HIST4H4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome organization (GO:0034723)8.73576186
2DNA replication-dependent nucleosome assembly (GO:0006335)8.73576186
3mucosal immune response (GO:0002385)8.40675312
4organ or tissue specific immune response (GO:0002251)7.60092891
5chromatin assembly (GO:0031497)7.19482550
6regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)6.89933583
7regulation of histone H3-K9 methylation (GO:0051570)6.19212962
8nucleosome assembly (GO:0006334)6.09337828
9chromatin assembly or disassembly (GO:0006333)6.02778840
10mitotic sister chromatid cohesion (GO:0007064)6.00390278
11mitotic chromosome condensation (GO:0007076)5.93789606
12protein localization to chromosome, centromeric region (GO:0071459)5.41231209
13nucleosome organization (GO:0034728)5.38445264
14nuclear pore complex assembly (GO:0051292)5.37209134
15DNA deamination (GO:0045006)5.34528500
16replicative senescence (GO:0090399)5.19190311
17protein-DNA complex assembly (GO:0065004)5.15746599
18protein localization to kinetochore (GO:0034501)4.85110853
19nuclear pore organization (GO:0006999)4.79980215
20microtubule depolymerization (GO:0007019)4.78778552
21protein-DNA complex subunit organization (GO:0071824)4.71244846
22histone H3-K36 demethylation (GO:0070544)4.70925044
23mitotic sister chromatid segregation (GO:0000070)4.65784852
24sister chromatid segregation (GO:0000819)4.63812663
25regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.44424397
26monoubiquitinated protein deubiquitination (GO:0035520)4.39385090
27kinetochore organization (GO:0051383)4.33285487
28positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)4.30235728
29somatic hypermutation of immunoglobulin genes (GO:0016446)4.22914259
30somatic diversification of immune receptors via somatic mutation (GO:0002566)4.22914259
31pore complex assembly (GO:0046931)4.17208024
32DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.10213413
33histone lysine demethylation (GO:0070076)4.01795931
34positive regulation of histone methylation (GO:0031062)3.98920196
35mitotic metaphase plate congression (GO:0007080)3.96295893
36regulation of spindle checkpoint (GO:0090231)3.93229880
37kinetochore assembly (GO:0051382)3.90478202
38maintenance of protein location in nucleus (GO:0051457)3.88573528
39histone demethylation (GO:0016577)3.88493622
40cytidine metabolic process (GO:0046087)3.87482609
41cytidine catabolic process (GO:0006216)3.87482609
42cytidine deamination (GO:0009972)3.87482609
43DNA packaging (GO:0006323)3.85693745
44viral mRNA export from host cell nucleus (GO:0046784)3.82900649
45meiotic chromosome segregation (GO:0045132)3.82011438
46regulation of RNA export from nucleus (GO:0046831)3.79995033
47regulation of gene silencing (GO:0060968)3.75678210
48negative regulation of histone methylation (GO:0031061)3.73176183
49protein K6-linked ubiquitination (GO:0085020)3.72775615
50sister chromatid cohesion (GO:0007062)3.72119397
51pre-miRNA processing (GO:0031054)3.69755664
52antibacterial humoral response (GO:0019731)3.66271043
53CENP-A containing nucleosome assembly (GO:0034080)3.64397938
54DNA damage response, signal transduction resulting in transcription (GO:0042772)3.62311972
55maturation of 5.8S rRNA (GO:0000460)3.60568308
56regulation of centriole replication (GO:0046599)3.59462781
57regulation of centrosome cycle (GO:0046605)3.59022620
58chromatin remodeling at centromere (GO:0031055)3.57523631
59chromosome condensation (GO:0030261)3.57175691
60DNA replication-independent nucleosome organization (GO:0034724)3.55265278
61DNA replication-independent nucleosome assembly (GO:0006336)3.55265278
62metaphase plate congression (GO:0051310)3.54827256
63histone H3-K9 methylation (GO:0051567)3.54638413
64spindle assembly involved in mitosis (GO:0090307)3.54231566
65regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)3.54003476
66pseudouridine synthesis (GO:0001522)3.50982609
67innate immune response in mucosa (GO:0002227)3.50630196
68regulation of DNA endoreduplication (GO:0032875)3.48085741
69regulation of megakaryocyte differentiation (GO:0045652)3.45833189
70histone H2B ubiquitination (GO:0033523)3.41543113
71defense response to Gram-positive bacterium (GO:0050830)3.37533324
72regulation of histone methylation (GO:0031060)3.37239668
73regulation of nucleobase-containing compound transport (GO:0032239)3.35213322
74histone exchange (GO:0043486)3.34626951
75regulation of mitotic spindle checkpoint (GO:1903504)3.34598584
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.34598584
77protein demethylation (GO:0006482)3.34316054
78protein dealkylation (GO:0008214)3.34316054
79pyrimidine ribonucleoside catabolic process (GO:0046133)3.33389079
80positive regulation of histone H3-K4 methylation (GO:0051571)3.32357824
81embryonic retina morphogenesis in camera-type eye (GO:0060059)3.29883100
82protein localization to chromosome (GO:0034502)3.29259103
83antimicrobial humoral response (GO:0019730)3.28641973
84regulation of cell cycle checkpoint (GO:1901976)3.20079434
85histone phosphorylation (GO:0016572)3.19638093
86histone H3-K9 modification (GO:0061647)3.17077745
87regulation of centrosome duplication (GO:0010824)3.14033404
88negative regulation of B cell proliferation (GO:0030889)3.13142402
89positive regulation of DNA-templated transcription, elongation (GO:0032786)3.11693516
90negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.08995442
91paraxial mesoderm development (GO:0048339)3.07023483
92chromosome segregation (GO:0007059)3.05284568
93regulation of spindle organization (GO:0090224)3.05095197
94establishment of chromosome localization (GO:0051303)3.04009405
95positive regulation of cell cycle checkpoint (GO:1901978)3.02081259
96histone H3-K4 trimethylation (GO:0080182)3.00551306
97regulation of helicase activity (GO:0051095)2.99041326
98regulation of hippo signaling (GO:0035330)2.98374999
99positive regulation of alpha-beta T cell proliferation (GO:0046641)2.98320117
100DNA replication initiation (GO:0006270)2.97636107
101histone monoubiquitination (GO:0010390)2.95646998
102regulation of exit from mitosis (GO:0007096)2.95039684
103DNA unwinding involved in DNA replication (GO:0006268)2.94924143
104regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.94461667
105DNA replication checkpoint (GO:0000076)2.93809424
106histone H4-K12 acetylation (GO:0043983)2.93086668
107somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.92218665
108somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.92218665
109isotype switching (GO:0045190)2.92218665
110prenylation (GO:0097354)2.91642616
111protein prenylation (GO:0018342)2.91642616
112regulation of mitotic spindle organization (GO:0060236)2.91550109
113microtubule polymerization or depolymerization (GO:0031109)2.89892477
114protein K11-linked deubiquitination (GO:0035871)2.88727336
115regulation of somitogenesis (GO:0014807)2.87127050
116negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.86859118
117histone H2A monoubiquitination (GO:0035518)2.86727019
118DNA conformation change (GO:0071103)2.86298297
119regulation of DNA damage checkpoint (GO:2000001)2.86286398
120regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.85466899
121ATP-dependent chromatin remodeling (GO:0043044)2.84042347
122replication fork processing (GO:0031297)2.82984654
123microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.82654490
124regulation of gene silencing by RNA (GO:0060966)2.82489464
125regulation of gene silencing by miRNA (GO:0060964)2.82489464
126somatic diversification of immunoglobulins (GO:0016445)2.80878678
127positive regulation of T cell mediated cytotoxicity (GO:0001916)2.78196662
128positive regulation of defense response to virus by host (GO:0002230)2.74349195
129somatic recombination of immunoglobulin gene segments (GO:0016447)2.72560614
130protein import into peroxisome matrix (GO:0016558)2.69531478
131mitochondrial RNA metabolic process (GO:0000959)2.67076824
132negative regulation of B cell apoptotic process (GO:0002903)2.66160840
133telomere organization (GO:0032200)2.64977693
134mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.62898177
135mitochondrial respiratory chain complex I assembly (GO:0032981)2.62898177
136NADH dehydrogenase complex assembly (GO:0010257)2.62898177
137telomere maintenance (GO:0000723)2.60942750
138transcription elongation from RNA polymerase I promoter (GO:0006362)2.60474270
139molting cycle (GO:0042303)2.60204162
140hair cycle (GO:0042633)2.60204162
141tRNA modification (GO:0006400)2.57636946
142histone-serine phosphorylation (GO:0035404)2.57394303
143sulfation (GO:0051923)2.57180199
144positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.55646170
145maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.55472602
146DNA double-strand break processing (GO:0000729)2.53093369
147endoderm formation (GO:0001706)2.51036140
148T cell lineage commitment (GO:0002360)2.50905802
149positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.47161006
150spleen development (GO:0048536)2.47029413
151B cell homeostasis (GO:0001782)2.43228715
152pyrimidine dimer repair (GO:0006290)2.41517919
153regulation of defense response to virus by host (GO:0050691)2.39014165
154RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.38832542
155DNA strand elongation involved in DNA replication (GO:0006271)2.38715099
156T-helper 1 type immune response (GO:0042088)2.38665079
157nucleotide transmembrane transport (GO:1901679)2.37478982
158double-strand break repair via homologous recombination (GO:0000724)2.37024749
159B cell receptor signaling pathway (GO:0050853)2.36465874
160mitochondrial respiratory chain complex assembly (GO:0033108)2.36166904
161T cell mediated immunity (GO:0002456)2.35071401
162recombinational repair (GO:0000725)2.34873103
163regulation of posttranscriptional gene silencing (GO:0060147)2.33614465
164protein K48-linked deubiquitination (GO:0071108)2.33418569
165reciprocal DNA recombination (GO:0035825)2.32503163
166reciprocal meiotic recombination (GO:0007131)2.32503163

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse8.58277111
2E2F7_22180533_ChIP-Seq_HELA_Human6.31683312
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.71506124
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.01151792
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.68432157
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.62288359
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48369980
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.45110979
9* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.32044162
10IRF1_19129219_ChIP-ChIP_H3396_Human2.29467753
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.26302863
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.16920368
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.11361022
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse15.4793479
15* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.99642815
16* SOX2_16153702_ChIP-ChIP_HESCs_Human1.95163490
17IGF1R_20145208_ChIP-Seq_DFB_Human1.85021645
18VDR_23849224_ChIP-Seq_CD4+_Human1.76346542
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.75139080
20MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72064907
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68342617
22HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.68220776
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65079257
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64517558
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60633364
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.55456196
27SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.54989270
28GATA1_22025678_ChIP-Seq_K562_Human1.51253959
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46155963
30AR_21909140_ChIP-Seq_LNCAP_Human1.44152533
31MYC_18940864_ChIP-ChIP_HL60_Human1.42893039
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33969724
33* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30695311
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.28600978
35* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.28251272
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26519359
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23850141
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23055370
39VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21497308
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21282065
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19390647
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.18413913
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17946472
44TCF3_18692474_ChIP-Seq_MESCs_Mouse1.17854436
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.16691450
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08928671
47* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08861303
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07881045
49EWS_26573619_Chip-Seq_HEK293_Human1.04791452
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02235125
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01656178
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01012543
53* NANOG_16153702_ChIP-ChIP_HESCs_Human1.00174616
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99906410
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99731171
56EST1_17652178_ChIP-ChIP_JURKAT_Human0.98793822
57GABP_17652178_ChIP-ChIP_JURKAT_Human0.97922178
58ZNF274_21170338_ChIP-Seq_K562_Hela0.96725739
59ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94837905
60* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93790716
61EZH2_27294783_Chip-Seq_NPCs_Mouse0.90285360
62ETS1_20019798_ChIP-Seq_JURKAT_Human0.89913655
63CIITA_25753668_ChIP-Seq_RAJI_Human0.89167777
64NANOG_18555785_Chip-Seq_ESCs_Mouse0.88216343
65TCF4_18268006_ChIP-ChIP_LS174T_Human0.87601339
66* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86971243
67PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86238169
68DCP1A_22483619_ChIP-Seq_HELA_Human0.85849801
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85676765
70SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84230985
71ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.83555098
72FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.81497515
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80895212
74TDRD3_21172665_ChIP-Seq_MCF-7_Human0.80587692
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.80055458
76E2F1_18555785_Chip-Seq_ESCs_Mouse0.78963394
77THAP11_20581084_ChIP-Seq_MESCs_Mouse0.77438118
78PADI4_21655091_ChIP-ChIP_MCF-7_Human0.76288120
79SUZ12_18555785_Chip-Seq_ESCs_Mouse0.74957372
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73590642
81FUS_26573619_Chip-Seq_HEK293_Human0.73295748
82ELK1_19687146_ChIP-ChIP_HELA_Human0.73274887
83* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.72526233
84PKCTHETA_26484144_Chip-Seq_BREAST_Human0.72394542
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.72311916
86OCT4_18555785_Chip-Seq_ESCs_Mouse0.72167123
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.70674812
88HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.69777669
89TP53_16413492_ChIP-PET_HCT116_Human0.69759221
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.69756852
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.69583394
92* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.69390872
93* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.68634521
94* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.67932601
95STAT3_18555785_Chip-Seq_ESCs_Mouse0.67757692
96GATA1_26923725_Chip-Seq_HPCs_Mouse0.67525319
97* SRF_21415370_ChIP-Seq_HL-1_Mouse0.67383888
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.67293977
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.67293977
100TAF15_26573619_Chip-Seq_HEK293_Human0.66948413
101LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.66548514
102CMYC_18555785_Chip-Seq_ESCs_Mouse0.65377776
103CREB1_15753290_ChIP-ChIP_HEK293T_Human0.62942235
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.62678248
105ER_23166858_ChIP-Seq_MCF-7_Human0.62162287
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.62091279
107CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.62010937
108POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.61305738
109POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.61222172
110* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.60918929
111P53_22387025_ChIP-Seq_ESCs_Mouse0.60526799
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.60312328
113* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.59964129
114* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.59649480
115ZFP57_27257070_Chip-Seq_ESCs_Mouse0.59072997
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.59037742
117XRN2_22483619_ChIP-Seq_HELA_Human0.58386697
118ETS1_22383799_ChIP-Seq_G1ME_Mouse0.58206482
119ELF1_17652178_ChIP-ChIP_JURKAT_Human0.58188149
120MAF_26560356_Chip-Seq_TH1_Human0.57989494
121YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.57954986
122YY1_21170310_ChIP-Seq_MESCs_Mouse0.57464173
123* MYB_26560356_Chip-Seq_TH1_Human0.57050875
124MYC_18555785_ChIP-Seq_MESCs_Mouse0.56975377
125NMYC_18555785_Chip-Seq_ESCs_Mouse0.56773866
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.56419040
127P300_18555785_Chip-Seq_ESCs_Mouse0.55579835
128SOX9_26525672_Chip-Seq_HEART_Mouse0.55308773
129SOX2_18555785_Chip-Seq_ESCs_Mouse0.55262362
130TBL1_22424771_ChIP-Seq_293T_Human0.54371748
131TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.54369458
132KDM5A_27292631_Chip-Seq_BREAST_Human0.53760952
133* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.52942725
134SALL4_22934838_ChIP-ChIP_CD34+_Human0.52485364
135AR_21572438_ChIP-Seq_LNCaP_Human0.52019797
136ESRRB_18555785_Chip-Seq_ESCs_Mouse0.51763970
137SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.51574951
138GBX2_23144817_ChIP-Seq_PC3_Human0.50915072
139MYB_26560356_Chip-Seq_TH2_Human0.50853223
140OCT4_21477851_ChIP-Seq_ESCs_Mouse0.50803276
141NR3C1_21868756_ChIP-Seq_MCF10A_Human0.50524013
142FOXP3_21729870_ChIP-Seq_TREG_Human0.50468846
143* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.50349984
144BRD4_27068464_Chip-Seq_AML-cells_Mouse0.50347801
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.48855646
146CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.48701353
147STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.46945442
148TTF2_22483619_ChIP-Seq_HELA_Human0.46387219
149* GATA3_27048872_Chip-Seq_THYMUS_Human0.45727166
150NANOG_18555785_ChIP-Seq_MESCs_Mouse0.45717692
151* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.45357773

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005257_abnormal_intraocular_pressure6.12903671
2MP0000566_synostosis4.80816916
3MP0003111_abnormal_nucleus_morphology3.95213388
4MP0010094_abnormal_chromosome_stability3.57962466
5MP0002009_preneoplasia3.56868254
6MP0003693_abnormal_embryo_hatching3.41593296
7MP0001849_ear_inflammation3.10779553
8MP0002166_altered_tumor_susceptibility2.84928517
9MP0002102_abnormal_ear_morphology2.84541696
10MP0003077_abnormal_cell_cycle2.82265079
11MP0003787_abnormal_imprinting2.81156494
12MP0000685_abnormal_immune_system2.79879496
13MP0005671_abnormal_response_to2.79704633
14MP0004185_abnormal_adipocyte_glucose2.76729733
15MP0001346_abnormal_lacrimal_gland2.62804190
16MP0005083_abnormal_biliary_tract2.52725198
17MP0003763_abnormal_thymus_physiology2.50495841
18MP0003121_genomic_imprinting2.47984702
19MP0002163_abnormal_gland_morphology2.45892854
20MP0002254_reproductive_system_inflammat2.43814487
21MP0008057_abnormal_DNA_replication2.34968131
22MP0002006_tumorigenesis2.31036163
23MP0000372_irregular_coat_pigmentation2.30515288
24MP0003786_premature_aging2.18295465
25MP0008877_abnormal_DNA_methylation2.17753227
26MP0006292_abnormal_olfactory_placode2.15681204
27MP0000569_abnormal_digit_pigmentation2.14083795
28MP0010307_abnormal_tumor_latency2.12148960
29MP0001800_abnormal_humoral_immune2.09755053
30MP0008058_abnormal_DNA_repair2.08539984
31MP0003937_abnormal_limbs/digits/tail_de2.08413267
32MP0001661_extended_life_span2.04715659
33MP0002396_abnormal_hematopoietic_system1.99470007
34MP0005451_abnormal_body_composition1.96536603
35MP0001873_stomach_inflammation1.91582083
36MP0002160_abnormal_reproductive_system1.90873947
37MP0003123_paternal_imprinting1.83703424
38MP0005408_hypopigmentation1.74789276
39MP0002697_abnormal_eye_size1.74767280
40MP0003136_yellow_coat_color1.70995858
41MP0000013_abnormal_adipose_tissue1.70256778
42MP0001299_abnormal_eye_distance/1.63804171
43MP0001986_abnormal_taste_sensitivity1.60539540
44MP0008007_abnormal_cellular_replicative1.56782079
45MP0000350_abnormal_cell_proliferation1.55122381
46MP0009046_muscle_twitch1.54377533
47MP0003183_abnormal_peptide_metabolism1.52263322
48MP0001730_embryonic_growth_arrest1.51712682
49MP0005389_reproductive_system_phenotype1.49922109
50MP0002084_abnormal_developmental_patter1.48168682
51MP0005387_immune_system_phenotype1.44003342
52MP0001790_abnormal_immune_system1.44003342
53MP0001835_abnormal_antigen_presentation1.41944991
54MP0005379_endocrine/exocrine_gland_phen1.39727961
55MP0001919_abnormal_reproductive_system1.39380423
56MP0006035_abnormal_mitochondrial_morpho1.39329142
57MP0003941_abnormal_skin_development1.39095530
58MP0009250_abnormal_appendicular_skeleto1.38378770
59MP0006072_abnormal_retinal_apoptosis1.36631613
60MP0004957_abnormal_blastocyst_morpholog1.34245947
61MP0002138_abnormal_hepatobiliary_system1.34101207
62MP0000428_abnormal_craniofacial_morphol1.33813003
63MP0009053_abnormal_anal_canal1.33229363
64MP0002085_abnormal_embryonic_tissue1.32514863
65MP0005310_abnormal_salivary_gland1.31674217
66MP0000383_abnormal_hair_follicle1.30199658
67MP0001672_abnormal_embryogenesis/_devel1.28947068
68MP0005380_embryogenesis_phenotype1.28947068
69MP0000689_abnormal_spleen_morphology1.27867930
70MP0005647_abnormal_sex_gland1.27195419
71MP0000432_abnormal_head_morphology1.27105557
72MP0002723_abnormal_immune_serum1.26161964
73MP0002398_abnormal_bone_marrow1.25779536
74MP0000537_abnormal_urethra_morphology1.23884042
75MP0002452_abnormal_antigen_presenting1.23870147
76MP0005000_abnormal_immune_tolerance1.23335293
77MP0002928_abnormal_bile_duct1.20079710
78MP0005220_abnormal_exocrine_pancreas1.17553819
79MP0005253_abnormal_eye_physiology1.16551214
80MP0002019_abnormal_tumor_incidence1.16509305
81MP0010678_abnormal_skin_adnexa1.16025041
82MP0000003_abnormal_adipose_tissue1.15679559
83MP0003938_abnormal_ear_development1.14988863
84MP0002249_abnormal_larynx_morphology1.12948155
85MP0002722_abnormal_immune_system1.12388324
86MP0003984_embryonic_growth_retardation1.12242679
87MP0003890_abnormal_embryonic-extraembry1.12229992
88MP0002420_abnormal_adaptive_immunity1.11075060
89MP0001764_abnormal_homeostasis1.10911051
90MP0000490_abnormal_crypts_of1.10268520
91MP0000371_diluted_coat_color1.08533747
92MP0002938_white_spotting1.08459019
93MP0003252_abnormal_bile_duct1.08092962
94MP0001819_abnormal_immune_cell1.07444977
95MP0000716_abnormal_immune_system1.06405884
96MP0003950_abnormal_plasma_membrane1.05781039
97MP0002088_abnormal_embryonic_growth/wei1.04210342
98MP0000579_abnormal_nail_morphology1.04076802
99MP0004264_abnormal_extraembryonic_tissu1.04021505
100MP0001286_abnormal_eye_development1.03717876
101MP0002086_abnormal_extraembryonic_tissu1.03592491
102MP0005197_abnormal_uvea_morphology1.03371780
103MP0003868_abnormal_feces_composition1.02854901
104MP0000358_abnormal_cell_content/1.02848829
105MP0000703_abnormal_thymus_morphology0.99530173
106MP0000631_abnormal_neuroendocrine_gland0.99478594
107MP0010234_abnormal_vibrissa_follicle0.99194238
108MP0000427_abnormal_hair_cycle0.98364223
109MP0004147_increased_porphyrin_level0.97351747
110MP0002210_abnormal_sex_determination0.97179816
111MP0004808_abnormal_hematopoietic_stem0.96962444
112MP0001188_hyperpigmentation0.96602480
113MP0000049_abnormal_middle_ear0.96485977
114MP0003705_abnormal_hypodermis_morpholog0.96004134
115MP0001697_abnormal_embryo_size0.94199763
116MP0000015_abnormal_ear_pigmentation0.93913075
117MP0001348_abnormal_lacrimal_gland0.93303359
118MP0008770_decreased_survivor_rate0.92800495
119MP0002277_abnormal_respiratory_mucosa0.92786844
120MP0003755_abnormal_palate_morphology0.92730906
121MP0000733_abnormal_muscle_development0.92301263
122MP0004197_abnormal_fetal_growth/weight/0.90895071
123MP0001293_anophthalmia0.90437223
124MP0002429_abnormal_blood_cell0.89555607
125MP0003656_abnormal_erythrocyte_physiolo0.89207971
126MP0003718_maternal_effect0.87514047
127MP0002233_abnormal_nose_morphology0.87451563
128MP0008872_abnormal_physiological_respon0.86157323
129MP0002109_abnormal_limb_morphology0.85973708
130MP0002111_abnormal_tail_morphology0.84554331
131MP0003385_abnormal_body_wall0.84486890
132MP0005645_abnormal_hypothalamus_physiol0.83534320
133MP0008932_abnormal_embryonic_tissue0.83199363
134MP0005666_abnormal_adipose_tissue0.83021822
135MP0003861_abnormal_nervous_system0.81936343
136MP0002075_abnormal_coat/hair_pigmentati0.81783453
137MP0002114_abnormal_axial_skeleton0.81623163
138MP0005076_abnormal_cell_differentiation0.81179231
139MP0000538_abnormal_urinary_bladder0.80894085
140MP0000462_abnormal_digestive_system0.80267032
141MP0000465_gastrointestinal_hemorrhage0.80237958
142MP0002876_abnormal_thyroid_physiology0.79817006
143MP0003699_abnormal_female_reproductive0.79696985
144MP0008875_abnormal_xenobiotic_pharmacok0.78594540
145MP0003935_abnormal_craniofacial_develop0.78216891
146MP0004134_abnormal_chest_morphology0.77219510
147MP0002136_abnormal_kidney_physiology0.76102814
148MP0003045_fibrosis0.75825477
149MP0002693_abnormal_pancreas_physiology0.75695459
150MP0009672_abnormal_birth_weight0.75439838
151MP0005623_abnormal_meninges_morphology0.75366128
152MP0009697_abnormal_copulation0.74900270
153MP0002095_abnormal_skin_pigmentation0.74616402
154MP0000313_abnormal_cell_death0.74337345
155MP0002080_prenatal_lethality0.72589958
156MP0005365_abnormal_bile_salt0.72495690
157MP0002116_abnormal_craniofacial_bone0.72185146
158MP0004381_abnormal_hair_follicle0.72054439
159MP0004145_abnormal_muscle_electrophysio0.70816579
160MP0010352_gastrointestinal_tract_polyps0.70233026
161MP0005171_absent_coat_pigmentation0.69864781
162MP0001929_abnormal_gametogenesis0.68873313
163MP0001191_abnormal_skin_condition0.68693386
164MP0002092_abnormal_eye_morphology0.68137693
165MP0009703_decreased_birth_body0.67973949
166MP0000653_abnormal_sex_gland0.67295506
167MP0001119_abnormal_female_reproductive0.66933489
168MP0001145_abnormal_male_reproductive0.65908569

Predicted human phenotypes

RankGene SetZ-score
1IgA deficiency (HP:0002720)5.50362984
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.42639586
3Chromsome breakage (HP:0040012)5.31825994
4Impulsivity (HP:0100710)4.67237931
5IgM deficiency (HP:0002850)4.28345548
6Ectopic kidney (HP:0000086)4.18241418
7Squamous cell carcinoma (HP:0002860)3.98931259
8Abnormality of the intervertebral disk (HP:0005108)3.98424503
9Small epiphyses (HP:0010585)3.92710760
10Prostate neoplasm (HP:0100787)3.58290740
11Oral leukoplakia (HP:0002745)3.56882143
12IgG deficiency (HP:0004315)3.52790119
13Abnormality of DNA repair (HP:0003254)3.26442362
14Hypoplasia of the pons (HP:0012110)3.23696414
15Abnormality of the pons (HP:0007361)3.22459667
16Hypoplasia of the capital femoral epiphysis (HP:0003090)3.19519348
17Large eyes (HP:0001090)3.17723489
18Abnormality of chromosome stability (HP:0003220)3.17320614
19Chronic diarrhea (HP:0002028)3.14253346
20Abnormality of the fingertips (HP:0001211)3.11282687
21Ulnar bowing (HP:0003031)3.09150493
22Abnormality of the labia minora (HP:0012880)3.08668029
23Recurrent bronchitis (HP:0002837)3.06550635
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.99209359
25Recurrent sinusitis (HP:0011108)2.98536284
26Abnormality of the preputium (HP:0100587)2.93887294
27Birth length less than 3rd percentile (HP:0003561)2.90525082
28Lip pit (HP:0100267)2.88920416
29Gastrointestinal stroma tumor (HP:0100723)2.88489531
30Osteomalacia (HP:0002749)2.87386660
31Vertebral arch anomaly (HP:0008438)2.85886564
32Dry hair (HP:0011359)2.85269441
33Meckel diverticulum (HP:0002245)2.83176798
34Volvulus (HP:0002580)2.78354870
35Poikilocytosis (HP:0004447)2.76169811
36Duplicated collecting system (HP:0000081)2.70704386
37Microtia (HP:0008551)2.66850706
38Arthropathy (HP:0003040)2.62141717
39Abnormality of the ileum (HP:0001549)2.60350064
40Basal cell carcinoma (HP:0002671)2.56966603
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.56663555
42Abnormality of alanine metabolism (HP:0010916)2.56663555
43Hyperalaninemia (HP:0003348)2.56663555
44Absent thumb (HP:0009777)2.55271510
45Patellar aplasia (HP:0006443)2.55205528
46Hypochromic microcytic anemia (HP:0004840)2.53715326
47Pendular nystagmus (HP:0012043)2.52600715
48Anomalous pulmonary venous return (HP:0010772)2.49730185
49Lymphopenia (HP:0001888)2.48694993
50Clubbing of toes (HP:0100760)2.48166027
51Tibial bowing (HP:0002982)2.45262406
52Prominent nose (HP:0000448)2.44901923
53Acanthocytosis (HP:0001927)2.43625663
54Abnormality of cells of the lymphoid lineage (HP:0012140)2.37949724
55Abnormality of the renal collecting system (HP:0004742)2.35706189
56Sparse lateral eyebrow (HP:0005338)2.35698456
57Absent epiphyses (HP:0010577)2.35487005
58Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.35487005
59Abnormality of the pulmonary veins (HP:0011718)2.34213914
60Colitis (HP:0002583)2.33653605
61Mitral stenosis (HP:0001718)2.33208279
62Facial hemangioma (HP:0000329)2.33126785
63Abnormal albumin level (HP:0012116)2.33100343
64Hypoalbuminemia (HP:0003073)2.33100343
65Hepatocellular necrosis (HP:0001404)2.32435922
66Aplasia cutis congenita (HP:0001057)2.31572969
673-Methylglutaconic aciduria (HP:0003535)2.31058771
68Cerebellar dysplasia (HP:0007033)2.28697513
69Astrocytoma (HP:0009592)2.27536758
70Abnormality of the astrocytes (HP:0100707)2.27536758
71Aplasia/Hypoplasia of the patella (HP:0006498)2.26008226
72Carpal bone hypoplasia (HP:0001498)2.25909489
73Ependymoma (HP:0002888)2.24159205
74Sloping forehead (HP:0000340)2.22633955
75Limited hip movement (HP:0008800)2.22229232
76Conical tooth (HP:0000698)2.21722241
77Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.21267636
78Midline defect of the nose (HP:0004122)2.21019981
79Abnormality of the carotid arteries (HP:0005344)2.20587628
80Abnormality of T cell physiology (HP:0011840)2.20166839
81Abnormality of the proximal phalanges of the hand (HP:0009834)2.19894513
82Agammaglobulinemia (HP:0004432)2.17499611
83Neoplasm of the oral cavity (HP:0100649)2.16893039
84Short phalanx of the thumb (HP:0009660)2.15104751
85Small intestinal stenosis (HP:0012848)2.13205803
86Duodenal stenosis (HP:0100867)2.13205803
87Long eyelashes (HP:0000527)2.11076669
88Increased serum lactate (HP:0002151)2.10348318
89Flared metaphyses (HP:0003015)2.08794597
90Chronic hepatic failure (HP:0100626)2.08726133
91Papillary thyroid carcinoma (HP:0002895)2.08502054
92Abnormality of the parietal bone (HP:0002696)2.07717160
93Abnormality of the prostate (HP:0008775)2.06372747
94Hemivertebrae (HP:0002937)2.06313562
95Thyroiditis (HP:0100646)2.05965785
96Chin dimple (HP:0010751)2.05114363
97Abnormality of incisor morphology (HP:0011063)2.03399762
98Shawl scrotum (HP:0000049)2.03301884
99Myelomeningocele (HP:0002475)2.02620251
100Spina bifida occulta (HP:0003298)2.02331134
101Colon cancer (HP:0003003)2.00383145
102Type II lissencephaly (HP:0007260)2.00308437
103Lymphoma (HP:0002665)1.99688154
104Entropion (HP:0000621)1.99526807
105Abnormality of the renal cortex (HP:0011035)1.99076570
106Limited elbow extension (HP:0001377)1.97438996
107Abnormality of the phalanges of the hallux (HP:0010057)1.96121244
108Aortic regurgitation (HP:0001659)1.95470613
109Hepatic necrosis (HP:0002605)1.94267719
110Abnormality of the nasal septum (HP:0000419)1.93276371
111Ureteral duplication (HP:0000073)1.93195007
112Genu recurvatum (HP:0002816)1.91792222
113Abnormality of the antihelix (HP:0009738)1.91018205
114Flattened epiphyses (HP:0003071)1.90481629
115Capillary hemangiomas (HP:0005306)1.90480590
116Sparse scalp hair (HP:0002209)1.90009600
117Hypoplastic iliac wings (HP:0002866)1.89224086
118Anal stenosis (HP:0002025)1.89032678
119Abnormality of T cells (HP:0002843)1.88451667
120Leukopenia (HP:0001882)1.87086333
121Myelodysplasia (HP:0002863)1.84700283
122Microvesicular hepatic steatosis (HP:0001414)1.84661706
123Oligodontia (HP:0000677)1.84480722
124Vertebral fusion (HP:0002948)1.83414008
125Abnormality of the duodenum (HP:0002246)1.83087078
126Abnormality of pyrimidine metabolism (HP:0004353)1.82790306
127Subcapsular cataract (HP:0000523)1.82647113
128Barrel-shaped chest (HP:0001552)1.81895977
129Lipid accumulation in hepatocytes (HP:0006561)1.81385930
130Increased CSF lactate (HP:0002490)1.81326732
131Tubular atrophy (HP:0000092)1.80898868
132Autoimmune hemolytic anemia (HP:0001890)1.78943206
133Fibular aplasia (HP:0002990)1.78701190
134Gaze-evoked nystagmus (HP:0000640)1.78319586
135Short 4th metacarpal (HP:0010044)1.78297483
136Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.78297483
137Ridged nail (HP:0001807)1.77829756
138Abnormal number of erythroid precursors (HP:0012131)1.77657257
139Anal atresia (HP:0002023)1.77438313
140Breast aplasia (HP:0100783)1.77314453
141Heterotopia (HP:0002282)1.76679079
142Absent radius (HP:0003974)1.76359127
143Glioma (HP:0009733)1.76120141
144Lissencephaly (HP:0001339)1.74734968
145Tongue fasciculations (HP:0001308)1.74300980
146Mitochondrial inheritance (HP:0001427)1.74191530
147Bronchitis (HP:0012387)1.73666057
148Hypergonadotropic hypogonadism (HP:0000815)1.72797389
149Oligodactyly (hands) (HP:0001180)1.72406391
150Premature graying of hair (HP:0002216)1.72308743
151Microretrognathia (HP:0000308)1.72174617
152Renal cortical cysts (HP:0000803)1.71595292
153Arteriovenous malformation (HP:0100026)1.71564315
154Aseptic necrosis (HP:0010885)1.70870018
155Poikiloderma (HP:0001029)1.70119704
156Complete atrioventricular canal defect (HP:0001674)1.70105930
157Hypoplasia of the uterus (HP:0000013)1.70026388
158Short thumb (HP:0009778)1.68755537
159Pancreatic cysts (HP:0001737)1.68533729
160Adrenal hypoplasia (HP:0000835)1.68491772
161Concave nail (HP:0001598)1.68137526
162Subacute progressive viral hepatitis (HP:0006572)1.67879411
163Neoplasm of the heart (HP:0100544)1.67551009
164Cellular immunodeficiency (HP:0005374)1.66610968
165Aplasia/Hypoplasia of the breasts (HP:0010311)1.66219620
166Partial agenesis of the corpus callosum (HP:0001338)1.66152180
167Bone marrow hypocellularity (HP:0005528)1.65461352
168Sensory axonal neuropathy (HP:0003390)1.65171759
169Aplasia/Hypoplasia of the sternum (HP:0006714)1.64473892
170Smooth philtrum (HP:0000319)1.64458582
171Medulloblastoma (HP:0002885)1.63900819
172Hypopigmentation of the fundus (HP:0007894)1.63875999
173Cafe-au-lait spot (HP:0000957)1.62453587
174Aplasia involving forearm bones (HP:0009822)1.61033216

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK17.38501032
2ZAK5.32478613
3CDK124.87461803
4CDC73.94928366
5LATS13.75305447
6CDK82.98243753
7VRK12.87096455
8NEK22.43740466
9RPS6KA52.36124935
10CHEK22.35593870
11STK42.09763193
12SRPK12.04360402
13STK38L1.94728565
14LATS21.80666298
15CAMK1D1.76926482
16STK31.66750200
17CDK91.65598080
18FRK1.47133324
19AURKB1.46414715
20NUAK11.46016417
21ERBB41.40742365
22CDK71.32256345
23MAP4K21.30977499
24PKN11.30521871
25PIM21.23245594
26TTK1.22502572
27PIM11.11142726
28MKNK21.09371526
29CAMK1G1.08718605
30TAF11.05040063
31PLK41.03797536
32DMPK1.00320472
33AKT20.95691061
34INSRR0.95001975
35CHEK10.94776738
36EIF2AK20.92710289
37MELK0.92679460
38ATR0.92337982
39ATM0.92289535
40IKBKB0.90550171
41BRSK20.89467973
42NEK10.82948891
43EIF2AK30.80153707
44SMG10.79680857
45PLK10.78510568
46BRD40.76071826
47CDK20.75956040
48BCKDK0.75346014
49SIK20.73313604
50EPHA30.73088095
51BRSK10.71571276
52MAP3K60.71404565
53NTRK30.69193502
54MAPK110.67555942
55MARK30.66673896
56CSNK1G10.65353488
57ACVR1B0.65326605
58MTOR0.65201815
59MAP2K70.64725284
60CSNK1A1L0.64408272
61CDK10.63989717
62MAP3K40.63934119
63OXSR10.63085883
64PAK60.62397010
65EEF2K0.62311597
66FGR0.62262635
67TXK0.62158704
68MAP4K10.61343348
69CSNK1G30.60738278
70TAOK10.60557900
71PBK0.59980029
72DYRK30.59129570
73BMPR1B0.58698475
74STK380.58203308
75MAP3K80.58070726
76MAPK140.57935295
77ADRBK20.57928629
78CAMKK20.57927167
79STK390.57889965
80RAF10.57173921
81WEE10.56993693
82PDK20.56850461
83STK160.56290124
84GRK10.55260682
85SYK0.54920775
86MAPK100.54334206
87PLK30.54203438
88CSNK1E0.54122382
89CSNK1D0.53824936
90CDK40.53361120
91AURKA0.53200102
92TAOK30.51446503
93MAPKAPK50.49810688
94STK100.49565506
95AKT30.48136883
96PRKCI0.47014200
97MKNK10.45906936
98BTK0.45321957
99CCNB10.45281085
100PAK20.44989901
101PRKAA10.44882860
102MST40.44852326
103NEK90.44741028
104CDK30.42392693
105IRAK40.42077082
106MARK20.41897372
107IKBKE0.41062743
108ITK0.38525521
109PRKD20.38392729
110PRKAA20.37168741
111BUB10.36918938
112GSK3B0.36487040
113SCYL20.34526462
114CHUK0.32074389
115RPS6KA30.30856892
116DAPK30.30715102
117RPS6KB20.30659465
118SGK10.30623088
119CDK60.30230793
120NTRK20.30013354
121MAPKAPK30.30000611
122AKT10.29428781
123CSNK1G20.29145835
124PRKDC0.29022094
125LYN0.27363348
126TEC0.27034600
127PRKACB0.26940258
128EIF2AK10.26850364
129EPHA20.26399383
130ICK0.25550998
131ROCK10.25376149
132STK110.25288297
133NLK0.25228034
134MAP2K20.25137973
135CAMK40.23995535
136MAPK130.23933771
137BLK0.23691362
138TRPM70.22263259
139RPS6KA60.22011542
140CSNK2A20.20820633
141PDGFRB0.20604165
142FER0.20292086
143CASK0.20290416
144WNK40.19924116
145KDR0.19470668
146TNK20.19379940
147EPHB20.19277252
148STK240.18828798
149RPS6KA40.18355199
150PRKCQ0.17609466
151KSR10.16511062
152MAPK120.14638459
153JAK20.12998428
154RPS6KA10.12353197
155HIPK20.12199054
156SGK20.11327957
157VRK20.11311586
158RPS6KC10.11047559
159RPS6KL10.11047559
160TIE10.09922595

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050345.88958661
2Basal transcription factors_Homo sapiens_hsa030222.89295827
3* Viral carcinogenesis_Homo sapiens_hsa052032.85652036
4Fanconi anemia pathway_Homo sapiens_hsa034602.16922975
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02077700
6* Systemic lupus erythematosus_Homo sapiens_hsa0532210.7155188
7Transcriptional misregulation in cancer_Homo sapiens_hsa052021.99327296
8Cell cycle_Homo sapiens_hsa041101.95947662
9Non-homologous end-joining_Homo sapiens_hsa034501.92784125
10Mismatch repair_Homo sapiens_hsa034301.74463700
11Homologous recombination_Homo sapiens_hsa034401.63390683
12DNA replication_Homo sapiens_hsa030301.53298454
13Spliceosome_Homo sapiens_hsa030401.40741616
14One carbon pool by folate_Homo sapiens_hsa006701.37306483
15RNA transport_Homo sapiens_hsa030131.35309343
16MicroRNAs in cancer_Homo sapiens_hsa052061.31226031
17Allograft rejection_Homo sapiens_hsa053301.24725151
18mRNA surveillance pathway_Homo sapiens_hsa030151.15092414
19p53 signaling pathway_Homo sapiens_hsa041151.14917453
20Graft-versus-host disease_Homo sapiens_hsa053321.08578023
21Small cell lung cancer_Homo sapiens_hsa052221.04060590
22Sulfur relay system_Homo sapiens_hsa041221.02491287
23Lysine degradation_Homo sapiens_hsa003101.01494100
24Melanoma_Homo sapiens_hsa052181.01444336
25Asthma_Homo sapiens_hsa053101.00214729
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93239198
27Type I diabetes mellitus_Homo sapiens_hsa049400.92626017
28Pancreatic cancer_Homo sapiens_hsa052120.91382728
29Herpes simplex infection_Homo sapiens_hsa051680.91092582
30Nucleotide excision repair_Homo sapiens_hsa034200.89213648
31RNA degradation_Homo sapiens_hsa030180.87672329
32Non-small cell lung cancer_Homo sapiens_hsa052230.86348003
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85980488
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81549662
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77054485
36Chronic myeloid leukemia_Homo sapiens_hsa052200.71952481
37Prostate cancer_Homo sapiens_hsa052150.70372842
38RNA polymerase_Homo sapiens_hsa030200.69970526
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68474951
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67017979
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65723065
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65559440
43Colorectal cancer_Homo sapiens_hsa052100.64182362
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62176036
45Glioma_Homo sapiens_hsa052140.60703583
46Sulfur metabolism_Homo sapiens_hsa009200.60508729
47mTOR signaling pathway_Homo sapiens_hsa041500.59680195
48Ribosome_Homo sapiens_hsa030100.57347956
49HTLV-I infection_Homo sapiens_hsa051660.55996145
50Base excision repair_Homo sapiens_hsa034100.55868043
51Oxidative phosphorylation_Homo sapiens_hsa001900.55103330
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.54995207
53Vitamin digestion and absorption_Homo sapiens_hsa049770.53446510
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53212315
55Type II diabetes mellitus_Homo sapiens_hsa049300.51884783
56Nicotine addiction_Homo sapiens_hsa050330.51739586
57Prolactin signaling pathway_Homo sapiens_hsa049170.51478391
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50356349
59Antigen processing and presentation_Homo sapiens_hsa046120.49450725
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49018805
61Viral myocarditis_Homo sapiens_hsa054160.47104550
62Hepatitis B_Homo sapiens_hsa051610.45937544
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45742228
64Fatty acid biosynthesis_Homo sapiens_hsa000610.45481313
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44260335
66Basal cell carcinoma_Homo sapiens_hsa052170.44023188
67Tryptophan metabolism_Homo sapiens_hsa003800.43821225
68Autoimmune thyroid disease_Homo sapiens_hsa053200.43018143
69FoxO signaling pathway_Homo sapiens_hsa040680.42886271
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.42231490
71Nitrogen metabolism_Homo sapiens_hsa009100.41977043
72B cell receptor signaling pathway_Homo sapiens_hsa046620.40423901
73Adherens junction_Homo sapiens_hsa045200.40328153
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40050965
75TGF-beta signaling pathway_Homo sapiens_hsa043500.39054766
76Huntingtons disease_Homo sapiens_hsa050160.37709641
77Pyrimidine metabolism_Homo sapiens_hsa002400.37389618
78Bladder cancer_Homo sapiens_hsa052190.36528213
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35727580
80ABC transporters_Homo sapiens_hsa020100.35466803
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35281054
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35138749
83Endometrial cancer_Homo sapiens_hsa052130.35115083
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34105031
85Renal cell carcinoma_Homo sapiens_hsa052110.33560380
86Wnt signaling pathway_Homo sapiens_hsa043100.33232378
87Measles_Homo sapiens_hsa051620.32804310
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32712702
89Hematopoietic cell lineage_Homo sapiens_hsa046400.32339938
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31402665
91Inositol phosphate metabolism_Homo sapiens_hsa005620.31201795
92Hippo signaling pathway_Homo sapiens_hsa043900.30783785
93ErbB signaling pathway_Homo sapiens_hsa040120.30441058
94Pathways in cancer_Homo sapiens_hsa052000.30326854
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30079731
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.29792496
97Parkinsons disease_Homo sapiens_hsa050120.29595308
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28505202
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28423738
100Renin-angiotensin system_Homo sapiens_hsa046140.27943232
101Peroxisome_Homo sapiens_hsa041460.27625852
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26912187
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26704051
104Linoleic acid metabolism_Homo sapiens_hsa005910.26164888
105cAMP signaling pathway_Homo sapiens_hsa040240.24774490
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23488297
107Vitamin B6 metabolism_Homo sapiens_hsa007500.22516168
108Primary immunodeficiency_Homo sapiens_hsa053400.22074674
109Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.22054549
110TNF signaling pathway_Homo sapiens_hsa046680.21476979
111Ras signaling pathway_Homo sapiens_hsa040140.21381045
112Notch signaling pathway_Homo sapiens_hsa043300.21340840
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21288916
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20411806
115Epstein-Barr virus infection_Homo sapiens_hsa051690.19945871
116Influenza A_Homo sapiens_hsa051640.19669527
117Alzheimers disease_Homo sapiens_hsa050100.19391922
118Purine metabolism_Homo sapiens_hsa002300.19047198
119Oocyte meiosis_Homo sapiens_hsa041140.18849070
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.18818466
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18813134
122Apoptosis_Homo sapiens_hsa042100.18273901
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.17472836
124Fructose and mannose metabolism_Homo sapiens_hsa000510.17377984
125Choline metabolism in cancer_Homo sapiens_hsa052310.16886111
126HIF-1 signaling pathway_Homo sapiens_hsa040660.16769881
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.16766512
128Ether lipid metabolism_Homo sapiens_hsa005650.16694252
129Axon guidance_Homo sapiens_hsa043600.16305264
130Taste transduction_Homo sapiens_hsa047420.15953756
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.15919756
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.15474719
133Caffeine metabolism_Homo sapiens_hsa002320.14638779
134Selenocompound metabolism_Homo sapiens_hsa004500.14374158
135MAPK signaling pathway_Homo sapiens_hsa040100.14265184
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13770753
137Steroid hormone biosynthesis_Homo sapiens_hsa001400.13757241
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13451180
139Proteoglycans in cancer_Homo sapiens_hsa052050.13447371
140Rheumatoid arthritis_Homo sapiens_hsa053230.12954586
141Rap1 signaling pathway_Homo sapiens_hsa040150.12779674
142Metabolic pathways_Homo sapiens_hsa011000.12779536
143N-Glycan biosynthesis_Homo sapiens_hsa005100.12020919
144Phototransduction_Homo sapiens_hsa047440.11625257
145T cell receptor signaling pathway_Homo sapiens_hsa046600.11510540
146Ovarian steroidogenesis_Homo sapiens_hsa049130.10877563
147Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.09232221
148Biosynthesis of amino acids_Homo sapiens_hsa012300.08244317
149Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.06660164
150Hedgehog signaling pathway_Homo sapiens_hsa043400.06601735
151Cyanoamino acid metabolism_Homo sapiens_hsa004600.05651395

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