HIST3H2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of light stimulus involved in sensory perception (GO:0050962)4.76013267
2detection of light stimulus involved in visual perception (GO:0050908)4.76013267
3ribosomal small subunit assembly (GO:0000028)4.74679487
4neuron cell-cell adhesion (GO:0007158)4.70248671
5translational elongation (GO:0006414)4.62031130
6peptidyl-arginine omega-N-methylation (GO:0035247)4.35645945
7central nervous system myelination (GO:0022010)4.34615982
8axon ensheathment in central nervous system (GO:0032291)4.34615982
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.21496516
10cotranslational protein targeting to membrane (GO:0006613)4.15093426
11DNA replication-dependent nucleosome organization (GO:0034723)4.07057359
12DNA replication-dependent nucleosome assembly (GO:0006335)4.07057359
13maturation of SSU-rRNA (GO:0030490)4.06806243
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.06562992
15protein targeting to ER (GO:0045047)4.05822806
16pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)4.04716980
17CTP metabolic process (GO:0046036)4.03968699
18CTP biosynthetic process (GO:0006241)4.03968699
19histone arginine methylation (GO:0034969)4.03662134
20regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.02945084
21protein localization to synapse (GO:0035418)4.01163289
22viral life cycle (GO:0019058)3.98659741
23guanosine-containing compound biosynthetic process (GO:1901070)3.98627171
24pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.91692020
25rhodopsin mediated signaling pathway (GO:0016056)3.91074349
26establishment of protein localization to endoplasmic reticulum (GO:0072599)3.90379118
27regulation of rhodopsin mediated signaling pathway (GO:0022400)3.86469268
28translational initiation (GO:0006413)3.84676718
29UTP biosynthetic process (GO:0006228)3.84447706
30protein localization to endoplasmic reticulum (GO:0070972)3.83380765
31GTP biosynthetic process (GO:0006183)3.81698536
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.81087567
33retinal cone cell development (GO:0046549)3.78466838
34pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.78372553
35peptidyl-arginine methylation (GO:0018216)3.76763249
36peptidyl-arginine N-methylation (GO:0035246)3.76763249
37nucleosome assembly (GO:0006334)3.72996304
38pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.70188494
39* protein complex disassembly (GO:0043241)3.69725369
40protein complex biogenesis (GO:0070271)3.68087039
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.67311754
42ATP synthesis coupled proton transport (GO:0015986)3.67311754
43mitochondrial respiratory chain complex assembly (GO:0033108)3.67012119
44iron-sulfur cluster assembly (GO:0016226)3.57828608
45metallo-sulfur cluster assembly (GO:0031163)3.57828608
46gamma-aminobutyric acid signaling pathway (GO:0007214)3.56078675
47* macromolecular complex disassembly (GO:0032984)3.55904003
48regulation of dopamine metabolic process (GO:0042053)3.53798464
49regulation of catecholamine metabolic process (GO:0042069)3.53798464
50regulation of mitochondrial translation (GO:0070129)3.52174210
51regulation of translational fidelity (GO:0006450)3.50291221
52UTP metabolic process (GO:0046051)3.50142361
53ribosomal large subunit biogenesis (GO:0042273)3.48234045
54mitochondrial respiratory chain complex I assembly (GO:0032981)3.47567768
55NADH dehydrogenase complex assembly (GO:0010257)3.47567768
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47567768
57pseudouridine synthesis (GO:0001522)3.46801367
58antibacterial humoral response (GO:0019731)3.46386082
59protein-DNA complex assembly (GO:0065004)3.46051052
60retinal rod cell development (GO:0046548)3.45059716
61deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.44222609
62chaperone-mediated protein transport (GO:0072321)3.42635042
63innate immune response in mucosa (GO:0002227)3.38136462
64formation of translation preinitiation complex (GO:0001731)3.35969900
65neuron recognition (GO:0008038)3.35372594
66viral mRNA export from host cell nucleus (GO:0046784)3.34298702
67translation (GO:0006412)3.27599467
68presynaptic membrane assembly (GO:0097105)3.27386922
69protein targeting to mitochondrion (GO:0006626)3.24859937
70histone H2B ubiquitination (GO:0033523)3.24078891
71response to pheromone (GO:0019236)3.23610976
72ribosomal small subunit biogenesis (GO:0042274)3.16583691
73microtubule depolymerization (GO:0007019)3.15053502
74ribonucleoprotein complex biogenesis (GO:0022613)3.12831233
75establishment of protein localization to mitochondrion (GO:0072655)3.12587426
76DNA strand elongation involved in DNA replication (GO:0006271)3.12556090
77cellular component biogenesis (GO:0044085)3.12050705
78negative regulation of microtubule polymerization (GO:0031115)3.11505457
79GMP metabolic process (GO:0046037)3.10935769
80DNA replication initiation (GO:0006270)3.10086317
81DNA strand elongation (GO:0022616)3.07262380
82negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.05927889
83pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.05097707
84nonmotile primary cilium assembly (GO:0035058)3.04727080
85nuclear-transcribed mRNA catabolic process (GO:0000956)3.04519441
86antimicrobial humoral response (GO:0019730)3.04025953
87* nucleosome organization (GO:0034728)3.03221853
88mucosal immune response (GO:0002385)3.03016075
89G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.02045722
90eye photoreceptor cell development (GO:0042462)3.01639479
91presynaptic membrane organization (GO:0097090)2.99590562
92establishment of protein localization to mitochondrial membrane (GO:0090151)2.99095519
93peptidyl-histidine modification (GO:0018202)2.98236305
94photoreceptor cell development (GO:0042461)2.97936271
95dendritic spine morphogenesis (GO:0060997)2.97540519
96establishment of mitochondrion localization (GO:0051654)2.97460861
97DNA replication checkpoint (GO:0000076)2.97376052
98photoreceptor cell maintenance (GO:0045494)2.96503156
99proline biosynthetic process (GO:0006561)2.95620148
100protein localization to mitochondrion (GO:0070585)2.95293087
101dopamine biosynthetic process (GO:0042416)2.95004468
102regulation of mammary gland epithelial cell proliferation (GO:0033599)2.94696911
103protein insertion into membrane (GO:0051205)2.94656382
104axonal fasciculation (GO:0007413)2.92949634
105pyrimidine nucleobase catabolic process (GO:0006208)2.91153198
106mRNA catabolic process (GO:0006402)2.91033074
107L-serine metabolic process (GO:0006563)2.90857564
108vocalization behavior (GO:0071625)2.90448632
109* protein-DNA complex subunit organization (GO:0071824)2.90295281
110membrane hyperpolarization (GO:0060081)2.89897985
111telomere maintenance via semi-conservative replication (GO:0032201)2.89720360
112synaptic vesicle exocytosis (GO:0016079)2.89558238
113mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89190907
114protein targeting to membrane (GO:0006612)2.88658545
115viral transcription (GO:0019083)2.87836194
116tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.86823047
117RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.86823047
118positive regulation of synapse assembly (GO:0051965)2.86102388
119negative regulation of DNA-templated transcription, elongation (GO:0032785)2.82721819
120organ or tissue specific immune response (GO:0002251)2.82360018
121photoreceptor cell differentiation (GO:0046530)2.81822402
122eye photoreceptor cell differentiation (GO:0001754)2.81822402
123termination of RNA polymerase III transcription (GO:0006386)2.81103950
124transcription elongation from RNA polymerase III promoter (GO:0006385)2.81103950
125regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.79561819
126synaptic transmission, dopaminergic (GO:0001963)2.79238176
127chromatin assembly or disassembly (GO:0006333)2.75690698
128cell migration in hindbrain (GO:0021535)2.75461923
129tRNA modification (GO:0006400)2.75184419
130positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.74233178
131rRNA transcription (GO:0009303)2.74144261
132microtubule polymerization or depolymerization (GO:0031109)2.74020585
133long-chain fatty acid biosynthetic process (GO:0042759)2.72671566
134ribonucleoside triphosphate biosynthetic process (GO:0009201)2.72574846
135translational termination (GO:0006415)2.71910973
136glutamate receptor signaling pathway (GO:0007215)2.71339006
137cullin deneddylation (GO:0010388)2.71306556
138pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.70701197
139electron transport chain (GO:0022900)2.69390699
140rRNA processing (GO:0006364)2.69051840
141RNA catabolic process (GO:0006401)2.68945962
142mating behavior (GO:0007617)2.68475174
143transmission of nerve impulse (GO:0019226)2.67223829
144retinal ganglion cell axon guidance (GO:0031290)2.66982545
145GDP-mannose metabolic process (GO:0019673)2.66872998
146replication fork processing (GO:0031297)2.64966440
147protoporphyrinogen IX metabolic process (GO:0046501)2.64892320
148positive regulation of oligodendrocyte differentiation (GO:0048714)2.61763656
149retina layer formation (GO:0010842)2.61010753
150mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.58963864
151regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.57088979
152neuron-neuron synaptic transmission (GO:0007270)2.56577894
153spinal cord motor neuron differentiation (GO:0021522)2.53549676
154synapse assembly (GO:0007416)2.53492898
155regulation of voltage-gated calcium channel activity (GO:1901385)2.53180858
156adult walking behavior (GO:0007628)2.53156826
157myelination (GO:0042552)2.51671325
158ionotropic glutamate receptor signaling pathway (GO:0035235)2.51489183
159positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.51235455
160protoporphyrinogen IX biosynthetic process (GO:0006782)2.48813558
161activated T cell proliferation (GO:0050798)2.47559566
162cellular protein complex disassembly (GO:0043624)2.47535229
163protein neddylation (GO:0045116)2.46991848
164negative regulation of neurotransmitter transport (GO:0051589)2.45369344
165response to histamine (GO:0034776)2.45360494
166ensheathment of neurons (GO:0007272)2.45332191
167axon ensheathment (GO:0008366)2.45332191
168righting reflex (GO:0060013)2.44959670
169dendrite morphogenesis (GO:0048813)2.42730915
170response to methylmercury (GO:0051597)2.42706614
171regulation of short-term neuronal synaptic plasticity (GO:0048172)2.42124043
172postsynaptic membrane organization (GO:0001941)2.41382473
173limb bud formation (GO:0060174)2.40950409
174regulation of histone H3-K9 methylation (GO:0051570)2.39190467
175regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.38074210
176regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.38074210
177neuronal action potential propagation (GO:0019227)2.37217521
178synaptic transmission, glutamatergic (GO:0035249)2.36947936
179chromatin assembly (GO:0031497)2.36874029
180respiratory electron transport chain (GO:0022904)2.36417481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.80256787
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.74369729
3EZH2_22144423_ChIP-Seq_EOC_Human3.65807456
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.38776933
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.32966568
6* RNF2_16625203_ChIP-ChIP_MESCs_Mouse3.03462432
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00797514
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.84254393
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.77561402
10XRN2_22483619_ChIP-Seq_HELA_Human2.73450166
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.70492533
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.67545000
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.65177665
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58145390
15GBX2_23144817_ChIP-Seq_PC3_Human2.51739096
16POU5F1_16153702_ChIP-ChIP_HESCs_Human2.43581552
17* SOX2_16153702_ChIP-ChIP_HESCs_Human2.38421379
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30375870
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.22820905
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.12457314
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00423485
22VDR_22108803_ChIP-Seq_LS180_Human2.00080196
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse12.5417179
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.98940382
25* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96194837
26TTF2_22483619_ChIP-Seq_HELA_Human1.92660942
27CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.91955520
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90929571
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90810881
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.90221352
31GABP_19822575_ChIP-Seq_HepG2_Human1.89887478
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88236753
33DCP1A_22483619_ChIP-Seq_HELA_Human1.87489061
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.87423524
35* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86616081
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80687289
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77706217
38IGF1R_20145208_ChIP-Seq_DFB_Human1.72793963
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71319812
40SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.66003285
41* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65518649
42FOXP3_21729870_ChIP-Seq_TREG_Human1.64563737
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.63895151
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63369581
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.63102297
46FUS_26573619_Chip-Seq_HEK293_Human1.62376810
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.60934359
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59376862
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.58424951
50TAF15_26573619_Chip-Seq_HEK293_Human1.57387017
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.56418355
52REST_21632747_ChIP-Seq_MESCs_Mouse1.55919970
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52562499
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52205767
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.52142025
56* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51710812
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.51686806
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51530478
59SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50392078
60KDM5A_27292631_Chip-Seq_BREAST_Human1.49639898
61CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.48917192
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48902124
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48628329
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47279677
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46432392
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45749705
67* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44974503
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44194267
69CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.40735924
70CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40726165
71CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39807984
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37733960
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37507368
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.36903554
75MYC_18940864_ChIP-ChIP_HL60_Human1.35615878
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34319159
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.32041641
78RNF2_27304074_Chip-Seq_NSC_Mouse1.31206106
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31099184
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29554984
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29402213
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28021910
83* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27165569
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25780783
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25486537
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25040052
87MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23018278
88ZNF274_21170338_ChIP-Seq_K562_Hela1.22940475
89EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22355112
90RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22355112
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.22350714
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20342419
93TET1_21451524_ChIP-Seq_MESCs_Mouse1.18712274
94RNF2_27304074_Chip-Seq_ESCs_Mouse1.18282109
95SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18119315
96NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17153508
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16168756
98* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14902410
99* REST_18959480_ChIP-ChIP_MESCs_Mouse1.14866842
100FOXP1_21924763_ChIP-Seq_HESCs_Human1.14839967
101* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14644549
102CIITA_25753668_ChIP-Seq_RAJI_Human1.13167932
103ZNF263_19887448_ChIP-Seq_K562_Human1.13166446
104KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.12849282
105PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11035145
106SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09691390
107SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09135927
108ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08683595
109CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07349199
110MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06679269
111SOX9_26525672_Chip-Seq_HEART_Mouse1.06658453
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05575971
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05242569
114FOXM1_23109430_ChIP-Seq_U2OS_Human1.05146956
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05113715
116* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05007586
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04526936
118TP63_19390658_ChIP-ChIP_HaCaT_Human1.04522542
119SMAD3_21741376_ChIP-Seq_EPCs_Human1.03144630
120CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03088671
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00163774
122* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99862951
123IRF1_19129219_ChIP-ChIP_H3396_Human0.99789575
124P300_19829295_ChIP-Seq_ESCs_Human0.99183344
125ER_23166858_ChIP-Seq_MCF-7_Human0.98892430
126PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98815122
127TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97359837
128VDR_21846776_ChIP-Seq_THP-1_Human0.97340840
129TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96488606
130EWS_26573619_Chip-Seq_HEK293_Human0.95799410
131* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94638608
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93997029
133RARB_27405468_Chip-Seq_BRAIN_Mouse0.93503706
134P68_20966046_ChIP-Seq_HELA_Human0.92835574
135OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92599761
136NOTCH1_21737748_ChIP-Seq_TLL_Human0.91369998
137* NANOG_16153702_ChIP-ChIP_HESCs_Human0.91317354
138AR_21572438_ChIP-Seq_LNCaP_Human0.89179459
139ELF1_20517297_ChIP-Seq_JURKAT_Human0.88527020
140DROSHA_22980978_ChIP-Seq_HELA_Human0.87983630
141FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87960042
142FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87928169
143RING1B_27294783_Chip-Seq_ESCs_Mouse0.87799867
144OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87681961
145POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85485955
146SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85245657
147CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83964993
148CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83573067
149REST_19997604_ChIP-ChIP_NEURONS_Mouse0.82712955
150GABP_17652178_ChIP-ChIP_JURKAT_Human0.81355462
151DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80028589
152RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79160653
153GATA1_26923725_Chip-Seq_HPCs_Mouse0.79022242
154TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77935326
155SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.77798914
156MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.77262687
157FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.75600763
158* RING1B_27294783_Chip-Seq_NPCs_Mouse0.74607889
159EST1_17652178_ChIP-ChIP_JURKAT_Human0.74169931
160ELK1_19687146_ChIP-ChIP_HELA_Human0.74085555
161P53_22127205_ChIP-Seq_FIBROBLAST_Human0.73159216
162VDR_23849224_ChIP-Seq_CD4+_Human0.72902728
163GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.72080358
164TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70750942
165POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.70750942
166POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.68544310
167TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.67174214

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.60013595
2MP0005551_abnormal_eye_electrophysiolog3.57153858
3MP0001529_abnormal_vocalization3.34429724
4MP0006072_abnormal_retinal_apoptosis3.25291260
5MP0005423_abnormal_somatic_nervous2.75542001
6MP0003693_abnormal_embryo_hatching2.73134857
7MP0005253_abnormal_eye_physiology2.56296439
8MP0004859_abnormal_synaptic_plasticity2.34787874
9MP0000778_abnormal_nervous_system2.31576052
10MP0001984_abnormal_olfaction2.29853710
11MP0001486_abnormal_startle_reflex2.28186442
12MP0003111_abnormal_nucleus_morphology2.28042230
13MP0010094_abnormal_chromosome_stability2.26481981
14MP0002822_catalepsy2.25019749
15MP0001905_abnormal_dopamine_level2.20830007
16MP0002249_abnormal_larynx_morphology2.18271565
17MP0003635_abnormal_synaptic_transmissio2.13634268
18MP0006292_abnormal_olfactory_placode2.13463368
19MP0004270_analgesia2.11664610
20MP0006276_abnormal_autonomic_nervous2.03015595
21MP0002272_abnormal_nervous_system2.02993177
22MP0002734_abnormal_mechanical_nocicepti2.01584894
23MP0002638_abnormal_pupillary_reflex2.01063040
24MP0003077_abnormal_cell_cycle1.98607094
25MP0004957_abnormal_blastocyst_morpholog1.93124623
26MP0002184_abnormal_innervation1.85946520
27MP0001968_abnormal_touch/_nociception1.85628157
28MP0004742_abnormal_vestibular_system1.84584804
29MP0002064_seizures1.84308753
30MP0000537_abnormal_urethra_morphology1.83844654
31MP0002063_abnormal_learning/memory/cond1.80213207
32MP0003136_yellow_coat_color1.80090158
33MP0005195_abnormal_posterior_eye1.78933532
34MP0009745_abnormal_behavioral_response1.78520675
35MP0001293_anophthalmia1.77388179
36MP0002653_abnormal_ependyma_morphology1.73567112
37MP0006035_abnormal_mitochondrial_morpho1.73171537
38MP0002102_abnormal_ear_morphology1.72933914
39MP0004142_abnormal_muscle_tone1.72727763
40MP0002160_abnormal_reproductive_system1.70361313
41MP0002572_abnormal_emotion/affect_behav1.69616709
42MP0001188_hyperpigmentation1.68937748
43MP0002752_abnormal_somatic_nervous1.66510239
44MP0002882_abnormal_neuron_morphology1.64193085
45MP0008789_abnormal_olfactory_epithelium1.62700107
46MP0002736_abnormal_nociception_after1.61765673
47MP0009046_muscle_twitch1.61481924
48MP0003315_abnormal_perineum_morphology1.60365266
49MP0000631_abnormal_neuroendocrine_gland1.56395524
50MP0002067_abnormal_sensory_capabilities1.56004414
51MP0003950_abnormal_plasma_membrane1.55860427
52MP0005409_darkened_coat_color1.55163004
53MP0000678_abnormal_parathyroid_gland1.54815056
54MP0003011_delayed_dark_adaptation1.54796639
55MP0003786_premature_aging1.51418644
56MP0003123_paternal_imprinting1.47931171
57MP0002090_abnormal_vision1.47607809
58MP0002229_neurodegeneration1.45813494
59MP0001502_abnormal_circadian_rhythm1.45710178
60MP0001440_abnormal_grooming_behavior1.40719717
61MP0000955_abnormal_spinal_cord1.40011569
62MP0003942_abnormal_urinary_system1.39422006
63MP0005499_abnormal_olfactory_system1.38955011
64MP0005394_taste/olfaction_phenotype1.38955011
65MP0002557_abnormal_social/conspecific_i1.35833747
66MP0002735_abnormal_chemical_nociception1.35219300
67MP0005171_absent_coat_pigmentation1.34308999
68MP0005391_vision/eye_phenotype1.32266075
69MP0010386_abnormal_urinary_bladder1.32221322
70MP0002163_abnormal_gland_morphology1.30245498
71MP0001485_abnormal_pinna_reflex1.29615188
72MP0005386_behavior/neurological_phenoty1.29191778
73MP0004924_abnormal_behavior1.29191778
74MP0000920_abnormal_myelination1.27004502
75MP0009379_abnormal_foot_pigmentation1.25765010
76MP0004147_increased_porphyrin_level1.25090950
77MP0008877_abnormal_DNA_methylation1.22419415
78MP0002152_abnormal_brain_morphology1.22285318
79MP0001970_abnormal_pain_threshold1.22153023
80MP0002697_abnormal_eye_size1.20993358
81MP0000026_abnormal_inner_ear1.20873362
82MP0008007_abnormal_cellular_replicative1.19912171
83MP0001963_abnormal_hearing_physiology1.18989415
84MP0003861_abnormal_nervous_system1.16964901
85MP0005083_abnormal_biliary_tract1.16727535
86MP0002751_abnormal_autonomic_nervous1.12957251
87MP0004811_abnormal_neuron_physiology1.12789595
88MP0003634_abnormal_glial_cell1.12483035
89MP0003283_abnormal_digestive_organ1.10104992
90MP0001324_abnormal_eye_pigmentation1.09432954
91MP0003938_abnormal_ear_development1.09023525
92MP0002210_abnormal_sex_determination1.08671985
93MP0009053_abnormal_anal_canal1.08344546
94MP0002066_abnormal_motor_capabilities/c1.06372965
95MP0003718_maternal_effect1.05321344
96MP0003787_abnormal_imprinting1.04106394
97MP0004885_abnormal_endolymph1.02723652
98MP0002733_abnormal_thermal_nociception1.02552029
99MP0000462_abnormal_digestive_system1.01788873
100MP0004185_abnormal_adipocyte_glucose1.01670851
101MP0005187_abnormal_penis_morphology1.01164914
102MP0001986_abnormal_taste_sensitivity1.00535711
103MP0002282_abnormal_trachea_morphology0.99802221
104MP0005410_abnormal_fertilization0.99616610
105MP0003121_genomic_imprinting0.99605519
106MP0002233_abnormal_nose_morphology0.99424613
107MP0001286_abnormal_eye_development0.97889288
108MP0000358_abnormal_cell_content/0.96467524
109MP0000566_synostosis0.95176910
110MP0001919_abnormal_reproductive_system0.94522952
111MP0000350_abnormal_cell_proliferation0.94209060
112MP0004134_abnormal_chest_morphology0.94129666
113MP0003122_maternal_imprinting0.93841380
114MP0002092_abnormal_eye_morphology0.93820178
115MP0004133_heterotaxia0.93796690
116MP0001145_abnormal_male_reproductive0.92153933
117MP0005501_abnormal_skin_physiology0.91035370
118MP0003119_abnormal_digestive_system0.90609308
119MP0002085_abnormal_embryonic_tissue0.90562711
120MP0005389_reproductive_system_phenotype0.90538426
121MP0010030_abnormal_orbit_morphology0.90015063
122MP0001929_abnormal_gametogenesis0.88498808
123MP0002111_abnormal_tail_morphology0.88091939
124MP0003186_abnormal_redox_activity0.87426445
125MP0000313_abnormal_cell_death0.87072964
126MP0001764_abnormal_homeostasis0.86662181
127MP0001727_abnormal_embryo_implantation0.86066941
128MP0008932_abnormal_embryonic_tissue0.86023807
129MP0002177_abnormal_outer_ear0.85110811
130MP0003937_abnormal_limbs/digits/tail_de0.84557367
131MP0003137_abnormal_impulse_conducting0.84493212
132MP0001270_distended_abdomen0.83637309
133MP0005645_abnormal_hypothalamus_physiol0.83029216
134MP0003698_abnormal_male_reproductive0.82932677
135MP0000049_abnormal_middle_ear0.82389172
136MP0006036_abnormal_mitochondrial_physio0.81910305
137MP0000653_abnormal_sex_gland0.80740445
138MP0001346_abnormal_lacrimal_gland0.79160256
139MP0008058_abnormal_DNA_repair0.79147486
140MP0000372_irregular_coat_pigmentation0.79126950
141MP0002084_abnormal_developmental_patter0.77317589
142MP0003755_abnormal_palate_morphology0.75983507
143MP0002234_abnormal_pharynx_morphology0.74738602
144MP0002938_white_spotting0.74254533
145MP0001299_abnormal_eye_distance/0.73112553
146MP0002277_abnormal_respiratory_mucosa0.73086835
147MP0008995_early_reproductive_senescence0.72117021
148MP0003656_abnormal_erythrocyte_physiolo0.71645270
149MP0005623_abnormal_meninges_morphology0.71211904
150MP0001943_abnormal_respiration0.66628205

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.96841233
2Aplasia/Hypoplasia of the sacrum (HP:0008517)3.96129061
3Abnormal rod and cone electroretinograms (HP:0008323)3.40194356
4Abnormality of macular pigmentation (HP:0008002)3.40011429
5Bony spicule pigmentary retinopathy (HP:0007737)3.34711104
6Decreased central vision (HP:0007663)3.28050294
7Increased intramyocellular lipid droplets (HP:0012240)3.24805104
8Central scotoma (HP:0000603)3.23730802
9Decreased activity of mitochondrial respiratory chain (HP:0008972)3.10100369
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.10100369
11Degeneration of the lateral corticospinal tracts (HP:0002314)3.08462846
12Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.08462846
13Acute necrotizing encephalopathy (HP:0006965)3.01393159
14Gait imbalance (HP:0002141)2.95074811
15Broad distal phalanx of finger (HP:0009836)2.94126897
16Increased muscle lipid content (HP:0009058)2.89617232
17Medial flaring of the eyebrow (HP:0010747)2.80647248
18Attenuation of retinal blood vessels (HP:0007843)2.79750604
19Severe visual impairment (HP:0001141)2.79435247
20Dyschromatopsia (HP:0007641)2.79272124
21Hepatic necrosis (HP:0002605)2.75013225
22Optic disc pallor (HP:0000543)2.72628542
23Microvesicular hepatic steatosis (HP:0001414)2.69248122
24Absent rod-and cone-mediated responses on ERG (HP:0007688)2.67712582
25Abnormal mitochondria in muscle tissue (HP:0008316)2.66314487
26Increased serum lactate (HP:0002151)2.65517372
27Congenital primary aphakia (HP:0007707)2.62253490
28Sensory axonal neuropathy (HP:0003390)2.62197794
29Pallor (HP:0000980)2.60812471
30Mitochondrial inheritance (HP:0001427)2.59249496
31Increased hepatocellular lipid droplets (HP:0006565)2.59208055
32Epileptic encephalopathy (HP:0200134)2.56871390
33Progressive macrocephaly (HP:0004481)2.53252639
34Increased corneal curvature (HP:0100692)2.52887490
35Keratoconus (HP:0000563)2.52887490
36Lactic acidosis (HP:0003128)2.49033696
37Septo-optic dysplasia (HP:0100842)2.48782349
38Abnormality of reticulocytes (HP:0004312)2.48170065
39Pendular nystagmus (HP:0012043)2.45236905
40Myokymia (HP:0002411)2.44552039
41Abnormal number of incisors (HP:0011064)2.42512433
42Microretrognathia (HP:0000308)2.40347579
43Limb dystonia (HP:0002451)2.36494368
44Chromosomal breakage induced by crosslinking agents (HP:0003221)2.36037220
45Nephrogenic diabetes insipidus (HP:0009806)2.35171790
46Vaginal atresia (HP:0000148)2.35063031
47Cerebral edema (HP:0002181)2.35059771
48Abnormality of the corticospinal tract (HP:0002492)2.33094232
49Type II lissencephaly (HP:0007260)2.30945851
50Absent/shortened dynein arms (HP:0200106)2.30466277
51Dynein arm defect of respiratory motile cilia (HP:0012255)2.30466277
52Hypoplasia of the pons (HP:0012110)2.29072532
53Genital tract atresia (HP:0001827)2.28612714
54Abnormality of the parathyroid morphology (HP:0011766)2.25206080
55Scotoma (HP:0000575)2.22660308
56Abnormality of cochlea (HP:0000375)2.21697983
57Birth length less than 3rd percentile (HP:0003561)2.21553380
58Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.20437622
59Absent septum pellucidum (HP:0001331)2.20424172
60Focal motor seizures (HP:0011153)2.16274326
61Optic nerve coloboma (HP:0000588)2.13901141
62Abnormality of the labia minora (HP:0012880)2.13759992
63Delusions (HP:0000746)2.13660686
64Exercise intolerance (HP:0003546)2.13079131
65Abnormality of the septum pellucidum (HP:0007375)2.13026700
66Absent thumb (HP:0009777)2.12723548
67Abnormality of the heme biosynthetic pathway (HP:0010472)2.10673906
68Cerebral hypomyelination (HP:0006808)2.09908325
69Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.09828997
70Spastic gait (HP:0002064)2.09639569
71Renal Fanconi syndrome (HP:0001994)2.08942138
72Abnormality of cells of the erythroid lineage (HP:0012130)2.08692267
73Parakeratosis (HP:0001036)2.08481070
74Abnormality of the pons (HP:0007361)2.08351663
75Aplasia/Hypoplasia of the lens (HP:0008063)2.06476256
76Morphological abnormality of the inner ear (HP:0011390)2.03341371
77Neurofibrillary tangles (HP:0002185)2.03286204
78Poor suck (HP:0002033)2.01824188
79Septate vagina (HP:0001153)2.01379762
80Retinitis pigmentosa (HP:0000510)2.00466281
81Atonic seizures (HP:0010819)1.99170929
82Retinal dysplasia (HP:0007973)1.98152583
83Growth hormone deficiency (HP:0000824)1.97806862
84Increased serum pyruvate (HP:0003542)1.97112467
85Abnormality of glycolysis (HP:0004366)1.97112467
86Focal seizures (HP:0007359)1.96677065
87Type II diabetes mellitus (HP:0005978)1.96453746
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95859946
89Abnormal ciliary motility (HP:0012262)1.95833327
90Esotropia (HP:0000565)1.95816905
91Supranuclear gaze palsy (HP:0000605)1.94172318
92Duplication of thumb phalanx (HP:0009942)1.94154710
93Abnormality of DNA repair (HP:0003254)1.93976741
94Akinesia (HP:0002304)1.93792695
95Truncus arteriosus (HP:0001660)1.93540883
96Ragged-red muscle fibers (HP:0003200)1.93047630
97Specific learning disability (HP:0001328)1.92973044
98Chromsome breakage (HP:0040012)1.92455895
99Leukodystrophy (HP:0002415)1.92143075
100Aplasia/Hypoplasia of the patella (HP:0006498)1.91724883
101Acute encephalopathy (HP:0006846)1.91565073
102Lipid accumulation in hepatocytes (HP:0006561)1.90906359
103Reticulocytopenia (HP:0001896)1.88962933
104Occipital encephalocele (HP:0002085)1.88961732
105Sclerocornea (HP:0000647)1.88735452
106Concave nail (HP:0001598)1.87843422
107Anteriorly placed anus (HP:0001545)1.86414079
108Triphalangeal thumb (HP:0001199)1.85895481
109Increased CSF lactate (HP:0002490)1.85800753
110Abnormal hair whorl (HP:0010721)1.85656234
111Febrile seizures (HP:0002373)1.85416853
112Patellar aplasia (HP:0006443)1.85224635
113Breast hypoplasia (HP:0003187)1.84223915
114Absence seizures (HP:0002121)1.83303502
115Respiratory failure (HP:0002878)1.82925769
116Photophobia (HP:0000613)1.82725770
117Truncal ataxia (HP:0002078)1.81944759
118Abnormal respiratory motile cilium morphology (HP:0005938)1.81642330
119Abnormal respiratory epithelium morphology (HP:0012253)1.81642330
120Hypoplastic pelvis (HP:0008839)1.81576728
121Bile duct proliferation (HP:0001408)1.81388537
122Abnormal biliary tract physiology (HP:0012439)1.81388537
123Hypoplasia of the brainstem (HP:0002365)1.81164869
124Aplasia/Hypoplasia of the brainstem (HP:0007362)1.81164869
125Abnormality of the aortic arch (HP:0012303)1.81135820
126Dialeptic seizures (HP:0011146)1.80826404
127Cerebral inclusion bodies (HP:0100314)1.80797224
128Horseshoe kidney (HP:0000085)1.80166685
129Visual hallucinations (HP:0002367)1.79734064
1303-Methylglutaconic aciduria (HP:0003535)1.79292629
131Congenital malformation of the right heart (HP:0011723)1.77972520
132Double outlet right ventricle (HP:0001719)1.77972520
133Macrocytic anemia (HP:0001972)1.77742543
134Hepatocellular necrosis (HP:0001404)1.77168516
135Abnormal respiratory motile cilium physiology (HP:0012261)1.76257876
136Polyphagia (HP:0002591)1.75639093
137Amblyopia (HP:0000646)1.75408493
138Reticulocytosis (HP:0001923)1.75216388
139Cone-rod dystrophy (HP:0000548)1.74671021
140Anophthalmia (HP:0000528)1.72910993
141Cerebellar dysplasia (HP:0007033)1.72674857
142Abnormal auditory evoked potentials (HP:0006958)1.72206353
143Poor eye contact (HP:0000817)1.71727685
144Hyperthyroidism (HP:0000836)1.71657572
145Emotional lability (HP:0000712)1.71208264
146Colon cancer (HP:0003003)1.70524563
147Choroideremia (HP:0001139)1.70168418
148Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.69407267
149Severe muscular hypotonia (HP:0006829)1.69381584
150Spastic diplegia (HP:0001264)1.69277267
151Abnormal number of erythroid precursors (HP:0012131)1.69115827
152Excessive salivation (HP:0003781)1.69008290
153Drooling (HP:0002307)1.69008290
154Abnormal gallbladder physiology (HP:0012438)1.67234809
155Cholecystitis (HP:0001082)1.67234809
156Progressive microcephaly (HP:0000253)1.67213472
157Maternal diabetes (HP:0009800)1.67030299
158Abnormality of the renal collecting system (HP:0004742)1.66925213
159Self-mutilation (HP:0000742)1.65795322
160Respiratory difficulties (HP:0002880)1.65365727
161Absent radius (HP:0003974)1.64016688
162Renal dysplasia (HP:0000110)1.63682195
163Lissencephaly (HP:0001339)1.63226371
164Facial cleft (HP:0002006)1.63121998
165Aplastic anemia (HP:0001915)1.62338750
166Absent forearm bone (HP:0003953)1.62301911
167Aplasia involving forearm bones (HP:0009822)1.62301911
168Duplicated collecting system (HP:0000081)1.61877470
169Aplasia/Hypoplasia of the uvula (HP:0010293)1.61673841
170Unsteady gait (HP:0002317)1.61294573
171Preaxial hand polydactyly (HP:0001177)1.60756357
172Down-sloping shoulders (HP:0200021)1.60522524
173Squamous cell carcinoma (HP:0002860)1.59381903
174Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.58618915
175Abnormality of alanine metabolism (HP:0010916)1.58618915
176Hyperalaninemia (HP:0003348)1.58618915
177Single umbilical artery (HP:0001195)1.58202203
178Abnormality of the fetal cardiovascular system (HP:0010948)1.58202203

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK17.78798342
2ZAK3.43705475
3VRK13.24862682
4MARK13.06396472
5NME22.98242636
6PKN12.45019568
7TRIB32.34732514
8PNCK2.18604509
9STK392.17663871
10VRK22.08655319
11TNIK2.08203617
12PBK2.06078542
13* RPS6KA51.99427787
14DYRK21.95479421
15PIM21.94656076
16BCKDK1.88653489
17UHMK11.70650995
18DYRK31.65262206
19BCR1.60532617
20STK161.59440899
21MAPK131.58397926
22NTRK21.56136916
23INSRR1.52384907
24OXSR11.50904434
25SMG11.49332827
26IRAK31.43758767
27CASK1.39000966
28STK41.38832464
29DYRK1A1.31158572
30SRPK11.29826894
31NME11.22717185
32LIMK11.20183519
33CDK81.19795513
34PRPF4B1.16887465
35EEF2K1.16296647
36CDK91.11153054
37TAF11.10580555
38MAP2K71.07895025
39FGR1.06281718
40PAK61.06227412
41MAP3K41.04281620
42DYRK1B1.03718637
43BMPR1B1.01870074
44CSNK1G31.00328690
45CDK190.99896845
46AURKA0.98994409
47ICK0.98439840
48NTRK30.98190636
49MAP3K110.97782331
50EPHA40.96962605
51BUB10.96342419
52PIM10.93246605
53KDR0.91753663
54MINK10.91635653
55CDK180.91108287
56CDK150.90220555
57CDK140.89926899
58ILK0.89764709
59ATR0.89307031
60MAPK150.89226805
61KSR10.88918436
62PLK10.88666592
63MAPKAPK50.86022383
64CCNB10.85888695
65BRSK10.85607628
66TAOK30.85321201
67CHEK20.85208250
68WNK30.84768370
69CDC70.83099075
70MAP4K20.82470136
71DAPK30.81238969
72CDK11A0.80369492
73CDK50.80197194
74PRKD30.77156832
75BRD40.77102899
76CAMK2B0.76601442
77WNK40.76490873
78TTK0.76324016
79NUAK10.76243985
80NEK10.75400304
81CDK30.75285564
82CDK70.75194139
83TSSK60.71622481
84PHKG10.68041511
85PHKG20.68041511
86CSNK1G20.67877157
87CLK10.66319938
88ABL20.65594716
89CSNK1A1L0.64072602
90TAOK20.61762121
91CSNK1G10.60613306
92GRK50.60422564
93FES0.59971382
94ARAF0.59020338
95SIK20.58513305
96PRKCI0.57307950
97MAP3K90.56237302
98PAK30.54990530
99ROCK20.54502580
100MAP2K40.53881302
101CAMK2A0.53400920
102AURKB0.53138161
103SGK4940.52704750
104SGK2230.52704750
105DAPK10.52127492
106IRAK10.51380469
107EPHA20.51274557
108CAMK1G0.50948283
109TYRO30.50203443
110MST40.49856712
111WEE10.49284036
112FGFR20.48904550
113SCYL20.46733390
114IRAK20.46506553
115CSNK1D0.45495643
116CHEK10.45435966
117ADRBK10.45063430
118CAMK2D0.44772802
119TESK20.43918183
120CAMKK20.42375619
121CSNK2A10.41783131
122CSNK2A20.41687758
123BRAF0.41512378
124MAPK90.40123211
125CAMK1D0.38622538
126AKT20.38340768
127MARK20.38252437
128LRRK20.37433616
129CAMK40.36987341
130CAMKK10.36611092
131MAP2K20.36464062
132YES10.36024810
133ROCK10.35800739
134ATM0.35328266
135MET0.35293163
136CDK10.35285739
137CDK20.35274323
138RPS6KL10.35147148
139RPS6KC10.35147148
140PKN20.34825587
141RPS6KB20.34647647
142PLK40.34561314
143EPHB20.34477786
144PRKAA10.34299396
145BRSK20.33926724
146PAK10.33904901
147GRK10.33727635
148PLK30.33151996
149RPS6KA40.32924495
150ERBB30.32738475
151MAP3K120.32093638
152RPS6KA60.31725769
153NEK20.31247212

Predicted pathways (KEGG)

RankGene SetZ-score
1* Systemic lupus erythematosus_Homo sapiens_hsa053226.75962304
2* Alcoholism_Homo sapiens_hsa050344.77332910
3Phototransduction_Homo sapiens_hsa047443.89088997
4Sulfur relay system_Homo sapiens_hsa041223.85165856
5Oxidative phosphorylation_Homo sapiens_hsa001902.90118555
6Nicotine addiction_Homo sapiens_hsa050332.81667045
7Parkinsons disease_Homo sapiens_hsa050122.37688537
8Ribosome_Homo sapiens_hsa030102.27862950
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12449871
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98988363
11Alzheimers disease_Homo sapiens_hsa050101.97824139
12Huntingtons disease_Homo sapiens_hsa050161.85051549
13Synaptic vesicle cycle_Homo sapiens_hsa047211.84677337
14GABAergic synapse_Homo sapiens_hsa047271.84390205
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.78374243
16Collecting duct acid secretion_Homo sapiens_hsa049661.78250193
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76023693
18Cardiac muscle contraction_Homo sapiens_hsa042601.69924342
19Morphine addiction_Homo sapiens_hsa050321.60343310
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59827403
21Viral carcinogenesis_Homo sapiens_hsa052031.49360710
22RNA polymerase_Homo sapiens_hsa030201.48116336
23Biosynthesis of amino acids_Homo sapiens_hsa012301.46559453
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46091042
25Serotonergic synapse_Homo sapiens_hsa047261.40657978
26Axon guidance_Homo sapiens_hsa043601.36647075
27Glutamatergic synapse_Homo sapiens_hsa047241.33363270
28Spliceosome_Homo sapiens_hsa030401.28638118
29Circadian entrainment_Homo sapiens_hsa047131.27739312
30Dopaminergic synapse_Homo sapiens_hsa047281.26457807
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.21747835
32Taste transduction_Homo sapiens_hsa047421.20678159
33One carbon pool by folate_Homo sapiens_hsa006701.19881625
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19321632
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17544399
36Selenocompound metabolism_Homo sapiens_hsa004501.17107662
37Proteasome_Homo sapiens_hsa030501.12111213
38Vitamin B6 metabolism_Homo sapiens_hsa007501.11494493
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10605337
40Cholinergic synapse_Homo sapiens_hsa047251.08669300
41Protein export_Homo sapiens_hsa030601.04454985
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03654836
43Vibrio cholerae infection_Homo sapiens_hsa051101.02371741
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00670951
45Basal cell carcinoma_Homo sapiens_hsa052170.98619648
46Fanconi anemia pathway_Homo sapiens_hsa034600.97990136
47Mismatch repair_Homo sapiens_hsa034300.97021259
48Olfactory transduction_Homo sapiens_hsa047400.95787753
49Nucleotide excision repair_Homo sapiens_hsa034200.91032428
50Cocaine addiction_Homo sapiens_hsa050300.90114706
51Ether lipid metabolism_Homo sapiens_hsa005650.89606778
52Pentose phosphate pathway_Homo sapiens_hsa000300.89038873
53Amphetamine addiction_Homo sapiens_hsa050310.86065895
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84356171
55Basal transcription factors_Homo sapiens_hsa030220.83065772
56Carbon metabolism_Homo sapiens_hsa012000.81922916
57p53 signaling pathway_Homo sapiens_hsa041150.79592752
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.78235266
59Renin secretion_Homo sapiens_hsa049240.76923284
60Oxytocin signaling pathway_Homo sapiens_hsa049210.76160085
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75831207
62Oocyte meiosis_Homo sapiens_hsa041140.71899462
63Arginine and proline metabolism_Homo sapiens_hsa003300.71390465
64Long-term depression_Homo sapiens_hsa047300.71360292
65Metabolic pathways_Homo sapiens_hsa011000.70846025
66N-Glycan biosynthesis_Homo sapiens_hsa005100.70309118
67Long-term potentiation_Homo sapiens_hsa047200.68160255
68Folate biosynthesis_Homo sapiens_hsa007900.67833933
69Pyruvate metabolism_Homo sapiens_hsa006200.67668784
70Homologous recombination_Homo sapiens_hsa034400.66823204
71Fructose and mannose metabolism_Homo sapiens_hsa000510.65439553
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65400529
73Sulfur metabolism_Homo sapiens_hsa009200.65358695
74Non-homologous end-joining_Homo sapiens_hsa034500.64290533
75Gap junction_Homo sapiens_hsa045400.63558891
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63040872
77Salivary secretion_Homo sapiens_hsa049700.62793452
78Insulin secretion_Homo sapiens_hsa049110.60448258
79Purine metabolism_Homo sapiens_hsa002300.58478692
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57836432
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57477047
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57281451
83Pyrimidine metabolism_Homo sapiens_hsa002400.55190663
84Galactose metabolism_Homo sapiens_hsa000520.53756210
85Cell cycle_Homo sapiens_hsa041100.52241428
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52186515
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51736774
88mRNA surveillance pathway_Homo sapiens_hsa030150.51492544
89DNA replication_Homo sapiens_hsa030300.49898035
90Renal cell carcinoma_Homo sapiens_hsa052110.48911222
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48004214
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47702337
93Glutathione metabolism_Homo sapiens_hsa004800.47482772
94Base excision repair_Homo sapiens_hsa034100.46958570
95Steroid biosynthesis_Homo sapiens_hsa001000.46709742
96Sphingolipid metabolism_Homo sapiens_hsa006000.45220566
97ErbB signaling pathway_Homo sapiens_hsa040120.43601245
98Calcium signaling pathway_Homo sapiens_hsa040200.43537424
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42908507
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42858226
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40936135
102Rheumatoid arthritis_Homo sapiens_hsa053230.40091258
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.39491527
104Ras signaling pathway_Homo sapiens_hsa040140.39188938
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37873819
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36466511
107Regulation of autophagy_Homo sapiens_hsa041400.35066229
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34893337
109RNA transport_Homo sapiens_hsa030130.34272126
110Phagosome_Homo sapiens_hsa041450.34155030
111Bladder cancer_Homo sapiens_hsa052190.34058118
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32097142
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31929708
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31710963
115MAPK signaling pathway_Homo sapiens_hsa040100.31282822
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.31039375
117Fatty acid elongation_Homo sapiens_hsa000620.30906664
118Colorectal cancer_Homo sapiens_hsa052100.30881156
119Hippo signaling pathway_Homo sapiens_hsa043900.29948880
120Gastric acid secretion_Homo sapiens_hsa049710.28794221
121Wnt signaling pathway_Homo sapiens_hsa043100.28531368
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27915615
123Melanogenesis_Homo sapiens_hsa049160.27654731
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27612976
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27605034
126Peroxisome_Homo sapiens_hsa041460.27599827
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27094795
128RNA degradation_Homo sapiens_hsa030180.26609695
129Endocytosis_Homo sapiens_hsa041440.25378323
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25211425
131Epstein-Barr virus infection_Homo sapiens_hsa051690.24289575
132Melanoma_Homo sapiens_hsa052180.24121540
133Hedgehog signaling pathway_Homo sapiens_hsa043400.23962356
134cAMP signaling pathway_Homo sapiens_hsa040240.23685928
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.23586683
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.23181696
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22539657
138Circadian rhythm_Homo sapiens_hsa047100.22400085
139Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21809505
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20422052
141Arginine biosynthesis_Homo sapiens_hsa002200.18331068
142AMPK signaling pathway_Homo sapiens_hsa041520.18050889
143Notch signaling pathway_Homo sapiens_hsa043300.17842805
144Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17631219
145Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.17159400
146Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15427854
147Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.15047535
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.14585295
149Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13856200
150Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12693385
151Phenylalanine metabolism_Homo sapiens_hsa003600.12682035

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