HIST2H2BE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. The protein has antibacterial and antifungal antimicrobial activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to cilium (GO:0061512)9.68385786
2* mucosal immune response (GO:0002385)8.30181120
3* organ or tissue specific immune response (GO:0002251)7.58739338
4* antibacterial humoral response (GO:0019731)7.51388737
5regulation of chromatin binding (GO:0035561)7.43884822
6regulation of female gonad development (GO:2000194)7.06327869
7* antimicrobial humoral response (GO:0019730)6.92102905
8regulation of cilium movement (GO:0003352)6.78810874
9protein polyglutamylation (GO:0018095)6.59258612
10adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)6.48694494
11auditory receptor cell differentiation (GO:0042491)6.35265156
12* nucleosome assembly (GO:0006334)6.15412232
13axonemal dynein complex assembly (GO:0070286)5.98108775
14intraciliary transport (GO:0042073)5.81967014
15definitive hemopoiesis (GO:0060216)5.51936300
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.42294252
17axoneme assembly (GO:0035082)5.40817230
18cilium movement (GO:0003341)5.19144381
19* nucleosome organization (GO:0034728)5.15336874
20* protein-DNA complex assembly (GO:0065004)5.10752682
21DNA replication-dependent nucleosome organization (GO:0034723)5.10628763
22DNA replication-dependent nucleosome assembly (GO:0006335)5.10628763
23cilium morphogenesis (GO:0060271)5.06330691
24thrombin receptor signaling pathway (GO:0070493)4.97723535
25regulation of histone H3-K9 methylation (GO:0051570)4.96967886
26chromatin assembly (GO:0031497)4.95864131
27neutrophil activation involved in immune response (GO:0002283)4.94093648
28photoreceptor cell maintenance (GO:0045494)4.79996011
29negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.77600741
30microtubule severing (GO:0051013)4.68667302
31megakaryocyte development (GO:0035855)4.50304561
32* protein-DNA complex subunit organization (GO:0071824)4.41275609
33epithelial cilium movement (GO:0003351)4.40169862
34adipose tissue development (GO:0060612)4.36689379
35positive regulation of granulocyte differentiation (GO:0030854)4.34620152
36olfactory bulb development (GO:0021772)4.29485525
37activation of protein kinase A activity (GO:0034199)4.27683613
38negative regulation of T-helper cell differentiation (GO:0045623)4.24517819
39negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.24517819
40negative regulation of cytosolic calcium ion concentration (GO:0051481)4.22810239
41regulation of megakaryocyte differentiation (GO:0045652)4.15828939
42natural killer cell mediated cytotoxicity (GO:0042267)4.12445796
43natural killer cell mediated immunity (GO:0002228)4.12445796
44detection of calcium ion (GO:0005513)4.09193142
45phosphorelay signal transduction system (GO:0000160)3.96953336
46response to caffeine (GO:0031000)3.96940837
47regulation of integrin activation (GO:0033623)3.90816486
48hair cell differentiation (GO:0035315)3.80634105
49cAMP biosynthetic process (GO:0006171)3.80523104
50* defense response to Gram-positive bacterium (GO:0050830)3.79117973
51behavioral response to cocaine (GO:0048148)3.74858520
52dopamine receptor signaling pathway (GO:0007212)3.74125868
53negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.72475377
54leukocyte migration involved in inflammatory response (GO:0002523)3.71990947
55membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.71142166
56regulation of microtubule-based movement (GO:0060632)3.70000813
57regulation of memory T cell differentiation (GO:0043380)3.68902680
58inner ear receptor cell differentiation (GO:0060113)3.68595585
59G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.64120853
60cellular response to glucagon stimulus (GO:0071377)3.62133858
61purinergic nucleotide receptor signaling pathway (GO:0035590)3.61676043
62negative regulation of erythrocyte differentiation (GO:0045647)3.58476141
63germinal center formation (GO:0002467)3.58374690
64motile cilium assembly (GO:0044458)3.54306965
65protein heterotetramerization (GO:0051290)3.48807036
66regulation of platelet aggregation (GO:0090330)3.47724093
67chemical homeostasis within a tissue (GO:0048875)3.41288660
68microtubule bundle formation (GO:0001578)3.40661644
69magnesium ion transport (GO:0015693)3.39371872
70regulation of T-helper 2 cell differentiation (GO:0045628)3.37780150
71histone demethylation (GO:0016577)3.37313871
72negative regulation of complement activation (GO:0045916)3.36697708
73membrane repolarization during action potential (GO:0086011)3.34292746
74regulation of heart rate by cardiac conduction (GO:0086091)3.33237146
75cilium or flagellum-dependent cell motility (GO:0001539)3.29947015
76negative regulation of thymocyte apoptotic process (GO:0070244)3.28328881
77histone lysine demethylation (GO:0070076)3.27907620
78left/right axis specification (GO:0070986)3.25110763
79regulation of sodium ion transmembrane transporter activity (GO:2000649)3.25017493
80B cell receptor signaling pathway (GO:0050853)3.24718558
81platelet formation (GO:0030220)3.24068024
82cellular response to electrical stimulus (GO:0071257)3.23231060
83platelet aggregation (GO:0070527)3.22357246
84myeloid cell development (GO:0061515)3.21863573
85regulation of erythrocyte differentiation (GO:0045646)3.17145568
86cilium assembly (GO:0042384)3.16775825
87regulation of platelet activation (GO:0010543)3.14697148
88nuclear pore complex assembly (GO:0051292)3.14653121
89granulocyte differentiation (GO:0030851)3.13720522
90relaxation of cardiac muscle (GO:0055119)3.12461714
91regulation of hematopoietic progenitor cell differentiation (GO:1901532)3.12276647
92dosage compensation (GO:0007549)3.11325513
93mature B cell differentiation involved in immune response (GO:0002313)3.09974843
94nonmotile primary cilium assembly (GO:0035058)3.09340104
95positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.09029249
96immunoglobulin mediated immune response (GO:0016064)3.07522561
97regulation of cell communication by electrical coupling (GO:0010649)3.07439227
98sensory perception of taste (GO:0050909)3.07425466
99cilium organization (GO:0044782)3.05957376
100protein neddylation (GO:0045116)3.03872158
101regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.03753088
102positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.01516873
103calcium-mediated signaling using intracellular calcium source (GO:0035584)3.01196313
104sensory perception of smell (GO:0007608)24.0706020
105negative regulation of norepinephrine secretion (GO:0010700)2.99645394
106positive regulation of mast cell activation (GO:0033005)2.98785493
107detection of light stimulus involved in visual perception (GO:0050908)2.98450809
108detection of light stimulus involved in sensory perception (GO:0050962)2.98450809
109regulation of germinal center formation (GO:0002634)2.97012012
110melanosome transport (GO:0032402)2.96768883
111negative regulation of transcription regulatory region DNA binding (GO:2000678)2.96165900
112positive regulation of B cell differentiation (GO:0045579)2.96072625
113adenosine receptor signaling pathway (GO:0001973)2.95757175
114neuroblast proliferation (GO:0007405)2.95731006
115potassium ion transmembrane transport (GO:0071805)2.93631969
116cellular potassium ion transport (GO:0071804)2.93631969
117negative regulation of astrocyte differentiation (GO:0048712)2.93283605
118glycogen catabolic process (GO:0005980)2.93257298
119polyamine biosynthetic process (GO:0006596)2.93079457
120response to gravity (GO:0009629)2.92524481
121microtubule depolymerization (GO:0007019)2.91010263
122oxygen transport (GO:0015671)2.90202288
123neutrophil activation (GO:0042119)2.90180619
124response to amphetamine (GO:0001975)2.88657921
125protein demethylation (GO:0006482)2.88435914
126protein dealkylation (GO:0008214)2.88435914
127potassium ion homeostasis (GO:0055075)2.87375147
128atrial cardiac muscle cell action potential (GO:0086014)2.86829942
129melanosome localization (GO:0032400)2.85487870
130neuron cell-cell adhesion (GO:0007158)2.84936751
131L-fucose catabolic process (GO:0042355)2.84702918
132fucose catabolic process (GO:0019317)2.84702918
133L-fucose metabolic process (GO:0042354)2.84702918
134mechanoreceptor differentiation (GO:0042490)2.84340915
135B cell mediated immunity (GO:0019724)2.84057783
136positive regulation of insulin receptor signaling pathway (GO:0046628)2.84049905
137growth hormone receptor signaling pathway (GO:0060396)2.82856063
138peptidyl-glutamic acid modification (GO:0018200)2.82037775
139regulation of granulocyte differentiation (GO:0030852)2.81778375
140snRNA transcription (GO:0009301)2.81480971
141negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.80962211
142pigment granule transport (GO:0051904)2.80380930
143response to glucagon (GO:0033762)2.79565708
144brain morphogenesis (GO:0048854)2.78110120
145positive regulation of endothelial cell differentiation (GO:0045603)2.77779897
146ventricular system development (GO:0021591)2.76666591
147positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.76260877
148negative regulation of glycogen biosynthetic process (GO:0045719)2.76103378
149connective tissue development (GO:0061448)2.74862045
150hepatocyte apoptotic process (GO:0097284)2.74703742
151positive regulation of T cell cytokine production (GO:0002726)2.74691533
152regulation of sodium ion transmembrane transport (GO:1902305)2.74308007
153mating behavior (GO:0007617)2.74057996
154interkinetic nuclear migration (GO:0022027)2.73835412
155cardiac conduction (GO:0061337)2.73310971
156establishment of melanosome localization (GO:0032401)2.72057353
157pigment granule localization (GO:0051875)2.71618454
158negative regulation of protein activation cascade (GO:2000258)2.71616816
159cellular copper ion homeostasis (GO:0006878)2.70811381
160glucan catabolic process (GO:0009251)2.70248103
161negative regulation of microtubule polymerization (GO:0031115)2.69480964
162positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.68594831
163lipoxygenase pathway (GO:0019372)2.68338388
164negative regulation of humoral immune response (GO:0002921)2.68078764
165histone H2B ubiquitination (GO:0033523)2.67427651
166chromatin assembly or disassembly (GO:0006333)2.67230821
167poly(A)+ mRNA export from nucleus (GO:0016973)2.67051615
168nuclear pore organization (GO:0006999)2.66438407
169neurogenesis (GO:0022008)2.66282079
170purinergic receptor signaling pathway (GO:0035587)2.65806609
171regulation of hypersensitivity (GO:0002883)2.63661526
172negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.60877902
173mature B cell differentiation (GO:0002335)2.60320356
174pore complex assembly (GO:0046931)2.58764286
175negative regulation of B cell apoptotic process (GO:0002903)2.58302637
176positive regulation of protein homodimerization activity (GO:0090073)2.57212986
177negative regulation of alpha-beta T cell differentiation (GO:0046639)2.56683261
178regulation of T-helper 1 cell differentiation (GO:0045625)2.55396834
179negative regulation of histone methylation (GO:0031061)2.54937230
180embryonic process involved in female pregnancy (GO:0060136)2.54567814
181positive regulation of cAMP-mediated signaling (GO:0043950)2.53990609
182regulation of cAMP-dependent protein kinase activity (GO:2000479)2.50117891
183cellular response to growth hormone stimulus (GO:0071378)2.49575938
184negative regulation of lymphocyte apoptotic process (GO:0070229)2.48737855
185positive regulation of systemic arterial blood pressure (GO:0003084)2.48171759
186positive regulation of erythrocyte differentiation (GO:0045648)2.48064484
187response to peptidoglycan (GO:0032494)2.46773520
188regulation of myeloid leukocyte mediated immunity (GO:0002886)2.46294736
189regulation of B cell apoptotic process (GO:0002902)2.46136095
190peptidyl-lysine dimethylation (GO:0018027)2.45594789
191cellular extravasation (GO:0045123)2.43831809
192regulation of Golgi to plasma membrane protein transport (GO:0042996)2.43733231
193regulation of mast cell degranulation (GO:0043304)2.43635820
194regulation of B cell receptor signaling pathway (GO:0050855)2.43173606
195regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.42963036
196regulation of mast cell activation involved in immune response (GO:0033006)2.39683589
197organelle membrane fusion (GO:0090174)2.37755236
198sensory perception of chemical stimulus (GO:0007606)14.0994741
199protein insertion into membrane (GO:0051205)11.8033339
200* innate immune response in mucosa (GO:0002227)10.0180249

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.12340207
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.45411298
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.03451961
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.46460411
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.30245571
6SCL_19346495_ChIP-Seq_HPC-7_Human3.02800004
7DROSHA_22980978_ChIP-Seq_HELA_Human2.81347136
8* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58157552
9ZNF263_19887448_ChIP-Seq_K562_Human2.55314170
10TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.48374187
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.46029937
12GATA1_22025678_ChIP-Seq_K562_Human2.30257897
13GBX2_23144817_ChIP-Seq_PC3_Human2.21788790
14BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.13933598
15HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse2.10863477
16GATA1_19941826_ChIP-Seq_K562_Human2.08573487
17LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08067002
18* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.07326349
19IRF1_19129219_ChIP-ChIP_H3396_Human2.05386647
20TAF15_26573619_Chip-Seq_HEK293_Human2.02966443
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01580896
22SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.97420881
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.89696481
24ETS1_22383799_ChIP-Seq_G1ME_Mouse1.89539257
25ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.87428981
26TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83962817
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.83962817
28* SOX2_16153702_ChIP-ChIP_HESCs_Human1.83100278
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.82691315
30GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.81642242
31GATA2_19941826_ChIP-Seq_K562_Human1.76938339
32E2F7_22180533_ChIP-Seq_HELA_Human1.72822857
33VDR_21846776_ChIP-Seq_THP-1_Human1.72226990
34AHR_22903824_ChIP-Seq_MCF-7_Human1.68806723
35* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67805998
36GATA1_26923725_Chip-Seq_HPCs_Mouse1.67651326
37* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66058349
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.63510813
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57682731
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57682731
41NR3C1_21868756_ChIP-Seq_MCF10A_Human1.57174283
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56074474
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55975384
44* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52445651
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52313118
46TDRD3_21172665_ChIP-Seq_MCF-7_Human1.50363651
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49309971
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48926541
49VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.48524665
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.48322118
51KDM2B_26808549_Chip-Seq_K562_Human1.46470026
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46230445
53SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46184278
54CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43752686
55IRF8_22096565_ChIP-ChIP_GC-B_Human1.43637683
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43003841
57* MAF_26560356_Chip-Seq_TH1_Human1.40096736
58* GATA3_27048872_Chip-Seq_THYMUS_Human1.39791286
59RNF2_27304074_Chip-Seq_NSC_Mouse1.39437544
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.38981981
61* RUNX1_22412390_ChIP-Seq_EML_Mouse1.38569740
62SPI1_23127762_ChIP-Seq_K562_Human1.37942066
63* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37409282
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35573498
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32733045
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32434038
67TCF7_22412390_ChIP-Seq_EML_Mouse1.31954280
68* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31052375
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30829986
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.30727366
71GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29647104
72CIITA_25753668_ChIP-Seq_RAJI_Human1.29258310
73* GATA1_19941827_ChIP-Seq_MEL_Mouse1.28893675
74* VDR_24763502_ChIP-Seq_THP-1_Human1.28414447
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28084662
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26007833
77SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25388809
78FOXM1_23109430_ChIP-Seq_U2OS_Human1.24406039
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23719535
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23038306
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.22376523
82VDR_22108803_ChIP-Seq_LS180_Human1.21231719
83REST_21632747_ChIP-Seq_MESCs_Mouse1.20976862
84SMAD4_21799915_ChIP-Seq_A2780_Human1.20552244
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.20031047
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19952054
87MYB_26560356_Chip-Seq_TH1_Human1.19609028
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.18440260
89RNF2_27304074_Chip-Seq_ESCs_Mouse1.17504324
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17266244
91* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16902349
92JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16748364
93SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16404766
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16136668
95UTX_26944678_Chip-Seq_JUKART_Human1.16123688
96SMAD4_21741376_ChIP-Seq_EPCs_Human1.15074301
97RUNX1_26923725_Chip-Seq_HPCs_Mouse1.14262471
98RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14151785
99SALL4_22934838_ChIP-ChIP_CD34+_Human1.12443878
100P300_19829295_ChIP-Seq_ESCs_Human1.12433151
101* NCOR1_26117541_ChIP-Seq_K562_Human1.12044869
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11950345
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11925340
104* MYB_26560356_Chip-Seq_TH2_Human1.11747383
105MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11615405
106RING1B_27294783_Chip-Seq_ESCs_Mouse1.11115908
107* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10910437
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09812452
109ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09321715
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09266302
111STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09217888
112* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08955541
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08739593
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08019507
115MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07923877
116IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04767847
117* EED_16625203_ChIP-ChIP_MESCs_Mouse1.04344584
118MYC_22102868_ChIP-Seq_BL_Human1.03146928
119SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01811402
120RARB_27405468_Chip-Seq_BRAIN_Mouse1.00515958
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.00352780
122SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00060516
123NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99724400
124SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98221910
125* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97705504
126WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94920925
127STAT1_20625510_ChIP-Seq_HELA_Human0.94673578
128TCF4_22108803_ChIP-Seq_LS180_Human0.94625605
129SPI1_23547873_ChIP-Seq_NB4_Human0.93424352
130GF1_26923725_Chip-Seq_HPCs_Mouse0.93321111
131NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.93016347
132RING1B_27294783_Chip-Seq_NPCs_Mouse0.92496401
133CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.92322888
134SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92099174
135FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91988851
136CDX2_22108803_ChIP-Seq_LS180_Human0.91571130
137* OCT4_20526341_ChIP-Seq_ESCs_Human0.91511632
138EZH2_27294783_Chip-Seq_ESCs_Mouse0.90671517
139CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89027613
140* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88899006
141PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88388749
142STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87994882
143SMAD3_21741376_ChIP-Seq_ESCs_Human0.87064287
144VDR_23849224_ChIP-Seq_CD4+_Human0.86630655
145TBX3_20139965_ChIP-Seq_ESCs_Mouse0.85263259
146TBX3_20139965_ChIP-Seq_MESCs_Mouse0.85054072
147ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84547875
148EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84404284
149* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84284535
150SMAD3_21741376_ChIP-Seq_EPCs_Human0.83588832
151SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83488740
152SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.83080020
153TAL1_26923725_Chip-Seq_HPCs_Mouse0.82974074
154CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.82381156
155CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82091613
156FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81966769
157TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81950538
158E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.81567071
159RUNX_20019798_ChIP-Seq_JUKART_Human0.80848190
160TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.80787871
161VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.80310966
162ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.79205856
163MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.79185063
164* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.78738859
165POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78374235
166LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.77735720
167SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.77222000
168* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.76865114
169RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76574617
170P53_22387025_ChIP-Seq_ESCs_Mouse0.76380224
171FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.75980178
172* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.74387762
173GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72982838
174Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72192067
175* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.71987515
176IRF8_27001747_Chip-Seq_BMDM_Mouse0.70610609
177GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.68991292
178STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.65013269
179* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.63318233
180KDM2B_26808549_Chip-Seq_DND41_Human0.63271007
181* KDM2B_26808549_Chip-Seq_JURKAT_Human0.63086571
182MAF_26560356_Chip-Seq_TH2_Human0.60668050
183SPI1_20517297_ChIP-Seq_HL60_Human0.58664883
184GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.58273147
185DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.58115554
186SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.57142282
187* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.56742292
188KDM5A_27292631_Chip-Seq_BREAST_Human0.53852141
189NANOG_16153702_ChIP-ChIP_HESCs_Human0.53312389

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology6.16613295
2MP0008789_abnormal_olfactory_epithelium5.22730276
3MP0005394_taste/olfaction_phenotype4.83242637
4MP0005499_abnormal_olfactory_system4.83242637
5MP0005645_abnormal_hypothalamus_physiol3.87639582
6MP0004808_abnormal_hematopoietic_stem2.95450055
7MP0005083_abnormal_biliary_tract2.90671462
8MP0000465_gastrointestinal_hemorrhage2.88396682
9MP0001835_abnormal_antigen_presentation2.82195354
10MP0008004_abnormal_stomach_pH2.76269649
11MP0008057_abnormal_DNA_replication2.74740280
12MP0003724_increased_susceptibility_to2.63901392
13MP0004084_abnormal_cardiac_muscle2.41891064
14MP0003656_abnormal_erythrocyte_physiolo2.27770067
15MP0001545_abnormal_hematopoietic_system2.23167024
16MP0005397_hematopoietic_system_phenotyp2.23167024
17MP0001485_abnormal_pinna_reflex2.15071329
18MP0002398_abnormal_bone_marrow2.02281655
19MP0002184_abnormal_innervation2.01359022
20MP0001984_abnormal_olfaction15.3713371
21MP0002166_altered_tumor_susceptibility1.99290545
22MP0008007_abnormal_cellular_replicative1.96132065
23MP0009278_abnormal_bone_marrow1.89657658
24MP0004381_abnormal_hair_follicle1.89103447
25MP0003303_peritoneal_inflammation1.88357262
26MP0004510_myositis1.81404746
27MP0004947_skin_inflammation1.76923357
28MP0004036_abnormal_muscle_relaxation1.76107615
29MP0002160_abnormal_reproductive_system1.73849134
30MP0003828_pulmonary_edema1.73828877
31MP0003806_abnormal_nucleotide_metabolis1.72061029
32MP0002396_abnormal_hematopoietic_system1.71798575
33MP0000372_irregular_coat_pigmentation1.67226306
34MP0001542_abnormal_bone_strength1.66240714
35MP0002928_abnormal_bile_duct1.65558170
36MP0000703_abnormal_thymus_morphology1.65377473
37MP0002722_abnormal_immune_system1.64325186
38MP0002138_abnormal_hepatobiliary_system1.55615201
39MP0005367_renal/urinary_system_phenotyp1.50275340
40MP0000516_abnormal_urinary_system1.50275340
41MP0000689_abnormal_spleen_morphology1.47227072
42MP0008775_abnormal_heart_ventricle1.45037771
43MP0001851_eye_inflammation1.44749017
44MP0001800_abnormal_humoral_immune1.43184637
45MP0002132_abnormal_respiratory_system1.40021260
46MP0003436_decreased_susceptibility_to1.38639675
47MP0010234_abnormal_vibrissa_follicle1.37305963
48MP0010155_abnormal_intestine_physiology1.36000301
49MP0002429_abnormal_blood_cell1.34967393
50MP0005000_abnormal_immune_tolerance1.33166949
51MP0002752_abnormal_somatic_nervous1.30710559
52MP0002877_abnormal_melanocyte_morpholog1.26362884
53MP0005410_abnormal_fertilization1.25156115
54MP0000716_abnormal_immune_system1.24944635
55MP0005551_abnormal_eye_electrophysiolog1.24300999
56MP0001293_anophthalmia1.23122515
57MP0000685_abnormal_immune_system1.23101279
58MP0002723_abnormal_immune_serum1.20634644
59MP0002332_abnormal_exercise_endurance1.20445891
60MP0005666_abnormal_adipose_tissue1.19984076
61MP0005084_abnormal_gallbladder_morpholo1.19261372
62MP0001661_extended_life_span1.19254325
63MP0002420_abnormal_adaptive_immunity1.17763115
64MP0002233_abnormal_nose_morphology1.16895816
65MP0009333_abnormal_splenocyte_physiolog1.16831097
66MP0005257_abnormal_intraocular_pressure1.16391744
67MP0005646_abnormal_pituitary_gland1.14926207
68MP0001819_abnormal_immune_cell1.14117408
69MP0008961_abnormal_basal_metabolism1.13923528
70MP0004185_abnormal_adipocyte_glucose1.13254356
71MP0005174_abnormal_tail_pigmentation1.12966463
72MP0002557_abnormal_social/conspecific_i1.12562392
73MP0003300_gastrointestinal_ulcer1.10905613
74MP0000015_abnormal_ear_pigmentation1.10572457
75MP0003866_abnormal_defecation1.09695055
76MP0002452_abnormal_antigen_presenting1.09024623
77MP0005377_hearing/vestibular/ear_phenot1.08260785
78MP0003878_abnormal_ear_physiology1.08260785
79MP0008995_early_reproductive_senescence1.08174064
80MP0001879_abnormal_lymphatic_vessel1.06238001
81MP0003077_abnormal_cell_cycle1.04000315
82MP0009764_decreased_sensitivity_to1.02801247
83MP0002006_tumorigenesis1.02371068
84MP0001486_abnormal_startle_reflex1.01816461
85MP0002019_abnormal_tumor_incidence1.00597989
86MP0004484_altered_response_of1.00169270
87MP0002882_abnormal_neuron_morphology0.99928928
88MP0000003_abnormal_adipose_tissue0.99127192
89MP0005076_abnormal_cell_differentiation0.97779180
90MP0000230_abnormal_systemic_arterial0.93209613
91MP0010094_abnormal_chromosome_stability0.91695374
92MP0000313_abnormal_cell_death0.90895776
93MP0002909_abnormal_adrenal_gland0.90779981
94MP0003252_abnormal_bile_duct0.89450012
95MP0003111_abnormal_nucleus_morphology0.88814819
96MP0005647_abnormal_sex_gland0.88283605
97MP0002653_abnormal_ependyma_morphology0.86469171
98MP0000490_abnormal_crypts_of0.84593026
99MP0010352_gastrointestinal_tract_polyps0.84310967
100MP0009697_abnormal_copulation0.84284050
101MP0002734_abnormal_mechanical_nocicepti0.84115552
102MP0002419_abnormal_innate_immunity0.83170930
103MP0005167_abnormal_blood-brain_barrier0.83087651
104MP0005389_reproductive_system_phenotype0.81470838
105MP0008932_abnormal_embryonic_tissue0.79739915
106MP0002638_abnormal_pupillary_reflex0.77271257
107MP0002938_white_spotting0.76904893
108MP0000778_abnormal_nervous_system0.76651687
109MP0002152_abnormal_brain_morphology0.76025824
110MP0005025_abnormal_response_to0.75907108
111MP0002272_abnormal_nervous_system0.75645073
112MP0000249_abnormal_blood_vessel0.75432746
113MP0009763_increased_sensitivity_to0.75151541
114MP0005535_abnormal_body_temperature0.74942369
115MP0002896_abnormal_bone_mineralization0.74508027
116MP0002086_abnormal_extraembryonic_tissu0.73568073
117MP0005409_darkened_coat_color0.72634649
118MP0003453_abnormal_keratinocyte_physiol0.71944691
119MP0003566_abnormal_cell_adhesion0.71740319
120MP0002229_neurodegeneration0.71553592
121MP0001191_abnormal_skin_condition0.71163645
122MP0002822_catalepsy0.71102546
123MP0000598_abnormal_liver_morphology0.70559368
124MP0004811_abnormal_neuron_physiology0.70474126
125MP0003221_abnormal_cardiomyocyte_apopto0.69935632
126MP0001790_abnormal_immune_system0.69732649
127MP0005387_immune_system_phenotype0.69732649
128MP0001845_abnormal_inflammatory_respons0.69256316
129MP0005075_abnormal_melanosome_morpholog0.69166027
130MP0002148_abnormal_hypersensitivity_rea0.68822600
131MP0000358_abnormal_cell_content/0.67547869
132MP0000383_abnormal_hair_follicle0.66971347
133MP0004742_abnormal_vestibular_system0.65494224
134MP0001784_abnormal_fluid_regulation0.65284208
135MP0005187_abnormal_penis_morphology0.65195969
136MP0000343_altered_response_to0.64997990
137MP0003693_abnormal_embryo_hatching0.64870640
138MP0005195_abnormal_posterior_eye0.63749056
139MP0003941_abnormal_skin_development0.63696683
140MP0000631_abnormal_neuroendocrine_gland0.63577822
141MP0005058_abnormal_lysosome_morphology0.63230464
142MP0003763_abnormal_thymus_physiology0.63219846
143MP0003634_abnormal_glial_cell0.63130668
144MP0000026_abnormal_inner_ear0.61119983
145MP0001188_hyperpigmentation0.58559791
146MP0000538_abnormal_urinary_bladder0.57199926
147MP0002102_abnormal_ear_morphology0.56474501
148MP0003635_abnormal_synaptic_transmissio0.55939030
149MP0002092_abnormal_eye_morphology0.54967844
150MP0001270_distended_abdomen0.53455036
151MP0006082_CNS_inflammation0.51922650
152MP0001963_abnormal_hearing_physiology0.51852238
153MP0004858_abnormal_nervous_system0.50887824
154MP0003075_altered_response_to0.50790174
155MP0005220_abnormal_exocrine_pancreas0.50708059
156MP0002009_preneoplasia0.50171696
157MP0002063_abnormal_learning/memory/cond0.47314853
158MP0005423_abnormal_somatic_nervous0.46559007
159MP0003861_abnormal_nervous_system0.45268398
160MP0005165_increased_susceptibility_to0.44229678
161MP0001944_abnormal_pancreas_morphology0.43985534
162MP0003633_abnormal_nervous_system0.43413724
163MP0006276_abnormal_autonomic_nervous0.42369388
164MP0005584_abnormal_enzyme/coenzyme_acti0.41715918
165MP0000569_abnormal_digit_pigmentation0.38859136
166MP0008875_abnormal_xenobiotic_pharmacok0.37432783
167MP0004147_increased_porphyrin_level0.37217027
168MP0010386_abnormal_urinary_bladder0.37037470
169MP0003942_abnormal_urinary_system0.36645901
170MP0003183_abnormal_peptide_metabolism0.35729089
171MP0006035_abnormal_mitochondrial_morpho0.34809265
172MP0002067_abnormal_sensory_capabilities0.33749942
173MP0006036_abnormal_mitochondrial_physio0.33340251
174MP0004130_abnormal_muscle_cell0.32281067
175MP0005310_abnormal_salivary_gland0.31606052
176MP0006054_spinal_hemorrhage0.31421846
177MP0002572_abnormal_emotion/affect_behav0.30459567
178MP0001286_abnormal_eye_development0.29600674
179MP0001502_abnormal_circadian_rhythm0.29309957
180MP0003879_abnormal_hair_cell0.29053323
181MP0005391_vision/eye_phenotype0.28978166
182MP0003880_abnormal_central_pattern0.27381256
183MP0002210_abnormal_sex_determination0.26897383
184MP0003195_calcinosis0.26688492
185MP0009765_abnormal_xenobiotic_induced0.26037722
186MP0002082_postnatal_lethality0.25634994
187MP0010770_preweaning_lethality0.25634994
188MP0002081_perinatal_lethality0.25219068

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.22484770
2Prolonged bleeding time (HP:0003010)8.13016818
3Retinal dysplasia (HP:0007973)6.87693597
4Increased mean platelet volume (HP:0011877)6.56484594
5Abnormal respiratory motile cilium physiology (HP:0012261)6.43471609
6Abnormal platelet volume (HP:0011876)6.40040089
7Petechiae (HP:0000967)6.35759555
8Abnormality of macular pigmentation (HP:0008002)6.22895972
9Menorrhagia (HP:0000132)6.10033380
10Rhinitis (HP:0012384)5.82485363
11Chronic bronchitis (HP:0004469)5.62760056
12Epistaxis (HP:0000421)5.55473166
13Bifid tongue (HP:0010297)5.17067040
14Gingival bleeding (HP:0000225)5.04079982
15Abnormality of midbrain morphology (HP:0002418)4.94299077
16Molar tooth sign on MRI (HP:0002419)4.94299077
17Limb dystonia (HP:0002451)4.88680068
18Purpura (HP:0000979)4.84239056
19Abnormal ciliary motility (HP:0012262)4.80588103
20Abnormal respiratory epithelium morphology (HP:0012253)4.77730064
21Abnormal respiratory motile cilium morphology (HP:0005938)4.77730064
22Bony spicule pigmentary retinopathy (HP:0007737)4.50608779
23Abnormality of the fingertips (HP:0001211)4.38052110
24Palpitations (HP:0001962)4.27222723
25Impaired platelet aggregation (HP:0003540)4.26240943
26Abnormal platelet function (HP:0011869)4.26240943
27Hypothermia (HP:0002045)4.15942707
28Chronic hepatic failure (HP:0100626)4.07243232
29Abolished electroretinogram (ERG) (HP:0000550)3.82659093
30Central scotoma (HP:0000603)3.70035506
31Hypochromic microcytic anemia (HP:0004840)3.69357178
32Congenital primary aphakia (HP:0007707)3.64990729
33Colitis (HP:0002583)3.62687440
34Gait imbalance (HP:0002141)3.62424481
35Spontaneous hematomas (HP:0007420)3.59000150
36Dynein arm defect of respiratory motile cilia (HP:0012255)3.58419787
37Absent/shortened dynein arms (HP:0200106)3.58419787
38Nephrogenic diabetes insipidus (HP:0009806)3.56947830
39Medial flaring of the eyebrow (HP:0010747)3.52731462
40Dyschromatopsia (HP:0007641)3.52053518
41Acanthocytosis (HP:0001927)3.51200211
42Dysphonia (HP:0001618)3.50157297
43Febrile seizures (HP:0002373)3.45601374
44Abnormality of the heme biosynthetic pathway (HP:0010472)3.37897814
45Anosmia (HP:0000458)3.35840391
46Bronchiectasis (HP:0002110)3.31142746
47Acute lymphatic leukemia (HP:0006721)3.25019288
48Atonic seizures (HP:0010819)3.21308283
49Abnormality of dentin (HP:0010299)3.20793532
50Nephronophthisis (HP:0000090)3.19957997
51Poikilocytosis (HP:0004447)3.16988943
52Papillary thyroid carcinoma (HP:0002895)3.09335979
53Elevated erythrocyte sedimentation rate (HP:0003565)3.06455732
54Syncope (HP:0001279)2.99585731
55Postaxial hand polydactyly (HP:0001162)2.98222138
56Autoimmune hemolytic anemia (HP:0001890)2.94055367
57True hermaphroditism (HP:0010459)2.93849460
58IgM deficiency (HP:0002850)2.92648200
59Pancreatic fibrosis (HP:0100732)2.86375088
60Vaginal atresia (HP:0000148)2.83708261
61Constricted visual fields (HP:0001133)2.83495008
62Inflammation of the large intestine (HP:0002037)2.79050957
63Genital tract atresia (HP:0001827)2.70012745
64Tinnitus (HP:0000360)2.68437941
65Pancreatic cysts (HP:0001737)2.65004377
66Absent rod-and cone-mediated responses on ERG (HP:0007688)2.64844055
67Poor coordination (HP:0002370)2.61150423
68Short nail (HP:0001799)2.58156662
69Cystic liver disease (HP:0006706)2.57308639
70Nasal polyposis (HP:0100582)2.56966371
71Paralysis (HP:0003470)2.56611299
72Occipital encephalocele (HP:0002085)2.55780012
73Gastrointestinal inflammation (HP:0004386)2.54329618
74Abnormality of the renal medulla (HP:0100957)2.53197151
75Abnormality of sodium homeostasis (HP:0010931)2.53111315
76Abnormal rod and cone electroretinograms (HP:0008323)2.52885472
77Erythema (HP:0010783)2.49056177
78Tubulointerstitial nephritis (HP:0001970)2.47529008
79Large eyes (HP:0001090)2.46020602
80Oculomotor apraxia (HP:0000657)2.44256336
81Acute myeloid leukemia (HP:0004808)2.42314915
82Xerostomia (HP:0000217)2.41853680
83Aplasia/Hypoplasia of the lens (HP:0008063)2.41252154
84IgA deficiency (HP:0002720)2.37139310
85Arterial thrombosis (HP:0004420)2.36140847
86Recurrent sinusitis (HP:0011108)2.35358884
87Absent eyebrow (HP:0002223)2.33933212
88Abnormality of iron homeostasis (HP:0011031)2.32352706
89Hyperlipoproteinemia (HP:0010980)2.31720210
90Neonatal hypoglycemia (HP:0001998)2.30457426
91Recurrent otitis media (HP:0000403)2.29854974
92Bruising susceptibility (HP:0000978)2.28627084
93Ankyloglossia (HP:0010296)2.25490780
94Vacuolated lymphocytes (HP:0001922)2.23713262
95Abnormality of transition element cation homeostasis (HP:0011030)2.22415523
96Cellulitis (HP:0100658)2.22381587
97Retinitis pigmentosa (HP:0000510)2.21943168
98Interstitial pulmonary disease (HP:0006530)2.21823153
99Bronchitis (HP:0012387)2.21156331
100Torticollis (HP:0000473)2.20640746
101Thyroid carcinoma (HP:0002890)2.19377472
102Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.17966307
103Absence seizures (HP:0002121)2.15504479
104Abnormality of the dental pulp (HP:0006479)2.14044045
105Distal lower limb amyotrophy (HP:0008944)2.12936970
106Prominent nose (HP:0000448)2.12209801
107Prolonged QT interval (HP:0001657)2.05406884
108Furrowed tongue (HP:0000221)2.05318354
109Abnormality of permanent molar morphology (HP:0011071)2.04176208
110Abnormality of the dental root (HP:0006486)2.04176208
111Taurodontia (HP:0000679)2.04176208
112Increased serum ferritin (HP:0003281)2.03310100
113Congenital hepatic fibrosis (HP:0002612)2.01177832
114Bile duct proliferation (HP:0001408)1.98753404
115Abnormal biliary tract physiology (HP:0012439)1.98753404
116Myelodysplasia (HP:0002863)1.98630977
117Microcytic anemia (HP:0001935)1.98435962
118Chronic sinusitis (HP:0011109)1.98344074
119Clubbing of toes (HP:0100760)1.97604534
120Abnormality of the nasal mucosa (HP:0000433)1.97357787
121Sudden death (HP:0001699)1.97140397
122Disinhibition (HP:0000734)1.95089820
123Median cleft lip (HP:0000161)1.95041283
124Optic neuritis (HP:0100653)1.94179058
125Retrobulbar optic neuritis (HP:0100654)1.94179058
126Chest pain (HP:0100749)1.93490005
127Septate vagina (HP:0001153)1.90950459
128Thrombocytosis (HP:0001894)1.90237438
129Renal hypoplasia (HP:0000089)1.89367935
130Scotoma (HP:0000575)1.88142344
131Abnormality of molar morphology (HP:0011070)1.87958622
132Abnormality of molar (HP:0011077)1.87958622
133Restlessness (HP:0000711)1.87449418
134Abnormality of the prostate (HP:0008775)1.86906943
135Subaortic stenosis (HP:0001682)1.86547963
136Abnormality of the left ventricular outflow tract (HP:0011103)1.86547963
137Abnormality of alanine metabolism (HP:0010916)1.85611853
138Hyperalaninemia (HP:0003348)1.85611853
139Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85611853
140Craniofacial dystonia (HP:0012179)1.84296702
141Agitation (HP:0000713)1.83135046
142Diminished motivation (HP:0000745)1.82892106
143Left ventricular hypertrophy (HP:0001712)1.82773432
144Bradycardia (HP:0001662)1.81030155
145Abnormality of the vasculature of the conjunctiva (HP:0008054)1.80059463
146Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80047029
147Lymphedema (HP:0001004)1.80039001
148Abnormality of the common coagulation pathway (HP:0010990)1.79103548
149Increased density of long bones (HP:0006392)1.77203100
150Conjunctival telangiectasia (HP:0000524)1.77031252
151Panhypogammaglobulinemia (HP:0003139)1.76584356
152Aganglionic megacolon (HP:0002251)1.76547671
153Uterine leiomyosarcoma (HP:0002891)1.76285481
154Leiomyosarcoma (HP:0100243)1.76285481
155Clumsiness (HP:0002312)1.76102472
156Severe visual impairment (HP:0001141)1.75414706
157Viral hepatitis (HP:0006562)1.75097090
158Narrow forehead (HP:0000341)1.74794766
159Conjugated hyperbilirubinemia (HP:0002908)1.74212033
160Focal dystonia (HP:0004373)1.73730224
161Abnormality of the columella (HP:0009929)1.72709173
162Hyperglycinemia (HP:0002154)1.71868596
163Sandal gap (HP:0001852)1.71274285
164Apathy (HP:0000741)1.70701396
165Decreased testicular size (HP:0008734)1.69090775
166Conjunctival hamartoma (HP:0100780)1.68617020
167Chromsome breakage (HP:0040012)1.68489972
168Encephalitis (HP:0002383)1.68158104
169Chronic otitis media (HP:0000389)1.67882370
170Reticulocytosis (HP:0001923)1.67754149
171Deep philtrum (HP:0002002)1.67433404
172Abnormality of oral frenula (HP:0000190)1.66791505
173Recurrent viral infections (HP:0004429)1.66656226
174Insidious onset (HP:0003587)1.66319624
175Termporal pattern (HP:0011008)1.66319624
176Bladder neoplasm (HP:0009725)1.64351906
177Bladder carcinoma (HP:0002862)1.64351906
178Menstrual irregularities (HP:0000858)1.64141375
179Acute hepatic failure (HP:0006554)1.62279729
180Testicular neoplasm (HP:0010788)1.61808244
181Eczematoid dermatitis (HP:0000976)1.61790845
182Abnormality of T cell physiology (HP:0011840)1.61572925
183Granulocytopenia (HP:0001913)1.61542523
184Polycythemia (HP:0001901)1.61508101
185Spontaneous abortion (HP:0005268)1.61065413
186Dysmetric saccades (HP:0000641)1.60958046
187Transitional cell carcinoma of the bladder (HP:0006740)1.58443198
188Thyroiditis (HP:0100646)1.58287038
189Meningitis (HP:0001287)1.58252584
190Fair hair (HP:0002286)1.58000916
191Deformed sella turcica (HP:0002681)1.56935099
192Hypoplastic iliac wings (HP:0002866)1.54676075
193Flat occiput (HP:0005469)1.54550926
194Hyperthyroidism (HP:0000836)1.54061547
195Lymphoma (HP:0002665)1.52053536
196Abnormal large intestine physiology (HP:0012700)1.51983150
197Hypochromic anemia (HP:0001931)1.51733395

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK18.32445779
2ZAK8.09441225
3ERBB34.92989771
4PHKG14.02375921
5PHKG24.02375921
6MAPK153.87372431
7VRK13.84652101
8MAPKAPK33.74665177
9ARAF3.68084788
10PAK33.34282956
11RPS6KA53.20021762
12EEF2K3.08230974
13NUAK12.50020047
14FRK2.41650094
15RIPK42.29680229
16CAMK1G2.26634675
17CAMK2D1.97816809
18BTK1.93980073
19STK41.93264781
20DAPK31.88407365
21STK241.81627746
22CAMK2B1.79618043
23TEC1.75469254
24DAPK21.71897649
25SCYL21.71215602
26PIM21.64852205
27MAP3K101.62912916
28MAP2K31.49904415
29CAMK2G1.48255954
30PIM11.46339019
31CAMK1D1.45596419
32CAMKK21.44635385
33HIPK21.43013219
34SYK1.42124933
35ICK1.39413554
36STK38L1.37907224
37AKT31.33533189
38CSNK1A1L1.33505217
39BRAF1.30932122
40DYRK1A1.27858812
41PIK3CG1.27438273
42DYRK1B1.26817352
43TGFBR21.26154648
44RPS6KA21.25116416
45BLK1.24408805
46TAOK31.21649093
47DAPK11.16770612
48AURKA1.14770892
49CDK121.10269987
50PKN21.06175107
51EPHA31.04839920
52HCK1.01219062
53FGFR30.99756682
54DYRK30.98087935
55BMX0.97651247
56TRIB30.95783199
57MAP3K20.94506386
58CSNK1G30.93906065
59TRPM70.88795328
60GRK60.87185452
61PNCK0.86626505
62CDK90.85629990
63ILK0.83173969
64JAK20.82637776
65SRPK10.82247704
66MST40.82099393
67FES0.75732697
68CSF1R0.75246552
69CSNK1G20.74779666
70STK160.73962484
71SIK10.73787045
72IKBKB0.73656367
73PRKCG0.72983736
74CSNK1G10.71647680
75IRAK10.69826842
76RIPK10.68842409
77MAPK110.67942201
78MAPK130.67647250
79NLK0.66898849
80BRSK20.66053602
81CAMKK10.65016722
82CHEK20.63441843
83MAPKAPK20.62778320
84FLT30.61550783
85ZAP700.61137475
86BMPR20.60418704
87SIK20.59554932
88PDK10.59298208
89TNK20.59005172
90STK380.58525189
91INSRR0.58506164
92PRKCQ0.57924099
93SGK2230.57399630
94SGK4940.57399630
95AURKB0.57236180
96TXK0.56746919
97MAP2K10.56745760
98MAP3K60.56661449
99LYN0.56482895
100RET0.56471923
101MARK30.55907663
102PRKAA20.55621405
103STK390.54718174
104MAPK120.52620638
105KSR20.51391361
106CHUK0.50112243
107MAP3K40.49503628
108TTN0.48752857
109MAP2K70.48108700
110EIF2AK10.46780651
111CDK60.46507059
112TTK0.46262827
113PAK10.45617844
114SGK20.44834827
115MARK20.44047403
116ERBB20.43274106
117PDPK10.43217254
118MKNK20.42580060
119RPS6KL10.41703727
120RPS6KC10.41703727
121MAP3K50.40780786
122PRKAA10.40150614
123BRD40.38444442
124MAP2K40.37663379
125IRAK20.37267355
126CCNB10.36905964
127STK30.36698469
128IKBKE0.36135080
129RPS6KA60.36119040
130MAPKAPK50.35967231
131CDC70.35299112
132KSR10.34517888
133CAMK40.34209781
134FYN0.33723664
135RPS6KB20.33191675
136ITK0.32874821
137MAP3K70.31245536
138AKT20.31060722
139NTRK20.30667815
140SGK30.30600123
141MAP3K80.30218025
142CAMK2A0.29969421
143RPS6KA10.29378397
144RAF10.29213474
145TBK10.29053705
146PRPF4B0.28243491
147IRAK40.28060770
148RPS6KA40.28029611
149PRKD10.27589111
150MAP2K20.26796147
151MAP3K10.26664864
152STK110.26528706
153FGFR20.25972683
154ATR0.25153888
155MYLK0.25122185
156MAP3K140.24468281
157MAP3K30.24017695
158PKN10.23804927
159PRKACG0.23322302
160LMTK20.22684008
161TNIK0.22441585
162PTK2B0.22107369
163MTOR0.21872566
164INSR0.20696546
165EGFR0.19650508

Predicted pathways (KEGG)

RankGene SetZ-score
1* Viral carcinogenesis_Homo sapiens_hsa052033.63613818
2Phototransduction_Homo sapiens_hsa047443.32861047
3Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.77564266
4Transcriptional misregulation in cancer_Homo sapiens_hsa052022.16157348
5Olfactory transduction_Homo sapiens_hsa0474012.2966237
6Circadian entrainment_Homo sapiens_hsa047131.73090181
7Taste transduction_Homo sapiens_hsa047421.66955121
8Insulin secretion_Homo sapiens_hsa049111.65746553
9Morphine addiction_Homo sapiens_hsa050321.60498632
10Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.56661471
11Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49743680
12cAMP signaling pathway_Homo sapiens_hsa040241.46713468
13Dopaminergic synapse_Homo sapiens_hsa047281.43862558
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.43134076
15Non-small cell lung cancer_Homo sapiens_hsa052231.40559141
16Gastric acid secretion_Homo sapiens_hsa049711.36455997
17Salivary secretion_Homo sapiens_hsa049701.25785860
18Fatty acid biosynthesis_Homo sapiens_hsa000611.25312553
19Ovarian steroidogenesis_Homo sapiens_hsa049131.24489177
20GABAergic synapse_Homo sapiens_hsa047271.21840292
21Cholinergic synapse_Homo sapiens_hsa047251.18174744
22Vibrio cholerae infection_Homo sapiens_hsa051101.16665852
23* Alcoholism_Homo sapiens_hsa050341.12795932
24Acute myeloid leukemia_Homo sapiens_hsa052211.12499199
25cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12186243
26Glutamatergic synapse_Homo sapiens_hsa047241.11569345
27ABC transporters_Homo sapiens_hsa020101.07748788
28Thyroid hormone synthesis_Homo sapiens_hsa049181.07186739
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05560642
30Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03395186
31Bile secretion_Homo sapiens_hsa049760.98023625
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97889054
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94779291
34Leishmaniasis_Homo sapiens_hsa051400.92918323
35Histidine metabolism_Homo sapiens_hsa003400.92005430
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89432484
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83670431
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82238164
39Amphetamine addiction_Homo sapiens_hsa050310.81109025
40GnRH signaling pathway_Homo sapiens_hsa049120.80570899
41Glucagon signaling pathway_Homo sapiens_hsa049220.80144636
42Calcium signaling pathway_Homo sapiens_hsa040200.79440556
43beta-Alanine metabolism_Homo sapiens_hsa004100.78905289
44Osteoclast differentiation_Homo sapiens_hsa043800.78131773
45Hematopoietic cell lineage_Homo sapiens_hsa046400.77754283
46Sphingolipid metabolism_Homo sapiens_hsa006000.74994783
47Renin secretion_Homo sapiens_hsa049240.74981091
48Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73929785
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73524194
50Melanogenesis_Homo sapiens_hsa049160.72301093
51N-Glycan biosynthesis_Homo sapiens_hsa005100.72014843
52VEGF signaling pathway_Homo sapiens_hsa043700.70996077
53Inositol phosphate metabolism_Homo sapiens_hsa005620.70332924
54Choline metabolism in cancer_Homo sapiens_hsa052310.68748578
55Estrogen signaling pathway_Homo sapiens_hsa049150.68438182
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.67496566
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66240656
58mTOR signaling pathway_Homo sapiens_hsa041500.65831088
59Nitrogen metabolism_Homo sapiens_hsa009100.64186845
60p53 signaling pathway_Homo sapiens_hsa041150.63912391
61ErbB signaling pathway_Homo sapiens_hsa040120.63025501
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60996119
63Propanoate metabolism_Homo sapiens_hsa006400.59100074
64Synaptic vesicle cycle_Homo sapiens_hsa047210.58890638
65T cell receptor signaling pathway_Homo sapiens_hsa046600.57393184
66Oxytocin signaling pathway_Homo sapiens_hsa049210.57209732
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57147767
68Other glycan degradation_Homo sapiens_hsa005110.57067863
69Renal cell carcinoma_Homo sapiens_hsa052110.56166593
70Purine metabolism_Homo sapiens_hsa002300.53765041
71Thyroid cancer_Homo sapiens_hsa052160.53684972
72Prolactin signaling pathway_Homo sapiens_hsa049170.53475774
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.53370012
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53338955
75Pancreatic cancer_Homo sapiens_hsa052120.51708829
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51059407
77Pancreatic secretion_Homo sapiens_hsa049720.50526735
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.50473987
79Insulin signaling pathway_Homo sapiens_hsa049100.49400350
80Long-term potentiation_Homo sapiens_hsa047200.48764282
81Influenza A_Homo sapiens_hsa051640.48097186
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.47823585
83Long-term depression_Homo sapiens_hsa047300.47822026
84Herpes simplex infection_Homo sapiens_hsa051680.46692442
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46610431
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46178194
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.45876166
88Prostate cancer_Homo sapiens_hsa052150.45848194
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45798706
90Measles_Homo sapiens_hsa051620.45737950
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.45611806
92Arachidonic acid metabolism_Homo sapiens_hsa005900.45001067
93* Systemic lupus erythematosus_Homo sapiens_hsa053220.44636879
94Serotonergic synapse_Homo sapiens_hsa047260.43753516
95Small cell lung cancer_Homo sapiens_hsa052220.43615293
96Chemokine signaling pathway_Homo sapiens_hsa040620.43094320
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42835469
98Apoptosis_Homo sapiens_hsa042100.42414538
99Gap junction_Homo sapiens_hsa045400.42334764
100Parkinsons disease_Homo sapiens_hsa050120.41820477
101Asthma_Homo sapiens_hsa053100.41794388
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41667239
103Tuberculosis_Homo sapiens_hsa051520.41623979
104Dilated cardiomyopathy_Homo sapiens_hsa054140.41341557
105Toxoplasmosis_Homo sapiens_hsa051450.40965810
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40245286
107Graft-versus-host disease_Homo sapiens_hsa053320.39922509
108Allograft rejection_Homo sapiens_hsa053300.39146479
109Melanoma_Homo sapiens_hsa052180.38994846
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38284692
111Alzheimers disease_Homo sapiens_hsa050100.38088884
112Staphylococcus aureus infection_Homo sapiens_hsa051500.37943422
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.37416688
114Oocyte meiosis_Homo sapiens_hsa041140.37185491
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36910868
116Dorso-ventral axis formation_Homo sapiens_hsa043200.36860200
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35913291
118Bladder cancer_Homo sapiens_hsa052190.35234889
119Legionellosis_Homo sapiens_hsa051340.33771785
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.33636517
121Autoimmune thyroid disease_Homo sapiens_hsa053200.32830248
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32513278
123Primary immunodeficiency_Homo sapiens_hsa053400.32401281
124Glioma_Homo sapiens_hsa052140.32054422
125Notch signaling pathway_Homo sapiens_hsa043300.31935028
126Ras signaling pathway_Homo sapiens_hsa040140.29111091
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28134832
128TNF signaling pathway_Homo sapiens_hsa046680.27815577
129Fatty acid degradation_Homo sapiens_hsa000710.27151383
130Rap1 signaling pathway_Homo sapiens_hsa040150.26748164
131Chronic myeloid leukemia_Homo sapiens_hsa052200.25963858
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25820942
133Colorectal cancer_Homo sapiens_hsa052100.25362121
134Cell cycle_Homo sapiens_hsa041100.24536913
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.24145714
136HTLV-I infection_Homo sapiens_hsa051660.23787714
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.23594301
138Insulin resistance_Homo sapiens_hsa049310.22912137
139Cardiac muscle contraction_Homo sapiens_hsa042600.22420496
140HIF-1 signaling pathway_Homo sapiens_hsa040660.21842214
141Regulation of autophagy_Homo sapiens_hsa041400.21670351
142MAPK signaling pathway_Homo sapiens_hsa040100.21416967
143Hepatitis C_Homo sapiens_hsa051600.20508240
144Fanconi anemia pathway_Homo sapiens_hsa034600.20409729
145Shigellosis_Homo sapiens_hsa051310.20342633
146FoxO signaling pathway_Homo sapiens_hsa040680.19480767
147DNA replication_Homo sapiens_hsa030300.19440893
148Viral myocarditis_Homo sapiens_hsa054160.18878484
149MicroRNAs in cancer_Homo sapiens_hsa052060.18558447
150Starch and sucrose metabolism_Homo sapiens_hsa005000.18428377
151Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18406345
152Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17781612
153Pyruvate metabolism_Homo sapiens_hsa006200.17631189
154B cell receptor signaling pathway_Homo sapiens_hsa046620.17365850
155Type II diabetes mellitus_Homo sapiens_hsa049300.15752057
156Sulfur metabolism_Homo sapiens_hsa009200.13807278
157Hepatitis B_Homo sapiens_hsa051610.13170545
158AMPK signaling pathway_Homo sapiens_hsa041520.12441432
159Endometrial cancer_Homo sapiens_hsa052130.12150095
160Amoebiasis_Homo sapiens_hsa051460.11812928
161Axon guidance_Homo sapiens_hsa043600.10954566
162Collecting duct acid secretion_Homo sapiens_hsa049660.10898997
163Huntingtons disease_Homo sapiens_hsa050160.10342059
164Platelet activation_Homo sapiens_hsa046110.10024733

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