ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	leukocyte aggregation (GO:0070486)	9.26019230
2	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	8.70968448
3	glycoprotein catabolic process (GO:0006516)	8.51491080
4	rRNA transcription (GO:0009303)	7.35918632
5	positive regulation of signal transduction by p53 class mediator (GO:1901798)	6.85628093
6	macroautophagy (GO:0016236)	6.26990322
7	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)	5.77736757
8	positive regulation of vascular permeability (GO:0043117)	5.25221136
9	reciprocal DNA recombination (GO:0035825)	5.24243704
10	reciprocal meiotic recombination (GO:0007131)	5.24243704
11	meiotic chromosome segregation (GO:0045132)	5.17844427
12	induction of positive chemotaxis (GO:0050930)	5.12567672
13	myelin assembly (GO:0032288)	4.85177308
14	positive regulation of defense response to virus by host (GO:0002230)	4.65697650
15	resolution of meiotic recombination intermediates (GO:0000712)	4.48709429
16	spinal cord development (GO:0021510)	4.35727732
17	forebrain morphogenesis (GO:0048853)	4.28404054
18	nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)	4.28184928
19	piRNA metabolic process (GO:0034587)	4.22941022
20	erythrocyte maturation (GO:0043249)	4.18047676
21	chaperone-mediated protein transport (GO:0072321)	4.17212697
22	lateral ventricle development (GO:0021670)	4.12378810
23	hair cell differentiation (GO:0035315)	4.12168779
24	DNA deamination (GO:0045006)	4.11412004
25	epithelial cilium movement (GO:0003351)	3.96404540
26	cilium or flagellum-dependent cell motility (GO:0001539)	3.94106156
27	regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)	3.92835601
28	astrocyte differentiation (GO:0048708)	3.79742632
29	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.67078278
30	male meiosis I (GO:0007141)	3.63545137
31	metallo-sulfur cluster assembly (GO:0031163)	3.61973760
32	iron-sulfur cluster assembly (GO:0016226)	3.61973760
33	hematopoietic stem cell differentiation (GO:0060218)	3.52610840
34	DNA methylation involved in gamete generation (GO:0043046)	3.48989074
35	cilium movement (GO:0003341)	3.41454943
36	I-kappaB kinase/NF-kappaB signaling (GO:0007249)	3.39787006
37	protein targeting to lysosome (GO:0006622)	3.39194455
38	establishment of protein localization to vacuole (GO:0072666)	3.39194455
39	protein targeting to vacuole (GO:0006623)	3.39194455
40	heart morphogenesis (GO:0003007)	3.34156116
41	behavioral response to nicotine (GO:0035095)	3.33840936
42	maintenance of protein location in nucleus (GO:0051457)	3.31865973
43	gamma-aminobutyric acid transport (GO:0015812)	3.30517414
44	peroxisome organization (GO:0007031)	3.28126213
45	cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)	3.25796008
46	UV protection (GO:0009650)	3.22999197
47	synapsis (GO:0007129)	3.10882988
48	regulation of synapse maturation (GO:0090128)	3.08831822
49	peroxisome fission (GO:0016559)	3.05842600
50	response to pheromone (GO:0019236)	3.05780951
51	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.94780938
52	synaptonemal complex assembly (GO:0007130)	2.94100133
53	transcription from mitochondrial promoter (GO:0006390)	2.86712594
54	regulation of action potential (GO:0098900)	2.86589234
55	detection of light stimulus involved in visual perception (GO:0050908)	2.82423937
56	detection of light stimulus involved in sensory perception (GO:0050962)	2.82423937
57	positive regulation of monocyte chemotaxis (GO:0090026)	2.82200767
58	energy homeostasis (GO:0097009)	2.82199930
59	axonemal dynein complex assembly (GO:0070286)	2.78573483
60	protein polyglutamylation (GO:0018095)	2.78247479
61	positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)	2.78067660
62	positive regulation of positive chemotaxis (GO:0050927)	2.77665092
63	regulation of positive chemotaxis (GO:0050926)	2.72508890
64	regulation of cilium movement (GO:0003352)	2.71564420
65	pseudouridine synthesis (GO:0001522)	2.71059364
66	synaptonemal complex organization (GO:0070193)	2.69786560
67	glomerulus development (GO:0032835)	2.69157244
68	chromosome organization involved in meiosis (GO:0070192)	2.69092744
69	negative regulation of telomere maintenance (GO:0032205)	2.67757919
70	axoneme assembly (GO:0035082)	2.67535658
71	somite rostral/caudal axis specification (GO:0032525)	2.66699539
72	cellular ketone body metabolic process (GO:0046950)	2.66671271
73	histone H4-K12 acetylation (GO:0043983)	2.66047116
74	negative regulation of mast cell activation (GO:0033004)	2.65441306
75	meiosis I (GO:0007127)	2.64434144
76	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.62404808
77	NADH dehydrogenase complex assembly (GO:0010257)	2.62404808
78	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.62404808
79	regulation of mitotic spindle checkpoint (GO:1903504)	2.60439665
80	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.60439665
81	male meiosis (GO:0007140)	2.58600625
82	proline transport (GO:0015824)	2.58527260
83	myoblast migration (GO:0051451)	2.57647186
84	protein targeting to peroxisome (GO:0006625)	2.55313533
85	establishment of protein localization to peroxisome (GO:0072663)	2.55313533
86	protein localization to peroxisome (GO:0072662)	2.55313533
87	protein localization to vacuole (GO:0072665)	2.55206954
88	protein localization to lysosome (GO:0061462)	2.55206954
89	protein complex biogenesis (GO:0070271)	2.54123096
90	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.52603418
91	JNK cascade (GO:0007254)	2.49266313
92	neuronal action potential propagation (GO:0019227)	2.48442365
93	regulation of defense response to virus by host (GO:0050691)	2.48092685
94	cysteine metabolic process (GO:0006534)	2.47611130
95	early endosome to late endosome transport (GO:0045022)	2.45884420
96	astrocyte development (GO:0014002)	2.45727939
97	transcription from RNA polymerase I promoter (GO:0006360)	2.45302080
98	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.45112735
99	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.45112735
100	activation of MAPKKK activity (GO:0000185)	11.7858274

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.18048444
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.44140333
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.38481783
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.33389340
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.14018955
6	VDR_22108803_ChIP-Seq_LS180_Human	2.74089366
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.71399471
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.17171842
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.10234702
10	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.07062447
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.95123721
12	FUS_26573619_Chip-Seq_HEK293_Human	1.91596894
13	TP53_22573176_ChIP-Seq_HFKS_Human	1.88042015
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.87899940
15	TAF15_26573619_Chip-Seq_HEK293_Human	1.85689153
16	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.83628630
17	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.82551793
18	DROSHA_22980978_ChIP-Seq_HELA_Human	1.81399391
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.80263577
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.79324005
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.79211727
22	EWS_26573619_Chip-Seq_HEK293_Human	1.73157827
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.62441760
24	AR_20517297_ChIP-Seq_VCAP_Human	1.60891500
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.59925885
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.55936494
27	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.53504124
28	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.53504124
29	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.53171114
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.52111494
31	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.49538064
32	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.45966619
33	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.45885597
34	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.45531452
35	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.45057944
36	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.44874669
37	P300_19829295_ChIP-Seq_ESCs_Human	1.44144618
38	AR_25329375_ChIP-Seq_VCAP_Human	1.42724060
39	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.42670535
40	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.41169231
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40832470
42	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.37486967
43	REST_21632747_ChIP-Seq_MESCs_Mouse	1.36415242
44	STAT1_20625510_ChIP-Seq_HELA_Human	1.36026379
45	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.34602595
46	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.32428037
47	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.31447954
48	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30534432
49	NCOR_22424771_ChIP-Seq_293T_Human	1.30120513
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28909522
51	STAT3_23295773_ChIP-Seq_U87_Human	1.28874965
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.26546249
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.26546249
54	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.26273878
55	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.25840956
56	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.24987560
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24443709
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24203417
59	RNF2_27304074_Chip-Seq_NSC_Mouse	1.23565062
60	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.22736541
61	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.21856332
62	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.21326107
63	SMAD4_21799915_ChIP-Seq_A2780_Human	1.20719365
64	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.20401773
65	TP53_16413492_ChIP-PET_HCT116_Human	1.20305168
66	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.16805213
67	ERA_21632823_ChIP-Seq_H3396_Human	1.15699889
68	* TCF4_23295773_ChIP-Seq_U87_Human	1.14568631
69	MYC_19829295_ChIP-Seq_ESCs_Human	1.14440018
70	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.13838286
71	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.13058877
72	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.12759603
73	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.12462018
74	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.10401777
75	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.10325273
76	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09973757
77	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09973757
78	TAF2_19829295_ChIP-Seq_ESCs_Human	1.09260728
79	* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05726006
80	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.05225234
81	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.04942023
82	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.03214385
83	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03119121
84	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.03119121
85	AR_21572438_ChIP-Seq_LNCaP_Human	1.03114942
86	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.02526810
87	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.02170899
88	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.00902289
89	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00772254
90	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.00570748
91	CIITA_25753668_ChIP-Seq_RAJI_Human	1.00059686
92	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97117439
93	IRF1_19129219_ChIP-ChIP_H3396_Human	0.96699940
94	MYC_18940864_ChIP-ChIP_HL60_Human	0.96130867
95	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.95920711
96	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.95802031
97	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.93770063
98	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93333959
99	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.92984901
100	E2F1_20622854_ChIP-Seq_HELA_Human	0.92622907

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005623_abnormal_meninges_morphology	8.92854356
2	MP0000750_abnormal_muscle_regeneration	3.99079276
3	MP0000013_abnormal_adipose_tissue	3.76642387
4	MP0009384_cardiac_valve_regurgitation	3.38360414
5	MP0002938_white_spotting	3.12675619
6	MP0002638_abnormal_pupillary_reflex	3.11497644
7	MP0003786_premature_aging	2.80015668
8	MP0005551_abnormal_eye_electrophysiolog	2.65131900
9	MP0002102_abnormal_ear_morphology	2.59665708
10	MP0003385_abnormal_body_wall	1.76773994
11	MP0008058_abnormal_DNA_repair	1.73645013
12	MP0008877_abnormal_DNA_methylation	1.73117305
13	MP0004147_increased_porphyrin_level	1.70332943
14	MP0002067_abnormal_sensory_capabilities	1.64557066
15	MP0002277_abnormal_respiratory_mucosa	1.62238965
16	MP0000762_abnormal_tongue_morphology	1.58483192
17	MP0003880_abnormal_central_pattern	1.50523876
18	MP0009046_muscle_twitch	1.48320545
19	MP0006292_abnormal_olfactory_placode	1.44863244
20	MP0010307_abnormal_tumor_latency	1.42512737
21	MP0003137_abnormal_impulse_conducting	1.40896533
22	MP0001968_abnormal_touch/_nociception	1.40607557
23	MP0003787_abnormal_imprinting	1.37299091
24	MP0003195_calcinosis	1.35616034
25	MP0004130_abnormal_muscle_cell	1.32421616
26	MP0003011_delayed_dark_adaptation	1.32005481
27	MP0001986_abnormal_taste_sensitivity	1.30551551
28	MP0000003_abnormal_adipose_tissue	1.28788348
29	MP0000631_abnormal_neuroendocrine_gland	1.26053025
30	MP0009745_abnormal_behavioral_response	1.23109179
31	MP0002736_abnormal_nociception_after	1.22830937
32	MP0005645_abnormal_hypothalamus_physiol	1.22687978
33	MP0002272_abnormal_nervous_system	1.21908005
34	MP0002572_abnormal_emotion/affect_behav	1.20751729
35	MP0002837_dystrophic_cardiac_calcinosis	1.20558013
36	MP0002735_abnormal_chemical_nociception	1.18326770
37	MP0001486_abnormal_startle_reflex	1.16426235
38	MP0004142_abnormal_muscle_tone	1.14127251
39	MP0001502_abnormal_circadian_rhythm	1.12992864
40	MP0002160_abnormal_reproductive_system	1.12420485
41	MP0003136_yellow_coat_color	1.12284977
42	MP0002653_abnormal_ependyma_morphology	1.11785173
43	MP0002269_muscular_atrophy	1.11263115
44	MP0002177_abnormal_outer_ear	1.10569569
45	MP0004133_heterotaxia	1.10044693
46	MP0003115_abnormal_respiratory_system	1.08718189
47	MP0003698_abnormal_male_reproductive	1.07646916
48	MP0000858_altered_metastatic_potential	1.04823501
49	MP0005671_abnormal_response_to	1.04017255
50	MP0008775_abnormal_heart_ventricle	1.02438471
51	MP0006276_abnormal_autonomic_nervous	1.02398509
52	MP0002163_abnormal_gland_morphology	1.01515797
53	MP0001485_abnormal_pinna_reflex	0.99453233
54	MP0008872_abnormal_physiological_respon	0.99294415
55	MP0001984_abnormal_olfaction	0.98439368
56	MP0003646_muscle_fatigue	0.97574322
57	MP0008770_decreased_survivor_rate	0.97227587
58	MP0005646_abnormal_pituitary_gland	0.94194509
59	MP0003121_genomic_imprinting	0.94118116
60	MP0005195_abnormal_posterior_eye	0.94030756
61	MP0002064_seizures	0.93527721
62	MP0005584_abnormal_enzyme/coenzyme_acti	0.92717046
63	MP0008995_early_reproductive_senescence	0.92672638
64	MP0002063_abnormal_learning/memory/cond	0.92138018
65	MP0005379_endocrine/exocrine_gland_phen	0.91303236
66	MP0004924_abnormal_behavior	0.89402715
67	MP0005386_behavior/neurological_phenoty	0.89402715
68	MP0003890_abnormal_embryonic-extraembry	0.89354590
69	MP0004043_abnormal_pH_regulation	0.88548945
70	MP0006072_abnormal_retinal_apoptosis	0.87729688
71	MP0003755_abnormal_palate_morphology	0.87544383
72	MP0009379_abnormal_foot_pigmentation	0.86577981
73	MP0004215_abnormal_myocardial_fiber	0.85485974
74	MP0005377_hearing/vestibular/ear_phenot	0.84932585
75	MP0003878_abnormal_ear_physiology	0.84932585
76	MP0005389_reproductive_system_phenotype	0.83092434
77	MP0005410_abnormal_fertilization	0.83022019
78	MP0002752_abnormal_somatic_nervous	0.80019191
79	MP0003635_abnormal_synaptic_transmissio	0.79729039
80	MP0002876_abnormal_thyroid_physiology	0.79493705
81	MP0005253_abnormal_eye_physiology	0.78304911
82	MP0004742_abnormal_vestibular_system	0.78277689
83	MP0002882_abnormal_neuron_morphology	0.77217701
84	MP0003119_abnormal_digestive_system	0.76585820
85	MP0002751_abnormal_autonomic_nervous	0.76055341
86	MP0002210_abnormal_sex_determination	0.76002912
87	MP0004947_skin_inflammation	0.75844607
88	MP0001929_abnormal_gametogenesis	0.75809560
89	MP0004885_abnormal_endolymph	0.75422382
90	MP0002106_abnormal_muscle_physiology	0.75072761
91	MP0008789_abnormal_olfactory_epithelium	0.74745614
92	MP0005083_abnormal_biliary_tract	0.73756431
93	MP0000566_synostosis	0.73236803
94	MP0000427_abnormal_hair_cycle	0.71917035
95	MP0001145_abnormal_male_reproductive	0.71676031
96	MP0002557_abnormal_social/conspecific_i	0.70802526
97	MP0002734_abnormal_mechanical_nocicepti	0.70403102
98	MP0000653_abnormal_sex_gland	0.70302592
99	MP0002234_abnormal_pharynx_morphology	0.70039188
100	MP0005423_abnormal_somatic_nervous	0.69046081

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	9.79554121
2	Retinal dysplasia (HP:0007973)	8.55596212
3	Hypoplasia of the pons (HP:0012110)	8.37222117
4	Abnormality of the pons (HP:0007361)	7.67001720
5	Decreased electroretinogram (ERG) amplitude (HP:0000654)	6.60817543
6	Fatigue (HP:0012378)	6.53863820
7	Buphthalmos (HP:0000557)	6.08245283
8	Aplasia/Hypoplasia affecting the retina (HP:0008061)	5.67961008
9	Abolished electroretinogram (ERG) (HP:0000550)	5.53949475
10	Difficulty climbing stairs (HP:0003551)	5.52044850
11	Severe muscular hypotonia (HP:0006829)	4.20912258
12	Lissencephaly (HP:0001339)	3.87013408
13	Megalocornea (HP:0000485)	3.82540241
14	Congenital glaucoma (HP:0001087)	3.36590814
15	Generalized hypotonia (HP:0001290)	3.31234087
16	Entropion (HP:0000621)	3.18138494
17	Abnormality of DNA repair (HP:0003254)	3.17490549
18	Abnormality of midbrain morphology (HP:0002418)	3.09954408
19	Molar tooth sign on MRI (HP:0002419)	3.09954408
20	Pachygyria (HP:0001302)	3.09801880
21	Nephronophthisis (HP:0000090)	3.01052124
22	Intellectual disability, profound (HP:0002187)	2.98241818
23	Hypoplasia of the brainstem (HP:0002365)	2.98165617
24	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.98165617
25	Abnormality of the vitreous humor (HP:0004327)	2.86695663
26	Meningocele (HP:0002435)	2.86694386
27	Non-midline cleft lip (HP:0100335)	2.81092197
28	Severe global developmental delay (HP:0011344)	2.76885624
29	Poikiloderma (HP:0001029)	2.71182258
30	Pancreatic cysts (HP:0001737)	2.58864269
31	IgG deficiency (HP:0004315)	2.57082182
32	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.52650234
33	Medial flaring of the eyebrow (HP:0010747)	2.51186880
34	Chronic hepatic failure (HP:0100626)	2.49038210
35	Abnormality of the renal medulla (HP:0100957)	2.45809658
36	Mesangial abnormality (HP:0001966)	2.42397959
37	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.40136429
38	Abnormality of vision evoked potentials (HP:0000649)	2.39432142
39	Gowers sign (HP:0003391)	2.38965912
40	True hermaphroditism (HP:0010459)	2.37623364
41	Generalized muscle weakness (HP:0003324)	2.32752460
42	Pancreatic fibrosis (HP:0100732)	2.31181845
43	Polymicrogyria (HP:0002126)	2.29708283
44	Muscular dystrophy (HP:0003560)	2.11821299
45	Cerebellar dysplasia (HP:0007033)	10.8899073
46	Retinal atrophy (HP:0001105)	10.0954979
47	Abnormality of the metopic suture (HP:0005556)	1.96968164
48	Prominent metopic ridge (HP:0005487)	1.95926975
49	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.95394115
50	Tubular atrophy (HP:0000092)	1.94485128
51	Abnormal drinking behavior (HP:0030082)	1.94174306
52	Polydipsia (HP:0001959)	1.94174306
53	Fragile nails (HP:0001808)	1.91724435
54	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.91469552
55	Absent/shortened dynein arms (HP:0200106)	1.91469552
56	Decreased subcutaneous fat (HP:0001002)	1.88790549
57	Holoprosencephaly (HP:0001360)	1.88519013
58	Hypoalbuminemia (HP:0003073)	1.87876398
59	Abnormal albumin level (HP:0012116)	1.87876398
60	Submucous cleft hard palate (HP:0000176)	1.86922048
61	Cystic liver disease (HP:0006706)	1.81691053
62	Brittle hair (HP:0002299)	1.81673406
63	Abnormality of the renal cortex (HP:0011035)	1.81115911
64	Dandy-Walker malformation (HP:0001305)	1.81042201
65	Increased IgM level (HP:0003496)	1.79132643
66	Colon cancer (HP:0003003)	1.77149647
67	Cone-rod dystrophy (HP:0000548)	1.75987601
68	Rectal prolapse (HP:0002035)	1.74074117
69	Abnormal respiratory epithelium morphology (HP:0012253)	1.71624977
70	Abnormal respiratory motile cilium morphology (HP:0005938)	1.71624977
71	Erythroderma (HP:0001019)	1.70329341
72	Congenital hepatic fibrosis (HP:0002612)	1.67625730
73	Papilledema (HP:0001085)	1.66928558
74	Sclerocornea (HP:0000647)	1.65919085
75	Pallor (HP:0000980)	1.64658173
76	Conical tooth (HP:0000698)	1.58561626
77	Intellectual disability, severe (HP:0010864)	1.58178261
78	Occipital encephalocele (HP:0002085)	1.58099086
79	Supranuclear gaze palsy (HP:0000605)	1.56712825
80	Keratitis (HP:0000491)	1.56218753
81	Abnormality of abdominal situs (HP:0011620)	1.54686653
82	Abdominal situs inversus (HP:0003363)	1.54686653
83	Eosinophilia (HP:0001880)	1.54468454
84	Nephropathy (HP:0000112)	1.53922321
85	Cerebral hypomyelination (HP:0006808)	1.51318239
86	Congenital stationary night blindness (HP:0007642)	1.51003099
87	Iris coloboma (HP:0000612)	1.50578385
88	Postaxial foot polydactyly (HP:0001830)	1.49045690
89	Polyuria (HP:0000103)	1.47071774
90	Ectropion (HP:0000656)	1.45306518
91	Sacral dimple (HP:0000960)	1.44995615
92	Atonic seizures (HP:0010819)	1.39201208
93	Optic nerve coloboma (HP:0000588)	1.37170475
94	Everted lower lip vermilion (HP:0000232)	1.36377355
95	Scrotal hypoplasia (HP:0000046)	1.34861886
96	Macular degeneration (HP:0000608)	1.34105797
97	Abnormal ciliary motility (HP:0012262)	1.33087903
98	Abnormality of subcutaneous fat tissue (HP:0001001)	1.32668035
99	Abnormality of eosinophils (HP:0001879)	1.31982965
100	Omphalocele (HP:0001539)	1.31940096

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK3	7.72417929
2	STK10	7.14385916
3	FRK	3.44186539
4	STK11	2.96716853
5	PTK2B	2.84771258
6	PIM1	2.64481018
7	TXK	2.54654894
8	NLK	2.35287644
9	LMTK2	1.95464046
10	MAP4K2	1.90666025
11	WNK3	1.77064961
12	INSRR	1.68882840
13	BMPR1B	1.54529756
14	MAP3K4	1.49801738
15	CAMKK2	1.47162364
16	EPHA3	1.46407533
17	ADRBK2	1.41987233
18	GRK1	1.31409997
19	CASK	1.26586268
20	CDK19	1.22180516
21	PRKCH	1.21754672
22	BRSK2	1.19396307
23	ZAK	1.13876085
24	TLK1	1.13710657
25	ACVR1B	1.13370744
26	MAPK13	1.07841358
27	MAPK15	1.00450635
28	MARK1	0.99825145
29	PINK1	0.93137401
30	CSNK1G1	0.92180584
31	MAP4K1	0.89536333
32	NUAK1	0.89197777
33	WNK4	0.88316071
34	CSNK1G3	0.87316244
35	MAP2K7	0.83951840
36	PIK3CA	0.83731252
37	DYRK2	0.81592992
38	EPHA4	0.79438840
39	CSNK1G2	0.79349358
40	CSNK1A1L	0.75886553
41	DYRK1A	0.73593034
42	DAPK2	0.70152652
43	PRKCE	0.68918957
44	OBSCN	0.68396966
45	PKN1	0.66577188
46	MAP2K2	0.66326271
47	OXSR1	0.64864375
48	PAK3	0.64846057
49	FGFR2	0.63715933
50	MAP3K7	0.63623118
51	PNCK	0.62817158
52	PRKCG	0.61527726
53	CSNK1D	0.57556160
54	TIE1	0.51824024
55	CAMK1	0.51523372
56	NTRK2	0.50959515
57	RPS6KA5	0.49236666
58	TAOK3	0.47807783
59	MUSK	0.46179203
60	BCKDK	0.45305314
61	CLK1	0.45274003
62	GSK3A	0.44924452
63	ADRBK1	0.44801877
64	SRPK1	0.43412241
65	MAP2K6	0.43366326
66	PHKG2	0.43209579
67	PHKG1	0.43209579
68	NEK2	0.42200567
69	TNIK	0.41087648
70	PLK4	0.41000560
71	IRAK1	0.40965802
72	IKBKB	0.40777683
73	TGFBR1	0.40733901
74	CSNK1A1	0.37024388
75	CAMK1D	0.36764626
76	CAMKK1	0.36711365
77	AKT3	0.36483779
78	YES1	0.35274477
79	CAMK1G	0.33310807
80	CAMK2A	0.32597435
81	WNK1	0.32306877
82	NTRK3	0.31736389
83	PRKCQ	0.31413013
84	TNK2	0.30287716
85	UHMK1	0.29351747
86	PRKD2	0.28759051
87	STK39	0.28717519
88	CHUK	0.28277443
89	PRKACA	0.27879665
90	KIT	0.27396333
91	VRK1	0.26969211
92	PRKAA1	0.26891791
93	MELK	0.26627083
94	LCK	0.26085217
95	ERBB2	0.25749122
96	MKNK2	0.25719422
97	PRKCI	0.23504016
98	MAPK14	0.23264415
99	KDR	0.23052766
100	CSNK1E	0.23009559

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	4.81980446
2	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	3.85089914
3	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	2.50908474
4	Phototransduction_Homo sapiens_hsa04744	2.34874592
5	Sulfur relay system_Homo sapiens_hsa04122	2.29244640
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.27831925
7	Regulation of autophagy_Homo sapiens_hsa04140	2.21221228
8	RNA polymerase_Homo sapiens_hsa03020	2.06200452
9	Nicotine addiction_Homo sapiens_hsa05033	2.02002445
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.00130840
11	Oxidative phosphorylation_Homo sapiens_hsa00190	1.94436896
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.89362915
13	Basal transcription factors_Homo sapiens_hsa03022	1.86059195
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.79292345
15	Homologous recombination_Homo sapiens_hsa03440	1.66915603
16	Butanoate metabolism_Homo sapiens_hsa00650	1.62877006
17	Insulin secretion_Homo sapiens_hsa04911	1.59556712
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.59173154
19	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.55234192
20	Huntingtons disease_Homo sapiens_hsa05016	1.48181530
21	Ribosome_Homo sapiens_hsa03010	1.47570746
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.45728685
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.45568247
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.45196662
25	Caffeine metabolism_Homo sapiens_hsa00232	1.42271570
26	Parkinsons disease_Homo sapiens_hsa05012	1.39461072
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.35995553
28	Taste transduction_Homo sapiens_hsa04742	1.35266090
29	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.31985604
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.23754094
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.21693192
32	Cocaine addiction_Homo sapiens_hsa05030	1.20035792
33	Olfactory transduction_Homo sapiens_hsa04740	1.11591379
34	Primary immunodeficiency_Homo sapiens_hsa05340	1.10292147
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.08547856
36	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.04839894
37	ABC transporters_Homo sapiens_hsa02010	1.01887926
38	Peroxisome_Homo sapiens_hsa04146	0.99216676
39	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.96488922
40	Dopaminergic synapse_Homo sapiens_hsa04728	0.94992751
41	Amphetamine addiction_Homo sapiens_hsa05031	0.87487511
42	Graft-versus-host disease_Homo sapiens_hsa05332	0.87363859
43	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.87320740
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.86338178
45	TNF signaling pathway_Homo sapiens_hsa04668	0.85836358
46	Circadian rhythm_Homo sapiens_hsa04710	0.84328986
47	Alzheimers disease_Homo sapiens_hsa05010	0.82626473
48	Nucleotide excision repair_Homo sapiens_hsa03420	0.79022892
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.78186796
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.77238704
51	Morphine addiction_Homo sapiens_hsa05032	0.76723018
52	GABAergic synapse_Homo sapiens_hsa04727	0.76106149
53	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.74900539
54	RNA degradation_Homo sapiens_hsa03018	0.73738896
55	Circadian entrainment_Homo sapiens_hsa04713	0.73176790
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.73135733
57	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.72795439
58	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.72123611
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.71209878
60	Selenocompound metabolism_Homo sapiens_hsa00450	0.70861543
61	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.70761687
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69303031
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.68383667
64	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.68332675
65	Fatty acid degradation_Homo sapiens_hsa00071	0.67741509
66	cAMP signaling pathway_Homo sapiens_hsa04024	0.67421062
67	Glutamatergic synapse_Homo sapiens_hsa04724	0.66927058
68	Serotonergic synapse_Homo sapiens_hsa04726	0.64942192
69	Retinol metabolism_Homo sapiens_hsa00830	0.64699764
70	Propanoate metabolism_Homo sapiens_hsa00640	0.64294157
71	Salivary secretion_Homo sapiens_hsa04970	0.62385103
72	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.61834582
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.60518186
74	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.60473457
75	Toxoplasmosis_Homo sapiens_hsa05145	0.59337999
76	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58038170
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.57634907
78	Purine metabolism_Homo sapiens_hsa00230	0.56686404
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56435918
80	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.56302262
81	Calcium signaling pathway_Homo sapiens_hsa04020	0.54390513
82	Mineral absorption_Homo sapiens_hsa04978	0.52683638
83	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.51783575
84	Histidine metabolism_Homo sapiens_hsa00340	0.50870211
85	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.49923190
86	Leishmaniasis_Homo sapiens_hsa05140	0.48956445
87	Cholinergic synapse_Homo sapiens_hsa04725	0.48009950
88	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.47661939
89	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.47231192
90	Pyrimidine metabolism_Homo sapiens_hsa00240	0.43325012
91	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.43285650
92	Type I diabetes mellitus_Homo sapiens_hsa04940	0.42885791
93	Glucagon signaling pathway_Homo sapiens_hsa04922	0.42295978
94	Gastric acid secretion_Homo sapiens_hsa04971	0.42231496
95	Sulfur metabolism_Homo sapiens_hsa00920	0.41782026
96	MAPK signaling pathway_Homo sapiens_hsa04010	0.41159176
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.40827538
98	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.39468120
99	AMPK signaling pathway_Homo sapiens_hsa04152	0.39025580
100	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.38239441

HKR1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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