HIST2H2AC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)8.54112143
2protoporphyrinogen IX biosynthetic process (GO:0006782)7.68460188
3DNA replication-dependent nucleosome organization (GO:0034723)7.57697949
4DNA replication-dependent nucleosome assembly (GO:0006335)7.57697949
5nucleosome assembly (GO:0006334)7.36702174
6antibacterial humoral response (GO:0019731)6.99269805
7innate immune response in mucosa (GO:0002227)6.74740531
8chromatin assembly (GO:0031497)6.66629315
9antimicrobial humoral response (GO:0019730)6.52405631
10nucleosome organization (GO:0034728)6.30122147
11protein-DNA complex assembly (GO:0065004)6.20894028
12porphyrin-containing compound biosynthetic process (GO:0006779)5.81757176
13erythrocyte maturation (GO:0043249)5.70056820
14regulation of histone H3-K9 methylation (GO:0051570)5.67734187
15mitotic chromosome condensation (GO:0007076)5.67484442
16sister chromatid segregation (GO:0000819)5.54319916
17protein-DNA complex subunit organization (GO:0071824)5.49463255
18protein localization to kinetochore (GO:0034501)5.48267895
19chromatin assembly or disassembly (GO:0006333)5.31629352
20mitotic sister chromatid segregation (GO:0000070)5.29990282
21mucosal immune response (GO:0002385)5.26327839
22DNA unwinding involved in DNA replication (GO:0006268)5.25263277
23heme biosynthetic process (GO:0006783)5.22035945
24tetrapyrrole biosynthetic process (GO:0033014)5.09815278
25protein localization to chromosome, centromeric region (GO:0071459)5.04415051
26organ or tissue specific immune response (GO:0002251)4.97645050
27regulation of DNA endoreduplication (GO:0032875)4.85712644
28kinetochore organization (GO:0051383)4.61407319
29nuclear pore organization (GO:0006999)4.60325503
30nuclear pore complex assembly (GO:0051292)4.57506430
31meiotic chromosome segregation (GO:0045132)4.55072771
32hemoglobin metabolic process (GO:0020027)4.44716152
33regulation of response to osmotic stress (GO:0047484)4.44059171
34regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.42705441
35positive regulation of mitotic sister chromatid separation (GO:1901970)4.39140442
36positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.39140442
37positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.39140442
38porphyrin-containing compound metabolic process (GO:0006778)4.37167720
39erythrocyte development (GO:0048821)4.33312350
40DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.24106800
41microtubule depolymerization (GO:0007019)4.23048642
42CENP-A containing nucleosome assembly (GO:0034080)4.20031972
43regulation of centriole replication (GO:0046599)4.17277253
44chromatin remodeling at centromere (GO:0031055)4.12992732
45attachment of spindle microtubules to kinetochore (GO:0008608)4.11541746
46DNA replication initiation (GO:0006270)4.06028160
47positive regulation of chromosome segregation (GO:0051984)4.03817503
48mature B cell differentiation involved in immune response (GO:0002313)4.02745448
49DNA strand elongation involved in DNA replication (GO:0006271)3.94356577
50peptidyl-lysine dimethylation (GO:0018027)3.91737535
51folic acid-containing compound biosynthetic process (GO:0009396)3.91343144
52protein K6-linked ubiquitination (GO:0085020)3.89759234
53heme metabolic process (GO:0042168)3.88256088
54regulation of centrosome cycle (GO:0046605)3.86839528
55negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.85709730
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.81149948
57telomere maintenance via semi-conservative replication (GO:0032201)3.79520706
58DNA strand elongation (GO:0022616)3.78624946
59defense response to Gram-positive bacterium (GO:0050830)3.78494858
60DNA replication-independent nucleosome organization (GO:0034724)3.77959071
61DNA replication-independent nucleosome assembly (GO:0006336)3.77959071
62ribosomal small subunit biogenesis (GO:0042274)3.76666435
63chromosome condensation (GO:0030261)3.75060246
64DNA damage response, signal transduction resulting in transcription (GO:0042772)3.74973165
65mitotic recombination (GO:0006312)3.74610504
66response to methylmercury (GO:0051597)3.71320109
67pore complex assembly (GO:0046931)3.62455217
68mitotic nuclear envelope disassembly (GO:0007077)3.62350021
69maturation of SSU-rRNA (GO:0030490)3.61138514
70regulation of centrosome duplication (GO:0010824)3.58653162
71regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.58123191
72mitotic metaphase plate congression (GO:0007080)3.57810923
73DNA replication checkpoint (GO:0000076)3.53348847
74DNA geometric change (GO:0032392)3.51054475
75DNA duplex unwinding (GO:0032508)3.49316907
76V(D)J recombination (GO:0033151)3.48908729
77telomere maintenance via recombination (GO:0000722)3.48362778
78embryonic process involved in female pregnancy (GO:0060136)3.48295732
79metaphase plate congression (GO:0051310)3.44898162
80chromosome segregation (GO:0007059)3.44672315
81regulation of sister chromatid cohesion (GO:0007063)3.43339074
82establishment of chromosome localization (GO:0051303)3.41337423
83non-recombinational repair (GO:0000726)3.41049315
84double-strand break repair via nonhomologous end joining (GO:0006303)3.41049315
85regulation of spindle organization (GO:0090224)3.40957817
86membrane disassembly (GO:0030397)3.40956091
87nuclear envelope disassembly (GO:0051081)3.40956091
88negative regulation of DNA repair (GO:0045738)3.40004410
89mitotic sister chromatid cohesion (GO:0007064)3.39719485
90mature B cell differentiation (GO:0002335)3.37276978
91protein localization to chromosome (GO:0034502)3.37097989
92histone exchange (GO:0043486)3.34228004
93kinetochore assembly (GO:0051382)3.31494660
94translesion synthesis (GO:0019985)3.31373871
95DNA topological change (GO:0006265)3.27741370
96regulation of translational fidelity (GO:0006450)3.23614790
97DNA synthesis involved in DNA repair (GO:0000731)3.22141887
98DNA packaging (GO:0006323)3.18890992
99dosage compensation (GO:0007549)3.15276647
100ribosomal small subunit assembly (GO:0000028)3.13133580
101negative regulation of histone methylation (GO:0031061)3.12424545
102regulation of mitotic spindle organization (GO:0060236)3.12268460
103DNA conformation change (GO:0071103)3.11326343
104response to insecticide (GO:0017085)3.11202551
105erythrocyte differentiation (GO:0030218)3.10746412
106postreplication repair (GO:0006301)3.09470305
107response to lead ion (GO:0010288)3.08006328
108positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.06465185
109regulation of chromosome segregation (GO:0051983)3.05267529
110mitotic G2/M transition checkpoint (GO:0044818)3.04280274
111nucleotide-excision repair, DNA gap filling (GO:0006297)3.03810842
112regulation of mitotic metaphase/anaphase transition (GO:0030071)3.03064620
113centrosome duplication (GO:0051298)3.02789443
114histone phosphorylation (GO:0016572)3.02316921
115telomere organization (GO:0032200)3.00481613
116pigment biosynthetic process (GO:0046148)2.99305066
117regulation of mammary gland epithelial cell proliferation (GO:0033599)2.96800097
118telomere maintenance (GO:0000723)2.96358078
119regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94479435
120maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93143025
121urea cycle (GO:0000050)2.92746201
122viral mRNA export from host cell nucleus (GO:0046784)2.92323326
123regulation of megakaryocyte differentiation (GO:0045652)2.85057808
124nucleobase-containing small molecule interconversion (GO:0015949)2.83331945
125mitochondrial DNA metabolic process (GO:0032042)2.81598569
126histone-serine phosphorylation (GO:0035404)2.80870538
127negative regulation of chromosome segregation (GO:0051985)2.77251538
128positive regulation of cell cycle checkpoint (GO:1901978)2.75278164
129regulation of spindle checkpoint (GO:0090231)2.70143293
130viral transcription (GO:0019083)2.69992389
131telomere maintenance via telomere lengthening (GO:0010833)2.69972374
132regulation of double-strand break repair (GO:2000779)2.69314509
133regulation of mitotic sister chromatid separation (GO:0010965)2.67912316
134regulation of mitotic sister chromatid segregation (GO:0033047)2.67912316
135regulation of sister chromatid segregation (GO:0033045)2.67912316
136replication fork processing (GO:0031297)2.67310259
137somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.66532443
138somatic cell DNA recombination (GO:0016444)2.66532443
139DNA ligation (GO:0006266)2.66009709

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.25073666
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.67149400
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.50088608
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.88856291
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05429824
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.03939782
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.64710618
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.52244063
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.48632934
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.30473482
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28044102
12* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.26577923
13TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.18961829
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse13.4263222
15NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94626683
16* SOX2_16153702_ChIP-ChIP_HESCs_Human1.91260439
17CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.86282537
18GATA1_22025678_ChIP-Seq_K562_Human1.85606001
19MYC_18555785_ChIP-Seq_MESCs_Mouse1.79709169
20AR_21909140_ChIP-Seq_LNCAP_Human1.72596529
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70742719
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.66586725
23* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65594462
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.65217741
25ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55044751
26* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.54167286
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53771324
28HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51933799
29* VDR_23849224_ChIP-Seq_CD4+_Human1.49637003
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.49078822
31IRF1_19129219_ChIP-ChIP_H3396_Human1.48971562
32HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.46885007
33* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44948475
34SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.42925310
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42254239
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37284226
37* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27434710
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26442652
39GATA1_19941826_ChIP-Seq_K562_Human1.26208062
40ELK1_19687146_ChIP-ChIP_HELA_Human1.24454542
41KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23497925
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23320483
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23053819
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18957241
45* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17979733
46KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17579483
47MYC_22102868_ChIP-Seq_BL_Human1.15578668
48VDR_21846776_ChIP-Seq_THP-1_Human1.12038664
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11545049
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10628360
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10331312
52KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09631064
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08473361
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08405281
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08353142
56* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07351670
57SCL_19346495_ChIP-Seq_HPC-7_Human1.06314236
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06049466
59* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99612364
60STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99372419
61NANOG_16153702_ChIP-ChIP_HESCs_Human0.96714702
62GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96185316
63MYC_18940864_ChIP-ChIP_HL60_Human0.96152541
64FOXP3_21729870_ChIP-Seq_TREG_Human0.95555399
65XRN2_22483619_ChIP-Seq_HELA_Human0.95526546
66CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95248392
67* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95223513
68MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.94981342
69PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94586324
70ETS1_22383799_ChIP-Seq_G1ME_Mouse0.93493583
71KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92451929
72* GATA1_19941827_ChIP-Seq_MEL_Mouse0.92089718
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.91648088
74* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.89007476
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86588962
76* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.86282572
77EST1_17652178_ChIP-ChIP_JURKAT_Human0.85369017
78NOTCH1_21737748_ChIP-Seq_TLL_Human0.84702699
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84013161
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83806333
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.83673167
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83534267
83* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83494761
84MYCN_18555785_ChIP-Seq_MESCs_Mouse0.82485616
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.80533363
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.79209081
87ZNF263_19887448_ChIP-Seq_K562_Human0.78302737
88NANOG_18555785_ChIP-Seq_MESCs_Mouse0.78007981
89DCP1A_22483619_ChIP-Seq_HELA_Human0.76009654
90HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.75180321
91MAF_26560356_Chip-Seq_TH1_Human0.74901661
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74807631
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.73816574
94RUNX1_22412390_ChIP-Seq_EML_Mouse0.73698774
95POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.73388968
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72867598
97KDM5A_27292631_Chip-Seq_BREAST_Human0.72354212
98CIITA_25753668_ChIP-Seq_RAJI_Human0.72129429
99* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.71889925
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.71512925
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.71405447
102ETS1_20019798_ChIP-Seq_JURKAT_Human0.71054319
103UTX_26944678_Chip-Seq_JUKART_Human0.70735132
104PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.69718755
105HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.69319193
106YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.68253128
107SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.68200212
108MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.67999315
109MYB_21317192_ChIP-Seq_ERMYB_Mouse0.67273063
110ELF1_17652178_ChIP-ChIP_JURKAT_Human0.66870583
111* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.66506315
112TCF3_18692474_ChIP-Seq_MESCs_Mouse0.66492569
113TFEB_21752829_ChIP-Seq_HELA_Human0.65977315
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.65658206
115* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.64980191
116TTF2_22483619_ChIP-Seq_HELA_Human0.63478019
117MYB_26560356_Chip-Seq_TH1_Human0.62334048
118TP63_17297297_ChIP-ChIP_HaCaT_Human0.58546113
119GABP_19822575_ChIP-Seq_HepG2_Human0.57717734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo6.28472884
2MP0004147_increased_porphyrin_level6.01818665
3MP0010094_abnormal_chromosome_stability4.83498311
4MP0003111_abnormal_nucleus_morphology4.49074369
5MP0003693_abnormal_embryo_hatching3.87788014
6MP0010307_abnormal_tumor_latency3.77009610
7MP0003077_abnormal_cell_cycle3.75995424
8MP0004957_abnormal_blastocyst_morpholog2.87796466
9MP0008057_abnormal_DNA_replication2.67434680
10MP0003763_abnormal_thymus_physiology2.46971585
11MP0005083_abnormal_biliary_tract2.42966961
12MP0000569_abnormal_digit_pigmentation2.40011206
13MP0008058_abnormal_DNA_repair2.33190614
14MP0010352_gastrointestinal_tract_polyps2.31343190
15MP0005076_abnormal_cell_differentiation2.24997262
16MP0001661_extended_life_span2.20430544
17MP0000350_abnormal_cell_proliferation2.14164271
18MP0002396_abnormal_hematopoietic_system2.09742773
19MP0009697_abnormal_copulation2.08751858
20MP0004185_abnormal_adipocyte_glucose2.03806496
21MP0004808_abnormal_hematopoietic_stem1.98576022
22MP0003705_abnormal_hypodermis_morpholog1.92848527
23MP0001730_embryonic_growth_arrest1.80290861
24MP0000490_abnormal_crypts_of1.78341069
25MP0008932_abnormal_embryonic_tissue1.77756944
26MP0008007_abnormal_cellular_replicative1.70966320
27MP0006054_spinal_hemorrhage1.70867155
28MP0008877_abnormal_DNA_methylation1.63197787
29MP0002019_abnormal_tumor_incidence1.61217777
30MP0003300_gastrointestinal_ulcer1.60855843
31MP0002398_abnormal_bone_marrow1.58173584
32MP0000537_abnormal_urethra_morphology1.57701221
33MP0005397_hematopoietic_system_phenotyp1.57531594
34MP0001545_abnormal_hematopoietic_system1.57531594
35MP0005645_abnormal_hypothalamus_physiol1.54431588
36MP0002166_altered_tumor_susceptibility1.51949183
37MP0002877_abnormal_melanocyte_morpholog1.47525714
38MP0002722_abnormal_immune_system1.44755337
39MP0000313_abnormal_cell_death1.43019986
40MP0002009_preneoplasia1.39192028
41MP0000689_abnormal_spleen_morphology1.37760357
42MP0000703_abnormal_thymus_morphology1.36301621
43MP0002095_abnormal_skin_pigmentation1.33668700
44MP0005623_abnormal_meninges_morphology1.33296879
45MP0001697_abnormal_embryo_size1.31454297
46MP0002086_abnormal_extraembryonic_tissu1.30786046
47MP0002080_prenatal_lethality1.29079595
48MP0004197_abnormal_fetal_growth/weight/1.26350180
49MP0005380_embryogenesis_phenotype1.25364702
50MP0001672_abnormal_embryogenesis/_devel1.25364702
51MP0002160_abnormal_reproductive_system1.24121514
52MP0002006_tumorigenesis1.21757923
53MP0002429_abnormal_blood_cell1.18505358
54MP0010234_abnormal_vibrissa_follicle1.16995313
55MP0003786_premature_aging1.14933481
56MP0000465_gastrointestinal_hemorrhage1.13017540
57MP0005451_abnormal_body_composition1.12180839
58MP0000013_abnormal_adipose_tissue1.11074899
59MP0002697_abnormal_eye_size1.10923521
60MP0004233_abnormal_muscle_weight1.10659219
61MP0004381_abnormal_hair_follicle1.09891029
62MP0005220_abnormal_exocrine_pancreas1.09524653
63MP0003984_embryonic_growth_retardation1.08953087
64MP0000685_abnormal_immune_system1.08834954
65MP0003937_abnormal_limbs/digits/tail_de1.06902012
66MP0002088_abnormal_embryonic_growth/wei1.06596442
67MP0009379_abnormal_foot_pigmentation1.04961300
68MP0008770_decreased_survivor_rate1.04605768
69MP0003123_paternal_imprinting1.04443274
70MP0002084_abnormal_developmental_patter1.02569759
71MP0003121_genomic_imprinting1.00315333
72MP0002085_abnormal_embryonic_tissue0.99367177
73MP0001800_abnormal_humoral_immune0.97058933
74MP0005621_abnormal_cell_physiology0.93873763
75MP0000716_abnormal_immune_system0.93449905
76MP0002163_abnormal_gland_morphology0.91734810
77MP0006035_abnormal_mitochondrial_morpho0.89530517
78MP0003566_abnormal_cell_adhesion0.88983826
79MP0005384_cellular_phenotype0.88896273
80MP0002452_abnormal_antigen_presenting0.86577112
81MP0003787_abnormal_imprinting0.85931159
82MP0003303_peritoneal_inflammation0.85883439
83MP0002060_abnormal_skin_morphology0.83794111
84MP0008995_early_reproductive_senescence0.82528572
85MP0010030_abnormal_orbit_morphology0.81805092
86MP0000003_abnormal_adipose_tissue0.81777833
87MP0000372_irregular_coat_pigmentation0.81028643
88MP0005171_absent_coat_pigmentation0.80720208
89MP0000015_abnormal_ear_pigmentation0.80394622
90MP0005647_abnormal_sex_gland0.80369074
91MP0004947_skin_inflammation0.80231184
92MP0002420_abnormal_adaptive_immunity0.78979057
93MP0005501_abnormal_skin_physiology0.78662658
94MP0001819_abnormal_immune_cell0.77023943
95MP0000428_abnormal_craniofacial_morphol0.76879338
96MP0000383_abnormal_hair_follicle0.76698759
97MP0009703_decreased_birth_body0.76301178
98MP0009672_abnormal_birth_weight0.75681291
99MP0003448_altered_tumor_morphology0.74611399
100MP0001286_abnormal_eye_development0.72960150
101MP0000733_abnormal_muscle_development0.72121056
102MP0000358_abnormal_cell_content/0.69787936
103MP0009765_abnormal_xenobiotic_induced0.68833749
104MP0005266_abnormal_metabolism0.67773064
105MP0003385_abnormal_body_wall0.67377964
106MP0002332_abnormal_exercise_endurance0.66992771
107MP0001915_intracranial_hemorrhage0.66856880
108MP0001835_abnormal_antigen_presentation0.65723916
109MP0005464_abnormal_platelet_physiology0.65585206
110MP0009931_abnormal_skin_appearance0.65226438
111MP0001191_abnormal_skin_condition0.64073915
112MP0005391_vision/eye_phenotype0.63970488
113MP0005671_abnormal_response_to0.63290706
114MP0002111_abnormal_tail_morphology0.63081560
115MP0000371_diluted_coat_color0.62487207
116MP0002092_abnormal_eye_morphology0.62191196
117MP0002723_abnormal_immune_serum0.60335414
118MP0003890_abnormal_embryonic-extraembry0.60007530
119MP0003718_maternal_effect0.59454791
120MP0001879_abnormal_lymphatic_vessel0.58826733
121MP0002075_abnormal_coat/hair_pigmentati0.57853564
122MP0003453_abnormal_keratinocyte_physiol0.57505120
123MP0003436_decreased_susceptibility_to0.57261651
124MP0005408_hypopigmentation0.57157455
125MP0002405_respiratory_system_inflammati0.56677164
126MP0005023_abnormal_wound_healing0.56233531
127MP0001293_anophthalmia0.55766313
128MP0003186_abnormal_redox_activity0.55467652
129MP0009278_abnormal_bone_marrow0.55440555
130MP0003806_abnormal_nucleotide_metabolis0.54965883
131MP0008438_abnormal_cutaneous_collagen0.54065588
132MP0010678_abnormal_skin_adnexa0.53649190
133MP0000858_altered_metastatic_potential0.53574423
134MP0005636_abnormal_mineral_homeostasis0.53397316

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)9.80793748
2Abnormality of the heme biosynthetic pathway (HP:0010472)7.12434419
3Hypochromic microcytic anemia (HP:0004840)6.75882307
4Acanthocytosis (HP:0001927)5.98520830
5Colitis (HP:0002583)4.86804454
6Reticulocytosis (HP:0001923)4.81788680
7IgA deficiency (HP:0002720)4.72182631
8Cholelithiasis (HP:0001081)4.38619311
9Abnormality of reticulocytes (HP:0004312)4.26293882
10Chromsome breakage (HP:0040012)4.02210819
11Abnormal gallbladder morphology (HP:0012437)3.87125087
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.74258865
13Diaphragmatic weakness (HP:0009113)3.65177344
14Birth length less than 3rd percentile (HP:0003561)3.57170811
15Hypochromic anemia (HP:0001931)3.55911223
16Thyroiditis (HP:0100646)3.54755643
17Abnormality of chromosome stability (HP:0003220)3.54454165
18Insomnia (HP:0100785)3.37910969
19Cutaneous melanoma (HP:0012056)3.33821098
20Reticulocytopenia (HP:0001896)3.27636462
21Cutaneous photosensitivity (HP:0000992)3.21817921
22Impulsivity (HP:0100710)3.08873065
23B lymphocytopenia (HP:0010976)3.04137612
24High pitched voice (HP:0001620)2.97735665
25Aplasia/Hypoplasia of the sacrum (HP:0008517)2.86861490
26Volvulus (HP:0002580)2.86431717
27Prominent nose (HP:0000448)2.84686762
28Basal cell carcinoma (HP:0002671)2.81438791
29Microcytic anemia (HP:0001935)2.77801233
30Interstitial pulmonary disease (HP:0006530)2.77119254
31Paralysis (HP:0003470)2.73608726
32Hyperbilirubinemia (HP:0002904)2.72815176
33Microvesicular hepatic steatosis (HP:0001414)2.71119280
34Cafe-au-lait spot (HP:0000957)2.66108709
35Nephroblastoma (Wilms tumor) (HP:0002667)2.65278851
36Abnormality of cells of the erythroid lineage (HP:0012130)2.65190169
3711 pairs of ribs (HP:0000878)2.64950936
38Abnormality of the gallbladder (HP:0005264)2.62209583
39Squamous cell carcinoma (HP:0002860)2.61935158
40Small intestinal stenosis (HP:0012848)2.58305333
41Duodenal stenosis (HP:0100867)2.58305333
42Abnormality of the fingertips (HP:0001211)2.57142467
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.56167143
44Abnormality of the preputium (HP:0100587)2.55843814
45Deep philtrum (HP:0002002)2.53004552
46Papilledema (HP:0001085)2.52849511
47Agnosia (HP:0010524)2.50645441
48Inflammation of the large intestine (HP:0002037)2.47405996
49Abnormality of B cell number (HP:0010975)2.46869119
50Myelodysplasia (HP:0002863)2.45105201
51Meckel diverticulum (HP:0002245)2.43900057
52Embryonal renal neoplasm (HP:0011794)2.43713488
53Abnormal number of erythroid precursors (HP:0012131)2.40285822
54Entropion (HP:0000621)2.35092002
55Poikiloderma (HP:0001029)2.34091134
56Abnormality of DNA repair (HP:0003254)2.33341745
57Subacute progressive viral hepatitis (HP:0006572)2.32244558
58Macrocytic anemia (HP:0001972)2.31739015
59Abnormality of pyrimidine metabolism (HP:0004353)2.30613935
60Abnormality of the ileum (HP:0001549)2.29710705
61Osteomalacia (HP:0002749)2.27992537
62Verrucae (HP:0200043)2.26400773
63Papilloma (HP:0012740)2.26400773
64Autoimmune hemolytic anemia (HP:0001890)2.25807375
65Sloping forehead (HP:0000340)2.22851407
66Gastrointestinal inflammation (HP:0004386)2.22711375
67Pallor (HP:0000980)2.21649418
68Arteriovenous malformation (HP:0100026)2.21416251
69Hyperacusis (HP:0010780)2.21307751
70Prostate neoplasm (HP:0100787)2.20338789
71Short thumb (HP:0009778)2.18519413
72Hepatocellular carcinoma (HP:0001402)2.17208374
73Short chin (HP:0000331)2.17208078
74Abnormal gallbladder physiology (HP:0012438)2.15253489
75Cholecystitis (HP:0001082)2.15253489
76Renovascular hypertension (HP:0100817)2.14935461
77Broad distal phalanx of finger (HP:0009836)2.14589899
78Missing ribs (HP:0000921)2.14581885
79Ureteral duplication (HP:0000073)2.12153948
80Freckling (HP:0001480)2.10439103
81Selective tooth agenesis (HP:0001592)2.09808856
82Abnormality of the 4th metacarpal (HP:0010012)2.09089485
83Increased nuchal translucency (HP:0010880)2.08122910
84Rhabdomyosarcoma (HP:0002859)2.07281990
85Pustule (HP:0200039)2.05958033
86Abnormality of the distal phalanx of the thumb (HP:0009617)2.05373373
87Acute lymphatic leukemia (HP:0006721)2.02567860
88Abnormality of the labia minora (HP:0012880)2.00467444
89Global brain atrophy (HP:0002283)1.99242115
90Abnormality of the duodenum (HP:0002246)1.97360456
91Abnormality of the renal collecting system (HP:0004742)1.96126830
92Viral hepatitis (HP:0006562)1.96026817
93Asymmetry of the thorax (HP:0001555)1.95266447
94Cortical dysplasia (HP:0002539)1.94584684
95Ectopic kidney (HP:0000086)1.93928509
96Ependymoma (HP:0002888)1.93263787
97Spinal cord lesions (HP:0100561)1.93046977
98Syringomyelia (HP:0003396)1.93046977
99Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.92902016
100Sandal gap (HP:0001852)1.92869074
101Recurrent sinusitis (HP:0011108)1.92662844
102Absent frontal sinuses (HP:0002688)1.92145370
103Abnormal auditory evoked potentials (HP:0006958)1.90299755
104Cellulitis (HP:0100658)1.89891840
105Hypergonadotropic hypogonadism (HP:0000815)1.89762381
106Abnormality of the carotid arteries (HP:0005344)1.87575238
107IgM deficiency (HP:0002850)1.87571566
108Colon cancer (HP:0003003)1.87535602
109Acute myeloid leukemia (HP:0004808)1.87454361
110Thrombocytosis (HP:0001894)1.87440680
111Agammaglobulinemia (HP:0004432)1.86004402
112Heterotopia (HP:0002282)1.85997245
113Patellar aplasia (HP:0006443)1.85337697
114Proximal placement of thumb (HP:0009623)1.83633461
115Hypopigmentation of the fundus (HP:0007894)1.83169782
116Breast hypoplasia (HP:0003187)1.82984105
117Absent thumb (HP:0009777)1.81941795
118Conjunctival telangiectasia (HP:0000524)1.81664204
119Erythema (HP:0010783)1.81133034
120Spastic diplegia (HP:0001264)1.81054732
121Hyponatremia (HP:0002902)1.79306022
122Lymphoma (HP:0002665)1.79168100
123Biliary tract neoplasm (HP:0100574)1.79132901
124Microtia (HP:0008551)1.78811063
125Ulnar bowing (HP:0003031)1.78502718
126Abnormal platelet volume (HP:0011876)1.78262101
127Deviation of the thumb (HP:0009603)1.78075848
128Bicuspid aortic valve (HP:0001647)1.77879626
129Aplasia/Hypoplasia of the patella (HP:0006498)1.77400226
130Short 4th metacarpal (HP:0010044)1.76856933
131Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.76856933
132Long eyelashes (HP:0000527)1.76445749
133Medulloblastoma (HP:0002885)1.75742121
134Clubbing of toes (HP:0100760)1.74196123
135Astrocytoma (HP:0009592)1.73733844
136Abnormality of the astrocytes (HP:0100707)1.73733844
137Teleangiectasia of the skin (HP:0100585)1.73624038
138Slender long bone (HP:0003100)1.73224680
139Abnormality of the parietal bone (HP:0002696)1.73082365
140Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72512263
141Recurrent viral infections (HP:0004429)1.72439390
142Micronodular cirrhosis (HP:0001413)1.71674816
143Ankyloglossia (HP:0010296)1.71551331
144Petechiae (HP:0000967)1.69943185
145Short nail (HP:0001799)1.69819606
146Partial agenesis of the corpus callosum (HP:0001338)1.69550931
147Progressive external ophthalmoplegia (HP:0000590)1.68931597
148Increased mean platelet volume (HP:0011877)1.68477414
149Duplication of thumb phalanx (HP:0009942)1.68053158
150Dysmetric saccades (HP:0000641)1.67963830
151Papillary thyroid carcinoma (HP:0002895)1.67948689
152Rectal prolapse (HP:0002035)1.67725604
153Duplicated collecting system (HP:0000081)1.67663912
154Amaurosis fugax (HP:0100576)1.67405313
155Severe combined immunodeficiency (HP:0004430)1.66273587
156Combined immunodeficiency (HP:0005387)1.66077968
157Progressive muscle weakness (HP:0003323)1.65478018
158Osteolytic defects of the hand bones (HP:0009699)1.64899092
159Bone marrow hypocellularity (HP:0005528)1.64103798
160Neoplasm of the heart (HP:0100544)1.63738036
161Embryonal neoplasm (HP:0002898)1.63440587
162Leukopenia (HP:0001882)1.60535296

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK18.92633525
2ZAK6.13974541
3STK44.28545255
4VRK13.44092699
5CDC73.40531259
6CDK123.30213200
7RPS6KA52.86951515
8NEK22.31487923
9EIF2AK12.20217135
10SCYL22.06028050
11AURKB1.90738674
12MAP3K81.88250006
13PIM11.77090364
14WEE11.73773046
15MAP3K101.55436764
16CDK91.45474424
17BUB11.37916350
18TRIB31.36276927
19CHEK21.33663010
20DYRK31.32413281
21STK101.31543989
22EEF2K1.31391355
23BRD41.30853204
24TTK1.18500191
25GRK61.17232801
26CAMK1D1.14226669
27PLK11.12930434
28SMG11.12260639
29SRPK11.11594567
30NME21.10076819
31NEK11.08159575
32AURKA1.06904282
33PKN21.04189223
34PKN10.97192071
35CDK60.94642683
36ATR0.93382308
37BRSK20.90849527
38CDK40.88666501
39ICK0.86590185
40PIK3CG0.86110262
41PRKAA10.85149526
42RPS6KB20.81642480
43BTK0.79521210
44CDK80.78112122
45MAP2K30.75340735
46PBK0.74008054
47BRAF0.73335426
48CHEK10.72074548
49TTN0.71507365
50PLK30.71387926
51DYRK1B0.71365338
52BRSK10.71365247
53FLT30.67062857
54STK30.65640754
55DAPK30.65189533
56ATM0.64801639
57TRPM70.64270566
58KDR0.63214136
59PIM20.60891846
60TAF10.58534099
61EIF2AK20.58378959
62AKT30.57938855
63CDK70.56379417
64CDK20.55594132
65EIF2AK30.54808142
66MELK0.52748293
67PLK40.51485108
68MARK30.49623426
69AKT20.46793640
70CDK10.45973028
71MAP4K10.45210473
72CAMK40.45026170
73CCNB10.43613985
74RAF10.43610706
75FRK0.41994047
76CAMKK20.41377103
77MAP3K60.41096070
78PASK0.41036486
79NEK60.39363780
80LRRK20.38241484
81ACVR1B0.38233364
82JAK20.35210072
83MST1R0.33929366
84BCKDK0.33682006
85STK160.33450502
86SGK10.33224466
87PRPF4B0.32630241
88CSNK1D0.31229986
89MAP3K20.31222025
90IRAK30.30967776
91CAMK1G0.30507597
92BMX0.30321047
93MAP2K70.29589709
94CSNK1A1L0.28520241
95PRKCQ0.27497336
96OBSCN0.27367586
97CSNK1G10.27311761
98MAP3K110.26923474
99IRAK40.26538385
100NLK0.26467535
101FGR0.26432566
102MAPKAPK30.25062010
103MKNK10.25008826
104RPS6KA60.24852635
105RPS6KB10.24781481
106MAP3K40.24741505
107PRKDC0.24338190
108MAP2K40.23859032
109PRKCD0.23667370
110CSNK1G30.23585821
111IRAK20.22283613
112SYK0.22190207
113PAK10.22189302
114MAPK140.22060518
115MAP2K20.21128995
116AKT10.20886248
117PDK20.20523541
118ABL20.20233369
119TGFBR20.19377700
120RPS6KA10.19067631
121RPS6KA40.19007158
122LYN0.18843742
123CSF1R0.18823980
124MTOR0.18724007
125RET0.17601125
126MAPK110.17395885
127TYK20.15239809
128RPS6KA30.15185503
129CSNK2A20.14435848
130ERBB20.14232513
131TESK20.12838390
132SGK30.11756243
133TEC0.11496127
134CSNK2A10.10104851
135IKBKB0.09663390
136PRKCB0.08839166
137ALK0.08101417
138NEK90.06700192
139MAPK10.06573552
140RPS6KC10.06484465
141RPS6KL10.06484465

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.29467057
2Viral carcinogenesis_Homo sapiens_hsa052033.43059772
3DNA replication_Homo sapiens_hsa030303.06601616
4Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.57776001
5Mismatch repair_Homo sapiens_hsa034302.48200064
6Cell cycle_Homo sapiens_hsa041102.17217394
7* Systemic lupus erythematosus_Homo sapiens_hsa0532211.2907013
8One carbon pool by folate_Homo sapiens_hsa006701.80727980
9Fanconi anemia pathway_Homo sapiens_hsa034601.71181378
10Base excision repair_Homo sapiens_hsa034101.68365078
11Homologous recombination_Homo sapiens_hsa034401.66823392
12Non-homologous end-joining_Homo sapiens_hsa034501.62922845
13Nucleotide excision repair_Homo sapiens_hsa034201.55667860
14Transcriptional misregulation in cancer_Homo sapiens_hsa052021.53735507
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43785215
16RNA transport_Homo sapiens_hsa030131.35562015
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23607855
18Spliceosome_Homo sapiens_hsa030401.21189643
19p53 signaling pathway_Homo sapiens_hsa041151.20905757
20Ribosome_Homo sapiens_hsa030101.19623798
21Pyrimidine metabolism_Homo sapiens_hsa002400.86084387
22Malaria_Homo sapiens_hsa051440.81363994
23Sulfur relay system_Homo sapiens_hsa041220.80662243
24Herpes simplex infection_Homo sapiens_hsa051680.77748634
25Small cell lung cancer_Homo sapiens_hsa052220.74993571
26mRNA surveillance pathway_Homo sapiens_hsa030150.74640424
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74118246
28Antigen processing and presentation_Homo sapiens_hsa046120.74025226
29MicroRNAs in cancer_Homo sapiens_hsa052060.69797919
30Hematopoietic cell lineage_Homo sapiens_hsa046400.68126730
31Apoptosis_Homo sapiens_hsa042100.67913265
32Selenocompound metabolism_Homo sapiens_hsa004500.66035044
33Non-small cell lung cancer_Homo sapiens_hsa052230.65369363
34Oocyte meiosis_Homo sapiens_hsa041140.64932743
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64158143
36RNA polymerase_Homo sapiens_hsa030200.61529726
37RNA degradation_Homo sapiens_hsa030180.58073601
38Chronic myeloid leukemia_Homo sapiens_hsa052200.58049302
39Epstein-Barr virus infection_Homo sapiens_hsa051690.58042407
40HTLV-I infection_Homo sapiens_hsa051660.54516343
41Hepatitis B_Homo sapiens_hsa051610.52623322
42Acute myeloid leukemia_Homo sapiens_hsa052210.48810499
43Measles_Homo sapiens_hsa051620.47561965
44Bladder cancer_Homo sapiens_hsa052190.45571406
45Basal cell carcinoma_Homo sapiens_hsa052170.45177204
46Folate biosynthesis_Homo sapiens_hsa007900.43877797
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.43596762
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42351552
49Pancreatic cancer_Homo sapiens_hsa052120.41840278
50B cell receptor signaling pathway_Homo sapiens_hsa046620.40050128
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37967097
52Proteasome_Homo sapiens_hsa030500.37788362
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36677560
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36534534
55Basal transcription factors_Homo sapiens_hsa030220.35489585
56Lysine degradation_Homo sapiens_hsa003100.34539219
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33889180
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32553574
59Vitamin B6 metabolism_Homo sapiens_hsa007500.32326100
60ErbB signaling pathway_Homo sapiens_hsa040120.31488795
61N-Glycan biosynthesis_Homo sapiens_hsa005100.31225457
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30133294
63Prostate cancer_Homo sapiens_hsa052150.29823585
64FoxO signaling pathway_Homo sapiens_hsa040680.29337642
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27851486
66Influenza A_Homo sapiens_hsa051640.27746789
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26903000
68Glioma_Homo sapiens_hsa052140.25517762
69Purine metabolism_Homo sapiens_hsa002300.25045105
70ABC transporters_Homo sapiens_hsa020100.24758610
71VEGF signaling pathway_Homo sapiens_hsa043700.23715588
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23425146
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23416606
74Leishmaniasis_Homo sapiens_hsa051400.23353772
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.22363471
76TGF-beta signaling pathway_Homo sapiens_hsa043500.21392116
77mTOR signaling pathway_Homo sapiens_hsa041500.21365835
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21229590
79Pentose phosphate pathway_Homo sapiens_hsa000300.20576724
80Legionellosis_Homo sapiens_hsa051340.19994367
81Dorso-ventral axis formation_Homo sapiens_hsa043200.19866073
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.19219881
83Hedgehog signaling pathway_Homo sapiens_hsa043400.18978340
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.18766215
85Renin-angiotensin system_Homo sapiens_hsa046140.18463543
86Osteoclast differentiation_Homo sapiens_hsa043800.18303838
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18298697
88Primary immunodeficiency_Homo sapiens_hsa053400.18223044
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.17630355
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16827673
91Carbon metabolism_Homo sapiens_hsa012000.16672081
92Pathways in cancer_Homo sapiens_hsa052000.16457496
93Prolactin signaling pathway_Homo sapiens_hsa049170.15608190
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.15605554
95Galactose metabolism_Homo sapiens_hsa000520.15581873
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.14368700
97Melanoma_Homo sapiens_hsa052180.14234203
98Colorectal cancer_Homo sapiens_hsa052100.14153391
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.14085600
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.13638601
101Asthma_Homo sapiens_hsa053100.13344586
102Fructose and mannose metabolism_Homo sapiens_hsa000510.13213521
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13185830
104Arginine biosynthesis_Homo sapiens_hsa002200.13182249
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12895727
106Hippo signaling pathway_Homo sapiens_hsa043900.12797598
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12687914
108Biosynthesis of amino acids_Homo sapiens_hsa012300.12402670
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12078163
110Caffeine metabolism_Homo sapiens_hsa002320.11914870
111Toxoplasmosis_Homo sapiens_hsa051450.10904110
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.10215749
113Thyroid cancer_Homo sapiens_hsa052160.09233206
114Tuberculosis_Homo sapiens_hsa051520.08729461
115HIF-1 signaling pathway_Homo sapiens_hsa040660.08226618
116AMPK signaling pathway_Homo sapiens_hsa041520.07609761
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.07300680
118Platelet activation_Homo sapiens_hsa046110.06733879
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.06501507
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.05862087
121Notch signaling pathway_Homo sapiens_hsa043300.05716409
122Proteoglycans in cancer_Homo sapiens_hsa052050.05420686
123Huntingtons disease_Homo sapiens_hsa050160.05173736
124Autoimmune thyroid disease_Homo sapiens_hsa053200.04709690
125Hepatitis C_Homo sapiens_hsa051600.04328362
126Endometrial cancer_Homo sapiens_hsa052130.03997362
127Inositol phosphate metabolism_Homo sapiens_hsa005620.03983509
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.03877489

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