HK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms, some of which are tissue-specific. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)6.58373967
2sperm motility (GO:0030317)6.01483430
3epithelial cilium movement (GO:0003351)5.91018017
4fusion of sperm to egg plasma membrane (GO:0007342)5.45746918
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.44491302
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.17560553
7sperm capacitation (GO:0048240)4.96767035
8synaptic vesicle maturation (GO:0016188)4.94915297
9sodium ion export (GO:0071436)4.93061157
10protoporphyrinogen IX metabolic process (GO:0046501)4.83847293
11plasma membrane fusion (GO:0045026)4.76129639
12acrosome assembly (GO:0001675)4.70695356
13cilium movement (GO:0003341)4.59478752
14cell wall macromolecule metabolic process (GO:0044036)4.51899620
15cell wall macromolecule catabolic process (GO:0016998)4.51899620
16calcium ion-dependent exocytosis (GO:0017156)4.49805815
17Golgi transport vesicle coating (GO:0048200)4.46946742
18COPI coating of Golgi vesicle (GO:0048205)4.46946742
19positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.40808592
20protein localization to endosome (GO:0036010)4.36286498
21cellular potassium ion homeostasis (GO:0030007)4.31364523
22sperm-egg recognition (GO:0035036)4.30161611
23adenosine receptor signaling pathway (GO:0001973)4.22024995
24locomotory exploration behavior (GO:0035641)4.19869865
25glutamate secretion (GO:0014047)4.16600665
26negative regulation of inclusion body assembly (GO:0090084)4.13781222
27spermatid development (GO:0007286)4.01139082
28layer formation in cerebral cortex (GO:0021819)3.98226268
29multicellular organism reproduction (GO:0032504)3.97931385
30regulation of early endosome to late endosome transport (GO:2000641)3.97830603
31synaptic vesicle exocytosis (GO:0016079)3.96922237
32cilium or flagellum-dependent cell motility (GO:0001539)3.92211251
33cell-cell recognition (GO:0009988)3.90068155
34nuclear pore complex assembly (GO:0051292)3.89155000
35binding of sperm to zona pellucida (GO:0007339)3.81881908
36protoporphyrinogen IX biosynthetic process (GO:0006782)3.74910002
37negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.74043232
38regulation of cilium movement (GO:0003352)3.71004266
39reproduction (GO:0000003)3.69996945
40exploration behavior (GO:0035640)3.69667236
41regulation of synaptic vesicle exocytosis (GO:2000300)3.67912304
42regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.67705895
43negative regulation of organelle assembly (GO:1902116)3.63893841
44barbed-end actin filament capping (GO:0051016)3.63735149
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.63661955
46regulation of clathrin-mediated endocytosis (GO:2000369)3.62936461
47motile cilium assembly (GO:0044458)3.62468134
48retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.62404531
49membrane depolarization during action potential (GO:0086010)3.57320315
50regulation of ARF GTPase activity (GO:0032312)3.54809533
51regulation of nucleobase-containing compound transport (GO:0032239)3.54669386
52synaptic vesicle docking involved in exocytosis (GO:0016081)3.54195784
53positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.52601138
54axonemal dynein complex assembly (GO:0070286)3.51898618
55regulation of synapse structural plasticity (GO:0051823)3.49818733
56regulation of RNA export from nucleus (GO:0046831)3.48714271
57negative regulation of norepinephrine secretion (GO:0010700)3.43811989
58adherens junction assembly (GO:0034333)3.39916562
59left/right pattern formation (GO:0060972)3.39783913
60cell migration in hindbrain (GO:0021535)3.34957229
61cell communication by electrical coupling (GO:0010644)3.33448688
62CDP-diacylglycerol biosynthetic process (GO:0016024)3.33019256
63positive regulation of potassium ion transmembrane transport (GO:1901381)3.30196328
64positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.30186482
65vocalization behavior (GO:0071625)3.30089786
66proline transport (GO:0015824)3.28696406
67regulation of synaptic vesicle transport (GO:1902803)3.27635752
68membrane repolarization (GO:0086009)3.24518019
69regulation of translational fidelity (GO:0006450)3.24075595
70plasma membrane repair (GO:0001778)3.22249646
71gas transport (GO:0015669)3.21451735
72regulation of neuronal synaptic plasticity (GO:0048168)3.21401100
73regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.20970167
74regulation of NFAT protein import into nucleus (GO:0051532)3.20486309
75positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.20263984
76cellular sodium ion homeostasis (GO:0006883)3.18441553
77potassium ion import (GO:0010107)3.17697120
78protein localization to synapse (GO:0035418)3.17200521
79activation of protein kinase A activity (GO:0034199)3.16578225
80focal adhesion assembly (GO:0048041)3.16071076
81cell-substrate adherens junction assembly (GO:0007045)3.16071076
82oxygen transport (GO:0015671)3.15983914
83DNA unwinding involved in DNA replication (GO:0006268)3.15303206
84CDP-diacylglycerol metabolic process (GO:0046341)3.12280875
85regulation of histone H3-K27 methylation (GO:0061085)3.11849283
86stress fiber assembly (GO:0043149)3.11736005
87ventricular system development (GO:0021591)3.11027776
88nuclear pore organization (GO:0006999)3.10981240
89regulation of inclusion body assembly (GO:0090083)3.10143655
90prepulse inhibition (GO:0060134)3.08773789
91maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.07916600
92negative regulation of microtubule polymerization (GO:0031115)3.07410068
93regulation of calcium ion transmembrane transport (GO:1903169)3.06490703
94regulation of calcium ion transmembrane transporter activity (GO:1901019)3.06490703
95regulation of ARF protein signal transduction (GO:0032012)3.06369190
96negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.06327283
97cell-substrate junction assembly (GO:0007044)3.05703948
98neurotransmitter secretion (GO:0007269)3.05568415
99porphyrin-containing compound biosynthetic process (GO:0006779)3.05419440
100protein retention in ER lumen (GO:0006621)3.01288155
101regulation of glutamate receptor signaling pathway (GO:1900449)3.00720099
102regulation of long-term neuronal synaptic plasticity (GO:0048169)3.00038889
103regulation of protein kinase A signaling (GO:0010738)2.99960999
104response to pheromone (GO:0019236)2.97664001
105* glycolytic process (GO:0006096)2.97658314
106pore complex assembly (GO:0046931)2.97443211
107pentose-phosphate shunt (GO:0006098)2.95590538
108protein export from nucleus (GO:0006611)2.95532361
109ionotropic glutamate receptor signaling pathway (GO:0035235)2.94815804
110clathrin coat assembly (GO:0048268)2.94352491
111erythrocyte development (GO:0048821)2.92927097
112vesicle coating (GO:0006901)2.91744455
113nucleosome disassembly (GO:0006337)2.91015170
114protein-DNA complex disassembly (GO:0032986)2.91015170
1153-UTR-mediated mRNA stabilization (GO:0070935)2.90734331
116chaperone-mediated protein transport (GO:0072321)2.90384003
117erythrocyte maturation (GO:0043249)2.89707894
118proline biosynthetic process (GO:0006561)2.89367187
119positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.89126848
120epithelial cell-cell adhesion (GO:0090136)2.86754306
121neuronal action potential propagation (GO:0019227)2.86422909
122regulation of inositol phosphate biosynthetic process (GO:0010919)2.86057197
123protein targeting to plasma membrane (GO:0072661)2.85678682
124epithelial cell differentiation involved in prostate gland development (GO:0060742)2.85052989
125negative regulation of potassium ion transmembrane transport (GO:1901380)2.83752957
126cell communication involved in cardiac conduction (GO:0086065)2.82871373
127positive regulation of fibroblast migration (GO:0010763)2.82465828
128membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.81846728
129regulation of microtubule-based movement (GO:0060632)2.81840400
130positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.81402978
131negative regulation of erythrocyte differentiation (GO:0045647)2.80843448
132regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.79996902
133synaptonemal complex organization (GO:0070193)2.76717801
134regulation of penile erection (GO:0060405)2.75759388
135negative regulation of histone methylation (GO:0031061)2.75712992
136neuromuscular process controlling balance (GO:0050885)2.74733045
137regulation of potassium ion transmembrane transporter activity (GO:1901016)2.74263502
138mitotic chromosome condensation (GO:0007076)2.74068949
139sexual reproduction (GO:0019953)2.72226406
140cytoskeletal anchoring at plasma membrane (GO:0007016)2.71858081
141positive regulation of protein export from nucleus (GO:0046827)2.71760827
142potassium ion homeostasis (GO:0055075)2.71484873
143intracellular estrogen receptor signaling pathway (GO:0030520)2.71417789
144negative regulation of dendrite morphogenesis (GO:0050774)2.71282394
145regulation of voltage-gated calcium channel activity (GO:1901385)2.70358893
146protein complex localization (GO:0031503)2.68954115
147regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.65427530
148positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.63944632
149peptidyl-arginine omega-N-methylation (GO:0035247)2.62037763
150peptidyl-proline hydroxylation (GO:0019511)2.60967804
151cortical actin cytoskeleton organization (GO:0030866)2.60225586
152regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.58972685
153positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.58972685
154cellular protein complex localization (GO:0034629)2.58423045
155negative regulation of adherens junction organization (GO:1903392)2.58010635
156negative regulation of focal adhesion assembly (GO:0051895)2.58010635
157negative regulation of cell junction assembly (GO:1901889)2.58010635
158mRNA stabilization (GO:0048255)2.56598388
159RNA stabilization (GO:0043489)2.56598388
160cerebellar granule cell differentiation (GO:0021707)2.51049422
161cellular response to thyroid hormone stimulus (GO:0097067)2.49949076
162NADPH regeneration (GO:0006740)2.47926389
163glucocorticoid receptor signaling pathway (GO:0042921)2.44240158
164planar cell polarity pathway involved in neural tube closure (GO:0090179)2.43748207
165regulation of cAMP-dependent protein kinase activity (GO:2000479)2.43296585
166regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.42695273
167regulation of response to osmotic stress (GO:0047484)2.41166929
168activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.41019473
169iron ion import (GO:0097286)2.39689231
170actin filament capping (GO:0051693)2.37943656
171platelet formation (GO:0030220)2.37487978
172semaphorin-plexin signaling pathway (GO:0071526)2.36345854
173regulation of defense response to virus by virus (GO:0050690)2.35948648
174positive regulation of receptor recycling (GO:0001921)2.35876022
175cellular copper ion homeostasis (GO:0006878)2.35070964
176regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.34686964
177megakaryocyte development (GO:0035855)2.34265775
178negative regulation of cell size (GO:0045792)2.33932111
179positive regulation of nuclease activity (GO:0032075)2.33543068
180creatine metabolic process (GO:0006600)2.32542478

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.60587544
2E2F7_22180533_ChIP-Seq_HELA_Human3.24517873
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.23509127
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.85851742
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.83918879
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.57599579
7MYC_22102868_ChIP-Seq_BL_Human2.47235331
8REST_21632747_ChIP-Seq_MESCs_Mouse2.40141519
9* ELK3_25401928_ChIP-Seq_HUVEC_Human2.38258037
10* GATA1_19941826_ChIP-Seq_K562_Human2.28086568
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.26500726
12CLOCK_20551151_ChIP-Seq_293T_Human2.22487881
13SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22463833
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20711871
15* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.18121396
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.16471849
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15100978
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.13887925
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.10040323
20DROSHA_22980978_ChIP-Seq_HELA_Human2.08658544
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.08607073
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.05087750
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05065423
24RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02012416
25EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02012416
26TCF7_22412390_ChIP-Seq_EML_Mouse1.98132620
27* NCOR1_26117541_ChIP-Seq_K562_Human1.97789548
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.96834617
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.94280590
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.92948266
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90611028
32CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.88858685
33* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.87709569
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86685615
35* RACK7_27058665_Chip-Seq_MCF-7_Human1.85784032
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83527800
37VDR_21846776_ChIP-Seq_THP-1_Human1.83249890
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.82379069
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79238153
40GATA1_26923725_Chip-Seq_HPCs_Mouse1.79173048
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77652598
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77058907
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.75671393
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.72337815
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71204813
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.69592836
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69395588
48P300_27058665_Chip-Seq_ZR-75-30cells_Human1.69056890
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.68318068
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64302752
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63484142
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59310331
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.55553418
54RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.52787712
55* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51911719
56CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.51713698
57* KDM2B_26808549_Chip-Seq_JURKAT_Human1.51430373
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.51399717
59* KDM2B_26808549_Chip-Seq_K562_Human1.48753847
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46875781
61* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45138430
62RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44739954
63CTCF_27219007_Chip-Seq_Bcells_Human1.44702183
64* GATA2_19941826_ChIP-Seq_K562_Human1.43759998
65* GATA1_19941827_ChIP-Seq_MEL_Mouse1.42357122
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41899021
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41672147
68* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41437813
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.41382280
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41021828
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40950362
72GATA1_22025678_ChIP-Seq_K562_Human1.40317191
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.39953022
74ZNF274_21170338_ChIP-Seq_K562_Hela1.38138384
75* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37848159
76* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37763093
77TAF15_26573619_Chip-Seq_HEK293_Human1.35479907
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35205514
79ZNF263_19887448_ChIP-Seq_K562_Human1.32701132
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32078604
81WT1_19549856_ChIP-ChIP_CCG9911_Human1.30306874
82TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30086849
83ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29799340
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28556306
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28063861
86* KDM2B_26808549_Chip-Seq_DND41_Human1.27943375
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27116655
88* MAF_26560356_Chip-Seq_TH1_Human1.26234794
89KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26020006
90LXR_22292898_ChIP-Seq_THP-1_Human1.25110060
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23976074
92RING1B_27294783_Chip-Seq_ESCs_Mouse1.22161055
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21716603
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21606252
95PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21421854
96ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21080157
97SPI1_23127762_ChIP-Seq_K562_Human1.20074010
98TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19600794
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19548872
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19054348
101ELK4_26923725_Chip-Seq_MESODERM_Mouse1.16559491
102GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.15750322
103SMAD3_21741376_ChIP-Seq_ESCs_Human1.15279820
104SA1_27219007_Chip-Seq_ERYTHROID_Human1.15226857
105* CREB1_26743006_Chip-Seq_LNCaP_Human1.15165376
106* ATF3_27146783_Chip-Seq_COLON_Human1.15035292
107DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14053639
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13916441
109THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13878429
110NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13686816
111MYC_19079543_ChIP-ChIP_MESCs_Mouse1.13584127
112MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12509554
113EED_16625203_ChIP-ChIP_MESCs_Mouse1.12508722
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12276438
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11491987
116SCL_19346495_ChIP-Seq_HPC-7_Human1.09991161
117* ESR2_21235772_ChIP-Seq_MCF-7_Human1.09680920
118SMAD4_21799915_ChIP-Seq_A2780_Human1.08955052
119STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08079125
120DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07695902
121KLF4_19829295_ChIP-Seq_ESCs_Human1.07567481
122* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07152364
123* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07139789
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06933162
125PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05258941
126TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04536481
127* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04082820
128RUNX1_22412390_ChIP-Seq_EML_Mouse1.03336090
129TET1_21451524_ChIP-Seq_MESCs_Mouse1.03293172
130* TET1_21490601_ChIP-Seq_MESCs_Mouse1.03166387
131* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02758475
132NANOG_21062744_ChIP-ChIP_HESCs_Human1.01892745
133ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01679633
134* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01650914
135STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01482559
136ERG_21242973_ChIP-ChIP_JURKAT_Human1.01315168
137OCT4_19829295_ChIP-Seq_ESCs_Human1.01124028
138EP300_21415370_ChIP-Seq_HL-1_Mouse1.00897812
139BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99850298
140NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99373393
141TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99199338
142ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97955167
143GBX2_23144817_ChIP-Seq_PC3_Human0.97799447
144CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97728814
145FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97509897
146UTX_26944678_Chip-Seq_JUKART_Human0.97487366
147SMC4_20622854_ChIP-Seq_HELA_Human0.96540756
148WDR5_24793694_ChIP-Seq_LNCAP_Human0.95815254
149XRN2_22483619_ChIP-Seq_HELA_Human0.95560041
150PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95489413
151AHR_22903824_ChIP-Seq_MCF-7_Human0.94779412
152THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94495238
153WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94452479
154* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.94049087
155TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93840999
156ELF1_20517297_ChIP-Seq_JURKAT_Human0.92697107
157IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92072411
158CBP_20019798_ChIP-Seq_JUKART_Human0.92072411
159* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91934940
160PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90300689
161GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89509534
162CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88809190
163NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88289591
164SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88066671
165* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87413996
166P68_20966046_ChIP-Seq_HELA_Human0.86480883
167BCOR_27268052_Chip-Seq_Bcells_Human0.85439189
168AR_19668381_ChIP-Seq_PC3_Human0.85347546
169PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84602828
170KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.84046991
171CTBP1_25329375_ChIP-Seq_LNCAP_Human0.83916126
172* ARNT_22903824_ChIP-Seq_MCF-7_Human0.83777181
173EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83265757
174* TP63_22573176_ChIP-Seq_HFKS_Human0.83211475
175SMAD4_21741376_ChIP-Seq_HESCs_Human0.81819720
176GF1_26923725_Chip-Seq_HPCs_Mouse0.81466867
177MYC_27129775_Chip-Seq_CORNEA_Mouse0.80398887
178PRDM14_20953172_ChIP-Seq_ESCs_Human0.80161601

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.61590215
2MP0004859_abnormal_synaptic_plasticity6.23166441
3MP0003705_abnormal_hypodermis_morpholog4.46826888
4MP0003635_abnormal_synaptic_transmissio3.46583507
5MP0003880_abnormal_central_pattern3.36469451
6MP0002877_abnormal_melanocyte_morpholog3.25985497
7MP0003566_abnormal_cell_adhesion2.89872444
8MP0005451_abnormal_body_composition2.86423322
9MP0004270_analgesia2.79460721
10MP0000751_myopathy2.79021391
11MP0005423_abnormal_somatic_nervous2.42900232
12MP0002064_seizures2.42508074
13MP0008260_abnormal_autophagy2.42360206
14MP0004147_increased_porphyrin_level2.42163985
15MP0003698_abnormal_male_reproductive2.40581513
16MP0001968_abnormal_touch/_nociception2.39008703
17MP0002063_abnormal_learning/memory/cond2.37285435
18MP0008438_abnormal_cutaneous_collagen2.32801684
19MP0009046_muscle_twitch2.32000416
20MP0009745_abnormal_behavioral_response2.24104582
21MP0005083_abnormal_biliary_tract2.11943156
22MP0009278_abnormal_bone_marrow2.06912478
23MP0004858_abnormal_nervous_system2.03267141
24MP0002734_abnormal_mechanical_nocicepti1.99978571
25MP0003329_amyloid_beta_deposits1.97736907
26MP0001849_ear_inflammation1.96819548
27MP0002837_dystrophic_cardiac_calcinosis1.93608358
28MP0009780_abnormal_chondrocyte_physiolo1.92742598
29MP0005623_abnormal_meninges_morphology1.86888601
30MP0000678_abnormal_parathyroid_gland1.86732583
31MP0002572_abnormal_emotion/affect_behav1.85500634
32MP0005076_abnormal_cell_differentiation1.85235020
33MP0002736_abnormal_nociception_after1.84483379
34MP0003646_muscle_fatigue1.83701404
35MP0002272_abnormal_nervous_system1.80910787
36MP0002733_abnormal_thermal_nociception1.78609795
37MP0008569_lethality_at_weaning1.76096162
38MP0001970_abnormal_pain_threshold1.75939217
39MP0003221_abnormal_cardiomyocyte_apopto1.74212948
40MP0004084_abnormal_cardiac_muscle1.72772003
41MP0002638_abnormal_pupillary_reflex1.71693837
42MP0004811_abnormal_neuron_physiology1.67597270
43MP0004510_myositis1.60829260
44MP0001929_abnormal_gametogenesis1.59952392
45MP0004272_abnormal_basement_membrane1.58133825
46MP0002735_abnormal_chemical_nociception1.57960017
47MP0001440_abnormal_grooming_behavior1.54669758
48MP0005058_abnormal_lysosome_morphology1.54564643
49MP0005551_abnormal_eye_electrophysiolog1.53748655
50MP0001486_abnormal_startle_reflex1.53680751
51MP0003453_abnormal_keratinocyte_physiol1.52999963
52MP0001730_embryonic_growth_arrest1.51732368
53MP0005409_darkened_coat_color1.50563835
54MP0002067_abnormal_sensory_capabilities1.48680018
55MP0008961_abnormal_basal_metabolism1.47868335
56MP0002796_impaired_skin_barrier1.47097185
57MP0000579_abnormal_nail_morphology1.44225234
58MP0004215_abnormal_myocardial_fiber1.44145681
59MP0002909_abnormal_adrenal_gland1.41157013
60MP0004233_abnormal_muscle_weight1.39965929
61MP0010630_abnormal_cardiac_muscle1.38808212
62MP0003091_abnormal_cell_migration1.37626146
63MP0003111_abnormal_nucleus_morphology1.37451665
64MP0010234_abnormal_vibrissa_follicle1.36864042
65MP0000749_muscle_degeneration1.35750716
66MP0004036_abnormal_muscle_relaxation1.34746390
67MP0002653_abnormal_ependyma_morphology1.33531350
68MP0005501_abnormal_skin_physiology1.32238911
69MP0000569_abnormal_digit_pigmentation1.31327042
70MP0001545_abnormal_hematopoietic_system1.28605145
71MP0005397_hematopoietic_system_phenotyp1.28605145
72MP0002882_abnormal_neuron_morphology1.27264244
73MP0003633_abnormal_nervous_system1.27052640
74* MP0002161_abnormal_fertility/fecundity1.25759448
75MP0000955_abnormal_spinal_cord1.25123371
76MP0003879_abnormal_hair_cell1.23336784
77MP0009672_abnormal_birth_weight1.21407090
78MP0004947_skin_inflammation1.21330061
79MP0002822_catalepsy1.21195302
80MP0004885_abnormal_endolymph1.18208845
81MP0000750_abnormal_muscle_regeneration1.18120095
82MP0010352_gastrointestinal_tract_polyps1.17312138
83MP0004085_abnormal_heartbeat1.15343882
84MP0004924_abnormal_behavior1.15073613
85MP0005386_behavior/neurological_phenoty1.15073613
86MP0001501_abnormal_sleep_pattern1.14992984
87MP0004185_abnormal_adipocyte_glucose1.13621076
88MP0005464_abnormal_platelet_physiology1.13158455
89MP0002080_prenatal_lethality1.11510002
90MP0002184_abnormal_innervation1.11415384
91MP0005275_abnormal_skin_tensile1.10800233
92MP0005621_abnormal_cell_physiology1.10185477
93MP0003656_abnormal_erythrocyte_physiolo1.09436884
94MP0003941_abnormal_skin_development1.09331766
95MP0000858_altered_metastatic_potential1.09193702
96MP0000537_abnormal_urethra_morphology1.08975390
97MP0002066_abnormal_motor_capabilities/c1.08116691
98MP0001293_anophthalmia1.07599809
99MP0004957_abnormal_blastocyst_morpholog1.07232340
100MP0002557_abnormal_social/conspecific_i1.05832889
101MP0008775_abnormal_heart_ventricle1.04279823
102MP0002229_neurodegeneration1.03227794
103MP0006138_congestive_heart_failure1.02673875
104MP0003283_abnormal_digestive_organ1.01940512
105MP0008932_abnormal_embryonic_tissue1.01812749
106MP0002332_abnormal_exercise_endurance1.01408230
107MP0002060_abnormal_skin_morphology0.99850442
108MP0000350_abnormal_cell_proliferation0.98828124
109MP0004087_abnormal_muscle_fiber0.98249112
110MP0003191_abnormal_cellular_cholesterol0.94369512
111MP0005380_embryogenesis_phenotype0.94042575
112MP0001672_abnormal_embryogenesis/_devel0.94042575
113MP0003984_embryonic_growth_retardation0.93990175
114MP0003631_nervous_system_phenotype0.93810121
115MP0001299_abnormal_eye_distance/0.93533276
116MP0003828_pulmonary_edema0.93149619
117MP0003045_fibrosis0.92838959
118MP0003137_abnormal_impulse_conducting0.92134494
119MP0004130_abnormal_muscle_cell0.92045652
120MP0002152_abnormal_brain_morphology0.91645848
121MP0002234_abnormal_pharynx_morphology0.91405363
122MP0003279_aneurysm0.91253529
123MP0002086_abnormal_extraembryonic_tissu0.91099706
124MP0000013_abnormal_adipose_tissue0.89507137
125MP0002088_abnormal_embryonic_growth/wei0.87735584
126MP0002972_abnormal_cardiac_muscle0.87044283
127MP0005384_cellular_phenotype0.86664474
128MP0003634_abnormal_glial_cell0.85542268
129MP0000604_amyloidosis0.85479209
130MP0000747_muscle_weakness0.84274221
131MP0009840_abnormal_foam_cell0.83530371
132MP0004808_abnormal_hematopoietic_stem0.82703225
133MP0000778_abnormal_nervous_system0.82525558
134MP0005620_abnormal_muscle_contractility0.82514065
135MP0004145_abnormal_muscle_electrophysio0.82329962
136MP0003172_abnormal_lysosome_physiology0.80503787
137MP0000343_altered_response_to0.80106783
138MP0004484_altered_response_of0.79487164
139MP0001727_abnormal_embryo_implantation0.79087042
140MP0003303_peritoneal_inflammation0.79062636
141* MP0009931_abnormal_skin_appearance0.78460531
142MP0008874_decreased_physiological_sensi0.77911462
143MP0001984_abnormal_olfaction0.76990930
144MP0003300_gastrointestinal_ulcer0.76787407
145MP0002106_abnormal_muscle_physiology0.76420466
146MP0001697_abnormal_embryo_size0.76258040
147MP0006276_abnormal_autonomic_nervous0.75784750
148MP0008877_abnormal_DNA_methylation0.74788475
149MP0000313_abnormal_cell_death0.74528211
150MP0005253_abnormal_eye_physiology0.73954020
151MP0003942_abnormal_urinary_system0.73779141
152MP0005666_abnormal_adipose_tissue0.72743844
153MP0001348_abnormal_lacrimal_gland0.71220894
154MP0000759_abnormal_skeletal_muscle0.70831335
155MP0001915_intracranial_hemorrhage0.70199990
156MP0005330_cardiomyopathy0.70031875
157MP0002269_muscular_atrophy0.69822326
158MP0002282_abnormal_trachea_morphology0.69810468
159MP0000733_abnormal_muscle_development0.69576645
160MP0001958_emphysema0.68602634
161MP0005670_abnormal_white_adipose0.68489350
162MP0002210_abnormal_sex_determination0.68301200
163MP0000358_abnormal_cell_content/0.67975727
164MP0000467_abnormal_esophagus_morphology0.67514061
165MP0002752_abnormal_somatic_nervous0.67402088
166MP0001765_abnormal_ion_homeostasis0.67088316
167MP0005385_cardiovascular_system_phenoty0.66941283
168MP0001544_abnormal_cardiovascular_syste0.66941283
169MP0005535_abnormal_body_temperature0.66079469
170MP0005167_abnormal_blood-brain_barrier0.65820492

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)5.57107816
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.57107816
3Bilateral microphthalmos (HP:0007633)4.71858181
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.64059224
5Morphological abnormality of the middle ear (HP:0008609)4.59003860
6Absent eyebrow (HP:0002223)4.56942790
7Myokymia (HP:0002411)4.25715368
8Absent eyelashes (HP:0000561)4.16491474
9* Reticulocytosis (HP:0001923)3.70730879
10Dysmetric saccades (HP:0000641)3.66053426
11Cutaneous finger syndactyly (HP:0010554)3.63394885
12Distal lower limb amyotrophy (HP:0008944)3.53266803
13Progressive cerebellar ataxia (HP:0002073)3.43942824
14Action tremor (HP:0002345)3.43747128
15Bifid tongue (HP:0010297)3.40922414
16Increased connective tissue (HP:0009025)3.36871249
17Midline defect of the nose (HP:0004122)3.36104761
18Centrally nucleated skeletal muscle fibers (HP:0003687)3.36024704
19Abnormal respiratory motile cilium physiology (HP:0012261)3.30512800
20Abnormal respiratory motile cilium morphology (HP:0005938)3.27877922
21Abnormal respiratory epithelium morphology (HP:0012253)3.27877922
22Lower limb amyotrophy (HP:0007210)3.27508126
23* Abnormal gallbladder physiology (HP:0012438)3.25484065
24* Cholecystitis (HP:0001082)3.25484065
25Aplasia/Hypoplasia of the sternum (HP:0006714)3.22732973
26Depression (HP:0000716)3.21477706
27Popliteal pterygium (HP:0009756)3.15612843
28Visual hallucinations (HP:0002367)3.15527634
29Abnormality of the pubic bones (HP:0003172)3.08271422
30Focal seizures (HP:0007359)3.02264736
31Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.01633280
32Choanal stenosis (HP:0000452)3.00637793
33Cortical dysplasia (HP:0002539)2.99623888
34Cutaneous syndactyly (HP:0012725)2.98052729
35Polycythemia (HP:0001901)2.96282490
36Infertility (HP:0000789)2.94598107
37Upper limb amyotrophy (HP:0009129)2.93722347
38Distal upper limb amyotrophy (HP:0007149)2.93722347
39Bicornuate uterus (HP:0000813)2.92090846
40Distal lower limb muscle weakness (HP:0009053)2.91541748
41Supranuclear gaze palsy (HP:0000605)2.89491977
42Ankyloglossia (HP:0010296)2.87276600
43Nasal polyposis (HP:0100582)2.84505293
44Global brain atrophy (HP:0002283)2.83411958
45Truncus arteriosus (HP:0001660)2.75218568
46Focal motor seizures (HP:0011153)2.74384812
47Premature rupture of membranes (HP:0001788)2.74237425
48Insidious onset (HP:0003587)2.73110032
49Termporal pattern (HP:0011008)2.73110032
50Abnormality of the heme biosynthetic pathway (HP:0010472)2.72336533
51Bowel incontinence (HP:0002607)2.66875412
52Rhinitis (HP:0012384)2.66007174
53Facial cleft (HP:0002006)2.64626458
54Insomnia (HP:0100785)2.62838179
55Bundle branch block (HP:0011710)2.61094046
56Hammertoe (HP:0001765)2.58174705
57Hand muscle atrophy (HP:0009130)2.57374461
58Decreased muscle mass (HP:0003199)2.56423579
59Abnormal large intestine physiology (HP:0012700)2.56083877
60Myelomeningocele (HP:0002475)2.51813842
61Rapidly progressive (HP:0003678)2.50390936
62Upper limb muscle weakness (HP:0003484)2.49987920
63Protrusio acetabuli (HP:0003179)2.49450980
64Abnormality of the nasal mucosa (HP:0000433)2.47676533
65Sudden death (HP:0001699)2.47450118
66Abnormal ciliary motility (HP:0012262)2.44407331
67Abnormality of the lower motor neuron (HP:0002366)2.44337012
68Abnormality of skeletal muscle fiber size (HP:0012084)2.42368700
69Abnormality of oral frenula (HP:0000190)2.40196538
70Increased variability in muscle fiber diameter (HP:0003557)2.39909345
71Bradykinesia (HP:0002067)2.35232266
72Impaired smooth pursuit (HP:0007772)2.34573558
73Distal arthrogryposis (HP:0005684)2.34372155
74Aplasia/Hypoplasia of the brainstem (HP:0007362)2.33267286
75Hypoplasia of the brainstem (HP:0002365)2.33267286
76Genetic anticipation (HP:0003743)2.29850022
77Spinal rigidity (HP:0003306)2.29252182
78Gaze-evoked nystagmus (HP:0000640)2.29129101
79Epileptic encephalopathy (HP:0200134)2.28062508
80Disproportionate tall stature (HP:0001519)2.27134651
81Achilles tendon contracture (HP:0001771)2.27063248
82Abnormality of ocular smooth pursuit (HP:0000617)2.26655883
83Anophthalmia (HP:0000528)2.25500765
84Pointed chin (HP:0000307)2.25143764
85Abnormality of nail color (HP:0100643)2.25043883
86Postural instability (HP:0002172)2.24393099
87Ventricular fibrillation (HP:0001663)2.24009724
88Foot dorsiflexor weakness (HP:0009027)2.23480215
89Chronic bronchitis (HP:0004469)2.22718026
90Acanthocytosis (HP:0001927)2.22073605
91Male infertility (HP:0003251)2.21552374
92Urinary bladder sphincter dysfunction (HP:0002839)2.20549848
93Abnormality of the lacrimal duct (HP:0011481)2.20091815
94Dysdiadochokinesis (HP:0002075)2.20060632
95Chin dimple (HP:0010751)2.20001882
96Hyperkalemia (HP:0002153)2.17855797
97Omphalocele (HP:0001539)2.16598417
98* Abnormality of reticulocytes (HP:0004312)2.16464040
99Akinesia (HP:0002304)2.16049879
100Long palpebral fissure (HP:0000637)2.14440322
101Choroideremia (HP:0001139)2.13597229
102Hemiparesis (HP:0001269)2.12278915
103Distal sensory impairment (HP:0002936)2.10415447
104Obstructive sleep apnea (HP:0002870)2.09441344
105Submucous cleft hard palate (HP:0000176)2.09374729
106Cerebral inclusion bodies (HP:0100314)2.09179607
107Tracheal stenosis (HP:0002777)2.09011726
108Hyperthyroidism (HP:0000836)2.08293868
109Skull defect (HP:0001362)2.07934744
110Abnormality of the tricuspid valve (HP:0001702)2.07152169
111Poikilocytosis (HP:0004447)2.06920216
112* Abnormal gallbladder morphology (HP:0012437)2.06915684
113Truncal ataxia (HP:0002078)2.05931510
114Ankle clonus (HP:0011448)2.05854794
115Abnormality of the foot musculature (HP:0001436)2.05503240
116Myopathic facies (HP:0002058)2.01500848
117Cerebral aneurysm (HP:0004944)2.00875858
118Central scotoma (HP:0000603)2.00532202
119Mutism (HP:0002300)2.00420225
120Patellar dislocation (HP:0002999)1.99931617
121Neurofibrillary tangles (HP:0002185)1.99810426
122Hyporeflexia of lower limbs (HP:0002600)1.99338259
123Abnormality of binocular vision (HP:0011514)1.97982295
124Diplopia (HP:0000651)1.97982295
125Absent hair (HP:0002298)1.97288850
126Renal hypoplasia (HP:0000089)1.96078404
127Exercise-induced myalgia (HP:0003738)1.95727890
128Mildly elevated creatine phosphokinase (HP:0008180)1.94655316
129Difficulty climbing stairs (HP:0003551)1.94532763
130Neuronal loss in central nervous system (HP:0002529)1.94290774
131Thoracolumbar scoliosis (HP:0002944)1.94121270
132Papilledema (HP:0001085)1.93317626
133Diaphragmatic weakness (HP:0009113)1.92308823
134Hypertensive crisis (HP:0100735)1.92220909
135Atelectasis (HP:0100750)1.92158289
136Vaginal atresia (HP:0000148)1.92133902
137Asymmetric septal hypertrophy (HP:0001670)1.91359272
138Hyperacusis (HP:0010780)1.91131464
139Atonic seizures (HP:0010819)1.90954266
140Flat cornea (HP:0007720)1.90902012
141Wide intermamillary distance (HP:0006610)1.89048418
142Type 1 muscle fiber predominance (HP:0003803)1.88834182
143Amblyopia (HP:0000646)1.88757079
144* Decreased motor nerve conduction velocity (HP:0003431)1.87090979
145* Cholelithiasis (HP:0001081)1.84464508
146Back pain (HP:0003418)1.84089299
147Bladder diverticulum (HP:0000015)1.83938931
148Broad distal phalanx of finger (HP:0009836)1.83911300
149Overlapping toe (HP:0001845)1.83841653
150Genital tract atresia (HP:0001827)1.83763797
151Abnormality of the nasolacrimal system (HP:0000614)1.83394780
152Primary atrial arrhythmia (HP:0001692)1.82320049
153Down-sloping shoulders (HP:0200021)1.81897001
154Dysmetria (HP:0001310)1.81687503
155Apathy (HP:0000741)1.81653633
156Urinary urgency (HP:0000012)1.81383201
157Abnormality of the Achilles tendon (HP:0005109)1.81332101
158Muscle fiber splitting (HP:0003555)1.78911715
159Slow saccadic eye movements (HP:0000514)1.78197248
160Overriding aorta (HP:0002623)1.78076674
161Hypoparathyroidism (HP:0000829)1.73184430
162Nonimmune hydrops fetalis (HP:0001790)1.72826458
163* Abnormality of the gallbladder (HP:0005264)1.72826298
164Atrophic scars (HP:0001075)1.72527203
165Dilatation of the ascending aorta (HP:0005111)1.72478162
166Pelvic girdle muscle weakness (HP:0003749)1.72332657
167Fragile skin (HP:0001030)1.71090655
168Orthostatic hypotension (HP:0001278)1.70895338
169Breech presentation (HP:0001623)1.70077557
170Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.69465329
171Shallow orbits (HP:0000586)1.68795475
172Segmental peripheral demyelination/remyelination (HP:0003481)1.68020083
173Arterial tortuosity (HP:0005116)1.66065667
174Vertebral compression fractures (HP:0002953)1.64779074
175Scapular winging (HP:0003691)1.63979148
176Shoulder girdle muscle weakness (HP:0003547)1.60612696
177Ragged-red muscle fibers (HP:0003200)1.59547189
178Diminished motivation (HP:0000745)1.58144698
179Ulnar bowing (HP:0003031)1.57924228
180Abnormality of the salivary glands (HP:0010286)1.57250169
181Relative macrocephaly (HP:0004482)1.56031400
182EMG: neuropathic changes (HP:0003445)1.54802817
183Vascular tortuosity (HP:0004948)1.54681299
184Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.54413600
185Wormian bones (HP:0002645)1.53819681
186Gastrointestinal dysmotility (HP:0002579)1.53683133

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK14.83292382
2PTK2B4.64088138
3PRKD33.69988225
4PRPF4B3.36762228
5PDK43.24080454
6PDK33.24080454
7TLK13.00916283
8KSR22.69847406
9BLK2.68726485
10TESK22.64311441
11CDK122.36660530
12ICK2.10782398
13MAP3K22.07541369
14SMG12.06923898
15EIF2AK11.95522640
16TRIB31.86954852
17MARK11.85858839
18MAP3K91.85609712
19ARAF1.83126628
20MINK11.80789327
21NTRK31.79358537
22PAK61.69855986
23PDK21.69115200
24TAOK21.66556907
25STK381.66343650
26IRAK31.64914187
27PNCK1.61697432
28LIMK11.61356819
29KSR11.58292622
30MAP3K41.57809572
31LMTK21.57075612
32CAMKK11.56634709
33PKN21.54489970
34SIK21.51551395
35CLK11.44679584
36RAF11.43397008
37PDGFRA1.42737093
38RET1.42034131
39WNK41.37463528
40DAPK21.34314145
41SIK11.33379811
42EPHA41.32958090
43EEF2K1.21028331
44MAP3K81.18858979
45WNK11.18318199
46PINK11.16333699
47PHKG11.13226338
48PHKG21.13226338
49STK391.12339898
50MAP3K131.05934561
51NTRK21.05789490
52GRK51.03826121
53BRAF1.03356561
54MAP3K61.03300981
55MTOR1.02987168
56MAP3K11.02407651
57UHMK10.99640504
58PAK40.99338500
59NTRK10.99168475
60MOS0.96890855
61FGFR40.93643518
62FES0.92969016
63CDK50.91612292
64RIPK40.88280501
65PTK20.87154640
66PDK10.86259248
67MAP2K70.84996151
68MAP2K30.84550655
69MAP3K100.83480302
70TTK0.81987706
71MAP3K70.81124078
72MAP4K10.80037274
73MARK20.78959439
74TSSK60.76839425
75TYRO30.75557163
76CAMK10.74703456
77RIPK10.73174225
78MAP2K40.71721299
79ALK0.70974722
80ERN10.68070183
81PAK10.67191643
82DMPK0.66465934
83CDK150.65022609
84PLK20.63516036
85PAK30.62925229
86CDC42BPA0.62782178
87PDPK10.61089682
88TTN0.61073248
89CDK180.61058616
90CDK140.60742023
91NME20.60668571
92NEK10.60320045
93PRKCH0.60234266
94TAOK10.60043128
95DYRK1B0.59587951
96MAPK100.59121062
97PRKCG0.57826008
98CDK11A0.56010142
99ROCK20.55948418
100MAPK130.54635739
101STK110.52439562
102LATS20.52209098
103CAMK1D0.51953453
104MAPK120.50999818
105CAMK2A0.50844236
106CAMKK20.50124583
107CDK80.49155784
108PRKD10.48903051
109BMX0.48359332
110SGK30.47464780
111SCYL20.47337593
112CAMK1G0.46871828
113SIK30.46829894
114MAP2K10.46714101
115DAPK10.46031746
116PIM20.44031112
117TNK20.43507431
118LRRK20.42982908
119MAP3K30.42386505
120MAPKAPK50.41242689
121RPS6KC10.41158262
122RPS6KL10.41158262
123RPS6KA40.40108278
124MAPKAPK30.39674196
125AKT20.39551991
126TRPM70.39179678
127EPHA30.38325245
128SGK4940.37496757
129SGK2230.37496757
130RPS6KA20.36781167
131STK40.36116691
132RPS6KB20.35613749
133CAMK40.35341136
134CAMK2G0.35160366
135PTK60.34861106
136EPHA20.34026087
137EPHB10.33446342
138BMPR20.33392574
139PRKD20.33110474
140FER0.31427496
141PAK20.30878669
142SRC0.29854312
143SGK20.29549468
144FYN0.28503219
145MAP3K110.28372724
146RPS6KA30.28177126
147DAPK30.26455362
148JAK20.26324900
149ROCK10.25168625

Predicted pathways (KEGG)

RankGene SetZ-score
1Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.08044872
2Synaptic vesicle cycle_Homo sapiens_hsa047212.90577038
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.89399328
4Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.30798512
5Long-term potentiation_Homo sapiens_hsa047202.15675310
6Nicotine addiction_Homo sapiens_hsa050332.09567562
7Cardiac muscle contraction_Homo sapiens_hsa042602.01845890
8Circadian entrainment_Homo sapiens_hsa047131.98773318
9Salivary secretion_Homo sapiens_hsa049701.96497181
10Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.94176532
11Olfactory transduction_Homo sapiens_hsa047401.91362018
12Insulin secretion_Homo sapiens_hsa049111.89944421
13Amphetamine addiction_Homo sapiens_hsa050311.77985263
14Acute myeloid leukemia_Homo sapiens_hsa052211.76086539
15Glutamatergic synapse_Homo sapiens_hsa047241.72193541
16Gastric acid secretion_Homo sapiens_hsa049711.71643443
17Thyroid cancer_Homo sapiens_hsa052161.69654845
18* Carbohydrate digestion and absorption_Homo sapiens_hsa049731.67205529
19Phototransduction_Homo sapiens_hsa047441.64862245
20Dorso-ventral axis formation_Homo sapiens_hsa043201.63393366
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62956148
22GABAergic synapse_Homo sapiens_hsa047271.57871783
23Taste transduction_Homo sapiens_hsa047421.57202527
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.57021431
25Pentose phosphate pathway_Homo sapiens_hsa000301.54224906
26Dopaminergic synapse_Homo sapiens_hsa047281.50580509
27Morphine addiction_Homo sapiens_hsa050321.49458120
28Pancreatic cancer_Homo sapiens_hsa052121.48460189
29Bladder cancer_Homo sapiens_hsa052191.47505716
30Collecting duct acid secretion_Homo sapiens_hsa049661.46343017
31Biosynthesis of amino acids_Homo sapiens_hsa012301.45824599
32Cholinergic synapse_Homo sapiens_hsa047251.41152303
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39282815
34Prion diseases_Homo sapiens_hsa050201.38782033
35Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.38472938
36Renin secretion_Homo sapiens_hsa049241.37938776
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35424361
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31424289
39Adherens junction_Homo sapiens_hsa045201.31376476
40Oxytocin signaling pathway_Homo sapiens_hsa049211.31059179
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.30068369
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.29307082
43Estrogen signaling pathway_Homo sapiens_hsa049151.25791760
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20249678
45Shigellosis_Homo sapiens_hsa051311.19930287
46Focal adhesion_Homo sapiens_hsa045101.17848300
47Glioma_Homo sapiens_hsa052141.17588851
48Calcium signaling pathway_Homo sapiens_hsa040201.16687334
49Oocyte meiosis_Homo sapiens_hsa041141.13344396
50cAMP signaling pathway_Homo sapiens_hsa040241.12925276
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.12757712
52* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10448497
53Fatty acid biosynthesis_Homo sapiens_hsa000611.09732001
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09655050
55Long-term depression_Homo sapiens_hsa047301.09205006
56* Type II diabetes mellitus_Homo sapiens_hsa049301.07317929
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06814030
58Glucagon signaling pathway_Homo sapiens_hsa049221.05564612
59Dilated cardiomyopathy_Homo sapiens_hsa054141.04977005
60Gap junction_Homo sapiens_hsa045401.04745748
61VEGF signaling pathway_Homo sapiens_hsa043701.02361942
62Cocaine addiction_Homo sapiens_hsa050301.00106582
63GnRH signaling pathway_Homo sapiens_hsa049120.99526809
64Endocytosis_Homo sapiens_hsa041440.98121301
65* Carbon metabolism_Homo sapiens_hsa012000.96349151
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95709645
67Proteoglycans in cancer_Homo sapiens_hsa052050.95458653
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.94855771
69MicroRNAs in cancer_Homo sapiens_hsa052060.94820423
70Prolactin signaling pathway_Homo sapiens_hsa049170.94782459
71Thyroid hormone synthesis_Homo sapiens_hsa049180.93675361
72* Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92501787
73* Central carbon metabolism in cancer_Homo sapiens_hsa052300.91966757
74Pancreatic secretion_Homo sapiens_hsa049720.91741425
75Amoebiasis_Homo sapiens_hsa051460.90730910
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.86263733
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85206861
78Bile secretion_Homo sapiens_hsa049760.83793997
79Mineral absorption_Homo sapiens_hsa049780.81737636
80Apoptosis_Homo sapiens_hsa042100.81453387
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.81295203
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.80724804
83Notch signaling pathway_Homo sapiens_hsa043300.80560103
84Other glycan degradation_Homo sapiens_hsa005110.80444727
85Viral carcinogenesis_Homo sapiens_hsa052030.80291264
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79253637
87Hepatitis B_Homo sapiens_hsa051610.78572673
88mRNA surveillance pathway_Homo sapiens_hsa030150.78561185
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77487975
90mTOR signaling pathway_Homo sapiens_hsa041500.77247553
91Axon guidance_Homo sapiens_hsa043600.73518313
92ECM-receptor interaction_Homo sapiens_hsa045120.73137230
93Serotonergic synapse_Homo sapiens_hsa047260.72651546
94Prostate cancer_Homo sapiens_hsa052150.70613743
95ErbB signaling pathway_Homo sapiens_hsa040120.70335580
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68999159
97Platelet activation_Homo sapiens_hsa046110.68808458
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.68221359
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67265384
100Inositol phosphate metabolism_Homo sapiens_hsa005620.67061166
101Small cell lung cancer_Homo sapiens_hsa052220.64546886
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64420281
103Melanogenesis_Homo sapiens_hsa049160.64146457
104Endometrial cancer_Homo sapiens_hsa052130.63538889
105* HIF-1 signaling pathway_Homo sapiens_hsa040660.63471209
106Tight junction_Homo sapiens_hsa045300.63333300
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63109699
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62875741
109Non-small cell lung cancer_Homo sapiens_hsa052230.61069172
110Malaria_Homo sapiens_hsa051440.60447709
111MAPK signaling pathway_Homo sapiens_hsa040100.60049548
112* Insulin signaling pathway_Homo sapiens_hsa049100.59744275
113Renal cell carcinoma_Homo sapiens_hsa052110.59591309
114Cell cycle_Homo sapiens_hsa041100.58585717
115Hepatitis C_Homo sapiens_hsa051600.56057585
116Choline metabolism in cancer_Homo sapiens_hsa052310.55789202
117* Fructose and mannose metabolism_Homo sapiens_hsa000510.55391712
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55208369
119Osteoclast differentiation_Homo sapiens_hsa043800.54840656
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54700476
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52007902
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51516563
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50985701
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50711826
125Rap1 signaling pathway_Homo sapiens_hsa040150.48570038
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.47863402
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47226573
128Salmonella infection_Homo sapiens_hsa051320.44676351
129Vibrio cholerae infection_Homo sapiens_hsa051100.43892467
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40133271
131Glycerolipid metabolism_Homo sapiens_hsa005610.39720941
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.39435240
133Chronic myeloid leukemia_Homo sapiens_hsa052200.37698933
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.37617957
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37371466
136B cell receptor signaling pathway_Homo sapiens_hsa046620.36240494
137Colorectal cancer_Homo sapiens_hsa052100.35490480
138Alcoholism_Homo sapiens_hsa050340.35395687
139AMPK signaling pathway_Homo sapiens_hsa041520.34501338
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33943064

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