HIST3H3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of catecholamine secretion (GO:0033605)9.91688351
2synapsis (GO:0007129)9.47619644
3spermatid development (GO:0007286)8.53999988
4acrosome reaction (GO:0007340)8.26775687
5binding of sperm to zona pellucida (GO:0007339)7.66840540
6regulation of oxidative stress-induced neuron death (GO:1903203)7.61208116
7sperm motility (GO:0030317)7.55422345
8motile cilium assembly (GO:0044458)7.08857827
9regulation of oxidative phosphorylation (GO:0002082)7.04612186
10protein-DNA complex disassembly (GO:0032986)6.91491813
11nucleosome disassembly (GO:0006337)6.91491813
12chromosome organization involved in meiosis (GO:0070192)6.67434373
13multicellular organism reproduction (GO:0032504)6.66209120
14potassium ion export (GO:0071435)6.49980949
15relaxation of smooth muscle (GO:0044557)6.44821686
16sperm-egg recognition (GO:0035036)5.97725321
17piRNA metabolic process (GO:0034587)5.94914951
18axonemal dynein complex assembly (GO:0070286)5.84641926
19meiotic nuclear division (GO:0007126)5.66095797
20cilium or flagellum-dependent cell motility (GO:0001539)5.56215071
21polyamine biosynthetic process (GO:0006596)5.53273172
22Leydig cell differentiation (GO:0033327)5.49462351
23organic cation transport (GO:0015695)5.48580796
24male sex determination (GO:0030238)5.27839275
25cGMP-mediated signaling (GO:0019934)5.27829539
26germ cell development (GO:0007281)5.24656925
27activation of protein kinase B activity (GO:0032148)5.24549533
28negative regulation of hydrogen peroxide-induced cell death (GO:1903206)5.23920632
29cell-cell recognition (GO:0009988)5.21265312
30DNA methylation involved in gamete generation (GO:0043046)5.15753923
31regulation of hydrogen peroxide-induced cell death (GO:1903205)5.14666995
32synaptonemal complex assembly (GO:0007130)5.13923845
33TOR signaling (GO:0031929)4.98191606
34glutamine family amino acid catabolic process (GO:0009065)4.82450511
35tongue development (GO:0043586)4.76534618
36negative regulation of response to reactive oxygen species (GO:1901032)4.75500858
37epithelial cilium movement (GO:0003351)4.74738800
38regulation of dopamine secretion (GO:0014059)4.71963321
39synaptonemal complex organization (GO:0070193)4.64579388
40regulation of autophagic vacuole assembly (GO:2000785)4.59729565
41protein polymerization (GO:0051258)4.59282864
42histone H3-K9 demethylation (GO:0033169)4.58271233
43DNA synthesis involved in DNA repair (GO:0000731)4.58079524
44reproduction (GO:0000003)4.57935665
45oogenesis (GO:0048477)4.57859706
46glycogen metabolic process (GO:0005977)4.54062423
47cellular glucan metabolic process (GO:0006073)4.49331187
48glucan metabolic process (GO:0044042)4.49331187
49histone exchange (GO:0043486)4.48199984
50dicarboxylic acid biosynthetic process (GO:0043650)4.47277973
51regulation of cellular respiration (GO:0043457)4.44090824
52single fertilization (GO:0007338)4.37149626
53androgen biosynthetic process (GO:0006702)4.33820225
54histone H3-K36 demethylation (GO:0070544)4.32453424
55negative regulation of inclusion body assembly (GO:0090084)4.26976879
56negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.24051707
57positive regulation of glycolytic process (GO:0045821)4.22658822
58mitochondrion degradation (GO:0000422)4.18668458
59cellular process involved in reproduction in multicellular organism (GO:0022412)4.08678057
60response to acidic pH (GO:0010447)4.07651659
61membrane repolarization during action potential (GO:0086011)4.01918444
62ventricular system development (GO:0021591)3.98564499
63regulation of synaptic transmission, dopaminergic (GO:0032225)3.97351533
64fusion of sperm to egg plasma membrane (GO:0007342)3.97047754
65cilium movement (GO:0003341)3.82657803
66regulation of phosphatase activity (GO:0010921)3.82373843
67coenzyme catabolic process (GO:0009109)3.82189593
68cellular biogenic amine biosynthetic process (GO:0042401)3.81341329
69acrosome assembly (GO:0001675)3.79571606
70amine biosynthetic process (GO:0009309)3.78430198
71regulation of vacuole organization (GO:0044088)3.76435106
72diacylglycerol metabolic process (GO:0046339)3.67089950
73negative regulation of smooth muscle contraction (GO:0045986)3.66203339
74positive regulation of amine transport (GO:0051954)3.65404453
75phosphatidylethanolamine biosynthetic process (GO:0006646)3.64373689
76aspartate family amino acid catabolic process (GO:0009068)3.54488001
77fertilization (GO:0009566)3.54177610
78calcium ion-dependent exocytosis (GO:0017156)3.53673371
79male meiosis I (GO:0007141)3.53672414
80cellular response to toxic substance (GO:0097237)3.41940707
81DNA double-strand break processing (GO:0000729)3.40645718
82membrane repolarization (GO:0086009)3.37490240
83phosphatidylethanolamine metabolic process (GO:0046337)3.33322859
84negative regulation of JNK cascade (GO:0046329)3.30761800
85polyamine metabolic process (GO:0006595)3.27426169
86dicarboxylic acid catabolic process (GO:0043649)3.27199027
87plasma membrane fusion (GO:0045026)3.22940966
88female gamete generation (GO:0007292)3.22702217
89oligosaccharide biosynthetic process (GO:0009312)3.22436466
90regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.12516727
91cellular polysaccharide metabolic process (GO:0044264)3.12299200
92negative regulation of reactive oxygen species metabolic process (GO:2000378)3.11281688
93indole-containing compound catabolic process (GO:0042436)3.10963219
94indolalkylamine catabolic process (GO:0046218)3.10963219
95tryptophan catabolic process (GO:0006569)3.10963219
96genitalia morphogenesis (GO:0035112)3.10760493
97sex differentiation (GO:0007548)3.10018543
98male meiosis (GO:0007140)11.7680210
99positive regulation of synaptic transmission, dopaminergic (GO:0032226)10.8763811
100regulation of phosphoprotein phosphatase activity (GO:0043666)10.2748884

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.85621471
2IGF1R_20145208_ChIP-Seq_DFB_Human4.82323218
3VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human3.39024956
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.81120000
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.73188302
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.59791907
7FUS_26573619_Chip-Seq_HEK293_Human2.25536707
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08505456
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse12.1029836
10EZH2_22144423_ChIP-Seq_EOC_Human1.97827638
11AHR_22903824_ChIP-Seq_MCF-7_Human1.96817789
12ARNT_22903824_ChIP-Seq_MCF-7_Human1.93343645
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86779813
14AR_21572438_ChIP-Seq_LNCaP_Human1.85191117
15* ESR1_20079471_ChIP-ChIP_T-47D_Human1.78721171
16TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73076484
17POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.73076484
18ER_23166858_ChIP-Seq_MCF-7_Human1.72900064
19ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.71674101
20GBX2_23144817_ChIP-Seq_PC3_Human1.65932547
21NANOG_20526341_ChIP-Seq_ESCs_Human1.64893822
22BCAT_22108803_ChIP-Seq_LS180_Human1.64074126
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61252471
24AR_21909140_ChIP-Seq_LNCAP_Human1.60442454
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56563898
26GATA1_22025678_ChIP-Seq_K562_Human1.55864572
27RAC3_21632823_ChIP-Seq_H3396_Human1.52679223
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51547307
29ERA_21632823_ChIP-Seq_H3396_Human1.50023997
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43966984
31CBP_20019798_ChIP-Seq_JUKART_Human1.42500021
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42500021
33PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.41871136
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41542134
35CTCF_27219007_Chip-Seq_Bcells_Human1.41481248
36OCT4_20526341_ChIP-Seq_ESCs_Human1.40518512
37WDR5_24793694_ChIP-Seq_LNCAP_Human1.38985993
38OCT1_27270436_Chip-Seq_PROSTATE_Human1.36821079
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36478688
40SMC4_20622854_ChIP-Seq_HELA_Human1.31648164
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29322117
42KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29220143
43MYC_19829295_ChIP-Seq_ESCs_Human1.27860325
44SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26129095
45ERG_20517297_ChIP-Seq_VCAP_Human1.21851205
46TBL1_22424771_ChIP-Seq_293T_Human1.21485032
47RUNX2_22187159_ChIP-Seq_PCA_Human1.15309758
48TP53_18474530_ChIP-ChIP_U2OS_Human1.14137826
49SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13824555
50CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12468958
51P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11811727
52VDR_22108803_ChIP-Seq_LS180_Human1.10088723
53PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07614309
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06674038
55P300_19829295_ChIP-Seq_ESCs_Human1.04446778
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.04301488
57FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04084449
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02396775
59ZNF274_21170338_ChIP-Seq_K562_Hela1.01061542
60SMAD4_21799915_ChIP-Seq_A2780_Human1.00204688
61RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99292111
62EED_16625203_ChIP-ChIP_MESCs_Mouse0.99101600
63EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98319542
64MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96905418
65SMAD4_21741376_ChIP-Seq_EPCs_Human0.96700015
66PRDM14_20953172_ChIP-Seq_ESCs_Human0.95940977
67SPI1_20517297_ChIP-Seq_HL60_Human0.93788159
68RXR_22108803_ChIP-Seq_LS180_Human0.93434830
69IRF1_19129219_ChIP-ChIP_H3396_Human0.92641069
70SOX2_19829295_ChIP-Seq_ESCs_Human0.91995363
71NANOG_19829295_ChIP-Seq_ESCs_Human0.91995363
72P300_27268052_Chip-Seq_Bcells_Human0.91825902
73CTCF_20526341_ChIP-Seq_ESCs_Human0.89911752
74AR_25329375_ChIP-Seq_VCAP_Human0.89386983
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88933892
76P68_20966046_ChIP-Seq_HELA_Human0.86827343
77HOXB7_26014856_ChIP-Seq_BT474_Human0.86559026
78PHF8_20622854_ChIP-Seq_HELA_Human0.86198184
79TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.85441805
80IRF8_21731497_ChIP-ChIP_J774_Mouse0.85418730
81RAD21_21589869_ChIP-Seq_MESCs_Mouse0.83277390
82AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82889925
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82749120
84CBX2_27304074_Chip-Seq_ESCs_Mouse0.81995184
85STAT3_23295773_ChIP-Seq_U87_Human0.81316138
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.79974314
87SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.78641792
88TOP2B_26459242_ChIP-Seq_MCF-7_Human0.77983586
89PHF8_20622853_ChIP-Seq_HELA_Human0.77556663
90EGR1_23403033_ChIP-Seq_LIVER_Mouse0.77033973
91CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.75442635
92HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.74624269
93PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73667852
94FOXH1_21741376_ChIP-Seq_EPCs_Human0.73313145
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73057505
96* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.73048137
97TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.72728105
98E2F1_17053090_ChIP-ChIP_MCF-7_Human0.71848450
99NFYB_21822215_ChIP-Seq_K562_Human0.71703972
100E2F1_20622854_ChIP-Seq_HELA_Human0.70353606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.35818526
2MP0003315_abnormal_perineum_morphology7.13843035
3MP0008004_abnormal_stomach_pH6.45096409
4MP0002160_abnormal_reproductive_system4.45936145
5MP0005360_urolithiasis3.52277205
6MP0003698_abnormal_male_reproductive3.40356351
7MP0001929_abnormal_gametogenesis3.23859173
8MP0003045_fibrosis2.98019311
9MP0000537_abnormal_urethra_morphology2.74185956
10MP0003136_yellow_coat_color2.65045218
11MP0005058_abnormal_lysosome_morphology2.57158154
12MP0002210_abnormal_sex_determination2.37983899
13MP0001984_abnormal_olfaction2.35670118
14MP0010386_abnormal_urinary_bladder2.26694161
15MP0005389_reproductive_system_phenotype2.24801059
16MP0005647_abnormal_sex_gland2.22238210
17MP0002132_abnormal_respiratory_system2.07902698
18MP0010368_abnormal_lymphatic_system2.06998755
19MP0001664_abnormal_digestion2.03411115
20MP0001145_abnormal_male_reproductive2.00148041
21MP0008877_abnormal_DNA_methylation1.88814984
22MP0008995_early_reproductive_senescence1.86186153
23MP0000653_abnormal_sex_gland1.83640575
24MP0000538_abnormal_urinary_bladder1.77350440
25MP0002161_abnormal_fertility/fecundity1.76108432
26MP0005499_abnormal_olfactory_system1.74284008
27MP0005394_taste/olfaction_phenotype1.74284008
28MP0001661_extended_life_span1.71245901
29MP0001188_hyperpigmentation1.61794422
30MP0005187_abnormal_penis_morphology1.60049580
31MP0005409_darkened_coat_color1.44569968
32MP0009697_abnormal_copulation1.26550065
33MP0001849_ear_inflammation1.24502034
34MP0005174_abnormal_tail_pigmentation1.23829277
35MP0006072_abnormal_retinal_apoptosis1.23276636
36MP0000678_abnormal_parathyroid_gland1.22229675
37MP0001905_abnormal_dopamine_level1.21597745
38MP0005646_abnormal_pituitary_gland1.20564860
39MP0003936_abnormal_reproductive_system1.18454893
40MP0000465_gastrointestinal_hemorrhage1.15395093
41MP0004272_abnormal_basement_membrane1.09137289
42MP0001919_abnormal_reproductive_system1.07545246
43MP0003718_maternal_effect1.06430998
44MP0002249_abnormal_larynx_morphology1.01321923
45MP0006036_abnormal_mitochondrial_physio0.95596321
46MP0000631_abnormal_neuroendocrine_gland0.93382331
47MP0005395_other_phenotype0.92704170
48MP0000470_abnormal_stomach_morphology0.90826725
49MP0002127_abnormal_cardiovascular_syste0.88683963
50MP0008058_abnormal_DNA_repair0.88359067
51MP0003632_abnormal_nervous_system0.85256478
52MP0002168_other_aberrant_phenotype0.82081937
53MP0003693_abnormal_embryo_hatching0.81838576
54MP0004381_abnormal_hair_follicle0.81377779
55MP0004036_abnormal_muscle_relaxation0.76558069
56MP0001501_abnormal_sleep_pattern0.76227725
57MP0004085_abnormal_heartbeat0.73992865
58MP0001119_abnormal_female_reproductive0.70583005
59MP0010234_abnormal_vibrissa_follicle0.70560458
60MP0005253_abnormal_eye_physiology0.68160783
61MP0000343_altered_response_to0.65398665
62MP0002233_abnormal_nose_morphology0.63866770
63MP0003631_nervous_system_phenotype0.62656025
64MP0003385_abnormal_body_wall0.61561198
65MP0002638_abnormal_pupillary_reflex0.60352639
66MP0008789_abnormal_olfactory_epithelium0.59497069
67MP0003806_abnormal_nucleotide_metabolis0.58030402
68MP0000013_abnormal_adipose_tissue0.56195831
69MP0003699_abnormal_female_reproductive0.56081584
70MP0005248_abnormal_Harderian_gland0.55994525
71MP0000015_abnormal_ear_pigmentation0.55625465
72MP0002108_abnormal_muscle_morphology0.53601843
73MP0003119_abnormal_digestive_system0.52052384
74MP0009250_abnormal_appendicular_skeleto0.51370142
75MP0003879_abnormal_hair_cell0.51118130
76MP0005171_absent_coat_pigmentation0.50088383
77MP0005275_abnormal_skin_tensile0.49542063
78MP0004782_abnormal_surfactant_physiolog0.48511595
79MP0002282_abnormal_trachea_morphology0.48092523
80MP0003938_abnormal_ear_development0.47975278
81MP0000747_muscle_weakness0.47925690
82MP0003937_abnormal_limbs/digits/tail_de0.46514946
83MP0000049_abnormal_middle_ear0.45693489
84MP0001270_distended_abdomen0.45690652
85MP0005620_abnormal_muscle_contractility0.44610263
86MP0001756_abnormal_urination0.44308124
87MP0006035_abnormal_mitochondrial_morpho0.43764731
88MP0000230_abnormal_systemic_arterial0.42008795
89MP0002272_abnormal_nervous_system0.41531302
90MP0001764_abnormal_homeostasis0.41260371
91MP0002139_abnormal_hepatobiliary_system0.38969857
92MP0001968_abnormal_touch/_nociception0.38886865
93MP0004084_abnormal_cardiac_muscle0.38643333
94MP0003633_abnormal_nervous_system0.38510857
95MP0002998_abnormal_bone_remodeling0.36592184
96MP0005551_abnormal_eye_electrophysiolog0.35939448
97MP0000733_abnormal_muscle_development0.35489868
98MP0005595_abnormal_vascular_smooth0.35020684
99MP0001529_abnormal_vocalization0.33366614
100MP0004264_abnormal_extraembryonic_tissu0.33264839

Predicted human phenotypes

RankGene SetZ-score
1Abnormal sex determination (HP:0012244)7.71895652
2Sex reversal (HP:0012245)7.71895652
3Hypoplasia of the uterus (HP:0000013)7.49244429
4Resting tremor (HP:0002322)7.17983735
5Abnormality of the columella (HP:0009929)6.01852684
6Gonadal dysgenesis (HP:0000133)5.57034649
7Facial hemangioma (HP:0000329)5.48768158
8Aplasia/hypoplasia of the uterus (HP:0008684)5.44648943
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.35640091
10Reduced antithrombin III activity (HP:0001976)5.31518173
11Absent/shortened dynein arms (HP:0200106)5.25972979
12Dynein arm defect of respiratory motile cilia (HP:0012255)5.25972979
13Abnormal respiratory motile cilium physiology (HP:0012261)4.82607985
14Abnormal ciliary motility (HP:0012262)4.78587900
15Cerebellar dysplasia (HP:0007033)4.57425211
16Colitis (HP:0002583)4.52170115
17Male pseudohermaphroditism (HP:0000037)4.43895225
18Ventricular fibrillation (HP:0001663)4.28404711
19Postural instability (HP:0002172)4.23692800
20Infertility (HP:0000789)4.22093051
21Germ cell neoplasia (HP:0100728)4.16082078
22Capillary hemangiomas (HP:0005306)4.10737308
23Urinary urgency (HP:0000012)3.88306481
24Thoracic kyphosis (HP:0002942)3.80106280
25Abnormal respiratory epithelium morphology (HP:0012253)3.77086045
26Abnormal respiratory motile cilium morphology (HP:0005938)3.77086045
27Type II lissencephaly (HP:0007260)3.65994059
28Thoracolumbar scoliosis (HP:0002944)3.43618034
29Self-mutilation (HP:0000742)3.38312954
30Abnormality of the intrinsic pathway (HP:0010989)3.19248012
31Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.11209133
32Retinal atrophy (HP:0001105)3.09775359
33Inflammation of the large intestine (HP:0002037)3.07790500
34Protruding tongue (HP:0010808)3.01195431
35Abnormality of the lumbar spine (HP:0100712)3.01007358
36Abnormal protein glycosylation (HP:0012346)2.88836106
37Abnormal glycosylation (HP:0012345)2.88836106
38Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.88836106
39Abnormal protein N-linked glycosylation (HP:0012347)2.88836106
40Absent thumb (HP:0009777)2.85720330
41Gastrointestinal inflammation (HP:0004386)2.85195826
42Retinal dysplasia (HP:0007973)2.71329402
43Nasal polyposis (HP:0100582)2.68826754
44Abnormality of the frontal sinuses (HP:0002687)2.68804827
45Occipital encephalocele (HP:0002085)2.65544888
46Abnormality of the thoracic spine (HP:0100711)2.64581085
47Rhinitis (HP:0012384)2.61502852
48Congenital sensorineural hearing impairment (HP:0008527)2.54261341
49Sensory axonal neuropathy (HP:0003390)2.48676628
50Abnormality of male internal genitalia (HP:0000022)2.42041429
51Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.41246885
52Atonic seizures (HP:0010819)2.39933790
53High anterior hairline (HP:0009890)2.39671075
54Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.38893502
55Hypothermia (HP:0002045)2.37762650
56Buphthalmos (HP:0000557)2.31373280
57Abnormality of the nasal mucosa (HP:0000433)2.28623131
58Anterior segment dysgenesis (HP:0007700)2.25679064
59Abnormality of the ileum (HP:0001549)2.24312821
60Unsteady gait (HP:0002317)2.21448103
61Bronchiectasis (HP:0002110)2.14997652
62Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.11041969
63Decreased activity of mitochondrial respiratory chain (HP:0008972)2.11041969
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.09130872
65Ectopic kidney (HP:0000086)2.07983893
66Squamous cell carcinoma (HP:0002860)2.06868559
67Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05523653
68Prolonged QT interval (HP:0001657)2.02559233
69Meckel diverticulum (HP:0002245)2.02517286
70Syncope (HP:0001279)1.96989345
71Inability to walk (HP:0002540)1.95730204
72Absent speech (HP:0001344)1.91404994
73Facial diplegia (HP:0001349)1.91265503
74Spinal rigidity (HP:0003306)1.89111273
75Abnormality of DNA repair (HP:0003254)1.87462791
76Chronic hepatic failure (HP:0100626)1.86614723
77Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.83498950
78Difficulty climbing stairs (HP:0003551)1.82777988
79Tubulointerstitial nephritis (HP:0001970)1.75295166
80Polyneuropathy (HP:0001271)1.73403704
81Clubbing of toes (HP:0100760)1.71584408
82Coxa valga (HP:0002673)1.71088334
83Aortic aneurysm (HP:0004942)1.70209090
84Azoospermia (HP:0000027)1.69965602
85Generalized hypotonia (HP:0001290)1.64589210
86Vitreoretinal degeneration (HP:0000655)1.63707843
87Renal dysplasia (HP:0000110)1.62773878
88Hypoplasia of the radius (HP:0002984)1.62530771
89Abnormality of the preputium (HP:0100587)1.61912717
90Chronic bronchitis (HP:0004469)1.60923524
91Abnormality of chromosome stability (HP:0003220)1.59655687
92Optic nerve hypoplasia (HP:0000609)1.57143398
93Enlarged kidneys (HP:0000105)1.55975346
94Median cleft lip (HP:0000161)1.55627047
95Aplasia cutis congenita (HP:0001057)1.53727592
96Ureteral duplication (HP:0000073)1.52023473
97Abnormality of the dental root (HP:0006486)1.51500176
98Taurodontia (HP:0000679)1.51500176
99Abnormality of permanent molar morphology (HP:0011071)1.51500176
100Exercise-induced myalgia (HP:0003738)1.45222791

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK36.22196992
2ZAK4.93385629
3TLK14.67005342
4MYLK3.00946484
5NEK22.27631331
6PINK111.3925198
7LATS11.90435138
8STK381.69297896
9PNCK1.53033461
10STK38L1.49731363
11MAPK151.40033671
12VRK11.31361368
13MST1R1.28097982
14MAP2K71.24523897
15FGR1.16715718
16MET1.13184733
17CDK31.12086641
18MAP3K131.11633742
19LATS20.93053893
20SGK4940.93005339
21SGK2230.93005339
22ARAF0.91550733
23PRKCQ0.90446556
24PTK2B0.89086988
25MAP3K90.88696889
26FRK0.86200000
27DYRK30.83739521
28MELK0.82395732
29CSNK1A1L0.81786780
30CAMK1G0.70095656
31OBSCN0.68395707
32RET0.67676619
33CDK140.65583218
34BMPR1B0.65213296
35DAPK30.63763728
36MAP3K50.63559176
37CSNK1G30.61836909
38CDC42BPA0.61134764
39TIE10.60604074
40MAP3K10.59748112
41CSNK1G10.56854065
42MAP3K100.52750971
43RPS6KB10.51806434
44FGFR20.51699247
45PAK10.51171622
46PDPK10.49831106
47ROCK10.49353936
48CSNK1G20.47639392
49EGFR0.46945642
50PBK0.45567685
51PKN10.44654694
52ATM0.43636608
53CDK50.41555267
54AURKA0.39632205
55PDK10.38784001
56GRK10.36415704
57CAMK10.36007821
58OXSR10.34776616
59PDK20.34387552
60AKT20.33347019
61* RPS6KA50.32989482
62MOS0.32914004
63WNK10.31349682
64EIF2AK30.30710128
65CCNB10.30700257
66BRAF0.29947347
67PIM10.29249515
68PRKG10.28085801
69PAK20.26803771
70TAOK30.26767993
71PRKG20.25972545
72PDGFRB0.25280411
73NLK0.24664673
74CSNK1A10.24454762
75KDR0.24293607
76ADRBK20.23956603
77CDK120.23799623
78WNK40.23609006
79PLK10.22825994
80SGK20.22228672
81FES0.20032802
82ATR0.19089073
83AURKB0.18145276
84MTOR0.17420331
85STK40.16616358
86MAP4K10.16227522
87DYRK20.15823447
88RPS6KA10.15044885
89TGFBR10.14386045
90ICK0.14020814
91CDK90.13955554
92MAPK10.13350977
93CDK190.12888694
94PKN20.10193322
95MAPK120.09584872
96CSF1R0.07952032
97BLK0.07684083
98NME20.07157104
99AKT30.06923396
100EEF2K0.06485230

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051307.80357596
2Gap junction_Homo sapiens_hsa045405.26685966
3* Systemic lupus erythematosus_Homo sapiens_hsa053223.94001492
4Nitrogen metabolism_Homo sapiens_hsa009103.70746050
5Hedgehog signaling pathway_Homo sapiens_hsa043403.46465143
6Arginine biosynthesis_Homo sapiens_hsa002202.96749584
7Apoptosis_Homo sapiens_hsa042102.95662565
8* Alcoholism_Homo sapiens_hsa050342.79847636
9Phagosome_Homo sapiens_hsa041452.66869280
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.39851032
11Propanoate metabolism_Homo sapiens_hsa006402.14201543
12Olfactory transduction_Homo sapiens_hsa047401.94378882
13Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.89575077
14Steroid hormone biosynthesis_Homo sapiens_hsa001401.69755728
15Butanoate metabolism_Homo sapiens_hsa006501.60753447
16Pyruvate metabolism_Homo sapiens_hsa006201.52833780
17Glutathione metabolism_Homo sapiens_hsa004801.45931194
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43229920
19Dorso-ventral axis formation_Homo sapiens_hsa043201.39203809
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.32347309
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24293219
22Oocyte meiosis_Homo sapiens_hsa041141.13734212
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.11346378
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08869836
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05085722
26Fanconi anemia pathway_Homo sapiens_hsa034601.01795963
27Chemical carcinogenesis_Homo sapiens_hsa052041.01759937
28Fatty acid biosynthesis_Homo sapiens_hsa000611.00934283
29Vascular smooth muscle contraction_Homo sapiens_hsa042700.97275719
30cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94998627
31Glucagon signaling pathway_Homo sapiens_hsa049220.93159801
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87784223
33PPAR signaling pathway_Homo sapiens_hsa033200.85833440
34Viral carcinogenesis_Homo sapiens_hsa052030.83339961
35Basal transcription factors_Homo sapiens_hsa030220.82827192
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82806944
37mRNA surveillance pathway_Homo sapiens_hsa030150.81685714
38Phenylalanine metabolism_Homo sapiens_hsa003600.81564814
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81405611
40Renin secretion_Homo sapiens_hsa049240.77913971
41Taste transduction_Homo sapiens_hsa047420.76204747
42Pentose phosphate pathway_Homo sapiens_hsa000300.68771842
43N-Glycan biosynthesis_Homo sapiens_hsa005100.67615840
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67571351
45TGF-beta signaling pathway_Homo sapiens_hsa043500.67483046
46Circadian rhythm_Homo sapiens_hsa047100.65803395
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61798700
48Tryptophan metabolism_Homo sapiens_hsa003800.58125790
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55599678
50Oxytocin signaling pathway_Homo sapiens_hsa049210.54754305
51Calcium signaling pathway_Homo sapiens_hsa040200.54016961
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50833888
53RNA transport_Homo sapiens_hsa030130.50608600
54Fatty acid degradation_Homo sapiens_hsa000710.50540761
55Sulfur relay system_Homo sapiens_hsa041220.46937162
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.45702721
57Wnt signaling pathway_Homo sapiens_hsa043100.43326621
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40941891
59RNA degradation_Homo sapiens_hsa030180.40077274
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38889616
61beta-Alanine metabolism_Homo sapiens_hsa004100.37168321
62Retinol metabolism_Homo sapiens_hsa008300.36788409
63Gastric acid secretion_Homo sapiens_hsa049710.36483877
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34170509
65T cell receptor signaling pathway_Homo sapiens_hsa046600.33202306
66Regulation of autophagy_Homo sapiens_hsa041400.33014925
67Phototransduction_Homo sapiens_hsa047440.31252151
68Endometrial cancer_Homo sapiens_hsa052130.30529149
69Tyrosine metabolism_Homo sapiens_hsa003500.29605282
70B cell receptor signaling pathway_Homo sapiens_hsa046620.29010560
71Purine metabolism_Homo sapiens_hsa002300.28885895
72Choline metabolism in cancer_Homo sapiens_hsa052310.25978828
73Sphingolipid metabolism_Homo sapiens_hsa006000.25838315
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.23993204
75Selenocompound metabolism_Homo sapiens_hsa004500.21548707
76Vitamin digestion and absorption_Homo sapiens_hsa049770.21472355
77Prostate cancer_Homo sapiens_hsa052150.20494382
78MAPK signaling pathway_Homo sapiens_hsa040100.20232351
79Peroxisome_Homo sapiens_hsa041460.20101566
80ECM-receptor interaction_Homo sapiens_hsa045120.18920618
81Metabolic pathways_Homo sapiens_hsa011000.18916740
82Fatty acid metabolism_Homo sapiens_hsa012120.18644595
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17588220
84mTOR signaling pathway_Homo sapiens_hsa041500.17402602
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17243706
86Carbon metabolism_Homo sapiens_hsa012000.16881565
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.16024228
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.13983836
89DNA replication_Homo sapiens_hsa030300.12213735
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.11610428
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.11542231
92Tight junction_Homo sapiens_hsa045300.11445626
93Melanoma_Homo sapiens_hsa052180.11216063
94Herpes simplex infection_Homo sapiens_hsa051680.10625623
95Circadian entrainment_Homo sapiens_hsa047130.10474720
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.10100611
97Focal adhesion_Homo sapiens_hsa045100.08466195
98Protein digestion and absorption_Homo sapiens_hsa049740.08127795
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.06785241
100Long-term potentiation_Homo sapiens_hsa047200.06664916

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