HK2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to cilium (GO:0061512)5.84379920
2regulation of vitamin D biosynthetic process (GO:0060556)5.79781654
3regulation of cytokine secretion involved in immune response (GO:0002739)5.32351991
4regulation of fever generation (GO:0031620)5.31142773
5negative regulation of interleukin-12 production (GO:0032695)5.29375370
6positive regulation of heat generation (GO:0031652)5.26648651
7regulation of chronic inflammatory response (GO:0002676)4.38671111
8regulation of vitamin metabolic process (GO:0030656)4.27965201
9positive regulation of chemokine biosynthetic process (GO:0045080)4.25436960
10response to peptidoglycan (GO:0032494)4.17111319
11positive regulation of defense response to virus by host (GO:0002230)4.11011245
12neutrophil activation involved in immune response (GO:0002283)3.95709083
13lipopolysaccharide-mediated signaling pathway (GO:0031663)3.89301855
14regulation of heat generation (GO:0031650)3.81155077
15positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.76971975
16regulation of mononuclear cell migration (GO:0071675)3.73670458
17regulation of T-helper 1 cell differentiation (GO:0045625)3.68048644
18regulation of chemokine biosynthetic process (GO:0045073)3.67594436
19positive regulation of cellular amide metabolic process (GO:0034250)3.62489460
20interferon-gamma secretion (GO:0072643)3.58985021
21branching involved in labyrinthine layer morphogenesis (GO:0060670)3.57170767
22DNA damage response, detection of DNA damage (GO:0042769)3.56082124
23CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.54424546
24positive regulation of gamma-delta T cell activation (GO:0046645)3.50459676
25granulocyte activation (GO:0036230)3.49697273
26positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.47404156
27regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.34876522
28neutrophil activation (GO:0042119)3.34690639
29positive regulation of tolerance induction (GO:0002645)3.33885492
30positive regulation of acute inflammatory response (GO:0002675)3.31537853
31regulation of T cell tolerance induction (GO:0002664)3.29579498
32defense response to protozoan (GO:0042832)3.22324320
33regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.20089890
34regulation of inflammatory response to antigenic stimulus (GO:0002861)3.15355647
35response to protozoan (GO:0001562)3.12109975
36positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.11581699
37response to manganese ion (GO:0010042)3.11576026
38negative regulation of interleukin-17 production (GO:0032700)3.10267690
39regulation of defense response to virus by host (GO:0050691)3.08315612
40NIK/NF-kappaB signaling (GO:0038061)3.06579827
41response to muramyl dipeptide (GO:0032495)3.05767485
42T-helper 1 type immune response (GO:0042088)3.04936110
43T-helper cell differentiation (GO:0042093)2.98463569
44CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.98463569
45cellular response to lipopolysaccharide (GO:0071222)2.98262677
46regulation of tolerance induction (GO:0002643)2.97379791
47regulation of podosome assembly (GO:0071801)2.96911202
48viral transcription (GO:0019083)2.96306981
49regulation of interleukin-12 production (GO:0032655)2.93625395
50positive regulation of T-helper cell differentiation (GO:0045624)2.92944403
51regulation of antigen processing and presentation (GO:0002577)2.89744059
52positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.89480644
53negative regulation of monooxygenase activity (GO:0032769)2.89122351
54cellular response to molecule of bacterial origin (GO:0071219)2.87537992
55negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.86220639
56negative regulation of alpha-beta T cell activation (GO:0046636)2.85898996
57positive regulation of T-helper 1 type immune response (GO:0002827)2.84520550
58negative regulation of growth of symbiont in host (GO:0044130)2.83935248
59negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.83935248
60modulation of growth of symbiont involved in interaction with host (GO:0044144)2.83935248
61regulation of growth of symbiont in host (GO:0044126)2.83935248
62negative regulation of myeloid cell apoptotic process (GO:0033033)2.82776599
63regulation of monocyte chemotaxis (GO:0090025)2.81817667
64regulation of interferon-gamma biosynthetic process (GO:0045072)2.78839262
65regulation of T cell mediated cytotoxicity (GO:0001914)2.75995538
66positive regulation of NF-kappaB import into nucleus (GO:0042346)2.75443720
67negative regulation of cytokine production involved in immune response (GO:0002719)2.74308614
68negative regulation of interleukin-10 production (GO:0032693)2.71780858
69regulation of B cell receptor signaling pathway (GO:0050855)2.69772617
70regulation of lymphocyte migration (GO:2000401)2.69421995
71regulation of T-helper cell differentiation (GO:0045622)2.68794138
72maturation of SSU-rRNA (GO:0030490)2.67643130
73positive regulation of interleukin-6 production (GO:0032755)2.65600745
74regulation of dendritic cell antigen processing and presentation (GO:0002604)2.63652937
75positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.63319366
76positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.60540544
77translational termination (GO:0006415)2.59828034
78regulation of membrane protein ectodomain proteolysis (GO:0051043)2.59119199
79macrophage activation involved in immune response (GO:0002281)2.59104236
80cytokine secretion (GO:0050663)2.58338158
81positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.58174166
82leukocyte aggregation (GO:0070486)2.58014781
83regulation of interleukin-17 production (GO:0032660)2.57409462
84type I interferon signaling pathway (GO:0060337)2.56069180
85cellular response to type I interferon (GO:0071357)2.56069180
86regulation of interferon-alpha production (GO:0032647)2.55505031
87negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.55149785
88cellular response to biotic stimulus (GO:0071216)2.54292484
89limb bud formation (GO:0060174)2.54212946
90negative regulation of cell killing (GO:0031342)2.53699362
91negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.53699362
92T cell activation involved in immune response (GO:0002286)2.53017955
93response to type I interferon (GO:0034340)2.50922549
94interferon-gamma-mediated signaling pathway (GO:0060333)2.50595529
95positive regulation of transcription factor import into nucleus (GO:0042993)2.49504214
96positive regulation of natural killer cell differentiation (GO:0032825)2.49433888
97regulation of alpha-beta T cell activation (GO:0046634)2.48956187
98negative regulation of tumor necrosis factor production (GO:0032720)2.48311896
99negative regulation of nitric-oxide synthase activity (GO:0051001)2.47875614
100alpha-beta T cell activation involved in immune response (GO:0002287)2.46774886

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.54478748
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.87244116
3STAT6_21828071_ChIP-Seq_BEAS2B_Human4.61196497
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.96076196
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.64308803
6RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.43923956
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.00132736
8ZNF263_19887448_ChIP-Seq_K562_Human2.99313233
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.97908994
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.95511977
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.88930448
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.81260720
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.73625926
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.59643814
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.46561458
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.43913717
17ESR1_15608294_ChIP-ChIP_MCF-7_Human2.43505197
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.35106591
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.32743853
20NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human2.32556924
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.31694628
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27705075
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20710241
24PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.08569402
25MYB_26560356_Chip-Seq_TH2_Human2.07228840
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.03984892
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02312475
28VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.01476748
29SPI1_23547873_ChIP-Seq_NB4_Human1.96362641
30VDR_24787735_ChIP-Seq_THP-1_Human1.95119128
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.79224720
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.77828270
33RUNX_20019798_ChIP-Seq_JUKART_Human1.77812083
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.77307252
35MAF_26560356_Chip-Seq_TH1_Human1.76535213
36ELF1_20517297_ChIP-Seq_JURKAT_Human1.76005567
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73313196
38MYC_22102868_ChIP-Seq_BL_Human1.70360249
39VDR_24763502_ChIP-Seq_THP-1_Human1.63226796
40IRF1_19129219_ChIP-ChIP_H3396_Human1.57711268
41MYB_26560356_Chip-Seq_TH1_Human1.57249414
42VDR_21846776_ChIP-Seq_THP-1_Human1.56328302
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.54679300
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54009288
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51098733
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48163723
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.45711476
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43289874
49PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.43185970
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42081273
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.41661219
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41014812
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29955204
54TP63_17297297_ChIP-ChIP_HaCaT_Human1.28303743
55PU_27001747_Chip-Seq_BMDM_Mouse1.26053425
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24981312
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23310425
58CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21416376
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18996887
60FOXM1_23109430_ChIP-Seq_U2OS_Human1.18905037
61UTX_26944678_Chip-Seq_JUKART_Human1.17569870
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.16887053
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13970436
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13572852
65GATA3_26560356_Chip-Seq_TH2_Human1.13096196
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12984785
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11967024
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11610345
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11599831
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10060732
71SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07153130
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06023293
73ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.05033616
74LXR_22292898_ChIP-Seq_THP-1_Human1.04681344
75SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.01370480
76SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01098346
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99924028
78PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99836924
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99808559
80MAF_26560356_Chip-Seq_TH2_Human0.96729258
81KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95709379
82PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93479499
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92019254
84GATA2_21666600_ChIP-Seq_HMVEC_Human0.91972957
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91099807
86RUNX1_22412390_ChIP-Seq_EML_Mouse0.90809448
87WT1_19549856_ChIP-ChIP_CCG9911_Human0.90468531
88EED_16625203_ChIP-ChIP_MESCs_Mouse0.89594094
89RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88041520
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86634387
91BCOR_27268052_Chip-Seq_Bcells_Human0.85198634
92SPI1_23127762_ChIP-Seq_K562_Human0.85184801
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82430387
94YY1_22570637_ChIP-Seq_MALME-3M_Human0.79595925
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75341475
96PCGF2_27294783_Chip-Seq_NPCs_Mouse0.74520098
97TP53_20018659_ChIP-ChIP_R1E_Mouse0.73740165
98EZH2_27304074_Chip-Seq_ESCs_Mouse0.73043305
99GATA3_27048872_Chip-Seq_THYMUS_Human0.71370204
100CTCF_21964334_ChIP-Seq_BJAB-B_Human0.70868418

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.89880811
2MP0003436_decreased_susceptibility_to3.81978841
3MP0003724_increased_susceptibility_to3.62367428
4MP0009785_altered_susceptibility_to3.47626339
5MP0002148_abnormal_hypersensitivity_rea3.32313158
6MP0002822_catalepsy3.16562279
7MP0003806_abnormal_nucleotide_metabolis3.11810575
8MP0009764_decreased_sensitivity_to3.01251692
9MP0001835_abnormal_antigen_presentation2.99068893
10MP0005671_abnormal_response_to2.87381863
11MP0005000_abnormal_immune_tolerance2.87262568
12MP0008004_abnormal_stomach_pH2.70978934
13MP0005025_abnormal_response_to2.40704773
14MP0001790_abnormal_immune_system2.37302004
15MP0005387_immune_system_phenotype2.37302004
16MP0004947_skin_inflammation2.36086758
17MP0001800_abnormal_humoral_immune2.33379007
18MP0000685_abnormal_immune_system2.31379064
19MP0002452_abnormal_antigen_presenting2.28183731
20MP0002419_abnormal_innate_immunity2.27830185
21MP0003300_gastrointestinal_ulcer2.23813298
22MP0002723_abnormal_immune_serum2.18899173
23MP0008438_abnormal_cutaneous_collagen2.07454160
24MP0001533_abnormal_skeleton_physiology2.04752197
25MP0003950_abnormal_plasma_membrane2.03407376
26MP0009278_abnormal_bone_marrow1.89109045
27MP0000343_altered_response_to1.88880427
28MP0006054_spinal_hemorrhage1.87839888
29MP0001819_abnormal_immune_cell1.85772638
30MP0002420_abnormal_adaptive_immunity1.81354044
31MP0009697_abnormal_copulation1.81224566
32MP0009765_abnormal_xenobiotic_induced1.78107232
33MP0005451_abnormal_body_composition1.74973234
34MP0004510_myositis1.74063014
35MP0000858_altered_metastatic_potential1.61073606
36MP0005171_absent_coat_pigmentation1.59309041
37MP0001984_abnormal_olfaction1.58848181
38MP0002332_abnormal_exercise_endurance1.57503474
39MP0002405_respiratory_system_inflammati1.56885045
40MP0001845_abnormal_inflammatory_respons1.56494510
41MP0005310_abnormal_salivary_gland1.51716691
42MP0003448_altered_tumor_morphology1.46776517
43MP0006082_CNS_inflammation1.41523608
44MP0002282_abnormal_trachea_morphology1.35722445
45MP0000750_abnormal_muscle_regeneration1.35504283
46MP0008874_decreased_physiological_sensi1.26497876
47MP0008469_abnormal_protein_level1.26475026
48MP0001853_heart_inflammation1.23582903
49MP0001919_abnormal_reproductive_system1.22097447
50MP0005623_abnormal_meninges_morphology1.19635446
51MP0005167_abnormal_blood-brain_barrier1.18463949
52MP0003453_abnormal_keratinocyte_physiol1.17717768
53MP0000716_abnormal_immune_system1.17256681
54MP0005397_hematopoietic_system_phenotyp1.12903337
55MP0001545_abnormal_hematopoietic_system1.12903337
56MP0009333_abnormal_splenocyte_physiolog1.11747427
57MP0003075_altered_response_to1.10614484
58MP0003283_abnormal_digestive_organ1.10578895
59MP0002398_abnormal_bone_marrow1.09510548
60MP0010155_abnormal_intestine_physiology1.07857363
61MP0005058_abnormal_lysosome_morphology1.07525562
62MP0009763_increased_sensitivity_to1.06212529
63MP0002928_abnormal_bile_duct1.02210902
64MP0005503_abnormal_tendon_morphology0.98985985
65MP0005076_abnormal_cell_differentiation0.98057935
66MP0002998_abnormal_bone_remodeling0.96696623
67MP0000371_diluted_coat_color0.95453414
68MP0008961_abnormal_basal_metabolism0.94826638
69MP0005275_abnormal_skin_tensile0.93239841
70MP0005390_skeleton_phenotype0.92641739
71MP0002429_abnormal_blood_cell0.90804203
72MP0003763_abnormal_thymus_physiology0.90297877
73MP0005164_abnormal_response_to0.90017677
74MP0001727_abnormal_embryo_implantation0.89811945
75MP0003172_abnormal_lysosome_physiology0.89118828
76MP0003091_abnormal_cell_migration0.82139916
77MP0005166_decreased_susceptibility_to0.81174839
78MP0003880_abnormal_central_pattern0.81134199
79MP0009053_abnormal_anal_canal0.80951444
80MP0003656_abnormal_erythrocyte_physiolo0.77411709
81MP0000579_abnormal_nail_morphology0.77091342
82MP0000372_irregular_coat_pigmentation0.76451060
83MP0002722_abnormal_immune_system0.75999681
84MP0003690_abnormal_glial_cell0.75041900
85MP0009379_abnormal_foot_pigmentation0.73584871
86MP0001440_abnormal_grooming_behavior0.70093895
87MP0000689_abnormal_spleen_morphology0.69083085
88MP0004808_abnormal_hematopoietic_stem0.68612231
89MP0005595_abnormal_vascular_smooth0.68060763
90MP0005266_abnormal_metabolism0.67234462
91MP0005464_abnormal_platelet_physiology0.66562096
92MP0000920_abnormal_myelination0.66249558
93MP0002098_abnormal_vibrissa_morphology0.65243840
94MP0003279_aneurysm0.63672963
95MP0000249_abnormal_blood_vessel0.62083313
96MP0001529_abnormal_vocalization0.59995726
97MP0002877_abnormal_melanocyte_morpholog0.57586122
98MP0005367_renal/urinary_system_phenotyp0.57396135
99MP0000516_abnormal_urinary_system0.57396135
100MP0002933_joint_inflammation0.57113692

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.73386676
2Stomach cancer (HP:0012126)4.32019925
3Mediastinal lymphadenopathy (HP:0100721)4.05939308
4Optic neuritis (HP:0100653)4.03595764
5Retrobulbar optic neuritis (HP:0100654)4.03595764
6Orchitis (HP:0100796)3.92876720
7Congenital, generalized hypertrichosis (HP:0004540)3.69746045
8Large eyes (HP:0001090)3.40821726
9Prostate neoplasm (HP:0100787)3.34527470
10Abnormality of the vasculature of the conjunctiva (HP:0008054)3.33524918
11Myositis (HP:0100614)3.28329374
12Increased IgM level (HP:0003496)3.24790423
13Abnormality of lateral ventricle (HP:0030047)3.23257571
14Parakeratosis (HP:0001036)3.16153376
15Recurrent bacterial skin infections (HP:0005406)3.15552847
16Abnormality of liposaccharide metabolism (HP:0010968)3.11933754
17Abnormality of glycosphingolipid metabolism (HP:0004343)3.11933754
18Abnormality of glycolipid metabolism (HP:0010969)3.11933754
19Abnormality of macrophages (HP:0004311)3.11210033
20Autoimmune thrombocytopenia (HP:0001973)3.10513503
21Broad distal phalanx of finger (HP:0009836)3.03682312
22Conjunctival telangiectasia (HP:0000524)2.96812514
23Gangrene (HP:0100758)2.95752682
24Upper motor neuron abnormality (HP:0002127)2.95195690
25Keratoconjunctivitis sicca (HP:0001097)2.85844808
26Woolly hair (HP:0002224)2.85171599
27Recurrent abscess formation (HP:0002722)2.83601491
28Conical tooth (HP:0000698)2.82255547
29Eczematoid dermatitis (HP:0000976)2.81473546
30Recurrent viral infections (HP:0004429)2.80574715
31Cheilitis (HP:0100825)2.78119480
32Vasculitis (HP:0002633)2.65509130
33Glomerulopathy (HP:0100820)2.65283736
34Stenosis of the external auditory canal (HP:0000402)2.64068655
35Keratitis (HP:0000491)2.63579272
36Buphthalmos (HP:0000557)2.58254410
37Abnormality of the prostate (HP:0008775)2.56423246
38Renal Fanconi syndrome (HP:0001994)2.51311332
39Gingivitis (HP:0000230)2.47204721
40Vacuolated lymphocytes (HP:0001922)2.46780515
41Pulmonary infiltrates (HP:0002113)2.46453537
42Diplopia (HP:0000651)2.44496773
43Abnormality of binocular vision (HP:0011514)2.44496773
44Joint swelling (HP:0001386)2.44042851
45Keratoconjunctivitis (HP:0001096)2.37521349
46Absent hand (HP:0004050)2.34585193
47Gastrointestinal infarctions (HP:0005244)2.31388263
48Partial duplication of thumb phalanx (HP:0009944)2.29418671
49Biconcave vertebral bodies (HP:0004586)2.26719299
50Abnormality of the right ventricle (HP:0001707)2.23184988
51Hypergammaglobulinemia (HP:0010702)2.18596266
52Choroideremia (HP:0001139)2.15728722
53Abnormality of B cell number (HP:0010975)2.15703308
54Metaphyseal irregularity (HP:0003025)2.15447216
55Abnormality of cells of the erythroid lineage (HP:0012130)2.15427816
56Difficulty climbing stairs (HP:0003551)2.13301476
57Amyotrophic lateral sclerosis (HP:0007354)2.13056686
58Thick nail (HP:0001805)2.12019862
59Restrictive lung disease (HP:0002091)2.11587384
60Ridged nail (HP:0001807)2.09754294
61Thin bony cortex (HP:0002753)2.09002726
62B lymphocytopenia (HP:0010976)2.08625894
63Elevated erythrocyte sedimentation rate (HP:0003565)2.08322942
64Polyneuropathy (HP:0001271)2.06854294
65Abnormality of the lower motor neuron (HP:0002366)2.05482708
66Colitis (HP:0002583)2.02587940
67Recurrent skin infections (HP:0001581)1.99225254
68Delayed epiphyseal ossification (HP:0002663)1.99193999
69Hemoptysis (HP:0002105)1.96303342
70Esophageal neoplasm (HP:0100751)1.95210621
71Neoplasm of head and neck (HP:0012288)1.95210621
72Patent foramen ovale (HP:0001655)1.94913524
73Partial duplication of the phalanx of hand (HP:0009999)1.94648703
74Encephalitis (HP:0002383)1.94396048
75Autoimmune hemolytic anemia (HP:0001890)1.92393157
76Generalized aminoaciduria (HP:0002909)1.92332295
77Recurrent fungal infections (HP:0002841)1.91426360
78Arterial thrombosis (HP:0004420)1.87499858
79Duplication of thumb phalanx (HP:0009942)1.87041848
80Fused cervical vertebrae (HP:0002949)1.86398027
81Unsteady gait (HP:0002317)1.85100631
82Xerostomia (HP:0000217)1.83267054
83Abnormal number of erythroid precursors (HP:0012131)1.82407384
84Meningitis (HP:0001287)1.81094390
85Hepatosplenomegaly (HP:0001433)1.80420512
86Decreased activity of mitochondrial respiratory chain (HP:0008972)1.80179793
87Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.80179793
88IgG deficiency (HP:0004315)1.79025000
89Spontaneous hematomas (HP:0007420)1.78763401
90Femoral bowing (HP:0002980)1.78258791
91Reticulocytopenia (HP:0001896)1.77231723
92Hyperparathyroidism (HP:0000843)1.76554719
93Peripheral hypomyelination (HP:0007182)1.74652688
94Ureteral obstruction (HP:0006000)1.71127033
95IgA deficiency (HP:0002720)1.68823760
96Rimmed vacuoles (HP:0003805)1.67067843
97Aplasia of the musculature (HP:0100854)1.66756078
98Recurrent gram-negative bacterial infections (HP:0005420)1.65164228
99Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.64645613
100Gastrointestinal stroma tumor (HP:0100723)1.64391167

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.90305478
2PKN23.96256398
3SIK23.49081253
4MAP3K143.21593481
5NME22.92992208
6TESK12.92035688
7DDR22.63965156
8FLT32.47335080
9GRK72.42259254
10BMPR22.18833101
11MAP3K92.15622447
12BLK1.99048063
13IKBKB1.98998158
14RIPK41.97485147
15CHUK1.93768937
16MATK1.85514516
17DYRK31.78292424
18TAOK21.62644137
19CCNB11.62404458
20CDK31.58839788
21TBK11.55257109
22MOS1.49750781
23IRAK41.42493130
24LIMK11.41502598
25TYK21.38421274
26PIM21.37092413
27IKBKE1.36247591
28TAF11.30182710
29MAP3K131.28951697
30MAP2K21.25135368
31LATS21.16801143
32FGR1.15019119
33CSK1.12641399
34PRKG21.08742859
35SYK1.07619861
36STK101.06981499
37DYRK1B0.99227521
38PRPF4B0.96171878
39PAK40.94296980
40RPS6KC10.93724190
41RPS6KL10.93724190
42TAOK30.93583921
43CDK60.91660761
44RPS6KA40.91219204
45CDK80.89057181
46SMG10.87670491
47INSRR0.86153923
48CDC42BPA0.85731849
49RPS6KA60.80315322
50CDK40.78788552
51NEK20.78147145
52LYN0.77388423
53MAPK70.76995735
54PDGFRA0.76660831
55MAPK40.76611432
56ZAK0.74099747
57RPS6KA20.71416211
58NEK90.70726005
59ARAF0.68680666
60ABL20.67952536
61ERN10.67496699
62JAK30.66286240
63MAP4K10.64986747
64CDK120.62629971
65CHEK20.60552566
66MAP3K30.59813777
67SRPK10.54239714
68TLK10.53713662
69ADRBK20.53675405
70DAPK30.53259503
71ICK0.49827459
72BTK0.46077854
73JAK10.45371567
74BRAF0.45336189
75PKN10.44843209
76TXK0.42486263
77CSF1R0.41710679
78TGFBR20.40886252
79IRAK20.40666971
80TTN0.39868091
81EPHA30.39542365
82KDR0.39300109
83TAOK10.38995675
84PAK20.37994583
85AURKB0.37412206
86TESK20.37250419
87LCK0.36619948
88EGFR0.36433044
89MAP3K50.36015026
90LRRK20.35492278
91PASK0.35236437
92HIPK20.34342337
93TNIK0.33508308
94MAP3K80.33493955
95EPHB10.32287652
96MAP3K40.32166665
97DAPK20.31335576
98ERBB30.30924183
99CLK10.30706610
100NEK60.30147108

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053302.93016464
2Toll-like receptor signaling pathway_Homo sapiens_hsa046202.88431609
3Legionellosis_Homo sapiens_hsa051342.73038371
4Leishmaniasis_Homo sapiens_hsa051402.69228858
5Asthma_Homo sapiens_hsa053102.63009788
6Malaria_Homo sapiens_hsa051442.55599836
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.55227489
8Rheumatoid arthritis_Homo sapiens_hsa053232.54852030
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.52956075
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.42767328
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.42122098
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.37071842
13TNF signaling pathway_Homo sapiens_hsa046682.35314059
14Graft-versus-host disease_Homo sapiens_hsa053322.32544032
15Osteoclast differentiation_Homo sapiens_hsa043802.23874669
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.21076765
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.14493410
18African trypanosomiasis_Homo sapiens_hsa051432.13486316
19Influenza A_Homo sapiens_hsa051642.00932536
20Autoimmune thyroid disease_Homo sapiens_hsa053201.90512097
21Ribosome_Homo sapiens_hsa030101.89793997
22Pertussis_Homo sapiens_hsa051331.81144918
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.80882149
24Type I diabetes mellitus_Homo sapiens_hsa049401.78892217
25Toxoplasmosis_Homo sapiens_hsa051451.77705408
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.66464327
27Tuberculosis_Homo sapiens_hsa051521.64106281
28Antigen processing and presentation_Homo sapiens_hsa046121.62824831
29Staphylococcus aureus infection_Homo sapiens_hsa051501.61736649
30Measles_Homo sapiens_hsa051621.59265213
31Herpes simplex infection_Homo sapiens_hsa051681.48080652
32Salmonella infection_Homo sapiens_hsa051321.47413322
33Hematopoietic cell lineage_Homo sapiens_hsa046401.46521048
34Primary immunodeficiency_Homo sapiens_hsa053401.39029579
35Shigellosis_Homo sapiens_hsa051311.36487261
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35353175
37Viral myocarditis_Homo sapiens_hsa054161.33747417
38B cell receptor signaling pathway_Homo sapiens_hsa046621.33489336
39Bladder cancer_Homo sapiens_hsa052191.27293566
40Hepatitis B_Homo sapiens_hsa051611.18750525
41Phagosome_Homo sapiens_hsa041451.16801917
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.14237441
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10393523
44Lysosome_Homo sapiens_hsa041421.00464614
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97320137
46Oxidative phosphorylation_Homo sapiens_hsa001900.96879289
47Chemokine signaling pathway_Homo sapiens_hsa040620.92842397
48Notch signaling pathway_Homo sapiens_hsa043300.92124186
49Amoebiasis_Homo sapiens_hsa051460.90375996
50T cell receptor signaling pathway_Homo sapiens_hsa046600.87444800
51Apoptosis_Homo sapiens_hsa042100.85451691
52Epstein-Barr virus infection_Homo sapiens_hsa051690.85065204
53Hepatitis C_Homo sapiens_hsa051600.81248380
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.76718464
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76161615
56Parkinsons disease_Homo sapiens_hsa050120.72617318
57Prion diseases_Homo sapiens_hsa050200.71318883
58Alzheimers disease_Homo sapiens_hsa050100.70788044
59Prolactin signaling pathway_Homo sapiens_hsa049170.66125214
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66034233
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62458554
62HTLV-I infection_Homo sapiens_hsa051660.62192289
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61579237
64Other glycan degradation_Homo sapiens_hsa005110.59924983
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55875663
66Small cell lung cancer_Homo sapiens_hsa052220.55593317
67Nicotine addiction_Homo sapiens_hsa050330.55257894
68Systemic lupus erythematosus_Homo sapiens_hsa053220.53766456
69Acute myeloid leukemia_Homo sapiens_hsa052210.50682713
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49971357
71Viral carcinogenesis_Homo sapiens_hsa052030.49509427
72HIF-1 signaling pathway_Homo sapiens_hsa040660.47081943
73Type II diabetes mellitus_Homo sapiens_hsa049300.38455490
74Renin-angiotensin system_Homo sapiens_hsa046140.37406003
75Spliceosome_Homo sapiens_hsa030400.37070701
76MAPK signaling pathway_Homo sapiens_hsa040100.33679981
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32594237
78N-Glycan biosynthesis_Homo sapiens_hsa005100.32350733
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.31902114
80Fructose and mannose metabolism_Homo sapiens_hsa000510.28922725
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28625438
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28102289
83Huntingtons disease_Homo sapiens_hsa050160.25462740
84Pathways in cancer_Homo sapiens_hsa052000.19214375
85MicroRNAs in cancer_Homo sapiens_hsa052060.18918994
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.18242101
87DNA replication_Homo sapiens_hsa030300.17717467
88Chronic myeloid leukemia_Homo sapiens_hsa052200.16156975
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.15771161
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.13584777
91Protein export_Homo sapiens_hsa030600.12708637
92Proteoglycans in cancer_Homo sapiens_hsa052050.11411829
93VEGF signaling pathway_Homo sapiens_hsa043700.10749454
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.10641980
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.09789244
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.09090951
97Cardiac muscle contraction_Homo sapiens_hsa042600.08680874
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.08485362
99Nucleotide excision repair_Homo sapiens_hsa034200.07388159
100Basal cell carcinoma_Homo sapiens_hsa052170.06425875

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