HLA-DMB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)6.27681627
2positive regulation of gamma-delta T cell activation (GO:0046645)5.44263765
3regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.27311593
4antigen processing and presentation of endogenous antigen (GO:0019883)5.23989227
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.97907253
6B cell mediated immunity (GO:0019724)4.86862124
7interferon-gamma-mediated signaling pathway (GO:0060333)4.81802772
8detection of other organism (GO:0098543)4.70772259
9detection of bacterium (GO:0016045)4.68758993
10neutrophil activation involved in immune response (GO:0002283)4.64887860
11regulation of antigen processing and presentation (GO:0002577)4.63112241
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.60414036
13regulation of B cell receptor signaling pathway (GO:0050855)4.59337406
14negative regulation of cell killing (GO:0031342)4.55721416
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.55721416
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.36451916
17positive regulation by organism of defense response of other organism involved in symbiotic interact4.29976888
18modulation by symbiont of host immune response (GO:0052553)4.29976888
19positive regulation by symbiont of host defense response (GO:0052509)4.29976888
20modulation by symbiont of host defense response (GO:0052031)4.29976888
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.29976888
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.29976888
23response to peptidoglycan (GO:0032494)4.26447473
24positive regulation of antigen processing and presentation (GO:0002579)4.26256744
25macrophage activation involved in immune response (GO:0002281)4.26088313
26regulation of dendritic cell antigen processing and presentation (GO:0002604)4.25103087
27B cell receptor signaling pathway (GO:0050853)4.21047333
28positive thymic T cell selection (GO:0045059)4.18834963
29detection of external biotic stimulus (GO:0098581)3.95959769
30regulation of gamma-delta T cell activation (GO:0046643)3.88180027
31negative regulation of interleukin-12 production (GO:0032695)3.86613685
32T-helper 1 type immune response (GO:0042088)3.82265433
33positive regulation of B cell differentiation (GO:0045579)3.81711610
34positive regulation of mast cell activation (GO:0033005)3.76392784
35cellular response to interferon-gamma (GO:0071346)3.71831427
36positive regulation of mast cell activation involved in immune response (GO:0033008)3.63404887
37positive regulation of mast cell degranulation (GO:0043306)3.63404887
38regulation of mast cell degranulation (GO:0043304)3.59233167
39defense response to protozoan (GO:0042832)3.58117199
40T cell costimulation (GO:0031295)3.57781767
41regulation of interferon-beta biosynthetic process (GO:0045357)3.57531136
42lymphocyte costimulation (GO:0031294)3.52396524
43positive regulation of type 2 immune response (GO:0002830)3.46898658
44detection of biotic stimulus (GO:0009595)3.46504278
45cellular response to type I interferon (GO:0071357)3.40794217
46type I interferon signaling pathway (GO:0060337)3.40794217
47detection of molecule of bacterial origin (GO:0032490)3.39479946
48response to type I interferon (GO:0034340)3.37674265
49regulation of B cell differentiation (GO:0045577)3.35775349
50response to interferon-gamma (GO:0034341)3.34750975
51regulation of mast cell activation (GO:0033003)3.33459304
52myeloid cell activation involved in immune response (GO:0002275)3.32509073
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.29670407
54regulation of mast cell activation involved in immune response (GO:0033006)3.29168786
55regulation of gamma-delta T cell differentiation (GO:0045586)3.28711305
56response to protozoan (GO:0001562)3.25601028
57microglial cell activation (GO:0001774)3.20691559
58myeloid dendritic cell activation (GO:0001773)3.19051782
59positive T cell selection (GO:0043368)3.18426112
60positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.17853116
61positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.16863011
62regulation of myeloid leukocyte mediated immunity (GO:0002886)3.15938073
63response to muramyl dipeptide (GO:0032495)3.12886879
64germinal center formation (GO:0002467)3.12583276
65myeloid dendritic cell differentiation (GO:0043011)3.07649404
66cellular extravasation (GO:0045123)3.06492164
67positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.05969834
68regulation of T cell tolerance induction (GO:0002664)3.04981111
69negative thymic T cell selection (GO:0045060)3.04707006
70regulation of leukocyte degranulation (GO:0043300)3.04493481
71neutrophil activation (GO:0042119)3.03925124
72T cell selection (GO:0045058)3.03714510
73NIK/NF-kappaB signaling (GO:0038061)3.03494214
74antigen processing and presentation via MHC class Ib (GO:0002475)3.02291068
75respiratory burst (GO:0045730)3.01492122
76macrophage activation (GO:0042116)3.01269135
77granulocyte activation (GO:0036230)3.00622924
78regulation of alpha-beta T cell proliferation (GO:0046640)3.00198181
79antigen receptor-mediated signaling pathway (GO:0050851)2.99533461
80adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.98230574
81positive regulation of interferon-alpha production (GO:0032727)2.96973396
82response to host immune response (GO:0052572)2.96766106
83response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.96766106
84regulation of interferon-alpha production (GO:0032647)2.93675353
85production of molecular mediator involved in inflammatory response (GO:0002532)2.93465334
86regulation of T-helper 1 cell differentiation (GO:0045625)2.93319445
87positive regulation of leukocyte degranulation (GO:0043302)2.93020111
88regulation of hypersensitivity (GO:0002883)2.88004534
89glycosphingolipid catabolic process (GO:0046479)2.85748853
90lipopolysaccharide-mediated signaling pathway (GO:0031663)2.85733220
91production of molecular mediator of immune response (GO:0002440)2.85640173
92positive regulation of cellular amide metabolic process (GO:0034250)2.85622450
93regulation of tolerance induction (GO:0002643)2.85108800
94negative T cell selection (GO:0043383)2.83479038
95thymic T cell selection (GO:0045061)2.82705481
96regulation of T-helper 2 cell differentiation (GO:0045628)2.82356548
97positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.80752500
98T cell migration (GO:0072678)2.78046758
99positive regulation of macrophage cytokine production (GO:0060907)2.76314293
100negative regulation of lymphocyte mediated immunity (GO:0002707)2.76225766

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.45468150
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.25893292
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.97168103
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.71982838
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.62508689
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.43477921
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.40753601
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.29902984
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.27915580
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.24638679
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.90149781
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.89506522
13* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.65793256
14SPI1_23547873_ChIP-Seq_NB4_Human2.60037315
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.57889896
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.50983609
17VDR_24763502_ChIP-Seq_THP-1_Human2.46678472
18VDR_21846776_ChIP-Seq_THP-1_Human2.37886891
19E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.35510062
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.34287620
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.30707682
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.30702254
23MYB_26560356_Chip-Seq_TH2_Human2.28520408
24SPI1_23127762_ChIP-Seq_K562_Human2.23998043
25MYC_22102868_ChIP-Seq_BL_Human2.22871876
26RUNX_20019798_ChIP-Seq_JUKART_Human2.20558423
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.16940805
28SCL_19346495_ChIP-Seq_HPC-7_Human2.16611367
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.13338063
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.10061089
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08131078
32MAF_26560356_Chip-Seq_TH1_Human2.01780854
33VDR_24787735_ChIP-Seq_THP-1_Human1.97148447
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96470220
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.90926569
36MYB_26560356_Chip-Seq_TH1_Human1.90489748
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.87359040
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.77064086
39UTX_26944678_Chip-Seq_JUKART_Human1.68391499
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56550092
41GATA3_27048872_Chip-Seq_THYMUS_Human1.53523255
42CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52461537
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51280031
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45474482
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44720084
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41916546
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39019479
48MAF_26560356_Chip-Seq_TH2_Human1.37025791
49PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35093936
50* CIITA_25753668_ChIP-Seq_RAJI_Human1.34844590
51TCF7_22412390_ChIP-Seq_EML_Mouse1.34529728
52GATA1_22025678_ChIP-Seq_K562_Human1.33885544
53GATA3_26560356_Chip-Seq_TH2_Human1.31618569
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30300904
55CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29903183
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29499706
57PU_27001747_Chip-Seq_BMDM_Mouse1.28471905
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.27845062
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27749507
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24717114
61NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23559687
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21847312
63CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21683335
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20531124
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18835005
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18772239
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18068341
68SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17977419
69LXR_22292898_ChIP-Seq_THP-1_Human1.17052044
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15647544
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13879903
72BCL6_27268052_Chip-Seq_Bcells_Human1.13695270
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12809496
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11654369
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09780361
76PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06977648
77KDM2B_26808549_Chip-Seq_DND41_Human1.06121583
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03896908
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03409783
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02778450
81BCOR_27268052_Chip-Seq_Bcells_Human0.99125276
82GATA1_19941826_ChIP-Seq_K562_Human0.97985483
83SMAD_19615063_ChIP-ChIP_OVARY_Human0.95310873
84ELK3_25401928_ChIP-Seq_HUVEC_Human0.94423343
85* STAT1_20625510_ChIP-Seq_HELA_Human0.93008564
86GATA2_21666600_ChIP-Seq_HMVEC_Human0.92413488
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92216069
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89217177
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86130762
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83554002
91SMRT_27268052_Chip-Seq_Bcells_Human0.81562899
92TFEB_21752829_ChIP-Seq_HELA_Human0.81462685
93ELF1_20517297_ChIP-Seq_JURKAT_Human0.79531806
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78266606
95PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76406720
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76217663
97P300_27268052_Chip-Seq_Bcells_Human0.75447619
98SPI1_20517297_ChIP-Seq_HL60_Human0.74662494
99GATA2_19941826_ChIP-Seq_K562_Human0.71732783
100NCOR1_26117541_ChIP-Seq_K562_Human0.70976568

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.83937212
2MP0003303_peritoneal_inflammation3.78823644
3MP0005671_abnormal_response_to3.60247937
4MP0003436_decreased_susceptibility_to3.41692137
5MP0003724_increased_susceptibility_to3.37320780
6MP0005387_immune_system_phenotype3.27539926
7MP0001790_abnormal_immune_system3.27539926
8MP0001800_abnormal_humoral_immune3.21787826
9MP0000685_abnormal_immune_system3.12766419
10MP0005000_abnormal_immune_tolerance3.02693798
11MP0002419_abnormal_innate_immunity2.84356154
12MP0002452_abnormal_antigen_presenting2.83660103
13MP0009785_altered_susceptibility_to2.79667551
14MP0002148_abnormal_hypersensitivity_rea2.76475332
15MP0006082_CNS_inflammation2.74650077
16MP0005025_abnormal_response_to2.73877173
17MP0002723_abnormal_immune_serum2.69094117
18MP0005058_abnormal_lysosome_morphology2.52901630
19MP0002420_abnormal_adaptive_immunity2.47669339
20MP0001819_abnormal_immune_cell2.45906615
21MP0003172_abnormal_lysosome_physiology2.17389604
22MP0010155_abnormal_intestine_physiology2.12080310
23MP0003300_gastrointestinal_ulcer2.08184735
24MP0003191_abnormal_cellular_cholesterol1.89000221
25MP0001845_abnormal_inflammatory_respons1.88231037
26MP0005464_abnormal_platelet_physiology1.87055346
27MP0000716_abnormal_immune_system1.86030585
28MP0003763_abnormal_thymus_physiology1.81759419
29MP0002398_abnormal_bone_marrow1.77657470
30MP0003183_abnormal_peptide_metabolism1.77404957
31MP0002405_respiratory_system_inflammati1.76422534
32MP0001533_abnormal_skeleton_physiology1.75807397
33MP0009840_abnormal_foam_cell1.73443722
34MP0002166_altered_tumor_susceptibility1.71779411
35MP0002138_abnormal_hepatobiliary_system1.69618433
36MP0004947_skin_inflammation1.61379367
37MP0005310_abnormal_salivary_gland1.61245499
38MP0009333_abnormal_splenocyte_physiolog1.59443147
39MP0001853_heart_inflammation1.55893706
40MP0009764_decreased_sensitivity_to1.55396593
41MP0002139_abnormal_hepatobiliary_system1.55177420
42MP0008469_abnormal_protein_level1.54872267
43MP0000689_abnormal_spleen_morphology1.54619145
44MP0003075_altered_response_to1.50718296
45MP0000604_amyloidosis1.46128489
46MP0002429_abnormal_blood_cell1.45538152
47MP0003806_abnormal_nucleotide_metabolis1.38778852
48MP0005451_abnormal_body_composition1.38200840
49MP0002722_abnormal_immune_system1.36340307
50MP0002998_abnormal_bone_remodeling1.35340159
51MP0005166_decreased_susceptibility_to1.31701619
52MP0003866_abnormal_defecation1.31602596
53MP0000858_altered_metastatic_potential1.28833854
54MP0000343_altered_response_to1.25460328
55MP0001873_stomach_inflammation1.24514496
56MP0005397_hematopoietic_system_phenotyp1.21659566
57MP0001545_abnormal_hematopoietic_system1.21659566
58MP0000465_gastrointestinal_hemorrhage1.21633494
59MP0008260_abnormal_autophagy1.20043004
60MP0009278_abnormal_bone_marrow1.17303563
61MP0002006_tumorigenesis1.11067195
62MP0003828_pulmonary_edema1.10143587
63MP0008004_abnormal_stomach_pH1.05483943
64MP0003690_abnormal_glial_cell1.01786510
65MP0004510_myositis0.96948232
66MP0005360_urolithiasis0.95072125
67MP0001663_abnormal_digestive_system0.94878347
68MP0004883_abnormal_blood_vessel0.94308889
69MP0003448_altered_tumor_morphology0.93854621
70MP0000703_abnormal_thymus_morphology0.92079165
71MP0002396_abnormal_hematopoietic_system0.90047367
72MP0009763_increased_sensitivity_to0.85455192
73MP0001851_eye_inflammation0.85092653
74MP0000249_abnormal_blood_vessel0.85022589
75MP0005365_abnormal_bile_salt0.82371599
76MP0000490_abnormal_crypts_of0.80338388
77MP0002132_abnormal_respiratory_system0.79760783
78MP0005164_abnormal_response_to0.73815778
79MP0002933_joint_inflammation0.73743779
80MP0005075_abnormal_melanosome_morpholog0.73452541
81MP0002136_abnormal_kidney_physiology0.67945136
82MP0000015_abnormal_ear_pigmentation0.66768379
83MP0005390_skeleton_phenotype0.64506877
84MP0000920_abnormal_myelination0.62600769
85MP0003091_abnormal_cell_migration0.61781770
86MP0003795_abnormal_bone_structure0.61582951
87MP0002009_preneoplasia0.61093093
88MP0005165_increased_susceptibility_to0.60707942
89MP0003045_fibrosis0.58913831
90MP0000609_abnormal_liver_physiology0.58524126
91MP0003656_abnormal_erythrocyte_physiolo0.58156714
92MP0009643_abnormal_urine_homeostasis0.56644107
93MP0005584_abnormal_enzyme/coenzyme_acti0.55289930
94MP0005167_abnormal_blood-brain_barrier0.55180642
95MP0005085_abnormal_gallbladder_physiolo0.54387452
96MP0005381_digestive/alimentary_phenotyp0.53391282
97MP0005319_abnormal_enzyme/_coenzyme0.53271282
98MP0009765_abnormal_xenobiotic_induced0.52174800
99MP0008874_decreased_physiological_sensi0.51447838
100MP0004808_abnormal_hematopoietic_stem0.50652632

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.16625495
2Eczematoid dermatitis (HP:0000976)5.02458913
3Recurrent abscess formation (HP:0002722)4.98508237
4Abnormality of liposaccharide metabolism (HP:0010968)4.82411772
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.82411772
6Abnormality of glycolipid metabolism (HP:0010969)4.82411772
7Abnormality of macrophages (HP:0004311)4.67892445
8Meningitis (HP:0001287)4.30319572
9Mediastinal lymphadenopathy (HP:0100721)4.25970885
10Agammaglobulinemia (HP:0004432)4.21177045
11Systemic lupus erythematosus (HP:0002725)4.13535892
12Obstructive lung disease (HP:0006536)3.88042365
13Chronic obstructive pulmonary disease (HP:0006510)3.88042365
14Recurrent gram-negative bacterial infections (HP:0005420)3.83228368
15Vasculitis (HP:0002633)3.81006036
16Recurrent fungal infections (HP:0002841)3.75542990
17Increased cerebral lipofuscin (HP:0011813)3.69293711
18Recurrent skin infections (HP:0001581)3.68021885
19Gastrointestinal stroma tumor (HP:0100723)3.65123909
20Recurrent cutaneous fungal infections (HP:0011370)3.63055583
21Chronic mucocutaneous candidiasis (HP:0002728)3.63055583
22Myositis (HP:0100614)3.61241330
23Pulmonary infiltrates (HP:0002113)3.53656556
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.44000407
25Colitis (HP:0002583)3.40088170
26Recurrent viral infections (HP:0004429)3.39756879
27Panhypogammaglobulinemia (HP:0003139)3.38274356
28Orchitis (HP:0100796)3.37098153
29Retrobulbar optic neuritis (HP:0100654)3.28183124
30Optic neuritis (HP:0100653)3.28183124
31Vacuolated lymphocytes (HP:0001922)3.25567123
32Elevated erythrocyte sedimentation rate (HP:0003565)3.25288466
33Cellulitis (HP:0100658)3.23500260
34Hemoptysis (HP:0002105)3.08806065
35Urticaria (HP:0001025)3.08725809
36Increased neuronal autofluorescent lipopigment (HP:0002074)3.05079503
37Abnormality of the prostate (HP:0008775)3.04108078
38Dysostosis multiplex (HP:0000943)2.97806871
39Recurrent sinusitis (HP:0011108)2.97103310
40Inflammation of the large intestine (HP:0002037)2.96920395
41Encephalitis (HP:0002383)2.96905272
42Gastrointestinal infarctions (HP:0005244)2.94147480
43Restrictive lung disease (HP:0002091)2.93686774
44Stomatitis (HP:0010280)2.88378963
45Loss of speech (HP:0002371)2.83752050
46Chest pain (HP:0100749)2.83317975
47Gastrointestinal inflammation (HP:0004386)2.82533246
48Spontaneous hematomas (HP:0007420)2.80262901
49Osteomyelitis (HP:0002754)2.75979696
50Recurrent bronchitis (HP:0002837)2.75294856
51Autoimmune thrombocytopenia (HP:0001973)2.73019947
52Chronic diarrhea (HP:0002028)2.72535930
53Gingivitis (HP:0000230)2.68025584
54Lymphopenia (HP:0001888)2.64441628
55Increased IgE level (HP:0003212)2.60681847
56Abnormality of the pleura (HP:0002103)2.57952158
57Disinhibition (HP:0000734)2.56076093
58IgM deficiency (HP:0002850)2.54456420
59T lymphocytopenia (HP:0005403)2.54390106
60Glomerulonephritis (HP:0000099)2.53379112
61Recurrent pneumonia (HP:0006532)2.50026327
62Increased IgM level (HP:0003496)2.49489346
63Abnormality of T cell number (HP:0011839)2.47796807
64Abnormality of cells of the lymphoid lineage (HP:0012140)2.46890853
65Pustule (HP:0200039)2.46871219
66Purpura (HP:0000979)2.45922776
67Emphysema (HP:0002097)2.37826860
68Pulmonary embolism (HP:0002204)2.37054726
69Keratoconjunctivitis sicca (HP:0001097)2.36524962
70Skin rash (HP:0000988)2.35216411
71Recurrent lower respiratory tract infections (HP:0002783)2.32063686
72Abnormality of T cells (HP:0002843)2.31209894
73Malnutrition (HP:0004395)2.30570787
74Petechiae (HP:0000967)2.29173815
75Epistaxis (HP:0000421)2.27272480
76Amyloidosis (HP:0011034)2.24445468
77Gangrene (HP:0100758)2.24189667
78Verrucae (HP:0200043)2.22224140
79Papilloma (HP:0012740)2.22224140
80Abnormality of polysaccharide metabolism (HP:0011012)2.19182039
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.19182039
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.19182039
83Keratoconjunctivitis (HP:0001096)2.18825408
84Hypergammaglobulinemia (HP:0010702)2.17058774
85Polyneuropathy (HP:0001271)2.16557280
86Chronic otitis media (HP:0000389)2.15472215
87Leukocytosis (HP:0001974)2.14628143
88Pulmonary fibrosis (HP:0002206)2.13784780
89Mucopolysacchariduria (HP:0008155)2.13078132
90Urinary glycosaminoglycan excretion (HP:0003541)2.13078132
91Sepsis (HP:0100806)2.12876701
92Arterial thrombosis (HP:0004420)2.10178204
93Abnormality of T cell physiology (HP:0011840)2.10024505
94Abnormality of B cell number (HP:0010975)2.07639307
95Viral hepatitis (HP:0006562)2.07161535
96Arthralgia (HP:0002829)2.06373718
97IgG deficiency (HP:0004315)2.03677651
98Acrocyanosis (HP:0001063)2.03378164
99Gingival bleeding (HP:0000225)2.02897667
100Hematochezia (HP:0002573)2.01602196

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.85561722
2MAP4K14.36062022
3BLK4.00214189
4TYK23.22774069
5ERN12.95133308
6MAP3K142.68248843
7BMPR22.53853032
8CSF1R2.44249387
9IRAK42.27128173
10PRPF4B2.26383079
11SYK2.24179617
12FES2.12592943
13MAP3K132.12514357
14TBK12.10167406
15CSK2.08370438
16BTK2.02583627
17KIT1.97685191
18JAK31.93053717
19IKBKE1.86713889
20TXK1.74068628
21LYN1.71943771
22IKBKB1.71153779
23ZAP701.69333224
24JAK11.65465256
25FGR1.47722570
26HCK1.46352955
27MAP2K31.45675001
28TEC1.42585005
29MATK1.37019032
30TNK21.34043981
31GRK61.33285353
32ITK1.31462185
33SIK31.30716640
34TAOK31.29263054
35CDK191.27340959
36GRK71.24029518
37LCK1.23373555
38MAP3K31.14831569
39JAK21.14268913
40CDC42BPA1.13675725
41TGFBR21.13274549
42TESK21.12626521
43NME21.00650556
44ACVR1B0.98736436
45SIK20.94386706
46MAP3K110.92003756
47MARK30.89943250
48IRAK30.87373585
49PDK10.83562929
50MAP3K10.82935272
51PRKCQ0.78154210
52MAP3K100.75669058
53TAOK20.74581287
54TAOK10.71936299
55MAPK70.71624560
56STK100.70753837
57PDPK10.69730039
58IRAK10.68164118
59MAPK120.66108602
60PIK3CG0.65674746
61CHUK0.63315219
62NEK90.60087797
63PIM10.58985549
64FYN0.58160533
65FGFR40.56156699
66FGFR30.54532049
67CDK60.54293088
68ABL10.53699539
69IRAK20.53424514
70YES10.47402262
71RIPK10.46980725
72EPHB10.46314281
73CDK40.46051329
74LRRK20.43389562
75MAPK110.43127207
76HIPK20.40198083
77MAP3K50.39770144
78MOS0.37955989
79KDR0.37438616
80MAPKAPK20.36971312
81RPS6KC10.36628256
82RPS6KL10.36628256
83MARK20.35203767
84PRKCD0.35119789
85TRPM70.34524183
86EGFR0.33897977
87MAPK40.32458501
88MAP2K20.32457686
89TRIB30.31113247
90STK240.30343100
91IGF1R0.29563833
92RPS6KA60.28704925
93DDR20.28497264
94MAP2K60.27728759
95INSR0.25075744
96PRKD20.24881795
97SMG10.24439246
98TLK10.23841899
99KSR20.23710194
100CAMKK20.23469775

Predicted pathways (KEGG)

RankGene SetZ-score
1* Asthma_Homo sapiens_hsa053104.71024963
2* Allograft rejection_Homo sapiens_hsa053304.48796449
3* Autoimmune thyroid disease_Homo sapiens_hsa053204.19099563
4* Graft-versus-host disease_Homo sapiens_hsa053324.17562545
5* Intestinal immune network for IgA production_Homo sapiens_hsa046723.88486668
6* Staphylococcus aureus infection_Homo sapiens_hsa051503.69260862
7* Type I diabetes mellitus_Homo sapiens_hsa049403.42070759
8* Leishmaniasis_Homo sapiens_hsa051403.19292873
9* Antigen processing and presentation_Homo sapiens_hsa046122.84373786
10* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.77482252
11* Viral myocarditis_Homo sapiens_hsa054162.57289381
12Primary immunodeficiency_Homo sapiens_hsa053402.22960659
13* Rheumatoid arthritis_Homo sapiens_hsa053232.19269567
14* Tuberculosis_Homo sapiens_hsa051522.05409624
15Other glycan degradation_Homo sapiens_hsa005112.03423376
16Osteoclast differentiation_Homo sapiens_hsa043801.98021805
17B cell receptor signaling pathway_Homo sapiens_hsa046621.97317827
18* Toxoplasmosis_Homo sapiens_hsa051451.80346131
19Hematopoietic cell lineage_Homo sapiens_hsa046401.77110703
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.54862767
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54366537
22* Influenza A_Homo sapiens_hsa051641.53908802
23* Phagosome_Homo sapiens_hsa041451.52033328
24* Herpes simplex infection_Homo sapiens_hsa051681.44683004
25Lysosome_Homo sapiens_hsa041421.44225413
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16515823
27Pertussis_Homo sapiens_hsa051331.16482661
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11212765
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08705575
30* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04987323
31* Systemic lupus erythematosus_Homo sapiens_hsa053221.02065367
32Measles_Homo sapiens_hsa051620.98614632
33Legionellosis_Homo sapiens_hsa051340.93247627
34Glycosaminoglycan degradation_Homo sapiens_hsa005310.92263058
35Malaria_Homo sapiens_hsa051440.91935100
36Chemokine signaling pathway_Homo sapiens_hsa040620.90537598
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86867614
38T cell receptor signaling pathway_Homo sapiens_hsa046600.85355488
39TNF signaling pathway_Homo sapiens_hsa046680.82820337
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80312973
41Epstein-Barr virus infection_Homo sapiens_hsa051690.79900817
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78352153
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76726452
44Jak-STAT signaling pathway_Homo sapiens_hsa046300.73886324
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73404645
46African trypanosomiasis_Homo sapiens_hsa051430.69798722
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68151743
48Salmonella infection_Homo sapiens_hsa051320.67675391
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65401714
50Acute myeloid leukemia_Homo sapiens_hsa052210.62267136
51Hepatitis B_Homo sapiens_hsa051610.60265997
52Hepatitis C_Homo sapiens_hsa051600.60225590
53Apoptosis_Homo sapiens_hsa042100.59882624
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.56117221
55Platelet activation_Homo sapiens_hsa046110.55001765
56Shigellosis_Homo sapiens_hsa051310.52627288
57* HTLV-I infection_Homo sapiens_hsa051660.52142876
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45494844
59Renin-angiotensin system_Homo sapiens_hsa046140.45257461
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45199290
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41324661
62Collecting duct acid secretion_Homo sapiens_hsa049660.31296381
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.31103435
64Complement and coagulation cascades_Homo sapiens_hsa046100.28563734
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26856959
66Viral carcinogenesis_Homo sapiens_hsa052030.26734298
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25378253
68Arachidonic acid metabolism_Homo sapiens_hsa005900.24814766
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24080448
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.23118043
71Non-small cell lung cancer_Homo sapiens_hsa052230.22858560
72Prolactin signaling pathway_Homo sapiens_hsa049170.22259747
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.22089002
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20566840
75Pancreatic cancer_Homo sapiens_hsa052120.20133770
76VEGF signaling pathway_Homo sapiens_hsa043700.18874710
77Sphingolipid metabolism_Homo sapiens_hsa006000.18698393
78Endocytosis_Homo sapiens_hsa041440.18508838
79Vitamin digestion and absorption_Homo sapiens_hsa049770.18010918
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15939742
81Galactose metabolism_Homo sapiens_hsa000520.15896634
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.15018890
83Ether lipid metabolism_Homo sapiens_hsa005650.14549506
84Amoebiasis_Homo sapiens_hsa051460.14477508
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.14329761
86PPAR signaling pathway_Homo sapiens_hsa033200.13170377
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.12845684
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.12043760
89HIF-1 signaling pathway_Homo sapiens_hsa040660.10804858
90GnRH signaling pathway_Homo sapiens_hsa049120.10556406
91Chronic myeloid leukemia_Homo sapiens_hsa052200.10082620
92Mineral absorption_Homo sapiens_hsa049780.10060301
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.08549253
94Fructose and mannose metabolism_Homo sapiens_hsa000510.08413996
95Insulin resistance_Homo sapiens_hsa049310.08091324
96Renal cell carcinoma_Homo sapiens_hsa052110.06361507
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.05585553
98Notch signaling pathway_Homo sapiens_hsa043300.05508897
99Glycerolipid metabolism_Homo sapiens_hsa005610.03757744
100Fat digestion and absorption_Homo sapiens_hsa049750.03681788

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