HLA-DRA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)7.13997525
2B cell mediated immunity (GO:0019724)5.65283789
3* interferon-gamma-mediated signaling pathway (GO:0060333)5.35259386
4antigen processing and presentation of endogenous antigen (GO:0019883)5.18073078
5regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.17123602
6regulation of antigen processing and presentation (GO:0002577)4.85817259
7positive regulation of gamma-delta T cell activation (GO:0046645)4.84588907
8detection of bacterium (GO:0016045)4.76570500
9detection of other organism (GO:0098543)4.69463121
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.65579858
11regulation of dendritic cell antigen processing and presentation (GO:0002604)4.59851984
12positive regulation by symbiont of host defense response (GO:0052509)4.58559186
13modulation by symbiont of host defense response (GO:0052031)4.58559186
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.58559186
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.58559186
16positive regulation by organism of defense response of other organism involved in symbiotic interact4.58559186
17modulation by symbiont of host immune response (GO:0052553)4.58559186
18positive regulation of antigen processing and presentation (GO:0002579)4.55476806
19regulation of B cell receptor signaling pathway (GO:0050855)4.49865367
20T-helper 1 type immune response (GO:0042088)4.43576430
21neutrophil activation involved in immune response (GO:0002283)4.40384052
22positive thymic T cell selection (GO:0045059)4.30256648
23response to peptidoglycan (GO:0032494)4.22976546
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.22304375
25macrophage activation involved in immune response (GO:0002281)4.22297425
26* cellular response to interferon-gamma (GO:0071346)4.22265196
27positive regulation of type 2 immune response (GO:0002830)4.12543440
28positive regulation of mast cell activation (GO:0033005)4.10227652
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.06949812
30positive regulation of mast cell degranulation (GO:0043306)4.06432839
31positive regulation of mast cell activation involved in immune response (GO:0033008)4.06432839
32regulation of hypersensitivity (GO:0002883)3.97757732
33B cell receptor signaling pathway (GO:0050853)3.92957650
34* T cell costimulation (GO:0031295)3.92194754
35detection of external biotic stimulus (GO:0098581)3.87178973
36regulation of interferon-beta biosynthetic process (GO:0045357)3.87022264
37* lymphocyte costimulation (GO:0031294)3.86439030
38* response to interferon-gamma (GO:0034341)3.78570208
39negative regulation of cell killing (GO:0031342)3.75224948
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.75224948
41negative regulation of interleukin-12 production (GO:0032695)3.70042520
42positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.65853706
43type I interferon signaling pathway (GO:0060337)3.61919557
44cellular response to type I interferon (GO:0071357)3.61919557
45response to type I interferon (GO:0034340)3.57935913
46regulation of mast cell degranulation (GO:0043304)3.56726710
47microglial cell activation (GO:0001774)3.53943445
48positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.50093932
49production of molecular mediator of immune response (GO:0002440)3.46890133
50regulation of mast cell activation (GO:0033003)3.46066291
51positive regulation of B cell differentiation (GO:0045579)3.44222077
52regulation of gamma-delta T cell activation (GO:0046643)3.44110992
53defense response to protozoan (GO:0042832)3.44007965
54detection of biotic stimulus (GO:0009595)3.42118409
55response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.35482160
56response to host immune response (GO:0052572)3.35482160
57myeloid cell activation involved in immune response (GO:0002275)3.33647182
58positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.32875304
59positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.32167598
60adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.30727368
61regulation of mast cell activation involved in immune response (GO:0033006)3.28846806
62regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.27008937
63negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.26504612
64positive regulation of interferon-alpha production (GO:0032727)3.26370877
65positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.25723900
66detection of molecule of bacterial origin (GO:0032490)3.24000175
67regulation of interferon-alpha production (GO:0032647)3.23348929
68myeloid dendritic cell activation (GO:0001773)3.22114363
69positive regulation of macrophage cytokine production (GO:0060907)3.20155704
70response to protozoan (GO:0001562)3.19917729
71regulation of inflammatory response to antigenic stimulus (GO:0002861)3.19435934
72regulation of T cell tolerance induction (GO:0002664)3.16977465
73positive T cell selection (GO:0043368)3.15232761
74negative thymic T cell selection (GO:0045060)3.14742993
75regulation of alpha-beta T cell proliferation (GO:0046640)3.14427551
76positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.11660389
77antigen processing and presentation via MHC class Ib (GO:0002475)3.10166250
78T cell migration (GO:0072678)3.09444742
79regulation of tolerance induction (GO:0002643)3.07188002
80myeloid dendritic cell differentiation (GO:0043011)3.04585576
81* antigen receptor-mediated signaling pathway (GO:0050851)3.04056428
82positive regulation of leukocyte degranulation (GO:0043302)3.03824895
83regulation of B cell differentiation (GO:0045577)3.02836288
84response to host (GO:0075136)3.01557528
85response to host defenses (GO:0052200)3.01557528
86response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.01557528
87chaperone mediated protein folding requiring cofactor (GO:0051085)3.00470843
88regulation of T-helper 1 cell differentiation (GO:0045625)3.00417007
89lipopolysaccharide-mediated signaling pathway (GO:0031663)2.97559805
90regulation of type 2 immune response (GO:0002828)2.97045014
91regulation of myeloid leukocyte mediated immunity (GO:0002886)2.95144183
92positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.94482946
93adaptive immune response (GO:0002250)2.92063145
94positive regulation of interferon-gamma production (GO:0032729)2.91890871
95germinal center formation (GO:0002467)2.90914043
96macrophage activation (GO:0042116)2.90874805
97negative T cell selection (GO:0043383)2.89677237
98positive regulation of immunoglobulin mediated immune response (GO:0002891)2.87896186
99positive regulation of B cell mediated immunity (GO:0002714)2.87896186
100response to muramyl dipeptide (GO:0032495)2.87428520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human7.73453726
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.97696716
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.14048926
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.22665255
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.84452838
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.67808165
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.59361856
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.33329785
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.20813495
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.16596193
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.04495049
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.93420215
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.80714127
14SPI1_23547873_ChIP-Seq_NB4_Human2.66515708
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.63518716
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.62224672
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.53480413
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.46387752
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.45789749
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.42626810
21MYB_26560356_Chip-Seq_TH2_Human2.39951918
22SCL_19346495_ChIP-Seq_HPC-7_Human2.27835538
23VDR_24763502_ChIP-Seq_THP-1_Human2.23029562
24RUNX_20019798_ChIP-Seq_JUKART_Human2.16900234
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.08008284
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.06401686
27SPI1_23127762_ChIP-Seq_K562_Human2.05098286
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.95748507
29MYC_22102868_ChIP-Seq_BL_Human1.95419038
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.93814620
31MAF_26560356_Chip-Seq_TH1_Human1.92682558
32VDR_21846776_ChIP-Seq_THP-1_Human1.91419465
33MYB_26560356_Chip-Seq_TH1_Human1.90041528
34VDR_24787735_ChIP-Seq_THP-1_Human1.88294091
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86582459
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81347145
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.79373710
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.75391895
39GATA3_27048872_Chip-Seq_THYMUS_Human1.65313660
40* CIITA_25753668_ChIP-Seq_RAJI_Human1.64299105
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60306029
42GATA1_22025678_ChIP-Seq_K562_Human1.60196461
43GATA3_26560356_Chip-Seq_TH2_Human1.50437052
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50148646
45UTX_26944678_Chip-Seq_JUKART_Human1.49526472
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48422536
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46248854
48CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43759569
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41304418
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41149065
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33979609
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32686417
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.30715636
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26385266
55PU_27001747_Chip-Seq_BMDM_Mouse1.23318820
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21187131
57CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18793859
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18638646
59MAF_26560356_Chip-Seq_TH2_Human1.18261001
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17401164
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16289140
62VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14272263
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.12954090
64CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12339704
65SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10740715
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09273628
67STAT1_20625510_ChIP-Seq_HELA_Human1.07760011
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07065507
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03504629
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.02737632
71TCF7_22412390_ChIP-Seq_EML_Mouse1.00463773
72BCL6_27268052_Chip-Seq_Bcells_Human1.00089717
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99722313
74EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98852371
75PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96291228
76KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95968698
77GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95185332
78IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93282425
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91634325
80SMRT_27268052_Chip-Seq_Bcells_Human0.88782040
81GATA2_21666600_ChIP-Seq_HMVEC_Human0.87878582
82SPI1_20517297_ChIP-Seq_HL60_Human0.84552862
83TFEB_21752829_ChIP-Seq_HELA_Human0.84541117
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83595972
85BCOR_27268052_Chip-Seq_Bcells_Human0.82408953
86GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79538360
87ELF1_20517297_ChIP-Seq_JURKAT_Human0.78160451
88EGR1_19032775_ChIP-ChIP_M12_Human0.77560276
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77180397
90P300_27268052_Chip-Seq_Bcells_Human0.76286145
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.75291377
92GATA1_19941826_ChIP-Seq_K562_Human0.74969212
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74660340
94LXR_22292898_ChIP-Seq_THP-1_Human0.70164795
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.67537251
96CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67280610
97SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.65267280
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.65106089
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.64514088
100KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.64488147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.39702643
2MP0005671_abnormal_response_to3.85599655
3MP0003303_peritoneal_inflammation3.46653996
4MP0005387_immune_system_phenotype3.39474338
5MP0001790_abnormal_immune_system3.39474338
6MP0001800_abnormal_humoral_immune3.35589471
7MP0000685_abnormal_immune_system3.31093536
8MP0003724_increased_susceptibility_to3.22635277
9MP0002148_abnormal_hypersensitivity_rea3.15760023
10MP0003436_decreased_susceptibility_to3.13770422
11MP0005000_abnormal_immune_tolerance3.13535903
12MP0009785_altered_susceptibility_to3.11554508
13MP0002452_abnormal_antigen_presenting2.93959585
14MP0002419_abnormal_innate_immunity2.80990531
15MP0005025_abnormal_response_to2.79415361
16MP0002723_abnormal_immune_serum2.75670211
17MP0006082_CNS_inflammation2.61702975
18MP0002420_abnormal_adaptive_immunity2.49451941
19MP0001819_abnormal_immune_cell2.48742313
20MP0010155_abnormal_intestine_physiology2.15604130
21MP0002166_altered_tumor_susceptibility2.09769241
22MP0003300_gastrointestinal_ulcer1.97939324
23MP0001845_abnormal_inflammatory_respons1.91258119
24MP0000716_abnormal_immune_system1.90724738
25MP0005464_abnormal_platelet_physiology1.85510312
26MP0002138_abnormal_hepatobiliary_system1.84518224
27MP0002398_abnormal_bone_marrow1.83833774
28MP0009764_decreased_sensitivity_to1.83544702
29MP0005058_abnormal_lysosome_morphology1.81169313
30MP0003183_abnormal_peptide_metabolism1.76592958
31MP0003075_altered_response_to1.76266158
32MP0003763_abnormal_thymus_physiology1.73313067
33MP0003172_abnormal_lysosome_physiology1.71683297
34MP0002405_respiratory_system_inflammati1.71553994
35MP0003191_abnormal_cellular_cholesterol1.60817441
36MP0008469_abnormal_protein_level1.60480998
37MP0001533_abnormal_skeleton_physiology1.59662347
38MP0009333_abnormal_splenocyte_physiolog1.58460682
39MP0004947_skin_inflammation1.57608471
40MP0001853_heart_inflammation1.57043072
41MP0005166_decreased_susceptibility_to1.52562264
42MP0002006_tumorigenesis1.52363461
43MP0003806_abnormal_nucleotide_metabolis1.50461411
44MP0000689_abnormal_spleen_morphology1.50429276
45MP0002429_abnormal_blood_cell1.50230390
46MP0000465_gastrointestinal_hemorrhage1.36999997
47MP0003866_abnormal_defecation1.36922988
48MP0005397_hematopoietic_system_phenotyp1.33600205
49MP0001545_abnormal_hematopoietic_system1.33600205
50MP0002722_abnormal_immune_system1.33338686
51MP0005310_abnormal_salivary_gland1.28399754
52MP0001873_stomach_inflammation1.23810159
53MP0000858_altered_metastatic_potential1.23307666
54MP0000343_altered_response_to1.23174228
55MP0009840_abnormal_foam_cell1.22162536
56MP0002139_abnormal_hepatobiliary_system1.20504404
57MP0009278_abnormal_bone_marrow1.19059848
58MP0002998_abnormal_bone_remodeling1.17223948
59MP0005451_abnormal_body_composition1.10376221
60MP0002396_abnormal_hematopoietic_system1.05932591
61MP0003828_pulmonary_edema1.01161153
62MP0003448_altered_tumor_morphology0.96066684
63MP0000604_amyloidosis0.95604178
64MP0008004_abnormal_stomach_pH0.94950151
65MP0009763_increased_sensitivity_to0.94780598
66MP0008260_abnormal_autophagy0.92943192
67MP0001663_abnormal_digestive_system0.88295525
68MP0005165_increased_susceptibility_to0.87256076
69MP0000249_abnormal_blood_vessel0.86053796
70MP0000703_abnormal_thymus_morphology0.85432103
71MP0005075_abnormal_melanosome_morpholog0.78805320
72MP0003045_fibrosis0.78695068
73MP0005360_urolithiasis0.74564353
74MP0004883_abnormal_blood_vessel0.73459417
75MP0002132_abnormal_respiratory_system0.73443966
76MP0003690_abnormal_glial_cell0.71188880
77MP0001851_eye_inflammation0.69285655
78MP0002009_preneoplasia0.68829170
79MP0002136_abnormal_kidney_physiology0.67635932
80MP0005167_abnormal_blood-brain_barrier0.67608587
81MP0005164_abnormal_response_to0.66684180
82MP0004808_abnormal_hematopoietic_stem0.66564338
83MP0004510_myositis0.66184082
84MP0009765_abnormal_xenobiotic_induced0.63260118
85MP0000490_abnormal_crypts_of0.62842916
86MP0003091_abnormal_cell_migration0.62581795
87MP0000015_abnormal_ear_pigmentation0.62330961
88MP0009643_abnormal_urine_homeostasis0.61246297
89MP0000920_abnormal_myelination0.61095244
90MP0002933_joint_inflammation0.60726654
91MP0005584_abnormal_enzyme/coenzyme_acti0.60045857
92MP0005390_skeleton_phenotype0.59510262
93MP0000569_abnormal_digit_pigmentation0.58897646
94MP0003252_abnormal_bile_duct0.56726588
95MP0003795_abnormal_bone_structure0.55337979
96MP0002019_abnormal_tumor_incidence0.55137567
97MP0000609_abnormal_liver_physiology0.54385979
98MP0005319_abnormal_enzyme/_coenzyme0.52028180
99MP0000371_diluted_coat_color0.51466549
100MP0005535_abnormal_body_temperature0.50482801

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.87447480
2Recurrent abscess formation (HP:0002722)4.64282822
3Meningitis (HP:0001287)4.63076668
4Eczematoid dermatitis (HP:0000976)4.53170196
5Agammaglobulinemia (HP:0004432)4.52769938
6Abnormality of macrophages (HP:0004311)4.30073045
7Vasculitis (HP:0002633)4.23475241
8Mediastinal lymphadenopathy (HP:0100721)4.22090794
9Obstructive lung disease (HP:0006536)4.07867405
10Chronic obstructive pulmonary disease (HP:0006510)4.07867405
11Systemic lupus erythematosus (HP:0002725)3.96260292
12Pulmonary infiltrates (HP:0002113)3.95595986
13Chronic mucocutaneous candidiasis (HP:0002728)3.86288631
14Recurrent cutaneous fungal infections (HP:0011370)3.86288631
15Abnormality of the prostate (HP:0008775)3.82001199
16Recurrent fungal infections (HP:0002841)3.79927740
17Elevated erythrocyte sedimentation rate (HP:0003565)3.69355298
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.66473788
19Recurrent skin infections (HP:0001581)3.64565008
20Gastrointestinal stroma tumor (HP:0100723)3.63422010
21Myositis (HP:0100614)3.62312809
22Recurrent gram-negative bacterial infections (HP:0005420)3.57847612
23Panhypogammaglobulinemia (HP:0003139)3.57296708
24Abnormality of liposaccharide metabolism (HP:0010968)3.55051792
25Abnormality of glycosphingolipid metabolism (HP:0004343)3.55051792
26Abnormality of glycolipid metabolism (HP:0010969)3.55051792
27Hemoptysis (HP:0002105)3.52793424
28Urticaria (HP:0001025)3.51487989
29Recurrent viral infections (HP:0004429)3.49763357
30Optic neuritis (HP:0100653)3.42076391
31Retrobulbar optic neuritis (HP:0100654)3.42076391
32Orchitis (HP:0100796)3.39499381
33Chest pain (HP:0100749)3.33369050
34Recurrent bronchitis (HP:0002837)3.28016297
35Gastrointestinal infarctions (HP:0005244)3.28010007
36Colitis (HP:0002583)3.22468333
37Recurrent sinusitis (HP:0011108)3.13294530
38Cellulitis (HP:0100658)3.10697662
39Restrictive lung disease (HP:0002091)3.02159953
40Increased cerebral lipofuscin (HP:0011813)3.02077841
41Abnormality of the pleura (HP:0002103)2.98038856
42Encephalitis (HP:0002383)2.95536587
43Chronic diarrhea (HP:0002028)2.81315097
44Inflammation of the large intestine (HP:0002037)2.78774913
45Gangrene (HP:0100758)2.78186008
46Skin rash (HP:0000988)2.74824876
47Osteomyelitis (HP:0002754)2.74164810
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.70124916
49Stomatitis (HP:0010280)2.69951873
50Increased IgM level (HP:0003496)2.68035161
51Pulmonary fibrosis (HP:0002206)2.65375368
52Vacuolated lymphocytes (HP:0001922)2.63817317
53Gastrointestinal inflammation (HP:0004386)2.62921318
54Pulmonary embolism (HP:0002204)2.56567396
55Xerostomia (HP:0000217)2.55253208
56Increased IgE level (HP:0003212)2.53303519
57Autoimmune thrombocytopenia (HP:0001973)2.52599607
58Recurrent pneumonia (HP:0006532)2.51673606
59Spontaneous hematomas (HP:0007420)2.51581752
60Amyloidosis (HP:0011034)2.50950686
61Lymphopenia (HP:0001888)2.49996925
62Keratoconjunctivitis sicca (HP:0001097)2.48470152
63Abnormality of T cell number (HP:0011839)2.48022966
64Abnormality of B cell number (HP:0010975)2.47398760
65IgM deficiency (HP:0002850)2.45260440
66Abnormality of T cells (HP:0002843)2.42816994
67Abnormality of cells of the lymphoid lineage (HP:0012140)2.42657505
68Loss of speech (HP:0002371)2.42423108
69Arterial thrombosis (HP:0004420)2.41324322
70Recurrent lower respiratory tract infections (HP:0002783)2.39898259
71Abnormality of T cell physiology (HP:0011840)2.39893884
72T lymphocytopenia (HP:0005403)2.38511259
73Gingivitis (HP:0000230)2.36981407
74Chronic otitis media (HP:0000389)2.36305195
75Epistaxis (HP:0000421)2.34951074
76Hypertensive crisis (HP:0100735)2.33272413
77Hypergammaglobulinemia (HP:0010702)2.32638363
78Dysostosis multiplex (HP:0000943)2.31527005
79Polyneuropathy (HP:0001271)2.30185210
80Pustule (HP:0200039)2.29860293
81Petechiae (HP:0000967)2.29580075
82Keratoconjunctivitis (HP:0001096)2.29438891
83Emphysema (HP:0002097)2.28562399
84IgG deficiency (HP:0004315)2.27625339
85Papilloma (HP:0012740)2.27350509
86Verrucae (HP:0200043)2.27350509
87Skin ulcer (HP:0200042)2.23416354
88Abnormality of male internal genitalia (HP:0000022)2.21942230
89B lymphocytopenia (HP:0010976)2.20719196
90Glomerulopathy (HP:0100820)2.20710470
91Arthralgia (HP:0002829)2.20337145
92Leukocytosis (HP:0001974)2.19799273
93Acrocyanosis (HP:0001063)2.19577334
94Amaurosis fugax (HP:0100576)2.19568571
95Premature loss of primary teeth (HP:0006323)2.18417596
96Abnormality of the peritoneum (HP:0002585)2.16544887
97Glomerulonephritis (HP:0000099)2.16439898
98Purpura (HP:0000979)2.16257843
99Chronic sinusitis (HP:0011109)2.10725051
100Fatigue (HP:0012378)2.09660573

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.49559693
2BLK4.18827158
3MAP4K14.06191097
4BMPR23.42746441
5TYK23.08634040
6MAP3K143.02309708
7KIT2.81699296
8CSF1R2.74773289
9SYK2.43093159
10ERN12.26158489
11JAK32.24529370
12MAP3K132.21377292
13TBK12.09875527
14IRAK42.08658095
15CDK192.02457964
16BTK1.93415662
17IKBKB1.93404214
18PRPF4B1.93187950
19IKBKE1.91822626
20FES1.91581997
21CSK1.89195022
22LYN1.83332145
23JAK11.75459642
24TAOK31.68789087
25MATK1.63951588
26TXK1.55203479
27ZAP701.54208946
28TEC1.45116938
29SIK31.37631506
30HCK1.36486158
31ITK1.29354991
32FGR1.23739863
33LCK1.20331959
34JAK21.12262283
35GRK61.10260224
36GRK71.07934566
37MAP2K31.06353663
38TLK11.01023158
39IRAK30.95953817
40MAP3K30.95330582
41TNK20.93441882
42NME20.90469966
43CDC42BPA0.89553670
44PIK3CG0.89050548
45PRKCQ0.82007299
46FGFR30.76264746
47EIF2AK30.72963430
48PDK10.72892273
49TRPM70.71680483
50TAOK20.71666037
51CHUK0.71223058
52MAPK70.70154436
53KDR0.69722217
54MAP3K120.67661098
55MARK30.67256289
56ABL10.63655993
57MAPK120.61436079
58STK240.58910882
59MAP3K10.57252289
60PIM10.57078806
61FGFR40.56447914
62IRAK10.56270817
63STK100.54844190
64PDPK10.54118970
65SIK20.53145758
66SCYL20.51820586
67TESK20.50599862
68FYN0.50356695
69TGFBR20.49256371
70CDK60.47884148
71MAPK110.47797362
72PRKCD0.46262414
73EGFR0.46193826
74MST40.46010927
75NEK90.45406861
76MAP3K100.44558764
77MAP3K110.44361152
78DAPK30.44127667
79DDR20.43407469
80RIPK10.43161898
81SMG10.41144813
82IGF1R0.41093445
83ARAF0.40352450
84LRRK20.39694400
85RPS6KA50.39500027
86HIPK20.37881938
87CDK40.37525923
88YES10.37224959
89CCNB10.37138066
90MAPK40.36958597
91MOS0.36456839
92MAPKAPK20.36185968
93ADRBK20.34206257
94OXSR10.33988780
95PIM20.30274988
96RPS6KL10.27512196
97RPS6KC10.27512196
98MAP3K50.27366109
99DAPK10.24917597
100INSR0.23275699

Predicted pathways (KEGG)

RankGene SetZ-score
1* Asthma_Homo sapiens_hsa053105.58963937
2* Allograft rejection_Homo sapiens_hsa053305.02961200
3* Autoimmune thyroid disease_Homo sapiens_hsa053204.69182925
4* Graft-versus-host disease_Homo sapiens_hsa053324.64228829
5* Intestinal immune network for IgA production_Homo sapiens_hsa046724.33090263
6* Type I diabetes mellitus_Homo sapiens_hsa049403.96472500
7* Staphylococcus aureus infection_Homo sapiens_hsa051503.71471772
8* Leishmaniasis_Homo sapiens_hsa051403.17040770
9* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.02818918
10* Antigen processing and presentation_Homo sapiens_hsa046122.92933687
11* Viral myocarditis_Homo sapiens_hsa054162.90054540
12* Rheumatoid arthritis_Homo sapiens_hsa053232.35392023
13* Tuberculosis_Homo sapiens_hsa051521.92082752
14Primary immunodeficiency_Homo sapiens_hsa053401.87611350
15* Toxoplasmosis_Homo sapiens_hsa051451.75429718
16* Influenza A_Homo sapiens_hsa051641.64253580
17* Hematopoietic cell lineage_Homo sapiens_hsa046401.60179123
18B cell receptor signaling pathway_Homo sapiens_hsa046621.55124012
19* Herpes simplex infection_Homo sapiens_hsa051681.51889882
20* Systemic lupus erythematosus_Homo sapiens_hsa053221.50419660
21Osteoclast differentiation_Homo sapiens_hsa043801.46292944
22* Phagosome_Homo sapiens_hsa041451.42974800
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42172614
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.32794596
25* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14140064
26Other glycan degradation_Homo sapiens_hsa005111.09713832
27Pertussis_Homo sapiens_hsa051331.03277026
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02243179
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91460342
30Measles_Homo sapiens_hsa051620.91433579
31Legionellosis_Homo sapiens_hsa051340.88121049
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87154474
33Lysosome_Homo sapiens_hsa041420.86387223
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78134355
35* Epstein-Barr virus infection_Homo sapiens_hsa051690.77704761
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77382895
37Malaria_Homo sapiens_hsa051440.76315943
38Chemokine signaling pathway_Homo sapiens_hsa040620.74260444
39African trypanosomiasis_Homo sapiens_hsa051430.71054797
40TNF signaling pathway_Homo sapiens_hsa046680.68052705
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63672974
42Jak-STAT signaling pathway_Homo sapiens_hsa046300.63000320
43Salmonella infection_Homo sapiens_hsa051320.62174065
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61579648
45T cell receptor signaling pathway_Homo sapiens_hsa046600.58558621
46Glycosaminoglycan degradation_Homo sapiens_hsa005310.52693674
47Shigellosis_Homo sapiens_hsa051310.51949260
48* HTLV-I infection_Homo sapiens_hsa051660.49266879
49Hepatitis C_Homo sapiens_hsa051600.48828390
50Hepatitis B_Homo sapiens_hsa051610.47504507
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44632545
52Apoptosis_Homo sapiens_hsa042100.42805259
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41257991
54Platelet activation_Homo sapiens_hsa046110.40017612
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.36704491
56Acute myeloid leukemia_Homo sapiens_hsa052210.31946542
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31413769
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30689966
59Viral carcinogenesis_Homo sapiens_hsa052030.23932376
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.21807808
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21362611
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21121440
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20525096
64Complement and coagulation cascades_Homo sapiens_hsa046100.19044072
65Arachidonic acid metabolism_Homo sapiens_hsa005900.17390526
66Renin-angiotensin system_Homo sapiens_hsa046140.17336676
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16912005
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12642824
69Prolactin signaling pathway_Homo sapiens_hsa049170.11182228
70Collecting duct acid secretion_Homo sapiens_hsa049660.11166050
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09854784
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.07442946
73Sphingolipid metabolism_Homo sapiens_hsa006000.06816725
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.06344602
75Endocytosis_Homo sapiens_hsa041440.05780656
76Amoebiasis_Homo sapiens_hsa051460.05678424
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.05573931
78Pancreatic cancer_Homo sapiens_hsa052120.03513966
79Linoleic acid metabolism_Homo sapiens_hsa005910.01462868
80Non-small cell lung cancer_Homo sapiens_hsa052230.01264792
81VEGF signaling pathway_Homo sapiens_hsa043700.01263176
82Ether lipid metabolism_Homo sapiens_hsa005650.00651533
83HIF-1 signaling pathway_Homo sapiens_hsa040660.00408999
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.00140046
85Proteasome_Homo sapiens_hsa03050-0.0668040
86Pentose phosphate pathway_Homo sapiens_hsa00030-0.0654655
87Vitamin digestion and absorption_Homo sapiens_hsa04977-0.0626877
88Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0559145
89Galactose metabolism_Homo sapiens_hsa00052-0.0558645
90Histidine metabolism_Homo sapiens_hsa00340-0.0518332
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0516488
92Bladder cancer_Homo sapiens_hsa05219-0.0488144
93PPAR signaling pathway_Homo sapiens_hsa03320-0.0387910
94Phospholipase D signaling pathway_Homo sapiens_hsa04072-0.0349029
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0317359
96Bacterial invasion of epithelial cells_Homo sapiens_hsa05100-0.0203869
97Mineral absorption_Homo sapiens_hsa04978-0.0201543
98Regulation of autophagy_Homo sapiens_hsa04140-0.0089081
99Tryptophan metabolism_Homo sapiens_hsa00380-0.0066613
100Drug metabolism - other enzymes_Homo sapiens_hsa00983-0.0065855

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