HLA-DPB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)6.69671351
2antigen processing and presentation of endogenous antigen (GO:0019883)5.30148782
3B cell mediated immunity (GO:0019724)5.24233970
4positive regulation of gamma-delta T cell activation (GO:0046645)5.00358341
5* interferon-gamma-mediated signaling pathway (GO:0060333)4.98092437
6regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.95969268
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.79383875
8regulation of antigen processing and presentation (GO:0002577)4.73260113
9detection of bacterium (GO:0016045)4.66437895
10regulation of dendritic cell antigen processing and presentation (GO:0002604)4.58522116
11detection of other organism (GO:0098543)4.56823582
12positive regulation of antigen processing and presentation (GO:0002579)4.56456107
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.55715683
14neutrophil activation involved in immune response (GO:0002283)4.51777925
15positive thymic T cell selection (GO:0045059)4.35225198
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.32742157
17regulation of B cell receptor signaling pathway (GO:0050855)4.31395483
18negative regulation of cell killing (GO:0031342)4.20588520
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.20588520
20positive regulation by symbiont of host defense response (GO:0052509)4.17425688
21modulation by symbiont of host defense response (GO:0052031)4.17425688
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.17425688
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.17425688
24positive regulation by organism of defense response of other organism involved in symbiotic interact4.17425688
25modulation by symbiont of host immune response (GO:0052553)4.17425688
26T-helper 1 type immune response (GO:0042088)4.14883809
27response to peptidoglycan (GO:0032494)4.08072066
28macrophage activation involved in immune response (GO:0002281)4.01544786
29* cellular response to interferon-gamma (GO:0071346)3.91329187
30B cell receptor signaling pathway (GO:0050853)3.77637529
31negative regulation of interleukin-12 production (GO:0032695)3.76578281
32detection of external biotic stimulus (GO:0098581)3.69029985
33positive regulation of type 2 immune response (GO:0002830)3.68754292
34* T cell costimulation (GO:0031295)3.65145136
35type I interferon signaling pathway (GO:0060337)3.64121392
36cellular response to type I interferon (GO:0071357)3.64121392
37response to type I interferon (GO:0034340)3.61428768
38positive regulation of mast cell activation (GO:0033005)3.60817896
39* lymphocyte costimulation (GO:0031294)3.59734952
40regulation of gamma-delta T cell activation (GO:0046643)3.57597604
41regulation of interferon-beta biosynthetic process (GO:0045357)3.55844823
42* response to interferon-gamma (GO:0034341)3.54412824
43positive regulation of B cell differentiation (GO:0045579)3.52947447
44positive regulation of mast cell activation involved in immune response (GO:0033008)3.51128383
45positive regulation of mast cell degranulation (GO:0043306)3.51128383
46defense response to protozoan (GO:0042832)3.51073541
47regulation of mast cell degranulation (GO:0043304)3.41896118
48positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.40851155
49response to protozoan (GO:0001562)3.28819047
50positive T cell selection (GO:0043368)3.27517353
51myeloid cell activation involved in immune response (GO:0002275)3.26357030
52myeloid dendritic cell activation (GO:0001773)3.23097810
53microglial cell activation (GO:0001774)3.23084566
54detection of biotic stimulus (GO:0009595)3.22938084
55regulation of mast cell activation (GO:0033003)3.20994417
56negative thymic T cell selection (GO:0045060)3.20308886
57negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.16410996
58regulation of T cell tolerance induction (GO:0002664)3.16128359
59positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.16082070
60regulation of mast cell activation involved in immune response (GO:0033006)3.15730832
61regulation of alpha-beta T cell proliferation (GO:0046640)3.12534908
62regulation of T-helper 1 cell differentiation (GO:0045625)3.09957412
63adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.08710076
64regulation of B cell differentiation (GO:0045577)3.08457128
65myeloid dendritic cell differentiation (GO:0043011)3.07247641
66regulation of hypersensitivity (GO:0002883)3.06350931
67production of molecular mediator of immune response (GO:0002440)3.06289297
68regulation of interferon-alpha production (GO:0032647)3.04487975
69NIK/NF-kappaB signaling (GO:0038061)3.04122032
70positive regulation of interferon-alpha production (GO:0032727)3.03536096
71response to host immune response (GO:0052572)3.01004314
72response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.01004314
73regulation of gamma-delta T cell differentiation (GO:0045586)3.00238980
74negative T cell selection (GO:0043383)2.98492792
75germinal center formation (GO:0002467)2.97881026
76regulation of tolerance induction (GO:0002643)2.97611678
77T cell selection (GO:0045058)2.96550873
78* antigen receptor-mediated signaling pathway (GO:0050851)2.94109376
79positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.94051461
80T cell migration (GO:0072678)2.93672069
81response to muramyl dipeptide (GO:0032495)2.91744471
82neutrophil activation (GO:0042119)2.90374281
83thymic T cell selection (GO:0045061)2.89935085
84mature B cell differentiation involved in immune response (GO:0002313)2.89360021
85antigen processing and presentation via MHC class Ib (GO:0002475)2.88145929
86regulation of myeloid leukocyte mediated immunity (GO:0002886)2.88137276
87granulocyte activation (GO:0036230)2.87489841
88detection of molecule of bacterial origin (GO:0032490)2.86780589
89positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.86735490
90lipopolysaccharide-mediated signaling pathway (GO:0031663)2.86229176
91Arp2/3 complex-mediated actin nucleation (GO:0034314)2.84728971
92regulation of inflammatory response to antigenic stimulus (GO:0002861)2.83636520
93positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.83603798
94positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.81593233
95respiratory burst (GO:0045730)2.81492127
96macrophage activation (GO:0042116)2.81220128
97regulation of leukocyte degranulation (GO:0043300)2.79982918
98regulation of type 2 immune response (GO:0002828)2.78759251
99adaptive immune response (GO:0002250)2.76690920
100cellular extravasation (GO:0045123)2.75721959

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.61088915
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.99419079
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.83294656
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.02753822
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.52757512
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.42820540
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.16387135
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.16124924
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.15933908
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.08969482
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.86533836
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65159592
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.55897914
14SPI1_23547873_ChIP-Seq_NB4_Human2.52206587
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.44941150
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.43660101
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.42483132
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.38375118
19VDR_24763502_ChIP-Seq_THP-1_Human2.38072507
20SCL_19346495_ChIP-Seq_HPC-7_Human2.29794447
21MYB_26560356_Chip-Seq_TH2_Human2.27293201
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26385477
23VDR_21846776_ChIP-Seq_THP-1_Human2.25237132
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.23186416
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21228306
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.20518732
27RUNX_20019798_ChIP-Seq_JUKART_Human2.16207134
28SPI1_23127762_ChIP-Seq_K562_Human2.09362805
29MYC_22102868_ChIP-Seq_BL_Human2.03597191
30MAF_26560356_Chip-Seq_TH1_Human1.98036665
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95441955
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86591110
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.86391892
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.86059065
35MYB_26560356_Chip-Seq_TH1_Human1.84456380
36VDR_24787735_ChIP-Seq_THP-1_Human1.77138941
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.74335928
38UTX_26944678_Chip-Seq_JUKART_Human1.67052475
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.62000788
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.60108453
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.56721197
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55504248
43GATA3_27048872_Chip-Seq_THYMUS_Human1.55052040
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53111405
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51655810
46CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47775798
47GATA1_22025678_ChIP-Seq_K562_Human1.43259500
48GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.36334254
49* CIITA_25753668_ChIP-Seq_RAJI_Human1.36146352
50MAF_26560356_Chip-Seq_TH2_Human1.35754459
51GATA3_26560356_Chip-Seq_TH2_Human1.34225262
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29757218
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28928892
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27880845
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27342782
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25999187
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.25110495
58PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24771016
59BCL6_27268052_Chip-Seq_Bcells_Human1.23389176
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23138471
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21437792
62TCF7_22412390_ChIP-Seq_EML_Mouse1.21398346
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.20859099
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18642471
65SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17653551
66LXR_22292898_ChIP-Seq_THP-1_Human1.16703439
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15964267
68STAT1_20625510_ChIP-Seq_HELA_Human1.14002288
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13723860
70PU_27001747_Chip-Seq_BMDM_Mouse1.13148546
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12412488
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11165924
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10455508
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08004030
75BCOR_27268052_Chip-Seq_Bcells_Human1.06367383
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05882637
77PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05214028
78ELF1_20517297_ChIP-Seq_JURKAT_Human0.98845136
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95201501
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95109767
81KDM2B_26808549_Chip-Seq_DND41_Human0.95081762
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95003976
83GATA1_19941826_ChIP-Seq_K562_Human0.93995249
84ELK3_25401928_ChIP-Seq_HUVEC_Human0.91292036
85SPI1_20517297_ChIP-Seq_HL60_Human0.90716269
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90603074
87GATA2_21666600_ChIP-Seq_HMVEC_Human0.89648625
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89042945
89GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87463958
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86697489
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86471451
92EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86204246
93SMAD_19615063_ChIP-ChIP_OVARY_Human0.83134628
94P300_27268052_Chip-Seq_Bcells_Human0.82762335
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81267541
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78208273
97PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76161963
98SMRT_27268052_Chip-Seq_Bcells_Human0.74267456
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74245443
100CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72430730

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.90962515
2MP0005671_abnormal_response_to3.75299521
3MP0003303_peritoneal_inflammation3.63081056
4MP0003724_increased_susceptibility_to3.43578611
5MP0003436_decreased_susceptibility_to3.32220156
6MP0005387_immune_system_phenotype3.26442638
7MP0001790_abnormal_immune_system3.26442638
8MP0001800_abnormal_humoral_immune3.19942427
9MP0000685_abnormal_immune_system3.17610622
10MP0002148_abnormal_hypersensitivity_rea3.05947526
11MP0005000_abnormal_immune_tolerance3.05564369
12MP0009785_altered_susceptibility_to3.01854137
13MP0005025_abnormal_response_to2.82822148
14MP0002419_abnormal_innate_immunity2.81201082
15MP0002452_abnormal_antigen_presenting2.80883049
16MP0006082_CNS_inflammation2.72117708
17MP0002723_abnormal_immune_serum2.68569138
18MP0002420_abnormal_adaptive_immunity2.46661335
19MP0001819_abnormal_immune_cell2.45913973
20MP0005058_abnormal_lysosome_morphology2.23976048
21MP0010155_abnormal_intestine_physiology2.23705814
22MP0005464_abnormal_platelet_physiology2.01268293
23MP0003300_gastrointestinal_ulcer1.98194197
24MP0003172_abnormal_lysosome_physiology1.94520553
25MP0002138_abnormal_hepatobiliary_system1.91612228
26MP0001845_abnormal_inflammatory_respons1.90151093
27MP0000716_abnormal_immune_system1.87015832
28MP0003763_abnormal_thymus_physiology1.79567644
29MP0002398_abnormal_bone_marrow1.78975474
30MP0001533_abnormal_skeleton_physiology1.77621331
31MP0002405_respiratory_system_inflammati1.76207823
32MP0009764_decreased_sensitivity_to1.72145864
33MP0003191_abnormal_cellular_cholesterol1.71312592
34MP0003075_altered_response_to1.70002019
35MP0009333_abnormal_splenocyte_physiolog1.66990792
36MP0003183_abnormal_peptide_metabolism1.62357632
37MP0004947_skin_inflammation1.62212644
38MP0003806_abnormal_nucleotide_metabolis1.61987192
39MP0002166_altered_tumor_susceptibility1.61060153
40MP0008469_abnormal_protein_level1.59434544
41MP0001853_heart_inflammation1.53802883
42MP0000689_abnormal_spleen_morphology1.50599621
43MP0002429_abnormal_blood_cell1.47344482
44MP0005166_decreased_susceptibility_to1.46018007
45MP0002139_abnormal_hepatobiliary_system1.44043835
46MP0009840_abnormal_foam_cell1.42829094
47MP0009278_abnormal_bone_marrow1.40581032
48MP0003866_abnormal_defecation1.39157682
49MP0001545_abnormal_hematopoietic_system1.39075515
50MP0005397_hematopoietic_system_phenotyp1.39075515
51MP0005310_abnormal_salivary_gland1.38950101
52MP0000465_gastrointestinal_hemorrhage1.38142540
53MP0002722_abnormal_immune_system1.34257982
54MP0000343_altered_response_to1.33767690
55MP0005451_abnormal_body_composition1.32601421
56MP0001873_stomach_inflammation1.30491369
57MP0002998_abnormal_bone_remodeling1.29629957
58MP0000858_altered_metastatic_potential1.20526669
59MP0000604_amyloidosis1.19011869
60MP0002006_tumorigenesis1.09516557
61MP0008004_abnormal_stomach_pH1.08507599
62MP0004510_myositis1.02311353
63MP0001663_abnormal_digestive_system0.98758329
64MP0003448_altered_tumor_morphology0.96094368
65MP0002396_abnormal_hematopoietic_system0.92358841
66MP0009763_increased_sensitivity_to0.92241347
67MP0003828_pulmonary_edema0.92120286
68MP0000703_abnormal_thymus_morphology0.89968432
69MP0008260_abnormal_autophagy0.86746528
70MP0000249_abnormal_blood_vessel0.84516988
71MP0003690_abnormal_glial_cell0.82315509
72MP0005075_abnormal_melanosome_morpholog0.81372834
73MP0001851_eye_inflammation0.81273674
74MP0004883_abnormal_blood_vessel0.78763441
75MP0005165_increased_susceptibility_to0.78553005
76MP0002933_joint_inflammation0.78149790
77MP0000490_abnormal_crypts_of0.76577848
78MP0005167_abnormal_blood-brain_barrier0.71656945
79MP0002132_abnormal_respiratory_system0.70981690
80MP0005390_skeleton_phenotype0.70844003
81MP0005164_abnormal_response_to0.67885852
82MP0009765_abnormal_xenobiotic_induced0.65237140
83MP0002136_abnormal_kidney_physiology0.65085603
84MP0000015_abnormal_ear_pigmentation0.63818599
85MP0005365_abnormal_bile_salt0.62626105
86MP0009643_abnormal_urine_homeostasis0.61475691
87MP0003795_abnormal_bone_structure0.60479745
88MP0003045_fibrosis0.60302577
89MP0004808_abnormal_hematopoietic_stem0.59868884
90MP0000920_abnormal_myelination0.59661080
91MP0005319_abnormal_enzyme/_coenzyme0.58606666
92MP0005584_abnormal_enzyme/coenzyme_acti0.58517415
93MP0005381_digestive/alimentary_phenotyp0.57190557
94MP0008874_decreased_physiological_sensi0.55406024
95MP0005360_urolithiasis0.54979412
96MP0005535_abnormal_body_temperature0.53486828
97MP0000609_abnormal_liver_physiology0.53355433
98MP0002277_abnormal_respiratory_mucosa0.51879282
99MP0003091_abnormal_cell_migration0.51014233
100MP0002019_abnormal_tumor_incidence0.49485725

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.98028909
2Recurrent bacterial skin infections (HP:0005406)4.95624228
3Recurrent abscess formation (HP:0002722)4.83247860
4Abnormality of macrophages (HP:0004311)4.61126754
5Systemic lupus erythematosus (HP:0002725)4.45075501
6Mediastinal lymphadenopathy (HP:0100721)4.34863392
7Agammaglobulinemia (HP:0004432)4.26374344
8Abnormality of liposaccharide metabolism (HP:0010968)4.16496739
9Abnormality of glycosphingolipid metabolism (HP:0004343)4.16496739
10Abnormality of glycolipid metabolism (HP:0010969)4.16496739
11* Meningitis (HP:0001287)4.15908240
12Myositis (HP:0100614)3.82424579
13Recurrent fungal infections (HP:0002841)3.82067568
14Elevated erythrocyte sedimentation rate (HP:0003565)3.76706002
15Recurrent gram-negative bacterial infections (HP:0005420)3.72187235
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.71296661
17* Vasculitis (HP:0002633)3.65218070
18Recurrent cutaneous fungal infections (HP:0011370)3.61202816
19Chronic mucocutaneous candidiasis (HP:0002728)3.61202816
20Recurrent skin infections (HP:0001581)3.57810322
21Orchitis (HP:0100796)3.51844087
22Gastrointestinal stroma tumor (HP:0100723)3.48377272
23Panhypogammaglobulinemia (HP:0003139)3.44770137
24Optic neuritis (HP:0100653)3.43910345
25Retrobulbar optic neuritis (HP:0100654)3.43910345
26Urticaria (HP:0001025)3.41231100
27Recurrent viral infections (HP:0004429)3.40335292
28Increased cerebral lipofuscin (HP:0011813)3.38974571
29* Obstructive lung disease (HP:0006536)3.35363012
30* Chronic obstructive pulmonary disease (HP:0006510)3.35363012
31Colitis (HP:0002583)3.26064659
32Gastrointestinal infarctions (HP:0005244)3.20623401
33Cellulitis (HP:0100658)3.16588612
34* Pulmonary infiltrates (HP:0002113)3.13582278
35Vacuolated lymphocytes (HP:0001922)3.11798745
36Encephalitis (HP:0002383)3.05627506
37Stomatitis (HP:0010280)3.00591655
38Recurrent bronchitis (HP:0002837)2.99006640
39Increased neuronal autofluorescent lipopigment (HP:0002074)2.97989803
40Inflammation of the large intestine (HP:0002037)2.95382976
41Recurrent sinusitis (HP:0011108)2.95331947
42Increased IgE level (HP:0003212)2.89705737
43Spontaneous hematomas (HP:0007420)2.87420426
44Dysostosis multiplex (HP:0000943)2.86463443
45Increased IgM level (HP:0003496)2.84997825
46Autoimmune thrombocytopenia (HP:0001973)2.84969938
47Gastrointestinal inflammation (HP:0004386)2.79650105
48* Hemoptysis (HP:0002105)2.75211490
49Petechiae (HP:0000967)2.71242629
50Purpura (HP:0000979)2.68760616
51Chronic diarrhea (HP:0002028)2.68023632
52Loss of speech (HP:0002371)2.67511225
53Osteomyelitis (HP:0002754)2.63557758
54Abnormality of T cell number (HP:0011839)2.60814199
55T lymphocytopenia (HP:0005403)2.56190221
56Gingivitis (HP:0000230)2.54165345
57Pustule (HP:0200039)2.53664240
58Lymphopenia (HP:0001888)2.52320365
59Keratoconjunctivitis sicca (HP:0001097)2.51214584
60Abnormality of T cells (HP:0002843)2.50796069
61IgM deficiency (HP:0002850)2.49923393
62Glomerulonephritis (HP:0000099)2.49056549
63Recurrent pneumonia (HP:0006532)2.46971176
64* Restrictive lung disease (HP:0002091)2.45268684
65Amyloidosis (HP:0011034)2.44682970
66Abnormality of B cell number (HP:0010975)2.44537834
67Abnormality of cells of the lymphoid lineage (HP:0012140)2.42318921
68Hypergammaglobulinemia (HP:0010702)2.41620805
69Abnormality of T cell physiology (HP:0011840)2.37072327
70Emphysema (HP:0002097)2.36663086
71Recurrent lower respiratory tract infections (HP:0002783)2.34373619
72* Abnormality of the pleura (HP:0002103)2.34224580
73Chronic otitis media (HP:0000389)2.32693487
74Keratoconjunctivitis (HP:0001096)2.32575976
75Disinhibition (HP:0000734)2.31603254
76* Chest pain (HP:0100749)2.30902884
77Hypertensive crisis (HP:0100735)2.30255755
78Leukocytosis (HP:0001974)2.28457653
79Xerostomia (HP:0000217)2.24694414
80Arterial thrombosis (HP:0004420)2.24665315
81* Skin rash (HP:0000988)2.22946304
82Gingival bleeding (HP:0000225)2.20055421
83Papilloma (HP:0012740)2.19581589
84Verrucae (HP:0200043)2.19581589
85Acrocyanosis (HP:0001063)2.19304597
86Abnormality of complement system (HP:0005339)2.19052112
87Granulocytopenia (HP:0001913)2.18981625
88IgG deficiency (HP:0004315)2.18584369
89Prolonged bleeding time (HP:0003010)2.16627255
90Autoimmune hemolytic anemia (HP:0001890)2.14448752
91* Epistaxis (HP:0000421)2.13224252
92Sepsis (HP:0100806)2.11250655
93Abnormality of polysaccharide metabolism (HP:0011012)2.10339776
94Abnormality of glycosaminoglycan metabolism (HP:0004371)2.10339776
95Abnormality of mucopolysaccharide metabolism (HP:0011020)2.10339776
96Hepatosplenomegaly (HP:0001433)2.09921450
97B lymphocytopenia (HP:0010976)2.07612720
98Premature loss of primary teeth (HP:0006323)2.06966587
99IgA deficiency (HP:0002720)2.06740808
100Malnutrition (HP:0004395)2.06382804

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.45424218
2MAP4K14.30758317
3BLK3.70817966
4TYK22.99914873
5BMPR22.78550170
6MAP3K142.69514023
7KIT2.62242053
8ERN12.59133304
9CSF1R2.50620693
10SYK2.33282454
11TBK12.29374817
12JAK32.22622295
13FES2.17177123
14IRAK42.12280242
15BTK2.01165079
16CSK1.99465591
17IKBKE1.98089177
18MAP3K131.95532682
19IKBKB1.92503392
20PRPF4B1.87808196
21TXK1.83133176
22LYN1.77322548
23TAOK31.70026963
24ZAP701.66646810
25CDK191.62415371
26MATK1.59247638
27JAK11.53217737
28MAP2K31.49368886
29TEC1.42846149
30TNK21.36381537
31GRK61.36248704
32ITK1.35958826
33HCK1.35938861
34FGR1.34277222
35LCK1.29834194
36NME21.27631241
37GRK71.23426827
38MAP3K111.13154705
39JAK21.09504660
40MAP3K31.07340778
41SIK31.06822593
42CDC42BPA1.00476036
43TLK10.95163804
44IRAK30.92052689
45TGFBR20.91578839
46TAOK20.90348661
47KDR0.86187406
48MARK30.83606223
49TESK20.83053877
50PRKCQ0.80774780
51MAP3K10.78029629
52PDK10.75371353
53PIK3CG0.72062520
54MAPK70.69036218
55TAOK10.68213517
56SIK20.65513384
57CHUK0.64416507
58RIPK10.62711172
59MAPK120.61822562
60PIM10.59318758
61PDPK10.57718419
62FGFR30.55611268
63FYN0.54520386
64ABL10.53008492
65HIPK20.52719852
66ACVR1B0.52211682
67STK100.50684499
68ADRBK20.50571154
69FGFR40.49855367
70IRAK10.49106386
71DDR20.46693993
72DAPK30.46271647
73MAPK110.44832964
74TRPM70.44670726
75PIM20.44649339
76LRRK20.43732646
77PRKCD0.41530776
78RPS6KC10.39382683
79RPS6KL10.39382683
80CDK40.38451582
81EGFR0.36291998
82MAP2K60.36108676
83MAP3K50.35653994
84SMG10.35368346
85EPHB10.35171913
86MAPK40.34893746
87MAPKAPK20.34046974
88CDK60.33755128
89RPS6KA60.33458425
90IGF1R0.32495999
91MAP3K100.31241873
92MOS0.29701663
93BCKDK0.29390755
94DAPK20.28583064
95NEK90.26860364
96STK240.25864103
97CAMKK10.25059867
98INSR0.24990251
99MAP3K120.23918168
100YES10.23851161

Predicted pathways (KEGG)

RankGene SetZ-score
1* Asthma_Homo sapiens_hsa053105.14872481
2* Allograft rejection_Homo sapiens_hsa053304.84277600
3* Autoimmune thyroid disease_Homo sapiens_hsa053204.47202157
4* Graft-versus-host disease_Homo sapiens_hsa053324.44226605
5* Intestinal immune network for IgA production_Homo sapiens_hsa046724.09052733
6* Type I diabetes mellitus_Homo sapiens_hsa049403.74207442
7* Staphylococcus aureus infection_Homo sapiens_hsa051503.72872973
8* Leishmaniasis_Homo sapiens_hsa051403.14386844
9* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.90548962
10* Antigen processing and presentation_Homo sapiens_hsa046122.86142631
11* Viral myocarditis_Homo sapiens_hsa054162.71383483
12* Rheumatoid arthritis_Homo sapiens_hsa053232.31766683
13Primary immunodeficiency_Homo sapiens_hsa053402.09412044
14* Tuberculosis_Homo sapiens_hsa051521.94092589
15Hematopoietic cell lineage_Homo sapiens_hsa046401.84269599
16* Toxoplasmosis_Homo sapiens_hsa051451.73527672
17Osteoclast differentiation_Homo sapiens_hsa043801.68462080
18B cell receptor signaling pathway_Homo sapiens_hsa046621.61492611
19Other glycan degradation_Homo sapiens_hsa005111.56014200
20* Influenza A_Homo sapiens_hsa051641.54362838
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48216624
22* Herpes simplex infection_Homo sapiens_hsa051681.47161646
23* Phagosome_Homo sapiens_hsa041451.42751165
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.41591349
25* Systemic lupus erythematosus_Homo sapiens_hsa053221.41084826
26* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14807549
27Lysosome_Homo sapiens_hsa041421.13202508
28Pertussis_Homo sapiens_hsa051331.12517665
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06024514
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00384071
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96516707
32Malaria_Homo sapiens_hsa051440.93339502
33Measles_Homo sapiens_hsa051620.92838564
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92374471
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89294479
36Legionellosis_Homo sapiens_hsa051340.85514055
37Chemokine signaling pathway_Homo sapiens_hsa040620.84196981
38African trypanosomiasis_Homo sapiens_hsa051430.79663527
39TNF signaling pathway_Homo sapiens_hsa046680.78579236
40* Epstein-Barr virus infection_Homo sapiens_hsa051690.74735302
41Glycosaminoglycan degradation_Homo sapiens_hsa005310.74162085
42T cell receptor signaling pathway_Homo sapiens_hsa046600.71396705
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71233991
44Jak-STAT signaling pathway_Homo sapiens_hsa046300.69511196
45Salmonella infection_Homo sapiens_hsa051320.66486924
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66438047
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63495394
48Hepatitis C_Homo sapiens_hsa051600.54931364
49Shigellosis_Homo sapiens_hsa051310.51435246
50Platelet activation_Homo sapiens_hsa046110.51396025
51Acute myeloid leukemia_Homo sapiens_hsa052210.50507636
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49669287
53* HTLV-I infection_Homo sapiens_hsa051660.49329173
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47631449
55Apoptosis_Homo sapiens_hsa042100.46065799
56Hepatitis B_Homo sapiens_hsa051610.46058894
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.45526875
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37874960
59Arachidonic acid metabolism_Homo sapiens_hsa005900.34156187
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30965650
61Renin-angiotensin system_Homo sapiens_hsa046140.30088533
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29008256
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28500986
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28233945
65Complement and coagulation cascades_Homo sapiens_hsa046100.28038718
66Collecting duct acid secretion_Homo sapiens_hsa049660.25781955
67Viral carcinogenesis_Homo sapiens_hsa052030.25224227
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20917547
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.20823146
70Prolactin signaling pathway_Homo sapiens_hsa049170.15188767
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14641852
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.14348396
73Linoleic acid metabolism_Homo sapiens_hsa005910.14323096
74Amoebiasis_Homo sapiens_hsa051460.13488798
75Endocytosis_Homo sapiens_hsa041440.11788416
76VEGF signaling pathway_Homo sapiens_hsa043700.11177933
77Ether lipid metabolism_Homo sapiens_hsa005650.11104118
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.10661317
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.08419437
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.08018134
81Sphingolipid metabolism_Homo sapiens_hsa006000.07118375
82PPAR signaling pathway_Homo sapiens_hsa033200.06096445
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.05398813
84Pancreatic cancer_Homo sapiens_hsa052120.04264219
85Non-small cell lung cancer_Homo sapiens_hsa052230.03338592
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.03051214
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.02636331
88Galactose metabolism_Homo sapiens_hsa000520.02424055
89Tryptophan metabolism_Homo sapiens_hsa003800.02085952
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.02057486
91Fat digestion and absorption_Homo sapiens_hsa049750.01155262
92Vitamin digestion and absorption_Homo sapiens_hsa049770.00938215
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.00655472
94Prion diseases_Homo sapiens_hsa050200.00592019
95Mineral absorption_Homo sapiens_hsa049780.00473384
96Bacterial invasion of epithelial cells_Homo sapiens_hsa05100-0.0199270
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750-0.0175031
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0064229
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0037854
100HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0033065

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