HLA-A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.40330716
2* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.15865820
3* antigen processing and presentation of endogenous antigen (GO:0019883)6.09818670
4* antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.88487985
5* negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.82718635
6* negative regulation of cell killing (GO:0031342)5.82718635
7positive regulation of gamma-delta T cell activation (GO:0046645)5.53768245
8positive regulation by symbiont of host defense response (GO:0052509)4.66760945
9modulation by symbiont of host defense response (GO:0052031)4.66760945
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.66760945
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.66760945
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.66760945
13modulation by symbiont of host immune response (GO:0052553)4.66760945
14regulation of B cell receptor signaling pathway (GO:0050855)4.42938530
15* detection of other organism (GO:0098543)4.14108248
16macrophage activation involved in immune response (GO:0002281)4.12920284
17leukocyte aggregation (GO:0070486)4.12740055
18immunoglobulin mediated immune response (GO:0016064)4.12072923
19* cellular response to type I interferon (GO:0071357)4.12064070
20* type I interferon signaling pathway (GO:0060337)4.12064070
21neutrophil activation involved in immune response (GO:0002283)4.11726102
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.10946592
23regulation of gamma-delta T cell activation (GO:0046643)4.10395918
24* response to type I interferon (GO:0034340)4.09734826
25* detection of bacterium (GO:0016045)4.09515725
26response to interleukin-15 (GO:0070672)3.92111800
27negative regulation of interleukin-12 production (GO:0032695)3.87920941
28regulation of T cell tolerance induction (GO:0002664)3.85214422
29response to peptidoglycan (GO:0032494)3.75509068
30negative thymic T cell selection (GO:0045060)3.73740618
31regulation of gamma-delta T cell differentiation (GO:0045586)3.72529956
32negative T cell selection (GO:0043383)3.65924025
33cellular response to interleukin-15 (GO:0071350)3.64738609
34* negative regulation of lymphocyte mediated immunity (GO:0002707)3.62132124
35* interferon-gamma-mediated signaling pathway (GO:0060333)3.60240699
36positive thymic T cell selection (GO:0045059)3.59088253
37regulation of interferon-beta biosynthetic process (GO:0045357)3.57649573
38antigen processing and presentation via MHC class Ib (GO:0002475)3.52266113
39regulation of tolerance induction (GO:0002643)3.51657103
40positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.49622810
41NIK/NF-kappaB signaling (GO:0038061)3.47062098
42* detection of external biotic stimulus (GO:0098581)3.41247278
43regulation of dendritic cell antigen processing and presentation (GO:0002604)3.40143789
44negative regulation of T cell mediated immunity (GO:0002710)3.38709635
45* negative regulation of leukocyte mediated immunity (GO:0002704)3.38480335
46cellular extravasation (GO:0045123)3.35054468
47tolerance induction (GO:0002507)3.34827130
48respiratory burst (GO:0045730)3.33682498
49B cell receptor signaling pathway (GO:0050853)3.32398267
50germinal center formation (GO:0002467)3.31092902
51T cell migration (GO:0072678)3.30292307
52B cell mediated immunity (GO:0019724)3.20410978
53thymic T cell selection (GO:0045061)3.19571945
54neutrophil activation (GO:0042119)3.18727504
55regulation of alpha-beta T cell proliferation (GO:0046640)3.18431177
56response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.17613943
57response to host immune response (GO:0052572)3.17613943
58negative regulation of erythrocyte differentiation (GO:0045647)3.15330712
59* regulation of T cell mediated cytotoxicity (GO:0001914)3.14524780
60T cell selection (GO:0045058)3.13990361
61defense response to protozoan (GO:0042832)3.12693334
62regulation of antigen processing and presentation (GO:0002577)3.12142738
63response to muramyl dipeptide (GO:0032495)3.10124626
64detection of molecule of bacterial origin (GO:0032490)3.08745299
65myeloid cell activation involved in immune response (GO:0002275)3.08643309
66* positive regulation of T cell mediated cytotoxicity (GO:0001916)3.04782689
67positive regulation of B cell differentiation (GO:0045579)3.04682778
68positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.04375336
69regulation of B cell differentiation (GO:0045577)3.03841144
70positive regulation of antigen processing and presentation (GO:0002579)3.02642724
71granulocyte activation (GO:0036230)3.02561880
72positive T cell selection (GO:0043368)3.02424346
73myeloid dendritic cell differentiation (GO:0043011)3.02260890
74regulation of regulatory T cell differentiation (GO:0045589)3.00974569
75response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.00966599
76response to host (GO:0075136)3.00966599
77response to host defenses (GO:0052200)3.00966599
78regulation of mast cell degranulation (GO:0043304)2.96710697
79positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.94731604
80* detection of biotic stimulus (GO:0009595)2.93243903
81negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.92840000
82* regulation of natural killer cell mediated immunity (GO:0002715)2.92787488
83* regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.92787488
84positive regulation of tolerance induction (GO:0002645)2.91366476
85negative regulation of cytokine production involved in immune response (GO:0002719)2.90273898
86myeloid dendritic cell activation (GO:0001773)2.88478694
87response to protozoan (GO:0001562)2.88062502
88regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.86822623
89microglial cell activation (GO:0001774)2.86428972
90lipopolysaccharide-mediated signaling pathway (GO:0031663)2.82938977
91macrophage activation (GO:0042116)2.82132334
92* negative regulation of innate immune response (GO:0045824)2.81152634
93T-helper 1 type immune response (GO:0042088)2.80339507
94negative regulation of phagocytosis (GO:0050765)2.79234211
95regulation of myeloid leukocyte mediated immunity (GO:0002886)2.78677774
96regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.76450598
97regulation of leukocyte degranulation (GO:0043300)2.74265062
98negative regulation of type 2 immune response (GO:0002829)2.72999856
99positive regulation of interferon-alpha production (GO:0032727)2.72786103
100* regulation of leukocyte mediated cytotoxicity (GO:0001910)2.71942155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.60559608
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.16301511
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.66221100
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.61560740
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.43093636
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.40030687
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.15589489
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.86080168
9VDR_21846776_ChIP-Seq_THP-1_Human2.77663474
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.72040198
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.69122203
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.59776086
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.50430148
14MYC_22102868_ChIP-Seq_BL_Human2.44042217
15VDR_24763502_ChIP-Seq_THP-1_Human2.43887264
16MAF_26560356_Chip-Seq_TH1_Human2.43867266
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.42150236
18RUNX_20019798_ChIP-Seq_JUKART_Human2.39721478
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.39512836
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.37577999
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.31356103
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.29445882
23MYB_26560356_Chip-Seq_TH2_Human2.23477128
24* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.21193413
25SPI1_23547873_ChIP-Seq_NB4_Human2.21049871
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.20412648
27UTX_26944678_Chip-Seq_JUKART_Human2.10640329
28SPI1_23127762_ChIP-Seq_K562_Human2.08201625
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.07060912
30KDM2B_26808549_Chip-Seq_SUP-B15_Human2.02648404
31BRD4_27068464_Chip-Seq_AML-cells_Mouse2.01256975
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.01160633
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00531936
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97627122
35MYB_26560356_Chip-Seq_TH1_Human1.96292907
36TCF7_22412390_ChIP-Seq_EML_Mouse1.94828894
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.88589387
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.84724695
39MAF_26560356_Chip-Seq_TH2_Human1.83512014
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78054647
41LXR_22292898_ChIP-Seq_THP-1_Human1.76297968
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.75096180
43SCL_19346495_ChIP-Seq_HPC-7_Human1.71924532
44KDM2B_26808549_Chip-Seq_DND41_Human1.71337645
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69177583
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52639318
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52103269
48GATA3_27048872_Chip-Seq_THYMUS_Human1.49984322
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46192051
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40337634
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40002961
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38554134
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.37823872
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37643725
55VDR_24787735_ChIP-Seq_THP-1_Human1.37205766
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36802783
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33804372
58PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32735340
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32211322
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27284820
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.26358883
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25049404
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24091496
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23614786
65BCL6_27268052_Chip-Seq_Bcells_Human1.19953137
66BCOR_27268052_Chip-Seq_Bcells_Human1.18296021
67PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16067303
68SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16043999
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15804380
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.14174367
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13555359
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12479074
73GATA1_19941826_ChIP-Seq_K562_Human1.11941241
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11932767
75RACK7_27058665_Chip-Seq_MCF-7_Human1.10859202
76PU_27001747_Chip-Seq_BMDM_Mouse1.10711343
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09388165
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09169882
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08367257
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07373225
81GATA3_26560356_Chip-Seq_TH2_Human1.06971028
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05710857
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04068355
84GATA2_21666600_ChIP-Seq_HMVEC_Human1.01227765
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00803057
86RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99428840
87GATA1_22025678_ChIP-Seq_K562_Human0.98436102
88IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97859764
89NCOR1_26117541_ChIP-Seq_K562_Human0.97723530
90SA1_27219007_Chip-Seq_ERYTHROID_Human0.95821434
91ELF1_20517297_ChIP-Seq_JURKAT_Human0.95377314
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95355337
93PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95056823
94VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93638463
95NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93029034
96STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90150725
97TP63_17297297_ChIP-ChIP_HaCaT_Human0.89870771
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86496744
99RXR_22158963_ChIP-Seq_LIVER_Mouse0.85733701
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85639688

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.03845737
2MP0003724_increased_susceptibility_to3.88778575
3MP0001835_abnormal_antigen_presentation3.83414759
4MP0003303_peritoneal_inflammation3.56432819
5MP0005671_abnormal_response_to3.33380555
6MP0000685_abnormal_immune_system3.08882968
7MP0001790_abnormal_immune_system3.08408831
8MP0005387_immune_system_phenotype3.08408831
9MP0001800_abnormal_humoral_immune2.95184404
10MP0005000_abnormal_immune_tolerance2.92741926
11MP0009785_altered_susceptibility_to2.89407347
12MP0005025_abnormal_response_to2.84935449
13MP0002419_abnormal_innate_immunity2.80560971
14MP0006082_CNS_inflammation2.72734085
15MP0003763_abnormal_thymus_physiology2.70607307
16MP0003300_gastrointestinal_ulcer2.67041197
17MP0002723_abnormal_immune_serum2.58066333
18MP0002452_abnormal_antigen_presenting2.51742223
19MP0002420_abnormal_adaptive_immunity2.46276373
20MP0001819_abnormal_immune_cell2.43978031
21MP0002148_abnormal_hypersensitivity_rea2.43592986
22MP0010155_abnormal_intestine_physiology2.22487703
23MP0009333_abnormal_splenocyte_physiolog2.09223005
24MP0001533_abnormal_skeleton_physiology2.07525685
25MP0003191_abnormal_cellular_cholesterol2.05088738
26MP0002405_respiratory_system_inflammati1.97866708
27MP0004947_skin_inflammation1.94550208
28MP0000716_abnormal_immune_system1.87820116
29MP0002398_abnormal_bone_marrow1.87259459
30MP0005464_abnormal_platelet_physiology1.87063142
31MP0001845_abnormal_inflammatory_respons1.84847212
32MP0005058_abnormal_lysosome_morphology1.80604929
33MP0003172_abnormal_lysosome_physiology1.73402835
34MP0003866_abnormal_defecation1.72421656
35MP0005451_abnormal_body_composition1.62604022
36MP0004510_myositis1.61126602
37MP0008260_abnormal_autophagy1.59641331
38MP0001873_stomach_inflammation1.57226535
39MP0000689_abnormal_spleen_morphology1.53862689
40MP0003183_abnormal_peptide_metabolism1.53062507
41MP0008469_abnormal_protein_level1.52124684
42MP0002722_abnormal_immune_system1.51709389
43MP0000465_gastrointestinal_hemorrhage1.50321278
44MP0002429_abnormal_blood_cell1.48647382
45MP0009840_abnormal_foam_cell1.46797278
46MP0005310_abnormal_salivary_gland1.45094090
47MP0000858_altered_metastatic_potential1.44541203
48MP0000703_abnormal_thymus_morphology1.39298849
49MP0002998_abnormal_bone_remodeling1.38819831
50MP0002166_altered_tumor_susceptibility1.37320094
51MP0009278_abnormal_bone_marrow1.34036973
52MP0002138_abnormal_hepatobiliary_system1.30179188
53MP0002132_abnormal_respiratory_system1.30166624
54MP0009764_decreased_sensitivity_to1.30046865
55MP0003075_altered_response_to1.27028869
56MP0002396_abnormal_hematopoietic_system1.24129071
57MP0001851_eye_inflammation1.19508770
58MP0005166_decreased_susceptibility_to1.18559759
59MP0000604_amyloidosis1.14878958
60MP0003828_pulmonary_edema1.13180116
61MP0001853_heart_inflammation1.12733322
62MP0004381_abnormal_hair_follicle1.11305808
63MP0002933_joint_inflammation1.11111770
64MP0000343_altered_response_to1.01472634
65MP0003448_altered_tumor_morphology1.00707012
66MP0000490_abnormal_crypts_of0.99103739
67MP0002277_abnormal_respiratory_mucosa0.98825371
68MP0001663_abnormal_digestive_system0.98381108
69MP0004883_abnormal_blood_vessel0.97866482
70MP0003690_abnormal_glial_cell0.94315751
71MP0005397_hematopoietic_system_phenotyp0.93019202
72MP0001545_abnormal_hematopoietic_system0.93019202
73MP0005164_abnormal_response_to0.92044714
74MP0002006_tumorigenesis0.91727865
75MP0005390_skeleton_phenotype0.88725073
76MP0009763_increased_sensitivity_to0.88558378
77MP0003091_abnormal_cell_migration0.84543859
78MP0003045_fibrosis0.84070637
79MP0003806_abnormal_nucleotide_metabolis0.82964935
80MP0002254_reproductive_system_inflammat0.77941807
81MP0003453_abnormal_keratinocyte_physiol0.77603530
82MP0003795_abnormal_bone_structure0.74058060
83MP0000249_abnormal_blood_vessel0.72989461
84MP0002139_abnormal_hepatobiliary_system0.72521437
85MP0008004_abnormal_stomach_pH0.72398596
86MP0005075_abnormal_melanosome_morpholog0.64838134
87MP0003329_amyloid_beta_deposits0.64773231
88MP0004808_abnormal_hematopoietic_stem0.64607977
89MP0008874_decreased_physiological_sensi0.63774118
90MP0005381_digestive/alimentary_phenotyp0.59928149
91MP0000609_abnormal_liver_physiology0.59829818
92MP0009765_abnormal_xenobiotic_induced0.57532743
93MP0002693_abnormal_pancreas_physiology0.52425480
94MP0005319_abnormal_enzyme/_coenzyme0.51344782
95MP0000015_abnormal_ear_pigmentation0.50792093
96MP0005023_abnormal_wound_healing0.50450441
97MP0002136_abnormal_kidney_physiology0.50197944
98MP0005360_urolithiasis0.49364332
99MP0002877_abnormal_melanocyte_morpholog0.48873965
100MP0000920_abnormal_myelination0.48756002

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.20407374
2Myositis (HP:0100614)5.08567500
3Recurrent abscess formation (HP:0002722)4.97757265
4Abnormality of macrophages (HP:0004311)4.96403418
5Recurrent bacterial skin infections (HP:0005406)4.90593679
6Orchitis (HP:0100796)4.75082694
7Elevated erythrocyte sedimentation rate (HP:0003565)4.43059143
8Retrobulbar optic neuritis (HP:0100654)4.40704972
9Optic neuritis (HP:0100653)4.40704972
10Recurrent gram-negative bacterial infections (HP:0005420)4.07098824
11Mediastinal lymphadenopathy (HP:0100721)3.98905136
12Stomatitis (HP:0010280)3.97793216
13Meningitis (HP:0001287)3.89551533
14Gastrointestinal infarctions (HP:0005244)3.87930280
15Recurrent fungal infections (HP:0002841)3.81491519
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.71288302
17Vasculitis (HP:0002633)3.61269827
18Obstructive lung disease (HP:0006536)3.57854650
19Chronic obstructive pulmonary disease (HP:0006510)3.57854650
20Increased IgE level (HP:0003212)3.50102013
21Recurrent skin infections (HP:0001581)3.37830728
22Encephalitis (HP:0002383)3.31135919
23T lymphocytopenia (HP:0005403)3.28609482
24Spontaneous hematomas (HP:0007420)3.27589972
25Pulmonary infiltrates (HP:0002113)3.19511825
26Keratoconjunctivitis sicca (HP:0001097)3.16849971
27Abnormality of T cell number (HP:0011839)3.15795075
28Cellulitis (HP:0100658)3.15127207
29Gingivitis (HP:0000230)3.15037766
30Chronic mucocutaneous candidiasis (HP:0002728)3.14707580
31Recurrent cutaneous fungal infections (HP:0011370)3.14707580
32Recurrent viral infections (HP:0004429)3.07521174
33Urticaria (HP:0001025)3.04591819
34Pustule (HP:0200039)2.92049764
35Keratoconjunctivitis (HP:0001096)2.90808359
36Chest pain (HP:0100749)2.89596434
37Abnormality of glycolipid metabolism (HP:0010969)2.87861473
38Abnormality of liposaccharide metabolism (HP:0010968)2.87861473
39Abnormality of glycosphingolipid metabolism (HP:0004343)2.87861473
40Increased IgM level (HP:0003496)2.86102959
41Inflammation of the large intestine (HP:0002037)2.85808339
42Gastrointestinal stroma tumor (HP:0100723)2.85666284
43Hemoptysis (HP:0002105)2.84961374
44Gastrointestinal inflammation (HP:0004386)2.80588403
45Abnormality of T cells (HP:0002843)2.78024772
46Recurrent bronchitis (HP:0002837)2.74036266
47Panhypogammaglobulinemia (HP:0003139)2.72033267
48Systemic lupus erythematosus (HP:0002725)2.70825457
49Lymphopenia (HP:0001888)2.69989090
50Colitis (HP:0002583)2.68769640
51Agammaglobulinemia (HP:0004432)2.62310942
52Prolonged bleeding time (HP:0003010)2.60316001
53Abnormality of cells of the lymphoid lineage (HP:0012140)2.57839078
54Hypergammaglobulinemia (HP:0010702)2.54343586
55Petechiae (HP:0000967)2.51250539
56Leukocytosis (HP:0001974)2.49697565
57Pulmonary embolism (HP:0002204)2.49177305
58Granulocytopenia (HP:0001913)2.48147212
59Nasal polyposis (HP:0100582)2.46885078
60Purpura (HP:0000979)2.46812274
61Loss of speech (HP:0002371)2.45223305
62Epistaxis (HP:0000421)2.44654980
63Arterial thrombosis (HP:0004420)2.41542626
64Osteomyelitis (HP:0002754)2.41085987
65Dysostosis multiplex (HP:0000943)2.40502870
66Chronic otitis media (HP:0000389)2.40338007
67Abnormality of T cell physiology (HP:0011840)2.39609171
68Increased cerebral lipofuscin (HP:0011813)2.38599350
69Chronic diarrhea (HP:0002028)2.35575310
70Gingival bleeding (HP:0000225)2.34431411
71Abnormality of the nasal mucosa (HP:0000433)2.33684755
72Amyloidosis (HP:0011034)2.32555849
73Anorexia (HP:0002039)2.31663181
74IgM deficiency (HP:0002850)2.31005543
75Abnormality of the pleura (HP:0002103)2.26436891
76Malnutrition (HP:0004395)2.26033415
77Episodic fever (HP:0001954)2.25683833
78Restrictive lung disease (HP:0002091)2.24589247
79Emphysema (HP:0002097)2.23422844
80Hypochromic anemia (HP:0001931)2.23388091
81Recurrent sinusitis (HP:0011108)2.23068075
82Autoimmune hemolytic anemia (HP:0001890)2.22205163
83Gangrene (HP:0100758)2.22057983
84Sepsis (HP:0100806)2.21841615
85Premature loss of primary teeth (HP:0006323)2.15017025
86Glomerulopathy (HP:0100820)2.08555659
87Autoimmune thrombocytopenia (HP:0001973)2.08471577
88Interstitial pulmonary disease (HP:0006530)2.07610870
89Hepatosplenomegaly (HP:0001433)2.07441033
90Skin ulcer (HP:0200042)2.07322051
91Eosinophilia (HP:0001880)2.06881331
92Increased serum ferritin (HP:0003281)2.02363343
93Arthralgia (HP:0002829)2.01992760
94Vacuolated lymphocytes (HP:0001922)2.01315933
95Recurrent pneumonia (HP:0006532)2.01150641
96Joint swelling (HP:0001386)2.00250532
97Peritonitis (HP:0002586)1.99462217
98Papilloma (HP:0012740)1.96096305
99Verrucae (HP:0200043)1.96096305
100Increased neuronal autofluorescent lipopigment (HP:0002074)1.94533735

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.26369273
2RIPK43.96787775
3ERN13.51249683
4TYK23.01204537
5PRPF4B2.92817820
6BLK2.56311901
7IRAK42.53821579
8CSK2.38753495
9MAP2K32.25946670
10MAP3K142.15384129
11ZAP702.09886922
12TXK2.09425343
13FES2.03953748
14EPHB11.98225113
15TBK11.95831033
16JAK31.93955840
17IKBKE1.86852504
18MAP3K131.83788225
19GRK61.83113005
20MAP3K31.77271775
21BTK1.75666247
22TNK21.75658960
23JAK11.70928989
24MAP3K111.60561017
25SYK1.57878324
26TAOK11.53084716
27FGFR41.52083665
28HCK1.48911460
29SMG11.42385083
30TRIB31.41628700
31SIK31.41610328
32FGR1.35955722
33TESK21.29406780
34LYN1.27218477
35LCK1.25494957
36ITK1.22830794
37CSF1R1.22311974
38KIT1.21643130
39MAP3K11.21242266
40TAOK21.20709836
41JAK21.18287066
42IKBKB1.16655723
43TAOK31.04608968
44SIK10.96745160
45STK100.96623695
46MARK30.96339415
47IRAK30.94522042
48FGFR30.94267912
49PTK60.94192791
50SIK20.93694273
51CDC42BPA0.93668873
52MATK0.88977446
53RIPK10.86311767
54PRKD20.83986859
55TGFBR20.83065181
56PDK10.82759058
57HIPK20.81316219
58KSR20.77708314
59MARK20.77492416
60EPHA30.74361986
61PDPK10.72094293
62IRAK10.71546504
63TEC0.70806604
64BMPR20.69834270
65YES10.68851578
66LRRK20.64549898
67PRKCQ0.63439319
68MAPK70.62184973
69FYN0.60933530
70MAPK120.59490609
71MAP3K70.56580941
72NLK0.55763363
73GRK70.54727263
74MAPK110.54501257
75CAMKK10.47951282
76IRAK20.47284571
77MAP2K60.47205370
78PIM10.47034267
79CHUK0.43642517
80KDR0.43183093
81MAP3K100.42983345
82MAPKAPK20.42337431
83MAP3K60.41607928
84TESK10.41402162
85RPS6KL10.39640319
86RPS6KC10.39640319
87DYRK1B0.38789820
88RET0.37262048
89MAP3K50.37150233
90CDK40.37003755
91PRKG20.34931814
92CAMKK20.34383366
93MOS0.34124851
94MAP3K20.33993260
95MAP3K80.32831801
96ICK0.32642887
97BMX0.31610541
98CDK190.29094879
99RPS6KA60.28952273
100PTK2B0.28716495

Predicted pathways (KEGG)

RankGene SetZ-score
1* Allograft rejection_Homo sapiens_hsa053303.10892369
2* Graft-versus-host disease_Homo sapiens_hsa053322.95896375
3* Autoimmune thyroid disease_Homo sapiens_hsa053202.90221754
4Leishmaniasis_Homo sapiens_hsa051402.80924267
5Staphylococcus aureus infection_Homo sapiens_hsa051502.79403695
6Primary immunodeficiency_Homo sapiens_hsa053402.72770835
7Osteoclast differentiation_Homo sapiens_hsa043802.63539728
8* Type I diabetes mellitus_Homo sapiens_hsa049402.27203731
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.25090643
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.19644995
11B cell receptor signaling pathway_Homo sapiens_hsa046622.15731404
12* Antigen processing and presentation_Homo sapiens_hsa046122.12248500
13Asthma_Homo sapiens_hsa053102.06275267
14* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.02159296
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.96427887
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.94500327
17Other glycan degradation_Homo sapiens_hsa005111.91825493
18Tuberculosis_Homo sapiens_hsa051521.90585975
19* Viral myocarditis_Homo sapiens_hsa054161.90315563
20Measles_Homo sapiens_hsa051621.80580148
21Hematopoietic cell lineage_Homo sapiens_hsa046401.70588740
22T cell receptor signaling pathway_Homo sapiens_hsa046601.70171727
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.67299439
24Toxoplasmosis_Homo sapiens_hsa051451.66221866
25Influenza A_Homo sapiens_hsa051641.60571206
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54395298
27Malaria_Homo sapiens_hsa051441.54084588
28Acute myeloid leukemia_Homo sapiens_hsa052211.53829215
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52850337
30* Herpes simplex infection_Homo sapiens_hsa051681.51868819
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45308999
32Chemokine signaling pathway_Homo sapiens_hsa040621.43132426
33TNF signaling pathway_Homo sapiens_hsa046681.37693215
34Rheumatoid arthritis_Homo sapiens_hsa053231.32860953
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29769630
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27522121
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.26145040
38* Phagosome_Homo sapiens_hsa041451.22607595
39Hepatitis C_Homo sapiens_hsa051601.19272494
40Pertussis_Homo sapiens_hsa051331.17020718
41Legionellosis_Homo sapiens_hsa051341.14034777
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.11636901
43African trypanosomiasis_Homo sapiens_hsa051431.09249066
44Hepatitis B_Homo sapiens_hsa051611.09126702
45Lysosome_Homo sapiens_hsa041421.07216965
46Apoptosis_Homo sapiens_hsa042101.00554813
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00416294
48Shigellosis_Homo sapiens_hsa051310.96013050
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94622845
50Salmonella infection_Homo sapiens_hsa051320.93207404
51Non-small cell lung cancer_Homo sapiens_hsa052230.90964801
52Pancreatic cancer_Homo sapiens_hsa052120.90474779
53* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86661581
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.84488313
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83475995
56Chronic myeloid leukemia_Homo sapiens_hsa052200.82280574
57Platelet activation_Homo sapiens_hsa046110.81365996
58VEGF signaling pathway_Homo sapiens_hsa043700.80017434
59* Epstein-Barr virus infection_Homo sapiens_hsa051690.75797850
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73783606
61Prolactin signaling pathway_Homo sapiens_hsa049170.71970599
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71757172
63* Viral carcinogenesis_Homo sapiens_hsa052030.68463974
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.65654398
65* HTLV-I infection_Homo sapiens_hsa051660.63959702
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.62709434
67* Endocytosis_Homo sapiens_hsa041440.62655948
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61461238
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.60383643
70Renal cell carcinoma_Homo sapiens_hsa052110.58279644
71Notch signaling pathway_Homo sapiens_hsa043300.56384113
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49963231
73Amoebiasis_Homo sapiens_hsa051460.49625525
74Systemic lupus erythematosus_Homo sapiens_hsa053220.48834206
75Insulin resistance_Homo sapiens_hsa049310.47196597
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45563407
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.45392675
78FoxO signaling pathway_Homo sapiens_hsa040680.41499764
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40552571
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40514676
81Endometrial cancer_Homo sapiens_hsa052130.39794493
82HIF-1 signaling pathway_Homo sapiens_hsa040660.39590755
83GnRH signaling pathway_Homo sapiens_hsa049120.39059220
84Complement and coagulation cascades_Homo sapiens_hsa046100.37069790
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36083617
86Choline metabolism in cancer_Homo sapiens_hsa052310.35528529
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33862320
88Prion diseases_Homo sapiens_hsa050200.33571964
89Galactose metabolism_Homo sapiens_hsa000520.32410557
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.31533651
91Fructose and mannose metabolism_Homo sapiens_hsa000510.30356093
92Bladder cancer_Homo sapiens_hsa052190.28922365
93Colorectal cancer_Homo sapiens_hsa052100.28603737
94mTOR signaling pathway_Homo sapiens_hsa041500.28392525
95Inositol phosphate metabolism_Homo sapiens_hsa005620.27809263
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27640972
97MAPK signaling pathway_Homo sapiens_hsa040100.27598549
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24287691
99Type II diabetes mellitus_Homo sapiens_hsa049300.22583518
100Renin-angiotensin system_Homo sapiens_hsa046140.22296671

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