HIST2H2BB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome assembly (GO:0006335)8.07875119
2DNA replication-dependent nucleosome organization (GO:0034723)8.07875119
3regulation of histone H3-K9 methylation (GO:0051570)7.11982336
4chromatin assembly (GO:0031497)6.97311094
5nuclear pore complex assembly (GO:0051292)6.84057269
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.79519287
7nuclear pore organization (GO:0006999)6.58858620
8nucleosome assembly (GO:0006334)6.39426888
9DNA unwinding involved in DNA replication (GO:0006268)6.35411465
10mitotic chromosome condensation (GO:0007076)6.16977441
11protein localization to kinetochore (GO:0034501)5.80631696
12sister chromatid segregation (GO:0000819)5.61905572
13nucleosome organization (GO:0034728)5.45547273
14chromatin assembly or disassembly (GO:0006333)5.38305739
15protein-DNA complex assembly (GO:0065004)5.37095611
16pore complex assembly (GO:0046931)5.32287435
17replicative senescence (GO:0090399)4.93800733
18mitotic sister chromatid segregation (GO:0000070)4.81615439
19antibacterial humoral response (GO:0019731)4.78842303
20protein localization to chromosome, centromeric region (GO:0071459)4.74690280
21protein-DNA complex subunit organization (GO:0071824)4.74235516
22folic acid-containing compound biosynthetic process (GO:0009396)4.73156630
23cGMP-mediated signaling (GO:0019934)4.65552385
24nucleobase-containing small molecule interconversion (GO:0015949)4.57580956
25innate immune response in mucosa (GO:0002227)4.52344389
26DNA geometric change (GO:0032392)4.45825899
27DNA duplex unwinding (GO:0032508)4.45430070
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.43572407
29antimicrobial humoral response (GO:0019730)4.42342041
30kinetochore organization (GO:0051383)4.38119910
31mitotic sister chromatid cohesion (GO:0007064)4.37976618
32chromatin remodeling at centromere (GO:0031055)4.35598285
33regulation of DNA endoreduplication (GO:0032875)4.31466881
34CENP-A containing nucleosome assembly (GO:0034080)4.26402309
35regulation of centriole replication (GO:0046599)4.25475861
36DNA replication initiation (GO:0006270)4.25419623
37chromosome condensation (GO:0030261)4.24821798
38positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.18115851
39positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.18115851
40positive regulation of mitotic sister chromatid separation (GO:1901970)4.18115851
41negative regulation of vascular permeability (GO:0043116)4.15537297
42negative regulation of histone methylation (GO:0031061)4.14556073
43mitotic nuclear envelope disassembly (GO:0007077)4.14102922
44ribosomal small subunit biogenesis (GO:0042274)4.09622337
45positive regulation of chromosome segregation (GO:0051984)4.05223426
46protein K6-linked ubiquitination (GO:0085020)4.04637892
47dosage compensation (GO:0007549)4.03232253
48DNA topological change (GO:0006265)4.00891544
49positive regulation of vascular permeability (GO:0043117)3.97211171
50DNA strand elongation involved in DNA replication (GO:0006271)3.95995044
51membrane disassembly (GO:0030397)3.95930908
52nuclear envelope disassembly (GO:0051081)3.95930908
53IMP biosynthetic process (GO:0006188)3.95283571
54regulation of centrosome cycle (GO:0046605)3.93793281
55meiotic chromosome segregation (GO:0045132)3.92449435
56mitotic recombination (GO:0006312)3.90177483
57regulation of spindle organization (GO:0090224)3.86316834
58DNA replication-independent nucleosome organization (GO:0034724)3.83083411
59DNA replication-independent nucleosome assembly (GO:0006336)3.83083411
60regulation of RNA export from nucleus (GO:0046831)3.82502727
61IMP metabolic process (GO:0046040)3.75335644
62regulation of mitotic spindle organization (GO:0060236)3.74037801
63DNA strand elongation (GO:0022616)3.73741074
64protein complex localization (GO:0031503)3.72133978
65ribosomal small subunit assembly (GO:0000028)3.71329223
66chaperone mediated protein folding requiring cofactor (GO:0051085)3.70017839
67cellular protein complex localization (GO:0034629)3.69368353
68DNA conformation change (GO:0071103)3.67686067
69translesion synthesis (GO:0019985)3.64760915
70regulation of sister chromatid cohesion (GO:0007063)3.64318538
71regulation of translational fidelity (GO:0006450)3.62754520
72DNA packaging (GO:0006323)3.61230851
73regulation of centrosome duplication (GO:0010824)3.60636102
74telomere maintenance via semi-conservative replication (GO:0032201)3.55812186
75notochord development (GO:0030903)3.54229361
76histone exchange (GO:0043486)3.53669895
77regulation of chromosome segregation (GO:0051983)3.47318108
78attachment of spindle microtubules to kinetochore (GO:0008608)3.46346614
79spindle checkpoint (GO:0031577)3.45374695
80regulation of mitotic metaphase/anaphase transition (GO:0030071)3.43130140
81mucosal immune response (GO:0002385)3.43001695
82mitotic metaphase plate congression (GO:0007080)3.42285018
83regulation of gene silencing (GO:0060968)3.42136945
84telomere maintenance via recombination (GO:0000722)3.40584527
85spindle assembly involved in mitosis (GO:0090307)3.39970427
86positive regulation of histone methylation (GO:0031062)3.39389146
87heterochromatin organization (GO:0070828)3.39386957
88postreplication repair (GO:0006301)3.39281565
89natural killer cell mediated immunity (GO:0002228)3.37513059
90natural killer cell mediated cytotoxicity (GO:0042267)3.37513059
91metaphase plate congression (GO:0051310)3.35879026
92UV protection (GO:0009650)3.35828106
93regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.33847173
94chromosome segregation (GO:0007059)3.33351656
95spindle assembly checkpoint (GO:0071173)3.31184255
96establishment of chromosome localization (GO:0051303)3.24296888
97organ or tissue specific immune response (GO:0002251)3.22823873
98mitotic DNA integrity checkpoint (GO:0044774)3.22797713
99DNA synthesis involved in DNA repair (GO:0000731)3.18172235
100regulation of sister chromatid segregation (GO:0033045)3.17639802
101regulation of mitotic sister chromatid separation (GO:0010965)3.17639802
102regulation of mitotic sister chromatid segregation (GO:0033047)3.17639802
103folic acid metabolic process (GO:0046655)3.17212649
104resolution of meiotic recombination intermediates (GO:0000712)3.16939583
105protein localization to chromosome (GO:0034502)3.16779534
106negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.13948107
107deoxyribonucleotide biosynthetic process (GO:0009263)3.11972152
108mitotic spindle checkpoint (GO:0071174)3.11779968
109telomere maintenance (GO:0000723)3.11473549
110regulation of helicase activity (GO:0051095)3.11420758
111kidney mesenchyme development (GO:0072074)3.09351488
112positive regulation of histone H3-K4 methylation (GO:0051571)3.08457994
113negative regulation of chromosome segregation (GO:0051985)3.08406228
114regulation of nucleobase-containing compound transport (GO:0032239)3.07265723
115telomere organization (GO:0032200)3.06191205
116histone-serine phosphorylation (GO:0035404)3.06108690
117negative regulation of DNA repair (GO:0045738)3.05151859
118regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.04927417
119nucleotide-excision repair, DNA gap filling (GO:0006297)3.04389380
120mitotic spindle assembly checkpoint (GO:0007094)3.03858786
121cell adhesion mediated by integrin (GO:0033627)2.97282162
122centrosome duplication (GO:0051298)2.96039020
123histone phosphorylation (GO:0016572)2.91371530
124oocyte maturation (GO:0001556)2.88657697
125ribosome assembly (GO:0042255)2.88215677
126protein destabilization (GO:0031648)2.82573724
127mitochondrial fusion (GO:0008053)2.79898758
128negative regulation of T cell differentiation in thymus (GO:0033085)2.77882755
129microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.76370090
130viral transcription (GO:0019083)2.74399642
131negative regulation of inclusion body assembly (GO:0090084)2.73506731
132rRNA transcription (GO:0009303)2.72704118
133binding of sperm to zona pellucida (GO:0007339)2.66993203
134cAMP catabolic process (GO:0006198)2.63197117
135mitotic cytokinesis (GO:0000281)2.62046910
136maturation of SSU-rRNA (GO:0030490)2.61525983
137translational termination (GO:0006415)2.60943756
138cellular response to heat (GO:0034605)2.60048004
139ventricular cardiac muscle cell development (GO:0055015)2.59467853
140ribonucleoprotein complex biogenesis (GO:0022613)2.59355011
141positive regulation of digestive system process (GO:0060456)2.58377650
142TOR signaling (GO:0031929)2.57717077
143regulation of retinoic acid receptor signaling pathway (GO:0048385)2.55479719
144establishment of mitotic spindle localization (GO:0040001)2.53743076
145mesenchymal-epithelial cell signaling (GO:0060638)2.53066273
146positive regulation of muscle cell apoptotic process (GO:0010661)2.47622542
147regulation of urine volume (GO:0035809)2.47522603
148positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.45319188
149wound healing, spreading of epidermal cells (GO:0035313)2.44211914

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.61769366
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.94479480
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.42981502
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.07428114
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.46364213
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.63215436
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57103703
8E2F1_21310950_ChIP-Seq_MCF-7_Human2.24443571
9* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.16769862
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.11757005
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.08892299
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.05970421
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse15.2647039
14NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96958294
15EGR1_19374776_ChIP-ChIP_THP-1_Human1.93073742
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92980038
17* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90556073
18* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.88169942
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.84306487
20SOX2_16153702_ChIP-ChIP_HESCs_Human1.84064222
21AR_21909140_ChIP-Seq_LNCAP_Human1.80337679
22* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.74590477
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73897618
24* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73052875
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.68114726
26SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.64106810
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.55103979
28ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49866799
29ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.49275978
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47190094
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45555228
32ELK1_19687146_ChIP-ChIP_HELA_Human1.43156429
33IRF1_19129219_ChIP-ChIP_H3396_Human1.42932309
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41188216
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.40900475
36VDR_23849224_ChIP-Seq_CD4+_Human1.36579374
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34568965
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33602042
39* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31324098
40SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29627882
41ZNF263_19887448_ChIP-Seq_K562_Human1.28688118
42* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28530989
43HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.27589227
44* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23915463
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23217619
46* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19895049
47TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17306164
48* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16575026
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14637404
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12192487
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07516118
52NANOG_16153702_ChIP-ChIP_HESCs_Human1.07349192
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05218091
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04859812
55* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.00165903
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99514998
57JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97522035
58FOXP3_21729870_ChIP-Seq_TREG_Human0.96442350
59KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95920909
60MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95732412
61MYC_22102868_ChIP-Seq_BL_Human0.95637953
62E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95394555
63CLOCK_20551151_ChIP-Seq_293T_Human0.95317398
64CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95018868
65STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95009182
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94644427
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94644427
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94403212
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93798238
70XRN2_22483619_ChIP-Seq_HELA_Human0.92388107
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91661435
72BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90480586
73CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90112744
74ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89192631
75* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.88298749
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86563280
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85443040
78TCF3_18692474_ChIP-Seq_MESCs_Mouse0.84882226
79UBF1/2_26484160_Chip-Seq_HMECs_Human0.84271807
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.83202309
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82584636
82NANOG_18555785_ChIP-Seq_MESCs_Mouse0.80849149
83EST1_17652178_ChIP-ChIP_JURKAT_Human0.79617588
84* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.78640741
85HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.77978961
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77882405
87* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.76599893
88ATF3_27146783_Chip-Seq_COLON_Human0.75650064
89KDM5A_27292631_Chip-Seq_BREAST_Human0.75473336
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.74445164
91CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.73794140
92PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.73464064
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.73461920
94RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.72818237
95RARG_19884340_ChIP-ChIP_MEFs_Mouse0.72081530
96MYC_18940864_ChIP-ChIP_HL60_Human0.71937574
97* SOX17_20123909_ChIP-Seq_XEN_Mouse0.70782246
98ELK3_25401928_ChIP-Seq_HUVEC_Human0.69922842
99GATA1_22025678_ChIP-Seq_K562_Human0.69882572
100* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.69719100
101ETS1_20019798_ChIP-Seq_JURKAT_Human0.67886611
102VDR_21846776_ChIP-Seq_THP-1_Human0.67528926
103PKCTHETA_26484144_Chip-Seq_BREAST_Human0.67371556
104* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.67151815
105TP53_22127205_ChIP-Seq_IMR90_Human0.66887442
106* THAP11_20581084_ChIP-Seq_MESCs_Mouse0.66053612
107HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.64714144
108TTF2_22483619_ChIP-Seq_HELA_Human0.62459712
109SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.62226677
110BRD4_25478319_ChIP-Seq_HGPS_Human0.61847407
111TFEB_21752829_ChIP-Seq_HELA_Human0.61564112
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.61321713
113ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.61269529
114GABP_17652178_ChIP-ChIP_JURKAT_Human0.61102440
115MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.60760496
116GATA2_22383799_ChIP-Seq_G1ME_Mouse0.60311025
117SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.58951779
118SOX9_26525672_Chip-Seq_HEART_Mouse0.58801732
119GATA1_26923725_Chip-Seq_HPCs_Mouse0.58775237
120DCP1A_22483619_ChIP-Seq_HELA_Human0.58282875
121E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.57654312
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.57155570
123* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.57075479
124SALL4_22934838_ChIP-ChIP_CD34+_Human0.56192312
125CIITA_25753668_ChIP-Seq_RAJI_Human0.55644826
126FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.53520451
127NANOG_21062744_ChIP-ChIP_HESCs_Human0.52793629

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.06388056
2MP0010307_abnormal_tumor_latency4.30047547
3MP0003111_abnormal_nucleus_morphology4.03209374
4MP0003693_abnormal_embryo_hatching3.99010550
5MP0003077_abnormal_cell_cycle3.64355763
6MP0003705_abnormal_hypodermis_morpholog3.27231602
7MP0010234_abnormal_vibrissa_follicle3.19027152
8MP0004957_abnormal_blastocyst_morpholog3.15405383
9MP0010352_gastrointestinal_tract_polyps3.10180825
10MP0008057_abnormal_DNA_replication2.80158264
11MP0004272_abnormal_basement_membrane2.70662543
12MP0003123_paternal_imprinting2.58231887
13MP0008058_abnormal_DNA_repair2.37453064
14MP0000013_abnormal_adipose_tissue2.30519834
15MP0001730_embryonic_growth_arrest2.29073553
16MP0008932_abnormal_embryonic_tissue2.27366309
17MP0005076_abnormal_cell_differentiation2.21003524
18MP0005171_absent_coat_pigmentation2.15036435
19MP0003121_genomic_imprinting2.14553098
20MP0008007_abnormal_cellular_replicative2.14354010
21MP0000350_abnormal_cell_proliferation2.10551545
22MP0006054_spinal_hemorrhage2.07215019
23MP0001661_extended_life_span2.05057663
24MP0005503_abnormal_tendon_morphology2.02866982
25MP0000762_abnormal_tongue_morphology2.01620846
26MP0002396_abnormal_hematopoietic_system1.95468523
27MP0002160_abnormal_reproductive_system1.88140609
28MP0000372_irregular_coat_pigmentation1.85881723
29MP0008877_abnormal_DNA_methylation1.78717465
30MP0004197_abnormal_fetal_growth/weight/1.76938529
31MP0000537_abnormal_urethra_morphology1.74633372
32MP0010030_abnormal_orbit_morphology1.74061304
33MP0000569_abnormal_digit_pigmentation1.70179003
34MP0004808_abnormal_hematopoietic_stem1.69824667
35MP0001188_hyperpigmentation1.68890285
36MP0009697_abnormal_copulation1.66115235
37MP0010368_abnormal_lymphatic_system1.66009515
38MP0008438_abnormal_cutaneous_collagen1.65440097
39MP0002086_abnormal_extraembryonic_tissu1.59681475
40MP0001697_abnormal_embryo_size1.58880083
41MP0002877_abnormal_melanocyte_morpholog1.56414914
42MP0002084_abnormal_developmental_patter1.55853037
43MP0005380_embryogenesis_phenotype1.54004166
44MP0001672_abnormal_embryogenesis/_devel1.54004166
45MP0002060_abnormal_skin_morphology1.48454434
46MP0002080_prenatal_lethality1.48232789
47MP0003566_abnormal_cell_adhesion1.44819727
48MP0000465_gastrointestinal_hemorrhage1.42493229
49MP0002085_abnormal_embryonic_tissue1.40577736
50MP0003315_abnormal_perineum_morphology1.38614043
51MP0003786_premature_aging1.35994665
52MP0003941_abnormal_skin_development1.32894560
53MP0010678_abnormal_skin_adnexa1.31913614
54MP0002019_abnormal_tumor_incidence1.31092951
55MP0002095_abnormal_skin_pigmentation1.31023721
56MP0000371_diluted_coat_color1.30511820
57MP0003890_abnormal_embryonic-extraembry1.30278219
58MP0003984_embryonic_growth_retardation1.30271599
59MP0000490_abnormal_crypts_of1.29713129
60MP0002088_abnormal_embryonic_growth/wei1.29091483
61MP0005408_hypopigmentation1.26389873
62MP0009379_abnormal_foot_pigmentation1.26121306
63MP0001293_anophthalmia1.24412661
64MP0003937_abnormal_limbs/digits/tail_de1.23465245
65MP0003300_gastrointestinal_ulcer1.20761591
66MP0000749_muscle_degeneration1.20050524
67MP0003950_abnormal_plasma_membrane1.19211019
68MP0003385_abnormal_body_wall1.17709593
69MP0002075_abnormal_coat/hair_pigmentati1.16824329
70MP0000313_abnormal_cell_death1.16443862
71MP0009250_abnormal_appendicular_skeleto1.15689881
72MP0003656_abnormal_erythrocyte_physiolo1.11799036
73MP0003787_abnormal_imprinting1.10857485
74MP0000733_abnormal_muscle_development1.10741980
75MP0004084_abnormal_cardiac_muscle1.08205368
76MP0000703_abnormal_thymus_morphology1.07546258
77MP0004147_increased_porphyrin_level1.06797875
78MP0002092_abnormal_eye_morphology1.05014141
79MP0009703_decreased_birth_body1.03904379
80MP0000579_abnormal_nail_morphology1.02952980
81MP0001915_intracranial_hemorrhage1.02917071
82MP0002090_abnormal_vision1.01517432
83MP0002269_muscular_atrophy1.01249404
84MP0002697_abnormal_eye_size0.97449637
85MP0002166_altered_tumor_susceptibility0.96533712
86MP0005623_abnormal_meninges_morphology0.96292960
87MP0000003_abnormal_adipose_tissue0.95726881
88MP0000747_muscle_weakness0.90951333
89MP0001348_abnormal_lacrimal_gland0.90764037
90MP0000428_abnormal_craniofacial_morphol0.90227002
91MP0005023_abnormal_wound_healing0.89999640
92MP0002722_abnormal_immune_system0.89141221
93MP0000627_abnormal_mammary_gland0.88873860
94MP0002009_preneoplasia0.88869039
95MP0002398_abnormal_bone_marrow0.87415431
96MP0003755_abnormal_palate_morphology0.87132117
97MP0001186_pigmentation_phenotype0.85894070
98MP0005384_cellular_phenotype0.85417721
99MP0005621_abnormal_cell_physiology0.85031659
100MP0002111_abnormal_tail_morphology0.84700789
101MP0000689_abnormal_spleen_morphology0.83448704
102MP0003567_abnormal_fetal_cardiomyocyte0.83311545
103MP0000015_abnormal_ear_pigmentation0.82989975
104MP0001929_abnormal_gametogenesis0.82715662
105MP0005501_abnormal_skin_physiology0.82161765
106MP0008770_decreased_survivor_rate0.81830935
107MP0005389_reproductive_system_phenotype0.81663879
108MP0005395_other_phenotype0.81166251
109MP0000383_abnormal_hair_follicle0.79623441
110MP0009672_abnormal_birth_weight0.78865119
111MP0002282_abnormal_trachea_morphology0.78856239
112MP0002006_tumorigenesis0.78628586
113MP0002163_abnormal_gland_morphology0.77699774
114MP0003699_abnormal_female_reproductive0.76448780
115MP0000759_abnormal_skeletal_muscle0.75081381
116MP0000049_abnormal_middle_ear0.74928600
117MP0002210_abnormal_sex_determination0.74280518
118MP0003091_abnormal_cell_migration0.73933083
119MP0005193_abnormal_anterior_eye0.72198511
120MP0003279_aneurysm0.72183845
121MP0001243_abnormal_dermal_layer0.71953011
122MP0000427_abnormal_hair_cycle0.71662889
123MP0003935_abnormal_craniofacial_develop0.70951658
124MP0000343_altered_response_to0.69858033
125MP0004185_abnormal_adipocyte_glucose0.69037393
126MP0004233_abnormal_muscle_weight0.68445719
127MP0005410_abnormal_fertilization0.67839307
128MP0000358_abnormal_cell_content/0.65933757
129MP0003718_maternal_effect0.64248844
130MP0005275_abnormal_skin_tensile0.63138887
131MP0002925_abnormal_cardiovascular_devel0.62236474
132MP0003453_abnormal_keratinocyte_physiol0.61798085
133MP0001216_abnormal_epidermal_layer0.61281404
134MP0000432_abnormal_head_morphology0.60835468
135MP0002114_abnormal_axial_skeleton0.60143156
136MP0002429_abnormal_blood_cell0.59848625
137MP0003806_abnormal_nucleotide_metabolis0.59663736
138MP0005187_abnormal_penis_morphology0.59344753
139MP0009053_abnormal_anal_canal0.58649711
140MP0006072_abnormal_retinal_apoptosis0.57504315
141MP0000377_abnormal_hair_follicle0.57481246
142MP0005391_vision/eye_phenotype0.56696332
143MP0003136_yellow_coat_color0.56543302
144MP0005397_hematopoietic_system_phenotyp0.54811588
145MP0001545_abnormal_hematopoietic_system0.54811588
146MP0001849_ear_inflammation0.54411823

Predicted human phenotypes

RankGene SetZ-score
1Cutaneous melanoma (HP:0012056)4.34876912
2Chromsome breakage (HP:0040012)3.94216298
3Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.92388221
4Volvulus (HP:0002580)3.83828602
5Abnormality of chromosome stability (HP:0003220)3.66367209
6Premature rupture of membranes (HP:0001788)3.66234431
7Osteolytic defects of the phalanges of the hand (HP:0009771)3.52594070
8Osteolytic defects of the hand bones (HP:0009699)3.52594070
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.49925481
10Short nail (HP:0001799)3.37796808
11Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.31738577
12Subacute progressive viral hepatitis (HP:0006572)3.28762814
13Ependymoma (HP:0002888)3.28593284
14Short humerus (HP:0005792)3.25578883
15Abnormality of the frontal sinuses (HP:0002687)3.22795623
16Impulsivity (HP:0100710)3.19539305
17Rhabdomyosarcoma (HP:0002859)3.18160933
18Sensory axonal neuropathy (HP:0003390)3.17380045
19Short chin (HP:0000331)3.14405140
20Reticulocytopenia (HP:0001896)3.13412815
21Hypopigmentation of the fundus (HP:0007894)3.10470727
22Agnosia (HP:0010524)3.08472892
23Natal tooth (HP:0000695)3.07837752
24Abnormality of the astrocytes (HP:0100707)3.01676119
25Astrocytoma (HP:0009592)3.01676119
26Spastic diplegia (HP:0001264)3.00190193
27Hypochromic microcytic anemia (HP:0004840)2.98557883
28Short clavicles (HP:0000894)2.96590788
29Aplasia/hypoplasia of the humerus (HP:0006507)2.96378045
30Achilles tendon contracture (HP:0001771)2.81510590
31Aortic regurgitation (HP:0001659)2.77898275
32Abnormality of the distal phalanges of the toes (HP:0010182)2.76661170
33Poikilocytosis (HP:0004447)2.75990277
34Hydroureter (HP:0000072)2.75898422
35Mitral stenosis (HP:0001718)2.72058213
36Wormian bones (HP:0002645)2.70786654
37Cafe-au-lait spot (HP:0000957)2.67952071
38Biliary tract neoplasm (HP:0100574)2.66746273
39Medulloblastoma (HP:0002885)2.66471799
40Difficulty climbing stairs (HP:0003551)2.64756419
41Absent frontal sinuses (HP:0002688)2.62523806
42Freckling (HP:0001480)2.61449713
43Increased nuchal translucency (HP:0010880)2.60621932
44High pitched voice (HP:0001620)2.57577017
45Cortical dysplasia (HP:0002539)2.55668507
46Basal cell carcinoma (HP:0002671)2.55592772
47Glioma (HP:0009733)2.55006654
48Cerebellar dysplasia (HP:0007033)2.53732794
49Deviation of the thumb (HP:0009603)2.53046300
50Abnormality of the labia minora (HP:0012880)2.52147172
51Hyperacusis (HP:0010780)2.52065404
52Proximal placement of thumb (HP:0009623)2.51045116
53Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.51044519
54Short 4th metacarpal (HP:0010044)2.51044519
55Aplasia/Hypoplasia of the clavicles (HP:0006710)2.50843326
56Hypercortisolism (HP:0001578)2.49569830
57Entropion (HP:0000621)2.48811116
58Selective tooth agenesis (HP:0001592)2.46713361
59Myelodysplasia (HP:0002863)2.44717109
60Prominent nose (HP:0000448)2.42216505
61Sandal gap (HP:0001852)2.42182216
62Radial bowing (HP:0002986)2.40470094
63Squamous cell carcinoma (HP:0002860)2.39560024
64Elbow flexion contracture (HP:0002987)2.38513546
65Amaurosis fugax (HP:0100576)2.36664778
66Ulnar bowing (HP:0003031)2.36066471
67Abnormality of the Achilles tendon (HP:0005109)2.34977222
68Colon cancer (HP:0003003)2.33783608
69Broad ribs (HP:0000885)2.33447090
70Birth length less than 3rd percentile (HP:0003561)2.32168032
71Duodenal stenosis (HP:0100867)2.31747700
72Small intestinal stenosis (HP:0012848)2.31747700
73Aplasia/Hypoplasia of the uvula (HP:0010293)2.30927681
74Bowing of the arm (HP:0006488)2.29481023
75Bowed forearm bones (HP:0003956)2.29481023
76Acanthocytosis (HP:0001927)2.29420741
77Shoulder girdle muscle weakness (HP:0003547)2.28911487
78Abnormality of the preputium (HP:0100587)2.28655811
79Sloping forehead (HP:0000340)2.25921018
80Renal duplication (HP:0000075)2.25911523
81Meckel diverticulum (HP:0002245)2.23192567
82Knee flexion contracture (HP:0006380)2.22414588
83Malignant gastrointestinal tract tumors (HP:0006749)2.21145460
84Gastrointestinal carcinoma (HP:0002672)2.21145460
85Multiple lipomas (HP:0001012)2.21117536
86Hematochezia (HP:0002573)2.14512854
87Bladder diverticulum (HP:0000015)2.13750628
88Papilledema (HP:0001085)2.13595022
89Abnormality of the ileum (HP:0001549)2.13220820
90Conjunctival telangiectasia (HP:0000524)2.12387710
91Poikiloderma (HP:0001029)2.11708854
92Abnormality of reticulocytes (HP:0004312)2.11443632
93Neoplasm of striated muscle (HP:0009728)2.10648094
94Neoplasm of the oral cavity (HP:0100649)2.10074515
95Exocrine pancreatic insufficiency (HP:0001738)2.08332226
96Syringomyelia (HP:0003396)2.07434610
97Spinal cord lesions (HP:0100561)2.07434610
98Fibular hypoplasia (HP:0003038)2.06079658
99Ovarian neoplasm (HP:0100615)2.05778368
100Broad distal phalanx of finger (HP:0009836)2.05380894
101Abnormality of cells of the erythroid lineage (HP:0012130)2.04777807
102Scapular winging (HP:0003691)2.04280231
103Abnormal ossification of hand bones (HP:0005921)2.04106691
104Abnormality of the shoulder girdle musculature (HP:0001435)2.01040014
105Prostate neoplasm (HP:0100787)2.00382628
106Increased density of long bones (HP:0006392)2.00208583
107Sparse lateral eyebrow (HP:0005338)1.99614461
108Abnormality of the carotid arteries (HP:0005344)1.98299786
109Thrombocytosis (HP:0001894)1.97174022
110Thyroiditis (HP:0100646)1.96896429
111Limb-girdle muscle atrophy (HP:0003797)1.96800542
112Orthostatic hypotension (HP:0001278)1.96210457
113Heterotopia (HP:0002282)1.95869359
114Tetraparesis (HP:0002273)1.94542529
115Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94447666
116Intestinal polyposis (HP:0200008)1.93806065
117Spinal rigidity (HP:0003306)1.91023773
118Truncal obesity (HP:0001956)1.89998307
119Abnormality of the vasculature of the conjunctiva (HP:0008054)1.89259117
120Cutis marmorata (HP:0000965)1.87496815
121Fragile skin (HP:0001030)1.87262826
122Abnormality of the duodenum (HP:0002246)1.86604244
123Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.86478544
124Abnormality of the calcaneus (HP:0008364)1.85522429
125Abnormality of the humerus (HP:0003063)1.84795571
126Renovascular hypertension (HP:0100817)1.83459593
127Pelvic girdle muscle weakness (HP:0003749)1.83361877
128Carpal synostosis (HP:0009702)1.83014051
129Adenoma sebaceum (HP:0009720)1.82690622
130Angiofibromas (HP:0010615)1.82690622
131Abnormality of oral frenula (HP:0000190)1.82610466
132Intestinal polyp (HP:0005266)1.81755378
133Viral hepatitis (HP:0006562)1.81507177
134Abnormality of the right ventricle (HP:0001707)1.80511655
135Ureteral obstruction (HP:0006000)1.80226523
136Ureteral duplication (HP:0000073)1.80181031
137Neoplasm of the small intestine (HP:0100833)1.80176474
138Fibrous tissue neoplasm (HP:0012316)1.79300621
139Cerebral aneurysm (HP:0004944)1.79169282
140Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.78735414
141Premature graying of hair (HP:0002216)1.78713191
142Abnormality of the peritoneum (HP:0002585)1.78139814
143Papilloma (HP:0012740)1.77944431
144Verrucae (HP:0200043)1.77944431
145Abnormal number of erythroid precursors (HP:0012131)1.77740298
146Pancreatic islet-cell hyperplasia (HP:0004510)1.77726821
147Atrophic scars (HP:0001075)1.77695595
148Hyporeflexia of lower limbs (HP:0002600)1.77225787
149Reduced subcutaneous adipose tissue (HP:0003758)1.77210083
150Abnormality of the musculature of the pelvis (HP:0001469)1.76911933
151Abnormality of the hip-girdle musculature (HP:0001445)1.76911933
152Relative macrocephaly (HP:0004482)1.76835785
153Abnormality of the proximal phalanges of the hand (HP:0009834)1.76739555
154Abnormality of the umbilical cord (HP:0010881)1.76677728
155Wrist flexion contracture (HP:0001239)1.76650414
156Ankle contracture (HP:0006466)1.75867498
157Uterine neoplasm (HP:0010784)1.75784687
158Low anterior hairline (HP:0000294)1.75264543
159Abnormality of the tricuspid valve (HP:0001702)1.75204820
160Absent thumb (HP:0009777)1.74568754
161Bowel diverticulosis (HP:0005222)1.74525023
162Resting tremor (HP:0002322)1.74157044
163Ankyloglossia (HP:0010296)1.73956175
164Breast carcinoma (HP:0003002)1.73578078
165Synostosis of carpal bones (HP:0005048)1.72920579
166Atresia of the external auditory canal (HP:0000413)1.71998068
167Abnormality of the upper arm (HP:0001454)1.71502964
168Nephroblastoma (Wilms tumor) (HP:0002667)1.71413301
169Distal lower limb muscle weakness (HP:0009053)1.71147653
170Persistence of primary teeth (HP:0006335)1.70657567
171Abnormality of the 4th metacarpal (HP:0010012)1.66154177
172Aortic aneurysm (HP:0004942)1.65487387
173Aplasia/Hypoplasia of the fibula (HP:0006492)1.65209359

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK18.39740710
2ZAK6.01601812
3CDC74.00119687
4STK43.22407360
5VRK12.85244076
6RPS6KA52.58854368
7SCYL22.57020189
8NEK22.30476586
9PKN22.17295099
10ARAF2.09017942
11CDK82.02996537
12SRPK11.89445412
13MAP3K81.83853605
14AURKB1.83657903
15WEE11.82583009
16BRAF1.78822175
17MAP3K101.78574144
18EEF2K1.76300826
19CDK91.60150069
20NEK11.52169410
21TTN1.48498606
22CHEK21.47039979
23TTK1.46903496
24BUB11.41030401
25FRK1.37990053
26PIM11.36790336
27MAPKAPK51.34063666
28RPS6KB21.33073824
29CDK121.26102077
30ATR1.23004666
31MYLK1.22552086
32LATS21.22137739
33PLK11.22094644
34ERBB41.15844878
35STK101.13832801
36PLK31.13676526
37NEK91.13096586
38IRAK31.11092735
39MOS1.08617425
40PIM21.05784487
41MAPK150.99981821
42PASK0.98160680
43ACVR1B0.98108931
44EIF2AK10.95818309
45DYRK30.94510907
46AURKA0.93694280
47FLT30.92391621
48CAMK1D0.91767566
49CCNB10.89006514
50DAPK30.87228944
51TESK10.87205075
52CHEK10.87003491
53SMG10.86435167
54PKN10.86415962
55PDK20.86143761
56ATM0.85364098
57FGFR20.84855898
58CDK40.83981636
59ABL20.82573578
60ICK0.81052102
61GRK60.80037291
62EIF2AK30.78115582
63DYRK1B0.75427350
64TIE10.74486773
65TSSK60.72659907
66MST1R0.72385755
67BRSK20.71605042
68CAMKK20.70536592
69STK30.70331889
70LRRK20.68073378
71MAP2K70.67788932
72CDK20.67740222
73CDK60.66630827
74IRAK20.65576399
75MELK0.65497013
76PINK10.61569830
77MET0.60889644
78PRKCI0.59783628
79MAP3K130.59663265
80TGFBR10.58097286
81MKNK10.57903099
82CDK10.55293211
83BMPR20.55168062
84LIMK10.54241481
85TRIB30.53935892
86CSNK1D0.53600638
87MARK30.52221120
88BMX0.50253917
89AKT20.50180370
90ALK0.49855909
91STK240.48565058
92RPS6KA20.47739589
93CSNK1A1L0.47356988
94TRPM70.47197063
95FGR0.46916560
96PDGFRA0.45593777
97KSR10.42429609
98PRKAA10.42379477
99CSNK1G30.42233735
100PLK40.41079117
101PRKDC0.40917327
102PTK20.40373807
103EIF2AK20.39175508
104PAK20.38518635
105MAP3K60.38095600
106CDK70.37431300
107PRKG20.37159462
108RPS6KL10.36020011
109RPS6KC10.36020011
110PTK60.35340978
111CSF1R0.35095773
112NME20.34056416
113LATS10.33664986
114PIK3CG0.33519892
115MAP3K120.32188716
116MTOR0.31596086
117EPHA20.31467535
118CSNK2A20.30784268
119PAK40.30116223
120RPS6KA10.29748479
121TAF10.28767983
122PAK60.28416697
123RIPK10.28006157
124STK38L0.27771711
125MAPK140.27164248
126CLK10.26623337
127BRSK10.26565610
128PDGFRB0.26188259
129RPS6KA40.25015541
130PAK10.24812155
131CSNK1G10.24791350
132ERBB30.24543161
133FGFR30.23703054
134PBK0.23133786
135AKT10.22918783
136PRKCQ0.22489838
137ROCK10.21909926
138JAK20.21190986
139ILK0.18546640
140RAF10.17985988
141RPS6KB10.17198003
142FGFR10.17115097
143CAMK1G0.15496164
144TESK20.15043033
145CSNK1E0.14936528

Predicted pathways (KEGG)

RankGene SetZ-score
1Alcoholism_Homo sapiens_hsa050346.29094368
2Viral carcinogenesis_Homo sapiens_hsa052033.37270861
3DNA replication_Homo sapiens_hsa030303.02875103
4Mismatch repair_Homo sapiens_hsa034302.67112496
5One carbon pool by folate_Homo sapiens_hsa006702.23930479
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.09681633
7Cell cycle_Homo sapiens_hsa041102.07447606
8Non-homologous end-joining_Homo sapiens_hsa034502.06662453
9Systemic lupus erythematosus_Homo sapiens_hsa0532211.0814124
10RNA transport_Homo sapiens_hsa030131.79863252
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.76207942
12Fanconi anemia pathway_Homo sapiens_hsa034601.65502661
13Transcriptional misregulation in cancer_Homo sapiens_hsa052021.64305092
14Nucleotide excision repair_Homo sapiens_hsa034201.59454027
15Sulfur relay system_Homo sapiens_hsa041221.54284729
16Base excision repair_Homo sapiens_hsa034101.49785562
17Spliceosome_Homo sapiens_hsa030401.48990232
18Homologous recombination_Homo sapiens_hsa034401.48290064
19p53 signaling pathway_Homo sapiens_hsa041151.01796939
20mRNA surveillance pathway_Homo sapiens_hsa030150.99608060
21Ribosome_Homo sapiens_hsa030100.99188244
22Folate biosynthesis_Homo sapiens_hsa007900.97071025
23MicroRNAs in cancer_Homo sapiens_hsa052060.93852714
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87628215
25Gap junction_Homo sapiens_hsa045400.83901906
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83605288
27Selenocompound metabolism_Homo sapiens_hsa004500.82986345
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78024780
29Prion diseases_Homo sapiens_hsa050200.77733097
30Antigen processing and presentation_Homo sapiens_hsa046120.77528975
31Small cell lung cancer_Homo sapiens_hsa052220.76521417
32RNA degradation_Homo sapiens_hsa030180.76167048
33Pyrimidine metabolism_Homo sapiens_hsa002400.71029007
34Oocyte meiosis_Homo sapiens_hsa041140.69503855
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67494720
36Dilated cardiomyopathy_Homo sapiens_hsa054140.65258652
37HTLV-I infection_Homo sapiens_hsa051660.64024181
38Sulfur metabolism_Homo sapiens_hsa009200.62795034
39Chronic myeloid leukemia_Homo sapiens_hsa052200.59973265
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56917647
41Epstein-Barr virus infection_Homo sapiens_hsa051690.56719998
42Non-small cell lung cancer_Homo sapiens_hsa052230.56626338
43mTOR signaling pathway_Homo sapiens_hsa041500.55311736
44Ovarian steroidogenesis_Homo sapiens_hsa049130.54482431
45Central carbon metabolism in cancer_Homo sapiens_hsa052300.53615061
46Parkinsons disease_Homo sapiens_hsa050120.51508109
47RNA polymerase_Homo sapiens_hsa030200.51290722
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49733688
49Huntingtons disease_Homo sapiens_hsa050160.47956702
50Colorectal cancer_Homo sapiens_hsa052100.47161730
51Herpes simplex infection_Homo sapiens_hsa051680.46798758
52Alzheimers disease_Homo sapiens_hsa050100.46665384
53Apoptosis_Homo sapiens_hsa042100.46497680
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46182425
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44703540
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44246801
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43890280
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42710991
59Oxidative phosphorylation_Homo sapiens_hsa001900.41809146
60B cell receptor signaling pathway_Homo sapiens_hsa046620.41096735
61Hepatitis B_Homo sapiens_hsa051610.40524865
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38381457
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38280091
64Biosynthesis of amino acids_Homo sapiens_hsa012300.37457489
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37254568
66Glioma_Homo sapiens_hsa052140.37137916
67Pancreatic cancer_Homo sapiens_hsa052120.36735908
68Lysine degradation_Homo sapiens_hsa003100.36439655
69Legionellosis_Homo sapiens_hsa051340.36270819
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34582892
71Proteoglycans in cancer_Homo sapiens_hsa052050.34504788
72Prostate cancer_Homo sapiens_hsa052150.33813451
73Asthma_Homo sapiens_hsa053100.33292858
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33259181
75Thyroid cancer_Homo sapiens_hsa052160.33142726
76Vibrio cholerae infection_Homo sapiens_hsa051100.33118962
77Renin-angiotensin system_Homo sapiens_hsa046140.32963112
78Glutathione metabolism_Homo sapiens_hsa004800.32728675
79Hedgehog signaling pathway_Homo sapiens_hsa043400.30116047
80Bladder cancer_Homo sapiens_hsa052190.28628959
81Renin secretion_Homo sapiens_hsa049240.27834402
82Phagosome_Homo sapiens_hsa041450.26986611
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26839173
84Pentose phosphate pathway_Homo sapiens_hsa000300.26670199
85Melanoma_Homo sapiens_hsa052180.26379645
86Basal transcription factors_Homo sapiens_hsa030220.26121104
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.26008596
88Basal cell carcinoma_Homo sapiens_hsa052170.25708088
89Measles_Homo sapiens_hsa051620.25683493
90Focal adhesion_Homo sapiens_hsa045100.24911380
91Adherens junction_Homo sapiens_hsa045200.24162026
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.24052289
93Viral myocarditis_Homo sapiens_hsa054160.23657913
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23493910
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23409400
96FoxO signaling pathway_Homo sapiens_hsa040680.23170299
97Purine metabolism_Homo sapiens_hsa002300.23045787
98Endometrial cancer_Homo sapiens_hsa052130.22777709
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22454681
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.22111322
101TGF-beta signaling pathway_Homo sapiens_hsa043500.21884904
102Inositol phosphate metabolism_Homo sapiens_hsa005620.21623307
103HIF-1 signaling pathway_Homo sapiens_hsa040660.21445532
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19843924
105Vitamin B6 metabolism_Homo sapiens_hsa007500.19238286
106Protein digestion and absorption_Homo sapiens_hsa049740.18202411
107Proteasome_Homo sapiens_hsa030500.18183749
108Fatty acid biosynthesis_Homo sapiens_hsa000610.17661163
109Oxytocin signaling pathway_Homo sapiens_hsa049210.17160325
110Platelet activation_Homo sapiens_hsa046110.16263150
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.15782875
112Olfactory transduction_Homo sapiens_hsa047400.14934037
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14688013
114Pathways in cancer_Homo sapiens_hsa052000.14346233
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13985469
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.13403795
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.13140484
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.13118032
119Tight junction_Homo sapiens_hsa045300.12971946
120Hematopoietic cell lineage_Homo sapiens_hsa046400.12833415
121Sphingolipid metabolism_Homo sapiens_hsa006000.12740663
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12648495
123Influenza A_Homo sapiens_hsa051640.12530921
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.11347297
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10949013
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.10932197
127Hippo signaling pathway_Homo sapiens_hsa043900.10651620
128AMPK signaling pathway_Homo sapiens_hsa041520.08443433
129Toxoplasmosis_Homo sapiens_hsa051450.07840108
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.07573847
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.07486498
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.07438773
133Estrogen signaling pathway_Homo sapiens_hsa049150.07313842
134N-Glycan biosynthesis_Homo sapiens_hsa005100.06693199
135Osteoclast differentiation_Homo sapiens_hsa043800.06535089
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.06371616
137Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.05788736
138ECM-receptor interaction_Homo sapiens_hsa045120.05540224

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »