ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of B cell apoptotic process (GO:0002903)	6.17353308
2	immunoglobulin mediated immune response (GO:0016064)	5.09231672
3	DNA deamination (GO:0045006)	4.80003095
4	regulation of B cell apoptotic process (GO:0002902)	4.60753843
5	B cell mediated immunity (GO:0019724)	4.50993614
6	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	4.20346226
7	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.03583501
8	purine deoxyribonucleotide catabolic process (GO:0009155)	4.03404815
9	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.00529374
10	purine nucleotide salvage (GO:0032261)	3.93128984
11	pseudouridine synthesis (GO:0001522)	3.89738239
12	deoxyribonucleotide catabolic process (GO:0009264)	3.82886322
13	interferon-gamma secretion (GO:0072643)	3.79331914
14	fucose catabolic process (GO:0019317)	3.72672889
15	L-fucose metabolic process (GO:0042354)	3.72672889
16	L-fucose catabolic process (GO:0042355)	3.72672889
17	deoxyribose phosphate catabolic process (GO:0046386)	3.65526083
18	thrombin receptor signaling pathway (GO:0070493)	3.64736907
19	telomere maintenance via semi-conservative replication (GO:0032201)	3.47767124
20	nucleotide salvage (GO:0043173)	3.43617776
21	rRNA modification (GO:0000154)	3.39977476
22	positive regulation of antigen processing and presentation (GO:0002579)	3.37685563
23	chaperone mediated protein folding requiring cofactor (GO:0051085)	3.23245380
24	histone H2A acetylation (GO:0043968)	3.20601764
25	pyrimidine nucleotide catabolic process (GO:0006244)	3.10007463
26	telomere maintenance via telomere lengthening (GO:0010833)	3.08144570
27	regulation of antigen processing and presentation (GO:0002577)	3.05634079
28	DNA strand elongation involved in DNA replication (GO:0006271)	3.03274428
29	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.98962348
30	purine deoxyribonucleotide metabolic process (GO:0009151)	2.98469709
31	mature B cell differentiation involved in immune response (GO:0002313)	2.96667761
32	DNA replication checkpoint (GO:0000076)	2.96102829
33	DNA strand elongation (GO:0022616)	2.94518496
34	fusion of sperm to egg plasma membrane (GO:0007342)	2.93772351
35	positive thymic T cell selection (GO:0045059)	2.93566820
36	2-deoxyribonucleotide metabolic process (GO:0009394)	2.93500183
37	dosage compensation (GO:0007549)	2.92028979
38	interferon-gamma-mediated signaling pathway (GO:0060333)	2.91169849
39	telomere maintenance via recombination (GO:0000722)	2.88860478
40	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.87383843
41	negative regulation of thymocyte apoptotic process (GO:0070244)	2.85132641
42	antigen processing and presentation of endogenous antigen (GO:0019883)	2.83727754
43	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.82580907
44	autophagic vacuole fusion (GO:0000046)	2.81491547
45	rRNA methylation (GO:0031167)	2.81149986
46	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.80764149
47	DNA replication-dependent nucleosome organization (GO:0034723)	2.79426323
48	DNA replication-dependent nucleosome assembly (GO:0006335)	2.79426323
49	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.78337238
50	deoxyribose phosphate metabolic process (GO:0019692)	2.77328695
51	regulation of dendritic cell antigen processing and presentation (GO:0002604)	2.74411396
52	protein neddylation (GO:0045116)	2.74005850
53	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.71507388
54	negative thymic T cell selection (GO:0045060)	2.71015823
55	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.69543757
56	tryptophan metabolic process (GO:0006568)	2.67335958
57	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	2.66787030
58	negative T cell selection (GO:0043383)	2.65779130
59	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	2.64316622
60	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.63571216
61	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.63338882
62	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.62957131
63	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.62012803
64	inositol phosphate dephosphorylation (GO:0046855)	2.62012803
65	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.61838514
66	base-excision repair, AP site formation (GO:0006285)	2.60381938
67	negative regulation of mRNA processing (GO:0050686)	2.60288381
68	proteasome assembly (GO:0043248)	2.59072972
69	deoxyribonucleotide metabolic process (GO:0009262)	2.58789744
70	purine-containing compound salvage (GO:0043101)	2.57801489
71	mitotic recombination (GO:0006312)	2.56803358
72	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.56729409
73	tRNA modification (GO:0006400)	2.56320719
74	negative regulation of ligase activity (GO:0051352)	2.54259524
75	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.54259524
76	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.52698405
77	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.52532532
78	cullin deneddylation (GO:0010388)	2.52375890
79	tRNA processing (GO:0008033)	2.52206055
80	glutathione biosynthetic process (GO:0006750)	2.51688533
81	platelet dense granule organization (GO:0060155)	2.50444461
82	tyrosine phosphorylation of STAT protein (GO:0007260)	2.49710454
83	peptidyl-arginine omega-N-methylation (GO:0035247)	2.48704225
84	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.48171857
85	folic acid-containing compound biosynthetic process (GO:0009396)	2.43323363
86	replication fork processing (GO:0031297)	2.41929392
87	mannosylation (GO:0097502)	2.41284500
88	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.41156224
89	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.41156224
90	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.41138905
91	innate immune response in mucosa (GO:0002227)	2.40708531
92	fucose metabolic process (GO:0006004)	2.40365016
93	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.40202515
94	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.40202515
95	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.40202515
96	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	2.39978156
97	organelle membrane fusion (GO:0090174)	2.39321709
98	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.38672802
99	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.38064923
100	regulation of thymocyte apoptotic process (GO:0070243)	2.37886326

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	3.67809172
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.17107283
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.09584692
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.79639709
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.76101919
6	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.58051383
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.56650773
8	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.41694624
9	MYC_22102868_ChIP-Seq_BL_Human	2.32141212
10	CIITA_25753668_ChIP-Seq_RAJI_Human	2.28594532
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.25192407
12	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.24690885
13	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.22249211
14	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	2.18679897
15	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.14562909
16	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.10411134
17	VDR_21846776_ChIP-Seq_THP-1_Human	2.08449123
18	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.08080057
19	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.06284042
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.00813447
21	FOXP3_21729870_ChIP-Seq_TREG_Human	2.00295655
22	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.98122182
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.98080558
24	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.97732687
25	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.97520062
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.91014353
27	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.90103310
28	VDR_23849224_ChIP-Seq_CD4+_Human	1.89646294
29	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.86823201
30	XRN2_22483619_ChIP-Seq_HELA_Human	1.84550416
31	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.83461195
32	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.81265905
33	DCP1A_22483619_ChIP-Seq_HELA_Human	1.79894102
34	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.76635862
35	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.74113887
36	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.70168735
37	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.69391668
38	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.69334963
39	GABP_19822575_ChIP-Seq_HepG2_Human	1.68163354
40	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.67656333
41	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.66047503
42	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.65500603
43	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.65205210
44	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.62780005
45	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.60654322
46	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.58129901
47	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.55996643
48	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.55439014
49	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.54126908
50	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.52114177
51	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.51630398
52	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.51218769
53	MAF_26560356_Chip-Seq_TH1_Human	1.50062089
54	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.49392009
55	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.47905594
56	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.47873698
57	VDR_24763502_ChIP-Seq_THP-1_Human	1.47339762
58	KDM5A_27292631_Chip-Seq_BREAST_Human	1.45717874
59	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.45241094
60	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.44683158
61	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.43381748
62	SPI1_23547873_ChIP-Seq_NB4_Human	1.43193221
63	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.42456885
64	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.41072857
65	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.38751643
66	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.37949841
67	MAF_26560356_Chip-Seq_TH2_Human	1.36045799
68	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.34796967
69	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.34029425
70	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.33584416
71	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.32764999
72	UTX_26944678_Chip-Seq_JUKART_Human	1.32316848
73	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.31873833
74	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.30183333
75	P68_20966046_ChIP-Seq_HELA_Human	1.28668329
76	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.28045641
77	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.28000097
78	BCOR_27268052_Chip-Seq_Bcells_Human	1.22414517
79	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.22367123
80	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.21518886
81	MYB_26560356_Chip-Seq_TH2_Human	1.21179928
82	TTF2_22483619_ChIP-Seq_HELA_Human	1.21156819
83	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.19368648
84	BCL6_27268052_Chip-Seq_Bcells_Human	1.19198710
85	SCL_19346495_ChIP-Seq_HPC-7_Human	1.19061657
86	E2F1_20622854_ChIP-Seq_HELA_Human	1.18683758
87	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.16182699
88	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.13066553
89	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.12324840
90	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.11509746
91	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.10812930
92	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.10362695
93	TFEB_21752829_ChIP-Seq_HELA_Human	1.10179942
94	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.08940225
95	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.08774321
96	MYB_26560356_Chip-Seq_TH1_Human	1.08537114
97	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.07613265
98	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.06761538
99	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.06728605
100	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.06694612

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	3.99471109
2	MP0003111_abnormal_nucleus_morphology	3.41805233
3	MP0003693_abnormal_embryo_hatching	3.29243584
4	MP0009697_abnormal_copulation	3.12695783
5	MP0010094_abnormal_chromosome_stability	2.94157814
6	MP0009278_abnormal_bone_marrow	2.87600055
7	MP0005464_abnormal_platelet_physiology	2.75924349
8	MP0002396_abnormal_hematopoietic_system	2.75000181
9	MP0003806_abnormal_nucleotide_metabolis	2.64009376
10	MP0002138_abnormal_hepatobiliary_system	2.57097838
11	MP0005075_abnormal_melanosome_morpholog	2.35873562
12	MP0005397_hematopoietic_system_phenotyp	2.26102500
13	MP0001545_abnormal_hematopoietic_system	2.26102500
14	MP0000685_abnormal_immune_system	2.21477987
15	MP0005645_abnormal_hypothalamus_physiol	2.21460157
16	MP0002166_altered_tumor_susceptibility	2.20496248
17	MP0000465_gastrointestinal_hemorrhage	2.17485135
18	MP0003077_abnormal_cell_cycle	2.16032091
19	MP0005000_abnormal_immune_tolerance	2.05731273
20	MP0002398_abnormal_bone_marrow	2.03321723
21	MP0008058_abnormal_DNA_repair	2.01160840
22	MP0001800_abnormal_humoral_immune	1.89830653
23	MP0004957_abnormal_blastocyst_morpholog	1.88041975
24	MP0002019_abnormal_tumor_incidence	1.85674929
25	MP0003303_peritoneal_inflammation	1.80677098
26	MP0002006_tumorigenesis	1.80276531
27	MP0002452_abnormal_antigen_presenting	1.77534825
28	MP0005671_abnormal_response_to	1.76005287
29	MP0002148_abnormal_hypersensitivity_rea	1.75510187
30	MP0004808_abnormal_hematopoietic_stem	1.71444906
31	MP0006036_abnormal_mitochondrial_physio	1.70324854
32	MP0002420_abnormal_adaptive_immunity	1.70216512
33	MP0003724_increased_susceptibility_to	1.69661701
34	MP0003436_decreased_susceptibility_to	1.68582018
35	MP0001819_abnormal_immune_cell	1.67802919
36	MP0002723_abnormal_immune_serum	1.66408884
37	MP0000689_abnormal_spleen_morphology	1.64465716
38	MP0002429_abnormal_blood_cell	1.61872966
39	MP0008007_abnormal_cellular_replicative	1.60036360
40	MP0002722_abnormal_immune_system	1.59357880
41	MP0000716_abnormal_immune_system	1.59201436
42	MP0001790_abnormal_immune_system	1.56948402
43	MP0005387_immune_system_phenotype	1.56948402
44	MP0005025_abnormal_response_to	1.54183991
45	MP0005058_abnormal_lysosome_morphology	1.53144453
46	MP0003718_maternal_effect	1.52541131
47	MP0009785_altered_susceptibility_to	1.49654452
48	MP0008961_abnormal_basal_metabolism	1.44683847
49	MP0009333_abnormal_splenocyte_physiolog	1.41775093
50	MP0008872_abnormal_physiological_respon	1.38885644
51	MP0003763_abnormal_thymus_physiology	1.36750027
52	MP0002405_respiratory_system_inflammati	1.35982324
53	MP0001873_stomach_inflammation	1.35838282
54	MP0002419_abnormal_innate_immunity	1.33761061
55	MP0008995_early_reproductive_senescence	1.32930933
56	MP0000703_abnormal_thymus_morphology	1.32349052
57	MP0000490_abnormal_crypts_of	1.29108660
58	MP0008932_abnormal_embryonic_tissue	1.26931813
59	MP0003252_abnormal_bile_duct	1.24729887
60	MP0000313_abnormal_cell_death	1.22389447
61	MP0003786_premature_aging	1.20546683
62	MP0005220_abnormal_exocrine_pancreas	1.19917861
63	MP0010155_abnormal_intestine_physiology	1.17692918
64	MP0010307_abnormal_tumor_latency	1.15594862
65	MP0001845_abnormal_inflammatory_respons	1.10701423
66	MP0005084_abnormal_gallbladder_morpholo	1.05951969
67	MP0003172_abnormal_lysosome_physiology	1.05483426
68	MP0004381_abnormal_hair_follicle	1.00262552
69	MP0008057_abnormal_DNA_replication	0.98952333
70	MP0009764_decreased_sensitivity_to	0.98863590
71	MP0005451_abnormal_body_composition	0.97715982
72	MP0001853_heart_inflammation	0.97361286
73	MP0006035_abnormal_mitochondrial_morpho	0.96196728
74	MP0008875_abnormal_xenobiotic_pharmacok	0.94192996
75	MP0005410_abnormal_fertilization	0.92435671
76	MP0000350_abnormal_cell_proliferation	0.88229789
77	MP0000358_abnormal_cell_content/	0.86465853
78	MP0002089_abnormal_postnatal_growth/wei	0.84446907
79	MP0005501_abnormal_skin_physiology	0.80920269
80	MP0002332_abnormal_exercise_endurance	0.78053835
81	MP0008469_abnormal_protein_level	0.77729026
82	MP0002132_abnormal_respiratory_system	0.76594344
83	MP0008873_increased_physiological_sensi	0.76046344
84	MP0000858_altered_metastatic_potential	0.75887502
85	MP0003866_abnormal_defecation	0.75700586
86	MP0001764_abnormal_homeostasis	0.73064890
87	MP0000015_abnormal_ear_pigmentation	0.69261299
88	MP0002080_prenatal_lethality	0.67062411
89	MP0004947_skin_inflammation	0.66157022
90	MP0001730_embryonic_growth_arrest	0.65191155
91	MP0001663_abnormal_digestive_system	0.64395163
92	MP0001533_abnormal_skeleton_physiology	0.63696717
93	MP0009763_increased_sensitivity_to	0.63430427
94	MP0004233_abnormal_muscle_weight	0.62601906
95	MP0005266_abnormal_metabolism	0.62319447
96	MP0005621_abnormal_cell_physiology	0.62095319
97	MP0003191_abnormal_cellular_cholesterol	0.61310653
98	MP0003186_abnormal_redox_activity	0.60632906
99	MP0005384_cellular_phenotype	0.59472926
100	MP0009765_abnormal_xenobiotic_induced	0.58934685

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prostate neoplasm (HP:0100787)	4.04326907
2	Abnormality of B cell number (HP:0010975)	3.72467864
3	Petechiae (HP:0000967)	3.69139846
4	Abnormality of the prostate (HP:0008775)	3.52095344
5	B lymphocytopenia (HP:0010976)	3.48671321
6	Hypomagnesemia (HP:0002917)	3.45081038
7	Agammaglobulinemia (HP:0004432)	3.37026627
8	Aplastic anemia (HP:0001915)	3.33467281
9	Microvesicular hepatic steatosis (HP:0001414)	3.29657580
10	Abnormal number of erythroid precursors (HP:0012131)	3.23488418
11	Elevated erythrocyte sedimentation rate (HP:0003565)	3.19466382
12	Hypoplasia of the capital femoral epiphysis (HP:0003090)	3.17503470
13	Panhypogammaglobulinemia (HP:0003139)	3.17501597
14	Hyperacusis (HP:0010780)	3.08407921
15	Abnormality of lateral ventricle (HP:0030047)	2.98872829
16	Prolonged bleeding time (HP:0003010)	2.98012837
17	Abnormality of magnesium homeostasis (HP:0004921)	2.94483434
18	Recurrent fungal infections (HP:0002841)	2.87106174
19	Overriding aorta (HP:0002623)	2.75607598
20	Elfin facies (HP:0004428)	2.75466429
21	Cellulitis (HP:0100658)	2.64170166
22	Increased serum lactate (HP:0002151)	2.63162385
23	Myelodysplasia (HP:0002863)	2.62875947
24	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.62577083
25	Progressive muscle weakness (HP:0003323)	2.61663484
26	Chronic obstructive pulmonary disease (HP:0006510)	2.61558932
27	Obstructive lung disease (HP:0006536)	2.61558932
28	Epistaxis (HP:0000421)	2.61201644
29	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.56303202
30	Mesangial abnormality (HP:0001966)	2.53398484
31	Hypertensive crisis (HP:0100735)	2.52090618
32	Acute lymphatic leukemia (HP:0006721)	2.50625839
33	Dyschromatopsia (HP:0007641)	2.50154856
34	Increased intramyocellular lipid droplets (HP:0012240)	2.48954187
35	Absent thumb (HP:0009777)	2.48951308
36	Dicarboxylic aciduria (HP:0003215)	2.48633380
37	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.48633380
38	Abnormality of cells of the erythroid lineage (HP:0012130)	2.47982945
39	Abnormal mitochondria in muscle tissue (HP:0008316)	2.43973247
40	Hepatocellular necrosis (HP:0001404)	2.43655406
41	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.41499356
42	Squamous cell carcinoma (HP:0002860)	2.40932348
43	Abnormality of the carotid arteries (HP:0005344)	2.40545105
44	Meningitis (HP:0001287)	2.38330397
45	Recurrent viral infections (HP:0004429)	2.36337808
46	Hepatic necrosis (HP:0002605)	2.34469049
47	Absent epiphyses (HP:0010577)	2.33369150
48	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.33369150
49	Chronic mucocutaneous candidiasis (HP:0002728)	2.33154607
50	Recurrent cutaneous fungal infections (HP:0011370)	2.33154607
51	Abnormality of T cell physiology (HP:0011840)	2.30463905
52	Testicular atrophy (HP:0000029)	2.30251691
53	Increased muscle lipid content (HP:0009058)	2.29758405
54	Abnormality of male internal genitalia (HP:0000022)	2.29745781
55	Autoimmune thrombocytopenia (HP:0001973)	2.27175754
56	Autoimmune hemolytic anemia (HP:0001890)	2.26806680
57	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.23951462
58	Mediastinal lymphadenopathy (HP:0100721)	2.19933205
59	Increased serum ferritin (HP:0003281)	2.17721392
60	Birth length less than 3rd percentile (HP:0003561)	2.17080521
61	Acute necrotizing encephalopathy (HP:0006965)	2.16949927
62	Delayed CNS myelination (HP:0002188)	2.15501047
63	Severe combined immunodeficiency (HP:0004430)	2.15224943
64	Abnormality of the preputium (HP:0100587)	2.13526887
65	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.12020585
66	Flat cornea (HP:0007720)	2.06864328
67	Granulocytopenia (HP:0001913)	2.06119476
68	Prominent nose (HP:0000448)	2.05475754
69	Abnormality of T cells (HP:0002843)	2.05256987
70	Mitochondrial inheritance (HP:0001427)	2.04857999
71	Progressive microcephaly (HP:0000253)	2.01442490
72	Bone marrow hypocellularity (HP:0005528)	2.00946647
73	Pulmonary fibrosis (HP:0002206)	1.97948457
74	Lactic acidosis (HP:0003128)	1.96883621
75	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.96227136
76	Renovascular hypertension (HP:0100817)	1.94225925
77	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.93489704
78	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.93489704
79	Increased CSF lactate (HP:0002490)	1.93458136
80	Poor head control (HP:0002421)	1.93079227
81	Large eyes (HP:0001090)	1.92541361
82	Attenuation of retinal blood vessels (HP:0007843)	1.91982266
83	Abolished electroretinogram (ERG) (HP:0000550)	1.91089637
84	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.90476746
85	Insomnia (HP:0100785)	1.89180200
86	Hypercalciuria (HP:0002150)	1.88273163
87	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.86682150
88	Encephalitis (HP:0002383)	1.86081296
89	Increased IgE level (HP:0003212)	1.84020073
90	Type I transferrin isoform profile (HP:0003642)	1.81566476
91	Microretrognathia (HP:0000308)	1.81316752
92	J-shaped sella turcica (HP:0002680)	1.81195663
93	Chromsome breakage (HP:0040012)	1.80109792
94	Combined immunodeficiency (HP:0005387)	1.79111567
95	Abnormality of iron homeostasis (HP:0011031)	1.78861254
96	Chest pain (HP:0100749)	1.78837213
97	Clubbing of toes (HP:0100760)	1.78448909
98	Pancytopenia (HP:0001876)	1.78272275
99	Exercise intolerance (HP:0003546)	1.77962008
100	Renal Fanconi syndrome (HP:0001994)	1.76843773

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	4.92632296
2	TLK1	4.69908458
3	SCYL2	4.17765499
4	ERN1	3.19600023
5	BUB1	2.83722086
6	MAP4K1	2.64854697
7	KIT	2.53010924
8	BCKDK	2.22001120
9	KDR	2.10048403
10	NUAK1	2.09398085
11	MST4	2.08624260
12	TAOK3	2.07473091
13	TESK2	1.95077283
14	CDK12	1.91888935
15	NME2	1.89081573
16	SIK3	1.85064478
17	STK4	1.84150888
18	VRK1	1.80016087
19	VRK2	1.70563831
20	TBK1	1.60492776
21	CDK8	1.59557111
22	CDC7	1.46810222
23	ATR	1.37958264
24	PIM2	1.37577831
25	FLT3	1.37520113
26	MAP4K2	1.36869222
27	IKBKB	1.34524045
28	CSF1R	1.25859985
29	STK16	1.22418565
30	SYK	1.22185415
31	MAP2K3	1.20016829
32	PBK	1.19049508
33	EIF2AK1	1.17050184
34	RPS6KA5	1.16359345
35	MAP3K14	1.15361515
36	IKBKE	1.11700398
37	IRAK4	1.11641981
38	SMG1	1.11590114
39	FER	1.03690362
40	GRK6	1.02445045
41	CDK9	0.96928729
42	AURKA	0.95177690
43	SIK1	0.92657095
44	MAP3K3	0.90336646
45	MAP3K8	0.90334046
46	MAPK11	0.89320109
47	JAK3	0.84534166
48	CDK4	0.83402060
49	CCNB1	0.83365327
50	IRAK3	0.82038915
51	AURKB	0.81320354
52	BTK	0.80038386
53	CHEK2	0.78913371
54	SIK2	0.77129542
55	FES	0.75937577
56	SRPK1	0.74821386
57	MAPKAPK3	0.73691855
58	DYRK3	0.72433442
59	LYN	0.71324129
60	BMX	0.70381193
61	PIM1	0.69745638
62	IRAK2	0.68202623
63	CDK7	0.66891529
64	PLK1	0.66164036
65	RPS6KB2	0.64668819
66	RPS6KA4	0.62638691
67	MAP3K13	0.61756754
68	MAP3K11	0.61485260
69	BLK	0.56037619
70	MARK3	0.55269917
71	DAPK1	0.53140214
72	CHEK1	0.50057207
73	TRIM28	0.49947818
74	STK10	0.48567918
75	PLK4	0.48142753
76	CHUK	0.47708168
77	MAP2K2	0.46491400
78	TNK2	0.46023645
79	TEC	0.45676804
80	TTK	0.43754189
81	PRKCI	0.42149219
82	RIPK4	0.42042681
83	HIPK2	0.41130657
84	EIF2AK3	0.40332332
85	AKT2	0.37768106
86	IRAK1	0.37246623
87	DAPK3	0.34036696
88	BMPR1B	0.32482207
89	ATM	0.32200804
90	PRKCQ	0.31214180
91	MATK	0.30026590
92	MAP3K1	0.29256903
93	EIF2AK2	0.29098383
94	PKN2	0.28614604
95	MAPKAPK2	0.28586275
96	CDK2	0.25266389
97	MAP3K2	0.24866942
98	ARAF	0.24089178
99	DYRK1B	0.23935127
100	PAK1	0.22970814

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	4.27701047
2	Asthma_Homo sapiens_hsa05310	3.77526487
3	Allograft rejection_Homo sapiens_hsa05330	3.47702061
4	DNA replication_Homo sapiens_hsa03030	3.26373031
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.09939233
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.08519928
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.95973768
8	Proteasome_Homo sapiens_hsa03050	2.70295555
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.62845664
10	Mismatch repair_Homo sapiens_hsa03430	2.45588358
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.39280626
12	Alcoholism_Homo sapiens_hsa05034	2.26710305
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.16876604
14	Antigen processing and presentation_Homo sapiens_hsa04612	2.11135692
15	Base excision repair_Homo sapiens_hsa03410	2.04370941
16	Fatty acid elongation_Homo sapiens_hsa00062	1.92598438
17	Leishmaniasis_Homo sapiens_hsa05140	1.91589565
18	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.86600595
19	Primary immunodeficiency_Homo sapiens_hsa05340	1.84193169
20	Viral myocarditis_Homo sapiens_hsa05416	1.83397390
21	RNA polymerase_Homo sapiens_hsa03020	1.78488635
22	Homologous recombination_Homo sapiens_hsa03440	1.70213764
23	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.61154113
24	Herpes simplex infection_Homo sapiens_hsa05168	1.59067811
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.56843495
26	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.56210700
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.54570681
28	Spliceosome_Homo sapiens_hsa03040	1.44888351
29	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.43902987
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.37991033
31	Viral carcinogenesis_Homo sapiens_hsa05203	1.35446314
32	Sulfur relay system_Homo sapiens_hsa04122	1.21087623
33	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.18825730
34	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.16719115
35	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.16634187
36	Non-homologous end-joining_Homo sapiens_hsa03450	1.13985481
37	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.13656204
38	One carbon pool by folate_Homo sapiens_hsa00670	1.13238775
39	Cell cycle_Homo sapiens_hsa04110	1.10821749
40	Rheumatoid arthritis_Homo sapiens_hsa05323	1.03212994
41	Sulfur metabolism_Homo sapiens_hsa00920	1.01650877
42	Pyruvate metabolism_Homo sapiens_hsa00620	1.00591371
43	Purine metabolism_Homo sapiens_hsa00230	0.99540554
44	RNA degradation_Homo sapiens_hsa03018	0.98954200
45	RNA transport_Homo sapiens_hsa03013	0.96579125
46	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.90883376
47	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.88615662
48	Tuberculosis_Homo sapiens_hsa05152	0.88058000
49	Influenza A_Homo sapiens_hsa05164	0.87231166
50	Toxoplasmosis_Homo sapiens_hsa05145	0.83049237
51	Parkinsons disease_Homo sapiens_hsa05012	0.81745386
52	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.79210772
53	HTLV-I infection_Homo sapiens_hsa05166	0.73151059
54	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.69497438
55	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.66303380
56	Ribosome_Homo sapiens_hsa03010	0.61355842
57	Platelet activation_Homo sapiens_hsa04611	0.58002485
58	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.56664047
59	Pentose phosphate pathway_Homo sapiens_hsa00030	0.54974402
60	Oxidative phosphorylation_Homo sapiens_hsa00190	0.53363795
61	Glutathione metabolism_Homo sapiens_hsa00480	0.52728989
62	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.52403041
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.51750265
64	Lysine degradation_Homo sapiens_hsa00310	0.51343382
65	p53 signaling pathway_Homo sapiens_hsa04115	0.50344600
66	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.49767883
67	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.48749921
68	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.45134938
69	Measles_Homo sapiens_hsa05162	0.44277723
70	Legionellosis_Homo sapiens_hsa05134	0.44061911
71	Carbon metabolism_Homo sapiens_hsa01200	0.43823622
72	Basal transcription factors_Homo sapiens_hsa03022	0.40641577
73	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.37452428
74	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.37006030
75	Folate biosynthesis_Homo sapiens_hsa00790	0.36633959
76	Huntingtons disease_Homo sapiens_hsa05016	0.36312569
77	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.35174251
78	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.34932505
79	Phagosome_Homo sapiens_hsa04145	0.33675674
80	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.32970347
81	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.32885245
82	Selenocompound metabolism_Homo sapiens_hsa00450	0.31715573
83	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.31010132
84	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.30865821
85	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.30682126
86	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.28836012
87	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.28272542
88	Apoptosis_Homo sapiens_hsa04210	0.26864333
89	Fatty acid metabolism_Homo sapiens_hsa01212	0.26443396
90	Peroxisome_Homo sapiens_hsa04146	0.25257437
91	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.24159307
92	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.23780376
93	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.22675464
94	Metabolic pathways_Homo sapiens_hsa01100	0.22178890
95	Shigellosis_Homo sapiens_hsa05131	0.21346467
96	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.21165981
97	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.19830263
98	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.19366580
99	Protein export_Homo sapiens_hsa03060	0.18725312
100	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.18718534

HIST2H2BD

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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