HLA-DOA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)7.14287216
2antigen processing and presentation of endogenous antigen (GO:0019883)6.28087263
3B cell receptor signaling pathway (GO:0050853)5.90217151
4positive regulation of gamma-delta T cell activation (GO:0046645)5.85121097
5regulation of B cell receptor signaling pathway (GO:0050855)5.75666824
6B cell mediated immunity (GO:0019724)5.74361774
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.51960124
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.32274186
9interferon-gamma-mediated signaling pathway (GO:0060333)5.30237542
10positive thymic T cell selection (GO:0045059)5.27128653
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.23321804
12detection of bacterium (GO:0016045)5.08759172
13regulation of dendritic cell antigen processing and presentation (GO:0002604)4.85739571
14detection of other organism (GO:0098543)4.83093681
15positive regulation of antigen processing and presentation (GO:0002579)4.80060572
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.77735487
17negative regulation of cell killing (GO:0031342)4.77735487
18* regulation of antigen processing and presentation (GO:0002577)4.67856799
19positive regulation of B cell differentiation (GO:0045579)4.63251909
20* regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.62821191
21regulation of gamma-delta T cell activation (GO:0046643)4.29691029
22regulation of B cell differentiation (GO:0045577)4.21610749
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.20873858
24positive regulation by organism of defense response of other organism involved in symbiotic interact4.20873858
25modulation by symbiont of host immune response (GO:0052553)4.20873858
26positive regulation by symbiont of host defense response (GO:0052509)4.20873858
27modulation by symbiont of host defense response (GO:0052031)4.20873858
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.20873858
29T cell costimulation (GO:0031295)4.12851024
30negative thymic T cell selection (GO:0045060)4.12625612
31lymphocyte costimulation (GO:0031294)4.06700967
32positive T cell selection (GO:0043368)4.05311250
33cellular response to interferon-gamma (GO:0071346)4.05021830
34T-helper 1 type immune response (GO:0042088)3.97703170
35cellular response to type I interferon (GO:0071357)3.94069893
36type I interferon signaling pathway (GO:0060337)3.94069893
37response to type I interferon (GO:0034340)3.92784689
38defense response to protozoan (GO:0042832)3.87346530
39regulation of interferon-beta biosynthetic process (GO:0045357)3.85924563
40negative T cell selection (GO:0043383)3.83313811
41thymic T cell selection (GO:0045061)3.81648741
42antigen receptor-mediated signaling pathway (GO:0050851)3.79673681
43CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.75903483
44regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.75387076
45regulation of gamma-delta T cell differentiation (GO:0045586)3.75333658
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.69379108
47positive regulation of type 2 immune response (GO:0002830)3.68204077
48macrophage activation involved in immune response (GO:0002281)3.65474339
49T cell selection (GO:0045058)3.64440695
50positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.62415024
51detection of external biotic stimulus (GO:0098581)3.61883141
52response to interferon-gamma (GO:0034341)3.57262825
53B cell homeostasis (GO:0001782)3.53436363
54neutrophil activation involved in immune response (GO:0002283)3.53096845
55response to protozoan (GO:0001562)3.52783161
56positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.49827082
57regulation of alpha-beta T cell proliferation (GO:0046640)3.46852440
58adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.42654223
59B cell proliferation (GO:0042100)3.40899997
60production of molecular mediator of immune response (GO:0002440)3.36643043
61NIK/NF-kappaB signaling (GO:0038061)3.33155268
62regulation of T-helper 1 cell differentiation (GO:0045625)3.32259143
63positive regulation of interferon-alpha production (GO:0032727)3.31066798
64germinal center formation (GO:0002467)3.29395638
65T cell migration (GO:0072678)3.26993139
66regulation of B cell proliferation (GO:0030888)3.24800029
67positive regulation of B cell activation (GO:0050871)3.18498832
68response to peptidoglycan (GO:0032494)3.17235288
69positive regulation of B cell proliferation (GO:0030890)3.16322539
70adaptive immune response (GO:0002250)3.14995283
71detection of biotic stimulus (GO:0009595)3.14796152
72regulation of interferon-alpha production (GO:0032647)3.14421280
73positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.08484433
74positive regulation of immunoglobulin mediated immune response (GO:0002891)3.07685972
75positive regulation of B cell mediated immunity (GO:0002714)3.07685972
76positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.07505668
77myeloid dendritic cell activation (GO:0001773)3.06931677
78response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.05952903
79response to host immune response (GO:0052572)3.05952903
80chaperone mediated protein folding requiring cofactor (GO:0051085)3.02512295
81negative regulation of lymphocyte mediated immunity (GO:0002707)3.01682562
82positive regulation of mast cell activation (GO:0033005)3.01467730
83immune response-activating cell surface receptor signaling pathway (GO:0002429)3.01155210
84T cell receptor signaling pathway (GO:0050852)3.00986093
85positive regulation of humoral immune response (GO:0002922)2.99943816
86myeloid cell activation involved in immune response (GO:0002275)2.97484940
87mature B cell differentiation (GO:0002335)2.97254370
88antigen processing and presentation via MHC class Ib (GO:0002475)2.96770876
89regulation of mast cell degranulation (GO:0043304)2.96143979
90production of molecular mediator involved in inflammatory response (GO:0002532)2.93737343
91regulation of hypersensitivity (GO:0002883)2.92914980
92regulation of germinal center formation (GO:0002634)2.92231499
93response to muramyl dipeptide (GO:0032495)2.91426586
94respiratory burst (GO:0045730)2.91021559
95regulation of T cell mediated cytotoxicity (GO:0001914)2.90896730
96response to interleukin-15 (GO:0070672)2.90590918
97negative regulation of B cell proliferation (GO:0030889)2.89891229
98mast cell activation (GO:0045576)2.89662975
99regulation of mast cell activation (GO:0033003)2.87505581
100negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.87242709

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.69899962
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.56118045
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.29702481
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.20083926
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.14924452
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.88817759
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.73254116
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.59220862
9* MYC_22102868_ChIP-Seq_BL_Human3.45471137
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.28844122
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.07118041
12MYB_26560356_Chip-Seq_TH2_Human2.86328772
13E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.85974999
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.77988605
15SPI1_23547873_ChIP-Seq_NB4_Human2.61621889
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.53140913
17RUNX_20019798_ChIP-Seq_JUKART_Human2.50998611
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.46948810
19* CIITA_25753668_ChIP-Seq_RAJI_Human2.46128648
20MYB_26560356_Chip-Seq_TH1_Human2.43173049
21VDR_21846776_ChIP-Seq_THP-1_Human2.41162129
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.40733598
23SCL_19346495_ChIP-Seq_HPC-7_Human2.39426148
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.37758605
25MAF_26560356_Chip-Seq_TH1_Human2.32401366
26VDR_24763502_ChIP-Seq_THP-1_Human2.31112436
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24239824
28GATA1_22025678_ChIP-Seq_K562_Human2.05870754
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.02234605
30MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02137102
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.98510758
32UTX_26944678_Chip-Seq_JUKART_Human1.96074953
33SPI1_23127762_ChIP-Seq_K562_Human1.94755682
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.91194274
35GATA3_27048872_Chip-Seq_THYMUS_Human1.86038220
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81613752
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.80575960
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69729016
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.65756028
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63604268
41MAF_26560356_Chip-Seq_TH2_Human1.61702871
42GATA3_26560356_Chip-Seq_TH2_Human1.60545733
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58823498
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57339347
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57030875
46VDR_24787735_ChIP-Seq_THP-1_Human1.55013157
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48750428
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45770754
49VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.38565606
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36874871
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33755163
52NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32343383
53TCF7_22412390_ChIP-Seq_EML_Mouse1.30300446
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29513877
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25488217
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25038977
57PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22627654
58BCL6_27268052_Chip-Seq_Bcells_Human1.21785143
59Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20848597
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19323542
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16991430
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16655855
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13294591
64PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12144911
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10055114
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09916410
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.08997312
68SMRT_27268052_Chip-Seq_Bcells_Human1.08606288
69PU_27001747_Chip-Seq_BMDM_Mouse1.06942896
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06330673
71P300_27268052_Chip-Seq_Bcells_Human1.04837085
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03170269
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02895577
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02808452
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02597705
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02246911
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01868609
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.01501716
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01358535
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99419980
81BCOR_27268052_Chip-Seq_Bcells_Human0.99299860
82EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96906446
83KDM2B_26808549_Chip-Seq_DND41_Human0.93514791
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92464106
85ELF1_20517297_ChIP-Seq_JURKAT_Human0.89899350
86STAT1_20625510_ChIP-Seq_HELA_Human0.89818705
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87077258
88CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86642584
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86494592
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86042387
91PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85326911
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80863642
93SPI1_20517297_ChIP-Seq_HL60_Human0.79222827
94GATA1_19941826_ChIP-Seq_K562_Human0.78427242
95SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.77856183
96RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77014913
97VDR_23849224_ChIP-Seq_CD4+_Human0.76514367
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76462163
99LXR_22292898_ChIP-Seq_THP-1_Human0.75178523
100SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74728202

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.25377980
2MP0005671_abnormal_response_to4.12603638
3MP0001790_abnormal_immune_system3.96564262
4MP0005387_immune_system_phenotype3.96564262
5MP0001800_abnormal_humoral_immune3.95673550
6MP0000685_abnormal_immune_system3.91523814
7MP0003303_peritoneal_inflammation3.49742451
8MP0005000_abnormal_immune_tolerance3.26435542
9MP0002452_abnormal_antigen_presenting3.13048161
10MP0003436_decreased_susceptibility_to3.04229852
11MP0002723_abnormal_immune_serum2.99139459
12MP0002138_abnormal_hepatobiliary_system2.89072996
13MP0003724_increased_susceptibility_to2.82605276
14MP0002420_abnormal_adaptive_immunity2.81210783
15MP0001819_abnormal_immune_cell2.77066239
16MP0005025_abnormal_response_to2.69522928
17MP0009785_altered_susceptibility_to2.62788916
18MP0003763_abnormal_thymus_physiology2.60694443
19MP0002148_abnormal_hypersensitivity_rea2.53831666
20MP0002419_abnormal_innate_immunity2.50912534
21MP0002398_abnormal_bone_marrow2.31619547
22MP0000716_abnormal_immune_system2.24244702
23MP0002166_altered_tumor_susceptibility2.15123893
24MP0010155_abnormal_intestine_physiology2.07669111
25MP0000689_abnormal_spleen_morphology1.98081527
26MP0001845_abnormal_inflammatory_respons1.85196310
27MP0002405_respiratory_system_inflammati1.84804822
28MP0005464_abnormal_platelet_physiology1.82219236
29MP0002429_abnormal_blood_cell1.79148625
30MP0003300_gastrointestinal_ulcer1.77776775
31MP0005310_abnormal_salivary_gland1.72244093
32MP0002722_abnormal_immune_system1.71225599
33MP0003183_abnormal_peptide_metabolism1.61312958
34MP0001873_stomach_inflammation1.61154354
35MP0009333_abnormal_splenocyte_physiolog1.59596812
36MP0004947_skin_inflammation1.58345688
37MP0002006_tumorigenesis1.44854780
38MP0006082_CNS_inflammation1.42667920
39MP0003191_abnormal_cellular_cholesterol1.41929887
40MP0008469_abnormal_protein_level1.39209983
41MP0002396_abnormal_hematopoietic_system1.38377656
42MP0003866_abnormal_defecation1.36725681
43MP0005075_abnormal_melanosome_morpholog1.35622758
44MP0005645_abnormal_hypothalamus_physiol1.35068246
45MP0002139_abnormal_hepatobiliary_system1.34883145
46MP0003172_abnormal_lysosome_physiology1.34580132
47MP0001853_heart_inflammation1.34140591
48MP0009278_abnormal_bone_marrow1.33029405
49MP0000703_abnormal_thymus_morphology1.32703712
50MP0000465_gastrointestinal_hemorrhage1.29393090
51MP0001533_abnormal_skeleton_physiology1.28646516
52MP0005397_hematopoietic_system_phenotyp1.25159999
53MP0001545_abnormal_hematopoietic_system1.25159999
54MP0009764_decreased_sensitivity_to1.20860633
55MP0002009_preneoplasia1.12504883
56MP0002254_reproductive_system_inflammat1.07534805
57MP0008057_abnormal_DNA_replication1.03185666
58MP0002132_abnormal_respiratory_system1.00650013
59MP0001663_abnormal_digestive_system0.91205191
60MP0000490_abnormal_crypts_of0.85531568
61MP0005166_decreased_susceptibility_to0.83654304
62MP0002933_joint_inflammation0.83484488
63MP0004808_abnormal_hematopoietic_stem0.81545930
64MP0000858_altered_metastatic_potential0.80613682
65MP0001986_abnormal_taste_sensitivity0.78501952
66MP0002998_abnormal_bone_remodeling0.77394944
67MP0003806_abnormal_nucleotide_metabolis0.76936064
68MP0002019_abnormal_tumor_incidence0.76731187
69MP0000015_abnormal_ear_pigmentation0.76414600
70MP0000249_abnormal_blood_vessel0.75809370
71MP0009763_increased_sensitivity_to0.73528455
72MP0004381_abnormal_hair_follicle0.72099469
73MP0003045_fibrosis0.71526226
74MP0002136_abnormal_kidney_physiology0.71188253
75MP0008004_abnormal_stomach_pH0.71165546
76MP0001851_eye_inflammation0.69639210
77MP0003075_altered_response_to0.68615421
78MP0002693_abnormal_pancreas_physiology0.64597903
79MP0000604_amyloidosis0.64183196
80MP0004883_abnormal_blood_vessel0.62739916
81MP0004782_abnormal_surfactant_physiolog0.61199958
82MP0009840_abnormal_foam_cell0.58004385
83MP0003787_abnormal_imprinting0.56954309
84MP0003828_pulmonary_edema0.55899804
85MP0000372_irregular_coat_pigmentation0.54907121
86MP0000343_altered_response_to0.54738503
87MP0004510_myositis0.53038038
88MP0005058_abnormal_lysosome_morphology0.52188358
89MP0005451_abnormal_body_composition0.51489099
90MP0009643_abnormal_urine_homeostasis0.51353445
91MP0003252_abnormal_bile_duct0.51028619
92MP0005381_digestive/alimentary_phenotyp0.49868370
93MP0008874_decreased_physiological_sensi0.49496926
94MP0002277_abnormal_respiratory_mucosa0.48325046
95MP0003091_abnormal_cell_migration0.47995566
96MP0003448_altered_tumor_morphology0.47746829
97MP0009765_abnormal_xenobiotic_induced0.47743921
98MP0008961_abnormal_basal_metabolism0.46567238
99MP0005174_abnormal_tail_pigmentation0.43574916
100MP0008995_early_reproductive_senescence0.43164259

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.93612867
2Gastrointestinal stroma tumor (HP:0100723)5.61224996
3Meningitis (HP:0001287)5.39561362
4Panhypogammaglobulinemia (HP:0003139)5.18517483
5Abnormal delayed hypersensitivity skin test (HP:0002963)4.83618659
6Recurrent sinusitis (HP:0011108)4.72906947
7Mediastinal lymphadenopathy (HP:0100721)4.69887573
8Recurrent bacterial skin infections (HP:0005406)4.66357319
9Eczematoid dermatitis (HP:0000976)4.61179527
10Colitis (HP:0002583)4.54124044
11Vasculitis (HP:0002633)4.48745713
12Recurrent bronchitis (HP:0002837)4.48669779
13Recurrent abscess formation (HP:0002722)4.35166973
14Recurrent cutaneous fungal infections (HP:0011370)4.29143242
15Chronic mucocutaneous candidiasis (HP:0002728)4.29143242
16Recurrent viral infections (HP:0004429)4.23045866
17Recurrent fungal infections (HP:0002841)4.13684500
18Cellulitis (HP:0100658)4.12501641
19IgM deficiency (HP:0002850)4.02072036
20Lymphopenia (HP:0001888)3.98587014
21Inflammation of the large intestine (HP:0002037)3.83600861
22Abnormality of macrophages (HP:0004311)3.79863855
23Abnormality of cells of the lymphoid lineage (HP:0012140)3.73771939
24Abnormality of the prostate (HP:0008775)3.73186608
25Recurrent skin infections (HP:0001581)3.69104546
26Pulmonary infiltrates (HP:0002113)3.68260132
27Gastrointestinal inflammation (HP:0004386)3.66475108
28Obstructive lung disease (HP:0006536)3.55791459
29Chronic obstructive pulmonary disease (HP:0006510)3.55791459
30Restrictive lung disease (HP:0002091)3.48204134
31Encephalitis (HP:0002383)3.47846776
32IgA deficiency (HP:0002720)3.44291258
33Osteomyelitis (HP:0002754)3.42582361
34IgG deficiency (HP:0004315)3.38445093
35Chronic otitis media (HP:0000389)3.37965267
36Papilloma (HP:0012740)3.37863606
37Verrucae (HP:0200043)3.37863606
38Urticaria (HP:0001025)3.33640856
39Recurrent pneumonia (HP:0006532)3.28807814
40Emphysema (HP:0002097)3.27709062
41Recurrent lower respiratory tract infections (HP:0002783)3.26181269
42Elevated erythrocyte sedimentation rate (HP:0003565)3.23578503
43Abnormality of T cell physiology (HP:0011840)3.22132003
44Recurrent gram-negative bacterial infections (HP:0005420)3.19888847
45Abnormality of B cell number (HP:0010975)3.18350465
46Myositis (HP:0100614)3.16514878
47Abnormality of T cells (HP:0002843)3.07006722
48Systemic lupus erythematosus (HP:0002725)3.02377757
49Optic neuritis (HP:0100653)3.01605073
50Retrobulbar optic neuritis (HP:0100654)3.01605073
51Chronic diarrhea (HP:0002028)2.98735077
52B lymphocytopenia (HP:0010976)2.97528860
53Gastrointestinal infarctions (HP:0005244)2.90639689
54Chronic sinusitis (HP:0011109)2.90205939
55Chest pain (HP:0100749)2.90035033
56Increased IgE level (HP:0003212)2.87298333
57Hemoptysis (HP:0002105)2.87043060
58Skin rash (HP:0000988)2.85404059
59Bronchitis (HP:0012387)2.83997706
60Orchitis (HP:0100796)2.82850974
61Viral hepatitis (HP:0006562)2.80782571
62Increased IgM level (HP:0003496)2.70298401
63Abnormality of the pleura (HP:0002103)2.69136884
64Pustule (HP:0200039)2.68074274
65Sepsis (HP:0100806)2.67181918
66Abnormality of T cell number (HP:0011839)2.64183212
67T lymphocytopenia (HP:0005403)2.60994383
68Spontaneous hematomas (HP:0007420)2.57741425
69Pulmonary fibrosis (HP:0002206)2.55073909
70Stomatitis (HP:0010280)2.50027278
71Lymphoma (HP:0002665)2.47752034
72Abnormality of male internal genitalia (HP:0000022)2.43598754
73Skin ulcer (HP:0200042)2.31537608
74Hypergammaglobulinemia (HP:0010702)2.30380236
75Granulocytopenia (HP:0001913)2.28614447
76Xerostomia (HP:0000217)2.27177072
77Pulmonary embolism (HP:0002204)2.26586195
78Arthralgia (HP:0002829)2.25772864
79Premature loss of primary teeth (HP:0006323)2.25144659
80Leukopenia (HP:0001882)2.24769083
81Prostate neoplasm (HP:0100787)2.23651743
82Epistaxis (HP:0000421)2.18067728
83Recurrent otitis media (HP:0000403)2.15539158
84Gingivitis (HP:0000230)2.15190504
85Hypertensive crisis (HP:0100735)2.14657213
86Keratoconjunctivitis sicca (HP:0001097)2.14570516
87Gangrene (HP:0100758)2.13942592
88Leukocytosis (HP:0001974)2.08714177
89Abnormality of the peritoneum (HP:0002585)2.04133996
90Keratoconjunctivitis (HP:0001096)2.03814639
91Neutropenia (HP:0001875)2.03131866
92Eosinophilia (HP:0001880)2.01619220
93Prolonged bleeding time (HP:0003010)1.97047128
94Petechiae (HP:0000967)1.94956071
95Basal cell carcinoma (HP:0002671)1.93732433
96Glomerulonephritis (HP:0000099)1.92529456
97Arterial thrombosis (HP:0004420)1.90734583
98Autoimmune hemolytic anemia (HP:0001890)1.89428521
99Stomach cancer (HP:0012126)1.87630649
100Abnormality of small intestinal villus morphology (HP:0011472)1.86905595

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.65806089
2RIPK44.88730211
3BLK3.60521109
4ERN12.69413025
5TYK22.64359561
6SYK2.62808679
7CSF1R2.55205457
8IRAK42.44980440
9BTK2.43530215
10KIT2.40818711
11BMPR22.32408783
12MAP3K142.30833262
13PRPF4B2.08506984
14IKBKE2.06604109
15JAK31.94716574
16CDK191.93670279
17MAP3K101.90136789
18TBK11.88174205
19LYN1.87127666
20IKBKB1.79053691
21TEC1.77665736
22FES1.77443666
23MAP3K131.75582579
24JAK11.58441800
25TAOK31.58347882
26TXK1.57067261
27SIK31.51453664
28TNK21.47121843
29CSK1.45489468
30HCK1.45444471
31ITK1.40273776
32GRK61.38258815
33SIK21.35609261
34TLK11.27308168
35LCK1.22791843
36MATK1.19767776
37PRKCQ1.10805347
38ZAP701.02482212
39FGR0.96286722
40JAK20.96127723
41CDC42BPA0.93953027
42FGFR40.93906014
43PASK0.91044204
44MARK30.89674711
45CDK40.84668856
46IRAK10.84589928
47STK100.83930783
48PIM10.81633593
49HIPK20.78491582
50CHUK0.77862292
51MAPK70.77595714
52SMG10.72933245
53MAPK120.72746437
54FGFR30.72528057
55PDK10.69398121
56MAP2K30.68458065
57MAPK110.68379371
58MST40.65818689
59NLK0.60574593
60NEK90.59100625
61LRRK20.53131930
62MAP3K110.51586030
63ABL10.50678925
64MAP3K10.50648109
65ZAK0.50289484
66FYN0.49849113
67MAP2K20.48375057
68TESK20.48131748
69KDR0.47601701
70RPS6KA50.47042528
71YES10.44654301
72VRK10.44635839
73CDK120.44409573
74EPHA30.39862620
75OXSR10.39716442
76PIK3CG0.38057011
77GRK10.37985858
78MAPK40.37471793
79PRKD20.36576489
80EIF2AK30.36167884
81MAPKAPK20.36050099
82PRKCD0.34705177
83CDK60.34291198
84PDPK10.34278629
85TRPM70.32767099
86INSR0.32676067
87MARK20.30888059
88DAPK30.30136932
89EGFR0.29920216
90GRK70.29294177
91MAPK30.29049235
92IGF1R0.28469148
93CDK90.28043549
94BCKDK0.27452826
95MAP3K70.27431915
96ADRBK20.26893013
97ACVR1B0.26815251
98ALK0.26452360
99RPS6KL10.26003923
100RPS6KC10.26003923

Predicted pathways (KEGG)

RankGene SetZ-score
1* Asthma_Homo sapiens_hsa053105.23054666
2* Allograft rejection_Homo sapiens_hsa053305.06958580
3* Autoimmune thyroid disease_Homo sapiens_hsa053204.80075353
4* Graft-versus-host disease_Homo sapiens_hsa053324.65498223
5* Intestinal immune network for IgA production_Homo sapiens_hsa046724.63741496
6* Type I diabetes mellitus_Homo sapiens_hsa049403.97689932
7* Staphylococcus aureus infection_Homo sapiens_hsa051503.50938227
8Primary immunodeficiency_Homo sapiens_hsa053403.15399756
9* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.03671781
10* Leishmaniasis_Homo sapiens_hsa051403.02741284
11* Antigen processing and presentation_Homo sapiens_hsa046122.99416777
12* Viral myocarditis_Homo sapiens_hsa054162.81311230
13B cell receptor signaling pathway_Homo sapiens_hsa046622.31284705
14* Systemic lupus erythematosus_Homo sapiens_hsa053221.86529171
15* Rheumatoid arthritis_Homo sapiens_hsa053231.83670208
16Hematopoietic cell lineage_Homo sapiens_hsa046401.76985998
17* Tuberculosis_Homo sapiens_hsa051521.69784526
18* Herpes simplex infection_Homo sapiens_hsa051681.66877401
19* Toxoplasmosis_Homo sapiens_hsa051451.65958324
20* Influenza A_Homo sapiens_hsa051641.54963517
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.52393147
22Osteoclast differentiation_Homo sapiens_hsa043801.38845483
23* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.22670038
24* Phagosome_Homo sapiens_hsa041451.10770045
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08757191
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03152388
27Epstein-Barr virus infection_Homo sapiens_hsa051691.01324831
28Measles_Homo sapiens_hsa051621.00430304
29T cell receptor signaling pathway_Homo sapiens_hsa046600.80219513
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79681624
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79460414
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79253108
33Chemokine signaling pathway_Homo sapiens_hsa040620.74543324
34Jak-STAT signaling pathway_Homo sapiens_hsa046300.73588704
35Other glycan degradation_Homo sapiens_hsa005110.73586495
36NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71461970
37* HTLV-I infection_Homo sapiens_hsa051660.68758516
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65970789
39Pertussis_Homo sapiens_hsa051330.61923546
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59450189
41Hepatitis B_Homo sapiens_hsa051610.56979213
42African trypanosomiasis_Homo sapiens_hsa051430.52911433
43Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49327386
44Viral carcinogenesis_Homo sapiens_hsa052030.49018983
45TNF signaling pathway_Homo sapiens_hsa046680.48985274
46Acute myeloid leukemia_Homo sapiens_hsa052210.45511341
47Malaria_Homo sapiens_hsa051440.44981843
48Apoptosis_Homo sapiens_hsa042100.44281371
49Platelet activation_Homo sapiens_hsa046110.43236146
50Hepatitis C_Homo sapiens_hsa051600.42002634
51Legionellosis_Homo sapiens_hsa051340.39135533
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37948750
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.35897177
54Lysosome_Homo sapiens_hsa041420.35462376
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31423791
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.25189489
57Linoleic acid metabolism_Homo sapiens_hsa005910.22198347
58Alcoholism_Homo sapiens_hsa050340.21561005
59Arachidonic acid metabolism_Homo sapiens_hsa005900.21142075
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20286934
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20028027
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17499195
63Shigellosis_Homo sapiens_hsa051310.17224431
64Caffeine metabolism_Homo sapiens_hsa002320.16528668
65Ribosome_Homo sapiens_hsa030100.15851017
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.15729954
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.14714656
68Renin-angiotensin system_Homo sapiens_hsa046140.12483849
69Ether lipid metabolism_Homo sapiens_hsa005650.11465026
70Base excision repair_Homo sapiens_hsa034100.10289131
71Prolactin signaling pathway_Homo sapiens_hsa049170.09867373
72Non-small cell lung cancer_Homo sapiens_hsa052230.09860014
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.08956853
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.07983342
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.03940145
76Salmonella infection_Homo sapiens_hsa051320.03487853
77Pancreatic cancer_Homo sapiens_hsa052120.03315566
78ABC transporters_Homo sapiens_hsa020100.03200622
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.03166477
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.02331168
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.00512700
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.00262915
83Tryptophan metabolism_Homo sapiens_hsa00380-0.0769911
84Choline metabolism in cancer_Homo sapiens_hsa05231-0.0732104
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.0644299
86Complement and coagulation cascades_Homo sapiens_hsa04610-0.0614761
87Endocytosis_Homo sapiens_hsa04144-0.0570935
88Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0550061
89HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0483073
90Chronic myeloid leukemia_Homo sapiens_hsa05220-0.0389573
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0371533
92VEGF signaling pathway_Homo sapiens_hsa04370-0.0368447
93MAPK signaling pathway_Homo sapiens_hsa04010-0.0253142
94Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0227902
95Vitamin digestion and absorption_Homo sapiens_hsa04977-0.0185501
96Notch signaling pathway_Homo sapiens_hsa04330-0.0164430
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0159763
98Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0124437
99Homologous recombination_Homo sapiens_hsa03440-0.0095193
100Glycerolipid metabolism_Homo sapiens_hsa00561-0.0024797

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