HIST2H2BD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of B cell apoptotic process (GO:0002903)6.17353308
2immunoglobulin mediated immune response (GO:0016064)5.09231672
3DNA deamination (GO:0045006)4.80003095
4regulation of B cell apoptotic process (GO:0002902)4.60753843
5B cell mediated immunity (GO:0019724)4.50993614
6positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.20346226
7pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.03583501
8purine deoxyribonucleotide catabolic process (GO:0009155)4.03404815
9deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.00529374
10purine nucleotide salvage (GO:0032261)3.93128984
11pseudouridine synthesis (GO:0001522)3.89738239
12deoxyribonucleotide catabolic process (GO:0009264)3.82886322
13interferon-gamma secretion (GO:0072643)3.79331914
14fucose catabolic process (GO:0019317)3.72672889
15L-fucose metabolic process (GO:0042354)3.72672889
16L-fucose catabolic process (GO:0042355)3.72672889
17deoxyribose phosphate catabolic process (GO:0046386)3.65526083
18thrombin receptor signaling pathway (GO:0070493)3.64736907
19telomere maintenance via semi-conservative replication (GO:0032201)3.47767124
20nucleotide salvage (GO:0043173)3.43617776
21rRNA modification (GO:0000154)3.39977476
22positive regulation of antigen processing and presentation (GO:0002579)3.37685563
23chaperone mediated protein folding requiring cofactor (GO:0051085)3.23245380
24histone H2A acetylation (GO:0043968)3.20601764
25pyrimidine nucleotide catabolic process (GO:0006244)3.10007463
26telomere maintenance via telomere lengthening (GO:0010833)3.08144570
27regulation of antigen processing and presentation (GO:0002577)3.05634079
28DNA strand elongation involved in DNA replication (GO:0006271)3.03274428
29purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.98962348
30purine deoxyribonucleotide metabolic process (GO:0009151)2.98469709
31mature B cell differentiation involved in immune response (GO:0002313)2.96667761
32DNA replication checkpoint (GO:0000076)2.96102829
33DNA strand elongation (GO:0022616)2.94518496
34fusion of sperm to egg plasma membrane (GO:0007342)2.93772351
35positive thymic T cell selection (GO:0045059)2.93566820
362-deoxyribonucleotide metabolic process (GO:0009394)2.93500183
37dosage compensation (GO:0007549)2.92028979
38interferon-gamma-mediated signaling pathway (GO:0060333)2.91169849
39telomere maintenance via recombination (GO:0000722)2.88860478
40pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.87383843
41negative regulation of thymocyte apoptotic process (GO:0070244)2.85132641
42antigen processing and presentation of endogenous antigen (GO:0019883)2.83727754
43negative regulation of lymphocyte apoptotic process (GO:0070229)2.82580907
44autophagic vacuole fusion (GO:0000046)2.81491547
45rRNA methylation (GO:0031167)2.81149986
46negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.80764149
47DNA replication-dependent nucleosome organization (GO:0034723)2.79426323
48DNA replication-dependent nucleosome assembly (GO:0006335)2.79426323
49nucleotide-excision repair, DNA gap filling (GO:0006297)2.78337238
50deoxyribose phosphate metabolic process (GO:0019692)2.77328695
51regulation of dendritic cell antigen processing and presentation (GO:0002604)2.74411396
52protein neddylation (GO:0045116)2.74005850
53regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.71507388
54negative thymic T cell selection (GO:0045060)2.71015823
55purinergic nucleotide receptor signaling pathway (GO:0035590)2.69543757
56tryptophan metabolic process (GO:0006568)2.67335958
57negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.66787030
58negative T cell selection (GO:0043383)2.65779130
59negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.64316622
60deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.63571216
61regulation of nuclear cell cycle DNA replication (GO:0033262)2.63338882
62positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.62957131
63phosphorylated carbohydrate dephosphorylation (GO:0046838)2.62012803
64inositol phosphate dephosphorylation (GO:0046855)2.62012803
65nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.61838514
66base-excision repair, AP site formation (GO:0006285)2.60381938
67negative regulation of mRNA processing (GO:0050686)2.60288381
68proteasome assembly (GO:0043248)2.59072972
69deoxyribonucleotide metabolic process (GO:0009262)2.58789744
70purine-containing compound salvage (GO:0043101)2.57801489
71mitotic recombination (GO:0006312)2.56803358
72positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.56729409
73tRNA modification (GO:0006400)2.56320719
74negative regulation of ligase activity (GO:0051352)2.54259524
75negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.54259524
76exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.52698405
77negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.52532532
78cullin deneddylation (GO:0010388)2.52375890
79tRNA processing (GO:0008033)2.52206055
80glutathione biosynthetic process (GO:0006750)2.51688533
81platelet dense granule organization (GO:0060155)2.50444461
82tyrosine phosphorylation of STAT protein (GO:0007260)2.49710454
83peptidyl-arginine omega-N-methylation (GO:0035247)2.48704225
84regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.48171857
85folic acid-containing compound biosynthetic process (GO:0009396)2.43323363
86replication fork processing (GO:0031297)2.41929392
87mannosylation (GO:0097502)2.41284500
88signal transduction involved in DNA damage checkpoint (GO:0072422)2.41156224
89signal transduction involved in DNA integrity checkpoint (GO:0072401)2.41156224
90positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.41138905
91innate immune response in mucosa (GO:0002227)2.40708531
92fucose metabolic process (GO:0006004)2.40365016
93signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.40202515
94signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.40202515
95signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.40202515
96pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.39978156
97organelle membrane fusion (GO:0090174)2.39321709
98antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.38672802
99anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.38064923
100regulation of thymocyte apoptotic process (GO:0070243)2.37886326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.67809172
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.17107283
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.09584692
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.79639709
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76101919
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.58051383
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.56650773
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.41694624
9MYC_22102868_ChIP-Seq_BL_Human2.32141212
10CIITA_25753668_ChIP-Seq_RAJI_Human2.28594532
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.25192407
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.24690885
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.22249211
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.18679897
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.14562909
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.10411134
17VDR_21846776_ChIP-Seq_THP-1_Human2.08449123
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08080057
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.06284042
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.00813447
21FOXP3_21729870_ChIP-Seq_TREG_Human2.00295655
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.98122182
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98080558
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.97732687
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.97520062
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91014353
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.90103310
28VDR_23849224_ChIP-Seq_CD4+_Human1.89646294
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.86823201
30XRN2_22483619_ChIP-Seq_HELA_Human1.84550416
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83461195
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81265905
33DCP1A_22483619_ChIP-Seq_HELA_Human1.79894102
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.76635862
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.74113887
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70168735
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69391668
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.69334963
39GABP_19822575_ChIP-Seq_HepG2_Human1.68163354
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.67656333
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.66047503
42ERG_20887958_ChIP-Seq_HPC-7_Mouse1.65500603
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.65205210
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62780005
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60654322
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58129901
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.55996643
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55439014
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54126908
50HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.52114177
51DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.51630398
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.51218769
53MAF_26560356_Chip-Seq_TH1_Human1.50062089
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49392009
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.47905594
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47873698
57VDR_24763502_ChIP-Seq_THP-1_Human1.47339762
58KDM5A_27292631_Chip-Seq_BREAST_Human1.45717874
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.45241094
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.44683158
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.43381748
62SPI1_23547873_ChIP-Seq_NB4_Human1.43193221
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42456885
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41072857
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38751643
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37949841
67MAF_26560356_Chip-Seq_TH2_Human1.36045799
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34796967
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34029425
70ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33584416
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.32764999
72UTX_26944678_Chip-Seq_JUKART_Human1.32316848
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31873833
74RUNX1_22412390_ChIP-Seq_EML_Mouse1.30183333
75P68_20966046_ChIP-Seq_HELA_Human1.28668329
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28045641
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28000097
78BCOR_27268052_Chip-Seq_Bcells_Human1.22414517
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22367123
80E2F1_21310950_ChIP-Seq_MCF-7_Human1.21518886
81MYB_26560356_Chip-Seq_TH2_Human1.21179928
82TTF2_22483619_ChIP-Seq_HELA_Human1.21156819
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19368648
84BCL6_27268052_Chip-Seq_Bcells_Human1.19198710
85SCL_19346495_ChIP-Seq_HPC-7_Human1.19061657
86E2F1_20622854_ChIP-Seq_HELA_Human1.18683758
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16182699
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13066553
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12324840
90FOXP1_21924763_ChIP-Seq_HESCs_Human1.11509746
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10812930
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10362695
93TFEB_21752829_ChIP-Seq_HELA_Human1.10179942
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.08940225
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08774321
96MYB_26560356_Chip-Seq_TH1_Human1.08537114
97BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07613265
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06761538
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06728605
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06694612

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.99471109
2MP0003111_abnormal_nucleus_morphology3.41805233
3MP0003693_abnormal_embryo_hatching3.29243584
4MP0009697_abnormal_copulation3.12695783
5MP0010094_abnormal_chromosome_stability2.94157814
6MP0009278_abnormal_bone_marrow2.87600055
7MP0005464_abnormal_platelet_physiology2.75924349
8MP0002396_abnormal_hematopoietic_system2.75000181
9MP0003806_abnormal_nucleotide_metabolis2.64009376
10MP0002138_abnormal_hepatobiliary_system2.57097838
11MP0005075_abnormal_melanosome_morpholog2.35873562
12MP0005397_hematopoietic_system_phenotyp2.26102500
13MP0001545_abnormal_hematopoietic_system2.26102500
14MP0000685_abnormal_immune_system2.21477987
15MP0005645_abnormal_hypothalamus_physiol2.21460157
16MP0002166_altered_tumor_susceptibility2.20496248
17MP0000465_gastrointestinal_hemorrhage2.17485135
18MP0003077_abnormal_cell_cycle2.16032091
19MP0005000_abnormal_immune_tolerance2.05731273
20MP0002398_abnormal_bone_marrow2.03321723
21MP0008058_abnormal_DNA_repair2.01160840
22MP0001800_abnormal_humoral_immune1.89830653
23MP0004957_abnormal_blastocyst_morpholog1.88041975
24MP0002019_abnormal_tumor_incidence1.85674929
25MP0003303_peritoneal_inflammation1.80677098
26MP0002006_tumorigenesis1.80276531
27MP0002452_abnormal_antigen_presenting1.77534825
28MP0005671_abnormal_response_to1.76005287
29MP0002148_abnormal_hypersensitivity_rea1.75510187
30MP0004808_abnormal_hematopoietic_stem1.71444906
31MP0006036_abnormal_mitochondrial_physio1.70324854
32MP0002420_abnormal_adaptive_immunity1.70216512
33MP0003724_increased_susceptibility_to1.69661701
34MP0003436_decreased_susceptibility_to1.68582018
35MP0001819_abnormal_immune_cell1.67802919
36MP0002723_abnormal_immune_serum1.66408884
37MP0000689_abnormal_spleen_morphology1.64465716
38MP0002429_abnormal_blood_cell1.61872966
39MP0008007_abnormal_cellular_replicative1.60036360
40MP0002722_abnormal_immune_system1.59357880
41MP0000716_abnormal_immune_system1.59201436
42MP0001790_abnormal_immune_system1.56948402
43MP0005387_immune_system_phenotype1.56948402
44MP0005025_abnormal_response_to1.54183991
45MP0005058_abnormal_lysosome_morphology1.53144453
46MP0003718_maternal_effect1.52541131
47MP0009785_altered_susceptibility_to1.49654452
48MP0008961_abnormal_basal_metabolism1.44683847
49MP0009333_abnormal_splenocyte_physiolog1.41775093
50MP0008872_abnormal_physiological_respon1.38885644
51MP0003763_abnormal_thymus_physiology1.36750027
52MP0002405_respiratory_system_inflammati1.35982324
53MP0001873_stomach_inflammation1.35838282
54MP0002419_abnormal_innate_immunity1.33761061
55MP0008995_early_reproductive_senescence1.32930933
56MP0000703_abnormal_thymus_morphology1.32349052
57MP0000490_abnormal_crypts_of1.29108660
58MP0008932_abnormal_embryonic_tissue1.26931813
59MP0003252_abnormal_bile_duct1.24729887
60MP0000313_abnormal_cell_death1.22389447
61MP0003786_premature_aging1.20546683
62MP0005220_abnormal_exocrine_pancreas1.19917861
63MP0010155_abnormal_intestine_physiology1.17692918
64MP0010307_abnormal_tumor_latency1.15594862
65MP0001845_abnormal_inflammatory_respons1.10701423
66MP0005084_abnormal_gallbladder_morpholo1.05951969
67MP0003172_abnormal_lysosome_physiology1.05483426
68MP0004381_abnormal_hair_follicle1.00262552
69MP0008057_abnormal_DNA_replication0.98952333
70MP0009764_decreased_sensitivity_to0.98863590
71MP0005451_abnormal_body_composition0.97715982
72MP0001853_heart_inflammation0.97361286
73MP0006035_abnormal_mitochondrial_morpho0.96196728
74MP0008875_abnormal_xenobiotic_pharmacok0.94192996
75MP0005410_abnormal_fertilization0.92435671
76MP0000350_abnormal_cell_proliferation0.88229789
77MP0000358_abnormal_cell_content/0.86465853
78MP0002089_abnormal_postnatal_growth/wei0.84446907
79MP0005501_abnormal_skin_physiology0.80920269
80MP0002332_abnormal_exercise_endurance0.78053835
81MP0008469_abnormal_protein_level0.77729026
82MP0002132_abnormal_respiratory_system0.76594344
83MP0008873_increased_physiological_sensi0.76046344
84MP0000858_altered_metastatic_potential0.75887502
85MP0003866_abnormal_defecation0.75700586
86MP0001764_abnormal_homeostasis0.73064890
87MP0000015_abnormal_ear_pigmentation0.69261299
88MP0002080_prenatal_lethality0.67062411
89MP0004947_skin_inflammation0.66157022
90MP0001730_embryonic_growth_arrest0.65191155
91MP0001663_abnormal_digestive_system0.64395163
92MP0001533_abnormal_skeleton_physiology0.63696717
93MP0009763_increased_sensitivity_to0.63430427
94MP0004233_abnormal_muscle_weight0.62601906
95MP0005266_abnormal_metabolism0.62319447
96MP0005621_abnormal_cell_physiology0.62095319
97MP0003191_abnormal_cellular_cholesterol0.61310653
98MP0003186_abnormal_redox_activity0.60632906
99MP0005384_cellular_phenotype0.59472926
100MP0009765_abnormal_xenobiotic_induced0.58934685

Predicted human phenotypes

RankGene SetZ-score
1Prostate neoplasm (HP:0100787)4.04326907
2Abnormality of B cell number (HP:0010975)3.72467864
3Petechiae (HP:0000967)3.69139846
4Abnormality of the prostate (HP:0008775)3.52095344
5B lymphocytopenia (HP:0010976)3.48671321
6Hypomagnesemia (HP:0002917)3.45081038
7Agammaglobulinemia (HP:0004432)3.37026627
8Aplastic anemia (HP:0001915)3.33467281
9Microvesicular hepatic steatosis (HP:0001414)3.29657580
10Abnormal number of erythroid precursors (HP:0012131)3.23488418
11Elevated erythrocyte sedimentation rate (HP:0003565)3.19466382
12Hypoplasia of the capital femoral epiphysis (HP:0003090)3.17503470
13Panhypogammaglobulinemia (HP:0003139)3.17501597
14Hyperacusis (HP:0010780)3.08407921
15Abnormality of lateral ventricle (HP:0030047)2.98872829
16Prolonged bleeding time (HP:0003010)2.98012837
17Abnormality of magnesium homeostasis (HP:0004921)2.94483434
18Recurrent fungal infections (HP:0002841)2.87106174
19Overriding aorta (HP:0002623)2.75607598
20Elfin facies (HP:0004428)2.75466429
21Cellulitis (HP:0100658)2.64170166
22Increased serum lactate (HP:0002151)2.63162385
23Myelodysplasia (HP:0002863)2.62875947
24Decreased electroretinogram (ERG) amplitude (HP:0000654)2.62577083
25Progressive muscle weakness (HP:0003323)2.61663484
26Chronic obstructive pulmonary disease (HP:0006510)2.61558932
27Obstructive lung disease (HP:0006536)2.61558932
28Epistaxis (HP:0000421)2.61201644
29Abnormal delayed hypersensitivity skin test (HP:0002963)2.56303202
30Mesangial abnormality (HP:0001966)2.53398484
31Hypertensive crisis (HP:0100735)2.52090618
32Acute lymphatic leukemia (HP:0006721)2.50625839
33Dyschromatopsia (HP:0007641)2.50154856
34Increased intramyocellular lipid droplets (HP:0012240)2.48954187
35Absent thumb (HP:0009777)2.48951308
36Dicarboxylic aciduria (HP:0003215)2.48633380
37Abnormality of dicarboxylic acid metabolism (HP:0010995)2.48633380
38Abnormality of cells of the erythroid lineage (HP:0012130)2.47982945
39Abnormal mitochondria in muscle tissue (HP:0008316)2.43973247
40Hepatocellular necrosis (HP:0001404)2.43655406
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.41499356
42Squamous cell carcinoma (HP:0002860)2.40932348
43Abnormality of the carotid arteries (HP:0005344)2.40545105
44Meningitis (HP:0001287)2.38330397
45Recurrent viral infections (HP:0004429)2.36337808
46Hepatic necrosis (HP:0002605)2.34469049
47Absent epiphyses (HP:0010577)2.33369150
48Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.33369150
49Chronic mucocutaneous candidiasis (HP:0002728)2.33154607
50Recurrent cutaneous fungal infections (HP:0011370)2.33154607
51Abnormality of T cell physiology (HP:0011840)2.30463905
52Testicular atrophy (HP:0000029)2.30251691
53Increased muscle lipid content (HP:0009058)2.29758405
54Abnormality of male internal genitalia (HP:0000022)2.29745781
55Autoimmune thrombocytopenia (HP:0001973)2.27175754
56Autoimmune hemolytic anemia (HP:0001890)2.26806680
57Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23951462
58Mediastinal lymphadenopathy (HP:0100721)2.19933205
59Increased serum ferritin (HP:0003281)2.17721392
60Birth length less than 3rd percentile (HP:0003561)2.17080521
61Acute necrotizing encephalopathy (HP:0006965)2.16949927
62Delayed CNS myelination (HP:0002188)2.15501047
63Severe combined immunodeficiency (HP:0004430)2.15224943
64Abnormality of the preputium (HP:0100587)2.13526887
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.12020585
66Flat cornea (HP:0007720)2.06864328
67Granulocytopenia (HP:0001913)2.06119476
68Prominent nose (HP:0000448)2.05475754
69Abnormality of T cells (HP:0002843)2.05256987
70Mitochondrial inheritance (HP:0001427)2.04857999
71Progressive microcephaly (HP:0000253)2.01442490
72Bone marrow hypocellularity (HP:0005528)2.00946647
73Pulmonary fibrosis (HP:0002206)1.97948457
74Lactic acidosis (HP:0003128)1.96883621
75Aplasia/Hypoplasia of the thymus (HP:0010515)1.96227136
76Renovascular hypertension (HP:0100817)1.94225925
77Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.93489704
78Decreased activity of mitochondrial respiratory chain (HP:0008972)1.93489704
79Increased CSF lactate (HP:0002490)1.93458136
80Poor head control (HP:0002421)1.93079227
81Large eyes (HP:0001090)1.92541361
82Attenuation of retinal blood vessels (HP:0007843)1.91982266
83Abolished electroretinogram (ERG) (HP:0000550)1.91089637
84Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90476746
85Insomnia (HP:0100785)1.89180200
86Hypercalciuria (HP:0002150)1.88273163
87Aplasia/Hypoplasia of the uvula (HP:0010293)1.86682150
88Encephalitis (HP:0002383)1.86081296
89Increased IgE level (HP:0003212)1.84020073
90Type I transferrin isoform profile (HP:0003642)1.81566476
91Microretrognathia (HP:0000308)1.81316752
92J-shaped sella turcica (HP:0002680)1.81195663
93Chromsome breakage (HP:0040012)1.80109792
94Combined immunodeficiency (HP:0005387)1.79111567
95Abnormality of iron homeostasis (HP:0011031)1.78861254
96Chest pain (HP:0100749)1.78837213
97Clubbing of toes (HP:0100760)1.78448909
98Pancytopenia (HP:0001876)1.78272275
99Exercise intolerance (HP:0003546)1.77962008
100Renal Fanconi syndrome (HP:0001994)1.76843773

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.92632296
2TLK14.69908458
3SCYL24.17765499
4ERN13.19600023
5BUB12.83722086
6MAP4K12.64854697
7KIT2.53010924
8BCKDK2.22001120
9KDR2.10048403
10NUAK12.09398085
11MST42.08624260
12TAOK32.07473091
13TESK21.95077283
14CDK121.91888935
15NME21.89081573
16SIK31.85064478
17STK41.84150888
18VRK11.80016087
19VRK21.70563831
20TBK11.60492776
21CDK81.59557111
22CDC71.46810222
23ATR1.37958264
24PIM21.37577831
25FLT31.37520113
26MAP4K21.36869222
27IKBKB1.34524045
28CSF1R1.25859985
29STK161.22418565
30SYK1.22185415
31MAP2K31.20016829
32PBK1.19049508
33EIF2AK11.17050184
34RPS6KA51.16359345
35MAP3K141.15361515
36IKBKE1.11700398
37IRAK41.11641981
38SMG11.11590114
39FER1.03690362
40GRK61.02445045
41CDK90.96928729
42AURKA0.95177690
43SIK10.92657095
44MAP3K30.90336646
45MAP3K80.90334046
46MAPK110.89320109
47JAK30.84534166
48CDK40.83402060
49CCNB10.83365327
50IRAK30.82038915
51AURKB0.81320354
52BTK0.80038386
53CHEK20.78913371
54SIK20.77129542
55FES0.75937577
56SRPK10.74821386
57MAPKAPK30.73691855
58DYRK30.72433442
59LYN0.71324129
60BMX0.70381193
61PIM10.69745638
62IRAK20.68202623
63CDK70.66891529
64PLK10.66164036
65RPS6KB20.64668819
66RPS6KA40.62638691
67MAP3K130.61756754
68MAP3K110.61485260
69BLK0.56037619
70MARK30.55269917
71DAPK10.53140214
72CHEK10.50057207
73TRIM280.49947818
74STK100.48567918
75PLK40.48142753
76CHUK0.47708168
77MAP2K20.46491400
78TNK20.46023645
79TEC0.45676804
80TTK0.43754189
81PRKCI0.42149219
82RIPK40.42042681
83HIPK20.41130657
84EIF2AK30.40332332
85AKT20.37768106
86IRAK10.37246623
87DAPK30.34036696
88BMPR1B0.32482207
89ATM0.32200804
90PRKCQ0.31214180
91MATK0.30026590
92MAP3K10.29256903
93EIF2AK20.29098383
94PKN20.28614604
95MAPKAPK20.28586275
96CDK20.25266389
97MAP3K20.24866942
98ARAF0.24089178
99DYRK1B0.23935127
100PAK10.22970814

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.27701047
2Asthma_Homo sapiens_hsa053103.77526487
3Allograft rejection_Homo sapiens_hsa053303.47702061
4DNA replication_Homo sapiens_hsa030303.26373031
5Autoimmune thyroid disease_Homo sapiens_hsa053203.09939233
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.08519928
7Graft-versus-host disease_Homo sapiens_hsa053322.95973768
8Proteasome_Homo sapiens_hsa030502.70295555
9Type I diabetes mellitus_Homo sapiens_hsa049402.62845664
10Mismatch repair_Homo sapiens_hsa034302.45588358
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.39280626
12Alcoholism_Homo sapiens_hsa050342.26710305
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.16876604
14Antigen processing and presentation_Homo sapiens_hsa046122.11135692
15Base excision repair_Homo sapiens_hsa034102.04370941
16Fatty acid elongation_Homo sapiens_hsa000621.92598438
17Leishmaniasis_Homo sapiens_hsa051401.91589565
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.86600595
19Primary immunodeficiency_Homo sapiens_hsa053401.84193169
20Viral myocarditis_Homo sapiens_hsa054161.83397390
21RNA polymerase_Homo sapiens_hsa030201.78488635
22Homologous recombination_Homo sapiens_hsa034401.70213764
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61154113
24Herpes simplex infection_Homo sapiens_hsa051681.59067811
25Nucleotide excision repair_Homo sapiens_hsa034201.56843495
26Staphylococcus aureus infection_Homo sapiens_hsa051501.56210700
27Fanconi anemia pathway_Homo sapiens_hsa034601.54570681
28Spliceosome_Homo sapiens_hsa030401.44888351
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43902987
30Pyrimidine metabolism_Homo sapiens_hsa002401.37991033
31Viral carcinogenesis_Homo sapiens_hsa052031.35446314
32Sulfur relay system_Homo sapiens_hsa041221.21087623
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18825730
34Hematopoietic cell lineage_Homo sapiens_hsa046401.16719115
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16634187
36Non-homologous end-joining_Homo sapiens_hsa034501.13985481
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13656204
38One carbon pool by folate_Homo sapiens_hsa006701.13238775
39Cell cycle_Homo sapiens_hsa041101.10821749
40Rheumatoid arthritis_Homo sapiens_hsa053231.03212994
41Sulfur metabolism_Homo sapiens_hsa009201.01650877
42Pyruvate metabolism_Homo sapiens_hsa006201.00591371
43Purine metabolism_Homo sapiens_hsa002300.99540554
44RNA degradation_Homo sapiens_hsa030180.98954200
45RNA transport_Homo sapiens_hsa030130.96579125
46Epstein-Barr virus infection_Homo sapiens_hsa051690.90883376
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88615662
48Tuberculosis_Homo sapiens_hsa051520.88058000
49Influenza A_Homo sapiens_hsa051640.87231166
50Toxoplasmosis_Homo sapiens_hsa051450.83049237
51Parkinsons disease_Homo sapiens_hsa050120.81745386
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79210772
53HTLV-I infection_Homo sapiens_hsa051660.73151059
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69497438
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66303380
56Ribosome_Homo sapiens_hsa030100.61355842
57Platelet activation_Homo sapiens_hsa046110.58002485
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56664047
59Pentose phosphate pathway_Homo sapiens_hsa000300.54974402
60Oxidative phosphorylation_Homo sapiens_hsa001900.53363795
61Glutathione metabolism_Homo sapiens_hsa004800.52728989
62Arachidonic acid metabolism_Homo sapiens_hsa005900.52403041
63Tryptophan metabolism_Homo sapiens_hsa003800.51750265
64Lysine degradation_Homo sapiens_hsa003100.51343382
65p53 signaling pathway_Homo sapiens_hsa041150.50344600
66B cell receptor signaling pathway_Homo sapiens_hsa046620.49767883
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48749921
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45134938
69Measles_Homo sapiens_hsa051620.44277723
70Legionellosis_Homo sapiens_hsa051340.44061911
71Carbon metabolism_Homo sapiens_hsa012000.43823622
72Basal transcription factors_Homo sapiens_hsa030220.40641577
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.37452428
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.37006030
75Folate biosynthesis_Homo sapiens_hsa007900.36633959
76Huntingtons disease_Homo sapiens_hsa050160.36312569
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35174251
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34932505
79Phagosome_Homo sapiens_hsa041450.33675674
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32970347
81N-Glycan biosynthesis_Homo sapiens_hsa005100.32885245
82Selenocompound metabolism_Homo sapiens_hsa004500.31715573
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31010132
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30865821
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30682126
86Biosynthesis of amino acids_Homo sapiens_hsa012300.28836012
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28272542
88Apoptosis_Homo sapiens_hsa042100.26864333
89Fatty acid metabolism_Homo sapiens_hsa012120.26443396
90Peroxisome_Homo sapiens_hsa041460.25257437
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24159307
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.23780376
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.22675464
94Metabolic pathways_Homo sapiens_hsa011000.22178890
95Shigellosis_Homo sapiens_hsa051310.21346467
96Fructose and mannose metabolism_Homo sapiens_hsa000510.21165981
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19830263
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19366580
99Protein export_Homo sapiens_hsa030600.18725312
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18718534

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