HIST2H3PS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration involved in heart development (GO:0060973)6.22486639
2negative regulation of chondrocyte differentiation (GO:0032331)6.03099149
3regulation of secondary heart field cardioblast proliferation (GO:0003266)5.85796913
4regulation of cardioblast proliferation (GO:0003264)5.85796913
5peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.85076029
6collagen fibril organization (GO:0030199)5.72837362
7basement membrane organization (GO:0071711)5.70146369
8negative regulation of gluconeogenesis (GO:0045721)5.45877945
9positive regulation of catecholamine secretion (GO:0033605)4.73879430
10negative regulation of biomineral tissue development (GO:0070168)4.72801449
11negative regulation of cartilage development (GO:0061037)4.61387864
12response to peptidoglycan (GO:0032494)4.59580301
13keratan sulfate catabolic process (GO:0042340)4.42944266
14regulation of phospholipase A2 activity (GO:0032429)4.40023294
15negative regulation of cardiac muscle tissue growth (GO:0055022)4.38336083
16negative regulation of heart growth (GO:0061117)4.38336083
17negative regulation of chemokine production (GO:0032682)4.33519781
18ribosomal small subunit biogenesis (GO:0042274)4.32543779
19regulation of interleukin-6 biosynthetic process (GO:0045408)4.31850123
20skin morphogenesis (GO:0043589)4.30549957
21dermatan sulfate biosynthetic process (GO:0030208)4.28434967
22regulation of cardioblast differentiation (GO:0051890)4.18449719
23endocardial cushion development (GO:0003197)4.15514983
24regulation of organ formation (GO:0003156)3.98294901
25dermatan sulfate metabolic process (GO:0030205)3.89008127
26estrogen biosynthetic process (GO:0006703)3.87961134
27bone trabecula formation (GO:0060346)3.84627190
28mesenchymal-epithelial cell signaling (GO:0060638)3.84078043
29extracellular fibril organization (GO:0043206)3.75500785
30chondrocyte development (GO:0002063)3.69884400
31histone H3-K36 demethylation (GO:0070544)3.67878530
32negative regulation of cardiac muscle tissue development (GO:0055026)3.66329483
33regulation of gonadotropin secretion (GO:0032276)3.64186967
34protein heterotrimerization (GO:0070208)3.60317266
35atrioventricular valve morphogenesis (GO:0003181)3.50529170
36middle ear morphogenesis (GO:0042474)3.41681240
37regulation of chondrocyte differentiation (GO:0032330)3.41476712
38fibril organization (GO:0097435)3.41369323
39mRNA cleavage (GO:0006379)3.40262886
40hyaluronan catabolic process (GO:0030214)3.39861431
41negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.38457852
42negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.35427867
43regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.34908976
44organ induction (GO:0001759)3.34546233
45response to muramyl dipeptide (GO:0032495)3.32704364
46negative regulation of NF-kappaB import into nucleus (GO:0042347)3.27176708
47regulation of heart morphogenesis (GO:2000826)3.26914688
48regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.26801861
49regulation of cartilage development (GO:0061035)3.24332762
50defense response to protozoan (GO:0042832)3.21294589
51chondroitin sulfate catabolic process (GO:0030207)3.18985514
52regulation of vesicle fusion (GO:0031338)3.17430308
53kidney mesenchyme development (GO:0072074)3.14401527
54negative regulation of defense response to virus (GO:0050687)3.14102521
55positive regulation of osteoblast proliferation (GO:0033690)3.09549604
56collagen catabolic process (GO:0030574)3.07794401
57collagen metabolic process (GO:0032963)3.07343338
58extracellular matrix disassembly (GO:0022617)3.06729178
59negative regulation of fatty acid transport (GO:2000192)3.04137834
60UV protection (GO:0009650)3.00418755
61endodermal cell differentiation (GO:0035987)3.00296791
62barbed-end actin filament capping (GO:0051016)2.99881407
63response to protozoan (GO:0001562)2.97532749
64tooth mineralization (GO:0034505)2.92332210
65regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.90357800
66replacement ossification (GO:0036075)2.89960582
67endochondral ossification (GO:0001958)2.89960582
68negative regulation of smooth muscle cell proliferation (GO:0048662)2.87374904
69negative regulation of macrophage differentiation (GO:0045650)2.85940959
70cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.85259853
71embryonic skeletal system development (GO:0048706)2.84114322
72multicellular organismal macromolecule metabolic process (GO:0044259)2.83117222
73embryonic forelimb morphogenesis (GO:0035115)2.82081758
74cartilage development (GO:0051216)2.82035050
75outer ear morphogenesis (GO:0042473)2.80994528
76positive regulation of cartilage development (GO:0061036)2.79868011
77response to UV-B (GO:0010224)2.79197348
78organ formation (GO:0048645)2.77844693
79regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.77664853
80positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.77042490
81positive regulation of protein import into nucleus, translocation (GO:0033160)2.76933553
82protein retention in ER lumen (GO:0006621)2.76532958
83cranial nerve morphogenesis (GO:0021602)2.76173253
84chondroitin sulfate biosynthetic process (GO:0030206)2.74908092
85multicellular organismal catabolic process (GO:0044243)2.74273887
86protein localization to cell surface (GO:0034394)2.74165517
87cardiac ventricle formation (GO:0003211)2.73147611
88ubiquinone biosynthetic process (GO:0006744)2.69845800
89positive regulation of megakaryocyte differentiation (GO:0045654)2.69406921
90negative regulation of T cell differentiation in thymus (GO:0033085)2.68836960
91forelimb morphogenesis (GO:0035136)2.68251783
92regulation of retinoic acid receptor signaling pathway (GO:0048385)2.66409809
93regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.65550275
94positive regulation of blood vessel endothelial cell migration (GO:0043536)2.64886647
95multicellular organismal metabolic process (GO:0044236)2.63991966
96coenzyme catabolic process (GO:0009109)2.61405420
97metanephric mesenchyme development (GO:0072075)2.59158346
98blood vessel remodeling (GO:0001974)2.58397204
99cardiac chamber formation (GO:0003207)2.57271379
100sulfur compound catabolic process (GO:0044273)2.56703737

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.59981493
2E2F7_22180533_ChIP-Seq_HELA_Human2.99264296
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.95351098
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.38362967
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.37357221
6TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.34973708
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34953039
8ESR1_15608294_ChIP-ChIP_MCF-7_Human2.23427621
9HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.22342995
10CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.21939317
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.14039913
12RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.12346061
13BRD4_25478319_ChIP-Seq_HGPS_Human2.02011162
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse13.3732478
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.89585078
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.85453119
17AR_21909140_ChIP-Seq_LNCAP_Human1.84304858
18FOXM1_23109430_ChIP-Seq_U2OS_Human1.80697830
19VDR_24763502_ChIP-Seq_THP-1_Human1.77322882
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77028380
21VDR_21846776_ChIP-Seq_THP-1_Human1.72678065
22WDR5_24793694_ChIP-Seq_LNCAP_Human1.65264601
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.61402837
24CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.58244453
25* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47892253
26TP63_17297297_ChIP-ChIP_HaCaT_Human1.47124749
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.45637147
28CJUN_26792858_Chip-Seq_BT549_Human1.45489116
29VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.44624432
30ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.42891779
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39687151
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37957223
33CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37242762
34ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.35809693
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31426619
36* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31105344
37* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31105344
38ZNF263_19887448_ChIP-Seq_K562_Human1.30328083
39HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.27242115
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.27017726
41LXR_22292898_ChIP-Seq_THP-1_Human1.20395766
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17677980
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17609173
44NFI_21473784_ChIP-Seq_ESCs_Mouse1.15946368
45CTCF_21964334_Chip-Seq_Bcells_Human1.15843416
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.15253866
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.14776576
48ELF1_20517297_ChIP-Seq_JURKAT_Human1.14361108
49JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12563048
50TP53_23651856_ChIP-Seq_MEFs_Mouse1.12080770
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10548613
52KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08661339
53KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08661339
54KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08661339
55UBF1/2_26484160_Chip-Seq_HMECs_Human1.08338647
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08223144
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07794379
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06479710
59ATF3_27146783_Chip-Seq_COLON_Human1.05835810
60SMC4_20622854_ChIP-Seq_HELA_Human1.05003808
61NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03258969
62CTCF_21964334_ChIP-Seq_BJAB-B_Human1.02746242
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02077320
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00108485
65RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98915008
66P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98764709
67VDR_24787735_ChIP-Seq_THP-1_Human0.98354475
68SMC1_22415368_ChIP-Seq_MEFs_Mouse0.96209125
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95419325
70CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94407357
71SPI1_20517297_ChIP-Seq_HL60_Human0.92442181
72FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.91828918
73CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91811005
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88996937
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88881839
76UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87536338
77EED_16625203_ChIP-ChIP_MESCs_Mouse0.87151595
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86395182
79SCL_19346495_ChIP-Seq_HPC-7_Human0.85611250
80SA1_22415368_ChIP-Seq_MEFs_Mouse0.85486423
81AR_21572438_ChIP-Seq_LNCaP_Human0.85103387
82CSB_26484114_Chip-Seq_FIBROBLAST_Human0.82839352
83JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82334021
84SMC3_22415368_ChIP-Seq_MEFs_Mouse0.82127867
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81682662
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81160565
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80950345
88STAT1_20625510_ChIP-Seq_HELA_Human0.79710892
89RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.79519525
90STAT1_17558387_ChIP-Seq_HELA_Human0.78831079
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78393801
92TP53_22127205_ChIP-Seq_IMR90_Human0.78312339
93TP63_22573176_ChIP-Seq_HFKS_Human0.76782469
94RAC3_21632823_ChIP-Seq_H3396_Human0.76176482
95SA1_27219007_Chip-Seq_ERYTHROID_Human0.75619203
96PHF8_20622854_ChIP-Seq_HELA_Human0.75175279
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74702775
98STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.71842249
99TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.71661887
100P68_20966046_ChIP-Seq_HELA_Human0.71038804

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology8.11878952
2MP0008438_abnormal_cutaneous_collagen7.03204828
3MP0005275_abnormal_skin_tensile5.81117836
4MP0003283_abnormal_digestive_organ4.33721466
5MP0004134_abnormal_chest_morphology3.46856794
6MP0003705_abnormal_hypodermis_morpholog3.30814529
7MP0002108_abnormal_muscle_morphology2.82119268
8MP0004272_abnormal_basement_membrane2.74298442
9MP0005508_abnormal_skeleton_morphology2.67129363
10MP0001542_abnormal_bone_strength2.64895114
11MP0005257_abnormal_intraocular_pressure2.25105679
12MP0009250_abnormal_appendicular_skeleto2.23096002
13MP0001958_emphysema2.20511875
14MP0002254_reproductive_system_inflammat2.01032048
15MP0003279_aneurysm2.00652623
16MP0002060_abnormal_skin_morphology1.94099534
17MP0005023_abnormal_wound_healing1.83330114
18MP0008260_abnormal_autophagy1.83018202
19MP0001243_abnormal_dermal_layer1.70847415
20MP0009384_cardiac_valve_regurgitation1.70163988
21MP0000762_abnormal_tongue_morphology1.64054466
22MP0001348_abnormal_lacrimal_gland1.61580753
23MP0005171_absent_coat_pigmentation1.60599621
24MP0003950_abnormal_plasma_membrane1.56926170
25MP0005390_skeleton_phenotype1.50641814
26MP0000462_abnormal_digestive_system1.47698866
27MP0000749_muscle_degeneration1.47556100
28MP0010030_abnormal_orbit_morphology1.43905707
29MP0010368_abnormal_lymphatic_system1.43789519
30MP0010352_gastrointestinal_tract_polyps1.41508752
31MP0001849_ear_inflammation1.37158621
32MP0002163_abnormal_gland_morphology1.31010497
33MP0002282_abnormal_trachea_morphology1.30692192
34MP0000015_abnormal_ear_pigmentation1.28104970
35MP0003136_yellow_coat_color1.19725384
36MP0004883_abnormal_blood_vessel1.19610612
37MP0003786_premature_aging1.16880299
38MP0003566_abnormal_cell_adhesion1.16464212
39MP0000049_abnormal_middle_ear1.15577828
40MP0006054_spinal_hemorrhage1.13001576
41MP0010386_abnormal_urinary_bladder1.10790166
42MP0003385_abnormal_body_wall1.10264628
43MP0000163_abnormal_cartilage_morphology1.09653682
44MP0001270_distended_abdomen1.07994897
45MP0000534_abnormal_ureter_morphology1.07544880
46MP0002896_abnormal_bone_mineralization1.04780174
47MP0003448_altered_tumor_morphology1.02483635
48MP0005623_abnormal_meninges_morphology1.01185423
49MP0005164_abnormal_response_to0.96542274
50MP0000733_abnormal_muscle_development0.95350123
51MP0002115_abnormal_skeleton_extremities0.94014745
52MP0003091_abnormal_cell_migration0.92695144
53MP0002113_abnormal_skeleton_development0.92107819
54MP0001299_abnormal_eye_distance/0.91048331
55MP0002998_abnormal_bone_remodeling0.88099184
56MP0000013_abnormal_adipose_tissue0.85194598
57MP0000470_abnormal_stomach_morphology0.82099941
58MP0005595_abnormal_vascular_smooth0.80358668
59MP0002114_abnormal_axial_skeleton0.79431338
60MP0003941_abnormal_skin_development0.79284845
61MP0002295_abnormal_pulmonary_circulatio0.76490959
62MP0000537_abnormal_urethra_morphology0.76241371
63MP0000678_abnormal_parathyroid_gland0.75370384
64MP0001661_extended_life_span0.75277087
65MP0000613_abnormal_salivary_gland0.74433857
66MP0008004_abnormal_stomach_pH0.72309861
67MP0002111_abnormal_tail_morphology0.71475747
68MP0003315_abnormal_perineum_morphology0.68160388
69MP0003111_abnormal_nucleus_morphology0.67300477
70MP0003795_abnormal_bone_structure0.67262473
71MP0003935_abnormal_craniofacial_develop0.66175097
72MP0000747_muscle_weakness0.65544805
73MP0001879_abnormal_lymphatic_vessel0.63383177
74MP0002160_abnormal_reproductive_system0.62883645
75MP0004084_abnormal_cardiac_muscle0.62118595
76MP0009379_abnormal_foot_pigmentation0.61946536
77MP0010307_abnormal_tumor_latency0.61675134
78MP0000467_abnormal_esophagus_morphology0.60553143
79MP0002109_abnormal_limb_morphology0.59249522
80MP0002132_abnormal_respiratory_system0.58428345
81MP0001533_abnormal_skeleton_physiology0.54858850
82MP0003937_abnormal_limbs/digits/tail_de0.54551372
83MP0000750_abnormal_muscle_regeneration0.54508859
84MP0000767_abnormal_smooth_muscle0.51893296
85MP0000858_altered_metastatic_potential0.51807911
86MP0000372_irregular_coat_pigmentation0.50963745
87MP0003942_abnormal_urinary_system0.50887546
88MP0000432_abnormal_head_morphology0.50558954
89MP0002116_abnormal_craniofacial_bone0.50367822
90MP0000681_abnormal_thyroid_gland0.50344153
91MP0005174_abnormal_tail_pigmentation0.50262934
92MP0003300_gastrointestinal_ulcer0.49445251
93MP0005621_abnormal_cell_physiology0.49035919
94MP0005646_abnormal_pituitary_gland0.48058262
95MP0000759_abnormal_skeletal_muscle0.48016835
96MP0002932_abnormal_joint_morphology0.47857512
97MP0000627_abnormal_mammary_gland0.47619117
98MP0002177_abnormal_outer_ear0.46789734
99MP0000538_abnormal_urinary_bladder0.45571844
100MP0005197_abnormal_uvea_morphology0.45390626

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.46306535
2Aortic aneurysm (HP:0004942)5.32005615
3Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)4.89752285
4Protrusio acetabuli (HP:0003179)4.68426556
5Anomalous pulmonary venous return (HP:0010772)4.32905201
6Absent frontal sinuses (HP:0002688)4.25878096
7Abnormality of the frontal sinuses (HP:0002687)4.24451589
8Abnormality of the pulmonary veins (HP:0011718)3.92033460
9Aortic dissection (HP:0002647)3.89878377
10Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.88238722
11Spondylolisthesis (HP:0003302)3.87644283
12Ulnar bowing (HP:0003031)3.80039451
13Wrist flexion contracture (HP:0001239)3.78188697
14Partial duplication of the phalanx of hand (HP:0009999)3.61225026
15Mitral stenosis (HP:0001718)3.35646021
16Progressive muscle weakness (HP:0003323)3.31257900
17Soft skin (HP:0000977)3.28620991
18Aplasia/Hypoplasia of the sacrum (HP:0008517)3.22321946
19Osteolytic defects of the hand bones (HP:0009699)3.18027007
20Osteolytic defects of the phalanges of the hand (HP:0009771)3.18027007
21Aplasia of the musculature (HP:0100854)3.17651863
22Recurrent cutaneous fungal infections (HP:0011370)3.14100064
23Chronic mucocutaneous candidiasis (HP:0002728)3.14100064
24Genu recurvatum (HP:0002816)3.11769624
25Mild short stature (HP:0003502)3.08506760
26Cheilitis (HP:0100825)3.06040768
27Partial duplication of thumb phalanx (HP:0009944)3.01085074
28Aortic valve stenosis (HP:0001650)2.98841270
29Vitreoretinal degeneration (HP:0000655)2.97982238
30Radial bowing (HP:0002986)2.95334494
31Atrophic scars (HP:0001075)2.89606962
32Hypoplastic left heart (HP:0004383)2.89429197
33Wormian bones (HP:0002645)2.84370802
34Generalized amyotrophy (HP:0003700)2.72500245
35Shallow orbits (HP:0000586)2.72343546
36Dilatation of the ascending aorta (HP:0005111)2.71405392
37Metaphyseal dysplasia (HP:0100255)2.69022994
38Neonatal short-limb short stature (HP:0008921)2.64339023
39Absent rod-and cone-mediated responses on ERG (HP:0007688)2.62905262
40Aplastic anemia (HP:0001915)2.62256152
41Round ear (HP:0100830)2.61753475
42Blue sclerae (HP:0000592)2.59295373
43Bladder diverticulum (HP:0000015)2.58580528
44Short middle phalanx of the 5th finger (HP:0004220)2.56327344
45Abnormality of dentin (HP:0010299)2.55677713
46Delayed closure of the anterior fontanelle (HP:0001476)2.54056980
47Spinal rigidity (HP:0003306)2.48288533
48Cardiovascular calcification (HP:0011915)2.47001200
49Wide anterior fontanel (HP:0000260)2.45035725
50Cupped ribs (HP:0000887)2.42546753
51Fragile skin (HP:0001030)2.41127350
52Delayed cranial suture closure (HP:0000270)2.40322610
53Bowing of the arm (HP:0006488)2.36657517
54Bowed forearm bones (HP:0003956)2.36657517
55Small epiphyses (HP:0010585)2.32938240
56Persistence of primary teeth (HP:0006335)2.31279248
57Ankle contracture (HP:0006466)2.28545737
58Tibial bowing (HP:0002982)2.26619715
59Hypoventilation (HP:0002791)2.26278750
60Bowel diverticulosis (HP:0005222)2.25079415
61Metaphyseal cupping (HP:0003021)2.23333582
62Nonimmune hydrops fetalis (HP:0001790)2.22301874
63Follicular hyperkeratosis (HP:0007502)2.20357293
64Mitral valve prolapse (HP:0001634)2.17376499
65Hypoplastic heart (HP:0001961)2.17039703
66Ectopia lentis (HP:0001083)2.14304770
67Duplication of thumb phalanx (HP:0009942)2.11760007
68Thoracolumbar scoliosis (HP:0002944)2.10754832
69Flattened epiphyses (HP:0003071)2.08849452
70Irregular vertebral endplates (HP:0003301)2.08035954
71Absent thumb (HP:0009777)2.06479754
72Abnormality of the tricuspid valve (HP:0001702)2.05844086
73Coxa vara (HP:0002812)2.04517883
74Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.03323971
75Abnormality of the shoulder girdle musculature (HP:0001435)2.01818349
76Abnormality of oral frenula (HP:0000190)2.00894233
77Fibular hypoplasia (HP:0003038)1.99833024
78Aortic regurgitation (HP:0001659)1.96053541
79Biconcave vertebral bodies (HP:0004586)1.95648563
80Joint stiffness (HP:0001387)1.94487938
81Sensory axonal neuropathy (HP:0003390)1.92803772
82Cerebral aneurysm (HP:0004944)1.89774901
83Peritonitis (HP:0002586)1.88921146
84Ankyloglossia (HP:0010296)1.88473638
85Hyperextensible skin (HP:0000974)1.86588596
86Breech presentation (HP:0001623)1.84274598
87Vascular tortuosity (HP:0004948)1.84026635
88Disproportionate tall stature (HP:0001519)1.83047323
89Abnormality of the acetabulum (HP:0003170)1.81574921
90Arthropathy (HP:0003040)1.81446935
91Vertebral hypoplasia (HP:0008417)1.79445942
92Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.79445942
93Delayed gross motor development (HP:0002194)1.78599777
94Femoral bowing (HP:0002980)1.78242134
95Aplasia/Hypoplasia of the fibula (HP:0006492)1.76937251
96Abnormality of the columella (HP:0009929)1.76218875
97High pitched voice (HP:0001620)1.74441208
98Arterial tortuosity (HP:0005116)1.72830574
99Aplasia/Hypoplasia involving the musculature (HP:0001460)1.72035416
100Long eyelashes (HP:0000527)1.71149171

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.32199883
2ZAK4.28750970
3STK164.19507255
4MARK33.14454905
5BUB13.12568552
6MYLK3.11290256
7LATS12.75592124
8VRK12.38578797
9LMTK22.16544368
10ICK2.15958990
11LATS22.14044256
12PINK12.12557365
13NEK22.05250496
14MAP2K71.99269577
15SMG11.92667199
16TGFBR21.85896181
17AKT31.72421907
18EEF2K1.59717976
19PAK21.57843331
20PRKG21.49848445
21TRIB31.46607647
22IRAK31.46096572
23ABL21.36027762
24NME21.32547596
25MOS1.32235895
26ERN11.26304070
27DAPK31.22173996
28TIE11.20361341
29PKN21.13984638
30PDGFRA1.13913457
31DYRK31.13861007
32RPS6KA51.12604165
33STK38L1.10857087
34ILK1.06952333
35VRK21.05770298
36PKN11.05248526
37TRPM71.02817338
38CDK81.01330513
39PTK21.00827561
40MAP3K60.97080452
41SGK2230.92359767
42SGK4940.92359767
43MAPK150.91860205
44RPS6KA40.91250745
45EPHA20.90920550
46SGK20.87492553
47NEK90.85014697
48CDC70.83667432
49RET0.82846227
50PAK40.79366737
51MAPKAPK50.78828398
52CHEK20.76730338
53STK30.75927247
54AURKA0.75232912
55PBK0.74517919
56AURKB0.74032481
57PRKD20.71993229
58SGK30.71722723
59PAK10.71228441
60RIPK10.69537268
61FLT30.67344954
62EIF2AK30.66785724
63MET0.65252858
64ADRBK10.63914513
65BLK0.61085518
66CDC42BPA0.61073145
67MTOR0.60220181
68MST1R0.60055845
69ROCK10.59863167
70TSSK60.59201907
71IRAK20.58855057
72NTRK10.58778062
73NEK10.56643804
74TYK20.55847272
75TAOK20.54206437
76TTN0.54162093
77CDK120.53129644
78JAK10.52806115
79BRSK20.52529985
80CDK70.52433025
81STK40.50152374
82MAP3K30.49075162
83PAK60.45617141
84EPHB10.45435768
85CLK10.44348920
86MAPKAPK30.43846705
87PDGFRB0.43466031
88MAP2K30.42975429
89OBSCN0.41722589
90CDK30.41207764
91KSR10.40966199
92AKT20.39832446
93GRK50.39256934
94BMPR1B0.39125982
95LRRK20.37943607
96STK380.37091482
97SRPK10.34642055
98MAPK120.34144254
99PRKCI0.33630382
100TAF10.33477111

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053225.57932859
2Alcoholism_Homo sapiens_hsa050343.77590701
3ECM-receptor interaction_Homo sapiens_hsa045122.88083551
4DNA replication_Homo sapiens_hsa030302.54917218
5Ribosome_Homo sapiens_hsa030102.30570678
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.25477048
7Hedgehog signaling pathway_Homo sapiens_hsa043402.19364757
8Focal adhesion_Homo sapiens_hsa045102.14697701
9Other glycan degradation_Homo sapiens_hsa005112.05106332
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.82425494
11Proteoglycans in cancer_Homo sapiens_hsa052051.73452185
12Pertussis_Homo sapiens_hsa051331.70958439
13Basal cell carcinoma_Homo sapiens_hsa052171.66992416
14Melanoma_Homo sapiens_hsa052181.66382175
15Ovarian steroidogenesis_Homo sapiens_hsa049131.58042889
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52959353
17TGF-beta signaling pathway_Homo sapiens_hsa043501.52324100
18Viral carcinogenesis_Homo sapiens_hsa052031.49829181
19Pyrimidine metabolism_Homo sapiens_hsa002401.48181324
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.45644690
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40523979
22Butanoate metabolism_Homo sapiens_hsa006501.38905951
23RNA polymerase_Homo sapiens_hsa030201.37146593
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.36083701
25Phototransduction_Homo sapiens_hsa047441.34748142
26Nucleotide excision repair_Homo sapiens_hsa034201.34204916
27Protein digestion and absorption_Homo sapiens_hsa049741.34173167
28Dilated cardiomyopathy_Homo sapiens_hsa054141.33822340
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.24584678
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22275995
31Amoebiasis_Homo sapiens_hsa051461.20354680
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17915491
33p53 signaling pathway_Homo sapiens_hsa041151.14872688
34Gap junction_Homo sapiens_hsa045401.12676909
35Apoptosis_Homo sapiens_hsa042101.11177286
36Glutathione metabolism_Homo sapiens_hsa004801.09878094
37Olfactory transduction_Homo sapiens_hsa047401.06779137
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.05997517
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03824325
40Platelet activation_Homo sapiens_hsa046111.03381198
41Malaria_Homo sapiens_hsa051441.03361854
42Circadian rhythm_Homo sapiens_hsa047101.03067477
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99995258
44PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94594869
45Folate biosynthesis_Homo sapiens_hsa007900.93905718
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88590258
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84798019
48Pathways in cancer_Homo sapiens_hsa052000.84178493
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78491619
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77535189
51Purine metabolism_Homo sapiens_hsa002300.76837499
52Hippo signaling pathway_Homo sapiens_hsa043900.72056617
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71976737
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71312907
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70358970
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69484157
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69022246
58Complement and coagulation cascades_Homo sapiens_hsa046100.65894624
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.65725022
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65666770
61Prostate cancer_Homo sapiens_hsa052150.64159424
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63654444
63mTOR signaling pathway_Homo sapiens_hsa041500.62845384
64Wnt signaling pathway_Homo sapiens_hsa043100.60085096
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58040224
66African trypanosomiasis_Homo sapiens_hsa051430.57399536
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53791147
68Phagosome_Homo sapiens_hsa041450.53417198
69Melanogenesis_Homo sapiens_hsa049160.52978599
70Small cell lung cancer_Homo sapiens_hsa052220.51336441
71Vibrio cholerae infection_Homo sapiens_hsa051100.50167122
72MicroRNAs in cancer_Homo sapiens_hsa052060.50146481
73Hepatitis B_Homo sapiens_hsa051610.47368994
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47360484
75Galactose metabolism_Homo sapiens_hsa000520.46515599
76Hepatitis C_Homo sapiens_hsa051600.45787801
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45375512
78Glioma_Homo sapiens_hsa052140.45348061
79Legionellosis_Homo sapiens_hsa051340.45091790
80Measles_Homo sapiens_hsa051620.44946699
81Cell cycle_Homo sapiens_hsa041100.44687886
82Nitrogen metabolism_Homo sapiens_hsa009100.44589442
83Tyrosine metabolism_Homo sapiens_hsa003500.44197058
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42279107
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41092026
86Mismatch repair_Homo sapiens_hsa034300.39759893
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39196949
88Rap1 signaling pathway_Homo sapiens_hsa040150.37353936
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36792548
90Prion diseases_Homo sapiens_hsa050200.36383720
91Influenza A_Homo sapiens_hsa051640.35535773
92FoxO signaling pathway_Homo sapiens_hsa040680.35239518
93Bladder cancer_Homo sapiens_hsa052190.34321495
94Base excision repair_Homo sapiens_hsa034100.33062758
95Herpes simplex infection_Homo sapiens_hsa051680.32689093
96HTLV-I infection_Homo sapiens_hsa051660.31916546
97RNA transport_Homo sapiens_hsa030130.30856089
98Oxytocin signaling pathway_Homo sapiens_hsa049210.30042775
99Oocyte meiosis_Homo sapiens_hsa041140.29731477
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27758207

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