HK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)5.31167012
2muscle filament sliding (GO:0030049)5.31167012
3low-density lipoprotein particle clearance (GO:0034383)5.14101187
4sarcomere organization (GO:0045214)5.04500124
5actin-mediated cell contraction (GO:0070252)4.50443037
6nuclear pore complex assembly (GO:0051292)4.43291794
7cardiac myofibril assembly (GO:0055003)4.42946831
8myofibril assembly (GO:0030239)4.36606910
9nuclear pore organization (GO:0006999)4.27066472
10skin morphogenesis (GO:0043589)3.97065473
11heart contraction (GO:0060047)3.88390647
12heart process (GO:0003015)3.88390647
13response to peptidoglycan (GO:0032494)3.86929744
14peptidyl-proline hydroxylation (GO:0019511)3.80881600
15regulation of vitamin D biosynthetic process (GO:0060556)3.80736355
16cardiac muscle tissue morphogenesis (GO:0055008)3.76068437
17positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.75886526
18IMP biosynthetic process (GO:0006188)3.69837833
19regulation of cholesterol storage (GO:0010885)3.68213893
20regulation of skeletal muscle contraction (GO:0014819)3.65614638
21cardiac muscle cell development (GO:0055013)3.63908605
22cardiac cell development (GO:0055006)3.61020186
23pore complex assembly (GO:0046931)3.59429266
24oligosaccharide catabolic process (GO:0009313)3.55491767
25keratinization (GO:0031424)3.55177699
26regulation of posttranscriptional gene silencing (GO:0060147)3.52024101
27regulation of gene silencing by miRNA (GO:0060964)3.52024101
28regulation of gene silencing by RNA (GO:0060966)3.52024101
29glycosphingolipid catabolic process (GO:0046479)3.49074812
30IMP metabolic process (GO:0046040)3.41454070
31actin filament-based movement (GO:0030048)3.39132608
32muscle tissue morphogenesis (GO:0060415)3.39074407
33regulation of cholesterol homeostasis (GO:2000188)3.38364217
34regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.35077770
35pinocytosis (GO:0006907)3.30585564
36ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.29329123
37protein hydroxylation (GO:0018126)3.27524167
38regulation of vitamin metabolic process (GO:0030656)3.26159577
394-hydroxyproline metabolic process (GO:0019471)3.26085848
40paraxial mesoderm development (GO:0048339)3.25707849
41actomyosin structure organization (GO:0031032)3.23869481
42protein localization to endosome (GO:0036010)3.21589891
43detection of other organism (GO:0098543)3.20267983
44cardiac muscle contraction (GO:0060048)3.15891239
45T-helper 1 type immune response (GO:0042088)3.15789347
46positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.12802276
47surfactant homeostasis (GO:0043129)3.09416240
48detection of bacterium (GO:0016045)3.08331839
49epithelial cell differentiation involved in prostate gland development (GO:0060742)3.07831307
50response to muramyl dipeptide (GO:0032495)3.05828788
51osteoclast differentiation (GO:0030316)3.04025826
52glycolipid catabolic process (GO:0019377)3.03795486
53response to laminar fluid shear stress (GO:0034616)3.02173467
54regulation of membrane protein ectodomain proteolysis (GO:0051043)2.98292117
55linoleic acid metabolic process (GO:0043651)2.97333778
56lipopolysaccharide-mediated signaling pathway (GO:0031663)2.95249084
57alpha-linolenic acid metabolic process (GO:0036109)2.94526551
58negative regulation of interleukin-12 production (GO:0032695)2.94521072
59negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.92592509
60regulation of podosome assembly (GO:0071801)2.91112139
61histone H3-K9 demethylation (GO:0033169)2.87793166
62cardiac muscle hypertrophy (GO:0003300)2.87197914
63bundle of His cell to Purkinje myocyte communication (GO:0086069)2.86710707
64regulation of relaxation of muscle (GO:1901077)2.84707454
65* glycolytic process (GO:0006096)2.84333336
66negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.83908884
67decidualization (GO:0046697)2.83289059
68negative regulation of striated muscle cell apoptotic process (GO:0010664)2.83071819
69fructose metabolic process (GO:0006000)2.82203834
70regulation of cardioblast differentiation (GO:0051890)2.80777831
71modulation by symbiont of host defense response (GO:0052031)2.79295726
72modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.79295726
73modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.79295726
74positive regulation by organism of defense response of other organism involved in symbiotic interact2.79295726
75modulation by symbiont of host immune response (GO:0052553)2.79295726
76positive regulation by symbiont of host defense response (GO:0052509)2.79295726
77negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.78520057
78positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.77445073
79striated muscle contraction (GO:0006941)2.77159147
80barbed-end actin filament capping (GO:0051016)2.76542790
81positive regulation of SMAD protein import into nucleus (GO:0060391)2.74644816
82positive regulation of cellular amide metabolic process (GO:0034250)2.74618227
83mitotic nuclear envelope disassembly (GO:0007077)2.74168125
84striated muscle hypertrophy (GO:0014897)2.73804034
85regulation of NFAT protein import into nucleus (GO:0051532)2.72615021
86negative regulation of fatty acid biosynthetic process (GO:0045717)2.72214694
87apoptotic cell clearance (GO:0043277)2.71115631
88negative regulation of myeloid cell apoptotic process (GO:0033033)2.69712108
89detection of external biotic stimulus (GO:0098581)2.69698109
90adult heart development (GO:0007512)2.68841004
91plasma membrane repair (GO:0001778)2.67125574
92oxidative phosphorylation (GO:0006119)2.66159083
93muscle hypertrophy (GO:0014896)2.65469169
94detection of molecule of bacterial origin (GO:0032490)2.65175383
95regulation of fever generation (GO:0031620)2.63545669
96nodal signaling pathway (GO:0038092)2.63087848
97plasma lipoprotein particle clearance (GO:0034381)2.62442674
98ventricular cardiac muscle cell development (GO:0055015)2.62010802
99positive regulation of cholesterol efflux (GO:0010875)2.61297505
100response to lipoprotein particle (GO:0055094)2.59809550
101positive regulation of chemokine biosynthetic process (GO:0045080)2.58875025
102regulation of heterotypic cell-cell adhesion (GO:0034114)2.57625941
103branching involved in labyrinthine layer morphogenesis (GO:0060670)2.57395190
104nuclear envelope disassembly (GO:0051081)2.57112923
105membrane disassembly (GO:0030397)2.57112923
106macrophage activation involved in immune response (GO:0002281)2.56335409
107Golgi transport vesicle coating (GO:0048200)2.55336719
108COPI coating of Golgi vesicle (GO:0048205)2.55336719
109cellular response to zinc ion (GO:0071294)2.55217954
110cellular response to arsenic-containing substance (GO:0071243)2.54560676
111ceramide catabolic process (GO:0046514)2.52425578
112germinal center formation (GO:0002467)2.51385291
113regulation of T-helper 2 cell differentiation (GO:0045628)2.49802369
114regulation of actin filament-based movement (GO:1903115)2.48933965
115regulation of cytokine secretion involved in immune response (GO:0002739)2.48361614
116regulation of early endosome to late endosome transport (GO:2000641)2.48104662
117peptide catabolic process (GO:0043171)2.46672201
118detection of biotic stimulus (GO:0009595)2.44937123
119myeloid dendritic cell differentiation (GO:0043011)2.44857685
120protein-lipid complex assembly (GO:0065005)2.44082709
121keratinocyte differentiation (GO:0030216)2.43442504
122cellular response to thyroid hormone stimulus (GO:0097067)2.42582549
123regulation of SMAD protein import into nucleus (GO:0060390)2.42502156
124positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.42136973
125* glucose 6-phosphate metabolic process (GO:0051156)2.41910766
126NIK/NF-kappaB signaling (GO:0038061)2.41891431
127positive regulation of extracellular matrix organization (GO:1903055)2.40821000
128negative regulation by host of viral transcription (GO:0043922)2.40687124
129maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.39174466
130dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.38850365
131regulation of striated muscle cell apoptotic process (GO:0010662)2.38079527
132skeletal muscle adaptation (GO:0043501)2.36877057
133positive regulation of Cdc42 GTPase activity (GO:0043089)2.36804132
134macrophage differentiation (GO:0030225)2.35189494
135plasma lipoprotein particle assembly (GO:0034377)2.34323275
136regulation of water loss via skin (GO:0033561)2.33362761
137wound healing, spreading of epidermal cells (GO:0035313)2.33165765
138daunorubicin metabolic process (GO:0044597)2.32150213
139polyketide metabolic process (GO:0030638)2.32150213
140doxorubicin metabolic process (GO:0044598)2.32150213
141RNA stabilization (GO:0043489)2.30332133
142mRNA stabilization (GO:0048255)2.30332133
143apoptotic process involved in morphogenesis (GO:0060561)2.29777462
144negative regulation of potassium ion transmembrane transport (GO:1901380)2.29719823
145regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.28882376
146fibroblast migration (GO:0010761)2.28681044
147ER-nucleus signaling pathway (GO:0006984)2.27790934
148activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.25930100
149cell adhesion mediated by integrin (GO:0033627)2.25646617
150endothelial cell chemotaxis (GO:0035767)2.25628405
151hypotonic response (GO:0006971)2.25485674
152skeletal muscle tissue regeneration (GO:0043403)2.25368012
153protein K6-linked ubiquitination (GO:0085020)2.25188439
154regulation of integrin activation (GO:0033623)2.24882085
155hyaluronan metabolic process (GO:0030212)2.23699593
156sexual reproduction (GO:0019953)2.23667044
157metaphase plate congression (GO:0051310)2.23126112
158positive regulation of heat generation (GO:0031652)2.22500332
159negative regulation of skeletal muscle tissue development (GO:0048642)2.21981148
160positive regulation of gamma-delta T cell activation (GO:0046645)2.21861329
161mitotic metaphase plate congression (GO:0007080)2.21747913
162histone lysine demethylation (GO:0070076)2.21521041
163tricarboxylic acid cycle (GO:0006099)2.20561727
164nucleobase biosynthetic process (GO:0046112)2.20502283
165ribosomal small subunit assembly (GO:0000028)2.20071405
166regulation of transforming growth factor beta2 production (GO:0032909)2.19772879
167notochord development (GO:0030903)2.17796468
168positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.15621468
169skeletal muscle contraction (GO:0003009)2.15131798
170antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.13200326
171embryonic process involved in female pregnancy (GO:0060136)2.13127194
172regulation of mitotic spindle organization (GO:0060236)2.12977223
173formation of translation preinitiation complex (GO:0001731)2.12893393
174striated muscle atrophy (GO:0014891)2.12713003
175regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.11437332
176positive regulation of lipid storage (GO:0010884)2.08913753
177positive regulation of protein import into nucleus, translocation (GO:0033160)2.06918543
178epithelial cell-cell adhesion (GO:0090136)2.05801804
1793-UTR-mediated mRNA stabilization (GO:0070935)2.05572231
180negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.05269779
181cellular response to interleukin-6 (GO:0071354)2.04975541
182DNA replication initiation (GO:0006270)2.04088866
183positive regulation of p38MAPK cascade (GO:1900745)2.01225939
184regulation of cardiac muscle cell apoptotic process (GO:0010665)2.00795492
185ventricular trabecula myocardium morphogenesis (GO:0003222)2.00334724
186nuclear envelope organization (GO:0006998)2.00141296
187RNA-dependent DNA replication (GO:0006278)2.00113152
188regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)1.98405568
189mitotic G2 DNA damage checkpoint (GO:0007095)1.97636408
190establishment of chromosome localization (GO:0051303)1.97521584
191regulation of sequestering of triglyceride (GO:0010889)1.97336506
192cardiac right ventricle morphogenesis (GO:0003215)1.97241643
193striated muscle cell development (GO:0055002)1.96267196
194muscle adaptation (GO:0043500)1.95910495
195telomere maintenance via semi-conservative replication (GO:0032201)1.95545361

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.18071647
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.00661661
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.26650382
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.18849527
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.83707211
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.64095223
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.34708854
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.23759377
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.23759377
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.23759377
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20880979
12STAT3_1855785_ChIP-Seq_MESCs_Mouse2.18277766
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.15262804
14* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.11250855
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06734385
16* HIF1A_21447827_ChIP-Seq_MCF-7_Human2.06575340
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.05911594
18* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.04780358
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.04283285
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.94111555
21NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93372914
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93114158
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.92812265
24* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.92377910
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.90236249
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89996335
27NANOG_18555785_ChIP-Seq_MESCs_Mouse1.87769056
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.82566913
29* ELK3_25401928_ChIP-Seq_HUVEC_Human1.78913514
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.78742252
31VDR_21846776_ChIP-Seq_THP-1_Human1.77445563
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71708648
33* IRF8_27001747_Chip-Seq_BMDM_Mouse1.71234491
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.71054918
35* TCF7_22412390_ChIP-Seq_EML_Mouse1.69584258
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67635930
37* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66846734
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.66113593
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.63921983
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63056494
41TCF3_18692474_ChIP-Seq_MEFs_Mouse1.58438774
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57717192
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57576580
44CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.57140466
45* RACK7_27058665_Chip-Seq_MCF-7_Human1.53469696
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52646776
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52385582
48* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49702839
49LXR_22292898_ChIP-Seq_THP-1_Human1.49471839
50* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47478293
51FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.47116624
52NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.45843791
53NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.43690926
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43379496
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42848364
56* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.42843153
57ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.42590684
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41846620
59* KDM2B_26808549_Chip-Seq_DND41_Human1.39888040
60VDR_24763502_ChIP-Seq_THP-1_Human1.38607237
61* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37774096
62* KDM2B_26808549_Chip-Seq_K562_Human1.36852166
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.35761857
64* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.35465358
65MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34874551
66KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.34032720
67* UBF1/2_26484160_Chip-Seq_HMECs_Human1.31790294
68* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31508398
69AR_21909140_ChIP-Seq_LNCAP_Human1.31453135
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29423809
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29292341
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29233419
73ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.28888864
74RXR_22158963_ChIP-Seq_LIVER_Mouse1.28160211
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27572533
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27296023
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27296023
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27084114
79* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26835176
80CLOCK_20551151_ChIP-Seq_293T_Human1.26601510
81IRF8_21731497_ChIP-ChIP_J774_Mouse1.26308773
82FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25861810
83SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25574423
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.25086394
85ELK1_19687146_ChIP-ChIP_HELA_Human1.24296506
86* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.22910227
87PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21898827
88GATA1_22025678_ChIP-Seq_K562_Human1.20103359
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.20018261
90LXR_22158963_ChIP-Seq_LIVER_Mouse1.19737933
91* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19085259
92SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18169781
93MYB_21317192_ChIP-Seq_ERMYB_Mouse1.18013544
94NCOR1_26117541_ChIP-Seq_K562_Human1.17990113
95ESR1_21235772_ChIP-Seq_MCF-7_Human1.17732657
96* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17446544
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16930975
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16792438
99VDR_24787735_ChIP-Seq_THP-1_Human1.16370136
100NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16247731
101* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16111537
102SALL1_21062744_ChIP-ChIP_HESCs_Human1.14736810
103SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14580589
104EST1_17652178_ChIP-ChIP_JURKAT_Human1.13688577
105TP63_19390658_ChIP-ChIP_HaCaT_Human1.13464586
106* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13383032
107CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11400977
108MYC_22102868_ChIP-Seq_BL_Human1.10530007
109POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10090633
110CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09752585
111* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09040033
112NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08986507
113MAF_26560356_Chip-Seq_TH1_Human1.08782249
114FOXO3_23340844_ChIP-Seq_DLD1_Human1.08401861
115MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08248318
116TCF3_18692474_ChIP-Seq_MESCs_Mouse1.07576717
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07321987
118TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07222746
119PU_27001747_Chip-Seq_BMDM_Mouse1.06761113
120* RUNX1_27514584_Chip-Seq_MCF-7_Human1.06513160
121XRN2_22483619_ChIP-Seq_HELA_Human1.06273221
122ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06191623
123TRIM28_21343339_ChIP-Seq_HEK293_Human1.06069530
124NANOG_18692474_ChIP-Seq_MEFs_Mouse1.05687254
125P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05676371
126SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05536825
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05024756
128ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04296804
129* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03712147
130STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03404216
131* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03332537
132NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03163945
133STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03143774
134* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02823970
135RUNX1_22412390_ChIP-Seq_EML_Mouse1.02577160
136CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02222454
137PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01855386
138SRF_21415370_ChIP-Seq_HL-1_Mouse1.01807579
139* TBX20_22080862_ChIP-Seq_HEART_Mouse1.01254552
140* TBX20_22328084_ChIP-Seq_HEART_Mouse1.01254552
141* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99166635
142ZNF263_19887448_ChIP-Seq_K562_Human0.99100358
143* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98911599
144KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98362528
145NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96530612
146SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96308273
147ATF3_27146783_Chip-Seq_COLON_Human0.95907449
148TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95504219
149* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95089949
150KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93969299
151PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93363188
152SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.93306116
153TTF2_22483619_ChIP-Seq_HELA_Human0.92855299
154TFEB_21752829_ChIP-Seq_HELA_Human0.92702686
155SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90264165
156VDR_23849224_ChIP-Seq_CD4+_Human0.90178619
157BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89721280
158* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89366168
159* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88946276

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.67129890
2MP0003303_peritoneal_inflammation3.55296845
3MP0004084_abnormal_cardiac_muscle3.41128624
4MP0005451_abnormal_body_composition3.23986682
5MP0005058_abnormal_lysosome_morphology3.17066658
6MP0010234_abnormal_vibrissa_follicle2.95581261
7MP0002796_impaired_skin_barrier2.90927036
8MP0000749_muscle_degeneration2.83536838
9MP0003453_abnormal_keratinocyte_physiol2.57167357
10MP0003191_abnormal_cellular_cholesterol2.44272077
11MP0002139_abnormal_hepatobiliary_system2.18543090
12MP0009840_abnormal_foam_cell2.18380025
13MP0002837_dystrophic_cardiac_calcinosis2.16903424
14MP0005330_cardiomyopathy2.15311057
15MP0003300_gastrointestinal_ulcer2.14984152
16MP0005257_abnormal_intraocular_pressure2.12511925
17MP0004036_abnormal_muscle_relaxation2.08745523
18MP0003566_abnormal_cell_adhesion2.07831503
19MP0004087_abnormal_muscle_fiber2.05325700
20MP0003828_pulmonary_edema2.02627502
21MP0003950_abnormal_plasma_membrane2.00397687
22MP0008775_abnormal_heart_ventricle1.98983609
23MP0010352_gastrointestinal_tract_polyps1.97892853
24MP0002972_abnormal_cardiac_muscle1.97576926
25MP0000751_myopathy1.94943395
26MP0004947_skin_inflammation1.93711195
27MP0000750_abnormal_muscle_regeneration1.92715423
28MP0010630_abnormal_cardiac_muscle1.92581162
29MP0004264_abnormal_extraembryonic_tissu1.92064133
30MP0000604_amyloidosis1.84014501
31MP0003705_abnormal_hypodermis_morpholog1.82585987
32MP0008260_abnormal_autophagy1.82428747
33MP0003172_abnormal_lysosome_physiology1.82187366
34MP0003941_abnormal_skin_development1.78576517
35MP0003567_abnormal_fetal_cardiomyocyte1.74560613
36MP0003329_amyloid_beta_deposits1.73933916
37MP0001544_abnormal_cardiovascular_syste1.72090909
38MP0005385_cardiovascular_system_phenoty1.72090909
39MP0006082_CNS_inflammation1.69802466
40MP0002106_abnormal_muscle_physiology1.65386723
41MP0004215_abnormal_myocardial_fiber1.62384365
42MP0008438_abnormal_cutaneous_collagen1.59323450
43MP0010094_abnormal_chromosome_stability1.59194541
44MP0002877_abnormal_melanocyte_morpholog1.57847416
45MP0002998_abnormal_bone_remodeling1.57068965
46MP0000343_altered_response_to1.55393657
47MP0005501_abnormal_skin_physiology1.54486806
48MP0003221_abnormal_cardiomyocyte_apopto1.53408822
49MP0004510_myositis1.51738860
50MP0005620_abnormal_muscle_contractility1.51561138
51MP0005670_abnormal_white_adipose1.50784233
52MP0002269_muscular_atrophy1.50240312
53MP0005375_adipose_tissue_phenotype1.49154956
54MP0003091_abnormal_cell_migration1.47496154
55MP0005023_abnormal_wound_healing1.46531360
56MP0003724_increased_susceptibility_to1.46426611
57MP0003693_abnormal_embryo_hatching1.46121844
58MP0003077_abnormal_cell_cycle1.43681672
59MP0001216_abnormal_epidermal_layer1.39508788
60MP0005076_abnormal_cell_differentiation1.39006758
61MP0002332_abnormal_exercise_endurance1.38493640
62MP0006138_congestive_heart_failure1.35740768
63MP0003111_abnormal_nucleus_morphology1.33083969
64MP0008057_abnormal_DNA_replication1.32497158
65MP0008007_abnormal_cellular_replicative1.31026141
66MP0010030_abnormal_orbit_morphology1.30746750
67MP0004957_abnormal_blastocyst_morpholog1.28245684
68MP0000759_abnormal_skeletal_muscle1.28162913
69MP0000579_abnormal_nail_morphology1.25844249
70MP0005369_muscle_phenotype1.25025040
71MP0010307_abnormal_tumor_latency1.24421688
72MP0005409_darkened_coat_color1.24115129
73MP0004484_altered_response_of1.22251344
74MP0002127_abnormal_cardiovascular_syste1.22225409
75MP0005025_abnormal_response_to1.21777251
76MP0001533_abnormal_skeleton_physiology1.20339094
77MP0004858_abnormal_nervous_system1.19993221
78* MP0002088_abnormal_embryonic_growth/wei1.17563876
79MP0010678_abnormal_skin_adnexa1.17412914
80* MP0003984_embryonic_growth_retardation1.17363909
81MP0005275_abnormal_skin_tensile1.16600202
82MP0000733_abnormal_muscle_development1.16566682
83MP0005666_abnormal_adipose_tissue1.16370500
84MP0002971_abnormal_brown_adipose1.14472719
85MP0005164_abnormal_response_to1.13854591
86MP0004272_abnormal_basement_membrane1.12721714
87MP0009115_abnormal_fat_cell1.11828341
88MP0003656_abnormal_erythrocyte_physiolo1.10480787
89MP0001790_abnormal_immune_system1.10356553
90MP0005387_immune_system_phenotype1.10356553
91MP0006054_spinal_hemorrhage1.09908896
92MP0005000_abnormal_immune_tolerance1.09808509
93MP0001915_intracranial_hemorrhage1.09225141
94MP0003075_altered_response_to1.08106892
95* MP0005380_embryogenesis_phenotype1.07806301
96* MP0001672_abnormal_embryogenesis/_devel1.07806301
97MP0001545_abnormal_hematopoietic_system1.07692231
98MP0005397_hematopoietic_system_phenotyp1.07692231
99MP0003436_decreased_susceptibility_to1.07670370
100MP0004130_abnormal_muscle_cell1.06133072
101MP0001835_abnormal_antigen_presentation1.04761255
102MP0003123_paternal_imprinting1.04246508
103MP0003690_abnormal_glial_cell1.03350699
104MP0004197_abnormal_fetal_growth/weight/1.03062454
105MP0001727_abnormal_embryo_implantation1.02269834
106MP0002148_abnormal_hypersensitivity_rea1.01301981
107MP0000350_abnormal_cell_proliferation1.00891233
108MP0008058_abnormal_DNA_repair1.00883125
109MP0000372_irregular_coat_pigmentation0.98304132
110MP0002896_abnormal_bone_mineralization0.97630714
111MP0000266_abnormal_heart_morphology0.97285778
112MP0001730_embryonic_growth_arrest0.97266497
113MP0010155_abnormal_intestine_physiology0.96895244
114MP0003279_aneurysm0.96823814
115MP0004233_abnormal_muscle_weight0.96577953
116MP0003448_altered_tumor_morphology0.95509985
117MP0003186_abnormal_redox_activity0.94894562
118MP0002452_abnormal_antigen_presenting0.94665646
119MP0002086_abnormal_extraembryonic_tissu0.94188394
120MP0003137_abnormal_impulse_conducting0.93513822
121MP0009785_altered_susceptibility_to0.93356040
122MP0008004_abnormal_stomach_pH0.93304406
123MP0004185_abnormal_adipocyte_glucose0.92121204
124MP0004782_abnormal_surfactant_physiolog0.90807566
125MP0009333_abnormal_splenocyte_physiolog0.89724615
126MP0002396_abnormal_hematopoietic_system0.89438880
127MP0003806_abnormal_nucleotide_metabolis0.87158375
128MP0002933_joint_inflammation0.87036655
129MP0000858_altered_metastatic_potential0.86653344
130MP0001853_heart_inflammation0.86482084
131MP0000678_abnormal_parathyroid_gland0.86115600
132MP0000516_abnormal_urinary_system0.85705368
133MP0005367_renal/urinary_system_phenotyp0.85705368
134MP0004808_abnormal_hematopoietic_stem0.84458839
135MP0004145_abnormal_muscle_electrophysio0.84013223
136MP0002925_abnormal_cardiovascular_devel0.83417625
137MP0009278_abnormal_bone_marrow0.83058609
138MP0000371_diluted_coat_color0.83056338
139MP0002098_abnormal_vibrissa_morphology0.81870404
140MP0009931_abnormal_skin_appearance0.80705860
141MP0001845_abnormal_inflammatory_respons0.80490176
142MP0001697_abnormal_embryo_size0.79481144
143MP0000609_abnormal_liver_physiology0.77995419
144MP0002723_abnormal_immune_serum0.77422012
145MP0000747_muscle_weakness0.76884980
146MP0003786_premature_aging0.76439614
147MP0008469_abnormal_protein_level0.74572111
148MP0001851_eye_inflammation0.71948476
149MP0005167_abnormal_blood-brain_barrier0.70150098
150MP0002128_abnormal_blood_circulation0.69895715
151MP0005197_abnormal_uvea_morphology0.69365641
152MP0005464_abnormal_platelet_physiology0.69356866
153MP0005377_hearing/vestibular/ear_phenot0.69355949
154MP0003878_abnormal_ear_physiology0.69355949
155MP0005647_abnormal_sex_gland0.68958261
156MP0001849_ear_inflammation0.68601612
157MP0005503_abnormal_tendon_morphology0.68106966
158MP0005166_decreased_susceptibility_to0.68023052
159MP0000685_abnormal_immune_system0.67723098
160MP0002060_abnormal_skin_morphology0.67454012
161MP0002405_respiratory_system_inflammati0.67418499
162MP0002419_abnormal_innate_immunity0.67140622
163MP0000003_abnormal_adipose_tissue0.67052464
164MP0008932_abnormal_embryonic_tissue0.66607194

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)6.01635257
2Ventricular tachycardia (HP:0004756)4.38053307
3Abnormality of liposaccharide metabolism (HP:0010968)4.21577779
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.21577779
5Abnormality of glycolipid metabolism (HP:0010969)4.21577779
6Abnormality of nail color (HP:0100643)4.20839771
7Sudden death (HP:0001699)3.96496323
8Calf muscle hypertrophy (HP:0008981)3.95067467
9Increased connective tissue (HP:0009025)3.93138336
10Lipoatrophy (HP:0100578)3.78766607
11Rhabdomyolysis (HP:0003201)3.75709174
12Myoglobinuria (HP:0002913)3.63884274
13Subaortic stenosis (HP:0001682)3.63210737
14Abnormality of the left ventricular outflow tract (HP:0011103)3.63210737
15Distal lower limb muscle weakness (HP:0009053)3.57294035
16Right ventricular cardiomyopathy (HP:0011663)3.56894471
17Exercise-induced myalgia (HP:0003738)3.55865036
18Muscle hypertrophy of the lower extremities (HP:0008968)3.52475917
19Muscle fiber splitting (HP:0003555)3.51914919
20Atrial fibrillation (HP:0005110)3.44276003
21Abnormality of the calf musculature (HP:0001430)3.29134219
22Abnormal gallbladder physiology (HP:0012438)3.27447415
23Cholecystitis (HP:0001082)3.27447415
24Primary atrial arrhythmia (HP:0001692)3.17161648
25Hyporeflexia of lower limbs (HP:0002600)3.10018258
26Neurofibrillary tangles (HP:0002185)3.07205980
27Supraventricular tachycardia (HP:0004755)3.07006015
28Supraventricular arrhythmia (HP:0005115)3.03629054
29EMG: myopathic abnormalities (HP:0003458)3.02517820
30Axonal loss (HP:0003447)2.87946340
31Myocardial infarction (HP:0001658)2.87261661
32Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.87225552
33Muscle fiber inclusion bodies (HP:0100299)2.86582817
34Deep venous thrombosis (HP:0002625)2.84850446
35Dilated cardiomyopathy (HP:0001644)2.82598342
36Segmental peripheral demyelination/remyelination (HP:0003481)2.82334319
37Increased cerebral lipofuscin (HP:0011813)2.81051141
38Abnormality of macrophages (HP:0004311)2.80234577
39Type 1 muscle fiber predominance (HP:0003803)2.78553808
40Thick nail (HP:0001805)2.78300709
41Vacuolated lymphocytes (HP:0001922)2.77199631
42Hypoplastic ischia (HP:0003175)2.70073533
43Flat acetabular roof (HP:0003180)2.67936945
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.67570055
45Cerebral inclusion bodies (HP:0100314)2.64617022
46Vitreoretinal degeneration (HP:0000655)2.60797622
47Metaphyseal cupping (HP:0003021)2.59086034
48Protrusio acetabuli (HP:0003179)2.58056030
49Nuclear cataract (HP:0100018)2.50650553
50Dysostosis multiplex (HP:0000943)2.50112797
51Loss of speech (HP:0002371)2.49819451
52Increased IgE level (HP:0003212)2.48073930
53Nemaline bodies (HP:0003798)2.46175096
54Patent foramen ovale (HP:0001655)2.45238944
55Disinhibition (HP:0000734)2.44517968
56Systemic lupus erythematosus (HP:0002725)2.40429171
57Recurrent bacterial skin infections (HP:0005406)2.33842642
58Vertebral compression fractures (HP:0002953)2.27909484
59Abnormality of the ischium (HP:0003174)2.23386966
60Premature rupture of membranes (HP:0001788)2.19367226
61Hemorrhage of the eye (HP:0011885)2.17528326
62Palpitations (HP:0001962)2.16011893
63Neck muscle weakness (HP:0000467)2.14456954
64Palmoplantar hyperkeratosis (HP:0000972)2.14331991
65Tetraparesis (HP:0002273)2.13918807
66Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.13740405
67Asymmetry of the thorax (HP:0001555)2.13643987
68Pulmonary artery stenosis (HP:0004415)2.12063348
69Preauricular pit (HP:0004467)2.09262082
70Periauricular skin pits (HP:0100277)2.09262082
71Areflexia of lower limbs (HP:0002522)2.09216526
72Amyloidosis (HP:0011034)2.09164833
73Glomerulonephritis (HP:0000099)2.08982893
74Mucopolysacchariduria (HP:0008155)2.08537968
75Urinary glycosaminoglycan excretion (HP:0003541)2.08537968
76Eczematoid dermatitis (HP:0000976)2.07054215
77Upper motor neuron abnormality (HP:0002127)2.06319216
78Esophageal varix (HP:0002040)2.05605816
79Spinal cord lesions (HP:0100561)2.04660458
80Syringomyelia (HP:0003396)2.04660458
81Irregular epiphyses (HP:0010582)2.03659639
82Rectal fistula (HP:0100590)2.03309223
83Rectovaginal fistula (HP:0000143)2.03309223
84Gangrene (HP:0100758)2.03145545
85Palmar hyperkeratosis (HP:0010765)2.02445714
86Asymmetric septal hypertrophy (HP:0001670)1.99802467
87Carpal bone hypoplasia (HP:0001498)1.99576542
88Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98633993
89Abnormality of polysaccharide metabolism (HP:0011012)1.98633993
90Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98633993
91Thin bony cortex (HP:0002753)1.98617529
92Increased neuronal autofluorescent lipopigment (HP:0002074)1.97548569
93Multiple enchondromatosis (HP:0005701)1.97264339
94Plantar hyperkeratosis (HP:0007556)1.97211722
95Intestinal fistula (HP:0100819)1.95729117
96Small epiphyses (HP:0010585)1.94528362
97Chromsome breakage (HP:0040012)1.94348073
98Nausea (HP:0002018)1.92999763
99Abnormality of glycolysis (HP:0004366)1.92723012
100Apathy (HP:0000741)1.90562017
101Urethral obstruction (HP:0000796)1.89613351
102Alopecia of scalp (HP:0002293)1.88980889
103Ventricular arrhythmia (HP:0004308)1.88318544
104Difficulty climbing stairs (HP:0003551)1.87702007
105Neonatal short-limb short stature (HP:0008921)1.87404963
106Subacute progressive viral hepatitis (HP:0006572)1.86383863
107Congenital ichthyosiform erythroderma (HP:0007431)1.86028656
108Bone pain (HP:0002653)1.85587851
109Hip contracture (HP:0003273)1.85125648
110Cupped ribs (HP:0000887)1.83221001
111Abnormality of carpal bone ossification (HP:0006257)1.83181637
112Hyperacusis (HP:0010780)1.82192210
113Ulnar deviation of the wrist (HP:0003049)1.81936230
114Skin nodule (HP:0200036)1.81498953
115Diminished motivation (HP:0000745)1.81060772
116Palmoplantar keratoderma (HP:0000982)1.81012147
117Pigmentary retinal degeneration (HP:0001146)1.80703150
118Hypercholesterolemia (HP:0003124)1.79896095
119Difficulty running (HP:0009046)1.79363458
120Neuronal loss in central nervous system (HP:0002529)1.77707158
121Natal tooth (HP:0000695)1.77572051
122Mildly elevated creatine phosphokinase (HP:0008180)1.77006010
123Abnormal tarsal ossification (HP:0008369)1.76347058
124Disproportionate tall stature (HP:0001519)1.76141508
125Dyschromatopsia (HP:0007641)1.75793858
126Peripheral demyelination (HP:0011096)1.75294485
127Atrophic scars (HP:0001075)1.74718776
128Distal lower limb amyotrophy (HP:0008944)1.70837711
129Scapular winging (HP:0003691)1.70770940
130Abnormality of the lumbar spine (HP:0100712)1.70169632
131Onycholysis (HP:0001806)1.70012955
132Chromosomal breakage induced by crosslinking agents (HP:0003221)1.69862233
133Selective tooth agenesis (HP:0001592)1.69297386
134Esophageal neoplasm (HP:0100751)1.68501914
135Neoplasm of head and neck (HP:0012288)1.68501914
136Centrally nucleated skeletal muscle fibers (HP:0003687)1.67997520
137Transposition of the great arteries (HP:0001669)1.67887175
138Abnormal connection of the cardiac segments (HP:0011545)1.67887175
139Abnormal ventriculo-arterial connection (HP:0011563)1.67887175
140Advanced eruption of teeth (HP:0006288)1.67282787
141Keratoconjunctivitis sicca (HP:0001097)1.66605748
142Metaphyseal irregularity (HP:0003025)1.66348778
143Depressed nasal tip (HP:0000437)1.66070933
144Arterial tortuosity (HP:0005116)1.65985520
145Long clavicles (HP:0000890)1.65639523
146Duplicated collecting system (HP:0000081)1.65331462
147Cerebral aneurysm (HP:0004944)1.65056143
148Prostate neoplasm (HP:0100787)1.64285136
149Congenital stationary night blindness (HP:0007642)1.64096507
150Skin pits (HP:0100276)1.63989242
151Spinal rigidity (HP:0003306)1.63612899
152Generalized muscle weakness (HP:0003324)1.63136402
153Vaginal fistula (HP:0004320)1.63118796
154Ankyloglossia (HP:0010296)1.62136746
155Ectropion (HP:0000656)1.61689175
156Recurrent abscess formation (HP:0002722)1.61663755
157Mediastinal lymphadenopathy (HP:0100721)1.61614844
158Abnormal ossification of hand bones (HP:0005921)1.60723885
159Syncope (HP:0001279)1.60431806
160Orchitis (HP:0100796)1.60430235
161Chorioretinal atrophy (HP:0000533)1.60086355
162Erythema (HP:0010783)1.60084760
163Abnormality of the salivary glands (HP:0010286)1.58429596
164Hypertriglyceridemia (HP:0002155)1.58354416
165Coarse hair (HP:0002208)1.58353858
166Retrobulbar optic neuritis (HP:0100654)1.58320107
167Optic neuritis (HP:0100653)1.58320107
168Aplasia/hypoplasia of the humerus (HP:0006507)1.57897694
169Hammertoe (HP:0001765)1.57327403
170Persistence of primary teeth (HP:0006335)1.57046850
171Termporal pattern (HP:0011008)1.56960737
172Insidious onset (HP:0003587)1.56960737
173Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.56626706
174Abnormality of the acetabulum (HP:0003170)1.56492806
175Distal upper limb amyotrophy (HP:0007149)1.56040858
176Upper limb amyotrophy (HP:0009129)1.56040858
177Abnormal atrioventricular conduction (HP:0005150)1.55953296
178Ureteral duplication (HP:0000073)1.55886017
179Short humerus (HP:0005792)1.55647618
180Epiphyseal dysplasia (HP:0002656)1.55025997
181Vertebral arch anomaly (HP:0008438)1.54886764
182Femoral bowing (HP:0002980)1.54649911
183Recurrent gram-negative bacterial infections (HP:0005420)1.53747452
184Agnosia (HP:0010524)1.53657997
185Rimmed vacuoles (HP:0003805)1.52055331
186Abnormality of the renal collecting system (HP:0004742)1.51427140
187Osteolytic defects of the hand bones (HP:0009699)1.50585149
188Osteolytic defects of the phalanges of the hand (HP:0009771)1.50585149

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.63112202
2ZAK3.23663898
3TTN3.17641962
4STK38L2.63787712
5ICK2.63566473
6STK242.52970819
7PKN22.51298088
8PRPF4B2.44980111
9MAP3K32.36827439
10FGFR42.33081645
11DDR22.29869054
12CDK122.19761423
13MAP3K132.16982690
14LATS22.14616205
15MOS2.13662552
16MYLK2.12241226
17EPHA21.98367585
18PDGFRA1.97516532
19ERN11.95619706
20MAP3K91.91711400
21MAP3K141.87187969
22PDK21.85534015
23PIK3CA1.83865181
24BLK1.70935108
25MST1R1.68774945
26MAP2K31.66815520
27PBK1.63006843
28FLT31.60104369
29TRPM71.59688213
30NEK11.56882295
31FGR1.55217407
32RPS6KB21.54582863
33MATK1.51841213
34KSR21.49456359
35SMG11.48854925
36RIPK41.48247579
37STK41.47101205
38SIK11.33254071
39TTK1.32316762
40TYRO31.30600440
41WEE11.29886198
42STK31.26760008
43NEK91.24968177
44BRSK21.24168402
45ARAF1.20538243
46PIM11.20213073
47MARK31.19979112
48GRK71.19129471
49BRD41.18093339
50STK101.12254497
51PDK31.12238449
52PDK41.12238449
53YES11.07061417
54RPS6KA41.05414586
55PINK11.05215180
56EPHB11.05196520
57MET1.03819044
58TSSK61.03770095
59RIPK11.02002270
60IKBKB1.01605236
61CSK1.01576045
62IRAK41.00963393
63IRAK31.00773909
64CDC42BPA1.00412833
65DMPK0.99936933
66EIF2AK10.99829279
67TGFBR10.99798378
68TGFBR20.98738417
69FGFR30.97805040
70MAP3K60.95511741
71JAK30.95416297
72NME20.95220322
73LATS10.95187264
74MAP3K10.94423411
75PLK40.91843712
76CHUK0.91745273
77SRPK10.89761418
78CAMK1D0.87810387
79SIK20.86797591
80SIK30.86612702
81EPHA30.85200726
82CDK40.84675456
83PAK40.84589759
84EIF2AK20.83134374
85RET0.83046094
86MTOR0.82240397
87MAP3K100.81963429
88PIM20.81940901
89PLK30.79843840
90AKT30.79343921
91PDGFRB0.78375276
92BMX0.78277995
93PTK60.77570507
94AURKB0.77407860
95MAP3K80.76388289
96CDK70.76353891
97MKNK10.75344505
98FGFR10.75047969
99JAK20.74753772
100EEF2K0.73963988
101KSR10.73236288
102NTRK10.71315376
103TAOK10.70588895
104ATR0.70192988
105CDC70.69522836
106PLK10.69384259
107CLK10.68631841
108ZAP700.67500160
109MELK0.66460615
110ILK0.64246263
111MKNK20.64190488
112TXK0.64084519
113DYRK1B0.62787978
114PDPK10.62692762
115PHKG20.62342628
116PHKG10.62342628
117ERBB30.62283214
118WNK10.60036307
119LMTK20.59949824
120TESK10.57176265
121TAOK20.56277668
122RPS6KC10.56025241
123RPS6KL10.56025241
124CAMK1G0.55757332
125ALK0.55459331
126PRKAA20.54391406
127PTK20.54292676
128MAPKAPK30.54052139
129MAP3K50.53768743
130TBK10.53526415
131TNIK0.53276253
132CDK60.52723689
133PASK0.52079964
134EIF2AK30.51563137
135RPS6KA20.51026484
136RPS6KA60.50186767
137CSF1R0.49059182
138PRKG20.48771181
139IRAK10.48304317
140EPHB20.46352933
141AKT20.46194583
142TYK20.45837783
143RPS6KA10.45562916
144MST40.45151900
145TRIB30.44838319
146BCR0.44238949
147MAPKAPK20.43665980
148CDK90.42767364
149PDK10.41200563
150NUAK10.39963425
151ATM0.39727427
152IKBKE0.39517209
153JAK10.38487656
154PAK20.38316010
155NEK60.38284390
156CHEK10.37838201
157NME10.37713671
158MUSK0.37676102
159MAP3K110.36933934
160NEK20.35561559

Predicted pathways (KEGG)

RankGene SetZ-score
1* Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.01313599
2Other glycan degradation_Homo sapiens_hsa005112.94595319
3DNA replication_Homo sapiens_hsa030302.40955622
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.40794478
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.40715494
6Mismatch repair_Homo sapiens_hsa034302.13418941
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.10015029
8Dilated cardiomyopathy_Homo sapiens_hsa054142.07011633
9Legionellosis_Homo sapiens_hsa051342.00240486
10Lysosome_Homo sapiens_hsa041421.86704097
11Bladder cancer_Homo sapiens_hsa052191.85580590
12One carbon pool by folate_Homo sapiens_hsa006701.80388908
13Cardiac muscle contraction_Homo sapiens_hsa042601.77939084
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77033790
15* Fructose and mannose metabolism_Homo sapiens_hsa000511.72796935
16Graft-versus-host disease_Homo sapiens_hsa053321.71395561
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.69344671
18RNA transport_Homo sapiens_hsa030131.66117930
19Homologous recombination_Homo sapiens_hsa034401.63140026
20Base excision repair_Homo sapiens_hsa034101.59601415
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.58501076
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58313626
23Viral myocarditis_Homo sapiens_hsa054161.56546805
24Leishmaniasis_Homo sapiens_hsa051401.55850820
25RNA degradation_Homo sapiens_hsa030181.48479977
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47894075
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.45940532
28Pentose phosphate pathway_Homo sapiens_hsa000301.43225744
29Renal cell carcinoma_Homo sapiens_hsa052111.39864488
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39654078
31Phototransduction_Homo sapiens_hsa047441.38087657
32Fatty acid biosynthesis_Homo sapiens_hsa000611.37838761
33PPAR signaling pathway_Homo sapiens_hsa033201.37640630
34Proteasome_Homo sapiens_hsa030501.34051599
35Cell cycle_Homo sapiens_hsa041101.33583774
36* HIF-1 signaling pathway_Homo sapiens_hsa040661.32784030
37RNA polymerase_Homo sapiens_hsa030201.32269556
38Spliceosome_Homo sapiens_hsa030401.24491757
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24251021
40Herpes simplex infection_Homo sapiens_hsa051681.22968996
41Pancreatic cancer_Homo sapiens_hsa052121.21922550
42Nucleotide excision repair_Homo sapiens_hsa034201.20214711
43Prion diseases_Homo sapiens_hsa050201.19592775
44VEGF signaling pathway_Homo sapiens_hsa043701.17409785
45* Carbon metabolism_Homo sapiens_hsa012001.16793731
46Adherens junction_Homo sapiens_hsa045201.14949426
47Small cell lung cancer_Homo sapiens_hsa052221.14665003
48Ribosome_Homo sapiens_hsa030101.14384915
49Non-homologous end-joining_Homo sapiens_hsa034501.12961333
50B cell receptor signaling pathway_Homo sapiens_hsa046621.11925999
51ECM-receptor interaction_Homo sapiens_hsa045121.11823693
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09529694
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09214044
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08434129
55Hepatitis C_Homo sapiens_hsa051601.08025864
56Measles_Homo sapiens_hsa051621.07761012
57* Galactose metabolism_Homo sapiens_hsa000521.06093356
58Fanconi anemia pathway_Homo sapiens_hsa034601.05853631
59p53 signaling pathway_Homo sapiens_hsa041151.04619978
60* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04201491
61TNF signaling pathway_Homo sapiens_hsa046681.02987921
62Malaria_Homo sapiens_hsa051441.02142804
63Influenza A_Homo sapiens_hsa051641.01885193
64Non-small cell lung cancer_Homo sapiens_hsa052231.01863018
65Prolactin signaling pathway_Homo sapiens_hsa049171.01552979
66Antigen processing and presentation_Homo sapiens_hsa046121.01397353
67Parkinsons disease_Homo sapiens_hsa050121.00370837
68HTLV-I infection_Homo sapiens_hsa051660.98941079
69Phagosome_Homo sapiens_hsa041450.98620949
70Pyrimidine metabolism_Homo sapiens_hsa002400.97001226
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96023277
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95890172
73Apoptosis_Homo sapiens_hsa042100.95797512
74Steroid biosynthesis_Homo sapiens_hsa001000.94622126
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94256660
76Epstein-Barr virus infection_Homo sapiens_hsa051690.94248162
77Osteoclast differentiation_Homo sapiens_hsa043800.93594646
78Shigellosis_Homo sapiens_hsa051310.93539009
79Toxoplasmosis_Homo sapiens_hsa051450.92702545
80TGF-beta signaling pathway_Homo sapiens_hsa043500.92439258
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92322769
82* Central carbon metabolism in cancer_Homo sapiens_hsa052300.91724777
83Focal adhesion_Homo sapiens_hsa045100.89959132
84Biosynthesis of amino acids_Homo sapiens_hsa012300.89674940
85Endometrial cancer_Homo sapiens_hsa052130.88957232
86Complement and coagulation cascades_Homo sapiens_hsa046100.87309515
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86967192
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86767426
89Huntingtons disease_Homo sapiens_hsa050160.85180574
90MicroRNAs in cancer_Homo sapiens_hsa052060.84252740
91Allograft rejection_Homo sapiens_hsa053300.83584532
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.83527439
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.83266264
94Tight junction_Homo sapiens_hsa045300.81820244
95* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81794126
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80827626
97African trypanosomiasis_Homo sapiens_hsa051430.80172351
98ErbB signaling pathway_Homo sapiens_hsa040120.79008095
99Notch signaling pathway_Homo sapiens_hsa043300.78622696
100* Insulin signaling pathway_Homo sapiens_hsa049100.78573759
101Viral carcinogenesis_Homo sapiens_hsa052030.74687524
102Prostate cancer_Homo sapiens_hsa052150.73967390
103Oxidative phosphorylation_Homo sapiens_hsa001900.73853616
104Chemokine signaling pathway_Homo sapiens_hsa040620.72868761
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72816891
106Amoebiasis_Homo sapiens_hsa051460.72766241
107mRNA surveillance pathway_Homo sapiens_hsa030150.72432222
108Hematopoietic cell lineage_Homo sapiens_hsa046400.71179891
109Proteoglycans in cancer_Homo sapiens_hsa052050.70945120
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70314352
111Salmonella infection_Homo sapiens_hsa051320.69844341
112AMPK signaling pathway_Homo sapiens_hsa041520.69616373
113Thyroid cancer_Homo sapiens_hsa052160.68336376
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67618743
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67219173
116Purine metabolism_Homo sapiens_hsa002300.66232148
117Hippo signaling pathway_Homo sapiens_hsa043900.65417923
118Pertussis_Homo sapiens_hsa051330.64846905
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.64655066
120Acute myeloid leukemia_Homo sapiens_hsa052210.64594314
121Insulin resistance_Homo sapiens_hsa049310.64287753
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.63571558
123mTOR signaling pathway_Homo sapiens_hsa041500.63023266
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62266576
125Chronic myeloid leukemia_Homo sapiens_hsa052200.61693172
126Sphingolipid metabolism_Homo sapiens_hsa006000.61401663
127Rheumatoid arthritis_Homo sapiens_hsa053230.59516665
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.59217505
129Renin-angiotensin system_Homo sapiens_hsa046140.58800225
130Basal transcription factors_Homo sapiens_hsa030220.57833783
131Arachidonic acid metabolism_Homo sapiens_hsa005900.57800433
132GnRH signaling pathway_Homo sapiens_hsa049120.55346278
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.55289996
134Systemic lupus erythematosus_Homo sapiens_hsa053220.54835996
135Hepatitis B_Homo sapiens_hsa051610.54469547
136Fatty acid metabolism_Homo sapiens_hsa012120.53336555
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51472355
138Pathways in cancer_Homo sapiens_hsa052000.51032762
139Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50437382
140Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49387507
141Tuberculosis_Homo sapiens_hsa051520.47209567
142Colorectal cancer_Homo sapiens_hsa052100.47106797
143Staphylococcus aureus infection_Homo sapiens_hsa051500.46799149
144Glutathione metabolism_Homo sapiens_hsa004800.46228685
145Propanoate metabolism_Homo sapiens_hsa006400.44974078
146Phospholipase D signaling pathway_Homo sapiens_hsa040720.44865212
147FoxO signaling pathway_Homo sapiens_hsa040680.42917484
148T cell receptor signaling pathway_Homo sapiens_hsa046600.42248471

Most similar genes based on co-expression Upload to Enrichr

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