HJURP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.03124216
2mitotic chromosome condensation (GO:0007076)5.80888098
3DNA unwinding involved in DNA replication (GO:0006268)5.79425319
4sister chromatid segregation (GO:0000819)5.35440594
5mitotic sister chromatid segregation (GO:0000070)5.15167324
6protein localization to chromosome, centromeric region (GO:0071459)5.14157877
7mitotic sister chromatid cohesion (GO:0007064)4.89801820
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.80026677
9DNA ligation (GO:0006266)4.53072938
10nuclear pore complex assembly (GO:0051292)4.47925055
11kinetochore organization (GO:0051383)4.35021221
12nuclear pore organization (GO:0006999)4.34967277
13regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.31830144
14regulation of spindle organization (GO:0090224)4.12295951
15DNA duplex unwinding (GO:0032508)4.07446475
16DNA geometric change (GO:0032392)4.06222744
17establishment of integrated proviral latency (GO:0075713)4.04832863
18chromosome condensation (GO:0030261)4.04613577
19DNA strand elongation involved in DNA replication (GO:0006271)4.02198752
20dosage compensation (GO:0007549)3.95581537
21attachment of spindle microtubules to kinetochore (GO:0008608)3.93772763
22translesion synthesis (GO:0019985)3.89825511
23mitotic recombination (GO:0006312)3.88356720
24regulation of histone H3-K9 methylation (GO:0051570)3.87524983
25DNA strand elongation (GO:0022616)3.85485145
26DNA topological change (GO:0006265)3.82378309
27mitotic nuclear envelope disassembly (GO:0007077)3.80298523
28telomere maintenance via semi-conservative replication (GO:0032201)3.79255627
29DNA replication initiation (GO:0006270)3.77028297
30mitotic metaphase plate congression (GO:0007080)3.73910352
31protein localization to chromosome (GO:0034502)3.68958217
32meiotic chromosome segregation (GO:0045132)3.68436639
33regulation of centrosome cycle (GO:0046605)3.67954518
34DNA conformation change (GO:0071103)3.61774734
35metaphase plate congression (GO:0051310)3.59538455
36DNA replication-dependent nucleosome organization (GO:0034723)3.57333437
37DNA replication-dependent nucleosome assembly (GO:0006335)3.57333437
38negative regulation of histone methylation (GO:0031061)3.57284318
39nuclear envelope disassembly (GO:0051081)3.56784779
40membrane disassembly (GO:0030397)3.56784779
41regulation of DNA endoreduplication (GO:0032875)3.56102911
42telomere maintenance via recombination (GO:0000722)3.54168579
43DNA packaging (GO:0006323)3.49443990
44folic acid-containing compound biosynthetic process (GO:0009396)3.47153203
45negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.45429679
46regulation of mitotic spindle organization (GO:0060236)3.44321213
47regulation of sister chromatid cohesion (GO:0007063)3.43011638
48regulation of chromosome segregation (GO:0051983)3.41497798
49negative regulation of mitosis (GO:0045839)3.38620854
50* DNA replication-independent nucleosome assembly (GO:0006336)3.36456875
51* DNA replication-independent nucleosome organization (GO:0034724)3.36456875
52positive regulation of chromosome segregation (GO:0051984)3.35368975
53* CENP-A containing nucleosome assembly (GO:0034080)3.33638543
54* chromatin remodeling at centromere (GO:0031055)3.33420224
55spindle checkpoint (GO:0031577)3.33182259
56* chromatin assembly or disassembly (GO:0006333)3.32516362
57spindle assembly checkpoint (GO:0071173)3.31937449
58mitotic G2/M transition checkpoint (GO:0044818)3.30700687
59* chromosome segregation (GO:0007059)3.28791132
60mitotic cell cycle (GO:0000278)3.28534268
61kinetochore assembly (GO:0051382)3.28093220
62DNA replication checkpoint (GO:0000076)3.26622417
63positive regulation of mitotic sister chromatid separation (GO:1901970)3.25224655
64positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.25224655
65positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.25224655
66somatic hypermutation of immunoglobulin genes (GO:0016446)3.25097165
67somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25097165
68establishment of chromosome localization (GO:0051303)3.23258635
69regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.22867170
70pore complex assembly (GO:0046931)3.22022241
71spindle assembly involved in mitosis (GO:0090307)3.21294372
72pre-miRNA processing (GO:0031054)3.20567986
73negative regulation of RNA splicing (GO:0033119)3.19841677
74histone-serine phosphorylation (GO:0035404)3.19558564
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.18888168
76negative regulation of chromosome segregation (GO:0051985)3.18654686
77regulation of mitotic metaphase/anaphase transition (GO:0030071)3.15947026
78protein K6-linked ubiquitination (GO:0085020)3.14389414
79mitotic spindle organization (GO:0007052)3.13951143
80mitotic spindle assembly checkpoint (GO:0007094)3.12446661
81negative regulation of mitotic sister chromatid separation (GO:2000816)3.12257571
82negative regulation of mitotic sister chromatid segregation (GO:0033048)3.12257571
83negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.12257571
84negative regulation of sister chromatid segregation (GO:0033046)3.12257571
85regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.09405845
86negative regulation of fibroblast apoptotic process (GO:2000270)3.09241982
87chromosome organization (GO:0051276)3.09107923
88negative regulation of mRNA processing (GO:0050686)3.09055028
89ventricular cardiac muscle cell development (GO:0055015)3.08523332
90DNA strand renaturation (GO:0000733)3.07507328
91postreplication repair (GO:0006301)3.07187519
92chromatin assembly (GO:0031497)3.05629213
93establishment of mitotic spindle localization (GO:0040001)3.04889492
94regulation of spindle checkpoint (GO:0090231)3.04595751
95negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.03901027
96mitotic nuclear division (GO:0007067)3.02959543
97nucleotide-excision repair, DNA gap filling (GO:0006297)3.02792512
98negative regulation of cell division (GO:0051782)3.02783884
99regulation of centrosome duplication (GO:0010824)3.02340204
100double-strand break repair via nonhomologous end joining (GO:0006303)3.02338494
101non-recombinational repair (GO:0000726)3.02338494
102mitotic spindle checkpoint (GO:0071174)3.02329995
103spindle organization (GO:0007051)3.01744117
104establishment of viral latency (GO:0019043)3.00866190
105heterochromatin organization (GO:0070828)3.00844472
106regulation of mitotic sister chromatid segregation (GO:0033047)3.00660239
107regulation of sister chromatid segregation (GO:0033045)3.00660239
108regulation of mitotic sister chromatid separation (GO:0010965)3.00660239
109negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.00256670
110RNA stabilization (GO:0043489)2.98390388
111mRNA stabilization (GO:0048255)2.98390388
112mitotic cytokinesis (GO:0000281)2.97159860
113regulation of centriole replication (GO:0046599)2.96134481
114telomere maintenance via telomere lengthening (GO:0010833)2.95078073
115IMP biosynthetic process (GO:0006188)2.93915960
116histone H3-K36 demethylation (GO:0070544)2.92064934
117positive regulation of histone H3-K4 methylation (GO:0051571)2.89628810
118tetrahydrofolate metabolic process (GO:0046653)2.87452075
119* ATP-dependent chromatin remodeling (GO:0043044)2.86172488
120DNA synthesis involved in DNA repair (GO:0000731)2.84222389
121nuclear envelope organization (GO:0006998)2.83376000
122mismatch repair (GO:0006298)2.81162295
123* histone exchange (GO:0043486)2.80557122
124negative regulation of mRNA metabolic process (GO:1903312)2.79667371
125microtubule depolymerization (GO:0007019)2.74844187

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human7.25516193
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.50685600
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.04006262
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.26273456
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.55857589
6E2F1_21310950_ChIP-Seq_MCF-7_Human2.44345606
7AR_21909140_ChIP-Seq_LNCAP_Human2.40318515
8MYC_22102868_ChIP-Seq_BL_Human2.38242858
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.32710379
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.17014227
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.12908825
12THAP11_20581084_ChIP-Seq_MESCs_Mouse2.10940948
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.09026574
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03765510
15E2F7_22180533_ChIP-Seq_HELA_Human11.7319437
16CIITA_25753668_ChIP-Seq_RAJI_Human1.85597772
17MYC_19079543_ChIP-ChIP_MESCs_Mouse1.85590756
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83561457
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81393738
20MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79698044
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74189992
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71492313
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71221113
24VDR_21846776_ChIP-Seq_THP-1_Human1.70628977
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.68379024
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.63011955
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.54920857
28XRN2_22483619_ChIP-Seq_HELA_Human1.54037353
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52000296
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43925335
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42794726
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41969554
33* FOXP3_21729870_ChIP-Seq_TREG_Human1.39528777
34* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38761945
35KDM5A_27292631_Chip-Seq_BREAST_Human1.37611232
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35896870
37* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31794060
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31076679
39* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30422984
40TCF7_22412390_ChIP-Seq_EML_Mouse1.29807358
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29565740
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27095177
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.24780630
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24068280
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21405252
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21239308
47* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20996350
48E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19663552
49SCL_19346495_ChIP-Seq_HPC-7_Human1.18518690
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18481771
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18439008
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17979635
53* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17722709
54MYC_18940864_ChIP-ChIP_HL60_Human1.16255961
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11228936
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10900456
57VDR_23849224_ChIP-Seq_CD4+_Human1.09830388
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09193104
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.08764103
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07646569
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.07625582
62MAF_26560356_Chip-Seq_TH1_Human1.07279472
63* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07071854
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06506699
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06459789
66UTX_26944678_Chip-Seq_JUKART_Human1.05429871
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05363714
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.05001208
69TTF2_22483619_ChIP-Seq_HELA_Human1.04443145
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.04117427
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03412351
72CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03016739
73GABP_19822575_ChIP-Seq_HepG2_Human1.02664415
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02205848
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01723417
76EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01674647
77MYB_26560356_Chip-Seq_TH1_Human1.00604588
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00448829
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00390985
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99561179
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99546712
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99444091
83EST1_17652178_ChIP-ChIP_JURKAT_Human0.98629478
84MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98596421
85KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98415429
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96969608
87E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96233767
88ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95595250
89PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95274316
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95177051
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.95171980
92HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.95062564
93* RXR_22158963_ChIP-Seq_LIVER_Mouse0.94888294
94NANOG_21062744_ChIP-ChIP_HESCs_Human0.93743107
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.93334903
96MYB_26560356_Chip-Seq_TH2_Human0.91891731
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91002282
98DCP1A_22483619_ChIP-Seq_HELA_Human0.90358007
99MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89215050
100* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89129182
101SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88193301
102RUNX1_22412390_ChIP-Seq_EML_Mouse0.87609720
103KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87007813
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86661854
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86548746
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86253227
107CHD1_26751641_Chip-Seq_LNCaP_Human0.86132484
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84650453
109* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84552059
110ELK1_19687146_ChIP-ChIP_HELA_Human0.84543331
111NCOR1_26117541_ChIP-Seq_K562_Human0.84487450
112POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83731984
113TFEB_21752829_ChIP-Seq_HELA_Human0.83549999
114VDR_24763502_ChIP-Seq_THP-1_Human0.82779980
115NOTCH1_21737748_ChIP-Seq_TLL_Human0.82568221
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.82223966
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81112122
118* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80808057
119KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79906162
120SPI1_23547873_ChIP-Seq_NB4_Human0.79844036
121ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.79501257
122CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78977832
123ETS1_20019798_ChIP-Seq_JURKAT_Human0.76902594
124GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76582658
125IRF1_19129219_ChIP-ChIP_H3396_Human0.73998756
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72560490
127EWS_26573619_Chip-Seq_HEK293_Human0.67105749
128* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.66529816
129CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.63223746
130KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.62395784
131KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.62395784
132KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.62395784
133HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.61947799

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.35994037
2MP0003111_abnormal_nucleus_morphology3.94556029
3MP0003693_abnormal_embryo_hatching3.49563326
4MP0003077_abnormal_cell_cycle3.24920732
5MP0003718_maternal_effect2.87897751
6MP0008057_abnormal_DNA_replication2.74135572
7MP0004957_abnormal_blastocyst_morpholog2.72470039
8MP0002396_abnormal_hematopoietic_system2.70165110
9MP0003705_abnormal_hypodermis_morpholog2.61953329
10MP0008007_abnormal_cellular_replicative2.59424687
11MP0006292_abnormal_olfactory_placode2.41546343
12MP0010352_gastrointestinal_tract_polyps2.36741259
13MP0008058_abnormal_DNA_repair2.35309462
14MP0004808_abnormal_hematopoietic_stem2.28038266
15MP0010307_abnormal_tumor_latency2.26593425
16MP0002139_abnormal_hepatobiliary_system2.21305470
17MP0009278_abnormal_bone_marrow2.09772272
18MP0000350_abnormal_cell_proliferation1.90070798
19MP0005360_urolithiasis1.89237917
20MP0000569_abnormal_digit_pigmentation1.87293879
21MP0001730_embryonic_growth_arrest1.79027583
22MP0005076_abnormal_cell_differentiation1.76669961
23MP0003121_genomic_imprinting1.63225437
24MP0003941_abnormal_skin_development1.61877293
25MP0003123_paternal_imprinting1.60589518
26MP0008932_abnormal_embryonic_tissue1.57842188
27MP0008877_abnormal_DNA_methylation1.56601690
28MP0001672_abnormal_embryogenesis/_devel1.54944472
29MP0005380_embryogenesis_phenotype1.54944472
30MP0004197_abnormal_fetal_growth/weight/1.54820142
31MP0001545_abnormal_hematopoietic_system1.48352091
32MP0005397_hematopoietic_system_phenotyp1.48352091
33MP0002086_abnormal_extraembryonic_tissu1.43160433
34MP0000703_abnormal_thymus_morphology1.42865248
35MP0001697_abnormal_embryo_size1.41645201
36MP0002088_abnormal_embryonic_growth/wei1.40451572
37MP0003984_embryonic_growth_retardation1.40430316
38MP0005365_abnormal_bile_salt1.36685117
39MP0000490_abnormal_crypts_of1.36409399
40MP0003567_abnormal_fetal_cardiomyocyte1.33176039
41MP0001929_abnormal_gametogenesis1.32740988
42MP0002019_abnormal_tumor_incidence1.32630579
43MP0002080_prenatal_lethality1.31782240
44MP0005085_abnormal_gallbladder_physiolo1.28677629
45MP0002085_abnormal_embryonic_tissue1.28190986
46MP0003763_abnormal_thymus_physiology1.28186398
47MP0002084_abnormal_developmental_patter1.22498706
48MP0001346_abnormal_lacrimal_gland1.22380697
49MP0001286_abnormal_eye_development1.20045031
50MP0003890_abnormal_embryonic-extraembry1.18816665
51MP0002398_abnormal_bone_marrow1.18372083
52MP0010030_abnormal_orbit_morphology1.18309613
53MP0009672_abnormal_birth_weight1.17265210
54MP0003252_abnormal_bile_duct1.16841790
55MP0002938_white_spotting1.16032623
56MP0000313_abnormal_cell_death1.13476801
57MP0009053_abnormal_anal_canal1.11486538
58MP0003943_abnormal_hepatobiliary_system1.09893015
59MP0002722_abnormal_immune_system1.09705361
60MP0006054_spinal_hemorrhage1.08854701
61MP0003787_abnormal_imprinting1.08308695
62MP0003136_yellow_coat_color1.04995235
63MP0004264_abnormal_extraembryonic_tissu1.03277088
64MP0008789_abnormal_olfactory_epithelium1.02746863
65MP0000689_abnormal_spleen_morphology1.00340534
66MP0004147_increased_porphyrin_level0.99646579
67MP0005023_abnormal_wound_healing0.99116539
68MP0003786_premature_aging0.98422549
69MP0009703_decreased_birth_body0.98222722
70MP0003300_gastrointestinal_ulcer0.96646269
71MP0001293_anophthalmia0.96339928
72MP0003699_abnormal_female_reproductive0.96307176
73MP0000566_synostosis0.95624197
74MP0003119_abnormal_digestive_system0.94808366
75MP0001529_abnormal_vocalization0.93089810
76MP0003806_abnormal_nucleotide_metabolis0.93076342
77MP0005464_abnormal_platelet_physiology0.92423458
78MP0003861_abnormal_nervous_system0.91851911
79MP0005395_other_phenotype0.91727540
80MP0000598_abnormal_liver_morphology0.91194389
81MP0003950_abnormal_plasma_membrane0.90908888
82MP0002233_abnormal_nose_morphology0.90576923
83MP0001915_intracranial_hemorrhage0.90344792
84MP0000049_abnormal_middle_ear0.90229536
85MP0005174_abnormal_tail_pigmentation0.89488652
86MP0003566_abnormal_cell_adhesion0.88940607
87MP0003436_decreased_susceptibility_to0.88924422
88MP0002092_abnormal_eye_morphology0.87278125
89MP0002160_abnormal_reproductive_system0.85445730
90MP0000428_abnormal_craniofacial_morphol0.85265063
91MP0003755_abnormal_palate_morphology0.85233411
92MP0000358_abnormal_cell_content/0.84794656
93MP0006035_abnormal_mitochondrial_morpho0.84131779
94MP0002166_altered_tumor_susceptibility0.83175835
95MP0002429_abnormal_blood_cell0.83159117
96MP0002161_abnormal_fertility/fecundity0.82895666
97MP0002210_abnormal_sex_determination0.82707348
98MP0002234_abnormal_pharynx_morphology0.82668674
99MP0000537_abnormal_urethra_morphology0.82506737
100MP0003315_abnormal_perineum_morphology0.82356691
101MP0010329_abnormal_lipoprotein_level0.81493788
102MP0003935_abnormal_craniofacial_develop0.79986180
103MP0000609_abnormal_liver_physiology0.79675712
104MP0003937_abnormal_limbs/digits/tail_de0.79528497
105MP0005499_abnormal_olfactory_system0.79499650
106MP0005394_taste/olfaction_phenotype0.79499650
107MP0009379_abnormal_foot_pigmentation0.79490988
108MP0001119_abnormal_female_reproductive0.79431373
109MP0001849_ear_inflammation0.76669227
110MP0005501_abnormal_skin_physiology0.76615624
111MP0003698_abnormal_male_reproductive0.75901003
112MP0001800_abnormal_humoral_immune0.75410521
113MP0003115_abnormal_respiratory_system0.75392031
114MP0001145_abnormal_male_reproductive0.74551807
115MP0000477_abnormal_intestine_morphology0.73878261
116MP0000733_abnormal_muscle_development0.72745215
117MP0002877_abnormal_melanocyte_morpholog0.72538886
118MP0000371_diluted_coat_color0.72436578
119MP0010155_abnormal_intestine_physiology0.72175222
120MP0000716_abnormal_immune_system0.70835901
121MP0002697_abnormal_eye_size0.70212864
122MP0009697_abnormal_copulation0.69317424
123MP0002111_abnormal_tail_morphology0.68742765
124MP0005621_abnormal_cell_physiology0.67496990
125MP0000653_abnormal_sex_gland0.66899079
126MP0002095_abnormal_skin_pigmentation0.66683854
127MP0002970_abnormal_white_adipose0.66412981
128MP0004233_abnormal_muscle_weight0.65987486
129MP0000432_abnormal_head_morphology0.65566210
130MP0008875_abnormal_xenobiotic_pharmacok0.65524661
131MP0005187_abnormal_penis_morphology0.65119770
132MP0009763_increased_sensitivity_to0.64036659
133MP0005384_cellular_phenotype0.63850791
134MP0002925_abnormal_cardiovascular_devel0.63481415
135MP0000647_abnormal_sebaceous_gland0.63255902
136MP0003656_abnormal_erythrocyte_physiolo0.60693827
137MP0000631_abnormal_neuroendocrine_gland0.58988303
138MP0003186_abnormal_redox_activity0.58193079
139MP0000762_abnormal_tongue_morphology0.57714880
140MP0009250_abnormal_appendicular_skeleto0.57388315
141MP0001727_abnormal_embryo_implantation0.56997513
142MP0000372_irregular_coat_pigmentation0.55560764
143MP0004185_abnormal_adipocyte_glucose0.55405182
144MP0002081_perinatal_lethality0.54436825

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.90325564
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.83094897
3Cortical dysplasia (HP:0002539)3.62911371
4Ependymoma (HP:0002888)3.56454107
5Increased nuchal translucency (HP:0010880)3.39697279
6Volvulus (HP:0002580)3.38484285
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.37190509
8Short 4th metacarpal (HP:0010044)3.37190509
9Medulloblastoma (HP:0002885)3.26573369
10Hyperacusis (HP:0010780)3.02784867
11Rhabdomyosarcoma (HP:0002859)3.00115600
12Abnormality of chromosome stability (HP:0003220)2.95188577
13Renovascular hypertension (HP:0100817)2.92879113
14Aplasia/Hypoplasia of the sacrum (HP:0008517)2.85069001
15Absent radius (HP:0003974)2.81325672
16Impulsivity (HP:0100710)2.78616539
17Abnormality of the fingertips (HP:0001211)2.73466644
18Abnormality of the labia minora (HP:0012880)2.71598105
19Aplasia involving forearm bones (HP:0009822)2.66905175
20Absent forearm bone (HP:0003953)2.66905175
21Astrocytoma (HP:0009592)2.65551161
22Abnormality of the astrocytes (HP:0100707)2.65551161
23Selective tooth agenesis (HP:0001592)2.64217482
24Abnormality of pyrimidine metabolism (HP:0004353)2.62082754
25Abnormality of the 4th metacarpal (HP:0010012)2.59069268
26Horseshoe kidney (HP:0000085)2.58558738
27Neoplasm of striated muscle (HP:0009728)2.45576845
28Triphalangeal thumb (HP:0001199)2.44581928
29Ectopic kidney (HP:0000086)2.42824622
30Aplasia/Hypoplasia of the sternum (HP:0006714)2.42519538
31Myelodysplasia (HP:0002863)2.41919551
32Absent thumb (HP:0009777)2.41716921
33Elfin facies (HP:0004428)2.36691299
34Renal duplication (HP:0000075)2.35013259
35Meckel diverticulum (HP:0002245)2.34304049
36Abnormality of the carotid arteries (HP:0005344)2.34057617
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.31705839
38Reticulocytopenia (HP:0001896)2.30978945
39Carpal bone hypoplasia (HP:0001498)2.28104353
40Proximal placement of thumb (HP:0009623)2.27833056
41Hypochromic microcytic anemia (HP:0004840)2.27594724
42Embryonal neoplasm (HP:0002898)2.25538286
43Hypoplasia of the capital femoral epiphysis (HP:0003090)2.25096918
44Duplicated collecting system (HP:0000081)2.24646293
45Glioma (HP:0009733)2.24293218
46Breast hypoplasia (HP:0003187)2.23432699
47Agnosia (HP:0010524)2.23393507
48Colon cancer (HP:0003003)2.23310893
49High anterior hairline (HP:0009890)2.23202131
50Abnormality of the ileum (HP:0001549)2.22137146
51Hypoplastic pelvis (HP:0008839)2.21111799
52Basal cell carcinoma (HP:0002671)2.20167369
53Deviation of the thumb (HP:0009603)2.19867815
54Duplication of thumb phalanx (HP:0009942)2.19055599
55Short thumb (HP:0009778)2.19044911
56Small intestinal stenosis (HP:0012848)2.18512980
57Duodenal stenosis (HP:0100867)2.18512980
58Cafe-au-lait spot (HP:0000957)2.18050842
59Pseudobulbar signs (HP:0002200)2.16476417
60Abnormality of the preputium (HP:0100587)2.15642353
61High pitched voice (HP:0001620)2.14836677
62Choanal atresia (HP:0000453)2.14025140
63Prostate neoplasm (HP:0100787)2.11996431
64Obsessive-compulsive behavior (HP:0000722)2.11570760
65Neoplasm of the colon (HP:0100273)2.10912940
66Deep venous thrombosis (HP:0002625)2.10537535
67Prominent nose (HP:0000448)2.10457964
68Spastic diplegia (HP:0001264)2.08863591
69Facial hemangioma (HP:0000329)2.07192153
70Heterotopia (HP:0002282)2.06629742
71Squamous cell carcinoma (HP:0002860)2.05804444
72Abnormality of the duodenum (HP:0002246)2.05332695
73Cutis marmorata (HP:0000965)2.04353383
74Abnormal number of incisors (HP:0011064)2.01561915
75Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.97713078
76Acute myeloid leukemia (HP:0004808)1.97609727
77Broad palm (HP:0001169)1.97505685
78Acute lymphatic leukemia (HP:0006721)1.96467279
79Cerebellar dysplasia (HP:0007033)1.96271099
80Truncal obesity (HP:0001956)1.94535929
81Skull defect (HP:0001362)1.94534964
82Gastrointestinal carcinoma (HP:0002672)1.94317856
83Malignant gastrointestinal tract tumors (HP:0006749)1.94317856
84Abnormality of the renal collecting system (HP:0004742)1.93720727
85Birth length less than 3rd percentile (HP:0003561)1.93514269
86Absent epiphyses (HP:0010577)1.93321266
87Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.93321266
88Multiple enchondromatosis (HP:0005701)1.90044136
89Increased mean platelet volume (HP:0011877)1.89048064
90Anterior segment dysgenesis (HP:0007700)1.86634858
91Biliary tract neoplasm (HP:0100574)1.85393179
92Abnormal platelet volume (HP:0011876)1.85128354
93Abnormality of the prostate (HP:0008775)1.84973834
94Overriding aorta (HP:0002623)1.84216277
95Sloping forehead (HP:0000340)1.83849771
96Abnormality of cochlea (HP:0000375)1.83274179
97Abnormality of DNA repair (HP:0003254)1.82648199
98Thrombocytosis (HP:0001894)1.80611997
99Facial cleft (HP:0002006)1.80487953
100Long eyelashes (HP:0000527)1.79818307
101Clubbing of toes (HP:0100760)1.77437322
102Broad distal phalanx of finger (HP:0009836)1.77370365
103Nephroblastoma (Wilms tumor) (HP:0002667)1.76570478
104Supernumerary spleens (HP:0009799)1.76174633
105Macroorchidism (HP:0000053)1.75899248
106Poikiloderma (HP:0001029)1.75062624
107Amaurosis fugax (HP:0100576)1.74716549
108Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.74240759
109Abnormality of cells of the erythroid lineage (HP:0012130)1.74024398
110Patellar aplasia (HP:0006443)1.73806092
111Abnormal lung lobation (HP:0002101)1.73627293
112Irregular epiphyses (HP:0010582)1.72946197
113Skin tags (HP:0010609)1.72944653
114Bowel diverticulosis (HP:0005222)1.71904901
115Microvesicular hepatic steatosis (HP:0001414)1.71316271
116Deep philtrum (HP:0002002)1.71185561
117Hypobetalipoproteinemia (HP:0003563)1.70664827
118Bone marrow hypocellularity (HP:0005528)1.70134007
119Megalocornea (HP:0000485)1.69156350
120Tracheoesophageal fistula (HP:0002575)1.68630819
121Abnormality of chromosome segregation (HP:0002916)1.68389827
12211 pairs of ribs (HP:0000878)1.68197145
123Abnormality of the proximal phalanges of the hand (HP:0009834)1.68134925
124Enlarged penis (HP:0000040)1.67857278
125Abnormality of abdominal situs (HP:0011620)1.67577413
126Abdominal situs inversus (HP:0003363)1.67577413
127Atresia of the external auditory canal (HP:0000413)1.66976667
128Sandal gap (HP:0001852)1.66343431
129Abnormality of the septum pellucidum (HP:0007375)1.66317460
130Neoplasm of the pancreas (HP:0002894)1.65930135
131Abnormal gallbladder physiology (HP:0012438)1.65867584
132Cholecystitis (HP:0001082)1.65867584
133Small epiphyses (HP:0010585)1.65423665
134Absent septum pellucidum (HP:0001331)1.65413003
135Aplasia/Hypoplasia of the patella (HP:0006498)1.65287560
136Premature ovarian failure (HP:0008209)1.64334521
137Intestinal polyp (HP:0005266)1.64148824
138Abnormality of reticulocytes (HP:0004312)1.63623055
139Intestinal polyposis (HP:0200008)1.63226585
140Embryonal renal neoplasm (HP:0011794)1.63158947
141Abnormality of monocarboxylic acid metabolism (HP:0010996)1.63111270
142Abnormality of the calcaneus (HP:0008364)1.62064390
143Lymphoma (HP:0002665)1.61691174
144Overlapping toe (HP:0001845)1.61416953
145Freckling (HP:0001480)1.60935355
146Missing ribs (HP:0000921)1.60667100
147Abnormal number of erythroid precursors (HP:0012131)1.60474321
148Arteriovenous malformation (HP:0100026)1.59902416
149Cleft eyelid (HP:0000625)1.59387351
150Oligodactyly (hands) (HP:0001180)1.59098576
151Capillary hemangiomas (HP:0005306)1.58743156
152Leiomyosarcoma (HP:0100243)1.58372251
153Uterine leiomyosarcoma (HP:0002891)1.58372251
154Oligodactyly (HP:0012165)1.58140316
155Holoprosencephaly (HP:0001360)1.57540702
156Septo-optic dysplasia (HP:0100842)1.56976038

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.24791175
2MAP3K103.66796181
3NEK23.44114108
4EEF2K3.33645130
5PIK3CG3.21939783
6PKN22.84226246
7CDK122.80609120
8VRK22.66366162
9PBK2.58105944
10WEE12.45773635
11FLT32.43452520
12EIF2AK12.38549455
13TTK2.23091396
14TRIB32.17503575
15BUB11.95325293
16CDK41.88297129
17ATR1.80001536
18PASK1.76600542
19TAF11.66846932
20PLK11.66684598
21BRD41.63587845
22NEK11.61978497
23STK101.61594482
24AURKB1.57592303
25CDK61.57160851
26RPS6KB21.55315841
27CDK71.50218714
28STK41.43054781
29SRPK11.41389582
30CHEK21.34570723
31PNCK1.30315701
32BRSK21.30272592
33CHEK11.28484299
34TLK11.26699932
35BRAF1.26629625
36MAP3K81.24523836
37CCNB11.24508046
38TGFBR11.22455973
39SMG11.21504143
40RPS6KA41.16144912
41MKNK11.14455431
42ACVR1B1.14419646
43PTK61.14025375
44KIT1.13184793
45MAP4K11.12936946
46SIK11.12645672
47CSF1R1.11459991
48EIF2AK31.06821379
49CLK11.04876428
50STK31.03619023
51ATM1.03044066
52DYRK31.00126108
53BRSK10.98333608
54MAP2K30.95877079
55STK160.95833527
56MELK0.95133087
57EIF2AK20.93127210
58MAPK110.90738249
59PAK40.90201452
60MTOR0.88892197
61NUAK10.85776526
62PLK40.84534501
63CDK20.82921230
64NME20.82840795
65TRIM280.81389791
66MST40.79506443
67PLK30.77541215
68TTN0.74530635
69LRRK20.74007447
70ERN10.73046459
71BTK0.72797380
72GRK60.72696665
73PIM10.72125502
74TSSK60.71592441
75LATS10.71358588
76ERBB40.70890013
77FGFR40.70698543
78MKNK20.69622965
79NEK90.68869664
80CDK10.68424900
81SIK20.67719197
82CAMK1D0.66294308
83MET0.64929021
84CDK90.64811496
85YES10.64670700
86DYRK1B0.62366974
87MST1R0.59778019
88AURKA0.59404627
89RIPK10.59081099
90FGFR30.57373380
91ALK0.56968114
92SCYL20.55457257
93TYK20.55166047
94NME10.52987145
95VRK10.50342362
96PDGFRA0.49808022
97CDK80.48002787
98ERBB30.47647609
99TNIK0.47333795
100CDK11A0.47093148
101PRKCI0.47054297
102ERBB20.46811801
103CDK150.45960117
104CDK180.45554464
105PAK10.45094148
106PRKDC0.44502106
107FGFR10.43399827
108AKT20.42921279
109MARK30.41338529
110CSNK2A10.40895338
111MATK0.40613950
112CSNK2A20.40239152
113ZAK0.40071186
114ICK0.39820186
115RPS6KL10.37636737
116RPS6KC10.37636737
117MAPK140.37325996
118CSNK1E0.36562534
119CDK30.36518975
120FRK0.36139298
121CDK140.36039286
122RPS6KA60.34974158
123TRPM70.34332295
124CAMK1G0.34199381
125MAPK10.33700297
126CHUK0.32966608
127* AKT10.31963437
128LATS20.31664339
129PDGFRB0.31613138
130MAP3K70.31315832
131PAK20.31109614
132UHMK10.30892051
133ZAP700.29734649
134MAP3K90.27015767
135CSNK1G10.22869239
136PLK20.22834039
137TESK20.22631233
138EPHA20.20276268
139GSK3B0.20010589
140BMPR1B0.19794782
141RAF10.17706564
142BMX0.15988173
143CSNK1G30.14586820

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.31117302
2Mismatch repair_Homo sapiens_hsa034303.73541774
3One carbon pool by folate_Homo sapiens_hsa006703.08015992
4Cell cycle_Homo sapiens_hsa041102.84948302
5Base excision repair_Homo sapiens_hsa034102.60953477
6Proteasome_Homo sapiens_hsa030502.42259110
7Fanconi anemia pathway_Homo sapiens_hsa034602.32807461
8Homologous recombination_Homo sapiens_hsa034402.30182898
9Spliceosome_Homo sapiens_hsa030402.11322163
10RNA polymerase_Homo sapiens_hsa030202.11108356
11Non-homologous end-joining_Homo sapiens_hsa034501.97024117
12RNA transport_Homo sapiens_hsa030131.91795741
13Nucleotide excision repair_Homo sapiens_hsa034201.87314899
14Selenocompound metabolism_Homo sapiens_hsa004501.85045414
15Lysine degradation_Homo sapiens_hsa003101.79605532
16mRNA surveillance pathway_Homo sapiens_hsa030151.71942701
17Systemic lupus erythematosus_Homo sapiens_hsa053221.66833617
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.55725218
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39378761
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34916087
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.32981148
22Chronic myeloid leukemia_Homo sapiens_hsa052201.30531246
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.29650983
24Small cell lung cancer_Homo sapiens_hsa052221.28238048
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.25456707
26p53 signaling pathway_Homo sapiens_hsa041151.23977914
27Nitrogen metabolism_Homo sapiens_hsa009101.19362272
28Viral carcinogenesis_Homo sapiens_hsa052031.18600416
29Caffeine metabolism_Homo sapiens_hsa002321.12957978
30MicroRNAs in cancer_Homo sapiens_hsa052061.12226168
31Non-small cell lung cancer_Homo sapiens_hsa052231.10877743
32Purine metabolism_Homo sapiens_hsa002301.10625343
33RNA degradation_Homo sapiens_hsa030181.06263429
34Protein export_Homo sapiens_hsa030601.03393287
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02704505
36HTLV-I infection_Homo sapiens_hsa051661.02319068
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01680146
38Pyrimidine metabolism_Homo sapiens_hsa002401.01527528
39Biosynthesis of amino acids_Homo sapiens_hsa012301.00702434
40Pyruvate metabolism_Homo sapiens_hsa006201.00094754
41Sulfur relay system_Homo sapiens_hsa041220.99940410
42Central carbon metabolism in cancer_Homo sapiens_hsa052300.97758995
43Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97737205
44Herpes simplex infection_Homo sapiens_hsa051680.96430260
45Steroid biosynthesis_Homo sapiens_hsa001000.94936340
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.94860036
47Acute myeloid leukemia_Homo sapiens_hsa052210.93467438
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.91137700
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87595852
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85536567
51Complement and coagulation cascades_Homo sapiens_hsa046100.84327499
52Pancreatic cancer_Homo sapiens_hsa052120.84297221
53Arginine biosynthesis_Homo sapiens_hsa002200.83252959
54Colorectal cancer_Homo sapiens_hsa052100.83179480
55Tryptophan metabolism_Homo sapiens_hsa003800.78888747
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78801201
57B cell receptor signaling pathway_Homo sapiens_hsa046620.78336693
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76533388
59Primary immunodeficiency_Homo sapiens_hsa053400.76053682
60mTOR signaling pathway_Homo sapiens_hsa041500.76003129
61Hepatitis B_Homo sapiens_hsa051610.74628134
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74283947
63Endometrial cancer_Homo sapiens_hsa052130.73790078
64Vitamin B6 metabolism_Homo sapiens_hsa007500.73070431
65Huntingtons disease_Homo sapiens_hsa050160.72442640
66Hippo signaling pathway_Homo sapiens_hsa043900.71969788
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71225430
68Glutathione metabolism_Homo sapiens_hsa004800.69245076
69Pentose phosphate pathway_Homo sapiens_hsa000300.68915324
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68258339
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67180905
72N-Glycan biosynthesis_Homo sapiens_hsa005100.66477727
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66008706
74Oocyte meiosis_Homo sapiens_hsa041140.65148598
75Measles_Homo sapiens_hsa051620.63806369
76Epstein-Barr virus infection_Homo sapiens_hsa051690.62181186
77Adherens junction_Homo sapiens_hsa045200.61692199
78Ribosome_Homo sapiens_hsa030100.60845364
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59737137
80TGF-beta signaling pathway_Homo sapiens_hsa043500.59313288
81Fatty acid degradation_Homo sapiens_hsa000710.58413969
82Notch signaling pathway_Homo sapiens_hsa043300.58399609
83Fatty acid elongation_Homo sapiens_hsa000620.58336600
84Insulin resistance_Homo sapiens_hsa049310.58190054
85Prostate cancer_Homo sapiens_hsa052150.57665940
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55400115
87Apoptosis_Homo sapiens_hsa042100.55196105
88Bladder cancer_Homo sapiens_hsa052190.54296833
89Thyroid cancer_Homo sapiens_hsa052160.54244684
90Staphylococcus aureus infection_Homo sapiens_hsa051500.54119500
91Basal cell carcinoma_Homo sapiens_hsa052170.53398440
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.52526850
93Antigen processing and presentation_Homo sapiens_hsa046120.52059506
94FoxO signaling pathway_Homo sapiens_hsa040680.51355008
95Wnt signaling pathway_Homo sapiens_hsa043100.49678358
96Carbon metabolism_Homo sapiens_hsa012000.49600335
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49105765
98Parkinsons disease_Homo sapiens_hsa050120.49054297
99Propanoate metabolism_Homo sapiens_hsa006400.48279685
100AMPK signaling pathway_Homo sapiens_hsa041520.47647482
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47314108
102Basal transcription factors_Homo sapiens_hsa030220.46751313
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46013715
104ABC transporters_Homo sapiens_hsa020100.45552704
105Prolactin signaling pathway_Homo sapiens_hsa049170.45137799
106Folate biosynthesis_Homo sapiens_hsa007900.44748538
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43543846
108Influenza A_Homo sapiens_hsa051640.43266345
109Legionellosis_Homo sapiens_hsa051340.43216263
110PPAR signaling pathway_Homo sapiens_hsa033200.43178014
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42684057
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42588689
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.40943418
114Proteoglycans in cancer_Homo sapiens_hsa052050.39680320
115Alcoholism_Homo sapiens_hsa050340.39456551
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39009988
117Glioma_Homo sapiens_hsa052140.38796674
118Hedgehog signaling pathway_Homo sapiens_hsa043400.38577601
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38242396
120Retinol metabolism_Homo sapiens_hsa008300.38166569
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38121426
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38004650
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37423649
124T cell receptor signaling pathway_Homo sapiens_hsa046600.36860677
125Toxoplasmosis_Homo sapiens_hsa051450.36448851
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34067667
127Melanoma_Homo sapiens_hsa052180.31915793
128Metabolic pathways_Homo sapiens_hsa011000.31218853
129Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29691043
130Oxidative phosphorylation_Homo sapiens_hsa001900.27910199
131Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20169601
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17993116
133Pathways in cancer_Homo sapiens_hsa052000.15939959
134Gap junction_Homo sapiens_hsa045400.15284188
135Arginine and proline metabolism_Homo sapiens_hsa003300.14453995
136Fructose and mannose metabolism_Homo sapiens_hsa000510.14233612
137Galactose metabolism_Homo sapiens_hsa000520.14221101
138Tight junction_Homo sapiens_hsa045300.12088065
139Alzheimers disease_Homo sapiens_hsa050100.08086852
140Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.07341855

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