HLA-DMA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* immunoglobulin mediated immune response (GO:0016064)6.22006170
2regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.97836585
3antigen processing and presentation of endogenous antigen (GO:0019883)5.15602211
4regulation of antigen processing and presentation (GO:0002577)5.11953012
5interferon-gamma-mediated signaling pathway (GO:0060333)4.93389161
6positive regulation of gamma-delta T cell activation (GO:0046645)4.82786461
7* B cell mediated immunity (GO:0019724)4.80113309
8positive regulation of antigen processing and presentation (GO:0002579)4.68616389
9regulation of dendritic cell antigen processing and presentation (GO:0002604)4.40240413
10neutrophil activation involved in immune response (GO:0002283)4.32778595
11detection of bacterium (GO:0016045)4.32223037
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.28974537
13detection of other organism (GO:0098543)4.22785187
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.20986104
15regulation of B cell receptor signaling pathway (GO:0050855)4.12080774
16response to peptidoglycan (GO:0032494)4.08141790
17T-helper 1 type immune response (GO:0042088)4.00832135
18B cell receptor signaling pathway (GO:0050853)4.00349269
19positive regulation of B cell differentiation (GO:0045579)3.98375665
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.97861281
21negative regulation of interleukin-12 production (GO:0032695)3.93745410
22cellular response to interferon-gamma (GO:0071346)3.88700994
23macrophage activation involved in immune response (GO:0002281)3.81354252
24positive regulation by symbiont of host defense response (GO:0052509)3.78629379
25modulation by symbiont of host defense response (GO:0052031)3.78629379
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.78629379
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.78629379
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.78629379
29modulation by symbiont of host immune response (GO:0052553)3.78629379
30negative regulation of cell killing (GO:0031342)3.69409037
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.69409037
32type I interferon signaling pathway (GO:0060337)3.58151996
33cellular response to type I interferon (GO:0071357)3.58151996
34defense response to protozoan (GO:0042832)3.56895736
35response to type I interferon (GO:0034340)3.55968953
36response to interferon-gamma (GO:0034341)3.50987319
37positive regulation of type 2 immune response (GO:0002830)3.50818260
38T cell costimulation (GO:0031295)3.50644874
39lymphocyte costimulation (GO:0031294)3.45337995
40regulation of interferon-beta biosynthetic process (GO:0045357)3.41463591
41regulation of gamma-delta T cell activation (GO:0046643)3.39366112
42negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.39034238
43detection of external biotic stimulus (GO:0098581)3.37751236
44response to protozoan (GO:0001562)3.33593211
45positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.32813849
46regulation of mast cell degranulation (GO:0043304)3.28096707
47regulation of T-helper 1 cell differentiation (GO:0045625)3.25855577
48regulation of B cell differentiation (GO:0045577)3.23219878
49myeloid cell activation involved in immune response (GO:0002275)3.21641626
50regulation of mast cell activation (GO:0033003)3.19382038
51* positive thymic T cell selection (GO:0045059)3.19082824
52positive regulation of mast cell activation (GO:0033005)3.18708107
53regulation of interferon-alpha production (GO:0032647)3.17864140
54positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.17050150
55NIK/NF-kappaB signaling (GO:0038061)3.10985921
56negative thymic T cell selection (GO:0045060)3.09770880
57positive regulation of mast cell degranulation (GO:0043306)3.09338541
58positive regulation of mast cell activation involved in immune response (GO:0033008)3.09338541
59positive regulation of interferon-alpha production (GO:0032727)3.08215107
60response to interferon-beta (GO:0035456)3.03629493
61germinal center formation (GO:0002467)3.02907441
62myeloid dendritic cell activation (GO:0001773)3.01927216
63detection of biotic stimulus (GO:0009595)3.00105704
64production of molecular mediator of immune response (GO:0002440)2.99909537
65regulation of mast cell activation involved in immune response (GO:0033006)2.99573111
66microglial cell activation (GO:0001774)2.98919898
67mature B cell differentiation involved in immune response (GO:0002313)2.96801127
68antigen receptor-mediated signaling pathway (GO:0050851)2.94627756
69response to muramyl dipeptide (GO:0032495)2.94535861
70regulation of B cell apoptotic process (GO:0002902)2.90528786
71response to host immune response (GO:0052572)2.90323271
72response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.90323271
73regulation of gamma-delta T cell differentiation (GO:0045586)2.87244259
74positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.86181981
75negative T cell selection (GO:0043383)2.84877328
76regulation of alpha-beta T cell proliferation (GO:0046640)2.84683988
77regulation of germinal center formation (GO:0002634)2.84326269
78Arp2/3 complex-mediated actin nucleation (GO:0034314)2.83388641
79regulation of inflammatory response to antigenic stimulus (GO:0002861)2.82984830
80* adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.80319547
81regulation of myeloid leukocyte mediated immunity (GO:0002886)2.80201005
82T cell migration (GO:0072678)2.77977824
83granulocyte activation (GO:0036230)2.77544451
84neutrophil activation (GO:0042119)2.77092450
85lipopolysaccharide-mediated signaling pathway (GO:0031663)2.75902427
86cellular response to exogenous dsRNA (GO:0071360)2.75592158
87positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.75110842
88positive regulation of macrophage cytokine production (GO:0060907)2.74126948
89myeloid dendritic cell differentiation (GO:0043011)2.73671320
90positive regulation of B cell activation (GO:0050871)2.69591962
91macrophage activation (GO:0042116)2.69527796
92regulation of leukocyte degranulation (GO:0043300)2.69351230
93regulation of T cell tolerance induction (GO:0002664)2.68820383
94negative regulation of innate immune response (GO:0045824)2.68701635
95regulation of tolerance induction (GO:0002643)2.67484387
96regulation of hypersensitivity (GO:0002883)2.66767852
97regulation of interleukin-12 production (GO:0032655)2.65221814
98negative regulation of cytokine production involved in immune response (GO:0002719)2.65058550
99regulation of type 2 immune response (GO:0002828)2.64604048
100mast cell activation (GO:0045576)2.64152619

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.99625850
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.17779843
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.68404529
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.12634950
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.51823350
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.26886983
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.08648953
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.02667922
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.94759573
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.86872634
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.86676113
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51284123
13* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.50945831
14* SPI1_23547873_ChIP-Seq_NB4_Human2.47756276
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.37054989
16VDR_24763502_ChIP-Seq_THP-1_Human2.36508937
17SCL_19346495_ChIP-Seq_HPC-7_Human2.33000122
18VDR_21846776_ChIP-Seq_THP-1_Human2.28906496
19MYB_26560356_Chip-Seq_TH2_Human2.28488181
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.28004778
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.27834938
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.24107147
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.18570627
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.17349248
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.14744998
26RUNX_20019798_ChIP-Seq_JUKART_Human2.01923451
27SPI1_23127762_ChIP-Seq_K562_Human1.98994883
28MYC_22102868_ChIP-Seq_BL_Human1.96391987
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.88343068
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.87987694
31MAF_26560356_Chip-Seq_TH1_Human1.84858904
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.81385436
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79534876
34* MYB_26560356_Chip-Seq_TH1_Human1.77058520
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76629604
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75438760
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.73955575
38VDR_24787735_ChIP-Seq_THP-1_Human1.71569470
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71017652
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68177003
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.67178749
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.63726306
43* CIITA_25753668_ChIP-Seq_RAJI_Human1.63123722
44UTX_26944678_Chip-Seq_JUKART_Human1.61729793
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58803355
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.55852978
47GATA3_27048872_Chip-Seq_THYMUS_Human1.55034930
48GATA3_26560356_Chip-Seq_TH2_Human1.44307966
49GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.42704136
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39813052
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34752235
52BCL6_27268052_Chip-Seq_Bcells_Human1.34142792
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.34038465
54MAF_26560356_Chip-Seq_TH2_Human1.31122643
55GATA1_22025678_ChIP-Seq_K562_Human1.27570282
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25443035
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22959462
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.22603893
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21303520
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20882848
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.18684116
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17228090
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16277335
64BCOR_27268052_Chip-Seq_Bcells_Human1.15932905
65* STAT1_20625510_ChIP-Seq_HELA_Human1.14854603
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14458247
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11693036
68CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11066244
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08852041
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08049144
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07714127
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07569802
73PU_27001747_Chip-Seq_BMDM_Mouse1.07130058
74PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06610986
75TCF7_22412390_ChIP-Seq_EML_Mouse1.05751713
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03571442
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03286237
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03071123
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02240752
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99871331
81LXR_22292898_ChIP-Seq_THP-1_Human0.99344252
82P300_27268052_Chip-Seq_Bcells_Human0.98227792
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96749680
84GATA1_19941826_ChIP-Seq_K562_Human0.94791758
85EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93510577
86GATA2_21666600_ChIP-Seq_HMVEC_Human0.91828852
87SPI1_20517297_ChIP-Seq_HL60_Human0.91592663
88ELK3_25401928_ChIP-Seq_HUVEC_Human0.87150946
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87073081
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85219608
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82706758
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81055320
93PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.79863754
94KDM2B_26808549_Chip-Seq_DND41_Human0.78812260
95CTCF_26484167_Chip-Seq_Bcells_Mouse0.78800366
96STAT6_21828071_ChIP-Seq_BEAS2B_Human0.78373318
97SMRT_27268052_Chip-Seq_Bcells_Human0.76702737
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.76661206
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75909279
100TFEB_21752829_ChIP-Seq_HELA_Human0.75199351

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.68631040
2MP0003303_peritoneal_inflammation3.49110585
3MP0005671_abnormal_response_to3.46183298
4MP0003436_decreased_susceptibility_to3.27354326
5MP0001790_abnormal_immune_system3.26685772
6MP0005387_immune_system_phenotype3.26685772
7MP0003724_increased_susceptibility_to3.22778947
8MP0002148_abnormal_hypersensitivity_rea3.21307522
9MP0001800_abnormal_humoral_immune3.14749506
10MP0000685_abnormal_immune_system3.11338745
11MP0005000_abnormal_immune_tolerance3.04039191
12MP0009785_altered_susceptibility_to2.90328670
13MP0002452_abnormal_antigen_presenting2.77806026
14MP0002419_abnormal_innate_immunity2.75432287
15MP0005025_abnormal_response_to2.71533197
16MP0002723_abnormal_immune_serum2.66916261
17MP0006082_CNS_inflammation2.49920035
18MP0002420_abnormal_adaptive_immunity2.45367232
19MP0005058_abnormal_lysosome_morphology2.44632865
20MP0001819_abnormal_immune_cell2.43055030
21MP0002138_abnormal_hepatobiliary_system2.14211839
22MP0005464_abnormal_platelet_physiology2.13001916
23MP0010155_abnormal_intestine_physiology2.12535453
24MP0003172_abnormal_lysosome_physiology2.00877237
25MP0000716_abnormal_immune_system1.88693239
26MP0001845_abnormal_inflammatory_respons1.87620083
27MP0002405_respiratory_system_inflammati1.82741707
28MP0003191_abnormal_cellular_cholesterol1.82094938
29MP0002398_abnormal_bone_marrow1.81789839
30MP0009840_abnormal_foam_cell1.76735727
31MP0009278_abnormal_bone_marrow1.75467039
32MP0001533_abnormal_skeleton_physiology1.73261329
33MP0009764_decreased_sensitivity_to1.71768955
34MP0003300_gastrointestinal_ulcer1.71192694
35MP0003763_abnormal_thymus_physiology1.70573845
36MP0003183_abnormal_peptide_metabolism1.70257461
37MP0003075_altered_response_to1.69386077
38MP0004947_skin_inflammation1.67292992
39MP0001853_heart_inflammation1.66899603
40MP0001545_abnormal_hematopoietic_system1.65327016
41MP0005397_hematopoietic_system_phenotyp1.65327016
42MP0002139_abnormal_hepatobiliary_system1.65185762
43MP0003806_abnormal_nucleotide_metabolis1.62254237
44MP0002166_altered_tumor_susceptibility1.61956187
45MP0000689_abnormal_spleen_morphology1.59677759
46MP0008469_abnormal_protein_level1.59430172
47MP0009333_abnormal_splenocyte_physiolog1.57637220
48MP0002429_abnormal_blood_cell1.50738563
49MP0002722_abnormal_immune_system1.40147903
50MP0005310_abnormal_salivary_gland1.37387968
51MP0000343_altered_response_to1.35328784
52MP0001873_stomach_inflammation1.30397624
53MP0005166_decreased_susceptibility_to1.27937047
54MP0000465_gastrointestinal_hemorrhage1.24951464
55MP0000604_amyloidosis1.22579059
56MP0003866_abnormal_defecation1.18155227
57MP0005451_abnormal_body_composition1.18135632
58MP0002998_abnormal_bone_remodeling1.16763213
59MP0002006_tumorigenesis1.12532694
60MP0000858_altered_metastatic_potential1.08270758
61MP0001663_abnormal_digestive_system0.99716793
62MP0004808_abnormal_hematopoietic_stem0.92303917
63MP0009763_increased_sensitivity_to0.92197964
64MP0002396_abnormal_hematopoietic_system0.91499300
65MP0003448_altered_tumor_morphology0.91207337
66MP0003828_pulmonary_edema0.91092269
67MP0000703_abnormal_thymus_morphology0.90936152
68MP0008004_abnormal_stomach_pH0.90741822
69MP0002132_abnormal_respiratory_system0.90401987
70MP0004510_myositis0.87666908
71MP0005165_increased_susceptibility_to0.83127917
72MP0000249_abnormal_blood_vessel0.82996609
73MP0002933_joint_inflammation0.81422867
74MP0005167_abnormal_blood-brain_barrier0.80015709
75MP0005075_abnormal_melanosome_morpholog0.78354430
76MP0000490_abnormal_crypts_of0.77258560
77MP0003690_abnormal_glial_cell0.74239888
78MP0004883_abnormal_blood_vessel0.73675982
79MP0005390_skeleton_phenotype0.73442806
80MP0008260_abnormal_autophagy0.73025820
81MP0005360_urolithiasis0.71942575
82MP0001851_eye_inflammation0.70548283
83MP0005164_abnormal_response_to0.69258955
84MP0002136_abnormal_kidney_physiology0.65021762
85MP0003656_abnormal_erythrocyte_physiolo0.64302021
86MP0009765_abnormal_xenobiotic_induced0.64294708
87MP0005365_abnormal_bile_salt0.63489253
88MP0009643_abnormal_urine_homeostasis0.62467074
89MP0002019_abnormal_tumor_incidence0.60043288
90MP0005319_abnormal_enzyme/_coenzyme0.59626441
91MP0003795_abnormal_bone_structure0.58108866
92MP0003045_fibrosis0.57955316
93MP0000015_abnormal_ear_pigmentation0.56457630
94MP0000609_abnormal_liver_physiology0.56001678
95MP0005584_abnormal_enzyme/coenzyme_acti0.55075179
96MP0008875_abnormal_xenobiotic_pharmacok0.54569200
97MP0005381_digestive/alimentary_phenotyp0.53362732
98MP0005535_abnormal_body_temperature0.51049177
99MP0001764_abnormal_homeostasis0.50889572
100MP0008874_decreased_physiological_sensi0.50625076

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)4.82373255
2Abnormality of glycolipid metabolism (HP:0010969)4.67009745
3Abnormality of liposaccharide metabolism (HP:0010968)4.67009745
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.67009745
5Meningitis (HP:0001287)4.33515861
6Recurrent bacterial skin infections (HP:0005406)4.33467219
7Recurrent abscess formation (HP:0002722)4.29816931
8Panhypogammaglobulinemia (HP:0003139)4.17988098
9Mediastinal lymphadenopathy (HP:0100721)4.10993692
10Abnormality of macrophages (HP:0004311)4.10088675
11Systemic lupus erythematosus (HP:0002725)4.05777894
12Eczematoid dermatitis (HP:0000976)4.04261183
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.87537996
14Elevated erythrocyte sedimentation rate (HP:0003565)3.87391611
15Recurrent fungal infections (HP:0002841)3.72338342
16Obstructive lung disease (HP:0006536)3.69526575
17Chronic obstructive pulmonary disease (HP:0006510)3.69526575
18Myositis (HP:0100614)3.64256275
19Vasculitis (HP:0002633)3.62146482
20Increased cerebral lipofuscin (HP:0011813)3.53287123
21Abnormality of the prostate (HP:0008775)3.52544594
22Pulmonary infiltrates (HP:0002113)3.49054448
23Recurrent viral infections (HP:0004429)3.46753496
24Recurrent cutaneous fungal infections (HP:0011370)3.37366290
25Chronic mucocutaneous candidiasis (HP:0002728)3.37366290
26Recurrent gram-negative bacterial infections (HP:0005420)3.25350863
27Orchitis (HP:0100796)3.23101749
28Recurrent skin infections (HP:0001581)3.21620540
29Gastrointestinal stroma tumor (HP:0100723)3.18882191
30Autoimmune thrombocytopenia (HP:0001973)3.18868879
31Colitis (HP:0002583)3.18854719
32Vacuolated lymphocytes (HP:0001922)3.16728174
33Abnormality of B cell number (HP:0010975)3.15259080
34Increased neuronal autofluorescent lipopigment (HP:0002074)3.13661081
35Cellulitis (HP:0100658)3.12182415
36Optic neuritis (HP:0100653)3.11412377
37Retrobulbar optic neuritis (HP:0100654)3.11412377
38Dysostosis multiplex (HP:0000943)3.07027014
39Stomatitis (HP:0010280)3.04529321
40Urticaria (HP:0001025)3.02048743
41Encephalitis (HP:0002383)2.95866237
42Recurrent bronchitis (HP:0002837)2.90360671
43Hemoptysis (HP:0002105)2.87678972
44Recurrent sinusitis (HP:0011108)2.84453245
45Inflammation of the large intestine (HP:0002037)2.84062232
46Chest pain (HP:0100749)2.81015840
47Restrictive lung disease (HP:0002091)2.71213253
48Gastrointestinal inflammation (HP:0004386)2.69323284
49B lymphocytopenia (HP:0010976)2.68179598
50Increased IgM level (HP:0003496)2.60059274
51Abnormality of the pleura (HP:0002103)2.57329131
52Petechiae (HP:0000967)2.56258212
53Loss of speech (HP:0002371)2.55967960
54Osteomyelitis (HP:0002754)2.55559583
55Purpura (HP:0000979)2.51514646
56Abnormality of T cell number (HP:0011839)2.51101066
57Abnormality of T cells (HP:0002843)2.49595384
58Pustule (HP:0200039)2.47019235
59Pulmonary fibrosis (HP:0002206)2.46273855
60Autoimmune hemolytic anemia (HP:0001890)2.46242548
61Chronic diarrhea (HP:0002028)2.43654738
62Abnormality of T cell physiology (HP:0011840)2.43444982
63Granulocytopenia (HP:0001913)2.42719992
64Increased IgE level (HP:0003212)2.42710107
65Recurrent pneumonia (HP:0006532)2.41574679
66Spontaneous hematomas (HP:0007420)2.39469641
67Skin rash (HP:0000988)2.37343688
68T lymphocytopenia (HP:0005403)2.36606106
69Epistaxis (HP:0000421)2.36428698
70Gastrointestinal infarctions (HP:0005244)2.34823808
71Lymphopenia (HP:0001888)2.33792078
72Chronic otitis media (HP:0000389)2.33765340
73Pulmonary embolism (HP:0002204)2.32188544
74Eosinophilia (HP:0001880)2.31948728
75Recurrent lower respiratory tract infections (HP:0002783)2.31699696
76Glomerulonephritis (HP:0000099)2.31579471
77Abnormality of mucopolysaccharide metabolism (HP:0011020)2.31222656
78Abnormality of polysaccharide metabolism (HP:0011012)2.31222656
79Abnormality of glycosaminoglycan metabolism (HP:0004371)2.31222656
80Hypergammaglobulinemia (HP:0010702)2.29958659
81Gangrene (HP:0100758)2.28126609
82IgM deficiency (HP:0002850)2.27146283
83Prostate neoplasm (HP:0100787)2.26955526
84Abnormality of cells of the lymphoid lineage (HP:0012140)2.26066107
85Leukocytosis (HP:0001974)2.25175592
86IgG deficiency (HP:0004315)2.24469664
87Keratoconjunctivitis sicca (HP:0001097)2.23970237
88Verrucae (HP:0200043)2.22847516
89Papilloma (HP:0012740)2.22847516
90Increased serum ferritin (HP:0003281)2.21900726
91Disinhibition (HP:0000734)2.19941327
92Hepatosplenomegaly (HP:0001433)2.15279165
93Mucopolysacchariduria (HP:0008155)2.12643145
94Urinary glycosaminoglycan excretion (HP:0003541)2.12643145
95Arterial thrombosis (HP:0004420)2.12083388
96Gingivitis (HP:0000230)2.11799176
97Prolonged bleeding time (HP:0003010)2.11195658
98Sepsis (HP:0100806)2.11038541
99Hypertensive crisis (HP:0100735)2.08758869
100Keratoconjunctivitis (HP:0001096)2.08323621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.34640402
2RIPK44.14210974
3BLK3.29145282
4ERN13.01805622
5KIT2.75680674
6TYK22.59214590
7CSF1R2.54914029
8TBK12.54269925
9MAP3K142.47973672
10BMPR22.44177170
11SYK2.42151654
12FES2.27016926
13IRAK42.11884766
14TAOK32.11176391
15IKBKB2.04278555
16IKBKE2.01927053
17TXK2.00095405
18BTK1.99423852
19NME21.99232899
20JAK31.94900062
21CSK1.75204477
22LYN1.73815243
23MAP3K131.69887885
24TEC1.68335660
25ZAP701.55428551
26ITK1.52018214
27GRK71.48935519
28TESK21.46841732
29MATK1.45936423
30MAP2K31.43103269
31HCK1.35286179
32PRPF4B1.29894354
33TNK21.28011726
34LCK1.23255009
35MAP3K111.21589489
36IRAK31.20570716
37MAP3K31.15888949
38JAK11.14665953
39TGFBR21.14194991
40TLK11.10612132
41GRK61.07216223
42SIK31.05703355
43FGR1.04577046
44BCKDK1.01462495
45ADRBK20.95199197
46KDR0.94316112
47JAK20.93006557
48PRKCQ0.82032136
49CDC42BPA0.79949621
50CDK190.79499328
51MAP3K100.77195813
52CHUK0.74250202
53TAOK20.73528792
54PDK10.71924328
55HIPK20.70572073
56STK100.68957611
57PIM20.65553629
58IRAK10.65458994
59MAPK70.63959152
60ABL10.61384844
61PIM10.61370166
62MAP3K10.60082303
63TRPM70.59841173
64SMG10.59579847
65DAPK20.59415141
66MARK30.59093111
67TGFBR10.58463556
68PIK3CG0.56114261
69MAPK110.55043214
70EIF2AK30.52953600
71TAOK10.51920965
72MST40.50392780
73MAPK120.50254653
74PDPK10.49203599
75SIK20.48602958
76LRRK20.46403347
77VRK20.46255082
78ACVR1B0.44709834
79MAP2K20.43271942
80MAPKAPK30.43098494
81FYN0.42119941
82RPS6KL10.42020540
83RPS6KC10.42020540
84ABL20.41450521
85BMPR1B0.40642938
86MAP3K50.40253740
87DAPK10.39909075
88PRKCD0.38747102
89RPS6KA60.38595878
90MOS0.38538074
91MAP2K60.37687663
92MAPKAPK20.36710302
93MAPK40.36658251
94IGF1R0.36471447
95IRAK20.34975273
96CDK40.34930604
97CDK60.33675907
98FLT30.32361886
99DAPK30.30496136
100CDK90.30118171

Predicted pathways (KEGG)

RankGene SetZ-score
1* Asthma_Homo sapiens_hsa053105.10335444
2* Allograft rejection_Homo sapiens_hsa053304.78390948
3* Autoimmune thyroid disease_Homo sapiens_hsa053204.43018675
4* Graft-versus-host disease_Homo sapiens_hsa053324.38178815
5* Intestinal immune network for IgA production_Homo sapiens_hsa046724.19280758
6* Staphylococcus aureus infection_Homo sapiens_hsa051503.68463280
7* Type I diabetes mellitus_Homo sapiens_hsa049403.65842204
8* Leishmaniasis_Homo sapiens_hsa051403.05362843
9* Antigen processing and presentation_Homo sapiens_hsa046122.94952516
10* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.82382854
11* Viral myocarditis_Homo sapiens_hsa054162.57042716
12* Rheumatoid arthritis_Homo sapiens_hsa053232.39470800
13Primary immunodeficiency_Homo sapiens_hsa053402.39199686
14Other glycan degradation_Homo sapiens_hsa005112.01195420
15* Tuberculosis_Homo sapiens_hsa051521.89365480
16Hematopoietic cell lineage_Homo sapiens_hsa046401.87786115
17B cell receptor signaling pathway_Homo sapiens_hsa046621.69954793
18Osteoclast differentiation_Homo sapiens_hsa043801.67069728
19* Toxoplasmosis_Homo sapiens_hsa051451.65899221
20* Influenza A_Homo sapiens_hsa051641.51348885
21* Herpes simplex infection_Homo sapiens_hsa051681.49192760
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.46951811
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39931098
24* Phagosome_Homo sapiens_hsa041451.35095334
25Lysosome_Homo sapiens_hsa041421.33006976
26* Systemic lupus erythematosus_Homo sapiens_hsa053221.28341801
27Pertussis_Homo sapiens_hsa051331.16100265
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11074829
29* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10114080
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09878744
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00086999
32Glycosaminoglycan degradation_Homo sapiens_hsa005310.94395654
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93965498
34Legionellosis_Homo sapiens_hsa051340.90192660
35Measles_Homo sapiens_hsa051620.89321451
36Malaria_Homo sapiens_hsa051440.89232588
37TNF signaling pathway_Homo sapiens_hsa046680.80153184
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78048250
39Epstein-Barr virus infection_Homo sapiens_hsa051690.77192633
40SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73924730
41African trypanosomiasis_Homo sapiens_hsa051430.69518794
42Chemokine signaling pathway_Homo sapiens_hsa040620.69494387
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69281220
44Jak-STAT signaling pathway_Homo sapiens_hsa046300.69074015
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68636886
46T cell receptor signaling pathway_Homo sapiens_hsa046600.65785784
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61544019
48Salmonella infection_Homo sapiens_hsa051320.60260305
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55298761
50Hepatitis C_Homo sapiens_hsa051600.52765151
51Platelet activation_Homo sapiens_hsa046110.50688728
52Apoptosis_Homo sapiens_hsa042100.49891714
53* HTLV-I infection_Homo sapiens_hsa051660.49538107
54Acute myeloid leukemia_Homo sapiens_hsa052210.47224859
55Arachidonic acid metabolism_Homo sapiens_hsa005900.44080861
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43697319
57Shigellosis_Homo sapiens_hsa051310.43457189
58Hepatitis B_Homo sapiens_hsa051610.42467353
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39053707
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.33684087
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27844435
62Complement and coagulation cascades_Homo sapiens_hsa046100.27436316
63Renin-angiotensin system_Homo sapiens_hsa046140.27293595
64Collecting duct acid secretion_Homo sapiens_hsa049660.25400902
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24550662
66Ether lipid metabolism_Homo sapiens_hsa005650.22165457
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21816685
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21506644
69Linoleic acid metabolism_Homo sapiens_hsa005910.20833765
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.18150006
71Viral carcinogenesis_Homo sapiens_hsa052030.17367507
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.15808916
73Sphingolipid metabolism_Homo sapiens_hsa006000.15542213
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14841985
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.13380098
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12384222
77Prolactin signaling pathway_Homo sapiens_hsa049170.11629456
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.11234783
79Sulfur metabolism_Homo sapiens_hsa009200.11090156
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.09631465
81Tryptophan metabolism_Homo sapiens_hsa003800.07342006
82Caffeine metabolism_Homo sapiens_hsa002320.06121329
83VEGF signaling pathway_Homo sapiens_hsa043700.05788026
84PPAR signaling pathway_Homo sapiens_hsa033200.05592669
85Endocytosis_Homo sapiens_hsa041440.05436999
86Amoebiasis_Homo sapiens_hsa051460.05372680
87Proteasome_Homo sapiens_hsa030500.05008029
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.04112390
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.03763800
90Peroxisome_Homo sapiens_hsa041460.03761170
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.03253176
92Mineral absorption_Homo sapiens_hsa049780.02298478
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.00328615
94Bladder cancer_Homo sapiens_hsa05219-0.0402425
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0347546
96Galactose metabolism_Homo sapiens_hsa00052-0.0295366
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933-0.0217260
98Non-small cell lung cancer_Homo sapiens_hsa05223-0.0215933
99Insulin resistance_Homo sapiens_hsa04931-0.0197418
100Glycerolipid metabolism_Homo sapiens_hsa00561-0.0162041

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