HIST2H4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.99037437
2water-soluble vitamin biosynthetic process (GO:0042364)4.21263505
3cornea development in camera-type eye (GO:0061303)4.05527695
4sulfation (GO:0051923)3.83778828
5preassembly of GPI anchor in ER membrane (GO:0016254)3.76436281
6protein complex biogenesis (GO:0070271)3.70657408
7mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.68424163
8mitochondrial respiratory chain complex I assembly (GO:0032981)3.68424163
9NADH dehydrogenase complex assembly (GO:0010257)3.68424163
10DNA replication-dependent nucleosome assembly (GO:0006335)3.59201774
11DNA replication-dependent nucleosome organization (GO:0034723)3.59201774
12mitochondrial respiratory chain complex assembly (GO:0033108)3.55712718
13DNA replication checkpoint (GO:0000076)3.50341195
143-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.44320415
15purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.44320415
16keratinocyte development (GO:0003334)3.39448520
17response to pheromone (GO:0019236)3.38379697
18regulation of cell proliferation involved in kidney development (GO:1901722)3.34936859
19synapsis (GO:0007129)3.25201672
20somatic hypermutation of immunoglobulin genes (GO:0016446)3.23556322
21somatic diversification of immune receptors via somatic mutation (GO:0002566)3.23556322
22respiratory chain complex IV assembly (GO:0008535)3.21790249
23detection of light stimulus involved in sensory perception (GO:0050962)3.20357487
24detection of light stimulus involved in visual perception (GO:0050908)3.20357487
25exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.18835232
26RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.18583677
27replication fork processing (GO:0031297)3.18139987
28indolalkylamine metabolic process (GO:0006586)3.15729287
29somatic diversification of immunoglobulins (GO:0016445)3.15628295
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13717917
31double-strand break repair via homologous recombination (GO:0000724)3.13705085
32protein neddylation (GO:0045116)3.12419762
33recombinational repair (GO:0000725)3.10551608
34protein prenylation (GO:0018342)3.10480838
35prenylation (GO:0097354)3.10480838
36regulation of hippo signaling (GO:0035330)3.09868977
37protein K6-linked ubiquitination (GO:0085020)3.06041731
38somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.04884286
39isotype switching (GO:0045190)3.04884286
40somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.04884286
41replicative senescence (GO:0090399)3.04723474
42somatic recombination of immunoglobulin gene segments (GO:0016447)3.00593610
43negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.97928835
44magnesium ion transport (GO:0015693)2.96121295
45mannosylation (GO:0097502)2.95486568
46pseudouridine synthesis (GO:0001522)2.94666984
47mitochondrial DNA replication (GO:0006264)2.94219604
48regulation of DNA endoreduplication (GO:0032875)2.89312855
49UDP-N-acetylglucosamine metabolic process (GO:0006047)2.87417824
50cytochrome complex assembly (GO:0017004)2.86161474
51tryptophan metabolic process (GO:0006568)2.82080923
52indolalkylamine catabolic process (GO:0046218)2.77912502
53tryptophan catabolic process (GO:0006569)2.77912502
54indole-containing compound catabolic process (GO:0042436)2.77912502
55DNA double-strand break processing (GO:0000729)2.77779100
56DNA methylation involved in gamete generation (GO:0043046)2.75329258
57estrogen metabolic process (GO:0008210)2.72516922
58transcription elongation from RNA polymerase I promoter (GO:0006362)2.71971136
59regulation of glomerulus development (GO:0090192)2.71950430
60rRNA modification (GO:0000154)2.71491154
61innate immune response in mucosa (GO:0002227)2.71150644
62behavioral response to nicotine (GO:0035095)2.70429642
63regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.67148519
64regulation of mitotic spindle checkpoint (GO:1903504)2.67148519
65regulation of nuclear cell cycle DNA replication (GO:0033262)2.66757093
66positive regulation of protein homodimerization activity (GO:0090073)2.66182877
67prostate gland growth (GO:0060736)2.62290620
68mucosal immune response (GO:0002385)2.61878685
69interferon-gamma secretion (GO:0072643)2.58601463
70regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.58029565
71DNA-dependent DNA replication (GO:0006261)2.57265716
72GPI anchor metabolic process (GO:0006505)2.56400156
73epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.56189880
74positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.55798622
75maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.54984096
76piRNA metabolic process (GO:0034587)2.52896786
77rRNA methylation (GO:0031167)2.51342547
78cellular response to ATP (GO:0071318)2.50946217
79meiotic chromosome segregation (GO:0045132)2.50484990
80S-adenosylmethionine metabolic process (GO:0046500)2.50303871
81chromosome organization involved in meiosis (GO:0070192)2.49745026
82tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.49677511
83RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.49677511
84dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.49520872
85pharyngeal system development (GO:0060037)2.49168049
86cell proliferation in forebrain (GO:0021846)2.46994210
87protein-DNA complex assembly (GO:0065004)2.45795481
88somatic diversification of immune receptors (GO:0002200)2.44621569
89tRNA processing (GO:0008033)2.41511985
90maturation of 5.8S rRNA (GO:0000460)2.41049201
91kynurenine metabolic process (GO:0070189)2.38485973
92organ or tissue specific immune response (GO:0002251)2.37465903
93establishment of protein localization to mitochondrial membrane (GO:0090151)2.37145373
94C-terminal protein lipidation (GO:0006501)2.36089405
95dentate gyrus development (GO:0021542)2.35219631
96nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.34420685
97negative regulation of DNA-dependent DNA replication (GO:2000104)2.33926786
98reciprocal meiotic recombination (GO:0007131)2.33476896
99reciprocal DNA recombination (GO:0035825)2.33476896
100nucleosome assembly (GO:0006334)2.33058655

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.47370240
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.13868234
3GABP_17652178_ChIP-ChIP_JURKAT_Human2.79763553
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.70361916
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.65363024
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55988187
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.47553686
8EWS_26573619_Chip-Seq_HEK293_Human2.45793503
9ZNF274_21170338_ChIP-Seq_K562_Hela2.42164111
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36835822
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.28282559
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.23826675
13FUS_26573619_Chip-Seq_HEK293_Human2.13028073
14IGF1R_20145208_ChIP-Seq_DFB_Human2.07554502
15MYC_18940864_ChIP-ChIP_HL60_Human2.04229122
16ELK1_19687146_ChIP-ChIP_HELA_Human2.03495353
17POU5F1_16153702_ChIP-ChIP_HESCs_Human2.03308506
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse10.5810090
19VDR_23849224_ChIP-Seq_CD4+_Human1.97590682
20VDR_22108803_ChIP-Seq_LS180_Human1.92366838
21IRF1_19129219_ChIP-ChIP_H3396_Human1.91114071
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86372152
23E2F7_22180533_ChIP-Seq_HELA_Human1.84646662
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83043885
25* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.78222531
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73598723
27ER_23166858_ChIP-Seq_MCF-7_Human1.72758962
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70327077
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68462070
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62574983
31GBX2_23144817_ChIP-Seq_PC3_Human1.55600246
32SOX2_16153702_ChIP-ChIP_HESCs_Human1.55491629
33FOXP3_21729870_ChIP-Seq_TREG_Human1.53459280
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.53142274
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52370624
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51307434
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.48872465
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41820421
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.41372059
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37981821
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37744268
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36161934
43P300_19829295_ChIP-Seq_ESCs_Human1.28210650
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28132737
45TAF15_26573619_Chip-Seq_HEK293_Human1.27625022
46TDRD3_21172665_ChIP-Seq_MCF-7_Human1.21022289
47TP53_22573176_ChIP-Seq_HFKS_Human1.20076941
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19551484
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.19217253
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19217253
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18290075
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17175272
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15179303
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14319686
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14068083
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10549266
57KDM5A_27292631_Chip-Seq_BREAST_Human1.09474958
58NANOG_16153702_ChIP-ChIP_HESCs_Human1.09249267
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08473121
60NCOR_22424771_ChIP-Seq_293T_Human1.06916505
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05074256
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03550353
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.03032622
64BCAT_22108803_ChIP-Seq_LS180_Human1.00761950
65E2F1_21310950_ChIP-Seq_MCF-7_Human0.99089083
66AR_20517297_ChIP-Seq_VCAP_Human0.99066346
67CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97879995
68TP63_19390658_ChIP-ChIP_HaCaT_Human0.97150185
69RNF2_27304074_Chip-Seq_NSC_Mouse0.92296861
70TTF2_22483619_ChIP-Seq_HELA_Human0.92173239
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91109812
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90320124
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89795014
74SOX2_19829295_ChIP-Seq_ESCs_Human0.89526455
75NANOG_19829295_ChIP-Seq_ESCs_Human0.89526455
76STAT3_23295773_ChIP-Seq_U87_Human0.88801216
77PKCTHETA_26484144_Chip-Seq_BREAST_Human0.85902812
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84610247
79FLI1_27457419_Chip-Seq_LIVER_Mouse0.84230174
80TCF4_23295773_ChIP-Seq_U87_Human0.83052007
81HOXB7_26014856_ChIP-Seq_BT474_Human0.82876139
82LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82619872
83FOXA1_21572438_ChIP-Seq_LNCaP_Human0.81831230
84SMAD4_21799915_ChIP-Seq_A2780_Human0.81528825
85HTT_18923047_ChIP-ChIP_STHdh_Human0.80825214
86AR_25329375_ChIP-Seq_VCAP_Human0.79747197
87ARNT_22903824_ChIP-Seq_MCF-7_Human0.79215734
88FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77589217
89NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77564470
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77215588
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.76360206
92CBP_20019798_ChIP-Seq_JUKART_Human0.75145074
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.75145074
94PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.75114995
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.74897760
96AHR_22903824_ChIP-Seq_MCF-7_Human0.74294958
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73760994
98CDX2_22108803_ChIP-Seq_LS180_Human0.73387675
99ERG_20517297_ChIP-Seq_VCAP_Human0.72832539
100CBX2_27304074_Chip-Seq_ESCs_Mouse0.72058210

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005646_abnormal_pituitary_gland3.66135896
2MP0006292_abnormal_olfactory_placode3.59947262
3MP0008877_abnormal_DNA_methylation3.07649985
4MP0002160_abnormal_reproductive_system2.66329693
5MP0006072_abnormal_retinal_apoptosis2.65360235
6MP0002837_dystrophic_cardiac_calcinosis2.61196001
7MP0008058_abnormal_DNA_repair2.49897834
8MP0003786_premature_aging2.38906847
9MP0003718_maternal_effect2.31645309
10MP0008057_abnormal_DNA_replication2.23750389
11MP0002138_abnormal_hepatobiliary_system2.11467626
12MP0010094_abnormal_chromosome_stability2.10968870
13MP0005389_reproductive_system_phenotype2.05787902
14MP0003195_calcinosis2.01573215
15MP0008995_early_reproductive_senescence2.00860323
16MP0000631_abnormal_neuroendocrine_gland2.00761908
17MP0005379_endocrine/exocrine_gland_phen1.99668775
18MP0008872_abnormal_physiological_respon1.91298724
19MP0003693_abnormal_embryo_hatching1.84416275
20MP0005551_abnormal_eye_electrophysiolog1.81971578
21MP0002102_abnormal_ear_morphology1.74671075
22MP0005253_abnormal_eye_physiology1.70394082
23MP0000372_irregular_coat_pigmentation1.69696580
24MP0002638_abnormal_pupillary_reflex1.65515476
25MP0005084_abnormal_gallbladder_morpholo1.62675139
26MP0002938_white_spotting1.62456182
27MP0009780_abnormal_chondrocyte_physiolo1.57429881
28MP0000383_abnormal_hair_follicle1.57109081
29MP0003011_delayed_dark_adaptation1.56927750
30MP0002163_abnormal_gland_morphology1.55322696
31MP0005083_abnormal_biliary_tract1.53867025
32MP0005220_abnormal_exocrine_pancreas1.49692426
33MP0003646_muscle_fatigue1.44162661
34MP0005367_renal/urinary_system_phenotyp1.40153472
35MP0000516_abnormal_urinary_system1.40153472
36MP0001485_abnormal_pinna_reflex1.39013161
37MP0001968_abnormal_touch/_nociception1.38052963
38MP0008007_abnormal_cellular_replicative1.34801437
39MP0008875_abnormal_xenobiotic_pharmacok1.33992032
40MP0005174_abnormal_tail_pigmentation1.32366232
41MP0001919_abnormal_reproductive_system1.31826217
42MP0008789_abnormal_olfactory_epithelium1.29247021
43MP0001661_extended_life_span1.29037664
44MP0000613_abnormal_salivary_gland1.24988306
45MP0004133_heterotaxia1.24948202
46MP0003787_abnormal_imprinting1.20574160
47MP0005410_abnormal_fertilization1.17712905
48MP0009697_abnormal_copulation1.15208969
49MP0002876_abnormal_thyroid_physiology1.13296228
50MP0010678_abnormal_skin_adnexa1.10705357
51MP0002210_abnormal_sex_determination1.08936778
52MP0001944_abnormal_pancreas_morphology1.08426638
53MP0002736_abnormal_nociception_after1.07610164
54MP0002751_abnormal_autonomic_nervous1.07063522
55MP0003937_abnormal_limbs/digits/tail_de1.06623216
56MP0001929_abnormal_gametogenesis1.06425275
57MP0000427_abnormal_hair_cycle1.05284919
58MP0000653_abnormal_sex_gland1.04655657
59MP0001145_abnormal_male_reproductive0.99887808
60MP0004142_abnormal_muscle_tone0.99704976
61MP0005645_abnormal_hypothalamus_physiol0.97284188
62MP0005332_abnormal_amino_acid0.97237922
63MP0000013_abnormal_adipose_tissue0.97066126
64MP0009046_muscle_twitch0.95147923
65MP0004885_abnormal_endolymph0.93877617
66MP0006035_abnormal_mitochondrial_morpho0.93387674
67MP0008775_abnormal_heart_ventricle0.89958210
68MP0002909_abnormal_adrenal_gland0.89285369
69MP0005075_abnormal_melanosome_morpholog0.88262797
70MP0003698_abnormal_male_reproductive0.87888587
71MP0001324_abnormal_eye_pigmentation0.87654218
72MP0003111_abnormal_nucleus_morphology0.86076037
73MP0001119_abnormal_female_reproductive0.85985364
74MP0002928_abnormal_bile_duct0.85798906
75MP0003119_abnormal_digestive_system0.85708890
76MP0006036_abnormal_mitochondrial_physio0.85395188
77MP0004134_abnormal_chest_morphology0.83912823
78MP0005195_abnormal_posterior_eye0.83511652
79MP0004147_increased_porphyrin_level0.82835482
80MP0001529_abnormal_vocalization0.81988033
81MP0000049_abnormal_middle_ear0.81139796
82MP0004043_abnormal_pH_regulation0.80532610
83MP0004019_abnormal_vitamin_homeostasis0.80394583
84MP0002272_abnormal_nervous_system0.80283398
85MP0009745_abnormal_behavioral_response0.79358861
86MP0002132_abnormal_respiratory_system0.79106120
87MP0001764_abnormal_homeostasis0.78698734
88MP0000015_abnormal_ear_pigmentation0.78655162
89MP0003567_abnormal_fetal_cardiomyocyte0.78610906
90MP0005647_abnormal_sex_gland0.73511186
91MP0001986_abnormal_taste_sensitivity0.72873874
92MP0005391_vision/eye_phenotype0.71323832
93MP0003136_yellow_coat_color0.70960084
94MP0002277_abnormal_respiratory_mucosa0.70020095
95MP0002653_abnormal_ependyma_morphology0.69990235
96MP0002693_abnormal_pancreas_physiology0.68974415
97MP0000470_abnormal_stomach_morphology0.67696874
98MP0003936_abnormal_reproductive_system0.67116078
99MP0002282_abnormal_trachea_morphology0.66604370
100MP0002557_abnormal_social/conspecific_i0.66220129

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.46917975
2Pancreatic cysts (HP:0001737)3.41871815
3Congenital stationary night blindness (HP:0007642)3.33715208
4Pancreatic fibrosis (HP:0100732)3.23513614
5Methylmalonic acidemia (HP:0002912)3.11416662
6Chromsome breakage (HP:0040012)3.10216053
7True hermaphroditism (HP:0010459)3.00348087
8Pendular nystagmus (HP:0012043)2.98599558
9Abnormality of the proximal phalanges of the hand (HP:0009834)2.94574747
10Absent thumb (HP:0009777)2.89605955
11Aplasia/Hypoplasia of the uvula (HP:0010293)2.84928007
12Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.82313456
13Short 1st metacarpal (HP:0010034)2.82313456
14Abolished electroretinogram (ERG) (HP:0000550)2.78692286
15Abnormality of the renal collecting system (HP:0004742)2.78275941
16Ectopic kidney (HP:0000086)2.67065972
17Methylmalonic aciduria (HP:0012120)2.66329608
18Nephronophthisis (HP:0000090)2.65760564
19Meckel diverticulum (HP:0002245)2.62353559
20Abnormality of the nasal septum (HP:0000419)2.59196724
21Abnormality of the ileum (HP:0001549)2.58474061
22Abnormality of DNA repair (HP:0003254)2.55731319
23Congenital, generalized hypertrichosis (HP:0004540)2.54485233
24Abnormality of the preputium (HP:0100587)2.49883168
25Hamartoma of the eye (HP:0010568)2.47336189
26Absent/shortened dynein arms (HP:0200106)2.45615975
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.45615975
28Abnormality of chromosome stability (HP:0003220)2.45441179
29Molar tooth sign on MRI (HP:0002419)2.44945334
30Abnormality of midbrain morphology (HP:0002418)2.44945334
31Thyroiditis (HP:0100646)2.43197896
32Abnormal rod and cone electroretinograms (HP:0008323)2.42052050
33Duplicated collecting system (HP:0000081)2.41547023
34Abnormality of the 1st metacarpal (HP:0010009)2.41508992
35Homocystinuria (HP:0002156)2.40444045
36Abnormality of homocysteine metabolism (HP:0010919)2.40444045
37Short hallux (HP:0010109)2.40348101
38Attenuation of retinal blood vessels (HP:0007843)2.39609443
39Conjunctival hamartoma (HP:0100780)2.39034273
40Decreased central vision (HP:0007663)2.34323837
41Clubbing of toes (HP:0100760)2.31920558
42Furrowed tongue (HP:0000221)2.29812982
43Gaze-evoked nystagmus (HP:0000640)2.29339194
44Aplasia/Hypoplasia of the hallux (HP:0008362)2.28503964
45Abnormality of the renal medulla (HP:0100957)2.24748296
46Abnormality of the renal cortex (HP:0011035)2.22161161
47Meningioma (HP:0002858)2.14095664
48Panhypogammaglobulinemia (HP:0003139)2.13852848
49Mitochondrial inheritance (HP:0001427)2.12933405
50Short thumb (HP:0009778)2.12903525
51Acute necrotizing encephalopathy (HP:0006965)2.12722468
52Decreased electroretinogram (ERG) amplitude (HP:0000654)2.11713718
53Concave nail (HP:0001598)2.09457013
54Abnormality of vitamin B metabolism (HP:0004340)2.08623536
55Chorioretinal atrophy (HP:0000533)2.08501451
56Increased CSF lactate (HP:0002490)2.08360599
573-Methylglutaconic aciduria (HP:0003535)2.04084800
58Short phalanx of the thumb (HP:0009660)2.03407413
59Progressive macrocephaly (HP:0004481)2.03348295
60Hypoplasia of the uterus (HP:0000013)2.02259435
61Aplasia/hypoplasia of the uterus (HP:0008684)2.01824215
62Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01400139
63Genetic anticipation (HP:0003743)1.99168282
64Abnormality of the carotid arteries (HP:0005344)1.98841786
65Bony spicule pigmentary retinopathy (HP:0007737)1.97203929
66Aplasia/Hypoplasia involving the musculature (HP:0001460)1.96729096
67Male pseudohermaphroditism (HP:0000037)1.96454676
68Abnormal mitochondria in muscle tissue (HP:0008316)1.96250582
69Acute encephalopathy (HP:0006846)1.94169771
70Abnormal respiratory epithelium morphology (HP:0012253)1.94005978
71Abnormal respiratory motile cilium morphology (HP:0005938)1.94005978
72Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.93404307
73Hepatocellular necrosis (HP:0001404)1.92874437
74Chronic hepatic failure (HP:0100626)1.90438552
75Oral leukoplakia (HP:0002745)1.89823002
76Cystic liver disease (HP:0006706)1.87272006
77Sclerocornea (HP:0000647)1.86099697
78Abnormality of the vitamin B12 metabolism (HP:0004341)1.85065213
79Small intestinal stenosis (HP:0012848)1.81315959
80Duodenal stenosis (HP:0100867)1.81315959
81Hepatic necrosis (HP:0002605)1.80699896
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80129649
83Abnormality of alanine metabolism (HP:0010916)1.80129649
84Hyperalaninemia (HP:0003348)1.80129649
85Sloping forehead (HP:0000340)1.79395866
86Progressive cerebellar ataxia (HP:0002073)1.78679319
87Small hand (HP:0200055)1.77475027
88Carpal bone hypoplasia (HP:0001498)1.75669262
89Abnormal ciliary motility (HP:0012262)1.73504155
90Hyperglycinemia (HP:0002154)1.73367452
91Abnormality of B cell number (HP:0010975)1.73217114
92Ketosis (HP:0001946)1.71590184
93Keratoconus (HP:0000563)1.70880463
94Increased corneal curvature (HP:0100692)1.70880463
95Aplasia/Hypoplasia of the patella (HP:0006498)1.69991815
96Abnormality of the phalanges of the 5th finger (HP:0004213)1.68249424
97B lymphocytopenia (HP:0010976)1.68230039
98Renal cortical cysts (HP:0000803)1.68024547
99Abnormal respiratory motile cilium physiology (HP:0012261)1.67403695
100Aplasia/Hypoplasia of the fovea (HP:0008060)1.67331250

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK5.26557643
2FRK4.92085529
3TLK14.85446824
4BMPR1B3.96630354
5GRK12.89242082
6STK162.76902958
7MAP4K22.39701659
8ADRBK22.33713744
9VRK12.29739858
10MST42.27922024
11ACVR1B2.12696725
12BRSK22.12304124
13MAPKAPK32.11517419
14WNK31.68824923
15MKNK21.67261033
16EIF2AK31.63337377
17PLK21.49268969
18NUAK11.41962844
19RPS6KA51.27288842
20FLT31.25481413
21CDK81.24440995
22CDC71.23081267
23INSRR1.23045499
24AKT31.17604084
25TAOK31.15491766
26MAPK131.15069064
27PLK31.11726088
28WEE11.08707211
29PINK11.02979686
30TGFBR10.98998709
31WNK40.97938285
32BUB10.97263887
33ERBB30.95756077
34PRKCI0.90700663
35TEC0.88967714
36OXSR10.88416132
37MAP3K40.88248327
38AURKA0.84596658
39IKBKB0.80872889
40EIF2AK10.79200450
41ATR0.77630837
42CHEK20.77629994
43STK390.76273865
44MKNK10.75886573
45TRIM280.74623286
46MAP2K70.70518896
47FER0.70492493
48PRKCE0.68797975
49TNIK0.68468476
50PLK10.67893726
51STK40.67128615
52TAF10.67119560
53RPS6KB20.64369271
54PAK30.64310465
55STK30.64263340
56PTK2B0.61300938
57BCKDK0.60637720
58PIM10.60590081
59ADRBK10.60573776
60PRKAA10.60054709
61DYRK30.58194841
62GRK50.57804692
63FGFR20.56054991
64MAP2K10.55853380
65SRPK10.49688182
66KIT0.48813215
67PDK20.47595665
68VRK20.47087776
69BMPR20.45110628
70ATM0.45092555
71IRAK20.43216743
72TXK0.43216629
73PLK40.42662465
74PHKG10.41971613
75PHKG20.41971613
76PBK0.41465259
77AURKB0.41408402
78RPS6KB10.40408363
79PKN20.40265071
80MUSK0.40040361
81CDK90.39865512
82CSNK1A10.38432293
83DYRK20.38329805
84CSNK1G10.38243671
85IRAK10.36240593
86MAPKAPK50.34637070
87CSNK1G20.34337808
88PIK3CA0.32928268
89MAPK110.32084920
90PRKACA0.31844460
91PRKCG0.31642615
92DAPK30.31632700
93PRKCQ0.31560503
94DAPK10.31229620
95SGK20.30674260
96CCNB10.28167127
97PKN10.27791672
98NLK0.26307351
99PNCK0.25782525
100STK240.24356924

Predicted pathways (KEGG)

RankGene SetZ-score
1* Systemic lupus erythematosus_Homo sapiens_hsa053224.15000408
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.90011212
3* Alcoholism_Homo sapiens_hsa050342.78830404
4Sulfur metabolism_Homo sapiens_hsa009202.77951055
5RNA polymerase_Homo sapiens_hsa030202.57899802
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.49646699
7Selenocompound metabolism_Homo sapiens_hsa004502.46214430
8Fanconi anemia pathway_Homo sapiens_hsa034602.41113614
9Homologous recombination_Homo sapiens_hsa034402.36822123
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.27804033
11One carbon pool by folate_Homo sapiens_hsa006702.10235913
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.09031695
13Nitrogen metabolism_Homo sapiens_hsa009102.01526347
14Basal transcription factors_Homo sapiens_hsa030222.00281587
15Oxidative phosphorylation_Homo sapiens_hsa001901.81709740
16RNA degradation_Homo sapiens_hsa030181.79433753
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.79020543
18Non-homologous end-joining_Homo sapiens_hsa034501.64754473
19Phototransduction_Homo sapiens_hsa047441.62332786
20Proteasome_Homo sapiens_hsa030501.47144726
21Mismatch repair_Homo sapiens_hsa034301.46384964
22Parkinsons disease_Homo sapiens_hsa050121.44930429
23DNA replication_Homo sapiens_hsa030301.43798301
24Chemical carcinogenesis_Homo sapiens_hsa052041.43324055
25Caffeine metabolism_Homo sapiens_hsa002321.41985687
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41725702
27Nucleotide excision repair_Homo sapiens_hsa034201.39776615
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35989867
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29283503
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29230145
31Linoleic acid metabolism_Homo sapiens_hsa005911.27953494
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27686330
33Protein export_Homo sapiens_hsa030601.26068380
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24226823
35Pyrimidine metabolism_Homo sapiens_hsa002401.17326008
36Retinol metabolism_Homo sapiens_hsa008301.15629591
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15362443
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15086677
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.12681365
40Tryptophan metabolism_Homo sapiens_hsa003801.10367184
41Sulfur relay system_Homo sapiens_hsa041221.08204902
42Huntingtons disease_Homo sapiens_hsa050161.06382816
43Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98905302
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95757494
45Purine metabolism_Homo sapiens_hsa002300.95721654
46Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94794577
47RNA transport_Homo sapiens_hsa030130.94725598
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92085407
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91714453
50Ribosome_Homo sapiens_hsa030100.89372489
51Butanoate metabolism_Homo sapiens_hsa006500.88837221
52Peroxisome_Homo sapiens_hsa041460.86999646
53Alzheimers disease_Homo sapiens_hsa050100.86382167
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81289148
55Folate biosynthesis_Homo sapiens_hsa007900.81068988
56Regulation of autophagy_Homo sapiens_hsa041400.79874974
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79178996
58Olfactory transduction_Homo sapiens_hsa047400.78534964
59Dorso-ventral axis formation_Homo sapiens_hsa043200.77412824
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76870050
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.76142119
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76107718
63Nicotine addiction_Homo sapiens_hsa050330.73899896
64Taste transduction_Homo sapiens_hsa047420.73230253
65Ether lipid metabolism_Homo sapiens_hsa005650.72400702
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68072457
67Base excision repair_Homo sapiens_hsa034100.65665869
68Morphine addiction_Homo sapiens_hsa050320.63618474
69Vitamin digestion and absorption_Homo sapiens_hsa049770.62469536
70Metabolic pathways_Homo sapiens_hsa011000.59558055
71Serotonergic synapse_Homo sapiens_hsa047260.58072350
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55340870
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.55268696
74Primary immunodeficiency_Homo sapiens_hsa053400.54744039
75* Viral carcinogenesis_Homo sapiens_hsa052030.53128876
76p53 signaling pathway_Homo sapiens_hsa041150.52409986
77Asthma_Homo sapiens_hsa053100.51618969
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.51527694
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51495579
80Cardiac muscle contraction_Homo sapiens_hsa042600.51366902
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51023950
82Glutathione metabolism_Homo sapiens_hsa004800.49766773
83Insulin secretion_Homo sapiens_hsa049110.48637953
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48008794
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47986202
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.47692000
87TGF-beta signaling pathway_Homo sapiens_hsa043500.47257534
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46905413
89Cell cycle_Homo sapiens_hsa041100.45757435
90Arachidonic acid metabolism_Homo sapiens_hsa005900.43270028
91Collecting duct acid secretion_Homo sapiens_hsa049660.42372134
92Propanoate metabolism_Homo sapiens_hsa006400.41675793
93Spliceosome_Homo sapiens_hsa030400.39521417
94Fat digestion and absorption_Homo sapiens_hsa049750.37095639
95Glycerolipid metabolism_Homo sapiens_hsa005610.36951708
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36653318
97N-Glycan biosynthesis_Homo sapiens_hsa005100.31792287
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30297740
99Melanoma_Homo sapiens_hsa052180.29830856
100Hedgehog signaling pathway_Homo sapiens_hsa043400.29787088

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