HIST2H2BC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is found in a histone cluster on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of B cell apoptotic process (GO:0002903)4.36116219
2innate immune response in mucosa (GO:0002227)4.21619729
3telomere maintenance via semi-conservative replication (GO:0032201)3.94881733
4DNA strand elongation involved in DNA replication (GO:0006271)3.83006778
5DNA strand elongation (GO:0022616)3.71781387
6deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.70592845
7regulation of B cell apoptotic process (GO:0002902)3.69361832
8immunoglobulin mediated immune response (GO:0016064)3.40607887
9mucosal immune response (GO:0002385)3.40215506
10telomere maintenance via recombination (GO:0000722)3.32402797
11dosage compensation (GO:0007549)3.27004485
12nucleotide-excision repair, DNA gap filling (GO:0006297)3.21476108
13organ or tissue specific immune response (GO:0002251)3.17879120
14mitotic recombination (GO:0006312)3.17769491
15DNA replication-dependent nucleosome assembly (GO:0006335)3.13863704
16DNA replication-dependent nucleosome organization (GO:0034723)3.13863704
17antibacterial humoral response (GO:0019731)3.12981505
18telomere maintenance via telomere lengthening (GO:0010833)3.07642713
19B cell mediated immunity (GO:0019724)3.07374984
20nucleosome assembly (GO:0006334)3.00539907
21antimicrobial humoral response (GO:0019730)2.96496626
22pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.89307504
23B cell receptor signaling pathway (GO:0050853)2.88891429
24definitive hemopoiesis (GO:0060216)2.87706633
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.87131447
26DNA unwinding involved in DNA replication (GO:0006268)2.85895127
27positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.79138977
28regulation of histone H3-K9 methylation (GO:0051570)2.74800529
29regulation of mitotic spindle checkpoint (GO:1903504)2.74344609
30regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.74344609
31G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.73262242
32chromatin assembly (GO:0031497)2.71979497
33negative regulation of erythrocyte differentiation (GO:0045647)2.71454975
34mannosylation (GO:0097502)2.68336264
35transcription-coupled nucleotide-excision repair (GO:0006283)2.67469115
36regulation of histone H3-K27 methylation (GO:0061085)2.64783012
37rRNA modification (GO:0000154)2.64666064
38viral mRNA export from host cell nucleus (GO:0046784)2.64335367
39nucleosome organization (GO:0034728)2.63251899
40regulation of spindle checkpoint (GO:0090231)2.63055104
41negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.60213126
42DNA deamination (GO:0045006)2.58696708
43DNA replication initiation (GO:0006270)2.58519004
44pseudouridine synthesis (GO:0001522)2.57517438
45regulation of DNA damage checkpoint (GO:2000001)2.56355004
46megakaryocyte development (GO:0035855)2.55559105
47protein-DNA complex assembly (GO:0065004)2.55319053
48positive regulation of B cell differentiation (GO:0045579)2.54174354
49response to peptidoglycan (GO:0032494)2.52979548
50regulation of cell cycle checkpoint (GO:1901976)2.52027275
51poly(A)+ mRNA export from nucleus (GO:0016973)2.51890712
52B cell homeostasis (GO:0001782)2.50706529
53neutrophil activation involved in immune response (GO:0002283)2.49562557
54peptidyl-arginine omega-N-methylation (GO:0035247)2.49167364
55T-helper 1 type immune response (GO:0042088)2.47090684
56folic acid-containing compound biosynthetic process (GO:0009396)2.45955088
57mitotic sister chromatid segregation (GO:0000070)2.45612508
58mature B cell differentiation involved in immune response (GO:0002313)2.44064291
59pentose metabolic process (GO:0019321)2.43434380
60negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.42797433
61ncRNA 3-end processing (GO:0043628)2.42756956
62response to muramyl dipeptide (GO:0032495)2.41835698
63proline biosynthetic process (GO:0006561)2.41243140
64pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.41179510
65hepatocyte apoptotic process (GO:0097284)2.40501745
66maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.38504589
67DNA topological change (GO:0006265)2.38018395
68UV protection (GO:0009650)2.37615557
69mitotic G1/S transition checkpoint (GO:0044819)2.37210562
70DNA duplex unwinding (GO:0032508)2.35933418
713-UTR-mediated mRNA stabilization (GO:0070935)2.33494742
72DNA synthesis involved in DNA repair (GO:0000731)2.32286980
73deoxyribonucleotide catabolic process (GO:0009264)2.31733210
74protein-DNA complex subunit organization (GO:0071824)2.30430195
75tRNA methylation (GO:0030488)2.29481910
76positive thymic T cell selection (GO:0045059)2.28701179
77negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.28668314
78negative thymic T cell selection (GO:0045060)2.28403949
79nucleotide-excision repair, DNA damage removal (GO:0000718)2.28351833
80DNA excision (GO:0044349)2.28351833
81purinergic nucleotide receptor signaling pathway (GO:0035590)2.26762005
82pentose-phosphate shunt (GO:0006098)2.24962836
83replication fork processing (GO:0031297)2.24535016
84telomere organization (GO:0032200)2.24111162
85cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.22556955
86sister chromatid segregation (GO:0000819)2.21853988
87deoxyribose phosphate catabolic process (GO:0046386)2.21716133
88telomere maintenance (GO:0000723)2.20484104
89DNA replication checkpoint (GO:0000076)2.20363382
90negative regulation of DNA-templated transcription, elongation (GO:0032785)2.20255657
91negative regulation of mRNA processing (GO:0050686)2.19766041
92rRNA methylation (GO:0031167)2.18517057
93DNA geometric change (GO:0032392)2.18500855
94negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.18497353
95regulation of centriole replication (GO:0046599)2.18430443
96regulation of histone H3-K4 methylation (GO:0051569)2.18085766
97mitotic metaphase plate congression (GO:0007080)2.16797177
98regulation of histone methylation (GO:0031060)2.16733825
99nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.15419309
100pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.14899366

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.42879447
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.46713427
3E2F4_17652178_ChIP-ChIP_JURKAT_Human2.63999367
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.63526527
5TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.61987884
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.59783518
7MYC_22102868_ChIP-Seq_BL_Human2.59377919
8VDR_21846776_ChIP-Seq_THP-1_Human2.41429022
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.25844744
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.24665441
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.20545303
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.16490727
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.14463432
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13075685
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09055355
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.05759697
17MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95299093
18TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.93788229
19MAF_26560356_Chip-Seq_TH1_Human1.84831050
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83599668
21MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82519410
22DCP1A_22483619_ChIP-Seq_HELA_Human1.81022262
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79009959
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.76780474
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.75461614
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73593670
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72873070
28DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.69578110
29CIITA_25753668_ChIP-Seq_RAJI_Human1.69157080
30XRN2_22483619_ChIP-Seq_HELA_Human1.68492095
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67459441
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65704885
33VDR_24763502_ChIP-Seq_THP-1_Human1.62072387
34HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.61717803
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.59813799
36VDR_23849224_ChIP-Seq_CD4+_Human1.59586443
37FOXP3_21729870_ChIP-Seq_TREG_Human1.58358521
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.56808540
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55512318
40ERG_20887958_ChIP-Seq_HPC-7_Mouse1.54818192
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53515436
42CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52882991
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52237114
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.50559389
45KDM5A_27292631_Chip-Seq_BREAST_Human1.49751676
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49675105
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48885710
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48373282
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.47306742
50UTX_26944678_Chip-Seq_JUKART_Human1.46819883
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46325790
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43246293
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43242340
54SPI1_23547873_ChIP-Seq_NB4_Human1.43028704
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42489001
56ZNF263_19887448_ChIP-Seq_K562_Human1.42475366
57SCL_19346495_ChIP-Seq_HPC-7_Human1.40948040
58EST1_17652178_ChIP-ChIP_JURKAT_Human1.39565863
59GABP_19822575_ChIP-Seq_HepG2_Human1.38165871
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36932270
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36214442
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.34789042
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.34424539
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34187634
65MAF_26560356_Chip-Seq_TH2_Human1.33671559
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33461815
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.32883683
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32476554
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.31432018
70E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29345127
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29275771
72MYB_26560356_Chip-Seq_TH1_Human1.29048950
73TFEB_21752829_ChIP-Seq_HELA_Human1.28153790
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28008994
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25913339
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25841309
77NCOR1_26117541_ChIP-Seq_K562_Human1.25482634
78E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24910766
79TCF7_22412390_ChIP-Seq_EML_Mouse1.24849977
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24370791
81MYB_26560356_Chip-Seq_TH2_Human1.23269302
82MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23120120
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21936493
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21065870
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.21039314
86EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19821204
87TTF2_22483619_ChIP-Seq_HELA_Human1.17563202
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17367608
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15752119
90SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14046667
91P68_20966046_ChIP-Seq_HELA_Human1.13996847
92NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12832423
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10239084
94GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10041172
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.09846503
96PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06697026
97PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06406766
98GATA1_22025678_ChIP-Seq_K562_Human1.05957624
99GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05033915
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03065445

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.03250152
2MP0003111_abnormal_nucleus_morphology3.11324680
3MP0010094_abnormal_chromosome_stability2.99052922
4MP0009278_abnormal_bone_marrow2.75304524
5MP0003436_decreased_susceptibility_to2.69028743
6MP0001835_abnormal_antigen_presentation2.50091175
7MP0003693_abnormal_embryo_hatching2.49092046
8MP0008058_abnormal_DNA_repair2.46316287
9MP0003077_abnormal_cell_cycle2.36612318
10MP0004808_abnormal_hematopoietic_stem2.28227561
11MP0005464_abnormal_platelet_physiology2.27121972
12MP0003763_abnormal_thymus_physiology2.25823557
13MP0000685_abnormal_immune_system2.21393846
14MP0003724_increased_susceptibility_to2.20333456
15MP0005397_hematopoietic_system_phenotyp2.17011296
16MP0001545_abnormal_hematopoietic_system2.17011296
17MP0002398_abnormal_bone_marrow2.16049962
18MP0001800_abnormal_humoral_immune2.11272456
19MP0002166_altered_tumor_susceptibility2.07418806
20MP0005000_abnormal_immune_tolerance2.03597233
21MP0008007_abnormal_cellular_replicative2.03589438
22MP0008057_abnormal_DNA_replication2.03174523
23MP0003806_abnormal_nucleotide_metabolis2.01001466
24MP0004957_abnormal_blastocyst_morpholog1.92553884
25MP0000689_abnormal_spleen_morphology1.84996710
26MP0002722_abnormal_immune_system1.83813063
27MP0002452_abnormal_antigen_presenting1.82697413
28MP0005076_abnormal_cell_differentiation1.81816589
29MP0000703_abnormal_thymus_morphology1.79260178
30MP0000465_gastrointestinal_hemorrhage1.77383993
31MP0001819_abnormal_immune_cell1.76908192
32MP0002420_abnormal_adaptive_immunity1.76457173
33MP0002723_abnormal_immune_serum1.75562015
34MP0002429_abnormal_blood_cell1.68241605
35MP0003786_premature_aging1.67936611
36MP0000716_abnormal_immune_system1.67165470
37MP0002019_abnormal_tumor_incidence1.67124106
38MP0008995_early_reproductive_senescence1.60258551
39MP0002009_preneoplasia1.58872956
40MP0008932_abnormal_embryonic_tissue1.49483655
41MP0009333_abnormal_splenocyte_physiolog1.49125897
42MP0005025_abnormal_response_to1.44732607
43MP0002419_abnormal_innate_immunity1.43477571
44MP0003303_peritoneal_inflammation1.42948846
45MP0002138_abnormal_hepatobiliary_system1.42130843
46MP0004381_abnormal_hair_follicle1.38853949
47MP0005451_abnormal_body_composition1.38335260
48MP0002006_tumorigenesis1.38312037
49MP0001661_extended_life_span1.36462114
50MP0003656_abnormal_erythrocyte_physiolo1.35816492
51MP0000372_irregular_coat_pigmentation1.34892120
52MP0006036_abnormal_mitochondrial_physio1.32586652
53MP0000313_abnormal_cell_death1.32219165
54MP0005058_abnormal_lysosome_morphology1.30577175
55MP0005671_abnormal_response_to1.30347494
56MP0000490_abnormal_crypts_of1.28851158
57MP0000015_abnormal_ear_pigmentation1.28174377
58MP0005387_immune_system_phenotype1.28111626
59MP0001790_abnormal_immune_system1.28111626
60MP0005075_abnormal_melanosome_morpholog1.27409574
61MP0004233_abnormal_muscle_weight1.25484930
62MP0000350_abnormal_cell_proliferation1.25428442
63MP0002148_abnormal_hypersensitivity_rea1.23417230
64MP0008260_abnormal_autophagy1.22524684
65MP0003828_pulmonary_edema1.20884695
66MP0003172_abnormal_lysosome_physiology1.16668872
67MP0002405_respiratory_system_inflammati1.13284247
68MP0005220_abnormal_exocrine_pancreas1.10695368
69MP0004947_skin_inflammation1.09128199
70MP0005501_abnormal_skin_physiology1.05366746
71MP0006035_abnormal_mitochondrial_morpho1.03106296
72MP0001845_abnormal_inflammatory_respons1.02225224
73MP0001919_abnormal_reproductive_system1.00339107
74MP0010155_abnormal_intestine_physiology0.99345845
75MP0002132_abnormal_respiratory_system0.94379158
76MP0005083_abnormal_biliary_tract0.93155287
77MP0004185_abnormal_adipocyte_glucose0.93151159
78MP0005621_abnormal_cell_physiology0.92356984
79MP0002080_prenatal_lethality0.90668739
80MP0001533_abnormal_skeleton_physiology0.89503006
81MP0001853_heart_inflammation0.87568195
82MP0000858_altered_metastatic_potential0.86063789
83MP0009931_abnormal_skin_appearance0.84638115
84MP0009765_abnormal_xenobiotic_induced0.83722401
85MP0000598_abnormal_liver_morphology0.82535090
86MP0005384_cellular_phenotype0.80847437
87MP0001697_abnormal_embryo_size0.80701881
88MP0002086_abnormal_extraembryonic_tissu0.80493284
89MP0009785_altered_susceptibility_to0.77878273
90MP0002928_abnormal_bile_duct0.77035346
91MP0002089_abnormal_postnatal_growth/wei0.76729572
92MP0008961_abnormal_basal_metabolism0.74658630
93MP0000358_abnormal_cell_content/0.74144114
94MP0002098_abnormal_vibrissa_morphology0.73801050
95MP0002796_impaired_skin_barrier0.72706616
96MP0003300_gastrointestinal_ulcer0.71914236
97MP0010307_abnormal_tumor_latency0.71785980
98MP0002877_abnormal_melanocyte_morpholog0.71340357
99MP0001881_abnormal_mammary_gland0.70265303
100MP0009840_abnormal_foam_cell0.69165812

Predicted human phenotypes

RankGene SetZ-score
1Prostate neoplasm (HP:0100787)4.41662924
2Chromsome breakage (HP:0040012)3.91655617
3Hyperacusis (HP:0010780)3.63046001
4Abnormality of lateral ventricle (HP:0030047)3.36525122
5Agammaglobulinemia (HP:0004432)3.36114989
6Squamous cell carcinoma (HP:0002860)3.32028448
7IgM deficiency (HP:0002850)3.29149611
8Abnormality of the prostate (HP:0008775)3.28817132
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.22546677
10Cellulitis (HP:0100658)3.13785497
11Abnormality of T cell physiology (HP:0011840)3.13419994
12Microvesicular hepatic steatosis (HP:0001414)3.06852031
13Petechiae (HP:0000967)2.99006332
14Prolonged bleeding time (HP:0003010)2.87966399
15Recurrent viral infections (HP:0004429)2.84780160
16IgA deficiency (HP:0002720)2.72397815
17Elfin facies (HP:0004428)2.68918257
18Overriding aorta (HP:0002623)2.68814255
19Abnormal gallbladder physiology (HP:0012438)2.66944654
20Cholecystitis (HP:0001082)2.66944654
21Gastrointestinal stroma tumor (HP:0100723)2.64938330
22Abnormality of B cell number (HP:0010975)2.64128755
23Anteriorly placed anus (HP:0001545)2.62525311
24B lymphocytopenia (HP:0010976)2.61164305
25Acute lymphatic leukemia (HP:0006721)2.58956703
26Dyschromatopsia (HP:0007641)2.55603656
27Progressive muscle weakness (HP:0003323)2.52536448
28Flat cornea (HP:0007720)2.49605687
29Poikiloderma (HP:0001029)2.47761064
30Meningitis (HP:0001287)2.46139861
31Recurrent bacterial skin infections (HP:0005406)2.44870854
32Abnormality of the carotid arteries (HP:0005344)2.42165466
33Myelodysplasia (HP:0002863)2.38787283
34Insomnia (HP:0100785)2.34215136
35IgG deficiency (HP:0004315)2.33243691
36Abnormality of T cells (HP:0002843)2.31985407
37Granulocytopenia (HP:0001913)2.30985948
38Obstructive lung disease (HP:0006536)2.30781475
39Chronic obstructive pulmonary disease (HP:0006510)2.30781475
40Elevated erythrocyte sedimentation rate (HP:0003565)2.28960561
41Neutropenia (HP:0001875)2.28344182
42Autoimmune hemolytic anemia (HP:0001890)2.28190148
43Panhypogammaglobulinemia (HP:0003139)2.25672887
44Aplastic anemia (HP:0001915)2.25649948
45Lymphopenia (HP:0001888)2.25261611
46Basal cell carcinoma (HP:0002671)2.24434806
47Renal duplication (HP:0000075)2.23536269
48Lymphoma (HP:0002665)2.23319178
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.22781708
50Urticaria (HP:0001025)2.21724687
51Recurrent abscess formation (HP:0002722)2.20986626
52Recurrent sinusitis (HP:0011108)2.15861333
53Leukopenia (HP:0001882)2.14807604
54Reticulocytosis (HP:0001923)2.14428066
55Eczematoid dermatitis (HP:0000976)2.14307275
56Abnormality of male internal genitalia (HP:0000022)2.14025088
57Recurrent fungal infections (HP:0002841)2.13822045
58Bone marrow hypocellularity (HP:0005528)2.13726424
59Abnormal delayed hypersensitivity skin test (HP:0002963)2.12610244
60Hypoplasia of the capital femoral epiphysis (HP:0003090)2.10852422
61Ragged-red muscle fibers (HP:0003200)2.10285258
62Abnormality of cells of the lymphoid lineage (HP:0012140)2.09928713
63Abnormality of the preputium (HP:0100587)2.08597889
64Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.08090260
65Increased IgE level (HP:0003212)2.06148351
66Cutaneous melanoma (HP:0012056)2.05728703
67Colitis (HP:0002583)2.04105110
68Verrucae (HP:0200043)2.03732544
69Papilloma (HP:0012740)2.03732544
70Epistaxis (HP:0000421)2.01781568
71Absent thumb (HP:0009777)2.00817590
72Mediastinal lymphadenopathy (HP:0100721)2.00673200
73Large eyes (HP:0001090)2.00014787
74Abnormality of cochlea (HP:0000375)1.99565579
75Micronodular cirrhosis (HP:0001413)1.98605248
76Renovascular hypertension (HP:0100817)1.97468293
77Polygenic inheritance (HP:0010982)1.95588511
78Abnormal enzyme/coenzyme activity (HP:0012379)1.95556185
79Hypertensive crisis (HP:0100735)1.94185958
80Long palpebral fissure (HP:0000637)1.92851412
81Hepatocellular necrosis (HP:0001404)1.92777979
82Rough bone trabeculation (HP:0100670)1.91954656
83Abnormality of the fingertips (HP:0001211)1.90402455
84Abnormality of chromosome stability (HP:0003220)1.90284186
85Aplasia/Hypoplasia of the thymus (HP:0010515)1.88373896
86Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88036212
87Dicarboxylic aciduria (HP:0003215)1.88036212
88Entropion (HP:0000621)1.87406549
89Birth length less than 3rd percentile (HP:0003561)1.86158012
90Osteomyelitis (HP:0002754)1.85321798
91Vasculitis (HP:0002633)1.84298949
92Progressive microcephaly (HP:0000253)1.82797022
93Abnormality of macrophages (HP:0004311)1.82583742
94Septate vagina (HP:0001153)1.82535084
95Aplasia/Hypoplasia of the uvula (HP:0010293)1.80476201
96Abnormality of reticulocytes (HP:0004312)1.79675558
97Prominent nose (HP:0000448)1.79105962
98Abnormality of the heme biosynthetic pathway (HP:0010472)1.78303077
99Increased muscle lipid content (HP:0009058)1.77515238
100Premature graying of hair (HP:0002216)1.75694853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.63003011
2TLK14.14357585
3VRK13.01329482
4CDK122.82749741
5CDK82.78541665
6MAP4K12.38246138
7NME22.27270960
8SMG12.18431826
9ERN12.12800129
10PLK42.09377656
11VRK22.02298722
12RPS6KB21.97101334
13TESK21.94729227
14MAP2K21.86439473
15TRIB31.79039999
16GRK61.77813963
17SCYL21.76892406
18MAP3K141.74397794
19PIM21.72354278
20SIK31.67971395
21MST41.65094254
22RIPK41.63539256
23SIK11.58028772
24BUB11.56981437
25IRAK41.52421384
26ICK1.46847963
27RPS6KA51.44145605
28TBK11.43592394
29EIF2AK11.40067519
30CCNB11.21767806
31NUAK11.20605285
32BTK1.17791869
33STK161.17333257
34MAP2K31.14944045
35IKBKB1.14386647
36AURKA1.14327050
37TAOK31.12994089
38CDK91.12426705
39STK41.11821832
40BCKDK1.11441482
41PIM11.09792470
42MAPK111.09431633
43IKBKE1.09026310
44CHEK21.06066002
45TNK21.04043503
46TTK0.95817529
47SYK0.95311817
48ATR0.94444190
49EEF2K0.92814753
50IRAK30.92562107
51CSF1R0.92460301
52KIT0.90980185
53CDC70.89320922
54DYRK30.87708574
55NME10.84109163
56DAPK30.83703894
57PRPF4B0.80969070
58CDK70.80458584
59MARK30.80425993
60MAPK150.77295295
61PKN20.76435085
62AURKB0.73816946
63RAF10.71387358
64MAP2K10.69380664
65HIPK20.66602284
66FLT30.62167772
67EIF2AK20.60947363
68MAP3K110.60575147
69MAP3K80.59835806
70MAPKAPK30.57252122
71TEC0.56774837
72SRPK10.55548819
73IRAK20.53753271
74CHUK0.53487843
75HCK0.52996321
76LRRK20.52434094
77CDK40.52191546
78TAOK20.52072157
79AKT20.49150425
80LYN0.47639583
81BRD40.47104533
82MAPK120.45778720
83PBK0.45493729
84RPS6KA40.45417029
85TAF10.44480666
86MAP3K10.42897763
87NEK10.42010742
88MTOR0.40561693
89ZAP700.40260599
90JAK30.40258527
91MATK0.38904682
92CHEK10.38614266
93EPHA20.37851416
94BLK0.36649635
95EIF2AK30.36351172
96ITK0.35213162
97RPS6KA10.33329047
98PLK10.32612400
99MAPKAPK20.32309336
100RPS6KC10.32169901

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053226.01406948
2Alcoholism_Homo sapiens_hsa050343.87941628
3DNA replication_Homo sapiens_hsa030303.78599410
4Mismatch repair_Homo sapiens_hsa034302.91503127
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.46558220
6Nucleotide excision repair_Homo sapiens_hsa034202.28994534
7Base excision repair_Homo sapiens_hsa034102.26710284
8Viral carcinogenesis_Homo sapiens_hsa052032.24776174
9Proteasome_Homo sapiens_hsa030502.19103510
10Primary immunodeficiency_Homo sapiens_hsa053402.04540277
11Homologous recombination_Homo sapiens_hsa034402.00091511
12Asthma_Homo sapiens_hsa053101.80010432
13Non-homologous end-joining_Homo sapiens_hsa034501.77111441
14Allograft rejection_Homo sapiens_hsa053301.72336955
15Fanconi anemia pathway_Homo sapiens_hsa034601.70965398
16Leishmaniasis_Homo sapiens_hsa051401.65410772
17B cell receptor signaling pathway_Homo sapiens_hsa046621.63691147
18Spliceosome_Homo sapiens_hsa030401.56786813
19Autoimmune thyroid disease_Homo sapiens_hsa053201.55041871
20Transcriptional misregulation in cancer_Homo sapiens_hsa052021.51116445
21Cell cycle_Homo sapiens_hsa041101.42227059
22Herpes simplex infection_Homo sapiens_hsa051681.40592009
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37671898
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.36748772
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35693083
26Pentose phosphate pathway_Homo sapiens_hsa000301.35645539
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35345198
28Graft-versus-host disease_Homo sapiens_hsa053321.32713122
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29125485
30Pyrimidine metabolism_Homo sapiens_hsa002401.26712927
31RNA polymerase_Homo sapiens_hsa030201.24776945
32Epstein-Barr virus infection_Homo sapiens_hsa051691.23835849
33One carbon pool by folate_Homo sapiens_hsa006701.21236538
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17456069
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.12388714
36Acute myeloid leukemia_Homo sapiens_hsa052211.11033236
37Antigen processing and presentation_Homo sapiens_hsa046121.05367175
38Sulfur relay system_Homo sapiens_hsa041221.05206770
39Type I diabetes mellitus_Homo sapiens_hsa049400.99915841
40Fatty acid elongation_Homo sapiens_hsa000620.95664108
41RNA transport_Homo sapiens_hsa030130.94495117
42RNA degradation_Homo sapiens_hsa030180.91925576
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90602377
44Biosynthesis of amino acids_Homo sapiens_hsa012300.90318139
45p53 signaling pathway_Homo sapiens_hsa041150.89759052
46Viral myocarditis_Homo sapiens_hsa054160.88474532
47Fructose and mannose metabolism_Homo sapiens_hsa000510.84568066
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82981954
49Apoptosis_Homo sapiens_hsa042100.82560788
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80687138
51Carbon metabolism_Homo sapiens_hsa012000.79868735
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79483573
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79471153
54Hepatitis B_Homo sapiens_hsa051610.77293263
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73406320
56N-Glycan biosynthesis_Homo sapiens_hsa005100.73077015
57Thyroid cancer_Homo sapiens_hsa052160.72409532
58Other glycan degradation_Homo sapiens_hsa005110.71994201
59HTLV-I infection_Homo sapiens_hsa051660.71684432
60Measles_Homo sapiens_hsa051620.70478293
61Influenza A_Homo sapiens_hsa051640.70432279
62Tuberculosis_Homo sapiens_hsa051520.70325432
63Chronic myeloid leukemia_Homo sapiens_hsa052200.66709921
64Osteoclast differentiation_Homo sapiens_hsa043800.64550254
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63854633
66Non-small cell lung cancer_Homo sapiens_hsa052230.63818570
67Legionellosis_Homo sapiens_hsa051340.63052365
68Ribosome_Homo sapiens_hsa030100.62578382
69Toxoplasmosis_Homo sapiens_hsa051450.61412153
70Hematopoietic cell lineage_Homo sapiens_hsa046400.60295919
71mRNA surveillance pathway_Homo sapiens_hsa030150.57724026
72Purine metabolism_Homo sapiens_hsa002300.55856443
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55391810
74Basal transcription factors_Homo sapiens_hsa030220.54294847
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52871410
76Staphylococcus aureus infection_Homo sapiens_hsa051500.50764775
77Folate biosynthesis_Homo sapiens_hsa007900.50729849
78Bladder cancer_Homo sapiens_hsa052190.49674850
79T cell receptor signaling pathway_Homo sapiens_hsa046600.48959991
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48201285
81Hepatitis C_Homo sapiens_hsa051600.47941942
82Galactose metabolism_Homo sapiens_hsa000520.44307105
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43529914
84Platelet activation_Homo sapiens_hsa046110.40779240
85Pancreatic cancer_Homo sapiens_hsa052120.40429833
86Shigellosis_Homo sapiens_hsa051310.40031429
87Fatty acid metabolism_Homo sapiens_hsa012120.39860104
88Parkinsons disease_Homo sapiens_hsa050120.39179073
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37702433
90TNF signaling pathway_Homo sapiens_hsa046680.36976411
91Rheumatoid arthritis_Homo sapiens_hsa053230.35603530
92Small cell lung cancer_Homo sapiens_hsa052220.35290935
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31928114
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31829094
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.31689950
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.30985578
97mTOR signaling pathway_Homo sapiens_hsa041500.29738217
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28126026
99Pyruvate metabolism_Homo sapiens_hsa006200.27447593
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26312793

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »