HKDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the hexokinase protein family. The encoded protein is involved in glucose metabolism, and reduced expression may be associated with gestational diabetes mellitus. High expression of this gene may also be associated with poor prognosis in hepatocarcinoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.32579568
2vitamin A metabolic process (GO:0006776)7.15671406
3polyketide metabolic process (GO:0030638)6.55325561
4doxorubicin metabolic process (GO:0044598)6.55325561
5daunorubicin metabolic process (GO:0044597)6.55325561
6actin filament depolymerization (GO:0030042)6.04232035
7adhesion of symbiont to host cell (GO:0044650)5.92209592
8virion attachment to host cell (GO:0019062)5.92209592
9cellular glucuronidation (GO:0052695)5.91113434
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.87070523
11aminoglycoside antibiotic metabolic process (GO:0030647)5.80971570
12regulation of bile acid biosynthetic process (GO:0070857)5.80894323
13phospholipid efflux (GO:0033700)5.70539204
14uronic acid metabolic process (GO:0006063)5.65755474
15glucuronate metabolic process (GO:0019585)5.65755474
16digestive system process (GO:0022600)5.59200183
17flavonoid metabolic process (GO:0009812)5.56385100
18epoxygenase P450 pathway (GO:0019373)5.50409953
19plasma lipoprotein particle assembly (GO:0034377)5.48529513
20regulation of cholesterol esterification (GO:0010872)5.43848919
21modified amino acid transport (GO:0072337)5.35734113
22positive regulation of lipoprotein lipase activity (GO:0051006)5.34935774
23positive regulation of triglyceride lipase activity (GO:0061365)5.34935774
24drug catabolic process (GO:0042737)5.33695436
25protein-lipid complex assembly (GO:0065005)5.23761738
26lipoprotein metabolic process (GO:0042157)5.11590057
27urea metabolic process (GO:0019627)5.06575171
28regulation of triglyceride catabolic process (GO:0010896)5.00010826
29urea cycle (GO:0000050)4.98548934
30cholesterol efflux (GO:0033344)4.94264053
31digestion (GO:0007586)4.80260493
32adhesion of symbiont to host (GO:0044406)4.74660470
333-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.70745970
34purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.70745970
35very-low-density lipoprotein particle assembly (GO:0034379)4.69206273
36lipoprotein transport (GO:0042953)4.68844061
37hormone catabolic process (GO:0042447)4.66567741
38UDP-N-acetylglucosamine metabolic process (GO:0006047)4.65989488
39intestinal epithelial cell development (GO:0060576)4.61417891
40nitrogen cycle metabolic process (GO:0071941)4.60554596
41drug metabolic process (GO:0017144)4.58387221
42fat-soluble vitamin biosynthetic process (GO:0042362)4.55778738
43primary alcohol catabolic process (GO:0034310)4.52001683
44glycoside metabolic process (GO:0016137)4.47257489
45peptide catabolic process (GO:0043171)4.38165029
46bundle of His cell to Purkinje myocyte communication (GO:0086069)4.32213664
47cholesterol homeostasis (GO:0042632)4.29826974
48response to hepatocyte growth factor (GO:0035728)4.24814778
49cellular response to hepatocyte growth factor stimulus (GO:0035729)4.24814778
50sterol homeostasis (GO:0055092)4.24670103
51peptide hormone processing (GO:0016486)4.23105173
52sterol transport (GO:0015918)4.17652619
53cholesterol transport (GO:0030301)4.17652619
54sulfate transmembrane transport (GO:1902358)4.13796910
55diacylglycerol metabolic process (GO:0046339)4.12392116
56reverse cholesterol transport (GO:0043691)4.09033426
57drinking behavior (GO:0042756)4.03492615
58negative regulation of sterol transport (GO:0032372)3.99367532
59negative regulation of cholesterol transport (GO:0032375)3.99367532
60drug transmembrane transport (GO:0006855)3.98453824
61sulfur compound transport (GO:0072348)3.90144559
62bicarbonate transport (GO:0015701)3.90090385
63bile acid metabolic process (GO:0008206)3.89607779
64oligosaccharide catabolic process (GO:0009313)3.86641322
65NADH metabolic process (GO:0006734)3.83109330
66positive regulation of fatty acid biosynthetic process (GO:0045723)3.75870804
67purine nucleotide salvage (GO:0032261)3.68357112
68regulation of cholesterol homeostasis (GO:2000188)3.66100200
69ethanol oxidation (GO:0006069)3.65612029
70bile acid and bile salt transport (GO:0015721)3.65250616
71high-density lipoprotein particle remodeling (GO:0034375)3.61685721
72exogenous drug catabolic process (GO:0042738)3.60995270
73glutamine family amino acid biosynthetic process (GO:0009084)3.56410079
74plasma lipoprotein particle remodeling (GO:0034369)3.55805647
75protein-lipid complex remodeling (GO:0034368)3.55805647
76macromolecular complex remodeling (GO:0034367)3.55805647
77sulfate transport (GO:0008272)3.46209984
78arginine metabolic process (GO:0006525)3.45926767
79alkaloid metabolic process (GO:0009820)3.45163854
80maintenance of gastrointestinal epithelium (GO:0030277)3.45052165
81transepithelial transport (GO:0070633)3.42418247
82regulation of protein activation cascade (GO:2000257)3.41781553
83plasma lipoprotein particle organization (GO:0071827)3.39553087
84phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.39148062
85protein-lipid complex subunit organization (GO:0071825)3.38654148
86phenylpropanoid metabolic process (GO:0009698)3.33179139
87sulfation (GO:0051923)3.29563746
88fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.28874288
89regulation of systemic arterial blood pressure by hormone (GO:0001990)3.26468466
90regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.26468466
91endocrine process (GO:0050886)3.26468466
92complement activation, classical pathway (GO:0006958)3.26254188
93regulation of complement activation (GO:0030449)3.26053354
94regulation of actin nucleation (GO:0051125)3.24967694
95proline metabolic process (GO:0006560)3.24773678
96receptor guanylyl cyclase signaling pathway (GO:0007168)3.23032406
97L-phenylalanine metabolic process (GO:0006558)3.20706807
98erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.20706807
99sperm capacitation (GO:0048240)3.20619138
100positive regulation of pseudopodium assembly (GO:0031274)3.19200386
101transcytosis (GO:0045056)3.19172469
102negative regulation of fibrinolysis (GO:0051918)3.19002982
103regulation of lipoprotein metabolic process (GO:0050746)3.18236388
104positive regulation of triglyceride metabolic process (GO:0090208)3.17016312
105positive regulation of lipid catabolic process (GO:0050996)3.15519578
106regulation of digestive system process (GO:0044058)3.14220949
107fructose metabolic process (GO:0006000)3.13939592
108sphingomyelin metabolic process (GO:0006684)3.12631530
109regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.12137309
110renal system process involved in regulation of blood volume (GO:0001977)3.12065483
111negative regulation of digestive system process (GO:0060457)3.10583189
112thyroid hormone metabolic process (GO:0042403)3.09619287
113regulation of cellular extravasation (GO:0002691)3.09059856
114regulation of cardioblast differentiation (GO:0051890)3.07852862
115response to hydroperoxide (GO:0033194)3.07547713
116ethanol metabolic process (GO:0006067)3.03841285
117hemidesmosome assembly (GO:0031581)3.03587452
118low-density lipoprotein particle remodeling (GO:0034374)3.03565655
119positive regulation of T cell differentiation in thymus (GO:0033089)3.03250892
120cellular carbohydrate catabolic process (GO:0044275)3.03057184
121antibacterial humoral response (GO:0019731)3.02633854
122regulation of systemic arterial blood pressure (GO:0003073)3.00591946
123positive regulation of guanylate cyclase activity (GO:0031284)2.98734994
124cyclooxygenase pathway (GO:0019371)2.98455737
125regulation of vitamin metabolic process (GO:0030656)2.98100610
126lipid homeostasis (GO:0055088)2.97624440
127phospholipid homeostasis (GO:0055091)2.97312808
128regulation of cholesterol metabolic process (GO:0090181)2.97038389
129antimicrobial humoral response (GO:0019730)2.96338222
130trophectodermal cell differentiation (GO:0001829)2.96334947
131regulation of guanylate cyclase activity (GO:0031282)2.94343401
132calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.91697707
133innate immune response in mucosa (GO:0002227)2.89691882
134citrulline biosynthetic process (GO:0019240)2.89234740
135negative regulation of sodium ion transport (GO:0010766)2.88908625
136drug transport (GO:0015893)2.88526964
137homocysteine metabolic process (GO:0050667)2.87902191
138regulation of Golgi to plasma membrane protein transport (GO:0042996)2.87283080
139vitamin transport (GO:0051180)2.86216990
140O-glycan processing (GO:0016266)2.86165790
141progesterone metabolic process (GO:0042448)2.86069055
142quinone metabolic process (GO:1901661)2.85734106
143regulation of fibrinolysis (GO:0051917)2.84447334
144renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.84268507
145desmosome organization (GO:0002934)2.82925273
146vitamin transmembrane transport (GO:0035461)2.82513396
147negative regulation of coagulation (GO:0050819)2.81502216
148negative regulation of hemostasis (GO:1900047)2.81445526
149negative regulation of blood coagulation (GO:0030195)2.81445526
150intestinal absorption (GO:0050892)12.8211258
151intestinal cholesterol absorption (GO:0030299)12.3265395
152angiotensin maturation (GO:0002003)11.1036900

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.70302541
2* CDX2_20551321_ChIP-Seq_CACO-2_Human5.25158403
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.93936162
4HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.43130503
5* GATA4_25053715_ChIP-Seq_YYC3_Human3.22589759
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.05994229
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.99559885
8* GATA6_25053715_ChIP-Seq_YYC3_Human2.84940729
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.76619084
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.59494874
11* SOX2_20726797_ChIP-Seq_SW620_Human2.45566591
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.39076615
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.31578075
14SRY_22984422_ChIP-ChIP_TESTIS_Rat2.27079145
15* PPAR_26484153_Chip-Seq_NCI-H1993_Human2.23905658
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.21245145
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20176731
18ZNF263_19887448_ChIP-Seq_K562_Human2.11652272
19NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.10075526
20SALL4_18804426_ChIP-ChIP_XEN_Mouse1.91636568
21KLF5_25053715_ChIP-Seq_YYC3_Human1.91461084
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.87978368
23CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.82325711
24RUNX1_27514584_Chip-Seq_MCF-7_Human1.76893270
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.76095143
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.73342365
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.68857252
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.68361673
29AR_21909140_ChIP-Seq_LNCAP_Human1.65128894
30* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65083956
31ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.65026616
32TCF4_18268006_ChIP-ChIP_LS174T_Human1.61874887
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.60584609
34ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.59436700
35* RACK7_27058665_Chip-Seq_MCF-7_Human1.57129912
36ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.56983537
37* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.55865828
38CLOCK_20551151_ChIP-Seq_293T_Human1.55031421
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53357871
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52419446
41* ATF3_27146783_Chip-Seq_COLON_Human1.51703010
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.48656500
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47563729
44TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.45764557
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45033153
46* HNF4A_19822575_ChIP-Seq_HepG2_Human1.44926411
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44289551
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.42967801
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.42797035
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41235836
51SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.40989271
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40429336
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.39036108
54ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.38427808
55GATA2_19941826_ChIP-Seq_K562_Human1.32621934
56CREB1_26743006_Chip-Seq_LNCaP_Human1.29192618
57FOXA2_19822575_ChIP-Seq_HepG2_Human1.28889227
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.24604016
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23370380
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21442333
61P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20256990
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18652469
63TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18233666
64* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15956249
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15523406
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15081810
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14227820
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13028801
69SMAD3_21741376_ChIP-Seq_HESCs_Human1.11322628
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10887547
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.09431320
72GATA1_22025678_ChIP-Seq_K562_Human1.08576418
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08331942
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07872813
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.07253528
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.07011131
77AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06685059
78PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05279199
79CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05157924
80FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04067251
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03491620
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03291174
83* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02253255
84BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02145541
85LXR_22292898_ChIP-Seq_THP-1_Human1.00443434
86FOXA1_25552417_ChIP-Seq_VCAP_Human0.99702173
87FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97838292
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96187314
89DROSHA_22980978_ChIP-Seq_HELA_Human0.95130823
90JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93859333
91CJUN_26792858_Chip-Seq_BT549_Human0.92924904
92CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91710080
93EGR1_19032775_ChIP-ChIP_M12_Human0.91123118
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90870047
95GATA1_19941826_ChIP-Seq_K562_Human0.90385802
96SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88883618
97BCOR_27268052_Chip-Seq_Bcells_Human0.88882683
98RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88612592
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.88567364
100TP63_22573176_ChIP-Seq_HFKS_Human0.88450619
101GATA3_24758297_ChIP-Seq_MCF-7_Human0.87863619
102TCF3_18692474_ChIP-Seq_MESCs_Mouse0.86385986
103SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85540471
104SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84976185
105* CTCF_27219007_Chip-Seq_Bcells_Human0.84664474
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.84328262
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.84328262
108SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81697940
109PHF8_20622854_ChIP-Seq_HELA_Human0.81428527
110JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.80145165
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79863047
112STAT6_21828071_ChIP-Seq_BEAS2B_Human0.78954118
113* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78952116
114NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78055396
115NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.77825119
116EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77369966
117OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77328021
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.76262428
119RARA_24833708_ChIP-Seq_LIVER_Mouse0.76058317
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.74451162
121FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.73953811
122P68_20966046_ChIP-Seq_HELA_Human0.73808908
123TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.73792676
124SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72903582
125BCL6_27268052_Chip-Seq_Bcells_Human0.72512093
126* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.72072648

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.04635452
2MP0001666_abnormal_nutrient_absorption6.47538655
3MP0009840_abnormal_foam_cell4.47397682
4MP0004264_abnormal_extraembryonic_tissu4.19944820
5MP0010234_abnormal_vibrissa_follicle3.87114916
6MP0002139_abnormal_hepatobiliary_system3.55954108
7MP0003183_abnormal_peptide_metabolism3.37662832
8MP0000462_abnormal_digestive_system3.18050691
9MP0005085_abnormal_gallbladder_physiolo3.11835750
10MP0010329_abnormal_lipoprotein_level2.74235373
11MP0008875_abnormal_xenobiotic_pharmacok2.64158964
12MP0003252_abnormal_bile_duct2.60620429
13MP0003866_abnormal_defecation2.60482094
14MP0002138_abnormal_hepatobiliary_system2.59500239
15MP0005084_abnormal_gallbladder_morpholo2.57754650
16MP0003878_abnormal_ear_physiology2.41609573
17MP0005377_hearing/vestibular/ear_phenot2.41609573
18MP0002822_catalepsy2.41435301
19MP0004019_abnormal_vitamin_homeostasis2.38702890
20MP0000537_abnormal_urethra_morphology2.18849938
21MP0005365_abnormal_bile_salt2.03831373
22MP0004147_increased_porphyrin_level1.91131968
23MP0010352_gastrointestinal_tract_polyps1.87816357
24MP0005409_darkened_coat_color1.86000140
25MP0001664_abnormal_digestion1.78441017
26MP0005381_digestive/alimentary_phenotyp1.70763531
27MP0001663_abnormal_digestive_system1.65877795
28MP0004043_abnormal_pH_regulation1.65244265
29MP0003705_abnormal_hypodermis_morpholog1.61644771
30MP0000477_abnormal_intestine_morphology1.54230022
31MP0010155_abnormal_intestine_physiology1.49694024
32MP0000538_abnormal_urinary_bladder1.47807393
33MP0001873_stomach_inflammation1.41772451
34MP0009384_cardiac_valve_regurgitation1.41157774
35MP0005448_abnormal_energy_balance1.39544925
36MP0000490_abnormal_crypts_of1.39256031
37MP0003283_abnormal_digestive_organ1.35668153
38MP0003191_abnormal_cellular_cholesterol1.35473338
39MP0005058_abnormal_lysosome_morphology1.31968913
40MP0003195_calcinosis1.29611074
41MP0002796_impaired_skin_barrier1.29343226
42MP0005670_abnormal_white_adipose1.18767426
43MP0002089_abnormal_postnatal_growth/wei1.18582987
44MP0006054_spinal_hemorrhage1.16650501
45MP0003300_gastrointestinal_ulcer1.10719008
46MP0003693_abnormal_embryo_hatching1.08314542
47MP0009780_abnormal_chondrocyte_physiolo1.08092383
48MP0004270_analgesia1.07567383
49MP0009643_abnormal_urine_homeostasis1.07040592
50MP0003718_maternal_effect1.05787413
51MP0002254_reproductive_system_inflammat1.05217815
52MP0005332_abnormal_amino_acid1.03851497
53MP0005167_abnormal_blood-brain_barrier1.03841672
54MP0005584_abnormal_enzyme/coenzyme_acti1.03543321
55MP0002118_abnormal_lipid_homeostasis1.02844322
56MP0000678_abnormal_parathyroid_gland1.01873339
57MP0003806_abnormal_nucleotide_metabolis1.01401658
58MP0003119_abnormal_digestive_system0.98873881
59MP0003941_abnormal_skin_development0.98391920
60MP0003879_abnormal_hair_cell0.96981637
61MP0009697_abnormal_copulation0.96791454
62MP0001849_ear_inflammation0.96748770
63MP0005023_abnormal_wound_healing0.93527569
64MP0003315_abnormal_perineum_morphology0.90063306
65MP0005408_hypopigmentation0.88460302
66MP0010678_abnormal_skin_adnexa0.86633387
67MP0000609_abnormal_liver_physiology0.84612556
68MP0009053_abnormal_anal_canal0.82124086
69MP0000467_abnormal_esophagus_morphology0.80772199
70MP0009379_abnormal_foot_pigmentation0.80058051
71MP0008469_abnormal_protein_level0.79387484
72MP0008872_abnormal_physiological_respon0.78388330
73MP0002971_abnormal_brown_adipose0.78061708
74MP0004272_abnormal_basement_membrane0.76981534
75MP0005367_renal/urinary_system_phenotyp0.76226535
76MP0000516_abnormal_urinary_system0.76226535
77MP0004858_abnormal_nervous_system0.75953663
78MP0005501_abnormal_skin_physiology0.74096522
79MP0001765_abnormal_ion_homeostasis0.74008081
80MP0000566_synostosis0.73855562
81MP0002098_abnormal_vibrissa_morphology0.72373027
82MP0001764_abnormal_homeostasis0.69241020
83MP0005266_abnormal_metabolism0.69000485
84MP0003950_abnormal_plasma_membrane0.68486088
85MP0001845_abnormal_inflammatory_respons0.67568598
86MP0005166_decreased_susceptibility_to0.66459379
87MP0005083_abnormal_biliary_tract0.66021488
88MP0004947_skin_inflammation0.65598229
89MP0005666_abnormal_adipose_tissue0.63433151
90MP0005164_abnormal_response_to0.63009065
91MP0003436_decreased_susceptibility_to0.62869235
92MP0002876_abnormal_thyroid_physiology0.62771457
93MP0000249_abnormal_blood_vessel0.62074512
94MP0000598_abnormal_liver_morphology0.61549181
95MP0003566_abnormal_cell_adhesion0.60873208
96MP0002896_abnormal_bone_mineralization0.60110576
97MP0009785_altered_susceptibility_to0.58809221
98MP0008260_abnormal_autophagy0.58807222
99MP0002136_abnormal_kidney_physiology0.58286232
100MP0009333_abnormal_splenocyte_physiolog0.57970360
101MP0006138_congestive_heart_failure0.57878129
102MP0000858_altered_metastatic_potential0.57761307
103MP0003868_abnormal_feces_composition0.57132532
104MP0005636_abnormal_mineral_homeostasis0.57045046
105MP0010386_abnormal_urinary_bladder0.56492008
106MP0005165_increased_susceptibility_to0.55897394
107MP0008004_abnormal_stomach_pH0.54205916
108MP0002166_altered_tumor_susceptibility0.53572512
109MP0003453_abnormal_keratinocyte_physiol0.53130988
110MP0005257_abnormal_intraocular_pressure0.53066973
111MP0004782_abnormal_surfactant_physiolog0.52529328
112MP0001881_abnormal_mammary_gland0.52164010
113MP0003638_abnormal_response/metabolism_0.51903048
114MP0009115_abnormal_fat_cell0.51614338
115MP0003091_abnormal_cell_migration0.51264569
116MP0005376_homeostasis/metabolism_phenot0.51183794
117MP0004957_abnormal_blastocyst_morpholog0.51005016
118MP0005076_abnormal_cell_differentiation0.50336612
119MP0000470_abnormal_stomach_morphology0.49305281
120MP0004885_abnormal_endolymph0.48548579
121MP0005319_abnormal_enzyme/_coenzyme0.47456158
122MP0001216_abnormal_epidermal_layer0.45743610
123MP0005451_abnormal_body_composition0.45507189
124MP0002277_abnormal_respiratory_mucosa0.42272047
125MP0009642_abnormal_blood_homeostasis0.42113411
126MP0001730_embryonic_growth_arrest0.42003137
127MP0000604_amyloidosis0.40044107
128MP0001756_abnormal_urination0.39253593
129MP0003115_abnormal_respiratory_system0.38752079
130MP0001191_abnormal_skin_condition0.35939593
131MP0001440_abnormal_grooming_behavior0.35737314
132MP0009765_abnormal_xenobiotic_induced0.34982115
133MP0003329_amyloid_beta_deposits0.33444019

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)9.03097538
2Acanthocytosis (HP:0001927)7.30321008
3Abnormality of glutamine family amino acid metabolism (HP:0010902)7.04322394
4Hypobetalipoproteinemia (HP:0003563)7.02845802
5Malnutrition (HP:0004395)5.86996560
6Hydroxyprolinuria (HP:0003080)5.59295838
7Abnormality of proline metabolism (HP:0010907)5.59295838
8Conjugated hyperbilirubinemia (HP:0002908)4.85926029
9Autoimmune thrombocytopenia (HP:0001973)4.85379768
10Right ventricular cardiomyopathy (HP:0011663)4.76331785
11Pigmentary retinal degeneration (HP:0001146)4.53007103
12Systemic lupus erythematosus (HP:0002725)4.51539054
13Cupped ribs (HP:0000887)4.29979558
14Fat malabsorption (HP:0002630)4.27391631
15Poikilocytosis (HP:0004447)4.21512799
16Deep venous thrombosis (HP:0002625)4.18101040
17Hypolipoproteinemia (HP:0010981)4.07360835
18Abnormality of the vitamin B12 metabolism (HP:0004341)3.98179757
19Widely patent fontanelles and sutures (HP:0004492)3.94149235
20Complement deficiency (HP:0004431)3.79816653
21Abnormality of vitamin B metabolism (HP:0004340)3.73531783
22Autoimmune hemolytic anemia (HP:0001890)3.70840407
23Hemorrhage of the eye (HP:0011885)3.64531502
24Abdominal distention (HP:0003270)3.60140105
25Abnormality of complement system (HP:0005339)3.56752253
26Chronic diarrhea (HP:0002028)3.54221002
27Focal segmental glomerulosclerosis (HP:0000097)3.51444530
28Gastrointestinal dysmotility (HP:0002579)3.35375366
29Hyperglycinuria (HP:0003108)3.32900723
30Glomerulonephritis (HP:0000099)3.30777083
31Abnormality of urine glucose concentration (HP:0011016)3.30269114
32Glycosuria (HP:0003076)3.30269114
33Facial shape deformation (HP:0011334)3.18319248
34Potter facies (HP:0002009)3.18319248
35Confusion (HP:0001289)3.15797198
36Abnormality of vitamin metabolism (HP:0100508)3.12175905
37Steatorrhea (HP:0002570)3.08491769
38Abnormality of aromatic amino acid family metabolism (HP:0004338)3.06999827
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.05908910
40Abnormality of pyrimidine metabolism (HP:0004353)3.04404289
41Xanthomatosis (HP:0000991)2.99029572
42Megaloblastic anemia (HP:0001889)2.97041637
43Glomerulosclerosis (HP:0000096)2.90866858
44Abnormality of the 1st metacarpal (HP:0010009)2.87754794
45Hyperammonemia (HP:0001987)2.86057224
46Mesangial abnormality (HP:0001966)2.83226479
47Dehydration (HP:0001944)2.81565132
48Prolonged partial thromboplastin time (HP:0003645)2.79513624
49Abnormal glucose tolerance (HP:0001952)2.78189544
50Nephritis (HP:0000123)2.75355571
51Pustule (HP:0200039)2.75125611
52Progressive sensorineural hearing impairment (HP:0000408)2.72449744
53Nephrolithiasis (HP:0000787)2.71326310
54Wide cranial sutures (HP:0010537)2.69520656
55Mildly elevated creatine phosphokinase (HP:0008180)2.66121107
56Reticulocytosis (HP:0001923)2.65285620
57Polycythemia (HP:0001901)2.65248176
58Hypercholesterolemia (HP:0003124)2.64744384
59Gout (HP:0001997)2.64202445
60Abnormal biliary tract morphology (HP:0012440)2.62570588
61Vascular calcification (HP:0004934)2.62542854
62Abnormality of monocarboxylic acid metabolism (HP:0010996)2.57273904
63Increased purine levels (HP:0004368)2.52132233
64Hyperuricemia (HP:0002149)2.52132233
65Congenital sensorineural hearing impairment (HP:0008527)2.49958349
66Hypophosphatemia (HP:0002148)2.48874378
67Flat acetabular roof (HP:0003180)2.48000372
68Hyperphosphaturia (HP:0003109)2.40516191
69Increased IgE level (HP:0003212)2.38937767
70Abnormality of the gastric mucosa (HP:0004295)2.38519158
71Villous atrophy (HP:0011473)2.38015094
72Abnormality of small intestinal villus morphology (HP:0011472)2.38015094
73Alkalosis (HP:0001948)2.35391499
74Intrahepatic cholestasis (HP:0001406)2.35338999
75Abnormality of purine metabolism (HP:0004352)2.33284351
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.32950409
77Syncope (HP:0001279)2.30880861
78Rectal prolapse (HP:0002035)2.28552511
79Abnormality of the common coagulation pathway (HP:0010990)2.27524001
80Increased mean platelet volume (HP:0011877)2.27141159
81Abnormality of sulfur amino acid metabolism (HP:0004339)2.26725050
82Cardiovascular calcification (HP:0011915)2.26479159
83Abnormality of serine family amino acid metabolism (HP:0010894)2.26345825
84Abnormality of glycine metabolism (HP:0010895)2.26345825
85Progressive hearing impairment (HP:0001730)2.24497648
86Rickets (HP:0002748)2.22982194
87Abnormal tarsal ossification (HP:0008369)2.20956917
88Late onset (HP:0003584)2.20871645
89Hepatocellular carcinoma (HP:0001402)2.20111857
90Alopecia of scalp (HP:0002293)2.18839854
91Abnormality of alkaline phosphatase activity (HP:0004379)2.18445132
92Pili torti (HP:0003777)2.16082005
93Abnormal enzyme/coenzyme activity (HP:0012379)2.16047154
94Ventricular fibrillation (HP:0001663)2.13491048
95Cheilitis (HP:0100825)2.10535350
96Retinal atrophy (HP:0001105)2.10427824
97Severe combined immunodeficiency (HP:0004430)2.10281021
98Bundle branch block (HP:0011710)2.10096246
99Hypotension (HP:0002615)2.09403676
100B lymphocytopenia (HP:0010976)2.07175129
101Abnormality of B cell number (HP:0010975)2.07175129
102Woolly hair (HP:0002224)1.99692095
103Renal tubular acidosis (HP:0001947)1.99511478
104Combined immunodeficiency (HP:0005387)1.98159561
105Elevated alkaline phosphatase (HP:0003155)1.97567308
106Abnormal pancreas size (HP:0012094)1.97432900
107Abnormal urine phosphate concentration (HP:0012599)1.97180118
108Joint hemorrhage (HP:0005261)1.96921707
109Hyperbilirubinemia (HP:0002904)1.96839657
110Myopathic facies (HP:0002058)1.96486323
111Palpitations (HP:0001962)1.96016163
112Epidermoid cyst (HP:0200040)1.95997523
113Abnormal gallbladder physiology (HP:0012438)1.94035905
114Cholecystitis (HP:0001082)1.94035905
115Bone pain (HP:0002653)1.93891780
116Vertebral compression fractures (HP:0002953)1.92767011
117Metabolic acidosis (HP:0001942)1.91642647
118Subcapsular cataract (HP:0000523)1.90914432
119Thin bony cortex (HP:0002753)1.90685989
120Symptomatic seizures (HP:0011145)1.88445326
121Polygenic inheritance (HP:0010982)1.85969327
122Proximal tubulopathy (HP:0000114)1.85221835
123Nausea (HP:0002018)1.84253981
124Abnormal platelet volume (HP:0011876)1.83831374
125Hyperactive renin-angiotensin system (HP:0000841)1.83271789
126Short phalanx of the thumb (HP:0009660)1.81049420
127Paraparesis (HP:0002385)1.79729905
128Amyloidosis (HP:0011034)1.79388480
129Micronodular cirrhosis (HP:0001413)1.77217790
130Eczematoid dermatitis (HP:0000976)1.76635345
131Male infertility (HP:0003251)1.76433016
132Delayed epiphyseal ossification (HP:0002663)1.76304573
133Cone-rod dystrophy (HP:0000548)1.75627657
134Hyperlipoproteinemia (HP:0010980)1.75508171
135Abnormality of nucleobase metabolism (HP:0010932)1.75496284
136Fragile skin (HP:0001030)1.75153326
137Abnormality of carpal bone ossification (HP:0006257)1.74790317
138Milia (HP:0001056)1.74598943
139Hyperparathyroidism (HP:0000843)1.74105860
140Generalized aminoaciduria (HP:0002909)1.73994566
141Abnormality of the Achilles tendon (HP:0005109)1.73645554
142Vacuolated lymphocytes (HP:0001922)1.71657345
143Osteomalacia (HP:0002749)1.70722345
144Protuberant abdomen (HP:0001538)1.70416414
145Prolonged neonatal jaundice (HP:0006579)1.68802709
146Pancreatitis (HP:0001733)1.68776273
147Distal upper limb amyotrophy (HP:0007149)1.68157352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.01811018
2MST45.23075981
3LMTK25.18114641
4NME13.88404840
5MST1R3.83269809
6EPHA23.56913926
7PRKG23.43442605
8GRK63.40439937
9ACVR1B3.39028923
10AKT33.08836148
11RIPK12.76333628
12MAP2K22.39674375
13IRAK32.21926984
14MAP3K102.19248532
15MAP3K22.05449774
16PTK62.02893119
17DDR21.71949059
18EPHB21.68223316
19TAOK11.52664963
20ERN11.46770927
21PRKCI1.42784821
22NUAK11.41470590
23SIK11.37600883
24PRPF4B1.35460736
25MET1.31880510
26MAP3K91.30427768
27STK391.30264170
28TTK1.23247209
29TESK11.19157981
30KSR21.15399697
31MAP3K81.15208302
32STK101.13622758
33MATK1.12250011
34SCYL21.10281280
35TRIB31.09354399
36NEK11.06908339
37FGFR31.01644034
38PTK20.99651402
39EPHA30.98150554
40PIK3CA0.94266840
41FER0.94118732
42ERBB40.88888386
43PAK40.85982364
44TYK20.84849916
45ERBB20.84710397
46TESK20.80151343
47STK240.78310105
48RIPK40.78278204
49MAP2K10.78123778
50TYRO30.77839213
51PDPK10.77573465
52MYLK0.77305360
53LATS20.75159037
54MAP3K110.73902706
55MAP2K60.71851781
56ARAF0.67466934
57SMG10.66134097
58BMX0.65471637
59LATS10.65455941
60MAP3K30.65221386
61TBK10.63830091
62STK38L0.63101062
63PRKAA20.61282487
64MAP3K70.60245128
65MAP3K10.57750741
66BRAF0.56672729
67PAK30.55162841
68GRK10.54525874
69CASK0.53119717
70ICK0.52947979
71DAPK20.52756254
72IRAK10.52524944
73STK380.52018275
74ABL20.51093420
75OXSR10.50112834
76EPHB10.48958598
77AKT20.48657770
78PDK20.46367145
79PDGFRA0.46263970
80PRKAA10.44985674
81TAOK30.44902578
82NTRK10.44741426
83DMPK0.44595109
84PDK10.44042465
85MAPK110.43740187
86PAK10.41037984
87MAP3K140.40571764
88NLK0.40248707
89LRRK20.39867794
90STK110.39551024
91ZAP700.38703511
92NEK90.38325263
93YES10.38238419
94AURKB0.38214354
95PRKCA0.36928750
96CSF1R0.35770300
97CSNK1A10.34469690
98JAK10.34057800
99FGR0.33535311
100RET0.31755565
101KSR10.30833016
102CDK60.30408393
103IRAK40.30186789
104PIK3CG0.29935089
105EPHA40.29128034
106MAP4K10.28949358
107CDC42BPA0.28841120
108CDK40.28641480
109MAPKAPK20.28236467
110MELK0.27506398
111PDGFRB0.26448438
112NME20.25322800
113CAMKK10.25110172
114BMPR20.25020870
115IGF1R0.24786561
116FGFR40.24128698
117CAMK2D0.23361626
118PDK40.22152945
119PDK30.22152945
120SIK30.21294990
121ROCK10.21171858
122PIM20.20985046
123CDK50.20873221
124DAPK30.20816713
125SRC0.20498866
126CAMK2B0.20496224
127GSK3A0.20238839
128BCR0.20234084
129PRKACG0.20037037
130CSNK1E0.19925689
131FYN0.19615811
132FGFR10.18900346
133LIMK10.18900162
134STK30.18176405
135PAK20.17953334
136PBK0.17784532
137DYRK1B0.17664467
138CDK11A0.17583403
139MAP3K120.16993805
140CAMK2G0.15289284
141PRKCZ0.13879193

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049756.80591358
2Renin-angiotensin system_Homo sapiens_hsa046144.85848488
3Mineral absorption_Homo sapiens_hsa049784.69565220
4Vitamin digestion and absorption_Homo sapiens_hsa049774.67126727
5Caffeine metabolism_Homo sapiens_hsa002322.93003421
6Protein digestion and absorption_Homo sapiens_hsa049742.65871489
7Sulfur metabolism_Homo sapiens_hsa009202.52498391
8* Galactose metabolism_Homo sapiens_hsa000522.42368474
9Bile secretion_Homo sapiens_hsa049762.41611153
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.40749807
11Folate biosynthesis_Homo sapiens_hsa007902.38123715
12* Carbohydrate digestion and absorption_Homo sapiens_hsa049732.36348609
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.11521026
14* Starch and sucrose metabolism_Homo sapiens_hsa005001.90456433
15Histidine metabolism_Homo sapiens_hsa003401.86547356
16Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.86172570
17Complement and coagulation cascades_Homo sapiens_hsa046101.77907220
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.76022748
19Phenylalanine metabolism_Homo sapiens_hsa003601.63581629
20Glycerolipid metabolism_Homo sapiens_hsa005611.59650293
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.53983988
22Nitrogen metabolism_Homo sapiens_hsa009101.53248453
23* Fructose and mannose metabolism_Homo sapiens_hsa000511.41799935
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.41541127
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38552504
26Glutathione metabolism_Homo sapiens_hsa004801.34979663
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.33688222
28Sphingolipid metabolism_Homo sapiens_hsa006001.31062311
29PPAR signaling pathway_Homo sapiens_hsa033201.29508622
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25334610
31Arginine biosynthesis_Homo sapiens_hsa002201.24106486
32Arginine and proline metabolism_Homo sapiens_hsa003301.18187151
33Other glycan degradation_Homo sapiens_hsa005111.16037541
34Tryptophan metabolism_Homo sapiens_hsa003801.11255319
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.10950880
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10128468
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04545946
38Tight junction_Homo sapiens_hsa045300.99576113
39Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97519522
40Pancreatic secretion_Homo sapiens_hsa049720.96262761
41Glycerophospholipid metabolism_Homo sapiens_hsa005640.95551158
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94883389
43Tyrosine metabolism_Homo sapiens_hsa003500.93482209
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92113931
45Pentose phosphate pathway_Homo sapiens_hsa000300.90185532
46ABC transporters_Homo sapiens_hsa020100.89985483
47Fatty acid degradation_Homo sapiens_hsa000710.83018413
48Thyroid hormone synthesis_Homo sapiens_hsa049180.82713773
49* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81002314
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.76350857
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76033232
52Staphylococcus aureus infection_Homo sapiens_hsa051500.74198431
53Vitamin B6 metabolism_Homo sapiens_hsa007500.71714369
54Sulfur relay system_Homo sapiens_hsa041220.70327079
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68848528
56Pyruvate metabolism_Homo sapiens_hsa006200.63183361
57Gastric acid secretion_Homo sapiens_hsa049710.61089287
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59341403
59Biosynthesis of amino acids_Homo sapiens_hsa012300.57816598
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56639670
61* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54721716
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53120426
63* Carbon metabolism_Homo sapiens_hsa012000.52377023
64Salivary secretion_Homo sapiens_hsa049700.50081055
65beta-Alanine metabolism_Homo sapiens_hsa004100.46805458
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46166963
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46141139
68Insulin secretion_Homo sapiens_hsa049110.45047708
69Vibrio cholerae infection_Homo sapiens_hsa051100.39384032
70Retinol metabolism_Homo sapiens_hsa008300.38714557
71Bladder cancer_Homo sapiens_hsa052190.37966014
72Salmonella infection_Homo sapiens_hsa051320.36077906
73Linoleic acid metabolism_Homo sapiens_hsa005910.35944707
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.35751776
75Chemical carcinogenesis_Homo sapiens_hsa052040.35570696
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.35244860
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33818296
78Adherens junction_Homo sapiens_hsa045200.31669857
79Renin secretion_Homo sapiens_hsa049240.31338522
80African trypanosomiasis_Homo sapiens_hsa051430.30934938
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.30439277
82GnRH signaling pathway_Homo sapiens_hsa049120.29247312
83Arachidonic acid metabolism_Homo sapiens_hsa005900.28959406
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.28890351
85* Metabolic pathways_Homo sapiens_hsa011000.28384144
86Steroid biosynthesis_Homo sapiens_hsa001000.27736113
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26727886
88Pertussis_Homo sapiens_hsa051330.26165385
89Propanoate metabolism_Homo sapiens_hsa006400.26134613
90Thyroid cancer_Homo sapiens_hsa052160.25998852
91Inositol phosphate metabolism_Homo sapiens_hsa005620.24203865
92Prion diseases_Homo sapiens_hsa050200.24121542
93N-Glycan biosynthesis_Homo sapiens_hsa005100.23885508
94Lysine degradation_Homo sapiens_hsa003100.23477342
95Selenocompound metabolism_Homo sapiens_hsa004500.22700966
96Ether lipid metabolism_Homo sapiens_hsa005650.22237115
97Amoebiasis_Homo sapiens_hsa051460.21378518
98Hepatitis C_Homo sapiens_hsa051600.21120208
99Fatty acid elongation_Homo sapiens_hsa000620.18939255
100Gap junction_Homo sapiens_hsa045400.18548393
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18366067
102Butanoate metabolism_Homo sapiens_hsa006500.17495778
103Fatty acid biosynthesis_Homo sapiens_hsa000610.15066748
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13263441
105Glucagon signaling pathway_Homo sapiens_hsa049220.12958612
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.12212158
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.11944237
108Insulin resistance_Homo sapiens_hsa049310.11191242
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.09723303
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09569285
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.08939879
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.08901361
113Long-term depression_Homo sapiens_hsa047300.08313837
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.08152785
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.06001305
116Small cell lung cancer_Homo sapiens_hsa052220.05596594
117Choline metabolism in cancer_Homo sapiens_hsa052310.05299612
118Fatty acid metabolism_Homo sapiens_hsa012120.04627196
119Asthma_Homo sapiens_hsa053100.04211671
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.04024758
121Peroxisome_Homo sapiens_hsa041460.03783457
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.02949296
123VEGF signaling pathway_Homo sapiens_hsa043700.02011249
124Cocaine addiction_Homo sapiens_hsa050300.01341217

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