HLA-DPA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)6.58000251
2antigen processing and presentation of endogenous antigen (GO:0019883)5.21553794
3B cell mediated immunity (GO:0019724)5.17348366
4* interferon-gamma-mediated signaling pathway (GO:0060333)5.08549872
5regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.05314302
6positive regulation of gamma-delta T cell activation (GO:0046645)4.92910868
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.80933873
8regulation of antigen processing and presentation (GO:0002577)4.71770460
9detection of bacterium (GO:0016045)4.64676115
10detection of other organism (GO:0098543)4.57005105
11positive regulation of antigen processing and presentation (GO:0002579)4.54608729
12regulation of dendritic cell antigen processing and presentation (GO:0002604)4.52096344
13neutrophil activation involved in immune response (GO:0002283)4.51045880
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.47844176
15regulation of B cell receptor signaling pathway (GO:0050855)4.35129162
16modulation by symbiont of host defense response (GO:0052031)4.32692930
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.32692930
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.32692930
19positive regulation by organism of defense response of other organism involved in symbiotic interact4.32692930
20modulation by symbiont of host immune response (GO:0052553)4.32692930
21positive regulation by symbiont of host defense response (GO:0052509)4.32692930
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.28241961
23response to peptidoglycan (GO:0032494)4.14615334
24macrophage activation involved in immune response (GO:0002281)4.12319948
25positive thymic T cell selection (GO:0045059)4.11539493
26T-helper 1 type immune response (GO:0042088)4.08157525
27* cellular response to interferon-gamma (GO:0071346)4.00515161
28positive regulation of mast cell activation (GO:0033005)3.99095254
29negative regulation of cell killing (GO:0031342)3.96422838
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.96422838
31positive regulation of mast cell activation involved in immune response (GO:0033008)3.94691517
32positive regulation of mast cell degranulation (GO:0043306)3.94691517
33positive regulation of type 2 immune response (GO:0002830)3.87418648
34* T cell costimulation (GO:0031295)3.80166490
35detection of external biotic stimulus (GO:0098581)3.78293005
36B cell receptor signaling pathway (GO:0050853)3.75204483
37* lymphocyte costimulation (GO:0031294)3.74540043
38regulation of interferon-beta biosynthetic process (GO:0045357)3.61691443
39* response to interferon-gamma (GO:0034341)3.60634578
40regulation of mast cell degranulation (GO:0043304)3.58974928
41positive regulation of B cell differentiation (GO:0045579)3.57656248
42negative regulation of interleukin-12 production (GO:0032695)3.55990066
43regulation of hypersensitivity (GO:0002883)3.53257762
44type I interferon signaling pathway (GO:0060337)3.52356549
45cellular response to type I interferon (GO:0071357)3.52356549
46regulation of gamma-delta T cell activation (GO:0046643)3.50309914
47response to type I interferon (GO:0034340)3.49139460
48microglial cell activation (GO:0001774)3.41718874
49defense response to protozoan (GO:0042832)3.39830488
50positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.38236727
51regulation of mast cell activation (GO:0033003)3.34233254
52myeloid cell activation involved in immune response (GO:0002275)3.30876137
53detection of biotic stimulus (GO:0009595)3.30752886
54regulation of T cell tolerance induction (GO:0002664)3.30329776
55regulation of mast cell activation involved in immune response (GO:0033006)3.28472469
56positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.27390759
57myeloid dendritic cell activation (GO:0001773)3.25025828
58response to protozoan (GO:0001562)3.18113089
59antigen processing and presentation via MHC class Ib (GO:0002475)3.16986067
60negative thymic T cell selection (GO:0045060)3.16305214
61regulation of tolerance induction (GO:0002643)3.16113958
62regulation of alpha-beta T cell proliferation (GO:0046640)3.14288667
63response to host immune response (GO:0052572)3.12858961
64response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.12858961
65regulation of B cell differentiation (GO:0045577)3.08830507
66production of molecular mediator of immune response (GO:0002440)3.08134356
67regulation of T-helper 1 cell differentiation (GO:0045625)3.08021423
68detection of molecule of bacterial origin (GO:0032490)3.07824493
69adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.07627936
70myeloid dendritic cell differentiation (GO:0043011)3.07321767
71regulation of myeloid leukocyte mediated immunity (GO:0002886)3.05793356
72positive T cell selection (GO:0043368)3.05758110
73positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.04973398
74positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.04352087
75positive regulation of interferon-alpha production (GO:0032727)3.04337157
76negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.02488300
77regulation of interferon-alpha production (GO:0032647)3.01933070
78positive regulation of leukocyte degranulation (GO:0043302)3.00841462
79* antigen receptor-mediated signaling pathway (GO:0050851)2.97128262
80regulation of type 2 immune response (GO:0002828)2.95686246
81regulation of T-helper 2 cell differentiation (GO:0045628)2.95457341
82cellular extravasation (GO:0045123)2.95189263
83germinal center formation (GO:0002467)2.94679070
84regulation of gamma-delta T cell differentiation (GO:0045586)2.94161182
85negative T cell selection (GO:0043383)2.93129780
86regulation of leukocyte degranulation (GO:0043300)2.93049693
87response to muramyl dipeptide (GO:0032495)2.92433425
88T cell migration (GO:0072678)2.91118714
89Arp2/3 complex-mediated actin nucleation (GO:0034314)2.90616739
90macrophage activation (GO:0042116)2.89644128
91positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.88928752
92regulation of inflammatory response to antigenic stimulus (GO:0002861)2.88693410
93neutrophil activation (GO:0042119)2.87186748
94positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.87060550
95lipopolysaccharide-mediated signaling pathway (GO:0031663)2.86690771
96T cell selection (GO:0045058)2.86623040
97granulocyte activation (GO:0036230)2.83798953
98response to host (GO:0075136)2.81369878
99response to host defenses (GO:0052200)2.81369878
100response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.81369878

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.73139212
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.77299560
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.01460619
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.09309959
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.59270362
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.56157939
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.43978982
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.30289129
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.23575982
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.20891312
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.81190743
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.79348794
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.73458505
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.59889611
15SPI1_23547873_ChIP-Seq_NB4_Human2.59066098
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.50856841
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.41384685
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.40843982
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40126321
20SCL_19346495_ChIP-Seq_HPC-7_Human2.34675362
21MYB_26560356_Chip-Seq_TH2_Human2.33109853
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.30079831
23VDR_24763502_ChIP-Seq_THP-1_Human2.25457942
24RUNX_20019798_ChIP-Seq_JUKART_Human2.21822203
25SPI1_23127762_ChIP-Seq_K562_Human2.15652811
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.09363633
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.04803743
28VDR_21846776_ChIP-Seq_THP-1_Human2.04483676
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.00693856
30MYC_22102868_ChIP-Seq_BL_Human1.93990014
31MAF_26560356_Chip-Seq_TH1_Human1.89917806
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.89903500
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88446413
34MYB_26560356_Chip-Seq_TH1_Human1.85597655
35VDR_24787735_ChIP-Seq_THP-1_Human1.83906842
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.79829518
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78846881
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.67716058
39GATA3_27048872_Chip-Seq_THYMUS_Human1.59208559
40UTX_26944678_Chip-Seq_JUKART_Human1.55356442
41GATA1_22025678_ChIP-Seq_K562_Human1.53768164
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51470261
43CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50299833
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49382372
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46702902
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41967034
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41918252
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41266640
49GATA3_26560356_Chip-Seq_TH2_Human1.40345030
50* CIITA_25753668_ChIP-Seq_RAJI_Human1.35955098
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35748999
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31910070
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29276279
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28093271
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25155134
56MAF_26560356_Chip-Seq_TH2_Human1.23241955
57CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22411963
58PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22057227
59PU_27001747_Chip-Seq_BMDM_Mouse1.21363269
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21300535
61PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18863079
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.16645635
63CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15999578
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14576570
65PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13931699
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13683761
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13515870
68TCF7_22412390_ChIP-Seq_EML_Mouse1.11177568
69SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10963295
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10928235
71BCL6_27268052_Chip-Seq_Bcells_Human1.09048732
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.08100117
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03456457
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02515283
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01594029
76STAT1_20625510_ChIP-Seq_HELA_Human1.01386951
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99373196
78LXR_22292898_ChIP-Seq_THP-1_Human0.97084073
79GATA2_21666600_ChIP-Seq_HMVEC_Human0.92051221
80BCOR_27268052_Chip-Seq_Bcells_Human0.91611188
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89909214
82GATA1_19941826_ChIP-Seq_K562_Human0.87973027
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87615268
84SPI1_20517297_ChIP-Seq_HL60_Human0.85335437
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85242943
86SMRT_27268052_Chip-Seq_Bcells_Human0.82325423
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81336839
88ELF1_20517297_ChIP-Seq_JURKAT_Human0.80286477
89EGR1_23403033_ChIP-Seq_LIVER_Mouse0.80012755
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79850118
91KDM2B_26808549_Chip-Seq_DND41_Human0.79775015
92EGR1_19032775_ChIP-ChIP_M12_Human0.78751879
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78063350
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77542543
95P300_27268052_Chip-Seq_Bcells_Human0.75328544
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75152954
97ELK3_25401928_ChIP-Seq_HUVEC_Human0.73784426
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72840923
99PPARA_22158963_ChIP-Seq_LIVER_Mouse0.70721504
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70442435

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.23599028
2MP0005671_abnormal_response_to3.89227487
3MP0003303_peritoneal_inflammation3.62631488
4MP0003724_increased_susceptibility_to3.32207370
5MP0003436_decreased_susceptibility_to3.26578796
6MP0001790_abnormal_immune_system3.26178638
7MP0005387_immune_system_phenotype3.26178638
8MP0001800_abnormal_humoral_immune3.21557630
9MP0000685_abnormal_immune_system3.10633161
10MP0005000_abnormal_immune_tolerance3.03580303
11MP0002148_abnormal_hypersensitivity_rea3.02226399
12MP0009785_altered_susceptibility_to3.00988811
13MP0002452_abnormal_antigen_presenting2.84383629
14MP0005025_abnormal_response_to2.79825625
15MP0002419_abnormal_innate_immunity2.78749346
16MP0006082_CNS_inflammation2.68677737
17MP0002723_abnormal_immune_serum2.68019763
18MP0001819_abnormal_immune_cell2.44664558
19MP0002420_abnormal_adaptive_immunity2.43677064
20MP0010155_abnormal_intestine_physiology2.21760192
21MP0003300_gastrointestinal_ulcer2.14743752
22MP0005058_abnormal_lysosome_morphology2.06848201
23MP0005464_abnormal_platelet_physiology1.95912677
24MP0003172_abnormal_lysosome_physiology1.91465283
25MP0001845_abnormal_inflammatory_respons1.89613428
26MP0002166_altered_tumor_susceptibility1.87464509
27MP0000716_abnormal_immune_system1.84829853
28MP0002398_abnormal_bone_marrow1.76813307
29MP0003763_abnormal_thymus_physiology1.76703289
30MP0002405_respiratory_system_inflammati1.72435866
31MP0001533_abnormal_skeleton_physiology1.69835322
32MP0009764_decreased_sensitivity_to1.69215968
33MP0003075_altered_response_to1.68568619
34MP0003191_abnormal_cellular_cholesterol1.63048662
35MP0004947_skin_inflammation1.60209517
36MP0009333_abnormal_splenocyte_physiolog1.59268935
37MP0008469_abnormal_protein_level1.59189551
38MP0003183_abnormal_peptide_metabolism1.58974232
39MP0001853_heart_inflammation1.56621278
40MP0005166_decreased_susceptibility_to1.55592559
41MP0003806_abnormal_nucleotide_metabolis1.55371734
42MP0002138_abnormal_hepatobiliary_system1.53107910
43MP0000689_abnormal_spleen_morphology1.46384792
44MP0003866_abnormal_defecation1.45808001
45MP0002429_abnormal_blood_cell1.45448417
46MP0002139_abnormal_hepatobiliary_system1.42733256
47MP0000465_gastrointestinal_hemorrhage1.36205170
48MP0005451_abnormal_body_composition1.35413177
49MP0005310_abnormal_salivary_gland1.31740470
50MP0000343_altered_response_to1.31075515
51MP0002722_abnormal_immune_system1.30419037
52MP0002006_tumorigenesis1.29014166
53MP0009840_abnormal_foam_cell1.27014500
54MP0002998_abnormal_bone_remodeling1.26591661
55MP0005397_hematopoietic_system_phenotyp1.25838081
56MP0001545_abnormal_hematopoietic_system1.25838081
57MP0001873_stomach_inflammation1.25675903
58MP0000858_altered_metastatic_potential1.24271196
59MP0008004_abnormal_stomach_pH1.18046016
60MP0009278_abnormal_bone_marrow1.09745811
61MP0002396_abnormal_hematopoietic_system1.08355870
62MP0000604_amyloidosis1.06626138
63MP0003828_pulmonary_edema1.02441109
64MP0003448_altered_tumor_morphology1.01515027
65MP0009763_increased_sensitivity_to0.94794223
66MP0001663_abnormal_digestive_system0.94424160
67MP0008260_abnormal_autophagy0.91424216
68MP0000249_abnormal_blood_vessel0.85685692
69MP0000703_abnormal_thymus_morphology0.84890235
70MP0005165_increased_susceptibility_to0.83071842
71MP0005360_urolithiasis0.81989920
72MP0003690_abnormal_glial_cell0.81495167
73MP0004510_myositis0.80873444
74MP0001851_eye_inflammation0.79539274
75MP0005075_abnormal_melanosome_morpholog0.78375458
76MP0004883_abnormal_blood_vessel0.72849965
77MP0003045_fibrosis0.72673833
78MP0000015_abnormal_ear_pigmentation0.70919413
79MP0002132_abnormal_respiratory_system0.70127571
80MP0002933_joint_inflammation0.69556356
81MP0000490_abnormal_crypts_of0.69017834
82MP0005164_abnormal_response_to0.67393100
83MP0002136_abnormal_kidney_physiology0.67215016
84MP0002009_preneoplasia0.66763982
85MP0009765_abnormal_xenobiotic_induced0.66240158
86MP0000920_abnormal_myelination0.64745459
87MP0005390_skeleton_phenotype0.63308115
88MP0009643_abnormal_urine_homeostasis0.62816874
89MP0004808_abnormal_hematopoietic_stem0.61036454
90MP0005584_abnormal_enzyme/coenzyme_acti0.59874640
91MP0005365_abnormal_bile_salt0.58640921
92MP0003795_abnormal_bone_structure0.58370615
93MP0003091_abnormal_cell_migration0.58295543
94MP0008874_decreased_physiological_sensi0.56653361
95MP0005319_abnormal_enzyme/_coenzyme0.56516931
96MP0003252_abnormal_bile_duct0.54780534
97MP0000609_abnormal_liver_physiology0.54032684
98MP0005167_abnormal_blood-brain_barrier0.53549717
99MP0005381_digestive/alimentary_phenotyp0.53408410
100MP0005535_abnormal_body_temperature0.49799009

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.87449685
2Recurrent abscess formation (HP:0002722)4.76151071
3Eczematoid dermatitis (HP:0000976)4.69371037
4Meningitis (HP:0001287)4.47581691
5Systemic lupus erythematosus (HP:0002725)4.42848222
6Abnormality of macrophages (HP:0004311)4.38252090
7Chronic obstructive pulmonary disease (HP:0006510)4.28872249
8Obstructive lung disease (HP:0006536)4.28872249
9Agammaglobulinemia (HP:0004432)4.20568502
10Mediastinal lymphadenopathy (HP:0100721)4.14204837
11Vasculitis (HP:0002633)4.07091974
12Recurrent cutaneous fungal infections (HP:0011370)3.82818529
13Chronic mucocutaneous candidiasis (HP:0002728)3.82818529
14Abnormality of liposaccharide metabolism (HP:0010968)3.76327495
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.76327495
16Abnormality of glycolipid metabolism (HP:0010969)3.76327495
17Pulmonary infiltrates (HP:0002113)3.73491772
18Recurrent fungal infections (HP:0002841)3.71149756
19Hemoptysis (HP:0002105)3.66717890
20Recurrent skin infections (HP:0001581)3.64950304
21Recurrent gram-negative bacterial infections (HP:0005420)3.62438975
22Myositis (HP:0100614)3.58817322
23Elevated erythrocyte sedimentation rate (HP:0003565)3.45483749
24Abnormality of the prostate (HP:0008775)3.45276151
25Increased cerebral lipofuscin (HP:0011813)3.40278250
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.39737308
27Recurrent viral infections (HP:0004429)3.34829082
28Colitis (HP:0002583)3.27802416
29Gastrointestinal stroma tumor (HP:0100723)3.27710044
30Panhypogammaglobulinemia (HP:0003139)3.25241472
31Urticaria (HP:0001025)3.24304184
32Orchitis (HP:0100796)3.24096101
33Chest pain (HP:0100749)3.21802201
34Gastrointestinal infarctions (HP:0005244)3.18660400
35Optic neuritis (HP:0100653)3.18031254
36Retrobulbar optic neuritis (HP:0100654)3.18031254
37Vacuolated lymphocytes (HP:0001922)3.09741295
38Increased neuronal autofluorescent lipopigment (HP:0002074)3.04909223
39Restrictive lung disease (HP:0002091)3.01214135
40Recurrent bronchitis (HP:0002837)2.99577734
41Cellulitis (HP:0100658)2.97703174
42Recurrent sinusitis (HP:0011108)2.92954296
43Abnormality of the pleura (HP:0002103)2.92295923
44Inflammation of the large intestine (HP:0002037)2.88177215
45Encephalitis (HP:0002383)2.87696065
46Gastrointestinal inflammation (HP:0004386)2.73708059
47Increased IgE level (HP:0003212)2.70772899
48Stomatitis (HP:0010280)2.69888839
49Spontaneous hematomas (HP:0007420)2.69753519
50Skin rash (HP:0000988)2.68325813
51Chronic diarrhea (HP:0002028)2.65804758
52Gangrene (HP:0100758)2.63859636
53Dysostosis multiplex (HP:0000943)2.62253074
54Osteomyelitis (HP:0002754)2.61693263
55Increased IgM level (HP:0003496)2.57386618
56Loss of speech (HP:0002371)2.56402163
57Gingivitis (HP:0000230)2.55870079
58Pulmonary embolism (HP:0002204)2.52289143
59Glomerulonephritis (HP:0000099)2.51530096
60Epistaxis (HP:0000421)2.49760698
61Pulmonary fibrosis (HP:0002206)2.47762868
62Abnormality of complement system (HP:0005339)2.47277380
63Purpura (HP:0000979)2.46273677
64Amyloidosis (HP:0011034)2.46002596
65Abnormality of T cell number (HP:0011839)2.44575429
66Autoimmune thrombocytopenia (HP:0001973)2.44520494
67T lymphocytopenia (HP:0005403)2.42401554
68Emphysema (HP:0002097)2.39340719
69Chronic otitis media (HP:0000389)2.39302863
70Recurrent pneumonia (HP:0006532)2.35122974
71Keratoconjunctivitis sicca (HP:0001097)2.34728260
72Petechiae (HP:0000967)2.34132340
73Pustule (HP:0200039)2.32301169
74Acrocyanosis (HP:0001063)2.31897725
75Lymphopenia (HP:0001888)2.31884154
76Arterial thrombosis (HP:0004420)2.30848772
77Abnormality of T cells (HP:0002843)2.29524435
78Hypergammaglobulinemia (HP:0010702)2.28712612
79Polyneuropathy (HP:0001271)2.26371143
80IgM deficiency (HP:0002850)2.26165094
81Glomerulopathy (HP:0100820)2.25813293
82Abnormality of cells of the lymphoid lineage (HP:0012140)2.22818832
83Recurrent lower respiratory tract infections (HP:0002783)2.20231070
84Amaurosis fugax (HP:0100576)2.20181743
85Gingival bleeding (HP:0000225)2.20142302
86Xerostomia (HP:0000217)2.18684156
87Skin ulcer (HP:0200042)2.18545097
88Hypertensive crisis (HP:0100735)2.17092772
89Keratoconjunctivitis (HP:0001096)2.16169739
90Abnormality of B cell number (HP:0010975)2.15916135
91Abnormality of T cell physiology (HP:0011840)2.15219662
92Leukocytosis (HP:0001974)2.14659555
93Nephritis (HP:0000123)2.13169069
94Papilloma (HP:0012740)2.12261433
95Verrucae (HP:0200043)2.12261433
96Arthralgia (HP:0002829)2.10857583
97Malnutrition (HP:0004395)2.10255342
98Premature loss of primary teeth (HP:0006323)2.08788116
99Interstitial pulmonary disease (HP:0006530)2.08433163
100Complement deficiency (HP:0004431)2.07637067

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.34765223
2MAP4K14.06679866
3BLK4.02466770
4TYK23.25482934
5MAP3K142.95727691
6BMPR22.87222195
7ERN12.61786056
8CSF1R2.60854724
9KIT2.53833677
10JAK32.34136455
11SYK2.29678580
12MAP3K132.24922255
13FES2.14331472
14TBK12.11985572
15BTK2.02278458
16PRPF4B2.01133949
17IRAK41.99868273
18CSK1.96597318
19IKBKE1.92254078
20CDK191.84203718
21TXK1.84000762
22IKBKB1.83832713
23JAK11.82136713
24LYN1.74403420
25ZAP701.68336396
26TAOK31.65153396
27MATK1.53967695
28TEC1.47273985
29ITK1.41547821
30HCK1.37103594
31MAP2K31.31494105
32LCK1.28331975
33GRK71.27823383
34FGR1.26483635
35JAK21.18905950
36GRK61.15964496
37TNK21.07661810
38PIK3CG1.03980494
39CDC42BPA1.02026001
40NME20.99681034
41MAP3K30.99623486
42TGFBR20.93577218
43SIK30.93240662
44TAOK20.83260758
45IRAK30.81218897
46PDK10.80618764
47PRKCQ0.80040098
48MAP3K110.79359745
49MAP3K120.78519802
50FGFR30.74655951
51MAP3K10.74441781
52FGFR40.73015683
53TLK10.70380249
54MARK30.68988227
55MAPK70.68690392
56TESK20.67913144
57KDR0.67835195
58PDPK10.64949304
59MAPK120.64393094
60RIPK10.64194721
61CHUK0.63835556
62SCYL20.58033404
63ABL10.56561056
64CDK60.56259110
65FYN0.55777260
66STK100.55229979
67IRAK10.53777678
68PIM10.53414755
69TRPM70.50338602
70MOS0.47070402
71ACVR1B0.46897231
72HIPK20.44792477
73NEK90.44687750
74MAPK110.42907381
75PRKCD0.42759697
76TAOK10.42288937
77LRRK20.41794059
78MAP3K50.41744267
79EGFR0.40483735
80MAPKAPK20.40480927
81EPHB10.39384998
82DDR20.38757042
83CDK40.37366485
84IGF1R0.36373094
85EPHA30.34997272
86MAPK40.34929211
87SIK20.32987328
88STK240.32224857
89SMG10.31773680
90YES10.29981845
91ADRBK20.29817791
92RPS6KL10.29617105
93RPS6KC10.29617105
94DAPK30.29565201
95OXSR10.29121376
96MAP2K60.27654572
97PIM20.25713024
98DAPK10.23528884
99INSR0.22500485
100IRAK20.22116125

Predicted pathways (KEGG)

RankGene SetZ-score
1* Asthma_Homo sapiens_hsa053105.28745639
2* Allograft rejection_Homo sapiens_hsa053304.86690997
3* Autoimmune thyroid disease_Homo sapiens_hsa053204.54323459
4* Graft-versus-host disease_Homo sapiens_hsa053324.48836104
5* Intestinal immune network for IgA production_Homo sapiens_hsa046724.10805266
6* Type I diabetes mellitus_Homo sapiens_hsa049403.78508840
7* Staphylococcus aureus infection_Homo sapiens_hsa051503.78433758
8* Leishmaniasis_Homo sapiens_hsa051403.19401282
9* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.97586300
10* Antigen processing and presentation_Homo sapiens_hsa046122.88411989
11* Viral myocarditis_Homo sapiens_hsa054162.78590197
12* Rheumatoid arthritis_Homo sapiens_hsa053232.32402052
13* Tuberculosis_Homo sapiens_hsa051521.97806288
14Primary immunodeficiency_Homo sapiens_hsa053401.87727401
15Hematopoietic cell lineage_Homo sapiens_hsa046401.83306665
16* Toxoplasmosis_Homo sapiens_hsa051451.78188080
17Osteoclast differentiation_Homo sapiens_hsa043801.60929744
18* Influenza A_Homo sapiens_hsa051641.58759755
19B cell receptor signaling pathway_Homo sapiens_hsa046621.56021737
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.47686751
21* Herpes simplex infection_Homo sapiens_hsa051681.47055544
22* Phagosome_Homo sapiens_hsa041451.46503677
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.38080151
24Other glycan degradation_Homo sapiens_hsa005111.35453715
25* Systemic lupus erythematosus_Homo sapiens_hsa053221.22267675
26Pertussis_Homo sapiens_hsa051331.15461925
27* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14259910
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06182938
29Lysosome_Homo sapiens_hsa041421.02098981
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94990756
31Measles_Homo sapiens_hsa051620.94101538
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91545749
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87367190
34Malaria_Homo sapiens_hsa051440.86147567
35Legionellosis_Homo sapiens_hsa051340.85960239
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85875717
37Chemokine signaling pathway_Homo sapiens_hsa040620.83953699
38African trypanosomiasis_Homo sapiens_hsa051430.76627612
39* Epstein-Barr virus infection_Homo sapiens_hsa051690.74894902
40TNF signaling pathway_Homo sapiens_hsa046680.72187853
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69585311
42Jak-STAT signaling pathway_Homo sapiens_hsa046300.69306737
43Salmonella infection_Homo sapiens_hsa051320.67166294
44T cell receptor signaling pathway_Homo sapiens_hsa046600.66649899
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65169694
46Glycosaminoglycan degradation_Homo sapiens_hsa005310.63880957
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60950555
48Hepatitis C_Homo sapiens_hsa051600.53589951
49Shigellosis_Homo sapiens_hsa051310.52506098
50Platelet activation_Homo sapiens_hsa046110.50431429
51* HTLV-I infection_Homo sapiens_hsa051660.47752928
52Hepatitis B_Homo sapiens_hsa051610.46702036
53Acute myeloid leukemia_Homo sapiens_hsa052210.44757022
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.44437265
55Apoptosis_Homo sapiens_hsa042100.43180054
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40112594
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39110822
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39079750
59Renin-angiotensin system_Homo sapiens_hsa046140.32084031
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31031792
61Complement and coagulation cascades_Homo sapiens_hsa046100.30013508
62Arachidonic acid metabolism_Homo sapiens_hsa005900.28367692
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27505783
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26886505
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.22873578
66Collecting duct acid secretion_Homo sapiens_hsa049660.20301822
67Viral carcinogenesis_Homo sapiens_hsa052030.18283611
68Amoebiasis_Homo sapiens_hsa051460.15568999
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14405178
70Prolactin signaling pathway_Homo sapiens_hsa049170.14090897
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13855497
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.11775845
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.11754985
74Endocytosis_Homo sapiens_hsa041440.11685129
75Pancreatic cancer_Homo sapiens_hsa052120.10649593
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.10384049
77Linoleic acid metabolism_Homo sapiens_hsa005910.09690593
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.08752706
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.06641067
80VEGF signaling pathway_Homo sapiens_hsa043700.05906780
81Sphingolipid metabolism_Homo sapiens_hsa006000.05713992
82Histidine metabolism_Homo sapiens_hsa003400.05373543
83Regulation of autophagy_Homo sapiens_hsa041400.05019465
84Non-small cell lung cancer_Homo sapiens_hsa052230.04275738
85Ether lipid metabolism_Homo sapiens_hsa005650.03843028
86PPAR signaling pathway_Homo sapiens_hsa033200.03193263
87Vitamin digestion and absorption_Homo sapiens_hsa049770.02304829
88Galactose metabolism_Homo sapiens_hsa000520.02012727
89Tryptophan metabolism_Homo sapiens_hsa003800.01754407
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.01549329
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.01541111
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.01135403
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.00820618
94Mineral absorption_Homo sapiens_hsa049780.00636758
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.00531660
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.00352833
97GnRH signaling pathway_Homo sapiens_hsa04912-0.0201813
98Prion diseases_Homo sapiens_hsa05020-0.0087341
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750-0.0059339
100HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0020910

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