HIST2H3C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome organization (GO:0034723)9.20457794
2DNA replication-dependent nucleosome assembly (GO:0006335)9.20457794
3mucosal immune response (GO:0002385)9.17652440
4antibacterial humoral response (GO:0019731)8.84129732
5organ or tissue specific immune response (GO:0002251)8.34039096
6antimicrobial humoral response (GO:0019730)8.11075412
7chromatin assembly (GO:0031497)7.61714516
8nucleosome assembly (GO:0006334)7.42101879
9protein-DNA complex assembly (GO:0065004)6.33575302
10nucleosome organization (GO:0034728)6.24979220
11protein-DNA complex subunit organization (GO:0071824)5.49559262
12chromatin assembly or disassembly (GO:0006333)5.44694313
13nuclear pore complex assembly (GO:0051292)5.41335115
14DNA strand elongation involved in DNA replication (GO:0006271)5.37676849
15DNA unwinding involved in DNA replication (GO:0006268)5.33631110
16DNA strand elongation (GO:0022616)5.19952916
17DNA replication initiation (GO:0006270)5.04666724
18nuclear pore organization (GO:0006999)5.02159947
19telomere maintenance via semi-conservative replication (GO:0032201)4.70488693
20protein localization to chromosome, centromeric region (GO:0071459)4.51749254
21regulation of histone H3-K9 methylation (GO:0051570)4.42103041
22mitotic sister chromatid segregation (GO:0000070)4.32507473
23viral mRNA export from host cell nucleus (GO:0046784)4.30330027
24mitotic chromosome condensation (GO:0007076)4.29931261
25pore complex assembly (GO:0046931)4.17889270
26sister chromatid segregation (GO:0000819)4.01420035
27telomere maintenance via recombination (GO:0000722)3.98551258
28negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.92614666
29regulation of translational fidelity (GO:0006450)3.81914581
30proline biosynthetic process (GO:0006561)3.75148815
31mitotic recombination (GO:0006312)3.69484290
32defense response to Gram-positive bacterium (GO:0050830)3.68063120
33DNA replication checkpoint (GO:0000076)3.66589037
34mitotic nuclear envelope disassembly (GO:0007077)3.62018122
35DNA duplex unwinding (GO:0032508)3.61143481
36regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.56932776
37CENP-A containing nucleosome assembly (GO:0034080)3.54661204
38chromatin remodeling at centromere (GO:0031055)3.47606500
39DNA geometric change (GO:0032392)3.46014176
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.39450587
41peptidyl-arginine omega-N-methylation (GO:0035247)3.37915022
42negative regulation of B cell apoptotic process (GO:0002903)3.34138329
43nuclear envelope disassembly (GO:0051081)3.32958438
44membrane disassembly (GO:0030397)3.32958438
45protein localization to kinetochore (GO:0034501)3.24453417
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.24433550
47DNA synthesis involved in DNA repair (GO:0000731)3.21982799
48regulation of sister chromatid cohesion (GO:0007063)3.17002236
49regulation of mammary gland epithelial cell proliferation (GO:0033599)3.09834989
50mitochondrial DNA metabolic process (GO:0032042)3.08884919
51telomere organization (GO:0032200)3.05138788
52telomere maintenance (GO:0000723)3.03187928
53meiotic chromosome segregation (GO:0045132)3.00948247
54telomere maintenance via telomere lengthening (GO:0010833)3.00508119
55positive regulation of chromosome segregation (GO:0051984)2.98796483
56regulation of megakaryocyte differentiation (GO:0045652)2.96657372
57positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.94415859
58DNA conformation change (GO:0071103)2.91731890
59regulation of centrosome cycle (GO:0046605)2.91015059
60rRNA transcription (GO:0009303)2.90575826
61translesion synthesis (GO:0019985)2.90050130
62folic acid metabolic process (GO:0046655)2.86766718
63maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.86551596
64regulation of chromosome segregation (GO:0051983)2.80355417
65positive regulation of mitotic sister chromatid separation (GO:1901970)2.76979664
66positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.76979664
67positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.76979664
68protein complex localization (GO:0031503)2.76910753
69nuclear envelope organization (GO:0006998)2.76253141
70histone phosphorylation (GO:0016572)2.73033832
71non-recombinational repair (GO:0000726)2.72343177
72double-strand break repair via nonhomologous end joining (GO:0006303)2.72343177
73somatic hypermutation of immunoglobulin genes (GO:0016446)2.70423484
74somatic diversification of immune receptors via somatic mutation (GO:0002566)2.70423484
75spliceosomal tri-snRNP complex assembly (GO:0000244)2.69357927
76DNA replication-independent nucleosome assembly (GO:0006336)2.68489307
77DNA replication-independent nucleosome organization (GO:0034724)2.68489307
78chromosome condensation (GO:0030261)2.67960348
79cellular protein complex localization (GO:0034629)2.67916862
80negative regulation of chromosome segregation (GO:0051985)2.67358192
81histone arginine methylation (GO:0034969)2.67143368
82V(D)J recombination (GO:0033151)2.66809979
83peptidyl-arginine methylation (GO:0018216)2.66641838
84peptidyl-arginine N-methylation (GO:0035246)2.66641838
85cellular response to UV (GO:0034644)2.66114694
86ribosomal small subunit biogenesis (GO:0042274)2.65452495
87nucleobase-containing small molecule interconversion (GO:0015949)2.64990152
88positive regulation of cell cycle checkpoint (GO:1901978)2.64924743
89mitotic metaphase plate congression (GO:0007080)2.64305427
90B cell receptor signaling pathway (GO:0050853)2.63336450
91T cell lineage commitment (GO:0002360)2.62447588
92GDP-mannose metabolic process (GO:0019673)2.61750341
93ATP-dependent chromatin remodeling (GO:0043044)2.60357158
94B cell proliferation (GO:0042100)2.59528442
95snRNA metabolic process (GO:0016073)2.58425211
96protein-DNA complex disassembly (GO:0032986)2.54597401
97nucleosome disassembly (GO:0006337)2.54597401
98peptidyl-lysine dimethylation (GO:0018027)2.52798370
99replicative senescence (GO:0090399)2.51135119
100innate immune response in mucosa (GO:0002227)11.1344102

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.18035228
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.93729794
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.72960336
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.34990057
5TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.01343148
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.87259991
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.65342992
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.49470913
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.46133570
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.15874845
11MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13953013
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.02554471
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse15.0807615
14HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.95292346
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.93378821
16* SOX2_16153702_ChIP-ChIP_HESCs_Human1.91461603
17CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.91100644
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89268882
19VDR_21846776_ChIP-Seq_THP-1_Human1.88911787
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82479347
21NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82442802
22MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78719052
23MYC_22102868_ChIP-Seq_BL_Human1.72877721
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.68239529
25ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65566147
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63568795
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52651897
28ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52065722
29DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50477851
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49104187
31XRN2_22483619_ChIP-Seq_HELA_Human1.43991808
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39310153
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32720420
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31249104
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31198847
36KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30106524
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28701611
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26911221
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26240943
40CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26149239
41VDR_23849224_ChIP-Seq_CD4+_Human1.26032533
42CIITA_25753668_ChIP-Seq_RAJI_Human1.17993461
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17565089
44DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17127426
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16051580
46SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.15308886
47MAF_26560356_Chip-Seq_TH1_Human1.15185872
48AR_21909140_ChIP-Seq_LNCAP_Human1.14772462
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13819974
50DCP1A_22483619_ChIP-Seq_HELA_Human1.12394374
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.10595444
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.06677025
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.03719304
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00732890
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00387423
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00015530
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98746610
58ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97202041
59PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97179655
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97021219
61SOX2_18692474_ChIP-Seq_MESCs_Mouse0.96378076
62FOXP3_21729870_ChIP-Seq_TREG_Human0.95507902
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94360008
64BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93221293
65TP63_17297297_ChIP-ChIP_HaCaT_Human0.91860490
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91621608
67NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91377485
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91154032
69ZNF263_19887448_ChIP-Seq_K562_Human0.90032874
70ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89535066
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88825476
72GATA1_22025678_ChIP-Seq_K562_Human0.88623630
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.88592112
74ETS1_22383799_ChIP-Seq_G1ME_Mouse0.87736562
75* NANOG_16153702_ChIP-ChIP_HESCs_Human0.87464638
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.87403009
77PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87322885
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86511570
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85753219
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84320321
81TTF2_22483619_ChIP-Seq_HELA_Human0.82890758
82EGR1_19374776_ChIP-ChIP_THP-1_Human0.82605754
83* MYC_18940864_ChIP-ChIP_HL60_Human0.82245931
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.80542335
85GABP_19822575_ChIP-Seq_HepG2_Human0.80503919
86ELF1_17652178_ChIP-ChIP_JURKAT_Human0.80302839
87KDM5A_27292631_Chip-Seq_BREAST_Human0.79624471
88* IRF1_19129219_ChIP-ChIP_H3396_Human0.78090221
89ELK1_19687146_ChIP-ChIP_HELA_Human0.77009580
90MYCN_18555785_ChIP-Seq_MESCs_Mouse0.76537532
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.75210642
92CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75117587
93EST1_17652178_ChIP-ChIP_JURKAT_Human0.74679811
94MAF_26560356_Chip-Seq_TH2_Human0.74428589
95YY1_21170310_ChIP-Seq_MESCs_Mouse0.72894150
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.72713498
97UTX_26944678_Chip-Seq_JUKART_Human0.72394767
98PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71376255
99* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.70590484
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.70244231

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.29202650
2MP0003111_abnormal_nucleus_morphology4.72625413
3MP0003077_abnormal_cell_cycle4.14599345
4MP0003693_abnormal_embryo_hatching4.10692908
5MP0008057_abnormal_DNA_replication3.87806020
6MP0004957_abnormal_blastocyst_morpholog3.25760602
7MP0005645_abnormal_hypothalamus_physiol2.87197027
8MP0000685_abnormal_immune_system2.62444739
9MP0003763_abnormal_thymus_physiology2.34000318
10MP0008058_abnormal_DNA_repair2.31837410
11MP0010352_gastrointestinal_tract_polyps2.27956362
12MP0008007_abnormal_cellular_replicative2.27465838
13MP0002009_preneoplasia2.22256760
14MP0010307_abnormal_tumor_latency2.21068824
15MP0001661_extended_life_span2.20796535
16MP0008932_abnormal_embryonic_tissue2.19715013
17MP0000350_abnormal_cell_proliferation2.10638808
18MP0005623_abnormal_meninges_morphology2.05026066
19MP0003786_premature_aging2.03491823
20MP0010234_abnormal_vibrissa_follicle1.96164384
21MP0002396_abnormal_hematopoietic_system1.86246709
22MP0005076_abnormal_cell_differentiation1.83344250
23MP0002877_abnormal_melanocyte_morpholog1.75121900
24MP0002166_altered_tumor_susceptibility1.74966543
25MP0004185_abnormal_adipocyte_glucose1.74663423
26MP0000490_abnormal_crypts_of1.71877643
27MP0000537_abnormal_urethra_morphology1.71825526
28MP0002163_abnormal_gland_morphology1.63621544
29MP0002019_abnormal_tumor_incidence1.60061787
30MP0005671_abnormal_response_to1.55302440
31MP0004808_abnormal_hematopoietic_stem1.53968762
32MP0000313_abnormal_cell_death1.50622642
33MP0005083_abnormal_biliary_tract1.49662535
34MP0001835_abnormal_antigen_presentation1.46988877
35MP0002398_abnormal_bone_marrow1.45483210
36MP0001800_abnormal_humoral_immune1.44604133
37MP0000703_abnormal_thymus_morphology1.34781181
38MP0001346_abnormal_lacrimal_gland1.34388850
39MP0002006_tumorigenesis1.33841571
40MP0001730_embryonic_growth_arrest1.30780268
41MP0005220_abnormal_exocrine_pancreas1.28866362
42MP0002722_abnormal_immune_system1.28536403
43MP0002080_prenatal_lethality1.26106557
44MP0000358_abnormal_cell_content/1.25842848
45MP0001727_abnormal_embryo_implantation1.22384407
46MP0001672_abnormal_embryogenesis/_devel1.19649517
47MP0005380_embryogenesis_phenotype1.19649517
48MP0006035_abnormal_mitochondrial_morpho1.18733406
49MP0005451_abnormal_body_composition1.17515557
50MP0000015_abnormal_ear_pigmentation1.13567550
51MP0002086_abnormal_extraembryonic_tissu1.13237583
52MP0000689_abnormal_spleen_morphology1.12009279
53MP0000013_abnormal_adipose_tissue1.09451086
54MP0001849_ear_inflammation1.09449239
55MP0000003_abnormal_adipose_tissue1.09243892
56MP0003984_embryonic_growth_retardation1.09003665
57MP0001697_abnormal_embryo_size1.08807250
58MP0009697_abnormal_copulation1.07539962
59MP0002429_abnormal_blood_cell1.06016550
60MP0002160_abnormal_reproductive_system1.05991596
61MP0001348_abnormal_lacrimal_gland1.03467541
62MP0002088_abnormal_embryonic_growth/wei1.03340155
63MP0001790_abnormal_immune_system1.01794206
64MP0005387_immune_system_phenotype1.01794206
65MP0000716_abnormal_immune_system0.96290836
66MP0005171_absent_coat_pigmentation0.93219491
67MP0005000_abnormal_immune_tolerance0.92420920
68MP0004233_abnormal_muscle_weight0.92338436
69MP0002085_abnormal_embryonic_tissue0.89215613
70MP0005384_cellular_phenotype0.87638377
71MP0005621_abnormal_cell_physiology0.86906467
72MP0002452_abnormal_antigen_presenting0.85617302
73MP0003705_abnormal_hypodermis_morpholog0.85206940
74MP0002420_abnormal_adaptive_immunity0.83586592
75MP0009333_abnormal_splenocyte_physiolog0.83334701
76MP0002084_abnormal_developmental_patter0.82605561
77MP0005501_abnormal_skin_physiology0.81175400
78MP0000747_muscle_weakness0.79900614
79MP0001819_abnormal_immune_cell0.79422082
80MP0002723_abnormal_immune_serum0.79389714
81MP0003315_abnormal_perineum_morphology0.78442795
82MP0003718_maternal_effect0.74900817
83MP0002092_abnormal_eye_morphology0.74418044
84MP0000733_abnormal_muscle_development0.74249600
85MP0005310_abnormal_salivary_gland0.74190768
86MP0002111_abnormal_tail_morphology0.73581788
87MP0001873_stomach_inflammation0.71975621
88MP0003453_abnormal_keratinocyte_physiol0.71737161
89MP0002210_abnormal_sex_determination0.71298728
90MP0002697_abnormal_eye_size0.70323402
91MP0002928_abnormal_bile_duct0.68369223
92MP0004197_abnormal_fetal_growth/weight/0.65653717
93MP0003937_abnormal_limbs/digits/tail_de0.65474252
94MP0001919_abnormal_reproductive_system0.62308131
95MP0003183_abnormal_peptide_metabolism0.62052096
96MP0003699_abnormal_female_reproductive0.60658738
97MP0009046_muscle_twitch0.60604635
98MP0009278_abnormal_bone_marrow0.60007021
99MP0000477_abnormal_intestine_morphology0.59514640
100MP0003385_abnormal_body_wall0.59490569

Predicted human phenotypes

RankGene SetZ-score
1IgA deficiency (HP:0002720)5.60925647
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.46905458
3IgM deficiency (HP:0002850)5.29521283
4Gastrointestinal stroma tumor (HP:0100723)4.78986235
5Chromsome breakage (HP:0040012)4.76449191
6Squamous cell carcinoma (HP:0002860)4.56379857
7Colitis (HP:0002583)3.83205290
8Recurrent sinusitis (HP:0011108)3.42636116
9Cellulitis (HP:0100658)3.32521201
10Microvesicular hepatic steatosis (HP:0001414)3.30535757
11Agammaglobulinemia (HP:0004432)3.19558560
12Birth length less than 3rd percentile (HP:0003561)3.09836238
13Recurrent bronchitis (HP:0002837)3.00282438
14Abnormality of the preputium (HP:0100587)2.99784193
15Basal cell carcinoma (HP:0002671)2.92976608
16Aplasia/Hypoplasia of the uvula (HP:0010293)2.91009800
17Reticulocytopenia (HP:0001896)2.89964627
18Dry hair (HP:0011359)2.89630919
19Abnormality of chromosome stability (HP:0003220)2.87001334
20Lymphopenia (HP:0001888)2.83728743
21Abnormality of cells of the lymphoid lineage (HP:0012140)2.83284894
22Aplasia/Hypoplasia of the sacrum (HP:0008517)2.83007333
23Abnormality of DNA repair (HP:0003254)2.69228283
24Emphysema (HP:0002097)2.67883968
25Abnormality of the ileum (HP:0001549)2.67074432
26Poikiloderma (HP:0001029)2.63311207
27Progressive muscle weakness (HP:0003323)2.56469651
28Meckel diverticulum (HP:0002245)2.54447780
29Breast hypoplasia (HP:0003187)2.49178978
30Abnormality of the carotid arteries (HP:0005344)2.47372222
31Entropion (HP:0000621)2.44771986
32B lymphocytopenia (HP:0010976)2.40709276
33Leukopenia (HP:0001882)2.40664554
34Onycholysis (HP:0001806)2.36317339
35Lymphoma (HP:0002665)2.36301635
36Short thumb (HP:0009778)2.32558353
37Abnormality of pyrimidine metabolism (HP:0004353)2.28942120
38Hyperacusis (HP:0010780)2.28107658
39Ureteral duplication (HP:0000073)2.26397568
40Ragged-red muscle fibers (HP:0003200)2.24395969
41Broad distal phalanx of finger (HP:0009836)2.21273610
42Progressive external ophthalmoplegia (HP:0000590)2.20826176
43Clubbing of toes (HP:0100760)2.18930099
44Meningitis (HP:0001287)2.14119013
45Duplicated collecting system (HP:0000081)2.09206606
46Medulloblastoma (HP:0002885)2.08529497
47Erythema (HP:0010783)2.08448088
48Inflammation of the large intestine (HP:0002037)2.04795422
49Hypergonadotropic hypogonadism (HP:0000815)2.03132145
5011 pairs of ribs (HP:0000878)2.02724892
51Absent thumb (HP:0009777)2.02029451
52Recurrent viral infections (HP:0004429)2.00458646
53Gastrointestinal inflammation (HP:0004386)1.99807844
54Abnormality of cells of the erythroid lineage (HP:0012130)1.99547913
55IgG deficiency (HP:0004315)1.99290616
56Ridged nail (HP:0001807)1.98691008
57Hepatitis (HP:0012115)1.98344768
58Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.98163540
59Lipid accumulation in hepatocytes (HP:0006561)1.98134184
60Recurrent pneumonia (HP:0006532)1.97180017
61Hypoplasia of the pons (HP:0012110)1.95969117
62Small intestinal stenosis (HP:0012848)1.95258217
63Duodenal stenosis (HP:0100867)1.95258217
64Ulnar bowing (HP:0003031)1.95021904
65Abnormal number of erythroid precursors (HP:0012131)1.93277649
66Cafe-au-lait spot (HP:0000957)1.91746081
67Abnormality of T cell physiology (HP:0011840)1.90129747
68Abnormality of B cell number (HP:0010975)1.88904916
69Chronic diarrhea (HP:0002028)1.88837857
70Cholecystitis (HP:0001082)1.87477406
71Abnormal gallbladder physiology (HP:0012438)1.87477406
72Vaginal fistula (HP:0004320)1.87256653
73Recurrent lower respiratory tract infections (HP:0002783)1.87226372
74Orthostatic hypotension (HP:0001278)1.85293356
75Acute lymphatic leukemia (HP:0006721)1.82312469
76Prostate neoplasm (HP:0100787)1.82280686
77Rectal fistula (HP:0100590)1.82170665
78Rectovaginal fistula (HP:0000143)1.82170665
79Increased muscle lipid content (HP:0009058)1.81581632
80Septate vagina (HP:0001153)1.81213575
81Insomnia (HP:0100785)1.80255739
82Cutaneous melanoma (HP:0012056)1.80239979
83Abnormality of cochlea (HP:0000375)1.79577821
84Intestinal fistula (HP:0100819)1.79387986
85Absent radius (HP:0003974)1.79053011
86Myelodysplasia (HP:0002863)1.78757686
87Viral hepatitis (HP:0006562)1.76905015
88Increased intramyocellular lipid droplets (HP:0012240)1.76176751
89Osteomyelitis (HP:0002754)1.75828568
90Bone marrow hypocellularity (HP:0005528)1.74597545
91Astrocytoma (HP:0009592)1.73493402
92Abnormality of the astrocytes (HP:0100707)1.73493402
93Abnormality of the renal collecting system (HP:0004742)1.73217914
94Abnormality of the pons (HP:0007361)1.71658564
95Asymmetry of the thorax (HP:0001555)1.71383674
96Abnormality of the fingertips (HP:0001211)1.69520974
97Micronodular cirrhosis (HP:0001413)1.68884889
98Prominent nose (HP:0000448)1.66647507
99Nephroblastoma (Wilms tumor) (HP:0002667)1.65683494
100External ear malformation (HP:0008572)1.62902249

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK9.08484611
2TLK18.85237462
3VRK15.44074158
4RPS6KA53.32054874
5DAPK32.81148780
6BUB12.42558102
7SMG12.28656803
8CDC71.90892836
9STK41.75279136
10TRIB31.65084660
11EEF2K1.64017179
12* AURKA1.63763951
13CHEK21.47590482
14AURKB1.32352440
15NME21.31069418
16PIM11.20407745
17PKN11.17942705
18PBK1.17874444
19ICK1.15701115
20MAP3K101.04306578
21NEK11.04192596
22TAF11.02589120
23SCYL21.00807156
24SRPK10.93208474
25TTK0.83324891
26RPS6KB20.82681893
27IRAK40.80860725
28PIM20.80668125
29ATR0.80223527
30MAP3K80.78238582
31CCNB10.77893018
32BLK0.76644715
33BRAF0.75162227
34BCKDK0.74030166
35CDK120.72937894
36MAPK110.72080603
37AKT20.67703747
38IRAK30.64716398
39CDK80.64108108
40STK160.61988034
41CDK70.61150105
42PLK10.58165753
43WEE10.56743639
44BRSK20.55364329
45ARAF0.55235675
46CDK40.51284017
47NEK90.51081284
48PKN20.47097037
49CHEK10.46156506
50PRKAA10.45294583
51MELK0.44814185
52BTK0.44182179
53KDR0.41490568
54MAP2K30.41440195
55CSNK1G30.39530594
56NEK20.39392879
57PDK20.39343143
58CSNK1A1L0.37335813
59EIF2AK30.36594142
60MAP2K70.35033471
61VRK20.33968064
62CDK60.33605995
63RAF10.33162649
64PRPF4B0.33151980
65TESK20.31792026
66PAK10.31670249
67MAP4K10.31041552
68PRKCQ0.29715494
69BRSK10.29290868
70CDK20.28990911
71MAPKAPK50.28588121
72TSSK60.28177996
73SYK0.27780419
74CSNK1G10.27096658
75ATM0.26789874
76TTN0.26539474
77PLK40.24759647
78MST1R0.23677710
79CDK90.23372688
80TBK10.22536376
81CDK10.20789054
82IKBKB0.19081168
83MTOR0.17726989
84LYN0.14934918
85CAMK40.14667940
86MAP2K20.12870053
87MAP3K90.12782327
88JAK20.12724599
89MAP3K140.12554765
90CAMK1D0.10708631
91SIK10.10488803
92RPS6KB10.09544959
93RPS6KA10.09327507
94PRKCI0.09082667
95PRKCD0.08934181
96RPS6KL10.08392514
97RPS6KC10.08392514
98CSNK1G20.07972485
99MAPK120.07962212
100CDK150.07320857

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050347.74797515
2Viral carcinogenesis_Homo sapiens_hsa052033.41603197
3DNA replication_Homo sapiens_hsa030302.88581459
4* Systemic lupus erythematosus_Homo sapiens_hsa0532211.0689149
5Mismatch repair_Homo sapiens_hsa034301.80505433
6* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.66447582
7Sulfur relay system_Homo sapiens_hsa041221.54526522
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41668105
9Base excision repair_Homo sapiens_hsa034101.39750004
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39514345
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.37317045
12Cell cycle_Homo sapiens_hsa041101.35626206
13Primary immunodeficiency_Homo sapiens_hsa053401.35612363
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.29158965
15Fanconi anemia pathway_Homo sapiens_hsa034601.21659519
16Homologous recombination_Homo sapiens_hsa034401.19079402
17Non-homologous end-joining_Homo sapiens_hsa034501.16061140
18Nucleotide excision repair_Homo sapiens_hsa034201.15076447
19Allograft rejection_Homo sapiens_hsa053301.03590910
20Asthma_Homo sapiens_hsa053101.02320716
21Biosynthesis of amino acids_Homo sapiens_hsa012300.99754781
22Autoimmune thyroid disease_Homo sapiens_hsa053200.96532379
23Pentose phosphate pathway_Homo sapiens_hsa000300.88045266
24Pyrimidine metabolism_Homo sapiens_hsa002400.87670283
25B cell receptor signaling pathway_Homo sapiens_hsa046620.81736413
26Fructose and mannose metabolism_Homo sapiens_hsa000510.81661534
27Vitamin B6 metabolism_Homo sapiens_hsa007500.79962999
28p53 signaling pathway_Homo sapiens_hsa041150.78165977
29Graft-versus-host disease_Homo sapiens_hsa053320.76304915
30Ribosome_Homo sapiens_hsa030100.73957640
31Viral myocarditis_Homo sapiens_hsa054160.72696947
32Spliceosome_Homo sapiens_hsa030400.72185878
33RNA transport_Homo sapiens_hsa030130.71508629
34One carbon pool by folate_Homo sapiens_hsa006700.68009712
35Type I diabetes mellitus_Homo sapiens_hsa049400.64314257
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62929955
37Epstein-Barr virus infection_Homo sapiens_hsa051690.60447848
38HTLV-I infection_Homo sapiens_hsa051660.57482663
39Carbon metabolism_Homo sapiens_hsa012000.56489046
40Herpes simplex infection_Homo sapiens_hsa051680.54808104
41Central carbon metabolism in cancer_Homo sapiens_hsa052300.54589167
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52254561
43Bladder cancer_Homo sapiens_hsa052190.47365991
44Non-small cell lung cancer_Homo sapiens_hsa052230.45585016
45RNA polymerase_Homo sapiens_hsa030200.45149830
46Antigen processing and presentation_Homo sapiens_hsa046120.44459289
47Galactose metabolism_Homo sapiens_hsa000520.42349186
48Selenocompound metabolism_Homo sapiens_hsa004500.39964045
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39088851
50Purine metabolism_Homo sapiens_hsa002300.38295866
51Leishmaniasis_Homo sapiens_hsa051400.38158724
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37099328
53N-Glycan biosynthesis_Homo sapiens_hsa005100.36102574
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34990301
55Apoptosis_Homo sapiens_hsa042100.34235982
56Chronic myeloid leukemia_Homo sapiens_hsa052200.33264787
57Pancreatic cancer_Homo sapiens_hsa052120.32582037
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.32113232
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31697850
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30992690
61Influenza A_Homo sapiens_hsa051640.30772576
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30417510
63Basal cell carcinoma_Homo sapiens_hsa052170.28715785
64mRNA surveillance pathway_Homo sapiens_hsa030150.28135883
65Hepatitis B_Homo sapiens_hsa051610.27773603
66Small cell lung cancer_Homo sapiens_hsa052220.27763446
67Thyroid cancer_Homo sapiens_hsa052160.26444767
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26113371
69Phenylalanine metabolism_Homo sapiens_hsa003600.26096886
70Pyruvate metabolism_Homo sapiens_hsa006200.25980418
71Colorectal cancer_Homo sapiens_hsa052100.25542148
72MicroRNAs in cancer_Homo sapiens_hsa052060.24195201
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23623546
74Proteasome_Homo sapiens_hsa030500.22918892
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22546356
76Glioma_Homo sapiens_hsa052140.22265255
77RNA degradation_Homo sapiens_hsa030180.20327721
78Lysine degradation_Homo sapiens_hsa003100.18776536
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17622900
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.17221548
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17028027
82Arginine biosynthesis_Homo sapiens_hsa002200.16586570
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15868965
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15708123
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.15205415
86Acute myeloid leukemia_Homo sapiens_hsa052210.14470643
87Measles_Homo sapiens_hsa051620.12734315
88Inositol phosphate metabolism_Homo sapiens_hsa005620.12689223
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.12594414
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.12526747
91Toxoplasmosis_Homo sapiens_hsa051450.12198038
92Oocyte meiosis_Homo sapiens_hsa041140.11724871
93Endometrial cancer_Homo sapiens_hsa052130.10084872
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.09605984
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.09470715
96Prostate cancer_Homo sapiens_hsa052150.07423162
97Hedgehog signaling pathway_Homo sapiens_hsa043400.07091585
98HIF-1 signaling pathway_Homo sapiens_hsa040660.05652618
99Hippo signaling pathway_Homo sapiens_hsa043900.04386353
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.04003011

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