HLA-DPA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1eosinophil chemotaxis (GO:0048245)6.37285895
2immunoglobulin mediated immune response (GO:0016064)6.03979470
3regulation of hypersensitivity (GO:0002883)5.93912487
4regulation of mononuclear cell migration (GO:0071675)5.79958600
5eosinophil migration (GO:0072677)5.70550786
6phagocytosis, engulfment (GO:0006911)5.58797881
7phagocytosis, recognition (GO:0006910)5.48236777
8regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.44872274
9regulation of macrophage chemotaxis (GO:0010758)5.37327792
10B cell mediated immunity (GO:0019724)5.03782848
11positive regulation of inflammatory response to antigenic stimulus (GO:0002863)5.00307613
12regulation of acute inflammatory response to antigenic stimulus (GO:0002864)4.79055526
13membrane invagination (GO:0010324)4.42977108
14interferon-gamma-mediated signaling pathway (GO:0060333)4.41817839
15positive regulation of cAMP-mediated signaling (GO:0043950)4.32243263
16positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.13767953
17positive regulation of toll-like receptor signaling pathway (GO:0034123)3.98384169
18response to interferon-beta (GO:0035456)3.95749988
19response to xenobiotic stimulus (GO:0009410)3.94421653
20cellular response to interferon-gamma (GO:0071346)3.76532194
21long term synaptic depression (GO:0060292)3.73513459
22negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.72290976
23glycosphingolipid catabolic process (GO:0046479)3.69756182
24regulation of meiosis I (GO:0060631)3.62634698
25antigen processing and presentation via MHC class Ib (GO:0002475)3.58947508
26microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.58253732
27regulation of inflammatory response to antigenic stimulus (GO:0002861)3.53900772
28regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.49000996
29antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.42131117
30response to interferon-gamma (GO:0034341)3.41235432
31regulation of cholesterol storage (GO:0010885)3.38658481
32regulation of antigen processing and presentation (GO:0002577)3.36946618
33negative regulation of meiosis (GO:0045835)3.36299405
34glycolipid catabolic process (GO:0019377)3.30932687
35cellular response to interferon-beta (GO:0035458)3.28588711
36platelet dense granule organization (GO:0060155)3.26676299
37protein localization to cilium (GO:0061512)3.26393748
38leukocyte mediated cytotoxicity (GO:0001909)3.22497280
39angiogenesis involved in wound healing (GO:0060055)3.21984305
40positive regulation of antigen processing and presentation (GO:0002579)3.16035015
41coenzyme catabolic process (GO:0009109)3.14251213
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.10444198
43ceramide catabolic process (GO:0046514)3.08772297
44inflammatory response to antigenic stimulus (GO:0002437)3.07975785
45sphingolipid catabolic process (GO:0030149)3.07266548
46attachment of spindle microtubules to kinetochore (GO:0008608)3.05211341
47positive thymic T cell selection (GO:0045059)3.03364358
48regulation of mitotic spindle checkpoint (GO:1903504)3.01782509
49regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.01782509
50positive regulation of interleukin-1 beta secretion (GO:0050718)2.99068389
51DNA deamination (GO:0045006)2.99041431
52neuronal action potential propagation (GO:0019227)2.99000586
53oligosaccharide catabolic process (GO:0009313)2.97514464
54intracellular pH reduction (GO:0051452)2.94174339
55positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.91543934
56positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.91543934
57positive regulation of mitotic sister chromatid separation (GO:1901970)2.91543934
58ubiquinone biosynthetic process (GO:0006744)2.89535909
59stress fiber assembly (GO:0043149)2.86614626
60primitive streak formation (GO:0090009)2.85787884
61regulation of cAMP-mediated signaling (GO:0043949)2.81594305
62negative regulation of calcium ion transport into cytosol (GO:0010523)2.81140399
63natural killer cell differentiation (GO:0001779)2.78847713
64positive regulation of interleukin-1 secretion (GO:0050716)2.77419193
65membrane lipid catabolic process (GO:0046466)2.77310210
66purine ribonucleotide transport (GO:0015868)2.74262673
67positive regulation of protein oligomerization (GO:0032461)2.73877717
68detection of external biotic stimulus (GO:0098581)2.71731651
69pH reduction (GO:0045851)2.69100997
70myeloid leukocyte mediated immunity (GO:0002444)2.68456951
71detection of bacterium (GO:0016045)2.67764951
72T cell costimulation (GO:0031295)2.66711291
73phosphatidylinositol acyl-chain remodeling (GO:0036149)2.66157033
74positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.63243373
75granulocyte activation (GO:0036230)2.63222529
76lymphocyte costimulation (GO:0031294)2.62461920
77adenine nucleotide transport (GO:0051503)2.62413693
78positive regulation of prostaglandin secretion (GO:0032308)2.61840041
79negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.61579156
80monocyte chemotaxis (GO:0002548)2.59488305
81regulation of interleukin-1 beta secretion (GO:0050706)2.58094248
82antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.55986807
83negative regulation of receptor-mediated endocytosis (GO:0048261)2.54561491
84positive regulation of natural killer cell differentiation (GO:0032825)2.54010403
85cellular component maintenance (GO:0043954)2.53189697
86negative regulation of complement activation (GO:0045916)2.52874096
87detection of other organism (GO:0098543)2.52334425
88cytidine deamination (GO:0009972)2.51724412
89cytidine metabolic process (GO:0046087)2.51724412
90cytidine catabolic process (GO:0006216)2.51724412
91melanin biosynthetic process (GO:0042438)2.50755430
92anterograde synaptic vesicle transport (GO:0048490)2.50434074
93response to dietary excess (GO:0002021)2.49947140
94positive regulation of neutrophil chemotaxis (GO:0090023)2.49149052
95positive regulation of neutrophil migration (GO:1902624)2.49149052
96regulation of cellular amino acid metabolic process (GO:0006521)2.48465976
97hepatocyte apoptotic process (GO:0097284)2.48183180
98microglial cell activation (GO:0001774)2.47343632
99secondary metabolite biosynthetic process (GO:0044550)2.47309337
100positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.45750685

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.05969935
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.59356018
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.14777643
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.13476806
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.21812777
6ZNF274_21170338_ChIP-Seq_K562_Hela3.17486175
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.80745067
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.79463019
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.74820905
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.64443776
11IRF1_19129219_ChIP-ChIP_H3396_Human2.56020416
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.47680341
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.24552479
14VDR_22108803_ChIP-Seq_LS180_Human2.11093032
15VDR_24787735_ChIP-Seq_THP-1_Human2.06438393
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.02219409
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.97412157
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77588674
19CIITA_25753668_ChIP-Seq_RAJI_Human1.73611700
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71917814
21HTT_18923047_ChIP-ChIP_STHdh_Human1.66410359
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64367549
23VDR_23849224_ChIP-Seq_CD4+_Human1.56901348
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.54522909
25PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.50908623
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47658081
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.47380825
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45873132
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.45864463
30P300_19829295_ChIP-Seq_ESCs_Human1.43973349
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41726675
32GATA3_26560356_Chip-Seq_TH2_Human1.38688118
33GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.38560976
34TP53_22573176_ChIP-Seq_HFKS_Human1.36714279
35SMRT_27268052_Chip-Seq_Bcells_Human1.36502085
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35053261
37ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34098530
38ER_23166858_ChIP-Seq_MCF-7_Human1.33058012
39GBX2_23144817_ChIP-Seq_PC3_Human1.30274021
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27771264
41KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27710208
42TFEB_21752829_ChIP-Seq_HELA_Human1.26960364
43FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26926326
44NANOG_19829295_ChIP-Seq_ESCs_Human1.26779432
45SOX2_19829295_ChIP-Seq_ESCs_Human1.26779432
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26433609
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.24780603
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.23962688
49FOXP3_21729870_ChIP-Seq_TREG_Human1.21526350
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20568316
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.20568316
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17069843
53FUS_26573619_Chip-Seq_HEK293_Human1.16611411
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16471325
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15641214
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14267595
57EWS_26573619_Chip-Seq_HEK293_Human1.13858326
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13774091
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13642928
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12568258
61REST_19997604_ChIP-ChIP_NEURONS_Mouse1.12498137
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12455885
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11340188
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10315168
65RBPJ_21746931_ChIP-Seq_IB4_Human1.08634868
66NCOR_22424771_ChIP-Seq_293T_Human1.07805719
67MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05484660
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.05076285
69GATA6_21074721_ChIP-Seq_CACO-2_Human1.03373880
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02480241
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02270523
72SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01599599
73SALL4_22934838_ChIP-ChIP_CD34+_Human1.01267371
74CRX_20693478_ChIP-Seq_RETINA_Mouse1.01076898
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00822489
76SPI1_23547873_ChIP-Seq_NB4_Human1.00659035
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.00160860
78CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99684746
79CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99224346
80FOXH1_21741376_ChIP-Seq_EPCs_Human0.97695043
81GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.97370121
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96857435
83ELK1_19687146_ChIP-ChIP_HELA_Human0.96746735
84YY1_22570637_ChIP-Seq_MALME-3M_Human0.96160680
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95626636
86YY1_21170310_ChIP-Seq_MESCs_Mouse0.95432162
87AR_20517297_ChIP-Seq_VCAP_Human0.94857039
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94047546
89SMAD4_21799915_ChIP-Seq_A2780_Human0.93837604
90CMYC_18555785_Chip-Seq_ESCs_Mouse0.93247628
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92741640
92STAT3_18555785_Chip-Seq_ESCs_Mouse0.90506217
93NANOG_20526341_ChIP-Seq_ESCs_Human0.90297985
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89276203
95PRDM14_20953172_ChIP-Seq_ESCs_Human0.88811542
96JUN_21703547_ChIP-Seq_K562_Human0.88142780
97TAF15_26573619_Chip-Seq_HEK293_Human0.88049872
98EGR1_19032775_ChIP-ChIP_M12_Human0.86420047
99STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.85604130
100P53_21459846_ChIP-Seq_SAOS-2_Human0.85065609

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation7.89828591
2MP0009840_abnormal_foam_cell5.94556254
3MP0003787_abnormal_imprinting3.84171738
4MP0000015_abnormal_ear_pigmentation3.65301101
5MP0005174_abnormal_tail_pigmentation2.79149044
6MP0002102_abnormal_ear_morphology2.76248394
7MP0005671_abnormal_response_to2.70615323
8MP0008877_abnormal_DNA_methylation2.68265913
9MP0001835_abnormal_antigen_presentation2.60844176
10MP0002090_abnormal_vision2.50418430
11MP0005360_urolithiasis2.41501801
12MP0002877_abnormal_melanocyte_morpholog2.41478207
13MP0002139_abnormal_hepatobiliary_system2.24794329
14MP0005075_abnormal_melanosome_morpholog2.15478401
15MP0005408_hypopigmentation2.10296282
16MP0000372_irregular_coat_pigmentation1.97997132
17MP0005058_abnormal_lysosome_morphology1.94442123
18MP0000371_diluted_coat_color1.88713744
19MP0000604_amyloidosis1.87083719
20MP0005387_immune_system_phenotype1.80033923
21MP0001790_abnormal_immune_system1.80033923
22MP0002277_abnormal_respiratory_mucosa1.79172545
23MP0002148_abnormal_hypersensitivity_rea1.65826262
24MP0003121_genomic_imprinting1.65392880
25MP0010386_abnormal_urinary_bladder1.63622058
26MP0002095_abnormal_skin_pigmentation1.63203421
27MP0009764_decreased_sensitivity_to1.60363789
28MP0002166_altered_tumor_susceptibility1.59539535
29MP0008057_abnormal_DNA_replication1.57159711
30MP0001324_abnormal_eye_pigmentation1.55158953
31MP0005167_abnormal_blood-brain_barrier1.53151477
32MP0009785_altered_susceptibility_to1.53037832
33MP0002009_preneoplasia1.52552450
34MP0003172_abnormal_lysosome_physiology1.46279254
35MP0009046_muscle_twitch1.45054351
36MP0003136_yellow_coat_color1.44401640
37MP0003806_abnormal_nucleotide_metabolis1.41244837
38MP0004270_analgesia1.40589538
39MP0003880_abnormal_central_pattern1.40288873
40MP0005365_abnormal_bile_salt1.37300579
41MP0002006_tumorigenesis1.30778424
42MP0003191_abnormal_cellular_cholesterol1.30688552
43MP0003315_abnormal_perineum_morphology1.27356862
44MP0005025_abnormal_response_to1.23678789
45MP0006276_abnormal_autonomic_nervous1.21813014
46MP0002452_abnormal_antigen_presenting1.20430549
47MP0003718_maternal_effect1.19029210
48MP0008875_abnormal_xenobiotic_pharmacok1.18305456
49MP0002638_abnormal_pupillary_reflex1.16574199
50MP0000647_abnormal_sebaceous_gland1.13340540
51MP0001800_abnormal_humoral_immune1.11718290
52MP0002419_abnormal_innate_immunity1.10192829
53MP0004742_abnormal_vestibular_system1.10125384
54MP0005000_abnormal_immune_tolerance1.04442646
55MP0005464_abnormal_platelet_physiology1.04047083
56MP0003448_altered_tumor_morphology1.03303782
57MP0006082_CNS_inflammation1.02697872
58MP0003195_calcinosis1.01587802
59MP0003300_gastrointestinal_ulcer1.01094035
60MP0005646_abnormal_pituitary_gland0.98843133
61MP0001186_pigmentation_phenotype0.97280570
62MP0002723_abnormal_immune_serum0.96757954
63MP0003646_muscle_fatigue0.94454379
64MP0001845_abnormal_inflammatory_respons0.90637343
65MP0001819_abnormal_immune_cell0.87866523
66MP0002420_abnormal_adaptive_immunity0.86989273
67MP0002272_abnormal_nervous_system0.86624334
68MP0002229_neurodegeneration0.86129375
69MP0000685_abnormal_immune_system0.84782604
70MP0003221_abnormal_cardiomyocyte_apopto0.84663146
71MP0008260_abnormal_autophagy0.82530535
72MP0005257_abnormal_intraocular_pressure0.80890453
73MP0003724_increased_susceptibility_to0.80674331
74MP0000343_altered_response_to0.78770854
75MP0005645_abnormal_hypothalamus_physiol0.76605063
76MP0005310_abnormal_salivary_gland0.76364576
77MP0000920_abnormal_myelination0.74994938
78MP0002067_abnormal_sensory_capabilities0.74033260
79MP0005423_abnormal_somatic_nervous0.73124902
80MP0002254_reproductive_system_inflammat0.71630315
81MP0005171_absent_coat_pigmentation0.70905753
82MP0005551_abnormal_eye_electrophysiolog0.68735887
83MP0001984_abnormal_olfaction0.68593328
84MP0002822_catalepsy0.63494941
85MP0001756_abnormal_urination0.62926160
86MP0003137_abnormal_impulse_conducting0.62335083
87MP0008469_abnormal_protein_level0.62205875
88MP0010094_abnormal_chromosome_stability0.61746489
89MP0002075_abnormal_coat/hair_pigmentati0.60148292
90MP0003186_abnormal_redox_activity0.60029896
91MP0005377_hearing/vestibular/ear_phenot0.59624937
92MP0003878_abnormal_ear_physiology0.59624937
93MP0001853_heart_inflammation0.59258250
94MP0002064_seizures0.59156968
95MP0008007_abnormal_cellular_replicative0.59095253
96MP0000716_abnormal_immune_system0.54980458
97MP0002734_abnormal_mechanical_nocicepti0.53246296
98MP0001970_abnormal_pain_threshold0.52226288
99MP0003690_abnormal_glial_cell0.51507100
100MP0003633_abnormal_nervous_system0.51470145

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)8.97814631
2Albinism (HP:0001022)5.14202961
3Glomerulonephritis (HP:0000099)4.79165804
4Abnormality of liposaccharide metabolism (HP:0010968)4.73997387
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.73997387
6Abnormality of glycolipid metabolism (HP:0010969)4.73997387
7Generalized hypopigmentation (HP:0007513)3.97364317
8Prostate neoplasm (HP:0100787)3.75570475
9Thick nail (HP:0001805)3.66386588
10Complement deficiency (HP:0004431)3.51983755
11Mutism (HP:0002300)3.49727415
12Premature loss of primary teeth (HP:0006323)3.46457681
13Iris hypopigmentation (HP:0007730)3.39904399
14Fetal akinesia sequence (HP:0001989)3.37242013
15Abnormality of the labia minora (HP:0012880)3.31722831
16Axonal loss (HP:0003447)3.19539583
17Hip dysplasia (HP:0001385)3.12122091
18Aplasia/Hypoplasia of the fovea (HP:0008060)3.06103031
19Hypoplasia of the fovea (HP:0007750)3.06103031
20Periodontitis (HP:0000704)3.04237007
21Ocular albinism (HP:0001107)3.03658364
22Methylmalonic aciduria (HP:0012120)3.02336965
23Large eyes (HP:0001090)3.00422655
24Abnormality of the prostate (HP:0008775)3.00233501
25Recurrent bacterial skin infections (HP:0005406)2.90832700
26Disinhibition (HP:0000734)2.84759414
27Fair hair (HP:0002286)2.84382251
28Generalized hypopigmentation of hair (HP:0011358)2.72958406
29Vacuolated lymphocytes (HP:0001922)2.68592480
30Polyphagia (HP:0002591)2.63000686
31Abnormality of the fovea (HP:0000493)2.59129243
32Cortical dysplasia (HP:0002539)2.56238369
33Increased hepatocellular lipid droplets (HP:0006565)2.54056750
34Esophageal neoplasm (HP:0100751)2.52774312
35Neoplasm of head and neck (HP:0012288)2.52774312
36Agnosia (HP:0010524)2.52627759
37Blue irides (HP:0000635)2.51589855
38Pustule (HP:0200039)2.49959968
39Dialeptic seizures (HP:0011146)2.49520087
40Renal Fanconi syndrome (HP:0001994)2.45747054
41Degeneration of anterior horn cells (HP:0002398)2.38601560
42Abnormality of the anterior horn cell (HP:0006802)2.38601560
43Failure to thrive in infancy (HP:0001531)2.37682485
44Spastic diplegia (HP:0001264)2.35615526
45Lipid accumulation in hepatocytes (HP:0006561)2.34398476
46Abnormality of macrophages (HP:0004311)2.33478870
47Tinnitus (HP:0000360)2.24995415
48Recurrent abscess formation (HP:0002722)2.24540748
49Abnormality of the basal ganglia (HP:0002134)2.22527576
50Ketosis (HP:0001946)2.22289242
51Abnormality of complement system (HP:0005339)2.18927775
52Aplasia/Hypoplasia of the macula (HP:0008059)2.17414243
53Mediastinal lymphadenopathy (HP:0100721)2.15238292
54Generalized tonic-clonic seizures (HP:0002069)2.14769579
55Inappropriate behavior (HP:0000719)2.13704208
56Focal seizures (HP:0007359)2.12614059
57Peripheral hypomyelination (HP:0007182)2.07830987
58Hyperventilation (HP:0002883)2.07813785
59Abolished electroretinogram (ERG) (HP:0000550)2.07161180
60Osteolytic defects of the phalanges of the hand (HP:0009771)2.04397024
61Osteolytic defects of the hand bones (HP:0009699)2.04397024
62Aplasia/Hypoplasia affecting the retina (HP:0008061)2.00536313
63Abnormal hair whorl (HP:0010721)2.00452122
64Acute necrotizing encephalopathy (HP:0006965)2.00166100
65Exertional dyspnea (HP:0002875)1.99275375
66Spinal muscular atrophy (HP:0007269)1.98674214
67Atonic seizures (HP:0010819)1.93730655
68Ridged nail (HP:0001807)1.92251681
69Decreased muscle mass (HP:0003199)1.91526590
70Retinal dysplasia (HP:0007973)1.88412289
71Methylmalonic acidemia (HP:0002912)1.87658461
72Reduced antithrombin III activity (HP:0001976)1.86162922
73Scanning speech (HP:0002168)1.85682842
74Nephritis (HP:0000123)1.85181322
75Ependymoma (HP:0002888)1.80920171
76Myokymia (HP:0002411)1.78936989
77Increased CSF lactate (HP:0002490)1.78908218
78Mitochondrial inheritance (HP:0001427)1.77833255
79Gingivitis (HP:0000230)1.74695719
80Progressive macrocephaly (HP:0004481)1.73107119
81Diaphragmatic weakness (HP:0009113)1.73027475
82Carpal bone hypoplasia (HP:0001498)1.72134078
83Retinal atrophy (HP:0001105)1.71094868
84Erythema (HP:0010783)1.70750470
85Paralysis (HP:0003470)1.70490334
86Pachygyria (HP:0001302)1.70022608
87Late onset (HP:0003584)1.69237216
88Selective tooth agenesis (HP:0001592)1.67740933
89IgA deficiency (HP:0002720)1.64738217
90Febrile seizures (HP:0002373)1.64451652
91Disproportionate short-trunk short stature (HP:0003521)1.64033461
92Zonular cataract (HP:0010920)1.62600386
93Diminished motivation (HP:0000745)1.60885838
94Apathy (HP:0000741)1.60877516
95Action tremor (HP:0002345)1.60230351
96Pulmonary fibrosis (HP:0002206)1.59400482
97Pulmonary infiltrates (HP:0002113)1.59068801
98Acute encephalopathy (HP:0006846)1.59045965
99Clitoromegaly (HP:0000057)1.58806414
100Ketoacidosis (HP:0001993)1.57628768

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM286.10533899
2DMPK4.72501306
3MAP4K23.97990340
4ZAK3.89937259
5PDK23.26370908
6STK162.40123044
7PBK2.31336509
8TXK2.30231514
9LATS22.23256977
10BLK1.87634809
11MKNK21.81745178
12CSNK1G31.81091346
13CSNK1G21.77700308
14MST41.67963399
15TLK11.66741477
16BUB11.59823042
17NUAK11.53722649
18TSSK61.51298918
19CSNK1A1L1.40710064
20RPS6KA51.34386468
21CSNK1G11.33034483
22ACVR1B1.28878501
23RPS6KA21.27345275
24MAP2K71.26894231
25MAP3K121.23083076
26CDK91.21366452
27CDK61.20678148
28MINK11.19598665
29ERBB31.14385776
30TTK1.12588850
31ADRBK21.07885135
32OXSR11.04877471
33MKNK11.04632250
34WNK31.02650696
35PINK10.96688183
36CDK30.94056678
37CAMKK20.92649902
38MATK0.91968910
39MAP3K50.89801189
40SIK30.88468728
41NEK20.87318773
42BCR0.87125531
43PLK30.86862890
44IKBKB0.85276715
45SRPK10.84665192
46CAMK2A0.80732185
47MARK30.77675381
48GRK10.77593470
49CSF1R0.75464755
50CDK190.73323690
51VRK10.68136168
52DYRK30.68045701
53PLK10.66857407
54FRK0.64984686
55PAK10.61719523
56DYRK20.61002733
57EGFR0.60837092
58TYK20.60413184
59BCKDK0.59472757
60ATR0.59256637
61PRKCG0.58513865
62SYK0.57061996
63ABL20.56408247
64ABL10.53929134
65BMPR20.53647622
66CSNK1D0.53040437
67CHEK20.52532009
68CSNK2A10.51637587
69PRKG10.50035230
70LYN0.49599558
71FYN0.47001767
72PRKCA0.43114896
73RPS6KA60.42741305
74CDK180.42001549
75IKBKE0.41781644
76CSNK1A10.41304686
77PRKACA0.41243169
78MAPKAPK30.40125387
79FGR0.39986050
80RPS6KC10.39898498
81RPS6KL10.39898498
82ALK0.39441924
83DAPK10.39172898
84IGF1R0.39045917
85MAP4K10.38676221
86PRKCE0.38285278
87BRD40.37284037
88DYRK1A0.36831435
89TNK20.36238854
90RPS6KA10.35726448
91STK40.35298284
92PRKACB0.34703129
93HCK0.33881948
94JAK30.33587175
95CDK150.33113751
96IRAK30.32897873
97KIT0.32794486
98CDK140.32214059
99LCK0.31330653
100NEK60.30395488

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051505.08103937
2Asthma_Homo sapiens_hsa053104.31056325
3Allograft rejection_Homo sapiens_hsa053303.93782493
4Autoimmune thyroid disease_Homo sapiens_hsa053203.85337649
5Graft-versus-host disease_Homo sapiens_hsa053323.74155478
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.27145059
7Type I diabetes mellitus_Homo sapiens_hsa049403.26403227
8Antigen processing and presentation_Homo sapiens_hsa046123.03282666
9Rheumatoid arthritis_Homo sapiens_hsa053232.79057176
10Proteasome_Homo sapiens_hsa030502.52094684
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.28159582
12Systemic lupus erythematosus_Homo sapiens_hsa053222.23173956
13Viral myocarditis_Homo sapiens_hsa054162.22654889
14Lysosome_Homo sapiens_hsa041421.98083477
15Leishmaniasis_Homo sapiens_hsa051401.97598548
16Phagosome_Homo sapiens_hsa041451.96815667
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85497137
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70511884
19Oxidative phosphorylation_Homo sapiens_hsa001901.45499702
20Collecting duct acid secretion_Homo sapiens_hsa049661.42286907
21Tuberculosis_Homo sapiens_hsa051521.40223354
22Fatty acid elongation_Homo sapiens_hsa000621.31001855
23Pertussis_Homo sapiens_hsa051331.17394957
24Nitrogen metabolism_Homo sapiens_hsa009101.13536836
25Complement and coagulation cascades_Homo sapiens_hsa046101.09233036
26Protein export_Homo sapiens_hsa030601.08708808
27Parkinsons disease_Homo sapiens_hsa050121.06401952
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.05135878
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04411070
30SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96127649
31Hematopoietic cell lineage_Homo sapiens_hsa046400.94092283
32Regulation of autophagy_Homo sapiens_hsa041400.88943774
33Chemokine signaling pathway_Homo sapiens_hsa040620.87693470
34Steroid biosynthesis_Homo sapiens_hsa001000.86367158
35Glycosaminoglycan degradation_Homo sapiens_hsa005310.85831158
36Linoleic acid metabolism_Homo sapiens_hsa005910.85597171
37Toxoplasmosis_Homo sapiens_hsa051450.85330722
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84602035
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84404664
40Arginine and proline metabolism_Homo sapiens_hsa003300.82230503
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81501644
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79645542
43beta-Alanine metabolism_Homo sapiens_hsa004100.76699410
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74841913
45Propanoate metabolism_Homo sapiens_hsa006400.74546202
46Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74385901
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71156557
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70759362
49Fructose and mannose metabolism_Homo sapiens_hsa000510.69525329
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68736196
51Nicotine addiction_Homo sapiens_hsa050330.67423879
52Synaptic vesicle cycle_Homo sapiens_hsa047210.67307513
53Osteoclast differentiation_Homo sapiens_hsa043800.65271047
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63928452
55Sulfur relay system_Homo sapiens_hsa041220.61304472
56Ether lipid metabolism_Homo sapiens_hsa005650.60133571
57Herpes simplex infection_Homo sapiens_hsa051680.59037008
58Prion diseases_Homo sapiens_hsa050200.57398940
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56970398
60Legionellosis_Homo sapiens_hsa051340.56678553
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52713938
62Pentose phosphate pathway_Homo sapiens_hsa000300.51289055
63Glutathione metabolism_Homo sapiens_hsa004800.50433531
64Mineral absorption_Homo sapiens_hsa049780.49055941
65Histidine metabolism_Homo sapiens_hsa003400.48667743
66Vibrio cholerae infection_Homo sapiens_hsa051100.45392068
67Influenza A_Homo sapiens_hsa051640.44708297
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44158488
69Huntingtons disease_Homo sapiens_hsa050160.43651815
70Alzheimers disease_Homo sapiens_hsa050100.43451358
71Tryptophan metabolism_Homo sapiens_hsa003800.41507289
72Galactose metabolism_Homo sapiens_hsa000520.41420258
73Basal transcription factors_Homo sapiens_hsa030220.40881002
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40646211
75Selenocompound metabolism_Homo sapiens_hsa004500.40136554
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39800929
77Epstein-Barr virus infection_Homo sapiens_hsa051690.38881716
78GABAergic synapse_Homo sapiens_hsa047270.38379646
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.36858663
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33960133
81Arachidonic acid metabolism_Homo sapiens_hsa005900.33814396
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31032014
83Phototransduction_Homo sapiens_hsa047440.30780058
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27953482
85Arginine biosynthesis_Homo sapiens_hsa002200.27946119
86Cardiac muscle contraction_Homo sapiens_hsa042600.26265035
87Morphine addiction_Homo sapiens_hsa050320.26158653
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24781806
89Other glycan degradation_Homo sapiens_hsa005110.24372682
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22752135
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22723414
92Carbon metabolism_Homo sapiens_hsa012000.21468996
93Taste transduction_Homo sapiens_hsa047420.21277635
94Sulfur metabolism_Homo sapiens_hsa009200.20073972
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18620721
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18499820
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18405523
98Olfactory transduction_Homo sapiens_hsa047400.17303103
99Shigellosis_Homo sapiens_hsa051310.16863004
100HTLV-I infection_Homo sapiens_hsa051660.15330111

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