82523788
84Abnormality of the proximal phalanges of the hand (HP:0009834)1.81938257
85Acanthocytosis (HP:0001927)1.81061340
86Recurrent fungal infections (HP:0002841)1.80627047
87Granulocytopenia (HP:0001913)1.78478956
88Lymphoma (HP:0002665)1.78021607
89Subacute progressive viral hepatitis (HP:0006572)1.77955001
90Meningioma (HP:0002858)1.77861454
91Hepatitis (HP:0012115)1.76720756
92Abnormal trabecular bone morphology (HP:0100671)1.76464755
93Abnormality of the renal collecting system (HP:0004742)1.76255430
94Orthostatic hypotension (HP:0001278)1.76145032
95Syringomyelia (HP:0003396)1.75557395
96Spinal cord lesions (HP:0100561)1.75557395
97Abnormal platelet volume (HP:0011876)1.74835683
98Pancytopenia (HP:0001876)1.74827809
99Chronic mucocutaneous candidiasis (HP:0002728)1.74451892
100Recurrent cutaneous fungal infections (HP:0011370)1.74451892

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK18.16045918
2ZAK8.09276460
3SCYL23.50714866
4VRK13.20045084
5RPS6KA53.18403957
6STK42.56833878
7TRIB31.88318361
8DAPK31.73027610
9MAP2K31.69577384
10EEF2K1.58950813
11AURKA1.50849865
12PIM11.46237896
13BLK1.41472652
14PIM21.34957157
15RPS6KB21.25388954
16MAP3K101.22200845
17CDC71.20425470
18CDK81.19261528
19AURKB1.16356792
20NME21.15266678
21CHEK21.14662938
22IRAK31.13156130
23BTK1.12372351
24SMG11.11182341
25MAP3K81.08344599
26MAPK111.06708505
27TAOK31.04892003
28PBK0.97731217
29PKN10.96608463
30SRPK10.95167008
31ICK0.90590565
32PKN20.83383077
33ATR0.82804685
34MST1R0.80792449
35TEC0.79279342
36PIK3CG0.76791677
37TBK10.75910076
38BRSK20.75109348
39PRKAA10.70305435
40GRK60.70104460
41BUB10.69442461
42MAP2K20.65431817
43CCNB10.65056967
44MAP2K70.64068556
45IKBKB0.63593505
46MAP4K10.63172928
47SYK0.62569745
48CDK120.61303217
49KDR0.57516646
50BMPR20.56678725
51CDK40.55374189
52STK160.55150114
53RPS6KL10.51085906
54RPS6KC10.51085906
55MAP2K40.50714213
56TTN0.50464062
57FLT30.50130840
58RAF10.49954736
59EIF2AK30.47918378
60CDK60.46329187
61IRAK20.46151711
62PRPF4B0.45342925
63MST40.44749239
64RPS6KA60.43643479
65CDK70.42931846
66MAP3K30.41967572
67MAP3K10.41574515
68CSF1R0.40857141
69MAP3K110.40156135
70MTOR0.39650587
71BCKDK0.36447707
72ATM0.35730504
73HCK0.35658621
74AKT20.34679259
75PLK10.34502606
76TRPM70.33831981
77TESK20.33793738
78IKBKE0.33758248
79MAPKAPK30.33344667
80MAP3K40.32209490
81LYN0.32064202
82CHEK10.31930482
83JAK20.30135042
84TTK0.29224461
85ZAP700.28710748
86FES0.28141422
87ITK0.27365495
88MET0.25576353
89RPS6KB10.25471861
90BRAF0.25369105
91MAP3K140.25244225
92PRKCQ0.24674714
93RPS6KA40.24243848
94CDK20.24182667
95EIF2AK10.23227180
96RPS6KA10.23094481
97PRKCI0.22560425
98IRAK40.22114127
99NEK60.22082194
100ABL20.22015068

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050347.25900747
2Viral carcinogenesis_Homo sapiens_hsa052033.46759643
3DNA replication_Homo sapiens_hsa030302.35858414
4* Systemic lupus erythematosus_Homo sapiens_hsa0532210.5185106
5Transcriptional misregulation in cancer_Homo sapiens_hsa052021.99577074
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60927496
7Fanconi anemia pathway_Homo sapiens_hsa034601.41595769
8Mismatch repair_Homo sapiens_hsa034301.33063452
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28116480
10Homologous recombination_Homo sapiens_hsa034401.26037671
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25481870
12Base excision repair_Homo sapiens_hsa034101.23022987
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.20670603
14Cell cycle_Homo sapiens_hsa041101.16466279
15Non-small cell lung cancer_Homo sapiens_hsa052231.08483479
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06253412
17Primary immunodeficiency_Homo sapiens_hsa053401.05945260
18Nucleotide excision repair_Homo sapiens_hsa034201.02276455
19B cell receptor signaling pathway_Homo sapiens_hsa046620.98874437
20Non-homologous end-joining_Homo sapiens_hsa034500.92355822
21Platelet activation_Homo sapiens_hsa046110.89017043
22Asthma_Homo sapiens_hsa053100.88706984
23Pyrimidine metabolism_Homo sapiens_hsa002400.87615253
24Sulfur relay system_Homo sapiens_hsa041220.87389920
25Chronic myeloid leukemia_Homo sapiens_hsa052200.85333516
26Herpes simplex infection_Homo sapiens_hsa051680.83651036
27Acute myeloid leukemia_Homo sapiens_hsa052210.82924040
28Pancreatic cancer_Homo sapiens_hsa052120.79915052
29One carbon pool by folate_Homo sapiens_hsa006700.78797767
30Bladder cancer_Homo sapiens_hsa052190.77678618
31Small cell lung cancer_Homo sapiens_hsa052220.77027976
32Other glycan degradation_Homo sapiens_hsa005110.76430802
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74704306
34Leishmaniasis_Homo sapiens_hsa051400.72451596
35p53 signaling pathway_Homo sapiens_hsa041150.70642635
36RNA transport_Homo sapiens_hsa030130.69851957
37Allograft rejection_Homo sapiens_hsa053300.67961577
38Inositol phosphate metabolism_Homo sapiens_hsa005620.66341766
39Ribosome_Homo sapiens_hsa030100.65310497
40Intestinal immune network for IgA production_Homo sapiens_hsa046720.63159233
41Selenocompound metabolism_Homo sapiens_hsa004500.62668540
42mTOR signaling pathway_Homo sapiens_hsa041500.61535698
43HTLV-I infection_Homo sapiens_hsa051660.60051883
44Influenza A_Homo sapiens_hsa051640.56980473
45Glioma_Homo sapiens_hsa052140.56927727
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56912318
47Hematopoietic cell lineage_Homo sapiens_hsa046400.55887338
48Measles_Homo sapiens_hsa051620.53563404
49Autoimmune thyroid disease_Homo sapiens_hsa053200.53535875
50Apoptosis_Homo sapiens_hsa042100.53241745
51Hepatitis B_Homo sapiens_hsa051610.53151245
52Graft-versus-host disease_Homo sapiens_hsa053320.52613150
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51283926
54Pentose phosphate pathway_Homo sapiens_hsa000300.50676806
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.50630375
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50505663
57Toxoplasmosis_Homo sapiens_hsa051450.48230364
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48015801
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47644338
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47532702
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45662216
62Sulfur metabolism_Homo sapiens_hsa009200.45309362
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44768156
64Purine metabolism_Homo sapiens_hsa002300.44078802
65Thyroid cancer_Homo sapiens_hsa052160.43056904
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39724241
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.39115667
68Melanoma_Homo sapiens_hsa052180.38363851
69Type I diabetes mellitus_Homo sapiens_hsa049400.36508868
70Epstein-Barr virus infection_Homo sapiens_hsa051690.35724974
71N-Glycan biosynthesis_Homo sapiens_hsa005100.34704026
72Antigen processing and presentation_Homo sapiens_hsa046120.33975961
73Colorectal cancer_Homo sapiens_hsa052100.33325457
74MicroRNAs in cancer_Homo sapiens_hsa052060.33108059
75Osteoclast differentiation_Homo sapiens_hsa043800.32922756
76TNF signaling pathway_Homo sapiens_hsa046680.32636538
77Endometrial cancer_Homo sapiens_hsa052130.31019240
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30701557
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30464417
80RNA polymerase_Homo sapiens_hsa030200.29862665
81Tuberculosis_Homo sapiens_hsa051520.27031246
82Hepatitis C_Homo sapiens_hsa051600.26812607
83Fructose and mannose metabolism_Homo sapiens_hsa000510.26496202
84ErbB signaling pathway_Homo sapiens_hsa040120.26302534
85Prolactin signaling pathway_Homo sapiens_hsa049170.26080409
86Prostate cancer_Homo sapiens_hsa052150.24884329
87VEGF signaling pathway_Homo sapiens_hsa043700.24473538
88Staphylococcus aureus infection_Homo sapiens_hsa051500.23972298
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23836339
90Spliceosome_Homo sapiens_hsa030400.23481275
91Legionellosis_Homo sapiens_hsa051340.23079929
92T cell receptor signaling pathway_Homo sapiens_hsa046600.22767981
93FoxO signaling pathway_Homo sapiens_hsa040680.22518563
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.20192590
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.19613192
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.19298597
97Lysine degradation_Homo sapiens_hsa003100.18127276
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16988506
99Biosynthesis of amino acids_Homo sapiens_hsa012300.16231996
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.16025882

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