HIVEP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor belonging to the ZAS family, members of which are large proteins that contain a ZAS domain - a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specifically to the DNA sequence motif, GGGACTTTCC, found in the enhancer elements of several viral promoters, including human immunodeficiency virus (HIV), and to related sequences found in the enhancer elements of a number of cellular promoters. This protein binds to this sequence motif, suggesting a role in the transcriptional regulation of both viral and cellular genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NIK/NF-kappaB signaling (GO:0038061)4.70617232
2growth hormone receptor signaling pathway (GO:0060396)4.47107271
3cytoplasmic mRNA processing body assembly (GO:0033962)4.36608071
4regulation of interleukin-12 biosynthetic process (GO:0045075)4.05137590
5regulation of B cell receptor signaling pathway (GO:0050855)3.79402126
6cellular response to growth hormone stimulus (GO:0071378)3.74937614
7cellular response to ethanol (GO:0071361)3.53425291
8positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.47244052
9CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.37144630
10phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.35207904
11histone H3-K4 trimethylation (GO:0080182)3.27914672
12JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.26392704
13interkinetic nuclear migration (GO:0022027)3.09001093
14protein K11-linked deubiquitination (GO:0035871)3.08649752
15protein K48-linked deubiquitination (GO:0071108)3.08402452
16antigen processing and presentation of endogenous antigen (GO:0019883)3.08112682
17establishment of protein localization to Golgi (GO:0072600)3.04221832
18positive regulation of gamma-delta T cell activation (GO:0046645)3.02739938
19negative regulation of T cell mediated immunity (GO:0002710)3.02056427
20negative regulation of interleukin-12 production (GO:0032695)3.01424988
21monoubiquitinated protein deubiquitination (GO:0035520)2.99387882
22germinal center formation (GO:0002467)2.92152891
23tolerance induction (GO:0002507)2.90710019
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.90090166
25B cell receptor signaling pathway (GO:0050853)2.83589721
26interferon-gamma production (GO:0032609)2.82679066
27regulation of ARF protein signal transduction (GO:0032012)2.78227367
28positive regulation of natural killer cell differentiation (GO:0032825)2.76350126
29myeloid dendritic cell differentiation (GO:0043011)2.75213422
30regulation of vitamin D biosynthetic process (GO:0060556)2.74614530
31histone H3-K36 demethylation (GO:0070544)2.72420459
32negative regulation of histone methylation (GO:0031061)2.72075539
33negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.71607900
34negative regulation of cell killing (GO:0031342)2.71607900
35peptidyl-lysine methylation (GO:0018022)2.69642835
36protein targeting to Golgi (GO:0000042)2.69627358
37positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.67472080
38antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.67394132
39antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.67394132
40negative thymic T cell selection (GO:0045060)2.66270755
41regulation of T-helper 1 cell differentiation (GO:0045625)2.63946236
42positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.61443109
43regulation of protein polyubiquitination (GO:1902914)2.61367788
44T cell lineage commitment (GO:0002360)2.60073495
45interleukin-6-mediated signaling pathway (GO:0070102)2.59156432
46histone H3-K4 methylation (GO:0051568)2.58095997
47regulation of interferon-alpha production (GO:0032647)2.57102209
48oocyte development (GO:0048599)2.57042899
49cellular response to type I interferon (GO:0071357)2.56633014
50type I interferon signaling pathway (GO:0060337)2.56633014
51regulation of RIG-I signaling pathway (GO:0039535)2.53134872
52protein demethylation (GO:0006482)2.53127547
53protein dealkylation (GO:0008214)2.53127547
54positive regulation of interferon-alpha production (GO:0032727)2.51177800
55response to muramyl dipeptide (GO:0032495)2.50685841
56negative T cell selection (GO:0043383)2.48955955
57regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.47275365
58corticosteroid receptor signaling pathway (GO:0031958)2.46198670
59thymic T cell selection (GO:0045061)2.46000063
60response to protozoan (GO:0001562)2.45881308
61defense response to protozoan (GO:0042832)2.44952823
62T-helper cell differentiation (GO:0042093)2.44454342
63CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.44454342
64regulation of T-helper cell differentiation (GO:0045622)2.44417762
65regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.43966262
66regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.42147900
67interferon-gamma-mediated signaling pathway (GO:0060333)2.42015841
68NLS-bearing protein import into nucleus (GO:0006607)2.41209559
69T-helper 1 type immune response (GO:0042088)2.40118510
70positive regulation of interferon-beta production (GO:0032728)2.39089276
71regulation of B cell proliferation (GO:0030888)2.38852752
72histone H3-K9 modification (GO:0061647)2.38624584
73regulation of alkaline phosphatase activity (GO:0010692)2.38069979
74B cell homeostasis (GO:0001782)2.37735049
75positive regulation of histone deacetylation (GO:0031065)2.37490710
76positive T cell selection (GO:0043368)2.37046654
77negative regulation of B cell proliferation (GO:0030889)2.36087363
78positive regulation of defense response to virus by host (GO:0002230)2.35933258
79myeloid dendritic cell activation (GO:0001773)2.35555780
80positive thymic T cell selection (GO:0045059)2.35461006
81T cell selection (GO:0045058)2.33743472
82regulation of gamma-delta T cell activation (GO:0046643)2.33586344
83regulation of gamma-delta T cell differentiation (GO:0045586)2.33299004
84regulation of MHC class I biosynthetic process (GO:0045343)2.32959146
85regulation of alpha-beta T cell proliferation (GO:0046640)2.32695793
86regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.31977454
87stress granule assembly (GO:0034063)2.31722412
88regulation of interferon-beta production (GO:0032648)2.31159100
89positive regulation of heat generation (GO:0031652)2.30991206
90detection of molecule of bacterial origin (GO:0032490)2.30582473
91cellular response to interleukin-15 (GO:0071350)2.30390780
92negative regulation of NF-kappaB import into nucleus (GO:0042347)2.29491668
93regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.29152762
94positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.26663047
95positive regulation of interleukin-12 production (GO:0032735)2.23721838
96natural killer cell mediated immunity (GO:0002228)2.23002587
97natural killer cell mediated cytotoxicity (GO:0042267)2.23002587
98regulation of transforming growth factor beta2 production (GO:0032909)2.22684183
99negative regulation of translation, ncRNA-mediated (GO:0040033)2.20910747
100regulation of translation, ncRNA-mediated (GO:0045974)2.20910747
101negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.20910747
102retrograde transport, vesicle recycling within Golgi (GO:0000301)2.19416794
103JAK-STAT cascade (GO:0007259)2.19158239
104peptidyl-lysine trimethylation (GO:0018023)2.18810179
105regulation of interferon-beta biosynthetic process (GO:0045357)2.16882964
106regulation of dendritic cell antigen processing and presentation (GO:0002604)2.14963669
107regulation of hypersensitivity (GO:0002883)2.13764570
108regulation of integrin activation (GO:0033623)2.13677751
109positive regulation of p38MAPK cascade (GO:1900745)2.13216536
110histone lysine demethylation (GO:0070076)2.12801933
111sodium ion export (GO:0071436)2.12775989
112hepatocyte apoptotic process (GO:0097284)2.12324768
113regulation of NFAT protein import into nucleus (GO:0051532)2.12168799
114regulation of necroptotic process (GO:0060544)2.11617593
115natural killer cell differentiation (GO:0001779)2.11261614
116regulation of T cell tolerance induction (GO:0002664)2.10888524
117regulation of clathrin-mediated endocytosis (GO:2000369)2.10091722
118fibroblast migration (GO:0010761)2.10005097
119regulation of chemokine-mediated signaling pathway (GO:0070099)2.09353075
120neutrophil activation (GO:0042119)2.08411422
121response to interleukin-15 (GO:0070672)2.05954868
122positive regulation of humoral immune response (GO:0002922)2.04360108
123regulation of interleukin-12 production (GO:0032655)2.04162269
124regulation of type I interferon-mediated signaling pathway (GO:0060338)2.03501729
125positive regulation of CREB transcription factor activity (GO:0032793)2.02986860
126granulocyte activation (GO:0036230)2.02459891
127dendritic cell differentiation (GO:0097028)2.01652121
128peptidyl-threonine phosphorylation (GO:0018107)2.01610288
129macrophage activation involved in immune response (GO:0002281)2.00418234
130positive regulation of T cell cytokine production (GO:0002726)1.99624916
131coronary vasculature morphogenesis (GO:0060977)1.99530009
132modulation by organism of defense response of other organism involved in symbiotic interaction (GO:01.98570939
133positive regulation by organism of defense response of other organism involved in symbiotic interact1.98570939
134modulation by symbiont of host immune response (GO:0052553)1.98570939
135positive regulation by symbiont of host defense response (GO:0052509)1.98570939
136modulation by symbiont of host defense response (GO:0052031)1.98570939
137modulation by organism of immune response of other organism involved in symbiotic interaction (GO:001.98570939
138T cell differentiation involved in immune response (GO:0002292)1.98464516
139alpha-beta T cell differentiation involved in immune response (GO:0002293)1.98464516
140alpha-beta T cell activation involved in immune response (GO:0002287)1.98464516
141positive regulation of interleukin-2 production (GO:0032743)1.98141184
142positive regulation of B cell differentiation (GO:0045579)1.97967414
143glomerular visceral epithelial cell development (GO:0072015)1.97747796
144regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.97321644
145I-kappaB phosphorylation (GO:0007252)1.96214226
146CD4-positive, alpha-beta T cell differentiation (GO:0043367)1.96138594
147tyrosine phosphorylation of STAT protein (GO:0007260)1.96098263
148interferon-gamma secretion (GO:0072643)1.95726270
149histone lysine methylation (GO:0034968)1.95391143
150histone H3-K9 demethylation (GO:0033169)1.94916983
151peptidyl-threonine modification (GO:0018210)1.94441675
152histone demethylation (GO:0016577)1.92991244
153response to type I interferon (GO:0034340)1.92783055
154regulation of p38MAPK cascade (GO:1900744)1.90788590
155T cell migration (GO:0072678)1.89771285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.42332171
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.37603493
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.13561440
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.68392195
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.64996272
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.53524956
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.34281253
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.21367033
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.00420798
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99460927
11RUNX_20019798_ChIP-Seq_JUKART_Human1.99097712
12NOTCH1_21737748_ChIP-Seq_TLL_Human1.97063389
13EZH2_22144423_ChIP-Seq_EOC_Human1.90853637
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87750388
15* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.85929266
16* TCF7_22412390_ChIP-Seq_EML_Mouse1.85778697
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84214197
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.80114740
19* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.61880495
20* KDM2B_26808549_Chip-Seq_DND41_Human1.59565572
21KDM2B_26808549_Chip-Seq_K562_Human1.58398712
22* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56098808
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.52900997
24* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52646888
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.51282707
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51121863
27MYC_22102868_ChIP-Seq_BL_Human1.50545581
28* KDM2B_26808549_Chip-Seq_JURKAT_Human1.47920719
29AHR_22903824_ChIP-Seq_MCF-7_Human1.46106521
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44412191
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.41947307
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.40821742
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39104134
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35493526
35* VDR_24787735_ChIP-Seq_THP-1_Human1.35320502
36* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34502080
37FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33924208
38STAT3_23295773_ChIP-Seq_U87_Human1.32681864
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32124941
40* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31683941
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.31251385
42* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31222649
43* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.31059490
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29246566
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.27392022
46* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25996782
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25776043
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25137158
49CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25012505
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24484858
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24013150
52PRDM14_20953172_ChIP-Seq_ESCs_Human1.22771618
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.22513132
54GBX2_23144817_ChIP-Seq_PC3_Human1.21896067
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21406480
56* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21329384
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.21048451
58DROSHA_22980978_ChIP-Seq_HELA_Human1.20927699
59GATA1_22025678_ChIP-Seq_K562_Human1.20712868
60AR_21572438_ChIP-Seq_LNCaP_Human1.19367959
61GATA3_26560356_Chip-Seq_TH2_Human1.17904806
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17178789
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16612259
64* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15475553
65MAF_26560356_Chip-Seq_TH1_Human1.15273940
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14775201
67RXR_22108803_ChIP-Seq_LS180_Human1.13744619
68* SMAD4_21799915_ChIP-Seq_A2780_Human1.13455704
69SPI1_23127762_ChIP-Seq_K562_Human1.12837712
70TCF4_23295773_ChIP-Seq_U87_Human1.12522692
71FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.12374092
72MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11541910
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10964772
74* GATA2_21666600_ChIP-Seq_HMVEC_Human1.09939322
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09935193
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09682865
77BP1_19119308_ChIP-ChIP_Hs578T_Human1.08313247
78PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08109266
79* SMRT_27268052_Chip-Seq_Bcells_Human1.08036502
80ER_23166858_ChIP-Seq_MCF-7_Human1.08012418
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.07911343
82TCF4_18268006_ChIP-ChIP_LS174T_Human1.07770567
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07721333
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07117628
85FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07075342
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07001068
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05986533
88TP63_23658742_ChIP-Seq_EP156T_Human1.05377800
89* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03549722
90E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02605546
91CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02229723
92ESR1_21235772_ChIP-Seq_MCF-7_Human1.01301740
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01240895
94SCL_19346495_ChIP-Seq_HPC-7_Human1.00470719
95* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00375394
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00016662
97PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99827411
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99718277
99SALL1_21062744_ChIP-ChIP_HESCs_Human0.99484023
100* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99135800
101VDR_24763502_ChIP-Seq_THP-1_Human0.98213663
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97668072
103NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97517803
104STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97436625
105TP63_19390658_ChIP-ChIP_HaCaT_Human0.97322817
106* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97012740
107VDR_21846776_ChIP-Seq_THP-1_Human0.96568880
108EZH2_27294783_Chip-Seq_NPCs_Mouse0.96211234
109* GATA3_27048872_Chip-Seq_THYMUS_Human0.95863491
110* MYB_26560356_Chip-Seq_TH2_Human0.95831610
111CBP_20019798_ChIP-Seq_JUKART_Human0.94608785
112IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94608785
113* FLI1_21867929_ChIP-Seq_TH2_Mouse0.94287519
114CJUN_26792858_Chip-Seq_BT549_Human0.94040685
115SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93967670
116EP300_21415370_ChIP-Seq_HL-1_Mouse0.93598176
117NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93195870
118* ISL1_27105846_Chip-Seq_CPCs_Mouse0.92782362
119PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92562533
120SMAD3_21741376_ChIP-Seq_HESCs_Human0.92350360
121* GATA2_19941826_ChIP-Seq_K562_Human0.92109598
122ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91649571
123RNF2_27304074_Chip-Seq_ESCs_Mouse0.91223197
124NANOG_18555785_Chip-Seq_ESCs_Mouse0.91163252
125IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91125869
126* P300_19829295_ChIP-Seq_ESCs_Human0.90515242
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90424323
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90424323
129AR_25329375_ChIP-Seq_VCAP_Human0.90293692
130UTX_26944678_Chip-Seq_JUKART_Human0.90146003
131* PU_27001747_Chip-Seq_BMDM_Mouse0.89991669
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89918650
133SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89385099
134MYB_26560356_Chip-Seq_TH1_Human0.89354424
135TP53_16413492_ChIP-PET_HCT116_Human0.89247096
136* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88621128
137CDX2_22108803_ChIP-Seq_LS180_Human0.88522936
138GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88172909
139TBX20_22080862_ChIP-Seq_HEART_Mouse0.88022995
140TBX20_22328084_ChIP-Seq_HEART_Mouse0.88022995
141* BRD4_25478319_ChIP-Seq_HGPS_Human0.87927297
142SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87079430
143SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87079430
144RUNX1_27514584_Chip-Seq_MCF-7_Human0.85250622
145FOXA2_19822575_ChIP-Seq_HepG2_Human0.84997818
146AR_19668381_ChIP-Seq_PC3_Human0.83041108

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.79385650
2MP0000569_abnormal_digit_pigmentation4.13256808
3MP0004510_myositis3.87519900
4MP0003303_peritoneal_inflammation3.31317681
5MP0002254_reproductive_system_inflammat3.29521169
6MP0002138_abnormal_hepatobiliary_system3.25951176
7MP0003300_gastrointestinal_ulcer2.89605201
8MP0003787_abnormal_imprinting2.75875455
9MP0005076_abnormal_cell_differentiation2.70721427
10MP0000685_abnormal_immune_system2.64289792
11MP0001835_abnormal_antigen_presentation2.59135671
12MP0008961_abnormal_basal_metabolism2.51771544
13MP0002166_altered_tumor_susceptibility2.45065775
14MP0005387_immune_system_phenotype2.40304492
15MP0001790_abnormal_immune_system2.40304492
16MP0002006_tumorigenesis2.23948675
17MP0003724_increased_susceptibility_to2.08883882
18MP0002877_abnormal_melanocyte_morpholog2.02841829
19MP0010352_gastrointestinal_tract_polyps2.02732784
20MP0001346_abnormal_lacrimal_gland2.01747364
21MP0003436_decreased_susceptibility_to1.93810260
22MP0001800_abnormal_humoral_immune1.91590807
23MP0005310_abnormal_salivary_gland1.89020250
24MP0008877_abnormal_DNA_methylation1.84000423
25MP0003091_abnormal_cell_migration1.75404926
26MP0004947_skin_inflammation1.73744615
27MP0010234_abnormal_vibrissa_follicle1.70631051
28MP0002009_preneoplasia1.69756944
29MP0005000_abnormal_immune_tolerance1.67816516
30MP0003950_abnormal_plasma_membrane1.67148215
31MP0002452_abnormal_antigen_presenting1.66527792
32MP0005671_abnormal_response_to1.56621854
33MP0003045_fibrosis1.52632098
34MP0003705_abnormal_hypodermis_morpholog1.51180585
35MP0001348_abnormal_lacrimal_gland1.48999024
36MP0001819_abnormal_immune_cell1.47621608
37MP0002723_abnormal_immune_serum1.46985761
38MP0003763_abnormal_thymus_physiology1.46523624
39MP0004808_abnormal_hematopoietic_stem1.46014600
40MP0002420_abnormal_adaptive_immunity1.45682713
41MP0005167_abnormal_blood-brain_barrier1.43962654
42MP0002398_abnormal_bone_marrow1.35782091
43MP0001873_stomach_inflammation1.34296854
44MP0003183_abnormal_peptide_metabolism1.33252044
45MP0002148_abnormal_hypersensitivity_rea1.30794302
46MP0009278_abnormal_bone_marrow1.28173809
47MP0002168_other_aberrant_phenotype1.27273068
48MP0001853_heart_inflammation1.25820313
49MP0002405_respiratory_system_inflammati1.24460594
50MP0002419_abnormal_innate_immunity1.24046826
51MP0003453_abnormal_keratinocyte_physiol1.21002818
52MP0000716_abnormal_immune_system1.20131123
53MP0009785_altered_susceptibility_to1.18504130
54MP0003890_abnormal_embryonic-extraembry1.17071025
55MP0002332_abnormal_exercise_endurance1.15520293
56MP0005187_abnormal_penis_morphology1.13994966
57MP0005025_abnormal_response_to1.13769445
58MP0003566_abnormal_cell_adhesion1.13630781
59MP0005248_abnormal_Harderian_gland1.12756085
60MP0003656_abnormal_erythrocyte_physiolo1.12481664
61MP0010155_abnormal_intestine_physiology1.08793957
62MP0002396_abnormal_hematopoietic_system1.06967739
63MP0001545_abnormal_hematopoietic_system1.06209413
64MP0005397_hematopoietic_system_phenotyp1.06209413
65MP0000733_abnormal_muscle_development1.05704777
66MP0004381_abnormal_hair_follicle1.04454864
67MP0010368_abnormal_lymphatic_system0.97316236
68MP0004858_abnormal_nervous_system0.97230351
69MP0001879_abnormal_lymphatic_vessel0.95572750
70MP0000427_abnormal_hair_cycle0.95550136
71MP0009115_abnormal_fat_cell0.95069821
72MP0002998_abnormal_bone_remodeling0.95003880
73MP0009780_abnormal_chondrocyte_physiolo0.94083144
74MP0004264_abnormal_extraembryonic_tissu0.92986411
75MP0005275_abnormal_skin_tensile0.90458912
76MP0000703_abnormal_thymus_morphology0.89729775
77MP0003866_abnormal_defecation0.89200146
78MP0004185_abnormal_adipocyte_glucose0.88375803
79MP0001533_abnormal_skeleton_physiology0.88080479
80MP0000767_abnormal_smooth_muscle0.87966764
81MP0003448_altered_tumor_morphology0.86387835
82MP0006054_spinal_hemorrhage0.86142259
83MP0002928_abnormal_bile_duct0.85997899
84MP0001845_abnormal_inflammatory_respons0.85018074
85MP0002429_abnormal_blood_cell0.84289840
86MP0008004_abnormal_stomach_pH0.83577003
87MP0009333_abnormal_splenocyte_physiolog0.83375531
88MP0003828_pulmonary_edema0.83314650
89MP0006082_CNS_inflammation0.82824372
90MP0000778_abnormal_nervous_system0.81284370
91MP0002163_abnormal_gland_morphology0.80762542
92MP0003195_calcinosis0.80690113
93MP0002933_joint_inflammation0.80683427
94MP0004859_abnormal_synaptic_plasticity0.80604918
95MP0001849_ear_inflammation0.78467823
96MP0005647_abnormal_sex_gland0.77315910
97MP0000579_abnormal_nail_morphology0.77094853
98MP0002722_abnormal_immune_system0.76978172
99MP0004484_altered_response_of0.76120212
100MP0008469_abnormal_protein_level0.75672576
101MP0005395_other_phenotype0.75148131
102MP0000371_diluted_coat_color0.74972421
103MP0003868_abnormal_feces_composition0.74529741
104MP0000465_gastrointestinal_hemorrhage0.74291461
105MP0010307_abnormal_tumor_latency0.73990260
106MP0000383_abnormal_hair_follicle0.73427027
107MP0001191_abnormal_skin_condition0.73182867
108MP0009764_decreased_sensitivity_to0.72893180
109MP0001501_abnormal_sleep_pattern0.72616201
110MP0002925_abnormal_cardiovascular_devel0.72216649
111MP0005621_abnormal_cell_physiology0.71361837
112MP0005623_abnormal_meninges_morphology0.71249111
113MP0010678_abnormal_skin_adnexa0.71220272
114MP0000015_abnormal_ear_pigmentation0.70674806
115MP0003121_genomic_imprinting0.70466519
116MP0000604_amyloidosis0.69128535
117MP0001851_eye_inflammation0.68181661
118MP0000689_abnormal_spleen_morphology0.67830261
119MP0005164_abnormal_response_to0.67129965
120MP0005499_abnormal_olfactory_system0.66461282
121MP0005394_taste/olfaction_phenotype0.66461282
122MP0005464_abnormal_platelet_physiology0.66296544
123MP0008775_abnormal_heart_ventricle0.66221588
124MP0010630_abnormal_cardiac_muscle0.65247292
125MP0000249_abnormal_blood_vessel0.65014479
126MP0003646_muscle_fatigue0.64121410
127MP0005451_abnormal_body_composition0.64058733
128MP0001881_abnormal_mammary_gland0.64019726
129MP0000003_abnormal_adipose_tissue0.63948920
130MP0001502_abnormal_circadian_rhythm0.63478197
131MP0001216_abnormal_epidermal_layer0.62707130
132MP0008789_abnormal_olfactory_epithelium0.62439688
133MP0005023_abnormal_wound_healing0.61355884
134MP0001270_distended_abdomen0.60867072
135MP0000627_abnormal_mammary_gland0.60248760
136MP0003172_abnormal_lysosome_physiology0.59109912

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.75665242
2Fair hair (HP:0002286)3.18386227
3Autoimmune hemolytic anemia (HP:0001890)3.15568441
4Papillary thyroid carcinoma (HP:0002895)3.07575822
5Acute myeloid leukemia (HP:0004808)2.97219523
6Optic neuritis (HP:0100653)2.93673654
7Retrobulbar optic neuritis (HP:0100654)2.93673654
8Protruding tongue (HP:0010808)2.85266470
9Cortical dysplasia (HP:0002539)2.79004831
10Abnormality of T cell number (HP:0011839)2.78162482
11Arterial thrombosis (HP:0004420)2.77096084
12Lip pit (HP:0100267)2.73152235
13Neoplasm of the tracheobronchial system (HP:0100552)2.71144007
14Recurrent fungal infections (HP:0002841)2.70889950
15Orchitis (HP:0100796)2.70567554
16Stomach cancer (HP:0012126)2.70261970
17IgA deficiency (HP:0002720)2.67226274
18Recurrent viral infections (HP:0004429)2.66100045
19Stomatitis (HP:0010280)2.64697606
20Generalized hypopigmentation of hair (HP:0011358)2.62428396
21Eczematoid dermatitis (HP:0000976)2.60501965
22T lymphocytopenia (HP:0005403)2.59031538
23Genetic anticipation (HP:0003743)2.55802500
24Pulmonary infiltrates (HP:0002113)2.47354630
25Fatigue (HP:0012378)2.47274468
26Myositis (HP:0100614)2.46912866
27Hematochezia (HP:0002573)2.45884150
28Hypoplastic iliac wings (HP:0002866)2.43953439
29Trigonocephaly (HP:0000243)2.41030995
30Recurrent bronchitis (HP:0002837)2.40622573
31Abnormality of incisor morphology (HP:0011063)2.36217691
32Gastrointestinal infarctions (HP:0005244)2.35230121
33Agammaglobulinemia (HP:0004432)2.34812011
34Widely spaced teeth (HP:0000687)2.34201376
35Narrow palate (HP:0000189)2.32988938
36Colitis (HP:0002583)2.30140572
37Keratoconjunctivitis (HP:0001096)2.29374727
38Autoimmune thrombocytopenia (HP:0001973)2.29112105
39Anhidrosis (HP:0000970)2.27114340
40Mediastinal lymphadenopathy (HP:0100721)2.26826866
41Macroorchidism (HP:0000053)2.24257625
42Gastrointestinal stroma tumor (HP:0100723)2.23780801
43Hyperacusis (HP:0010780)2.22216251
44Prominent nose (HP:0000448)2.22081926
45Ectropion (HP:0000656)2.19350056
46Gaze-evoked nystagmus (HP:0000640)2.18240012
47Chronic mucocutaneous candidiasis (HP:0002728)2.18089233
48Recurrent cutaneous fungal infections (HP:0011370)2.18089233
49Hyperventilation (HP:0002883)2.16771389
50Chronic diarrhea (HP:0002028)2.15722892
51Heterotopia (HP:0002282)2.15528912
52Alveolar cell carcinoma (HP:0006519)2.14406462
53Transitional cell carcinoma of the bladder (HP:0006740)2.14005975
54Recurrent bacterial skin infections (HP:0005406)2.12970974
55Neonatal hypoglycemia (HP:0001998)2.12813305
56Chest pain (HP:0100749)2.11222903
57Long eyelashes (HP:0000527)2.08588966
58Thoracolumbar scoliosis (HP:0002944)2.08512355
59Abnormality of the nasal septum (HP:0000419)2.07663864
60Spontaneous hematomas (HP:0007420)2.05215373
61Myocardial infarction (HP:0001658)2.04065803
62Peritonitis (HP:0002586)2.04009127
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.03948406
64Midline defect of the nose (HP:0004122)2.03451636
65Polycythemia (HP:0001901)2.01682354
66Hemoptysis (HP:0002105)2.01667182
67Recurrent abscess formation (HP:0002722)1.99674811
68Leiomyosarcoma (HP:0100243)1.99266778
69Uterine leiomyosarcoma (HP:0002891)1.99266778
70Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.99067503
71Cellulitis (HP:0100658)1.95642832
72Bladder carcinoma (HP:0002862)1.95574865
73Bladder neoplasm (HP:0009725)1.95574865
74Abnormality of T cells (HP:0002843)1.94966072
75Thyroiditis (HP:0100646)1.94674336
76Esophageal varix (HP:0002040)1.94248822
77Vasculitis (HP:0002633)1.92798246
78Febrile seizures (HP:0002373)1.91827719
79Abnormality of the gastric mucosa (HP:0004295)1.91152827
80Aortic aneurysm (HP:0004942)1.90549610
81Progressive cerebellar ataxia (HP:0002073)1.88267146
82Viral hepatitis (HP:0006562)1.87845048
83Hypoplastic labia majora (HP:0000059)1.87114205
84Abnormal pancreas size (HP:0012094)1.86210241
85Cutis marmorata (HP:0000965)1.85747588
86Increased IgE level (HP:0003212)1.84996144
87Volvulus (HP:0002580)1.84832186
88Cerebral aneurysm (HP:0004944)1.84559158
89Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.83978500
90Abnormal hair whorl (HP:0010721)1.83910196
91Curly hair (HP:0002212)1.83606497
92Interstitial pulmonary disease (HP:0006530)1.82927724
93Depressed nasal tip (HP:0000437)1.81668972
94Clumsiness (HP:0002312)1.81621073
95Abnormality of T cell physiology (HP:0011840)1.81231562
96Urethral obstruction (HP:0000796)1.80968702
97Deep philtrum (HP:0002002)1.80233758
98Periodontitis (HP:0000704)1.80123744
99Arterial tortuosity (HP:0005116)1.79790387
100Meningitis (HP:0001287)1.79686097
101Vertebral arch anomaly (HP:0008438)1.79431085
102Low anterior hairline (HP:0000294)1.77852143
103Subacute progressive viral hepatitis (HP:0006572)1.77783450
104Inflammation of the large intestine (HP:0002037)1.77119081
105Tapered finger (HP:0001182)1.76513195
106Recurrent sinusitis (HP:0011108)1.76298810
107Chronic hepatic failure (HP:0100626)1.76208368
108Thyroid carcinoma (HP:0002890)1.75059067
109Overgrowth (HP:0001548)1.73742798
110Aqueductal stenosis (HP:0002410)1.73569698
111Lymphopenia (HP:0001888)1.73240782
112Absent frontal sinuses (HP:0002688)1.73235548
113Elevated erythrocyte sedimentation rate (HP:0003565)1.72060339
114Chronic otitis media (HP:0000389)1.71550691
115Hyperkalemia (HP:0002153)1.70568482
116Abnormality of the epiphyses of the hand (HP:0005924)1.70360383
117Abnormality of the labia majora (HP:0012881)1.70124560
118Dysmetric saccades (HP:0000641)1.70047200
119Long toe (HP:0010511)1.69743907
120Gastrointestinal inflammation (HP:0004386)1.69384935
121Gangrene (HP:0100758)1.68472825
122Urinary bladder sphincter dysfunction (HP:0002839)1.68305976
123Abnormality of the columella (HP:0009929)1.67906953
124Gingivitis (HP:0000230)1.67877816
125Coarse hair (HP:0002208)1.67809684
126Persistence of primary teeth (HP:0006335)1.67408822
127Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.67220937
128Papilledema (HP:0001085)1.66946488
129Portal hypertension (HP:0001409)1.66805969
130Thick eyebrow (HP:0000574)1.66368837
131Aneurysm (HP:0002617)1.66035879
132Abnormality of cells of the lymphoid lineage (HP:0012140)1.65966955
133Leukocytosis (HP:0001974)1.65809306
134Emphysema (HP:0002097)1.65002209
135Cubitus valgus (HP:0002967)1.64524802
136Hip dysplasia (HP:0001385)1.63751863
137Short 4th metacarpal (HP:0010044)1.63702192
138Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.63702192
139Panhypogammaglobulinemia (HP:0003139)1.62948621
140Aplasia cutis congenita (HP:0001057)1.61691629
141Milia (HP:0001056)1.61105627
142Truncal obesity (HP:0001956)1.60747133
143Abnormality of the intervertebral disk (HP:0005108)1.60160525
144Spondylolisthesis (HP:0003302)1.59351112
145Nasal polyposis (HP:0100582)1.57784254
146Porencephaly (HP:0002132)1.56120263
147Enlarged penis (HP:0000040)1.55772230
148Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.55757329
149Insulin-resistant diabetes mellitus (HP:0000831)1.55387497
150Recurrent skin infections (HP:0001581)1.54946312
151Abnormality of the peritoneum (HP:0002585)1.54844165
152Limited elbow extension (HP:0001377)1.54828607
153Abnormality of the hepatic vasculature (HP:0006707)1.53676720
154Elfin facies (HP:0004428)1.53205309
155Vascular tortuosity (HP:0004948)1.51621496
156Keratoconjunctivitis sicca (HP:0001097)1.51272277
157Oligodontia (HP:0000677)1.50787992

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K142.90262503
2FRK2.78097719
3LATS12.54942791
4JAK32.33346079
5CHUK2.33190223
6AKT32.31708362
7MAP3K132.27967239
8RIPK12.26826980
9TAOK32.17264466
10TAOK12.13768917
11FGFR32.02452704
12JAK12.01864982
13CDK121.99938132
14MAP3K101.95441296
15DMPK1.92871795
16TYK21.80533138
17MAP3K91.78334189
18TBK11.76910797
19CAMK1G1.74434789
20EPHA31.71750009
21IKBKE1.69039787
22BMPR21.67398355
23TRIB31.64723144
24IKBKB1.63673358
25EEF2K1.51862239
26MAP4K11.51105251
27SIK21.51062605
28IRAK31.49240709
29ERN11.47689119
30CAMK1D1.44067849
31TNIK1.37878994
32SGK31.34832025
33SIK11.27912861
34TRPM71.24468065
35RIPK41.16266408
36SIK31.15732259
37FGFR41.11969020
38EPHB11.08456428
39PRKAA21.08413128
40PRKD31.08128789
41SGK21.07505974
42STK31.07135564
43RET1.06998303
44TEC1.06782159
45MATK1.05875108
46PIK3CG1.04630219
47PTK61.03366804
48PRPF4B1.02318178
49NTRK21.01355498
50IRAK41.01142896
51MAP3K70.99731418
52JAK20.99614569
53BLK0.97936694
54EIF2AK30.97374997
55EPHB20.96758916
56MTOR0.92051310
57NEK90.91023125
58LATS20.90931318
59YES10.88264122
60CDK90.84342877
61MAP3K60.84168800
62STK100.83272632
63STK110.80285326
64STK38L0.80044042
65HIPK20.78483250
66NUAK10.77603908
67ICK0.76378286
68ACVR1B0.75582055
69PAK60.73938490
70MELK0.71710371
71DAPK20.71312516
72ITK0.70400138
73SGK10.70386073
74IRAK20.70219966
75PRKAA10.70069704
76LCK0.69540732
77NLK0.68640334
78MAPK70.68248862
79GRK70.67170057
80PDGFRB0.67146809
81STK240.67107497
82PIK3CA0.66148702
83KSR20.65123941
84HCK0.64551410
85MST40.63605777
86CDC42BPA0.63297461
87MARK20.63061070
88MARK30.63015675
89KIT0.62400942
90MAPK110.62245194
91TTN0.62111138
92MAP3K10.61521266
93CAMKK20.59573221
94SYK0.58952072
95ABL10.58031915
96RPS6KA40.57973687
97ZAP700.57577985
98ADRBK20.54884636
99PRKCH0.54739983
100FGR0.54529310
101DDR20.53652605
102LYN0.53448015
103INSRR0.53356230
104STK380.53052413
105IRAK10.52381187
106PRKCZ0.52332848
107ERBB30.51619319
108CDK60.51093614
109RPS6KA10.50861390
110MAP3K40.50155332
111MAP3K50.49961704
112BTK0.49773558
113RAF10.48800720
114MKNK20.45665694
115SGK2230.45615655
116SGK4940.45615655
117TYRO30.45590022
118MAPK10.44679740
119PKN20.44311194
120PRKD20.44249127
121PIM10.44231805
122MAP3K20.43961037
123KSR10.43409896
124TGFBR20.42014978
125WNK10.41944410
126TXK0.41811589
127BMX0.41497119
128MAPK100.40802451
129AKT10.40724941
130CSK0.40683668
131CAMK40.40680662
132ALK0.40509869
133BRD40.40387701
134MAPKAPK20.40088342
135MARK10.39965062
136PRKCQ0.39822764
137CDK40.39430048

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040641.81622461
2Osteoclast differentiation_Homo sapiens_hsa043801.71182999
3Leishmaniasis_Homo sapiens_hsa051401.66919356
4Autoimmune thyroid disease_Homo sapiens_hsa053201.61686615
5Toxoplasmosis_Homo sapiens_hsa051451.56849813
6TNF signaling pathway_Homo sapiens_hsa046681.56528329
7Dorso-ventral axis formation_Homo sapiens_hsa043201.52330383
8B cell receptor signaling pathway_Homo sapiens_hsa046621.49077144
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.47315290
10Type II diabetes mellitus_Homo sapiens_hsa049301.41819424
11Chronic myeloid leukemia_Homo sapiens_hsa052201.41052660
12Prolactin signaling pathway_Homo sapiens_hsa049171.34529989
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34518552
14Pancreatic cancer_Homo sapiens_hsa052121.33586231
15Chemokine signaling pathway_Homo sapiens_hsa040621.30319811
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.26731374
17Viral myocarditis_Homo sapiens_hsa054161.23068886
18Prostate cancer_Homo sapiens_hsa052151.22876264
19Neurotrophin signaling pathway_Homo sapiens_hsa047221.22100815
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21542745
21Thyroid hormone signaling pathway_Homo sapiens_hsa049191.21373188
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20256572
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19881624
24Small cell lung cancer_Homo sapiens_hsa052221.18317949
25Measles_Homo sapiens_hsa051621.16306621
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.14599560
27T cell receptor signaling pathway_Homo sapiens_hsa046601.12928000
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12337699
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11424920
30Acute myeloid leukemia_Homo sapiens_hsa052211.11103940
31MicroRNAs in cancer_Homo sapiens_hsa052061.08607558
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07268128
33Influenza A_Homo sapiens_hsa051641.05948127
34Tuberculosis_Homo sapiens_hsa051521.05387327
35Endometrial cancer_Homo sapiens_hsa052131.05342309
36Insulin resistance_Homo sapiens_hsa049311.03219955
37mTOR signaling pathway_Homo sapiens_hsa041501.03146605
38Hepatitis B_Homo sapiens_hsa051611.02857211
39Adherens junction_Homo sapiens_hsa045201.02169158
40Allograft rejection_Homo sapiens_hsa053300.99322463
41Apoptosis_Homo sapiens_hsa042100.98824526
42Malaria_Homo sapiens_hsa051440.98020322
43Staphylococcus aureus infection_Homo sapiens_hsa051500.96175590
44Rheumatoid arthritis_Homo sapiens_hsa053230.96169965
45Primary immunodeficiency_Homo sapiens_hsa053400.94736386
46Colorectal cancer_Homo sapiens_hsa052100.94657919
47Adipocytokine signaling pathway_Homo sapiens_hsa049200.94630182
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94260099
49MAPK signaling pathway_Homo sapiens_hsa040100.93390839
50African trypanosomiasis_Homo sapiens_hsa051430.92697364
51Olfactory transduction_Homo sapiens_hsa047400.91241301
52Platelet activation_Homo sapiens_hsa046110.91239470
53Glioma_Homo sapiens_hsa052140.90332455
54Herpes simplex infection_Homo sapiens_hsa051680.90160583
55Notch signaling pathway_Homo sapiens_hsa043300.89467901
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88847158
57VEGF signaling pathway_Homo sapiens_hsa043700.88307038
58Non-small cell lung cancer_Homo sapiens_hsa052230.85691876
59Dilated cardiomyopathy_Homo sapiens_hsa054140.85186952
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85092691
61ErbB signaling pathway_Homo sapiens_hsa040120.84941276
62GnRH signaling pathway_Homo sapiens_hsa049120.84813395
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84013416
64Legionellosis_Homo sapiens_hsa051340.83509025
65FoxO signaling pathway_Homo sapiens_hsa040680.83002895
66Renal cell carcinoma_Homo sapiens_hsa052110.82283053
67Proteoglycans in cancer_Homo sapiens_hsa052050.82055233
68Viral carcinogenesis_Homo sapiens_hsa052030.81683043
69Estrogen signaling pathway_Homo sapiens_hsa049150.80942404
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80656636
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80202273
72Lysine degradation_Homo sapiens_hsa003100.79099747
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78696653
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.78062315
75HTLV-I infection_Homo sapiens_hsa051660.78053558
76Circadian rhythm_Homo sapiens_hsa047100.77283322
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76726564
78Focal adhesion_Homo sapiens_hsa045100.76653047
79Hepatitis C_Homo sapiens_hsa051600.75900726
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.75576771
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75403582
82Amoebiasis_Homo sapiens_hsa051460.74394016
83Hematopoietic cell lineage_Homo sapiens_hsa046400.74375933
84Cholinergic synapse_Homo sapiens_hsa047250.74164273
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.74125500
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73765596
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73709724
88Salmonella infection_Homo sapiens_hsa051320.73278171
89Antigen processing and presentation_Homo sapiens_hsa046120.72912905
90Choline metabolism in cancer_Homo sapiens_hsa052310.72298003
91Oxytocin signaling pathway_Homo sapiens_hsa049210.72242615
92Epstein-Barr virus infection_Homo sapiens_hsa051690.71491960
93cAMP signaling pathway_Homo sapiens_hsa040240.71175729
94Axon guidance_Homo sapiens_hsa043600.71003812
95Type I diabetes mellitus_Homo sapiens_hsa049400.70753362
96Graft-versus-host disease_Homo sapiens_hsa053320.67993658
97Renin secretion_Homo sapiens_hsa049240.67606273
98Pertussis_Homo sapiens_hsa051330.67502887
99HIF-1 signaling pathway_Homo sapiens_hsa040660.67055212
100Gastric acid secretion_Homo sapiens_hsa049710.66567472
101Insulin signaling pathway_Homo sapiens_hsa049100.66327600
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66260358
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65878824
104Inositol phosphate metabolism_Homo sapiens_hsa005620.65226629
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65087042
106Asthma_Homo sapiens_hsa053100.65085812
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64771846
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64110118
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64052859
110Circadian entrainment_Homo sapiens_hsa047130.63555713
111Insulin secretion_Homo sapiens_hsa049110.63151132
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62852204
113Shigellosis_Homo sapiens_hsa051310.62561974
114Pathways in cancer_Homo sapiens_hsa052000.62483604
115ABC transporters_Homo sapiens_hsa020100.60345280
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56270814
117TGF-beta signaling pathway_Homo sapiens_hsa043500.54731571
118Bladder cancer_Homo sapiens_hsa052190.46353451
119Thyroid cancer_Homo sapiens_hsa052160.44652067
120Ras signaling pathway_Homo sapiens_hsa040140.44478203
121Long-term depression_Homo sapiens_hsa047300.44110548

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