HIST2H4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome assembly (GO:0006335)9.17385046
2DNA replication-dependent nucleosome organization (GO:0034723)9.17385046
3mucosal immune response (GO:0002385)8.84507819
4antibacterial humoral response (GO:0019731)8.48705226
5organ or tissue specific immune response (GO:0002251)8.03944775
6antimicrobial humoral response (GO:0019730)7.75358067
7nucleosome assembly (GO:0006334)7.55639440
8chromatin assembly (GO:0031497)7.36136539
9nuclear pore complex assembly (GO:0051292)7.05531204
10nuclear pore organization (GO:0006999)6.47164442
11protein-DNA complex assembly (GO:0065004)6.44628620
12nucleosome organization (GO:0034728)6.37881347
13DNA unwinding involved in DNA replication (GO:0006268)5.89071858
14protein-DNA complex subunit organization (GO:0071824)5.60487029
15DNA strand elongation involved in DNA replication (GO:0006271)5.55638737
16chromatin assembly or disassembly (GO:0006333)5.47464451
17pore complex assembly (GO:0046931)5.44865161
18DNA replication initiation (GO:0006270)5.40780982
19DNA strand elongation (GO:0022616)5.39741892
20regulation of histone H3-K9 methylation (GO:0051570)4.96412131
21telomere maintenance via semi-conservative replication (GO:0032201)4.80024273
22protein localization to chromosome, centromeric region (GO:0071459)4.77666670
23mitotic sister chromatid segregation (GO:0000070)4.64834292
24sister chromatid segregation (GO:0000819)4.45052949
25mitotic chromosome condensation (GO:0007076)4.43845927
26viral mRNA export from host cell nucleus (GO:0046784)4.31322386
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.26826823
28telomere maintenance via recombination (GO:0000722)4.14389728
29negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.13217510
30mitotic nuclear envelope disassembly (GO:0007077)4.03880219
31DNA duplex unwinding (GO:0032508)4.01686502
32mitotic recombination (GO:0006312)3.90137566
33DNA geometric change (GO:0032392)3.87081204
34regulation of translational fidelity (GO:0006450)3.84177857
35CENP-A containing nucleosome assembly (GO:0034080)3.80240701
36chromatin remodeling at centromere (GO:0031055)3.73852549
37nuclear envelope disassembly (GO:0051081)3.70579165
38membrane disassembly (GO:0030397)3.70579165
39non-recombinational repair (GO:0000726)3.69146284
40double-strand break repair via nonhomologous end joining (GO:0006303)3.69146284
41regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.65116065
42protein localization to kinetochore (GO:0034501)3.64759366
43DNA synthesis involved in DNA repair (GO:0000731)3.60883293
44regulation of sister chromatid cohesion (GO:0007063)3.60216416
45DNA replication checkpoint (GO:0000076)3.58353356
46translesion synthesis (GO:0019985)3.50469692
47nucleobase-containing small molecule interconversion (GO:0015949)3.42446441
48nucleotide-excision repair, DNA gap filling (GO:0006297)3.40969396
49positive regulation of chromosome segregation (GO:0051984)3.36648096
50regulation of centrosome cycle (GO:0046605)3.35914341
51defense response to Gram-positive bacterium (GO:0050830)3.31393665
52regulation of chromosome segregation (GO:0051983)3.30812030
53somatic diversification of immune receptors via somatic mutation (GO:0002566)3.28191004
54somatic hypermutation of immunoglobulin genes (GO:0016446)3.28191004
55protein complex localization (GO:0031503)3.24264612
56peptidyl-arginine omega-N-methylation (GO:0035247)3.23432792
57mitochondrial DNA metabolic process (GO:0032042)3.20808395
58mitotic sister chromatid cohesion (GO:0007064)3.18976330
59telomere organization (GO:0032200)3.16484245
60telomere maintenance (GO:0000723)3.15661752
61DNA conformation change (GO:0071103)3.15427641
62cellular protein complex localization (GO:0034629)3.14879031
63rRNA transcription (GO:0009303)3.13863423
64proline biosynthetic process (GO:0006561)3.13469764
65meiotic chromosome segregation (GO:0045132)3.13248800
66regulation of megakaryocyte differentiation (GO:0045652)3.13231884
67negative regulation of chromosome segregation (GO:0051985)3.11726609
68telomere maintenance via telomere lengthening (GO:0010833)3.08963840
69regulation of mammary gland epithelial cell proliferation (GO:0033599)3.04493855
70positive regulation of mitotic sister chromatid separation (GO:1901970)3.02317840
71positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.02317840
72positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.02317840
73regulation of centrosome duplication (GO:0010824)3.01865122
74maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99972514
75positive regulation of cell cycle checkpoint (GO:1901978)2.98068649
76nuclear envelope organization (GO:0006998)2.94873413
77spindle checkpoint (GO:0031577)2.91715161
78mitotic metaphase plate congression (GO:0007080)2.91114501
79DNA replication-independent nucleosome organization (GO:0034724)2.90193578
80DNA replication-independent nucleosome assembly (GO:0006336)2.90193578
81regulation of mitotic sister chromatid segregation (GO:0033047)2.88487820
82regulation of sister chromatid segregation (GO:0033045)2.88487820
83regulation of mitotic sister chromatid separation (GO:0010965)2.88487820
84regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.87588428
85regulation of mitotic metaphase/anaphase transition (GO:0030071)2.87588428
86regulation of spindle checkpoint (GO:0090231)2.87011731
87mitotic spindle assembly checkpoint (GO:0007094)2.86916147
88spindle assembly checkpoint (GO:0071173)2.82537972
89negative regulation of mitotic sister chromatid separation (GO:2000816)2.81942993
90negative regulation of sister chromatid segregation (GO:0033046)2.81942993
91negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81942993
92negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81942993
93negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81942993
94peptidyl-lysine dimethylation (GO:0018027)2.80494292
95V(D)J recombination (GO:0033151)2.78842586
96chromosome condensation (GO:0030261)2.77701347
97replication fork processing (GO:0031297)2.77191687
98histone phosphorylation (GO:0016572)2.76688427
99histone arginine methylation (GO:0034969)2.75459406
100innate immune response in mucosa (GO:0002227)10.7494211

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.88825812
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.31036594
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.17817236
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.69058428
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.20040172
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74542038
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.56401640
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.53767751
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.37826337
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.26901263
11MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.17289409
12SOX2_16153702_ChIP-ChIP_HESCs_Human2.13863512
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.03312049
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse15.9526379
15HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.92061323
16CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.90170533
17POU5F1_16153702_ChIP-ChIP_HESCs_Human1.88227947
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84900309
19NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84455785
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.82524399
21MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79033346
22RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.72054432
23ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65226493
24AR_21909140_ChIP-Seq_LNCAP_Human1.51479464
25ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51071630
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49426857
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49294510
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49221784
29HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45197683
30IRF1_19129219_ChIP-ChIP_H3396_Human1.42857879
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.40114320
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38557581
33SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.31409053
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29020978
35VDR_23849224_ChIP-Seq_CD4+_Human1.25143746
36KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22456288
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21528586
38XRN2_22483619_ChIP-Seq_HELA_Human1.20412931
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18687931
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16812471
41NANOG_16153702_ChIP-ChIP_HESCs_Human1.15889847
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13740013
43DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12642851
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12266066
45VDR_21846776_ChIP-Seq_THP-1_Human1.11971452
46GATA1_22025678_ChIP-Seq_K562_Human1.11890409
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11838606
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11179781
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10249678
50MYC_22102868_ChIP-Seq_BL_Human1.09742240
51ELK1_19687146_ChIP-ChIP_HELA_Human1.07331699
52DCP1A_22483619_ChIP-Seq_HELA_Human1.07260135
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07018645
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05868686
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05691291
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05242122
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.03564530
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03531862
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.03175174
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02399511
61FOXP3_21729870_ChIP-Seq_TREG_Human0.97426507
62SOX2_18692474_ChIP-Seq_MESCs_Mouse0.96112908
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94463489
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93621071
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.92471296
66ETS1_22383799_ChIP-Seq_G1ME_Mouse0.91957668
67NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91303580
68* MYC_18940864_ChIP-ChIP_HL60_Human0.90686000
69EST1_17652178_ChIP-ChIP_JURKAT_Human0.89634363
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89468762
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89388319
72NOTCH1_21737748_ChIP-Seq_TLL_Human0.87812919
73PKCTHETA_26484144_Chip-Seq_BREAST_Human0.87707613
74MYCN_18555785_ChIP-Seq_MESCs_Mouse0.86411834
75CIITA_25753668_ChIP-Seq_RAJI_Human0.85801059
76ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83696240
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82350796
78TTF2_22483619_ChIP-Seq_HELA_Human0.81234188
79TP63_17297297_ChIP-ChIP_HaCaT_Human0.80998411
80KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.80060202
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79385626
82BRD4_27068464_Chip-Seq_AML-cells_Mouse0.78892547
83PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78822893
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.78651812
85KDM5A_27292631_Chip-Seq_BREAST_Human0.78177962
86* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.77936872
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76862220
88VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.75620736
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.75215648
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.74817632
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74371813
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.73556939
93ZNF263_19887448_ChIP-Seq_K562_Human0.73317133
94GABP_17652178_ChIP-ChIP_JURKAT_Human0.72713802
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.69683724
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69588914
97GABP_19822575_ChIP-Seq_HepG2_Human0.69543089
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.68808151
99* MAF_26560356_Chip-Seq_TH1_Human0.68247747
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.67697063

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.37251813
2MP0003111_abnormal_nucleus_morphology4.78267469
3MP0008057_abnormal_DNA_replication4.64810713
4MP0003077_abnormal_cell_cycle4.12080232
5MP0003693_abnormal_embryo_hatching3.78576854
6MP0004957_abnormal_blastocyst_morpholog3.46712775
7MP0010352_gastrointestinal_tract_polyps3.31081348
8MP0010307_abnormal_tumor_latency2.73768690
9MP0002009_preneoplasia2.71869941
10MP0008932_abnormal_embryonic_tissue2.57551740
11MP0008058_abnormal_DNA_repair2.55359722
12MP0008007_abnormal_cellular_replicative2.54293054
13MP0001661_extended_life_span2.51354519
14MP0000537_abnormal_urethra_morphology2.40060449
15MP0003786_premature_aging2.29525111
16MP0010234_abnormal_vibrissa_follicle2.28301352
17MP0002877_abnormal_melanocyte_morpholog2.23946188
18MP0000350_abnormal_cell_proliferation2.12073926
19MP0005623_abnormal_meninges_morphology1.90321613
20MP0004185_abnormal_adipocyte_glucose1.88709159
21MP0009697_abnormal_copulation1.87513997
22MP0002396_abnormal_hematopoietic_system1.86026872
23MP0004808_abnormal_hematopoietic_stem1.85034226
24MP0005645_abnormal_hypothalamus_physiol1.75101917
25MP0000490_abnormal_crypts_of1.72571801
26MP0003763_abnormal_thymus_physiology1.66726970
27MP0005083_abnormal_biliary_tract1.57265600
28MP0001730_embryonic_growth_arrest1.52924836
29MP0002166_altered_tumor_susceptibility1.52232000
30MP0005076_abnormal_cell_differentiation1.51508155
31MP0000313_abnormal_cell_death1.46063906
32MP0002163_abnormal_gland_morphology1.45000527
33MP0002019_abnormal_tumor_incidence1.41151359
34MP0002080_prenatal_lethality1.35647628
35MP0005380_embryogenesis_phenotype1.33705363
36MP0001672_abnormal_embryogenesis/_devel1.33705363
37MP0000358_abnormal_cell_content/1.31453284
38MP0004233_abnormal_muscle_weight1.30729742
39MP0002086_abnormal_extraembryonic_tissu1.29175265
40MP0003705_abnormal_hypodermis_morpholog1.27136296
41MP0000013_abnormal_adipose_tissue1.24081746
42MP0001697_abnormal_embryo_size1.23177200
43MP0003984_embryonic_growth_retardation1.23116645
44MP0002697_abnormal_eye_size1.21549346
45MP0005220_abnormal_exocrine_pancreas1.20728487
46MP0002084_abnormal_developmental_patter1.18191520
47MP0002088_abnormal_embryonic_growth/wei1.18026477
48MP0002006_tumorigenesis1.17773401
49MP0001849_ear_inflammation1.12483824
50MP0006035_abnormal_mitochondrial_morpho1.12443331
51MP0000003_abnormal_adipose_tissue1.10751481
52MP0002085_abnormal_embryonic_tissue1.09799978
53MP0003941_abnormal_skin_development1.08142742
54MP0003718_maternal_effect1.07252431
55MP0003937_abnormal_limbs/digits/tail_de1.06714889
56MP0000703_abnormal_thymus_morphology1.05107757
57MP0001346_abnormal_lacrimal_gland1.03630090
58MP0008438_abnormal_cutaneous_collagen1.01566810
59MP0000685_abnormal_immune_system1.01009253
60MP0002160_abnormal_reproductive_system0.99674101
61MP0002092_abnormal_eye_morphology0.98952264
62MP0002398_abnormal_bone_marrow0.97104052
63MP0010030_abnormal_orbit_morphology0.93422173
64MP0005384_cellular_phenotype0.92249094
65MP0000733_abnormal_muscle_development0.92127275
66MP0002722_abnormal_immune_system0.91179157
67MP0005621_abnormal_cell_physiology0.87865532
68MP0001727_abnormal_embryo_implantation0.83732105
69MP0005451_abnormal_body_composition0.83184597
70MP0002111_abnormal_tail_morphology0.82241757
71MP0005501_abnormal_skin_physiology0.79428318
72MP0000015_abnormal_ear_pigmentation0.74808738
73MP0005187_abnormal_penis_morphology0.73907302
74MP0005171_absent_coat_pigmentation0.73792057
75MP0000689_abnormal_spleen_morphology0.73157609
76MP0003385_abnormal_body_wall0.72528785
77MP0005647_abnormal_sex_gland0.71077443
78MP0002210_abnormal_sex_determination0.68984908
79MP0003315_abnormal_perineum_morphology0.68886445
80MP0001915_intracranial_hemorrhage0.68865996
81MP0004197_abnormal_fetal_growth/weight/0.68631210
82MP0002060_abnormal_skin_morphology0.67454599
83MP0002429_abnormal_blood_cell0.67156653
84MP0001929_abnormal_gametogenesis0.65354812
85MP0001191_abnormal_skin_condition0.63861606
86MP0000747_muscle_weakness0.63837582
87MP0000477_abnormal_intestine_morphology0.63829331
88MP0003699_abnormal_female_reproductive0.63299555
89MP0001145_abnormal_male_reproductive0.61255394
90MP0003453_abnormal_keratinocyte_physiol0.59912566
91MP0000428_abnormal_craniofacial_morphol0.58780366
92MP0002075_abnormal_coat/hair_pigmentati0.57455191
93MP0001835_abnormal_antigen_presentation0.57435254
94MP0001186_pigmentation_phenotype0.55487107
95MP0001243_abnormal_dermal_layer0.55096401
96MP0003221_abnormal_cardiomyocyte_apopto0.51516826
97MP0001119_abnormal_female_reproductive0.51239345
98MP0001286_abnormal_eye_development0.50756539
99MP0009333_abnormal_splenocyte_physiolog0.50603706
100MP0000371_diluted_coat_color0.49412139

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.37892658
2Chromsome breakage (HP:0040012)5.62652649
3IgA deficiency (HP:0002720)4.66638401
4IgM deficiency (HP:0002850)4.29287730
5Squamous cell carcinoma (HP:0002860)3.60025848
6Abnormality of chromosome stability (HP:0003220)3.50923719
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.34391130
8Colitis (HP:0002583)3.27114449
9Abnormality of the preputium (HP:0100587)3.25444857
10Abnormality of the ileum (HP:0001549)3.18352525
11Meckel diverticulum (HP:0002245)3.04475031
12Microvesicular hepatic steatosis (HP:0001414)3.01632783
13Abnormality of the carotid arteries (HP:0005344)2.93718217
14Reticulocytopenia (HP:0001896)2.80823109
15Orthostatic hypotension (HP:0001278)2.77814286
16Medulloblastoma (HP:0002885)2.75529997
17Birth length less than 3rd percentile (HP:0003561)2.74201004
18Aplasia/Hypoplasia of the sacrum (HP:0008517)2.70617009
19Broad distal phalanx of finger (HP:0009836)2.45135515
20Entropion (HP:0000621)2.44716460
21Abnormality of pyrimidine metabolism (HP:0004353)2.43931935
22Ureteral duplication (HP:0000073)2.43004408
23Short thumb (HP:0009778)2.42471338
24Gastrointestinal stroma tumor (HP:0100723)2.40996423
25Small intestinal stenosis (HP:0012848)2.39471484
26Duodenal stenosis (HP:0100867)2.39471484
27Asymmetry of the thorax (HP:0001555)2.39435300
28Clubbing of toes (HP:0100760)2.37765205
29Abnormality of the astrocytes (HP:0100707)2.37096415
30Astrocytoma (HP:0009592)2.37096415
31Nephroblastoma (Wilms tumor) (HP:0002667)2.37090715
32Spastic diplegia (HP:0001264)2.36010316
3311 pairs of ribs (HP:0000878)2.34106616
34Cutaneous melanoma (HP:0012056)2.33304831
35Cellulitis (HP:0100658)2.30947284
36Progressive muscle weakness (HP:0003323)2.30014710
37Hypergonadotropic hypogonadism (HP:0000815)2.28594208
38Hyperacusis (HP:0010780)2.19784026
39Basal cell carcinoma (HP:0002671)2.18940883
40Breast hypoplasia (HP:0003187)2.18369488
41Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.17485010
42Short 4th metacarpal (HP:0010044)2.17485010
43Abnormality of DNA repair (HP:0003254)2.17094603
44Myelodysplasia (HP:0002863)2.16246069
45Progressive external ophthalmoplegia (HP:0000590)2.15072362
46Embryonal renal neoplasm (HP:0011794)2.14922914
47Cafe-au-lait spot (HP:0000957)2.13693263
48Duplicated collecting system (HP:0000081)2.03245169
49Selective tooth agenesis (HP:0001592)2.01986033
50Abnormality of cochlea (HP:0000375)2.01983962
51Hypoplasia of the pons (HP:0012110)2.00955165
52Short nail (HP:0001799)1.97414524
53Arteriovenous malformation (HP:0100026)1.97314866
54Abnormality of the duodenum (HP:0002246)1.96145008
55Ependymoma (HP:0002888)1.95477793
56Glioma (HP:0009733)1.94446112
57Sloping forehead (HP:0000340)1.94236392
58Deep philtrum (HP:0002002)1.90189829
59Dry hair (HP:0011359)1.90142953
60Abnormality of the distal phalanx of the thumb (HP:0009617)1.86599043
61Prominent nose (HP:0000448)1.85048835
62Subacute progressive viral hepatitis (HP:0006572)1.82721934
63Septate vagina (HP:0001153)1.82360331
64Abnormality of the pons (HP:0007361)1.81558434
65Micronodular cirrhosis (HP:0001413)1.81547229
66Sandal gap (HP:0001852)1.79831623
67Ulnar bowing (HP:0003031)1.78947256
68Lymphoma (HP:0002665)1.77342735
69Abnormal foot bone ossification (HP:0010675)1.77204214
70Ragged-red muscle fibers (HP:0003200)1.76988107
71Abnormality of the 4th metacarpal (HP:0010012)1.75730812
72Renovascular hypertension (HP:0100817)1.75407646
73Abnormality of chromosome segregation (HP:0002916)1.72095413
74Insomnia (HP:0100785)1.71025211
75Dysautonomia (HP:0002459)1.69360185
76Viral hepatitis (HP:0006562)1.68592175
77Bone marrow hypocellularity (HP:0005528)1.68568750
78Spinal cord lesions (HP:0100561)1.67895171
79Syringomyelia (HP:0003396)1.67895171
80Duplication of thumb phalanx (HP:0009942)1.67231376
81Missing ribs (HP:0000921)1.67180661
82Abnormality of the renal collecting system (HP:0004742)1.67118874
83Hepatitis (HP:0012115)1.66908134
84Ectopic kidney (HP:0000086)1.66591626
85Abnormality of the distal phalanges of the toes (HP:0010182)1.66545546
86Abnormality of the umbilical cord (HP:0010881)1.66439774
87Down-sloping shoulders (HP:0200021)1.66429618
88Acute lymphatic leukemia (HP:0006721)1.66331650
89Absent radius (HP:0003974)1.65723537
90Sensory axonal neuropathy (HP:0003390)1.64399859
91Absent thumb (HP:0009777)1.63921485
92Uterine leiomyosarcoma (HP:0002891)1.63757888
93Leiomyosarcoma (HP:0100243)1.63757888
94Abnormality of cells of the lymphoid lineage (HP:0012140)1.63266953
95Leukopenia (HP:0001882)1.63245724
96Large eyes (HP:0001090)1.62937701
97Ankyloglossia (HP:0010296)1.61980014
98Recurrent sinusitis (HP:0011108)1.60659692
99Abnormality of the parietal bone (HP:0002696)1.60090227
100Neoplasm of striated muscle (HP:0009728)1.59833032

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK9.02923286
2TLK18.61147225
3VRK14.93407004
4RPS6KA53.45791280
5BUB12.74593723
6DAPK32.57393567
7CDC72.20244960
8AURKA2.11431324
9SMG11.88618259
10STK41.86874369
11SCYL21.82936169
12PBK1.63765464
13CHEK21.62809590
14EEF2K1.48163084
15TRIB31.44643199
16AURKB1.40049057
17NEK11.30307747
18PIM11.26812266
19NME21.21757595
20TTK1.20251799
21SRPK11.16591031
22PKN11.14992707
23TAF11.06612820
24BRSK21.02264366
25MAP3K101.01060571
26ICK1.00701280
27RPS6KB20.95076498
28PIM20.87641357
29ATR0.86383486
30CDK80.83458479
31TTN0.81252211
32MAP3K80.78277925
33IRAK30.77546131
34CCNB10.74103377
35WEE10.73992646
36PLK10.71902065
37BRAF0.70592241
38CDK70.67554063
39MAPK110.65169040
40AKT20.64297645
41TSSK60.63644058
42STK160.61038167
43EIF2AK30.60760260
44NEK90.59891830
45MST1R0.53603674
46CHEK10.51250129
47PRKAA10.49049118
48PLK40.47863156
49CDK120.44246705
50BRSK10.44241781
51CDK60.43712136
52IRAK40.43554190
53KDR0.43180939
54CSNK1G30.42827920
55RAF10.41775398
56CDK40.41031964
57BLK0.39680684
58MAP2K30.39581130
59ATM0.39511405
60PLK30.39441484
61PKN20.36420043
62MELK0.36295871
63CSNK1G10.34766241
64CSNK1A1L0.34555966
65PAK10.30908208
66CDK20.29931879
67NEK20.29914281
68BTK0.26504423
69CAMK1D0.26166863
70MAPKAPK50.24919257
71MAP2K70.24688911
72CAMKK20.24435972
73ILK0.23705756
74CDK10.23511274
75PAK40.22844055
76PRKCI0.21176826
77PRPF4B0.21070487
78IRAK20.20530246
79PDK20.19049873
80MTOR0.18464652
81CAMK40.17090408
82BCKDK0.16488963
83PRKCQ0.15269206
84MAP2K20.13945210
85RPS6KB10.13255388
86ARAF0.12344464
87EIF2AK10.10791289
88BRD40.10362997
89MAP2K40.10018079
90CSNK1G20.09038304
91RPS6KA10.08273397
92EIF2AK20.08067798
93PRKDC0.08007016
94CSNK2A20.07171046
95JAK20.07099565
96CDK90.06765765
97MAP3K40.06683372
98RPS6KC10.06500062
99RPS6KL10.06500062
100CAMK1G0.05636898

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050347.97282423
2* Viral carcinogenesis_Homo sapiens_hsa052033.48428615
3DNA replication_Homo sapiens_hsa030303.08986986
4Mismatch repair_Homo sapiens_hsa034302.08818520
5* Systemic lupus erythematosus_Homo sapiens_hsa0532211.1730090
6Transcriptional misregulation in cancer_Homo sapiens_hsa052021.75617880
7Cell cycle_Homo sapiens_hsa041101.65808876
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64108263
9Non-homologous end-joining_Homo sapiens_hsa034501.62748446
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51809490
11Fanconi anemia pathway_Homo sapiens_hsa034601.40505206
12Base excision repair_Homo sapiens_hsa034101.34951690
13Homologous recombination_Homo sapiens_hsa034401.30426439
14Nucleotide excision repair_Homo sapiens_hsa034201.29222304
15Vitamin B6 metabolism_Homo sapiens_hsa007501.27635329
16Sulfur relay system_Homo sapiens_hsa041221.22172532
17Pyrimidine metabolism_Homo sapiens_hsa002400.96994498
18RNA transport_Homo sapiens_hsa030130.93150727
19Biosynthesis of amino acids_Homo sapiens_hsa012300.93091314
20p53 signaling pathway_Homo sapiens_hsa041150.91056619
21Pentose phosphate pathway_Homo sapiens_hsa000300.84452536
22Selenocompound metabolism_Homo sapiens_hsa004500.78703621
23One carbon pool by folate_Homo sapiens_hsa006700.75200308
24Spliceosome_Homo sapiens_hsa030400.71154032
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67297909
26Primary immunodeficiency_Homo sapiens_hsa053400.65701578
27Ribosome_Homo sapiens_hsa030100.62018519
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53838222
29RNA polymerase_Homo sapiens_hsa030200.53812978
30Central carbon metabolism in cancer_Homo sapiens_hsa052300.53166109
31Non-small cell lung cancer_Homo sapiens_hsa052230.52661062
32Intestinal immune network for IgA production_Homo sapiens_hsa046720.52218321
33Bladder cancer_Homo sapiens_hsa052190.51519379
34Purine metabolism_Homo sapiens_hsa002300.51146336
35N-Glycan biosynthesis_Homo sapiens_hsa005100.50780738
36Small cell lung cancer_Homo sapiens_hsa052220.50159950
37HTLV-I infection_Homo sapiens_hsa051660.49149877
38Carbon metabolism_Homo sapiens_hsa012000.48980913
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47510242
40Chronic myeloid leukemia_Homo sapiens_hsa052200.46985898
41Fructose and mannose metabolism_Homo sapiens_hsa000510.44585993
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44387483
43B cell receptor signaling pathway_Homo sapiens_hsa046620.44069611
44Thyroid cancer_Homo sapiens_hsa052160.42601848
45Epstein-Barr virus infection_Homo sapiens_hsa051690.42295229
46Pancreatic cancer_Homo sapiens_hsa052120.40233875
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40108587
48Galactose metabolism_Homo sapiens_hsa000520.39283923
49MicroRNAs in cancer_Homo sapiens_hsa052060.38315312
50Glioma_Homo sapiens_hsa052140.35259319
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35218355
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.33948168
53Herpes simplex infection_Homo sapiens_hsa051680.33070951
54mRNA surveillance pathway_Homo sapiens_hsa030150.32829879
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32613165
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32032057
57Proteasome_Homo sapiens_hsa030500.30770705
58Basal cell carcinoma_Homo sapiens_hsa052170.29943658
59Apoptosis_Homo sapiens_hsa042100.29706830
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29586221
61Asthma_Homo sapiens_hsa053100.28146903
62Colorectal cancer_Homo sapiens_hsa052100.28103137
63RNA degradation_Homo sapiens_hsa030180.27050009
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25530831
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24728114
66Allograft rejection_Homo sapiens_hsa053300.24521467
67Oocyte meiosis_Homo sapiens_hsa041140.24319761
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.23876033
69Autoimmune thyroid disease_Homo sapiens_hsa053200.23673785
70Hepatitis B_Homo sapiens_hsa051610.23609386
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22879414
72Viral myocarditis_Homo sapiens_hsa054160.21847034
73Inositol phosphate metabolism_Homo sapiens_hsa005620.21246120
74Folate biosynthesis_Homo sapiens_hsa007900.20884401
75Arginine biosynthesis_Homo sapiens_hsa002200.20882514
76Lysine degradation_Homo sapiens_hsa003100.20853322
77Pyruvate metabolism_Homo sapiens_hsa006200.20756409
78Sulfur metabolism_Homo sapiens_hsa009200.20498806
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18858442
80Melanoma_Homo sapiens_hsa052180.17956933
81Prostate cancer_Homo sapiens_hsa052150.17654317
82Basal transcription factors_Homo sapiens_hsa030220.15934441
83Endometrial cancer_Homo sapiens_hsa052130.15251282
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.11671361
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11351773
86Influenza A_Homo sapiens_hsa051640.10884262
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.10633718
88Hippo signaling pathway_Homo sapiens_hsa043900.10537566
89Graft-versus-host disease_Homo sapiens_hsa053320.10428234
90TGF-beta signaling pathway_Homo sapiens_hsa043500.09718819
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.09057889
92Hedgehog signaling pathway_Homo sapiens_hsa043400.08092929
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.07004385
94Acute myeloid leukemia_Homo sapiens_hsa052210.06606676
95Type I diabetes mellitus_Homo sapiens_hsa049400.06012727
96Antigen processing and presentation_Homo sapiens_hsa046120.05904369
97HIF-1 signaling pathway_Homo sapiens_hsa040660.04783199
98Measles_Homo sapiens_hsa051620.04063286
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.03964165
100mTOR signaling pathway_Homo sapiens_hsa041500.03542682

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