HIST2H2BF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and is found in a histone cluster on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antibacterial humoral response (GO:0019731)9.64545186
2organ or tissue specific immune response (GO:0002251)9.24539400
3antimicrobial humoral response (GO:0019730)8.85280785
4DNA replication-dependent nucleosome assembly (GO:0006335)8.68554421
5DNA replication-dependent nucleosome organization (GO:0034723)8.68554421
6nucleosome assembly (GO:0006334)8.13390800
7chromatin assembly (GO:0031497)7.97241564
8nuclear pore complex assembly (GO:0051292)7.25686685
9protein-DNA complex assembly (GO:0065004)6.91103976
10nucleosome organization (GO:0034728)6.82276107
11nuclear pore organization (GO:0006999)6.49430484
12protein-DNA complex subunit organization (GO:0071824)5.97189525
13regulation of histone H3-K9 methylation (GO:0051570)5.65678093
14pore complex assembly (GO:0046931)5.48950548
15chromatin assembly or disassembly (GO:0006333)5.37493774
16DNA unwinding involved in DNA replication (GO:0006268)5.37296517
17DNA replication initiation (GO:0006270)4.99962287
18DNA strand elongation involved in DNA replication (GO:0006271)4.81502500
19DNA strand elongation (GO:0022616)4.63898212
20protein localization to chromosome, centromeric region (GO:0071459)4.37281860
21mitotic chromosome condensation (GO:0007076)4.33407213
22defense response to Gram-positive bacterium (GO:0050830)4.26427301
23telomere maintenance via semi-conservative replication (GO:0032201)4.24027498
24mitotic sister chromatid segregation (GO:0000070)4.01879750
25sister chromatid segregation (GO:0000819)3.98296981
26negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.94144208
27telomere maintenance via recombination (GO:0000722)3.85021091
28DNA duplex unwinding (GO:0032508)3.83532205
29DNA geometric change (GO:0032392)3.69655365
30V(D)J recombination (GO:0033151)3.67131699
31mitotic recombination (GO:0006312)3.61570197
32viral mRNA export from host cell nucleus (GO:0046784)3.60659451
33mitotic nuclear envelope disassembly (GO:0007077)3.47481526
34regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.44044789
35mitotic sister chromatid cohesion (GO:0007064)3.39236763
36DNA synthesis involved in DNA repair (GO:0000731)3.37686151
37positive regulation of mitotic sister chromatid separation (GO:1901970)3.35124854
38positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.35124854
39positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.35124854
40regulation of centrosome cycle (GO:0046605)3.24167044
41membrane disassembly (GO:0030397)3.24143100
42nuclear envelope disassembly (GO:0051081)3.24143100
43regulation of megakaryocyte differentiation (GO:0045652)3.24112245
44regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.22144113
45CENP-A containing nucleosome assembly (GO:0034080)3.21919191
46positive regulation of chromosome segregation (GO:0051984)3.20162692
47histone lysine demethylation (GO:0070076)3.20019117
48mature B cell differentiation involved in immune response (GO:0002313)3.15859336
49histone demethylation (GO:0016577)3.15694042
50chromatin remodeling at centromere (GO:0031055)3.15593008
51B cell receptor signaling pathway (GO:0050853)3.12079841
52regulation of translational fidelity (GO:0006450)3.10110881
53DNA conformation change (GO:0071103)3.07958429
54telomere organization (GO:0032200)3.06198709
55protein localization to kinetochore (GO:0034501)3.05212883
56telomere maintenance (GO:0000723)3.04373415
57regulation of sister chromatid cohesion (GO:0007063)3.03779223
58regulation of gene silencing (GO:0060968)3.00214186
59peptidyl-lysine dimethylation (GO:0018027)2.99727413
60positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.98354350
61regulation of centrosome duplication (GO:0010824)2.96969742
62replicative senescence (GO:0090399)2.94844912
63negative regulation of DNA repair (GO:0045738)2.91164779
64embryonic process involved in female pregnancy (GO:0060136)2.86039725
65histone H3-K36 demethylation (GO:0070544)2.84403676
66negative regulation of B cell apoptotic process (GO:0002903)2.83749389
67double-strand break repair via nonhomologous end joining (GO:0006303)2.83450795
68non-recombinational repair (GO:0000726)2.83450795
69spliceosomal tri-snRNP complex assembly (GO:0000244)2.81457977
70histone phosphorylation (GO:0016572)2.81364542
71protein demethylation (GO:0006482)2.80739452
72protein dealkylation (GO:0008214)2.80739452
73DNA replication checkpoint (GO:0000076)2.75801167
74nucleotide-excision repair, DNA gap filling (GO:0006297)2.75746638
75regulation of chromosome segregation (GO:0051983)2.74799210
76meiotic chromosome segregation (GO:0045132)2.73213840
77B cell proliferation (GO:0042100)2.73205886
78maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.71625191
79mRNA cleavage (GO:0006379)2.71194427
80chromosome condensation (GO:0030261)2.69829303
81telomere maintenance via telomere lengthening (GO:0010833)2.69797833
82mitochondrial DNA metabolic process (GO:0032042)2.69452658
83rRNA transcription (GO:0009303)2.68853323
84mature B cell differentiation (GO:0002335)2.68423939
85regulation of mammary gland epithelial cell proliferation (GO:0033599)2.61785414
86somatic cell DNA recombination (GO:0016444)2.61722928
87somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.61722928
88dosage compensation (GO:0007549)2.61127433
89regulation of RNA export from nucleus (GO:0046831)2.57867137
90translesion synthesis (GO:0019985)2.57020349
91regulation of DNA damage checkpoint (GO:2000001)2.54180262
92nuclear envelope organization (GO:0006998)2.54039940
93positive regulation of DNA-templated transcription, initiation (GO:2000144)2.51935196
94regulation of sister chromatid segregation (GO:0033045)2.51790388
95regulation of mitotic sister chromatid separation (GO:0010965)2.51790388
96regulation of mitotic sister chromatid segregation (GO:0033047)2.51790388
97T cell lineage commitment (GO:0002360)2.51067820
98positive regulation of cell cycle checkpoint (GO:1901978)2.50542439
99innate immune response in mucosa (GO:0002227)12.2495618
100mucosal immune response (GO:0002385)10.0840413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.52710132
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.34095711
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.23974837
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.16512356
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.48377993
6EGR1_23403033_ChIP-Seq_LIVER_Mouse2.81673727
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.66631707
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.55590258
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.49256880
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.22869346
11SOX2_16153702_ChIP-ChIP_HESCs_Human2.18218129
12MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13770399
13POU5F1_16153702_ChIP-ChIP_HESCs_Human2.05588121
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse16.9155495
15RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.86569501
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83163761
17HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.82815706
18CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.73525583
19IRF1_19129219_ChIP-ChIP_H3396_Human1.57162361
20NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50057661
21VDR_21846776_ChIP-Seq_THP-1_Human1.48318186
22ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43347960
23SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.42060993
24MYC_19030024_ChIP-ChIP_MESCs_Mouse1.37939649
25MYC_22102868_ChIP-Seq_BL_Human1.37763195
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37220548
27HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36811361
28ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36043233
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.35298600
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.32931709
31GATA1_22025678_ChIP-Seq_K562_Human1.29263684
32VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26397284
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.25805378
34TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19096614
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18172934
36AR_21909140_ChIP-Seq_LNCAP_Human1.17864494
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17554276
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14851650
39CIITA_25753668_ChIP-Seq_RAJI_Human1.13566518
40VDR_23849224_ChIP-Seq_CD4+_Human1.13555822
41PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11479377
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.09585363
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09212329
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08658150
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07552529
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05017652
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.04987784
48KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04582902
49ETS1_22383799_ChIP-Seq_G1ME_Mouse1.04010992
50NANOG_16153702_ChIP-ChIP_HESCs_Human1.01911733
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00457782
52* MAF_26560356_Chip-Seq_TH1_Human0.98969940
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96470255
54THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94523066
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93438332
56SOX2_18692474_ChIP-Seq_MESCs_Mouse0.91287169
57SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90379670
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89969781
59ELK1_19687146_ChIP-ChIP_HELA_Human0.87492889
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86251108
61MYB_26560356_Chip-Seq_TH1_Human0.84829138
62XRN2_22483619_ChIP-Seq_HELA_Human0.81741933
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80612863
64MYC_18358816_ChIP-ChIP_MESCs_Mouse0.80440342
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.78858323
66MYC_18940864_ChIP-ChIP_HL60_Human0.77103670
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76455434
68IRF8_22096565_ChIP-ChIP_GC-B_Human0.74709278
69FOXP3_21729870_ChIP-Seq_TREG_Human0.72635638
70CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.71753583
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.71741276
72VDR_24763502_ChIP-Seq_THP-1_Human0.71209419
73E2F1_18555785_ChIP-Seq_MESCs_Mouse0.71075043
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.70148423
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.70144732
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.68713727
77KDM5A_27292631_Chip-Seq_BREAST_Human0.68389842
78PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.68004847
79DCP1A_22483619_ChIP-Seq_HELA_Human0.67779466
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.66455441
81ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.66360995
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.65305554
83CREB1_15753290_ChIP-ChIP_HEK293T_Human0.65049022
84MYB_26560356_Chip-Seq_TH2_Human0.64511296
85ZFX_18555785_ChIP-Seq_MESCs_Mouse0.63944393
86MYC_19079543_ChIP-ChIP_MESCs_Mouse0.63208685
87UTX_26944678_Chip-Seq_JUKART_Human0.63108493
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.61037985
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.61015742
90KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.60439686
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.60415757
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.60013928
93NANOG_18555785_ChIP-Seq_MESCs_Mouse0.59509566
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.58298405
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.57964194
96TCF7_22412390_ChIP-Seq_EML_Mouse0.57941895
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.57007353
98SCL_19346495_ChIP-Seq_HPC-7_Human0.56061379
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.54615862
100ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.53387800

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.41313121
2MP0010094_abnormal_chromosome_stability4.82251544
3MP0003111_abnormal_nucleus_morphology3.81154360
4MP0003077_abnormal_cell_cycle3.71501310
5MP0002009_preneoplasia3.44838191
6MP0003693_abnormal_embryo_hatching3.35342854
7MP0010352_gastrointestinal_tract_polyps2.95876782
8MP0004957_abnormal_blastocyst_morpholog2.76380831
9MP0002166_altered_tumor_susceptibility2.74544817
10MP0002396_abnormal_hematopoietic_system2.74022064
11MP0003763_abnormal_thymus_physiology2.69736980
12MP0008007_abnormal_cellular_replicative2.42202096
13MP0010234_abnormal_vibrissa_follicle2.34986876
14MP0000685_abnormal_immune_system2.25641485
15MP0010307_abnormal_tumor_latency2.23366170
16MP0001661_extended_life_span2.16464533
17MP0004808_abnormal_hematopoietic_stem2.13200265
18MP0002006_tumorigenesis2.07301267
19MP0008058_abnormal_DNA_repair2.06062243
20MP0000350_abnormal_cell_proliferation1.93385461
21MP0005076_abnormal_cell_differentiation1.88437036
22MP0001835_abnormal_antigen_presentation1.85916622
23MP0008932_abnormal_embryonic_tissue1.85383796
24MP0009697_abnormal_copulation1.77794877
25MP0004381_abnormal_hair_follicle1.61316023
26MP0004185_abnormal_adipocyte_glucose1.59153335
27MP0000703_abnormal_thymus_morphology1.59043290
28MP0003786_premature_aging1.57311662
29MP0002877_abnormal_melanocyte_morpholog1.56570830
30MP0002398_abnormal_bone_marrow1.55102618
31MP0001800_abnormal_humoral_immune1.47040727
32MP0005645_abnormal_hypothalamus_physiol1.43533537
33MP0002722_abnormal_immune_system1.42222495
34MP0005623_abnormal_meninges_morphology1.40443446
35MP0002019_abnormal_tumor_incidence1.38568773
36MP0000313_abnormal_cell_death1.35502094
37MP0000490_abnormal_crypts_of1.34671156
38MP0000569_abnormal_digit_pigmentation1.33754843
39MP0001730_embryonic_growth_arrest1.28409632
40MP0002086_abnormal_extraembryonic_tissu1.26589554
41MP0000537_abnormal_urethra_morphology1.25061573
42MP0005380_embryogenesis_phenotype1.24582060
43MP0001672_abnormal_embryogenesis/_devel1.24582060
44MP0003984_embryonic_growth_retardation1.21669579
45MP0000689_abnormal_spleen_morphology1.18336095
46MP0002088_abnormal_embryonic_growth/wei1.17798190
47MP0001849_ear_inflammation1.17687933
48MP0005220_abnormal_exocrine_pancreas1.16858030
49MP0002163_abnormal_gland_morphology1.15805784
50MP0002080_prenatal_lethality1.10764498
51MP0005671_abnormal_response_to1.10577688
52MP0001697_abnormal_embryo_size1.08437238
53MP0004233_abnormal_muscle_weight1.06352208
54MP0002429_abnormal_blood_cell1.04367882
55MP0000716_abnormal_immune_system1.02646167
56MP0002160_abnormal_reproductive_system1.02345123
57MP0003705_abnormal_hypodermis_morpholog0.96025851
58MP0002420_abnormal_adaptive_immunity0.95083727
59MP0000733_abnormal_muscle_development0.92085043
60MP0000015_abnormal_ear_pigmentation0.92082211
61MP0002138_abnormal_hepatobiliary_system0.91665481
62MP0001819_abnormal_immune_cell0.91211002
63MP0004947_skin_inflammation0.91161959
64MP0005621_abnormal_cell_physiology0.91061851
65MP0002452_abnormal_antigen_presenting0.89314008
66MP0002084_abnormal_developmental_patter0.88638823
67MP0005000_abnormal_immune_tolerance0.87525990
68MP0005387_immune_system_phenotype0.86986506
69MP0001790_abnormal_immune_system0.86986506
70MP0006035_abnormal_mitochondrial_morpho0.86226959
71MP0005310_abnormal_salivary_gland0.85952608
72MP0009278_abnormal_bone_marrow0.84124004
73MP0000358_abnormal_cell_content/0.84120494
74MP0002085_abnormal_embryonic_tissue0.83597796
75MP0005384_cellular_phenotype0.82803103
76MP0003315_abnormal_perineum_morphology0.81311769
77MP0003300_gastrointestinal_ulcer0.80358303
78MP0002723_abnormal_immune_serum0.79048170
79MP0004197_abnormal_fetal_growth/weight/0.78800176
80MP0005647_abnormal_sex_gland0.78620795
81MP0002092_abnormal_eye_morphology0.78605846
82MP0005451_abnormal_body_composition0.78101201
83MP0003091_abnormal_cell_migration0.73604217
84MP0001346_abnormal_lacrimal_gland0.72250256
85MP0001545_abnormal_hematopoietic_system0.69556950
86MP0005397_hematopoietic_system_phenotyp0.69556950
87MP0003718_maternal_effect0.68196306
88MP0001929_abnormal_gametogenesis0.66218723
89MP0003656_abnormal_erythrocyte_physiolo0.65406376
90MP0001915_intracranial_hemorrhage0.62572113
91MP0001879_abnormal_lymphatic_vessel0.61573551
92MP0003453_abnormal_keratinocyte_physiol0.61405277
93MP0003937_abnormal_limbs/digits/tail_de0.59282952
94MP0002697_abnormal_eye_size0.59090597
95MP0001727_abnormal_embryo_implantation0.59087370
96MP0000477_abnormal_intestine_morphology0.58853669
97MP0005187_abnormal_penis_morphology0.58095155
98MP0002405_respiratory_system_inflammati0.58089424
99MP0009931_abnormal_skin_appearance0.57791165
100MP0003221_abnormal_cardiomyocyte_apopto0.56473138

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.87318701
2IgM deficiency (HP:0002850)5.79934558
3IgA deficiency (HP:0002720)5.58540075
4Chromsome breakage (HP:0040012)5.33929247
5Colitis (HP:0002583)4.78040775
6Abnormality of chromosome stability (HP:0003220)3.44011368
7Gastrointestinal stroma tumor (HP:0100723)3.43860360
8Squamous cell carcinoma (HP:0002860)3.35275901
9Thyroiditis (HP:0100646)3.31107100
10Cellulitis (HP:0100658)3.28102493
11Abnormality of the fingertips (HP:0001211)3.12470695
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.05235553
13Abnormality of the preputium (HP:0100587)2.96542584
14B lymphocytopenia (HP:0010976)2.93808175
15Clubbing of toes (HP:0100760)2.89961308
16Abnormality of the ileum (HP:0001549)2.86175459
17Acute lymphatic leukemia (HP:0006721)2.85753539
18Inflammation of the large intestine (HP:0002037)2.74959573
19Nephroblastoma (Wilms tumor) (HP:0002667)2.73607546
20Recurrent sinusitis (HP:0011108)2.70662717
21Recurrent bronchitis (HP:0002837)2.69476550
22Recurrent viral infections (HP:0004429)2.67500051
23Meckel diverticulum (HP:0002245)2.66929347
24Abnormality of the carotid arteries (HP:0005344)2.65906367
25Medulloblastoma (HP:0002885)2.61145863
26Gastrointestinal inflammation (HP:0004386)2.57819663
27Prominent nose (HP:0000448)2.57753785
28Embryonal renal neoplasm (HP:0011794)2.52792781
29Lymphopenia (HP:0001888)2.52765745
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.51025661
31Basal cell carcinoma (HP:0002671)2.46986205
32Abnormality of cells of the lymphoid lineage (HP:0012140)2.46393952
33Birth length less than 3rd percentile (HP:0003561)2.42954617
34Abnormality of B cell number (HP:0010975)2.42767860
35Agammaglobulinemia (HP:0004432)2.39519550
36Viral hepatitis (HP:0006562)2.36460947
37Abnormality of DNA repair (HP:0003254)2.35685480
38Lymphoma (HP:0002665)2.29798885
39Subacute progressive viral hepatitis (HP:0006572)2.23969372
40Cafe-au-lait spot (HP:0000957)2.23903803
41Chronic diarrhea (HP:0002028)2.22377468
42Small intestinal stenosis (HP:0012848)2.18820167
43Duodenal stenosis (HP:0100867)2.18820167
44Myelodysplasia (HP:0002863)2.18774658
45Prostate neoplasm (HP:0100787)2.17568484
46Reticulocytopenia (HP:0001896)2.16937114
47Abnormality of pyrimidine metabolism (HP:0004353)2.15712670
48Erythema (HP:0010783)2.15340647
49Duplicated collecting system (HP:0000081)2.14471758
50Hepatitis (HP:0012115)2.12890571
51Panhypogammaglobulinemia (HP:0003139)2.10988547
52Hyperacusis (HP:0010780)2.10536326
53Microvesicular hepatic steatosis (HP:0001414)2.09810743
54Interstitial pulmonary disease (HP:0006530)2.08379337
55Leukopenia (HP:0001882)2.06789581
5611 pairs of ribs (HP:0000878)2.06616463
57Meningitis (HP:0001287)2.05147393
58Orthostatic hypotension (HP:0001278)2.05020762
59Ureteral duplication (HP:0000073)2.04647499
60Sandal gap (HP:0001852)2.03339447
61Hypergonadotropic hypogonadism (HP:0000815)2.02064357
62Autoimmune hemolytic anemia (HP:0001890)1.99185399
63Osteomyelitis (HP:0002754)1.97801150
64Deep philtrum (HP:0002002)1.97631859
65Dry hair (HP:0011359)1.97172470
66Hypoplasia of the thymus (HP:0000778)1.96626593
67Arteriovenous malformation (HP:0100026)1.96373675
68Abnormality of the columella (HP:0009929)1.92959414
69Abnormality of T cell physiology (HP:0011840)1.89489539
70Emphysema (HP:0002097)1.88671595
71High anterior hairline (HP:0009890)1.88198860
72Ectopic kidney (HP:0000086)1.87456034
73Micronodular cirrhosis (HP:0001413)1.86615905
74Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86232138
75Syringomyelia (HP:0003396)1.86117866
76Spinal cord lesions (HP:0100561)1.86117866
77Deep palmar crease (HP:0006191)1.85555673
78Short thumb (HP:0009778)1.82991003
79Lower limb hyperreflexia (HP:0002395)1.81443634
80High pitched voice (HP:0001620)1.80912820
81Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80235822
82Absent radius (HP:0003974)1.80179850
83Recurrent bacterial skin infections (HP:0005406)1.79885251
84Sloping forehead (HP:0000340)1.79533843
85Abnormality of chromosome segregation (HP:0002916)1.78983164
86Asymmetry of the thorax (HP:0001555)1.77829702
87Embryonal neoplasm (HP:0002898)1.77761378
88Mediastinal lymphadenopathy (HP:0100721)1.77658817
89Bone marrow hypocellularity (HP:0005528)1.77449280
90Abnormality of the duodenum (HP:0002246)1.77224479
91Large eyes (HP:0001090)1.75949686
92Abnormality of the renal collecting system (HP:0004742)1.75845698
93Renovascular hypertension (HP:0100817)1.74106330
94Combined immunodeficiency (HP:0005387)1.73285505
95Carpal bone hypoplasia (HP:0001498)1.73248545
96Abnormality of the distal phalanx of the thumb (HP:0009617)1.71924896
97Anal stenosis (HP:0002025)1.70781795
98Absent thumb (HP:0009777)1.70456953
99Progressive muscle weakness (HP:0003323)1.69530327
100IgG deficiency (HP:0004315)1.69081156

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK9.19103072
2TLK18.90672755
3VRK15.35971320
4RPS6KA53.29305299
5DAPK32.53794212
6STK41.96504776
7AURKA1.89807301
8SMG11.87723833
9CDC71.80663840
10EEF2K1.66140882
11BUB11.51323494
12CHEK21.41331677
13CDK121.40210915
14AURKB1.31064335
15PIM11.30082414
16SCYL21.25076356
17TRIB31.24463162
18TAF11.12644559
19MAP3K101.08629258
20PKN11.08394233
21ICK1.02754171
22RPS6KB20.91680556
23NME20.85209027
24PBK0.82959963
25MAP3K80.81489373
26SRPK10.79388252
27TTK0.78606787
28BTK0.77749913
29BRSK20.76374378
30ATR0.75717995
31BLK0.75326173
32CAMK1D0.70840735
33MELK0.64493629
34IRAK40.63419476
35NLK0.63065162
36MAPK110.62225341
37BRAF0.62178776
38PRKAA10.59662015
39CDK80.58595296
40NEK20.58539452
41AKT20.58014846
42CDK70.57965505
43EIF2AK30.52961902
44CSNK1A1L0.52256881
45PKN20.51877825
46MARK30.51190955
47BRD40.50269815
48CCNB10.49037032
49NEK10.49019149
50CHEK10.48635040
51CDK60.47865889
52PLK10.46123126
53MAP2K70.44671693
54ATM0.42760069
55CAMK1G0.42735545
56CSNK1G30.42478333
57WEE10.42018884
58SYK0.41189117
59CDK40.40664784
60MAP2K30.38420121
61JAK20.36384505
62PRKCQ0.36305359
63CSNK1G10.35474685
64PLK40.34322182
65CAMK40.32563395
66IRAK20.32493341
67MTOR0.31269287
68PRPF4B0.30845237
69MAP3K130.30693043
70TSSK60.29354521
71CDK20.29149008
72RAF10.28482749
73TRPM70.27838660
74NEK90.27016423
75CDK90.25256044
76RPS6KB10.24938752
77STK160.24906392
78PIK3CG0.24870516
79MAP3K20.24045399
80AKT30.23124423
81CDK10.23103474
82MST1R0.21272022
83PAK10.20951057
84MAPKAPK50.18534163
85TTN0.17880700
86IRAK30.16116834
87RPS6KA10.15725015
88RET0.14266665
89LYN0.13810178
90MAP2K20.13342075
91MAP4K10.13022923
92PLK30.12588609
93MAP3K140.12068215
94RPS6KA40.11246557
95FGFR30.11132028
96RPS6KL10.11100723
97RPS6KC10.11100723
98KSR20.11026148
99STK100.10469249
100BRSK10.10111220

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050348.05340326
2* Viral carcinogenesis_Homo sapiens_hsa052033.67468789
3DNA replication_Homo sapiens_hsa030302.55503175
4Transcriptional misregulation in cancer_Homo sapiens_hsa052022.09883143
5* Systemic lupus erythematosus_Homo sapiens_hsa0532211.4615041
6Mismatch repair_Homo sapiens_hsa034301.46644484
7Cell cycle_Homo sapiens_hsa041101.36077744
8Fanconi anemia pathway_Homo sapiens_hsa034601.19149091
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19077360
10Non-homologous end-joining_Homo sapiens_hsa034501.15762222
11Primary immunodeficiency_Homo sapiens_hsa053401.10292355
12Homologous recombination_Homo sapiens_hsa034401.06125559
13B cell receptor signaling pathway_Homo sapiens_hsa046621.05431271
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02521201
15Nucleotide excision repair_Homo sapiens_hsa034200.99331335
16Intestinal immune network for IgA production_Homo sapiens_hsa046720.93354503
17Base excision repair_Homo sapiens_hsa034100.92602849
18Non-small cell lung cancer_Homo sapiens_hsa052230.88625929
19p53 signaling pathway_Homo sapiens_hsa041150.79091661
20Asthma_Homo sapiens_hsa053100.71699137
21Allograft rejection_Homo sapiens_hsa053300.70083600
22Autoimmune thyroid disease_Homo sapiens_hsa053200.66051399
23Chronic myeloid leukemia_Homo sapiens_hsa052200.64883730
24RNA transport_Homo sapiens_hsa030130.61846754
25Glioma_Homo sapiens_hsa052140.61395073
26Pancreatic cancer_Homo sapiens_hsa052120.61197359
27Thyroid cancer_Homo sapiens_hsa052160.60838960
28Herpes simplex infection_Homo sapiens_hsa051680.60371804
29HTLV-I infection_Homo sapiens_hsa051660.60182363
30Pyrimidine metabolism_Homo sapiens_hsa002400.58225778
31Graft-versus-host disease_Homo sapiens_hsa053320.54907714
32Leishmaniasis_Homo sapiens_hsa051400.53998433
33Spliceosome_Homo sapiens_hsa030400.53387466
34MicroRNAs in cancer_Homo sapiens_hsa052060.53049110
35Epstein-Barr virus infection_Homo sapiens_hsa051690.51282734
36Sulfur relay system_Homo sapiens_hsa041220.49087436
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48925721
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48894305
39Hepatitis B_Homo sapiens_hsa051610.48717788
40Pentose phosphate pathway_Homo sapiens_hsa000300.47360789
41Acute myeloid leukemia_Homo sapiens_hsa052210.47299595
42Small cell lung cancer_Homo sapiens_hsa052220.45878159
43Bladder cancer_Homo sapiens_hsa052190.45515094
44Prostate cancer_Homo sapiens_hsa052150.45183442
45Central carbon metabolism in cancer_Homo sapiens_hsa052300.44549412
46Colorectal cancer_Homo sapiens_hsa052100.44374064
47Viral myocarditis_Homo sapiens_hsa054160.44069628
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43583891
49Apoptosis_Homo sapiens_hsa042100.43539682
50Type I diabetes mellitus_Homo sapiens_hsa049400.43284954
51Endometrial cancer_Homo sapiens_hsa052130.42757848
52Influenza A_Homo sapiens_hsa051640.42546814
53One carbon pool by folate_Homo sapiens_hsa006700.42477600
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42438412
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38856223
56mRNA surveillance pathway_Homo sapiens_hsa030150.38751558
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.37969072
58Inositol phosphate metabolism_Homo sapiens_hsa005620.36882312
59Measles_Homo sapiens_hsa051620.36555669
60Antigen processing and presentation_Homo sapiens_hsa046120.33684864
61Lysine degradation_Homo sapiens_hsa003100.33523468
62Biosynthesis of amino acids_Homo sapiens_hsa012300.32395161
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31351640
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30936148
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29785973
66FoxO signaling pathway_Homo sapiens_hsa040680.29365194
67mTOR signaling pathway_Homo sapiens_hsa041500.29196618
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28918981
69Purine metabolism_Homo sapiens_hsa002300.28059643
70Fructose and mannose metabolism_Homo sapiens_hsa000510.26192128
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.25972756
72Melanoma_Homo sapiens_hsa052180.25657278
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24847603
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23932589
75Oocyte meiosis_Homo sapiens_hsa041140.23324524
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23060306
77HIF-1 signaling pathway_Homo sapiens_hsa040660.21564667
78Hematopoietic cell lineage_Homo sapiens_hsa046400.21446566
79Toxoplasmosis_Homo sapiens_hsa051450.20423120
80Selenocompound metabolism_Homo sapiens_hsa004500.20334802
81ErbB signaling pathway_Homo sapiens_hsa040120.19518358
82Staphylococcus aureus infection_Homo sapiens_hsa051500.18039190
83RNA degradation_Homo sapiens_hsa030180.18000380
84RNA polymerase_Homo sapiens_hsa030200.17440456
85Vitamin B6 metabolism_Homo sapiens_hsa007500.17139800
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.16349265
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.15982873
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15436129
89N-Glycan biosynthesis_Homo sapiens_hsa005100.15008954
90T cell receptor signaling pathway_Homo sapiens_hsa046600.14688827
91Ribosome_Homo sapiens_hsa030100.13909505
92Osteoclast differentiation_Homo sapiens_hsa043800.13694532
93Basal cell carcinoma_Homo sapiens_hsa052170.13353700
94Prolactin signaling pathway_Homo sapiens_hsa049170.12672728
95Galactose metabolism_Homo sapiens_hsa000520.12415444
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.11962862
97Tuberculosis_Homo sapiens_hsa051520.11508889
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11203769
99Type II diabetes mellitus_Homo sapiens_hsa049300.09966881
100TGF-beta signaling pathway_Homo sapiens_hsa043500.09165452

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