HIST3H2BA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mucosal immune response (GO:0002385)8.87352819
2antibacterial humoral response (GO:0019731)8.52097163
3nucleosome assembly (GO:0006334)8.16517924
4DNA replication-dependent nucleosome organization (GO:0034723)8.16237043
5DNA replication-dependent nucleosome assembly (GO:0006335)8.16237043
6organ or tissue specific immune response (GO:0002251)8.02339946
7chromatin assembly (GO:0031497)7.88698857
8antimicrobial humoral response (GO:0019730)7.79658298
9regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022357.74548509
10protein-DNA complex assembly (GO:0065004)7.07838580
11nucleosome organization (GO:0034728)6.89288243
12citrulline metabolic process (GO:0000052)6.67983171
13mitochondrial fusion (GO:0008053)6.37960715
14arginine metabolic process (GO:0006525)6.24432397
15protein-DNA complex subunit organization (GO:0071824)6.14967231
16nitric oxide mediated signal transduction (GO:0007263)5.55939886
17nitric oxide biosynthetic process (GO:0006809)5.55122184
18regulation of ruffle assembly (GO:1900027)5.45841039
19chromatin assembly or disassembly (GO:0006333)5.44040362
20regulation of histone H3-K9 methylation (GO:0051570)5.43864780
21forebrain neuron development (GO:0021884)5.21191228
22erythrocyte maturation (GO:0043249)5.17775395
23spinal cord development (GO:0021510)5.13269998
24cardiovascular system development (GO:0072358)5.03745581
25DNA unwinding involved in DNA replication (GO:0006268)4.95667312
26DNA strand elongation involved in DNA replication (GO:0006271)4.90771508
27DNA strand elongation (GO:0022616)4.73712499
28peptidyl-arginine omega-N-methylation (GO:0035247)4.73379038
29regulation of cholesterol esterification (GO:0010872)4.60051378
30nuclear pore complex assembly (GO:0051292)4.51826716
31protein localization to chromosome, centromeric region (GO:0071459)4.50683805
32viral protein processing (GO:0019082)4.49636270
33substrate-independent telencephalic tangential migration (GO:0021826)4.44697839
34substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.44697839
35mRNA modification (GO:0016556)4.38592223
36telomere maintenance via semi-conservative replication (GO:0032201)4.38550784
37regulation of ARF GTPase activity (GO:0032312)4.35709762
38cellular response to zinc ion (GO:0071294)4.33390602
39positive regulation of dendritic spine morphogenesis (GO:0061003)4.29425747
40mitotic sister chromatid segregation (GO:0000070)4.24550673
41viral mRNA export from host cell nucleus (GO:0046784)4.21085830
42protein localization to cilium (GO:0061512)4.19151519
43DNA replication initiation (GO:0006270)4.15675181
44immunoglobulin mediated immune response (GO:0016064)4.15152446
45peptidyl-arginine methylation (GO:0018216)4.07156284
46peptidyl-arginine N-methylation (GO:0035246)4.07156284
47nuclear pore organization (GO:0006999)4.06662894
48neuronal ion channel clustering (GO:0045161)4.06214169
49female gonad development (GO:0008585)4.03595919
50neuronal action potential propagation (GO:0019227)4.03567867
51regulation of neuron migration (GO:2001222)4.02751274
52sister chromatid segregation (GO:0000819)4.00306111
53acetyl-CoA metabolic process (GO:0006084)3.98623125
54positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.97678958
55mitotic chromosome condensation (GO:0007076)3.92609236
56positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.90717816
57cell morphogenesis involved in neuron differentiation (GO:0048667)3.88694199
58pyrimidine nucleobase catabolic process (GO:0006208)3.88575277
59isoprenoid biosynthetic process (GO:0008299)3.87497198
60regulation of oxidative phosphorylation (GO:0002082)3.85898304
61telomere maintenance via recombination (GO:0000722)3.83892188
62establishment of epithelial cell polarity (GO:0090162)3.83679628
63dendritic spine morphogenesis (GO:0060997)3.83396273
64B cell mediated immunity (GO:0019724)3.79327560
65cilium morphogenesis (GO:0060271)3.79287728
66B cell proliferation (GO:0042100)3.77050755
67regulation of ARF protein signal transduction (GO:0032012)3.75594381
68CENP-A containing nucleosome assembly (GO:0034080)3.74644038
69regulation of p38MAPK cascade (GO:1900744)3.70869984
70glutamine family amino acid catabolic process (GO:0009065)3.70701478
71inner mitochondrial membrane organization (GO:0007007)3.69452367
72chromatin remodeling at centromere (GO:0031055)3.69426732
73synaptic vesicle exocytosis (GO:0016079)3.67885013
74negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.66576943
75negative regulation of organelle assembly (GO:1902116)3.65293700
76central nervous system neuron development (GO:0021954)3.63718903
77axonal fasciculation (GO:0007413)3.63511960
78cerebral cortex neuron differentiation (GO:0021895)3.63013047
79ventricular system development (GO:0021591)3.62096898
80mitotic recombination (GO:0006312)3.60387677
81neuron cell-cell adhesion (GO:0007158)3.59404400
82neuron recognition (GO:0008038)3.57707531
83forebrain neuron differentiation (GO:0021879)3.57606224
84defense response to Gram-positive bacterium (GO:0050830)3.56800128
85B cell receptor signaling pathway (GO:0050853)3.56507734
86mitochondrial fission (GO:0000266)3.54605578
87tongue development (GO:0043586)3.52592798
88regulation of protein kinase C signaling (GO:0090036)3.52152922
89histone arginine methylation (GO:0034969)3.51121874
90establishment of viral latency (GO:0019043)3.50025433
91negative regulation of B cell apoptotic process (GO:0002903)3.47865653
92dendrite morphogenesis (GO:0048813)3.47639911
93mitotic nuclear envelope disassembly (GO:0007077)3.43726563
94pore complex assembly (GO:0046931)3.38216599
95protein localization to kinetochore (GO:0034501)3.37557451
96lysosome localization (GO:0032418)3.33907586
97myelin assembly (GO:0032288)3.32394698
98epithelial cilium movement (GO:0003351)3.31938824
99regulation of skeletal muscle cell differentiation (GO:2001014)3.20448901
100cranial nerve morphogenesis (GO:0021602)3.19493402
101membrane disassembly (GO:0030397)3.18769674
102nuclear envelope disassembly (GO:0051081)3.18769674
103protein localization to synapse (GO:0035418)3.18601941
104antigen processing and presentation of endogenous antigen (GO:0019883)3.18575988
105G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.16642678
106regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.16244280
107nucleotide-excision repair, DNA gap filling (GO:0006297)3.14800788
108establishment of integrated proviral latency (GO:0075713)3.13257343
109negative regulation of catenin import into nucleus (GO:0035414)3.10956376
110positive regulation of dendritic spine development (GO:0060999)3.10956368
111antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.10298277
112T-helper 1 type immune response (GO:0042088)3.09858099
113regulation of B cell receptor signaling pathway (GO:0050855)3.09648321
114synaptic vesicle maturation (GO:0016188)3.09426395
115regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.08279309
116V(D)J recombination (GO:0033151)3.06608033
117seminiferous tubule development (GO:0072520)3.06354506
118keratinocyte development (GO:0003334)3.04982518
119innervation (GO:0060384)3.00119754
120nucleobase catabolic process (GO:0046113)2.99568176
121regulation of mitochondrial translation (GO:0070129)2.99103353
122kinetochore organization (GO:0051383)2.99011056
123ATP-dependent chromatin remodeling (GO:0043044)2.97877472
124mitochondrial calcium ion transport (GO:0006851)2.96220146
125mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.95395293
126double-strand break repair via nonhomologous end joining (GO:0006303)2.94425527
127non-recombinational repair (GO:0000726)2.94425527
128proline biosynthetic process (GO:0006561)2.93205262
129mitotic metaphase plate congression (GO:0007080)2.92782488
130hematopoietic stem cell differentiation (GO:0060218)2.92503442
131regulation of interferon-gamma biosynthetic process (GO:0045072)2.90991919
132DNA ligation (GO:0006266)2.90357663
133mitotic sister chromatid cohesion (GO:0007064)2.89242653
134spliceosomal tri-snRNP complex assembly (GO:0000244)2.88505807
135negative regulation of microtubule polymerization (GO:0031115)2.88485364
136positive regulation of synapse assembly (GO:0051965)2.88078772
137hair cell differentiation (GO:0035315)2.87792438
138regulation of B cell apoptotic process (GO:0002902)2.87261542
139DNA duplex unwinding (GO:0032508)2.87166633
140central nervous system projection neuron axonogenesis (GO:0021952)2.86328958
141postsynaptic membrane organization (GO:0001941)2.85017189
142calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.84379378
143negative regulation of B cell proliferation (GO:0030889)2.83935334
144protoporphyrinogen IX biosynthetic process (GO:0006782)2.83718447
145telomere maintenance via telomere lengthening (GO:0010833)2.83183256
146antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.82675698
147ionotropic glutamate receptor signaling pathway (GO:0035235)2.82418444
148negative regulation of glial cell proliferation (GO:0060253)2.82203914
149maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.82180599
150axon cargo transport (GO:0008088)2.81556923
151DNA replication-independent nucleosome assembly (GO:0006336)2.81080169
152DNA replication-independent nucleosome organization (GO:0034724)2.81080169
153telomere maintenance (GO:0000723)2.80889592
154negative thymic T cell selection (GO:0045060)2.80646940
155regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.80625566
156positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.78656627
157protein localization to chromosome (GO:0034502)2.78493548
158metanephric mesenchyme development (GO:0072075)2.78107739
159telomere organization (GO:0032200)2.77731402
160sequestering of actin monomers (GO:0042989)2.77618209
161DNA geometric change (GO:0032392)2.77141213
162protein-DNA complex disassembly (GO:0032986)2.76273330
163nucleosome disassembly (GO:0006337)2.76273330
164negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.75153767
165B cell homeostasis (GO:0001782)2.74830333
166kinetochore assembly (GO:0051382)2.74167681
1677-methylguanosine mRNA capping (GO:0006370)2.73965934
168T cell migration (GO:0072678)2.73456499
169hippocampus development (GO:0021766)2.72555850
170regulation of megakaryocyte differentiation (GO:0045652)2.72420444
171regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.70578652
172cerebral cortex cell migration (GO:0021795)2.70177276
173presynaptic membrane assembly (GO:0097105)2.69427178
174negative T cell selection (GO:0043383)2.67328151
175regulation of short-term neuronal synaptic plasticity (GO:0048172)2.67303935
176cholesterol biosynthetic process (GO:0006695)2.66294301
177spermatid nucleus differentiation (GO:0007289)2.65431025
178humoral immune response (GO:0006959)2.64859656
179positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.64734531
180regulation of dendritic spine morphogenesis (GO:0061001)2.64512243
181response to dietary excess (GO:0002021)2.64485749
182glycogen biosynthetic process (GO:0005978)2.63893488
183glucan biosynthetic process (GO:0009250)2.63893488
184protoporphyrinogen IX metabolic process (GO:0046501)2.63691461
185histone exchange (GO:0043486)2.62497592
186regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.60786885
187establishment of mitochondrion localization (GO:0051654)2.60730618
188positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.59237636
189positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.59237636
190positive regulation of mitotic sister chromatid separation (GO:1901970)2.59237636
191regulation of chromosome segregation (GO:0051983)2.58345314
192DNA synthesis involved in DNA repair (GO:0000731)2.57982166
193positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.57771491
194somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.55379369
195arginine catabolic process (GO:0006527)11.0484956
196innate immune response in mucosa (GO:0002227)10.7349732

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat9.12762388
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.69647944
3E2F7_22180533_ChIP-Seq_HELA_Human6.11342949
4EZH2_22144423_ChIP-Seq_EOC_Human5.27472665
5E2F4_17652178_ChIP-ChIP_JURKAT_Human4.61645365
6AR_21572438_ChIP-Seq_LNCaP_Human4.26415525
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.75092184
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.70517251
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.12912572
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.99612279
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.93117689
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.65698589
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.55883533
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.48292504
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.35215348
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32367346
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.30500648
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.28323596
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.25568601
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.19454910
21* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.19405503
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.17578994
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.16132749
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11732029
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03119169
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.00918138
27GBX2_23144817_ChIP-Seq_PC3_Human1.97968197
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.97232581
29HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.96995817
30CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.96595159
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.93664823
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92053073
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90249378
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90249378
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.90043321
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89779497
37IRF1_19129219_ChIP-ChIP_H3396_Human1.87484500
38MYC_22102868_ChIP-Seq_BL_Human1.81959256
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78996478
40REST_21632747_ChIP-Seq_MESCs_Mouse1.77840032
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.76415597
42DROSHA_22980978_ChIP-Seq_HELA_Human1.76032968
43* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.75907319
44* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73756788
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.73448879
46* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.70268211
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66286194
48* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64819365
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63115158
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57871546
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.57555110
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.55782198
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.54599029
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54557530
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53980112
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.50707269
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.50608481
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50581214
59* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49388506
60* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47137651
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46986820
62SOX2_16153702_ChIP-ChIP_HESCs_Human1.44950829
63SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.43635673
64SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.42531074
65VDR_23849224_ChIP-Seq_CD4+_Human1.39207092
66NANOG_16153702_ChIP-ChIP_HESCs_Human1.36934635
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36888799
68IRF8_22096565_ChIP-ChIP_GC-B_Human1.36446936
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35972483
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34799448
71CIITA_25753668_ChIP-Seq_RAJI_Human1.34675890
72REST_18959480_ChIP-ChIP_MESCs_Mouse1.33980274
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32114563
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31625644
75* RARB_27405468_Chip-Seq_BRAIN_Mouse1.28456152
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28102297
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26645127
78RING1B_27294783_Chip-Seq_ESCs_Mouse1.25966267
79MYC_18358816_ChIP-ChIP_MESCs_Mouse1.25781691
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24742297
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.23092167
82VDR_21846776_ChIP-Seq_THP-1_Human1.21618077
83CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19064146
84MAF_26560356_Chip-Seq_TH1_Human1.19006049
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17652465
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17487751
87RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17422335
88GATA1_22025678_ChIP-Seq_K562_Human1.16903096
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16272420
90ELK4_26923725_Chip-Seq_MESODERM_Mouse1.16167813
91* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16105623
92MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15752206
93ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15562465
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15552036
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11940191
96MYC_18940864_ChIP-ChIP_HL60_Human1.11526652
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09585555
98* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09052473
99AR_21909140_ChIP-Seq_LNCAP_Human1.08868173
100RNF2_27304074_Chip-Seq_NSC_Mouse1.08709403
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08563617
102* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.08266695
103ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06576236
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06478229
105NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05308754
106HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04321491
107HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03686398
108ETS1_22383799_ChIP-Seq_G1ME_Mouse1.03342218
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02388406
110RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01293914
111XRN2_22483619_ChIP-Seq_HELA_Human1.00261919
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99520802
113NOTCH1_21737748_ChIP-Seq_TLL_Human0.99008917
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98988126
115KDM2B_26808549_Chip-Seq_K562_Human0.98431917
116ESR1_20079471_ChIP-ChIP_T-47D_Human0.98338949
117ELK1_19687146_ChIP-ChIP_HELA_Human0.96481743
118NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96417099
119ERA_21632823_ChIP-Seq_H3396_Human0.96388980
120EGR1_19374776_ChIP-ChIP_THP-1_Human0.95193217
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94711447
122PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93029481
123TP53_20018659_ChIP-ChIP_R1E_Mouse0.92814794
124FOXP3_21729870_ChIP-Seq_TREG_Human0.92254042
125CTCF_27219007_Chip-Seq_Bcells_Human0.92181455
126JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.91243134
127EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91110385
128MYC_19079543_ChIP-ChIP_MESCs_Mouse0.89844386
129RUNX1_26923725_Chip-Seq_HPCs_Mouse0.89452254
130PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88682383
131POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87413283
132SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86700774
133TAF15_26573619_Chip-Seq_HEK293_Human0.86538855
134BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86290140
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.85648933
136RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85202587
137EST1_17652178_ChIP-ChIP_JURKAT_Human0.84660362
138ETS1_20019798_ChIP-Seq_JURKAT_Human0.82707573
139WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.81634765
140MYB_26560356_Chip-Seq_TH1_Human0.80341326
141RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79716956
142CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78292934
143CTBP2_25329375_ChIP-Seq_LNCAP_Human0.77985005
144STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.77508549
145TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.77256404
146DCP1A_22483619_ChIP-Seq_HELA_Human0.76879712
147ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.76870677
148* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.76223922
149ETV2_25802403_ChIP-Seq_MESCs_Mouse0.75865901
150IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.75842271
151NR3C1_21868756_ChIP-Seq_MCF10A_Human0.75666580
152SMAD3_21741376_ChIP-Seq_EPCs_Human0.75297439
153SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.75083905
154TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74340596
155NANOG_18555785_Chip-Seq_ESCs_Mouse0.73913402
156REST_19997604_ChIP-ChIP_NEURONS_Mouse0.73834138
157SMAD4_21799915_ChIP-Seq_A2780_Human0.73453884
158TDRD3_21172665_ChIP-Seq_MCF-7_Human0.73293813
159PKCTHETA_26484144_Chip-Seq_BREAST_Human0.73237193
160MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.73187306
161GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72141011
162SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.72117691
163KLF5_20875108_ChIP-Seq_MESCs_Mouse0.72103706
164YY1_22570637_ChIP-Seq_MALME-3M_Human0.72075539
165P300_19829295_ChIP-Seq_ESCs_Human0.72033197
166ZFX_18555785_ChIP-Seq_MESCs_Mouse0.71432135
167DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.71284291
168PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.70981551
169UTX_26944678_Chip-Seq_JUKART_Human0.70724681
170NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.70203482
171MYB_26560356_Chip-Seq_TH2_Human0.70058017
172SOX2_21211035_ChIP-Seq_LN229_Gbm0.68229512
173CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.67307776
174ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.67055782
175ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66424701
176AR_19668381_ChIP-Seq_PC3_Human0.66285172
177NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.66230156
178RUNX2_22187159_ChIP-Seq_PCA_Human0.65452301
179YY1_21170310_ChIP-Seq_MESCs_Mouse0.65270010
180AR_25329375_ChIP-Seq_VCAP_Human0.64689312
181SOX3_22085726_ChIP-Seq_NPCs_Mouse0.64333144
182SMAD3_21741376_ChIP-Seq_HESCs_Human0.63269233
183MYCN_18555785_ChIP-Seq_MESCs_Mouse0.63147028
184STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.62956712
185TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.62095935
186SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.61852685
187TCF3_18692474_ChIP-Seq_MESCs_Mouse0.60367171
188GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.60138962
189E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.59668945
190ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.58071582

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.09709856
2MP0002009_preneoplasia4.29903840
3MP0003111_abnormal_nucleus_morphology4.08762525
4MP0008057_abnormal_DNA_replication4.05395365
5MP0003880_abnormal_central_pattern4.00472485
6MP0000685_abnormal_immune_system3.93334033
7MP0003077_abnormal_cell_cycle3.87812675
8MP0000013_abnormal_adipose_tissue3.85940293
9MP0003693_abnormal_embryo_hatching3.53803294
10MP0005671_abnormal_response_to3.44934168
11MP0003763_abnormal_thymus_physiology2.88828674
12MP0004957_abnormal_blastocyst_morpholog2.87098624
13MP0001835_abnormal_antigen_presentation2.81874819
14MP0006276_abnormal_autonomic_nervous2.77260070
15MP0003283_abnormal_digestive_organ2.69204344
16MP0002938_white_spotting2.67074929
17MP0004859_abnormal_synaptic_plasticity2.66781442
18MP0002102_abnormal_ear_morphology2.58228121
19MP0001800_abnormal_humoral_immune2.57092895
20MP0008058_abnormal_DNA_repair2.54895055
21MP0002090_abnormal_vision2.49874863
22MP0002063_abnormal_learning/memory/cond2.41402874
23MP0008789_abnormal_olfactory_epithelium2.38802656
24MP0002751_abnormal_autonomic_nervous2.34930329
25MP0004270_analgesia2.33460267
26MP0003635_abnormal_synaptic_transmissio2.31560793
27MP0005387_immune_system_phenotype2.27969841
28MP0001790_abnormal_immune_system2.27969841
29MP0002572_abnormal_emotion/affect_behav2.24155130
30MP0000778_abnormal_nervous_system2.18115177
31MP0002166_altered_tumor_susceptibility2.13679215
32MP0005499_abnormal_olfactory_system2.13467215
33MP0005394_taste/olfaction_phenotype2.13467215
34MP0009780_abnormal_chondrocyte_physiolo2.07596247
35MP0003183_abnormal_peptide_metabolism2.06723007
36MP0005257_abnormal_intraocular_pressure2.05747673
37MP0004742_abnormal_vestibular_system2.04166070
38MP0001529_abnormal_vocalization2.01698329
39MP0005000_abnormal_immune_tolerance1.98776705
40MP0001485_abnormal_pinna_reflex1.97073068
41MP0002398_abnormal_bone_marrow1.95972669
42MP0000350_abnormal_cell_proliferation1.92897779
43MP0002184_abnormal_innervation1.92023236
44MP0005171_absent_coat_pigmentation1.89034231
45MP0002067_abnormal_sensory_capabilities1.84694548
46MP0002272_abnormal_nervous_system1.77835867
47MP0002557_abnormal_social/conspecific_i1.76027813
48MP0005377_hearing/vestibular/ear_phenot1.74819523
49MP0003878_abnormal_ear_physiology1.74819523
50MP0008932_abnormal_embryonic_tissue1.73442123
51MP0001502_abnormal_circadian_rhythm1.73343686
52MP0002734_abnormal_mechanical_nocicepti1.71189681
53MP0009745_abnormal_behavioral_response1.70927943
54MP0005645_abnormal_hypothalamus_physiol1.69509001
55MP0005551_abnormal_eye_electrophysiolog1.68597978
56MP0006292_abnormal_olfactory_placode1.67551887
57MP0001968_abnormal_touch/_nociception1.66476912
58MP0002006_tumorigenesis1.66429058
59MP0001486_abnormal_startle_reflex1.64677571
60MP0002452_abnormal_antigen_presenting1.64369254
61MP0010352_gastrointestinal_tract_polyps1.64346850
62MP0000703_abnormal_thymus_morphology1.64127163
63MP0000566_synostosis1.63750434
64MP0005423_abnormal_somatic_nervous1.61454000
65MP0008007_abnormal_cellular_replicative1.59691082
66MP0005623_abnormal_meninges_morphology1.59626344
67MP0001727_abnormal_embryo_implantation1.58162613
68MP0002420_abnormal_adaptive_immunity1.56020904
69MP0002064_seizures1.55962334
70MP0002723_abnormal_immune_serum1.55721556
71MP0004811_abnormal_neuron_physiology1.55690487
72MP0000537_abnormal_urethra_morphology1.54299863
73MP0002882_abnormal_neuron_morphology1.54057153
74MP0002722_abnormal_immune_system1.53858093
75MP0002733_abnormal_thermal_nociception1.51634072
76MP0000689_abnormal_spleen_morphology1.51385328
77MP0009046_muscle_twitch1.50650642
78MP0002396_abnormal_hematopoietic_system1.50440143
79MP0003567_abnormal_fetal_cardiomyocyte1.49301204
80MP0001819_abnormal_immune_cell1.48954006
81MP0001346_abnormal_lacrimal_gland1.48575597
82MP0000716_abnormal_immune_system1.48572120
83MP0005253_abnormal_eye_physiology1.48325947
84MP0003122_maternal_imprinting1.45349906
85MP0002019_abnormal_tumor_incidence1.43836125
86MP0000313_abnormal_cell_death1.41853379
87MP0002735_abnormal_chemical_nociception1.41313401
88MP0001730_embryonic_growth_arrest1.38771419
89MP0002429_abnormal_blood_cell1.37877303
90MP0000003_abnormal_adipose_tissue1.37663831
91MP0001984_abnormal_olfaction1.37195577
92MP0003879_abnormal_hair_cell1.35487213
93MP0000490_abnormal_crypts_of1.32584460
94MP0001970_abnormal_pain_threshold1.30791549
95MP0000955_abnormal_spinal_cord1.30465138
96MP0003315_abnormal_perineum_morphology1.30346864
97MP0000631_abnormal_neuroendocrine_gland1.30319157
98MP0010234_abnormal_vibrissa_follicle1.29208122
99MP0002152_abnormal_brain_morphology1.28519284
100MP0005310_abnormal_salivary_gland1.27704466
101MP0001919_abnormal_reproductive_system1.23662121
102MP0010307_abnormal_tumor_latency1.23586718
103MP0006072_abnormal_retinal_apoptosis1.23254663
104MP0004885_abnormal_endolymph1.23167395
105MP0002822_catalepsy1.21799274
106MP0003786_premature_aging1.20300874
107MP0002736_abnormal_nociception_after1.19828966
108MP0002752_abnormal_somatic_nervous1.19670656
109MP0005248_abnormal_Harderian_gland1.18808429
110MP0009697_abnormal_copulation1.13013596
111MP0005195_abnormal_posterior_eye1.12386165
112MP0002138_abnormal_hepatobiliary_system1.10715212
113MP0001661_extended_life_span1.08033140
114MP0003935_abnormal_craniofacial_develop1.07211199
115MP0002066_abnormal_motor_capabilities/c1.07185805
116MP0002160_abnormal_reproductive_system1.06293707
117MP0008569_lethality_at_weaning1.05999725
118MP0003861_abnormal_nervous_system1.04897576
119MP0002163_abnormal_gland_morphology1.03758911
120MP0001440_abnormal_grooming_behavior1.03134972
121MP0003890_abnormal_embryonic-extraembry1.00426769
122MP0005389_reproductive_system_phenotype0.99921909
123MP0002080_prenatal_lethality0.99338548
124MP0005025_abnormal_response_to0.99195229
125MP0003634_abnormal_glial_cell0.98594997
126MP0005380_embryogenesis_phenotype0.97918086
127MP0001672_abnormal_embryogenesis/_devel0.97918086
128MP0002229_neurodegeneration0.97854393
129MP0002932_abnormal_joint_morphology0.96529661
130MP0004133_heterotaxia0.96410061
131MP0001963_abnormal_hearing_physiology0.95906659
132MP0003300_gastrointestinal_ulcer0.90932845
133MP0003119_abnormal_digestive_system0.90858445
134MP0003937_abnormal_limbs/digits/tail_de0.90535853
135MP0003115_abnormal_respiratory_system0.89639634
136MP0002638_abnormal_pupillary_reflex0.86841761
137MP0000026_abnormal_inner_ear0.86783970
138MP0005076_abnormal_cell_differentiation0.85889120
139MP0005220_abnormal_exocrine_pancreas0.84989337
140MP0004808_abnormal_hematopoietic_stem0.83835413
141MP0002081_perinatal_lethality0.83689035
142MP0003385_abnormal_body_wall0.83024265
143MP0003984_embryonic_growth_retardation0.82770046
144MP0005386_behavior/neurological_phenoty0.81426297
145MP0004924_abnormal_behavior0.81426297
146MP0001697_abnormal_embryo_size0.81063885
147MP0002085_abnormal_embryonic_tissue0.80448126
148MP0001845_abnormal_inflammatory_respons0.80006159
149MP0000428_abnormal_craniofacial_morphol0.79591360
150MP0002088_abnormal_embryonic_growth/wei0.79487155
151MP0004142_abnormal_muscle_tone0.78287500
152MP0003938_abnormal_ear_development0.76201837
153MP0009785_altered_susceptibility_to0.75678013
154MP0006035_abnormal_mitochondrial_morpho0.75464753
155MP0005187_abnormal_penis_morphology0.74289582
156MP0005084_abnormal_gallbladder_morpholo0.73357143
157MP0001348_abnormal_lacrimal_gland0.73312933
158MP0002837_dystrophic_cardiac_calcinosis0.72869091
159MP0000358_abnormal_cell_content/0.72768701
160MP0000751_myopathy0.70974368
161MP0003633_abnormal_nervous_system0.70313521
162MP0002697_abnormal_eye_size0.70201233
163MP0002086_abnormal_extraembryonic_tissu0.69232942
164MP0002210_abnormal_sex_determination0.68772369
165MP0010030_abnormal_orbit_morphology0.68601318
166MP0008961_abnormal_basal_metabolism0.68237440
167MP0002084_abnormal_developmental_patter0.67688386
168MP0009333_abnormal_splenocyte_physiolog0.67598272
169MP0003303_peritoneal_inflammation0.66866206
170MP0004197_abnormal_fetal_growth/weight/0.66447569
171MP0002083_premature_death0.66172537
172MP0002092_abnormal_eye_morphology0.65127431
173MP0003221_abnormal_cardiomyocyte_apopto0.63617888
174MP0002928_abnormal_bile_duct0.63435577
175MP0001664_abnormal_digestion0.63362016
176MP0005391_vision/eye_phenotype0.61974148
177MP0000049_abnormal_middle_ear0.61000645
178MP0000920_abnormal_myelination0.60993654
179MP0002405_respiratory_system_inflammati0.60906542
180MP0001293_anophthalmia0.60074089
181MP0005384_cellular_phenotype0.59628090
182MP0010155_abnormal_intestine_physiology0.59275571
183MP0002148_abnormal_hypersensitivity_rea0.54731497
184MP0005621_abnormal_cell_physiology0.54412351

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)7.47156707
2Peritonitis (HP:0002586)7.29673411
3Insidious onset (HP:0003587)7.20676858
4Termporal pattern (HP:0011008)7.20676858
5Progressive cerebellar ataxia (HP:0002073)7.15955255
6IgM deficiency (HP:0002850)7.01075786
7Elevated erythrocyte sedimentation rate (HP:0003565)6.89834754
8IgA deficiency (HP:0002720)6.57795256
9Central scotoma (HP:0000603)5.77362701
10Recurrent sinusitis (HP:0011108)5.45573750
11Dyschromatopsia (HP:0007641)5.25990883
12Recurrent bronchitis (HP:0002837)5.08087820
13Nephrogenic diabetes insipidus (HP:0009806)4.90438687
14Agammaglobulinemia (HP:0004432)4.88920521
15Renal tubular acidosis (HP:0001947)4.80720161
16Lymphopenia (HP:0001888)4.76626975
17Neuroendocrine neoplasm (HP:0100634)4.61659698
18Abnormality of cells of the lymphoid lineage (HP:0012140)4.51684972
19Progressive external ophthalmoplegia (HP:0000590)4.48354916
20Dry hair (HP:0011359)4.13020529
21Progressive sensorineural hearing impairment (HP:0000408)4.05845129
22Cellulitis (HP:0100658)4.02641150
23Abnormality of the peritoneum (HP:0002585)3.83798354
24Abnormal auditory evoked potentials (HP:0006958)3.80213600
25Pheochromocytoma (HP:0002666)3.62416123
26Emphysema (HP:0002097)3.61832611
27IgG deficiency (HP:0004315)3.61462501
28Limb dystonia (HP:0002451)3.49734544
29Meningitis (HP:0001287)3.48505692
30Hip dysplasia (HP:0001385)3.42757304
31Pancreatic cysts (HP:0001737)3.42679203
32Squamous cell carcinoma (HP:0002860)3.41902026
33Scotoma (HP:0000575)3.36615212
34Lissencephaly (HP:0001339)3.32852015
35Renal tubular dysfunction (HP:0000124)3.30273088
36Abnormality of DNA repair (HP:0003254)3.27182038
37Recurrent pneumonia (HP:0006532)3.21608392
38Basal cell carcinoma (HP:0002671)3.21443941
39Increased variability in muscle fiber diameter (HP:0003557)3.17292300
40Vasculitis (HP:0002633)3.12332873
41Chromosomal breakage induced by crosslinking agents (HP:0003221)3.01200687
42Shoulder girdle muscle weakness (HP:0003547)3.00231008
43Onycholysis (HP:0001806)3.00130361
44Colitis (HP:0002583)2.94394968
45Leukopenia (HP:0001882)2.93035806
46Recurrent lower respiratory tract infections (HP:0002783)2.86160103
47Urticaria (HP:0001025)2.85297738
48Lymphoma (HP:0002665)2.83096313
49Abnormal gallbladder physiology (HP:0012438)2.81495696
50Cholecystitis (HP:0001082)2.81495696
51Abnormality of skeletal muscle fiber size (HP:0012084)2.80699311
52Centrally nucleated skeletal muscle fibers (HP:0003687)2.80233143
53Rimmed vacuoles (HP:0003805)2.76889073
54Pelvic girdle muscle weakness (HP:0003749)2.75744702
55Entropion (HP:0000621)2.75685159
56Horizontal nystagmus (HP:0000666)2.74769653
57Gait imbalance (HP:0002141)2.73560119
58Hypertensive crisis (HP:0100735)2.72586004
59Renal Fanconi syndrome (HP:0001994)2.72358861
60Poikiloderma (HP:0001029)2.66832372
61Progressive hearing impairment (HP:0001730)2.66458556
62Bronchitis (HP:0012387)2.66205795
63True hermaphroditism (HP:0010459)2.60922491
64Hyperbilirubinemia (HP:0002904)2.59481295
65Chronic diarrhea (HP:0002028)2.58306354
66Abnormality of T cell physiology (HP:0011840)2.58081501
67Mediastinal lymphadenopathy (HP:0100721)2.57297373
68Sensory axonal neuropathy (HP:0003390)2.54966030
69Restrictive lung disease (HP:0002091)2.51456091
70Abnormality of the musculature of the pelvis (HP:0001469)2.49889812
71Abnormality of the hip-girdle musculature (HP:0001445)2.49889812
72Osteomyelitis (HP:0002754)2.49795150
73Congenital primary aphakia (HP:0007707)2.46513935
74Cortical dysplasia (HP:0002539)2.45408001
75Abnormality of the prostate (HP:0008775)2.43707743
76Abnormality of chromosome stability (HP:0003220)2.41473399
77B lymphocytopenia (HP:0010976)2.37907120
78Erythema (HP:0010783)2.36524224
79Conical tooth (HP:0000698)2.35737331
80Neoplasm of the peripheral nervous system (HP:0100007)2.35218624
81Recurrent viral infections (HP:0004429)2.34216091
82Specific learning disability (HP:0001328)2.33328992
83Abnormality of the preputium (HP:0100587)2.33162960
84Chromsome breakage (HP:0040012)2.32918565
85Myokymia (HP:0002411)2.32698149
86Poor speech (HP:0002465)2.32636621
87Eczematoid dermatitis (HP:0000976)2.32216330
88Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.30884977
89Recurrent otitis media (HP:0000403)2.28148424
90Ridged nail (HP:0001807)2.26630943
91Aplasia/Hypoplasia of the uvula (HP:0010293)2.25364199
92Medulloblastoma (HP:0002885)2.24299337
93Prostate neoplasm (HP:0100787)2.23523317
94Medial flaring of the eyebrow (HP:0010747)2.23026533
95Meckel diverticulum (HP:0002245)2.22049945
96Orthostatic hypotension (HP:0001278)2.21287786
97Posterior subcapsular cataract (HP:0007787)2.19648309
98Papilloma (HP:0012740)2.17496507
99Verrucae (HP:0200043)2.17496507
100Abnormality of the metopic suture (HP:0005556)2.15232909
101Abnormality of the ileum (HP:0001549)2.14608248
102Visual hallucinations (HP:0002367)2.14322144
103Deep palmar crease (HP:0006191)2.13634784
104Microvesicular hepatic steatosis (HP:0001414)2.12675872
105Skin rash (HP:0000988)2.10630727
106Premature loss of primary teeth (HP:0006323)2.09239389
107Sepsis (HP:0100806)2.08245277
108Congenital, generalized hypertrichosis (HP:0004540)2.05520772
109Gastrointestinal inflammation (HP:0004386)2.05379439
110Panhypogammaglobulinemia (HP:0003139)2.05172397
111Inflammation of the large intestine (HP:0002037)2.04735171
112Combined immunodeficiency (HP:0005387)2.04071665
113Prominent metopic ridge (HP:0005487)2.03961647
114Fragile nails (HP:0001808)2.03269427
115Large eyes (HP:0001090)2.02914603
116Hypohidrosis (HP:0000966)2.02267731
117Amblyopia (HP:0000646)2.02096998
118Cleft eyelid (HP:0000625)2.01573048
119Conjugated hyperbilirubinemia (HP:0002908)10.3287446
120Cone-rod dystrophy (HP:0000548)1.99087712
121Sparse scalp hair (HP:0002209)1.98649157
122Recurrent bacterial skin infections (HP:0005406)1.97062649
123Late onset (HP:0003584)1.96994325
124EEG with generalized epileptiform discharges (HP:0011198)1.95454978
125Hypsarrhythmia (HP:0002521)1.95180780
126Increased connective tissue (HP:0009025)1.94950379
127Abnormality of the carotid arteries (HP:0005344)1.94407038
128Aplasia/Hypoplasia of the sacrum (HP:0008517)1.93193243
129Megalencephaly (HP:0001355)1.93051057
130Epileptiform EEG discharges (HP:0011182)1.92222676
131Acrocyanosis (HP:0001063)1.92057468
132Epileptic encephalopathy (HP:0200134)1.91703882
133Increased hepatocellular lipid droplets (HP:0006565)1.91295240
134Abnormality of glycolysis (HP:0004366)1.89394300
135Vaginal atresia (HP:0000148)1.88144953
136Focal motor seizures (HP:0011153)1.87191754
137Abnormality of male internal genitalia (HP:0000022)1.83407309
138Tinnitus (HP:0000360)1.83356001
139Reticulocytopenia (HP:0001896)1.83131866
140Severe combined immunodeficiency (HP:0004430)1.83041959
141Optic disc pallor (HP:0000543)1.82572288
142Abnormality of B cell number (HP:0010975)1.82470146
143Hepatitis (HP:0012115)1.81360714
144Visceral angiomatosis (HP:0100761)1.80556094
145Steppage gait (HP:0003376)1.80221035
146Retinitis pigmentosa (HP:0000510)1.80081426
147Hyperacusis (HP:0010780)1.79594720
148Abnormality of pain sensation (HP:0010832)1.79430421
149Impaired pain sensation (HP:0007328)1.79430421
150Increased IgM level (HP:0003496)1.78841297
151Annular pancreas (HP:0001734)1.77101501
152Genital tract atresia (HP:0001827)1.76732261
153Choreoathetosis (HP:0001266)1.76426033
154Long palpebral fissure (HP:0000637)1.76083435
155Colon cancer (HP:0003003)1.75563913
156Decreased subcutaneous fat (HP:0001002)1.75346022
157Breast hypoplasia (HP:0003187)1.73878639
158Abnormality of the vocal cords (HP:0008777)1.73855697
159Cerebral hemorrhage (HP:0001342)1.73759263
160Fatigue (HP:0012378)1.72749120
161Clubbing of toes (HP:0100760)1.72736502
162External ophthalmoplegia (HP:0000544)1.72735759
163Abnormality of incisor morphology (HP:0011063)1.72509263
164Agitation (HP:0000713)1.72399142
165Failure to thrive in infancy (HP:0001531)1.71642749
166Pancreatic fibrosis (HP:0100732)1.70843431
167Nephrocalcinosis (HP:0000121)1.70818548
168Horseshoe kidney (HP:0000085)1.70475097
169Generalized tonic-clonic seizures (HP:0002069)1.70353703
170Aplasia/Hypoplasia of the lens (HP:0008063)1.69017467
171Abnormality of T cells (HP:0002843)1.68395334
172Rocker bottom foot (HP:0001838)1.68292128
173Neutropenia (HP:0001875)1.67224634
174Vertigo (HP:0002321)1.66223556
175Cutaneous photosensitivity (HP:0000992)1.66179165
176Polycythemia (HP:0001901)1.66098474
177Birth length less than 3rd percentile (HP:0003561)1.64823893
178Abnormality of the duodenum (HP:0002246)1.64268968
179Nephroblastoma (Wilms tumor) (HP:0002667)1.64200341
180Duodenal stenosis (HP:0100867)1.64129455
181Small intestinal stenosis (HP:0012848)1.64129455
182Abnormality of chromosome segregation (HP:0002916)1.63898528
183Insomnia (HP:0100785)1.63724248
184Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.63676952
185Neoplasm of the adrenal cortex (HP:0100641)1.63542366
186Hemangiomatosis (HP:0007461)1.62683986
187Intestinal atresia (HP:0011100)1.62646498
188Lipid accumulation in hepatocytes (HP:0006561)1.60899137
189Elevated hepatic transaminases (HP:0002910)1.57960562
190Thyroiditis (HP:0100646)1.57280734

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.73434687
2NUAK15.71435603
3MAP3K113.91863470
4DAPK33.34997630
5MARK13.25776066
6DYRK32.99744309
7EPHB22.72133439
8NME22.47802698
9SMG12.40480188
10IRAK22.34616613
11CASK2.01147728
12STK41.99752174
13MAPK131.99375485
14MAP2K21.90697526
15BUB11.89790398
16CDC71.83940367
17LIMK11.83315808
18UHMK11.83169255
19DYRK21.71159734
20SGK2231.69759351
21SGK4941.69759351
22TAF11.58649043
23NTRK31.55204628
24HIPK21.49765716
25PLK21.46256762
26VRK21.45049040
27AURKB1.38835596
28PRKD21.38615127
29MKNK21.32526630
30STK111.29427092
31SGK21.29386741
32RPS6KA51.28674171
33MAP3K101.24603864
34INSRR1.21785094
35SRPK11.21312956
36RPS6KA41.20768105
37CAMK2B1.18844591
38BCKDK1.18589743
39MINK11.16331937
40NEK91.16193405
41EPHA41.13950213
42KSR11.13698584
43NTRK21.12310489
44VRK11.09362598
45PIM11.08280618
46IRAK41.07572176
47WNK31.04164677
48EEF2K1.01674669
49PHKG21.01427793
50PHKG11.01427793
51MAPK110.98077637
52TNIK0.94619813
53CDK140.93238536
54TAOK10.92346141
55BRAF0.91445105
56CHEK20.91216573
57TESK10.90965435
58NEK10.88375442
59TTK0.88112742
60PKN10.87934903
61MAP2K70.82806684
62RPS6KB20.81299911
63DYRK1B0.80017263
64CAMKK10.79815029
65MAP3K80.79332593
66PINK10.79285790
67CAMK2A0.78846039
68CDK50.77269033
69DYRK1A0.75406890
70MAP4K10.74997336
71AURKA0.72107152
72CDK120.71442957
73ERBB20.71233908
74CAMK2D0.70916082
75WEE10.70121565
76PBK0.69400715
77PRKCZ0.69225715
78ATR0.69171120
79MAPK150.69154254
80CCNB10.69000511
81AKT20.68173906
82SGK10.66404655
83NME10.65532848
84MAP3K90.64601678
85OXSR10.64464441
86SGK30.64000090
87RPS6KA20.63684050
88CAMK40.63683043
89MKNK10.63130839
90MAP3K140.61943298
91PLK30.59836345
92CDK190.59587078
93DAPK20.58586729
94PAK60.58555631
95PRKAA10.58153293
96ICK0.56733913
97PRKCB0.56157295
98CDK70.56044338
99ZAK0.55819228
100TESK20.55586173
101PRKCE0.55520173
102ARAF0.55506766
103GRK50.55256071
104BRSK10.54440498
105NTRK10.53485253
106CDK180.53422989
107PRKCQ0.52974099
108BTK0.52959183
109CDK150.52788302
110SYK0.51991538
111MAPK90.47920998
112PLK10.47875472
113GSK3A0.47591971
114PRKCH0.46946774
115CHEK10.46877465
116STK390.46158147
117PRKCG0.46142474
118MAP3K40.45296456
119FGR0.43499750
120IKBKE0.43083145
121WNK40.42410538
122SIK20.42106883
123CSNK1G30.40992042
124CAMK2G0.40848093
125CDK40.40821998
126BLK0.40642830
127CSNK1A10.40454721
128TBK10.40254989
129ALK0.40131306
130MAP2K10.39181603
131CDK11A0.38877958
132MAPKAPK50.38496414
133LYN0.37654687
134EIF2AK30.37594333
135MAPK100.37114256
136PRKACA0.36894539
137EIF2AK20.36553181
138BRSK20.36419895
139FYN0.35309815
140PRKG10.35252982
141PRKD10.34542815
142NEK20.33476117
143CSNK1A1L0.33200975
144CDK20.32749967
145PLK40.31965999
146PASK0.30471829
147PAK30.29931374
148CSNK1G10.29734585
149FES0.29521545
150TSSK60.28188492
151KDR0.28055514
152STK100.28006898
153PAK10.26902879
154MAP3K130.26885795
155MST40.25759109
156IKBKB0.25380298
157ATM0.25298268
158CDK90.25224525
159SCYL20.24074016
160PRKCD0.22448362
161PIM20.22170748
162CSNK1G20.20430869
163CDK10.19862012
164JAK20.19177584
165FGFR40.17713356
166CSF1R0.16409329
167CDK80.15754130
168MELK0.15489580
169CSNK2A20.15263205
170MARK30.13712382
171DAPK10.10929256

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009006.02292621
2Systemic lupus erythematosus_Homo sapiens_hsa053224.52964169
3Alcoholism_Homo sapiens_hsa050343.47532859
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.18624783
5Nicotine addiction_Homo sapiens_hsa050332.55905142
6DNA replication_Homo sapiens_hsa030302.36951256
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.14406334
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.11775163
9Primary immunodeficiency_Homo sapiens_hsa053401.99740376
10Transcriptional misregulation in cancer_Homo sapiens_hsa052021.95950962
11Cocaine addiction_Homo sapiens_hsa050301.95388708
12Allograft rejection_Homo sapiens_hsa053301.92225481
13Circadian entrainment_Homo sapiens_hsa047131.85179224
14Axon guidance_Homo sapiens_hsa043601.84213336
15GABAergic synapse_Homo sapiens_hsa047271.83882982
16Asthma_Homo sapiens_hsa053101.81322033
17Autoimmune thyroid disease_Homo sapiens_hsa053201.80914000
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.77801085
19Sulfur relay system_Homo sapiens_hsa041221.76157021
20Taste transduction_Homo sapiens_hsa047421.75975190
21Amphetamine addiction_Homo sapiens_hsa050311.75544226
22Morphine addiction_Homo sapiens_hsa050321.75190883
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73916133
24Dopaminergic synapse_Homo sapiens_hsa047281.72109789
25Synaptic vesicle cycle_Homo sapiens_hsa047211.68785598
26Insulin secretion_Homo sapiens_hsa049111.63841355
27Mismatch repair_Homo sapiens_hsa034301.62757505
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62036076
29Dorso-ventral axis formation_Homo sapiens_hsa043201.60974528
30Glutamatergic synapse_Homo sapiens_hsa047241.58980782
31Graft-versus-host disease_Homo sapiens_hsa053321.55773809
32Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.48548591
33Olfactory transduction_Homo sapiens_hsa047401.47036257
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44953843
35Cholinergic synapse_Homo sapiens_hsa047251.43770446
36Type I diabetes mellitus_Homo sapiens_hsa049401.42890652
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.39648776
38Sulfur metabolism_Homo sapiens_hsa009201.32799004
39Viral myocarditis_Homo sapiens_hsa054161.31520623
40Long-term potentiation_Homo sapiens_hsa047201.28992251
41Gap junction_Homo sapiens_hsa045401.25695542
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19582071
43Base excision repair_Homo sapiens_hsa034101.15322607
44Melanogenesis_Homo sapiens_hsa049161.15028233
45Serotonergic synapse_Homo sapiens_hsa047261.13453903
46Renin secretion_Homo sapiens_hsa049241.13385085
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11300515
48Phototransduction_Homo sapiens_hsa047441.09313349
49Cell cycle_Homo sapiens_hsa041101.08636286
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07894093
51Non-homologous end-joining_Homo sapiens_hsa034501.03567701
52Antigen processing and presentation_Homo sapiens_hsa046121.02173957
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01384176
54Long-term depression_Homo sapiens_hsa047300.99294463
55B cell receptor signaling pathway_Homo sapiens_hsa046620.96713221
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95478466
57Tyrosine metabolism_Homo sapiens_hsa003500.95343911
58Spliceosome_Homo sapiens_hsa030400.93116806
59Oxytocin signaling pathway_Homo sapiens_hsa049210.89689773
60Ribosome_Homo sapiens_hsa030100.89475531
61Homologous recombination_Homo sapiens_hsa034400.89457716
62Renal cell carcinoma_Homo sapiens_hsa052110.88731549
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83900998
64Biosynthesis of amino acids_Homo sapiens_hsa012300.82206165
65Estrogen signaling pathway_Homo sapiens_hsa049150.81700556
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.81648138
67Herpes simplex infection_Homo sapiens_hsa051680.81400488
68Type II diabetes mellitus_Homo sapiens_hsa049300.80069408
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79762807
70Fanconi anemia pathway_Homo sapiens_hsa034600.79175451
71Salivary secretion_Homo sapiens_hsa049700.78746557
72Cardiac muscle contraction_Homo sapiens_hsa042600.78041449
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77555212
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76029662
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74990033
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74942354
77Pentose phosphate pathway_Homo sapiens_hsa000300.74674939
78Epstein-Barr virus infection_Homo sapiens_hsa051690.71993951
79cAMP signaling pathway_Homo sapiens_hsa040240.71555677
80Leishmaniasis_Homo sapiens_hsa051400.71190270
81Colorectal cancer_Homo sapiens_hsa052100.68856636
82Linoleic acid metabolism_Homo sapiens_hsa005910.67434736
83Viral carcinogenesis_Homo sapiens_hsa052030.67371459
84Glucagon signaling pathway_Homo sapiens_hsa049220.67247800
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66546444
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66293793
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66010679
88Glioma_Homo sapiens_hsa052140.66010178
89Prion diseases_Homo sapiens_hsa050200.64345566
90Alzheimers disease_Homo sapiens_hsa050100.63417068
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62652100
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62354946
93Oxidative phosphorylation_Homo sapiens_hsa001900.61445045
94One carbon pool by folate_Homo sapiens_hsa006700.60606041
95p53 signaling pathway_Homo sapiens_hsa041150.58706567
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57472040
97HTLV-I infection_Homo sapiens_hsa051660.55924929
98Carbon metabolism_Homo sapiens_hsa012000.55911044
99Nucleotide excision repair_Homo sapiens_hsa034200.55775996
100Collecting duct acid secretion_Homo sapiens_hsa049660.53815154
101Gastric acid secretion_Homo sapiens_hsa049710.53004073
102RNA transport_Homo sapiens_hsa030130.52383649
103Proteasome_Homo sapiens_hsa030500.49636891
104Basal transcription factors_Homo sapiens_hsa030220.49529436
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49345813
106Butanoate metabolism_Homo sapiens_hsa006500.49095779
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48864328
108Pyrimidine metabolism_Homo sapiens_hsa002400.48200268
109Oocyte meiosis_Homo sapiens_hsa041140.47189299
110Thyroid hormone synthesis_Homo sapiens_hsa049180.45769702
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44989054
112Parkinsons disease_Homo sapiens_hsa050120.44983705
113Vibrio cholerae infection_Homo sapiens_hsa051100.44895142
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43723464
115Circadian rhythm_Homo sapiens_hsa047100.43655590
116Dilated cardiomyopathy_Homo sapiens_hsa054140.42119620
117Influenza A_Homo sapiens_hsa051640.41168163
118Ether lipid metabolism_Homo sapiens_hsa005650.40922922
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40438178
120Peroxisome_Homo sapiens_hsa041460.39994513
121Endometrial cancer_Homo sapiens_hsa052130.39966613
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.39384509
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39315601
124Fructose and mannose metabolism_Homo sapiens_hsa000510.38474542
125Staphylococcus aureus infection_Homo sapiens_hsa051500.38306180
126ErbB signaling pathway_Homo sapiens_hsa040120.37694310
127Fat digestion and absorption_Homo sapiens_hsa049750.37608242
128Endocytosis_Homo sapiens_hsa041440.37332592
129mRNA surveillance pathway_Homo sapiens_hsa030150.35906844
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.35572042
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35376592
132Phenylalanine metabolism_Homo sapiens_hsa003600.34881063
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34457135
134Thyroid cancer_Homo sapiens_hsa052160.34319719
135Huntingtons disease_Homo sapiens_hsa050160.34212364
136Choline metabolism in cancer_Homo sapiens_hsa052310.33897592
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33585421
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33373743
139Hedgehog signaling pathway_Homo sapiens_hsa043400.33037648
140Calcium signaling pathway_Homo sapiens_hsa040200.32862405
141NF-kappa B signaling pathway_Homo sapiens_hsa040640.30872704
142Basal cell carcinoma_Homo sapiens_hsa052170.30415537
143Measles_Homo sapiens_hsa051620.30389604
144Bladder cancer_Homo sapiens_hsa052190.29011921
145Apoptosis_Homo sapiens_hsa042100.28588619
146Wnt signaling pathway_Homo sapiens_hsa043100.28013547
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27627277
148Lysine degradation_Homo sapiens_hsa003100.27492101
149Insulin signaling pathway_Homo sapiens_hsa049100.27482541
150Hematopoietic cell lineage_Homo sapiens_hsa046400.27005676
151RNA degradation_Homo sapiens_hsa030180.26930664
152Central carbon metabolism in cancer_Homo sapiens_hsa052300.26423532
153Hepatitis B_Homo sapiens_hsa051610.24428553
154Rheumatoid arthritis_Homo sapiens_hsa053230.24365713
155Cysteine and methionine metabolism_Homo sapiens_hsa002700.23636087
156Purine metabolism_Homo sapiens_hsa002300.18589175
157Non-small cell lung cancer_Homo sapiens_hsa052230.18321044
158RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18037071
159Toxoplasmosis_Homo sapiens_hsa051450.15778537
160Pyruvate metabolism_Homo sapiens_hsa006200.15526762
161Selenocompound metabolism_Homo sapiens_hsa004500.15122836
162RNA polymerase_Homo sapiens_hsa030200.14659291
163Tuberculosis_Homo sapiens_hsa051520.14121418
164Phagosome_Homo sapiens_hsa041450.12544469
165Vitamin B6 metabolism_Homo sapiens_hsa007500.12528883
166Cyanoamino acid metabolism_Homo sapiens_hsa004600.11625333
167Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.11465641
168Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.11447159
169Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10917097
170Pancreatic cancer_Homo sapiens_hsa052120.10688637
171Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.07326589
172MicroRNAs in cancer_Homo sapiens_hsa052060.07184314
173N-Glycan biosynthesis_Homo sapiens_hsa005100.06869903
174Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.06857306
175Galactose metabolism_Homo sapiens_hsa000520.06630344
176Chronic myeloid leukemia_Homo sapiens_hsa052200.06067106
177Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.04730421
178Propanoate metabolism_Homo sapiens_hsa006400.03273610
179Toll-like receptor signaling pathway_Homo sapiens_hsa046200.03160719
180Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.02267059
181Shigellosis_Homo sapiens_hsa051310.01622915

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