HIST2H3D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome assembly (GO:0006335)9.58844393
2DNA replication-dependent nucleosome organization (GO:0034723)9.58844393
3mucosal immune response (GO:0002385)9.03431254
4antibacterial humoral response (GO:0019731)8.71178410
5organ or tissue specific immune response (GO:0002251)8.21549135
6antimicrobial humoral response (GO:0019730)7.99557174
7chromatin assembly (GO:0031497)7.77255374
8nucleosome assembly (GO:0006334)7.53203790
9protein-DNA complex assembly (GO:0065004)6.43588609
10nucleosome organization (GO:0034728)6.35445714
11protein-DNA complex subunit organization (GO:0071824)5.59203854
12chromatin assembly or disassembly (GO:0006333)5.42459462
13DNA strand elongation involved in DNA replication (GO:0006271)5.14150741
14DNA unwinding involved in DNA replication (GO:0006268)5.03056101
15nuclear pore complex assembly (GO:0051292)4.99619680
16DNA strand elongation (GO:0022616)4.96283541
17DNA replication initiation (GO:0006270)4.81963294
18regulation of histone H3-K9 methylation (GO:0051570)4.75876811
19nuclear pore organization (GO:0006999)4.63411862
20telomere maintenance via semi-conservative replication (GO:0032201)4.49425862
21negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.40190550
22viral mRNA export from host cell nucleus (GO:0046784)4.17327866
23protein localization to chromosome, centromeric region (GO:0071459)4.08460998
24mitotic sister chromatid segregation (GO:0000070)3.93670507
25pore complex assembly (GO:0046931)3.88209446
26mitotic chromosome condensation (GO:0007076)3.86082353
27telomere maintenance via recombination (GO:0000722)3.78318291
28proline biosynthetic process (GO:0006561)3.77304776
29regulation of translational fidelity (GO:0006450)3.67379136
30peptidyl-arginine omega-N-methylation (GO:0035247)3.64501391
31negative regulation of B cell apoptotic process (GO:0002903)3.62424343
32defense response to Gram-positive bacterium (GO:0050830)3.61261196
33sister chromatid segregation (GO:0000819)3.61033526
34positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.53404013
35CENP-A containing nucleosome assembly (GO:0034080)3.48378647
36chromatin remodeling at centromere (GO:0031055)3.47839960
37mitotic recombination (GO:0006312)3.46911461
38mitotic nuclear envelope disassembly (GO:0007077)3.38269226
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.27145849
40DNA duplex unwinding (GO:0032508)3.25566062
41regulation of megakaryocyte differentiation (GO:0045652)3.21190927
42DNA replication checkpoint (GO:0000076)3.18327222
43immunoglobulin mediated immune response (GO:0016064)3.16463374
44regulation of mammary gland epithelial cell proliferation (GO:0033599)3.15515561
45DNA geometric change (GO:0032392)3.11014299
46nuclear envelope disassembly (GO:0051081)3.10272681
47membrane disassembly (GO:0030397)3.10272681
48T-helper 1 type immune response (GO:0042088)3.06277217
49histone arginine methylation (GO:0034969)3.03936314
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.03458454
51B cell receptor signaling pathway (GO:0050853)3.01384102
52protein localization to kinetochore (GO:0034501)3.01106558
53nucleotide-excision repair, DNA gap filling (GO:0006297)3.00344696
54telomere organization (GO:0032200)2.98762214
55rRNA transcription (GO:0009303)2.98664286
56telomere maintenance (GO:0000723)2.97167327
57DNA synthesis involved in DNA repair (GO:0000731)2.96362119
58B cell proliferation (GO:0042100)2.91512714
59telomere maintenance via telomere lengthening (GO:0010833)2.90413846
60peptidyl-arginine N-methylation (GO:0035246)2.88190403
61peptidyl-arginine methylation (GO:0018216)2.88190403
62B cell mediated immunity (GO:0019724)2.88122882
63mitochondrial DNA metabolic process (GO:0032042)2.86731556
64protein complex localization (GO:0031503)2.78157669
65maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.77982403
66regulation of B cell apoptotic process (GO:0002902)2.77086050
67T cell lineage commitment (GO:0002360)2.72977501
68tongue development (GO:0043586)2.72516080
69positive regulation of chromosome segregation (GO:0051984)2.70613810
70translesion synthesis (GO:0019985)2.69541393
71cellular protein complex localization (GO:0034629)2.68019903
72somatic hypermutation of immunoglobulin genes (GO:0016446)2.67084425
73somatic diversification of immune receptors via somatic mutation (GO:0002566)2.67084425
74spliceosomal tri-snRNP complex assembly (GO:0000244)2.67010878
75pseudouridine synthesis (GO:0001522)2.66946409
76protein-DNA complex disassembly (GO:0032986)2.64908858
77nucleosome disassembly (GO:0006337)2.64908858
78ribosomal small subunit biogenesis (GO:0042274)2.64176607
79cellular response to UV (GO:0034644)2.62732264
80DNA replication-independent nucleosome organization (GO:0034724)2.61139356
81DNA replication-independent nucleosome assembly (GO:0006336)2.61139356
82DNA conformation change (GO:0071103)2.60066291
83regulation of centrosome cycle (GO:0046605)2.59727936
84regulation of mitochondrial translation (GO:0070129)2.59640088
85regulation of sister chromatid cohesion (GO:0007063)2.54685921
86double-strand break repair via nonhomologous end joining (GO:0006303)2.54352151
87non-recombinational repair (GO:0000726)2.54352151
88ATP-dependent chromatin remodeling (GO:0043044)2.53740270
89negative regulation of chromosome segregation (GO:0051985)2.53416113
90regulation of gene silencing (GO:0060968)2.52645592
91nucleobase-containing small molecule interconversion (GO:0015949)2.52410525
92regulation of chromosome segregation (GO:0051983)2.51715883
93mitochondrial RNA metabolic process (GO:0000959)2.49634803
94nuclear envelope organization (GO:0006998)2.49160753
95snRNA metabolic process (GO:0016073)2.48416517
96deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.46525482
97pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.46389086
98V(D)J recombination (GO:0033151)2.44861258
99pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.44835725
100innate immune response in mucosa (GO:0002227)10.9290892

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.64325900
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.78918269
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.58822562
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.33771737
5TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.00497732
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.90086919
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.60774700
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.58191397
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41605830
10SOX2_16153702_ChIP-ChIP_HESCs_Human2.16087536
11MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08959551
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.06568076
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse15.6231261
14MYC_18555785_ChIP-Seq_MESCs_Mouse1.95764204
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.95664717
16HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.95027639
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.91413976
18CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.88865958
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.83364455
20POU5F1_16153702_ChIP-ChIP_HESCs_Human1.79487137
21NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79118494
22VDR_21846776_ChIP-Seq_THP-1_Human1.77778439
23MYC_19030024_ChIP-ChIP_MESCs_Mouse1.75721867
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.72681493
25MYC_22102868_ChIP-Seq_BL_Human1.69399665
26ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66597742
27ERG_20887958_ChIP-Seq_HPC-7_Mouse1.54004225
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47926947
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44941632
30IRF1_19129219_ChIP-ChIP_H3396_Human1.42988591
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40960086
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38102314
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36763318
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35483237
35KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.31901039
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29661891
37XRN2_22483619_ChIP-Seq_HELA_Human1.26874005
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.25867149
39VDR_23849224_ChIP-Seq_CD4+_Human1.24760941
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24376404
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23740863
42SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.20908814
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20468131
44DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18603983
45CIITA_25753668_ChIP-Seq_RAJI_Human1.18520531
46KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18149757
47MAF_26560356_Chip-Seq_TH1_Human1.16066012
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15651601
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15602189
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10031454
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.07326370
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07310690
53NANOG_16153702_ChIP-ChIP_HESCs_Human1.06076100
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05216051
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03953667
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.03695617
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01272110
58AR_21909140_ChIP-Seq_LNCAP_Human1.01076545
59SOX2_18692474_ChIP-Seq_MESCs_Mouse1.00023618
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99237123
61DCP1A_22483619_ChIP-Seq_HELA_Human0.99079947
62VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98708153
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98291734
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97162368
65MYC_18940864_ChIP-ChIP_HL60_Human0.96284973
66FOXP3_21729870_ChIP-Seq_TREG_Human0.96182682
67NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94985562
68BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94542252
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91191833
70GATA1_22025678_ChIP-Seq_K562_Human0.91139698
71ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90797729
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90604762
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89642789
74ETS1_22383799_ChIP-Seq_G1ME_Mouse0.89309677
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.88818337
76PKCTHETA_26484144_Chip-Seq_BREAST_Human0.86711227
77ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86459357
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85225305
79ZNF263_19887448_ChIP-Seq_K562_Human0.84650477
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82535846
81TP63_17297297_ChIP-ChIP_HaCaT_Human0.80561531
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.78437036
83PADI4_21655091_ChIP-ChIP_MCF-7_Human0.78417931
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76663089
85ELK1_19687146_ChIP-ChIP_HELA_Human0.76071996
86YY1_21170310_ChIP-Seq_MESCs_Mouse0.75916216
87EST1_17652178_ChIP-ChIP_JURKAT_Human0.75814937
88GABP_19822575_ChIP-Seq_HepG2_Human0.74490516
89TTF2_22483619_ChIP-Seq_HELA_Human0.74191430
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.73934331
91KDM5A_27292631_Chip-Seq_BREAST_Human0.72421390
92MAF_26560356_Chip-Seq_TH2_Human0.70697410
93EGR1_19374776_ChIP-ChIP_THP-1_Human0.70624093
94MYB_26560356_Chip-Seq_TH1_Human0.70079114
95UTX_26944678_Chip-Seq_JUKART_Human0.69104896
96MYCN_18555785_ChIP-Seq_MESCs_Mouse0.68449567
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.67659412
98IRF8_22096565_ChIP-ChIP_GC-B_Human0.67648524
99PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.67428264
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.67188461

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.98359438
2MP0003111_abnormal_nucleus_morphology4.46539586
3MP0003077_abnormal_cell_cycle3.93991337
4MP0005645_abnormal_hypothalamus_physiol3.88397015
5MP0003693_abnormal_embryo_hatching3.86446469
6MP0008057_abnormal_DNA_replication3.58238476
7MP0000685_abnormal_immune_system3.26342760
8MP0004957_abnormal_blastocyst_morpholog3.03255951
9MP0003763_abnormal_thymus_physiology2.55259180
10MP0005671_abnormal_response_to2.37061335
11MP0002009_preneoplasia2.17052014
12MP0008932_abnormal_embryonic_tissue2.14555963
13MP0008007_abnormal_cellular_replicative2.10451201
14MP0008058_abnormal_DNA_repair2.09271823
15MP0001835_abnormal_antigen_presentation2.09197305
16MP0010352_gastrointestinal_tract_polyps2.08966447
17MP0000350_abnormal_cell_proliferation2.08041976
18MP0005623_abnormal_meninges_morphology2.06707707
19MP0002166_altered_tumor_susceptibility2.03488178
20MP0010307_abnormal_tumor_latency1.97091758
21MP0003786_premature_aging1.91191196
22MP0001800_abnormal_humoral_immune1.90172823
23MP0001661_extended_life_span1.86867878
24MP0010234_abnormal_vibrissa_follicle1.73454916
25MP0004185_abnormal_adipocyte_glucose1.73366347
26MP0002396_abnormal_hematopoietic_system1.72340673
27MP0000490_abnormal_crypts_of1.71834461
28MP0002398_abnormal_bone_marrow1.67750614
29MP0002019_abnormal_tumor_incidence1.59039289
30MP0002006_tumorigenesis1.56450995
31MP0005387_immune_system_phenotype1.54482677
32MP0001790_abnormal_immune_system1.54482677
33MP0001727_abnormal_embryo_implantation1.52407137
34MP0000537_abnormal_urethra_morphology1.52081599
35MP0000313_abnormal_cell_death1.50103340
36MP0005076_abnormal_cell_differentiation1.46524224
37MP0000703_abnormal_thymus_morphology1.46327158
38MP0002722_abnormal_immune_system1.44180079
39MP0002163_abnormal_gland_morphology1.39126501
40MP0004808_abnormal_hematopoietic_stem1.38862698
41MP0005000_abnormal_immune_tolerance1.34044584
42MP0002877_abnormal_melanocyte_morpholog1.33649004
43MP0001346_abnormal_lacrimal_gland1.33518991
44MP0005451_abnormal_body_composition1.30554482
45MP0001730_embryonic_growth_arrest1.30426990
46MP0000689_abnormal_spleen_morphology1.28320873
47MP0006035_abnormal_mitochondrial_morpho1.27027908
48MP0009697_abnormal_copulation1.24157157
49MP0002429_abnormal_blood_cell1.22592496
50MP0000716_abnormal_immune_system1.19611520
51MP0001849_ear_inflammation1.19461572
52MP0002080_prenatal_lethality1.18045654
53MP0005083_abnormal_biliary_tract1.17613929
54MP0002452_abnormal_antigen_presenting1.17509890
55MP0000358_abnormal_cell_content/1.17053879
56MP0005220_abnormal_exocrine_pancreas1.16927556
57MP0002420_abnormal_adaptive_immunity1.14363271
58MP0002723_abnormal_immune_serum1.12925147
59MP0005380_embryogenesis_phenotype1.11471735
60MP0001672_abnormal_embryogenesis/_devel1.11471735
61MP0009046_muscle_twitch1.10231861
62MP0001819_abnormal_immune_cell1.09731059
63MP0002086_abnormal_extraembryonic_tissu1.06356891
64MP0003984_embryonic_growth_retardation1.01559284
65MP0003183_abnormal_peptide_metabolism1.00111586
66MP0009333_abnormal_splenocyte_physiolog0.98960125
67MP0001697_abnormal_embryo_size0.96859364
68MP0002088_abnormal_embryonic_growth/wei0.96326587
69MP0005310_abnormal_salivary_gland0.94554642
70MP0004233_abnormal_muscle_weight0.90698625
71MP0003941_abnormal_skin_development0.88832516
72MP0000015_abnormal_ear_pigmentation0.87548232
73MP0002160_abnormal_reproductive_system0.86690376
74MP0000003_abnormal_adipose_tissue0.86646896
75MP0002085_abnormal_embryonic_tissue0.83852032
76MP0003303_peritoneal_inflammation0.81112019
77MP0005384_cellular_phenotype0.80498457
78MP0001348_abnormal_lacrimal_gland0.80288497
79MP0005621_abnormal_cell_physiology0.76907461
80MP0000013_abnormal_adipose_tissue0.76019658
81MP0002138_abnormal_hepatobiliary_system0.75727618
82MP0002084_abnormal_developmental_patter0.72806033
83MP0000747_muscle_weakness0.72041313
84MP0001873_stomach_inflammation0.70431156
85MP0003315_abnormal_perineum_morphology0.69218400
86MP0005025_abnormal_response_to0.67850336
87MP0003718_maternal_effect0.65176574
88MP0002111_abnormal_tail_morphology0.63754764
89MP0003705_abnormal_hypodermis_morpholog0.63041778
90MP0002210_abnormal_sex_determination0.62137575
91MP0000477_abnormal_intestine_morphology0.61730515
92MP0001919_abnormal_reproductive_system0.61213656
93MP0000733_abnormal_muscle_development0.60575268
94MP0000371_diluted_coat_color0.60568192
95MP0002092_abnormal_eye_morphology0.60560604
96MP0002697_abnormal_eye_size0.60073137
97MP0002083_premature_death0.59694120
98MP0000538_abnormal_urinary_bladder0.59017623
99MP0001845_abnormal_inflammatory_respons0.59004355
100MP0003699_abnormal_female_reproductive0.58753088

Predicted human phenotypes

RankGene SetZ-score
1IgA deficiency (HP:0002720)6.23128352
2IgM deficiency (HP:0002850)5.94042688
3Gastrointestinal stroma tumor (HP:0100723)5.77259983
4Chromosomal breakage induced by crosslinking agents (HP:0003221)5.22727643
5Chromsome breakage (HP:0040012)4.53623631
6Recurrent sinusitis (HP:0011108)4.29955034
7Squamous cell carcinoma (HP:0002860)4.23748378
8Colitis (HP:0002583)3.89266993
9Agammaglobulinemia (HP:0004432)3.86708083
10Recurrent bronchitis (HP:0002837)3.67016760
11Cellulitis (HP:0100658)3.65130772
12Lymphopenia (HP:0001888)3.51875845
13Dry hair (HP:0011359)3.47603490
14Abnormality of cells of the lymphoid lineage (HP:0012140)3.45004832
15Microvesicular hepatic steatosis (HP:0001414)3.31326105
16Emphysema (HP:0002097)3.08980300
17Onycholysis (HP:0001806)2.92069320
18Basal cell carcinoma (HP:0002671)2.91314732
19Aplasia/Hypoplasia of the sacrum (HP:0008517)2.85674870
20Abnormality of the preputium (HP:0100587)2.80045680
21Aplasia/Hypoplasia of the uvula (HP:0010293)2.74353458
22Abnormality of chromosome stability (HP:0003220)2.71472632
23Meningitis (HP:0001287)2.69078734
24Reticulocytopenia (HP:0001896)2.65110485
25Birth length less than 3rd percentile (HP:0003561)2.65102819
26Abnormality of the ileum (HP:0001549)2.64766916
27Leukopenia (HP:0001882)2.62436542
28IgG deficiency (HP:0004315)2.53864520
29Progressive muscle weakness (HP:0003323)2.53278249
30B lymphocytopenia (HP:0010976)2.51996464
31Lymphoma (HP:0002665)2.48604744
32Meckel diverticulum (HP:0002245)2.46519142
33Recurrent pneumonia (HP:0006532)2.43258660
34Chronic diarrhea (HP:0002028)2.41689036
35Abnormality of DNA repair (HP:0003254)2.39028512
36Abnormality of the carotid arteries (HP:0005344)2.33355769
37Recurrent lower respiratory tract infections (HP:0002783)2.31521026
38Erythema (HP:0010783)2.27952297
39Breast hypoplasia (HP:0003187)2.27014180
40Ridged nail (HP:0001807)2.22341749
41Abnormal gallbladder physiology (HP:0012438)2.21227248
42Cholecystitis (HP:0001082)2.21227248
43Recurrent viral infections (HP:0004429)2.20862295
44Abnormality of T cell physiology (HP:0011840)2.20046448
45Inflammation of the large intestine (HP:0002037)2.16761658
46Ureteral duplication (HP:0000073)2.13324591
47Prostate neoplasm (HP:0100787)2.13167979
48Broad distal phalanx of finger (HP:0009836)2.12721844
49Gastrointestinal inflammation (HP:0004386)2.12283370
50Ragged-red muscle fibers (HP:0003200)2.11826794
51Hepatitis (HP:0012115)2.09785828
52Clubbing of toes (HP:0100760)2.04837326
53Lipid accumulation in hepatocytes (HP:0006561)2.04534515
54Vasculitis (HP:0002633)2.04375774
55Acute lymphatic leukemia (HP:0006721)2.03800601
56Short thumb (HP:0009778)2.03267167
57Urticaria (HP:0001025)2.03108408
58Osteomyelitis (HP:0002754)2.02485306
59Medulloblastoma (HP:0002885)2.02176797
60Abnormality of pyrimidine metabolism (HP:0004353)2.01514208
61Hypergonadotropic hypogonadism (HP:0000815)2.00625502
62Abnormality of B cell number (HP:0010975)1.99933776
63Orthostatic hypotension (HP:0001278)1.98259019
64Abnormality of cells of the erythroid lineage (HP:0012130)1.97806963
65Septate vagina (HP:0001153)1.96987769
66Hyperacusis (HP:0010780)1.93998861
67Abnormal number of erythroid precursors (HP:0012131)1.93070604
68Mediastinal lymphadenopathy (HP:0100721)1.92881731
69Entropion (HP:0000621)1.92116512
70Conical tooth (HP:0000698)1.91595016
7111 pairs of ribs (HP:0000878)1.91490856
72Duplicated collecting system (HP:0000081)1.88586803
73Hypoplasia of the pons (HP:0012110)1.88121145
74Viral hepatitis (HP:0006562)1.86152181
75Increased muscle lipid content (HP:0009058)1.85653454
76Abnormality of cochlea (HP:0000375)1.84475533
77Poikiloderma (HP:0001029)1.84191760
78Nephroblastoma (Wilms tumor) (HP:0002667)1.83726249
79Cleft eyelid (HP:0000625)1.80884118
80Abnormality of the prostate (HP:0008775)1.80789529
81Micronodular cirrhosis (HP:0001413)1.80733698
82Small intestinal stenosis (HP:0012848)1.79814470
83Duodenal stenosis (HP:0100867)1.79814470
84Recurrent bacterial skin infections (HP:0005406)1.79625285
85Restrictive lung disease (HP:0002091)1.79373125
86Absent thumb (HP:0009777)1.76142961
87Reduced antithrombin III activity (HP:0001976)1.75488075
88Bronchitis (HP:0012387)1.74855050
89Recurrent otitis media (HP:0000403)1.72994837
90Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.71221580
91Increased intramyocellular lipid droplets (HP:0012240)1.71081766
92Abnormality of the fingertips (HP:0001211)1.70971728
93Panhypogammaglobulinemia (HP:0003139)1.69161679
94Spastic diplegia (HP:0001264)1.69129579
95Cafe-au-lait spot (HP:0000957)1.68783525
96Asymmetry of the thorax (HP:0001555)1.68215749
97Abnormality of incisor morphology (HP:0011063)1.66964623
98Abnormality of glycolysis (HP:0004366)1.66567888
99Embryonal renal neoplasm (HP:0011794)1.65695966
100Deep palmar crease (HP:0006191)1.65443682

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK9.09761049
2TLK18.80461752
3VRK15.78557608
4RPS6KA53.39605462
5DAPK32.99536044
6SMG12.37897319
7AURKA2.30190153
8BUB12.13531598
9STK41.68630086
10CDC71.68040307
11EEF2K1.62814018
12TRIB31.59127355
13NME21.36778012
14CHEK21.36529776
15AURKB1.25626321
16PKN11.21524203
17TAF11.20651571
18PIM11.19447695
19BCKDK1.04615315
20ICK1.04264393
21MAP3K101.00275600
22IRAK40.88223910
23SCYL20.84634406
24SRPK10.83704893
25RPS6KB20.81114851
26PBK0.79666806
27NEK10.78734122
28MAP3K80.75319571
29BRAF0.73415668
30ATR0.73352575
31TTK0.73272005
32MAPK110.68825282
33BLK0.68607878
34VRK20.68271484
35AKT20.68265938
36ARAF0.67290346
37PIM20.60749690
38CDK80.60467209
39CDK70.56365509
40KDR0.54205246
41CDK120.54091860
42STK160.53970505
43MAP4K10.52890920
44BTK0.52254809
45PKN20.51880517
46CCNB10.51873961
47CSNK1G30.50642087
48IRAK30.48958582
49PLK10.47758896
50CSNK1A1L0.46904629
51MAP2K70.45577482
52MELK0.41026894
53PRKCQ0.40705019
54WEE10.40590840
55NEK90.39687653
56CDK40.39671367
57MAPKAPK50.39456734
58PRKAA10.39197206
59CHEK10.38957215
60CSNK1G10.37100999
61SYK0.36881815
62BRSK20.36098055
63TBK10.32414314
64MAP2K30.32168435
65EIF2AK30.31416093
66PAK10.30456553
67IKBKB0.27530381
68NEK20.26963027
69PRPF4B0.26910500
70CDK20.24409733
71MAP3K90.24397579
72ATM0.23354866
73FGFR40.23254439
74LYN0.22792635
75CDK90.20558062
76TSSK60.20240409
77MAP3K130.19575133
78CDK60.19524200
79MAP3K140.19489534
80CSNK1G20.19226650
81BRSK10.19127422
82RAF10.18876556
83TESK20.18534187
84PLK40.17933950
85JAK20.15300990
86CDK10.14824187
87TTN0.12342146
88MAPK120.12338838
89PRKCD0.12293275
90CAMK40.11998138
91MAP2K20.11698503
92MTOR0.11286481
93IKBKE0.09637587
94RPS6KB10.09386429
95PRKCI0.09216934
96CAMK1D0.08870061
97PDK20.08320734
98SIK10.07738283
99RPS6KA10.07575860
100STK100.06013465

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050347.74669982
2Viral carcinogenesis_Homo sapiens_hsa052033.37836416
3DNA replication_Homo sapiens_hsa030302.62895638
4* Systemic lupus erythematosus_Homo sapiens_hsa0532211.1643980
5Intestinal immune network for IgA production_Homo sapiens_hsa046721.70264164
6* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.70090745
7Primary immunodeficiency_Homo sapiens_hsa053401.55741398
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.55569156
9Mismatch repair_Homo sapiens_hsa034301.55484339
10Sulfur relay system_Homo sapiens_hsa041221.43628324
11Allograft rejection_Homo sapiens_hsa053301.41567696
12Asthma_Homo sapiens_hsa053101.40413082
13Autoimmune thyroid disease_Homo sapiens_hsa053201.31497805
14Base excision repair_Homo sapiens_hsa034101.27126702
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24723042
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19806353
17Cell cycle_Homo sapiens_hsa041101.12237922
18Graft-versus-host disease_Homo sapiens_hsa053321.09743149
19Homologous recombination_Homo sapiens_hsa034401.07361575
20Fanconi anemia pathway_Homo sapiens_hsa034601.03466527
21Nucleotide excision repair_Homo sapiens_hsa034200.99140839
22Viral myocarditis_Homo sapiens_hsa054160.95668361
23Type I diabetes mellitus_Homo sapiens_hsa049400.95362570
24Biosynthesis of amino acids_Homo sapiens_hsa012300.93327553
25B cell receptor signaling pathway_Homo sapiens_hsa046620.92061833
26Non-homologous end-joining_Homo sapiens_hsa034500.90226528
27Pentose phosphate pathway_Homo sapiens_hsa000300.88774062
28Pyrimidine metabolism_Homo sapiens_hsa002400.80044646
29Fructose and mannose metabolism_Homo sapiens_hsa000510.76212572
30Ribosome_Homo sapiens_hsa030100.74938646
31Vitamin B6 metabolism_Homo sapiens_hsa007500.72062411
32Spliceosome_Homo sapiens_hsa030400.67411985
33Antigen processing and presentation_Homo sapiens_hsa046120.65300870
34Epstein-Barr virus infection_Homo sapiens_hsa051690.64780269
35p53 signaling pathway_Homo sapiens_hsa041150.64684718
36Herpes simplex infection_Homo sapiens_hsa051680.61281984
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60680980
38One carbon pool by folate_Homo sapiens_hsa006700.59132991
39HTLV-I infection_Homo sapiens_hsa051660.58034949
40RNA transport_Homo sapiens_hsa030130.57690553
41Carbon metabolism_Homo sapiens_hsa012000.56134501
42Leishmaniasis_Homo sapiens_hsa051400.55865647
43Central carbon metabolism in cancer_Homo sapiens_hsa052300.51020773
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48839774
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47262926
46Galactose metabolism_Homo sapiens_hsa000520.42995511
47Selenocompound metabolism_Homo sapiens_hsa004500.42579771
48RNA polymerase_Homo sapiens_hsa030200.40990179
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37362206
50Influenza A_Homo sapiens_hsa051640.36915351
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36429416
52Non-small cell lung cancer_Homo sapiens_hsa052230.36386275
53Bladder cancer_Homo sapiens_hsa052190.35397503
54Purine metabolism_Homo sapiens_hsa002300.34476716
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.34439458
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33218255
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31992371
58Proteasome_Homo sapiens_hsa030500.31564848
59Phenylalanine metabolism_Homo sapiens_hsa003600.30924742
60Apoptosis_Homo sapiens_hsa042100.30683853
61N-Glycan biosynthesis_Homo sapiens_hsa005100.26412133
62Hepatitis B_Homo sapiens_hsa051610.25839532
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23716675
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23626720
65Basal cell carcinoma_Homo sapiens_hsa052170.23402599
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.23241783
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.23165125
68Pancreatic cancer_Homo sapiens_hsa052120.23084691
69Chronic myeloid leukemia_Homo sapiens_hsa052200.21612309
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21331357
71RNA degradation_Homo sapiens_hsa030180.21244095
72Thyroid cancer_Homo sapiens_hsa052160.20284162
73mRNA surveillance pathway_Homo sapiens_hsa030150.20185019
74Pyruvate metabolism_Homo sapiens_hsa006200.19959611
75Toxoplasmosis_Homo sapiens_hsa051450.17819439
76Colorectal cancer_Homo sapiens_hsa052100.17769763
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17419950
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17277339
79Measles_Homo sapiens_hsa051620.16376807
80Small cell lung cancer_Homo sapiens_hsa052220.16152246
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.15965001
82Glioma_Homo sapiens_hsa052140.15558274
83Acute myeloid leukemia_Homo sapiens_hsa052210.15347179
84MicroRNAs in cancer_Homo sapiens_hsa052060.14437067
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13695524
86Staphylococcus aureus infection_Homo sapiens_hsa051500.13670603
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.13221846
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.11376804
89Hematopoietic cell lineage_Homo sapiens_hsa046400.09551197
90Lysine degradation_Homo sapiens_hsa003100.09162965
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.08844912
92HIF-1 signaling pathway_Homo sapiens_hsa040660.07277779
93Huntingtons disease_Homo sapiens_hsa050160.07261934
94Oocyte meiosis_Homo sapiens_hsa041140.07189838
95Parkinsons disease_Homo sapiens_hsa050120.04605450
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.04346443
97Tuberculosis_Homo sapiens_hsa051520.03807596
98Inositol phosphate metabolism_Homo sapiens_hsa005620.03133289
99Prostate cancer_Homo sapiens_hsa052150.03016719
100Endometrial cancer_Homo sapiens_hsa052130.02832472

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