Rank | Gene Set | Z-score |
---|---|---|
1 | * immunoglobulin mediated immune response (GO:0016064) | 5.82625779 |
2 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.53589799 |
3 | positive regulation of gamma-delta T cell activation (GO:0046645) | 5.13036074 |
4 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 4.87932076 |
5 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 4.80089423 |
6 | * interferon-gamma-mediated signaling pathway (GO:0060333) | 4.76420064 |
7 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.74529623 |
8 | regulation of antigen processing and presentation (GO:0002577) | 4.70804595 |
9 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 4.58993600 |
10 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 4.58414207 |
11 | positive regulation of antigen processing and presentation (GO:0002579) | 4.55460557 |
12 | * B cell mediated immunity (GO:0019724) | 4.44847196 |
13 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 4.37187180 |
14 | negative regulation of cell killing (GO:0031342) | 4.37187180 |
15 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 4.37060135 |
16 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 4.37060135 |
17 | modulation by symbiont of host immune response (GO:0052553) | 4.37060135 |
18 | positive regulation by symbiont of host defense response (GO:0052509) | 4.37060135 |
19 | modulation by symbiont of host defense response (GO:0052031) | 4.37060135 |
20 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 4.37060135 |
21 | response to peptidoglycan (GO:0032494) | 4.31946208 |
22 | macrophage activation involved in immune response (GO:0002281) | 4.17816534 |
23 | positive thymic T cell selection (GO:0045059) | 4.17032530 |
24 | neutrophil activation involved in immune response (GO:0002283) | 4.11866892 |
25 | negative regulation of interleukin-12 production (GO:0032695) | 3.95685616 |
26 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.94153493 |
27 | cellular response to type I interferon (GO:0071357) | 3.87808275 |
28 | type I interferon signaling pathway (GO:0060337) | 3.87808275 |
29 | response to type I interferon (GO:0034340) | 3.84298731 |
30 | * cellular response to interferon-gamma (GO:0071346) | 3.72722436 |
31 | B cell receptor signaling pathway (GO:0050853) | 3.71976949 |
32 | regulation of gamma-delta T cell activation (GO:0046643) | 3.69668806 |
33 | * detection of other organism (GO:0098543) | 3.67739960 |
34 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.67352986 |
35 | * detection of bacterium (GO:0016045) | 3.61574915 |
36 | positive regulation of B cell differentiation (GO:0045579) | 3.58334565 |
37 | positive regulation of type 2 immune response (GO:0002830) | 3.58209997 |
38 | defense response to protozoan (GO:0042832) | 3.47727927 |
39 | NIK/NF-kappaB signaling (GO:0038061) | 3.43242859 |
40 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.41893881 |
41 | * response to interferon-gamma (GO:0034341) | 3.38817656 |
42 | response to protozoan (GO:0001562) | 3.36452654 |
43 | * T cell costimulation (GO:0031295) | 3.28977268 |
44 | myeloid dendritic cell activation (GO:0001773) | 3.27395011 |
45 | * lymphocyte costimulation (GO:0031294) | 3.23856479 |
46 | positive regulation of interferon-alpha production (GO:0032727) | 3.21092816 |
47 | regulation of interferon-alpha production (GO:0032647) | 3.21049790 |
48 | myeloid dendritic cell differentiation (GO:0043011) | 3.19606253 |
49 | regulation of mast cell degranulation (GO:0043304) | 3.19588452 |
50 | response to host immune response (GO:0052572) | 3.16788906 |
51 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.16788906 |
52 | myeloid cell activation involved in immune response (GO:0002275) | 3.16736997 |
53 | negative thymic T cell selection (GO:0045060) | 3.15826122 |
54 | response to muramyl dipeptide (GO:0032495) | 3.14261531 |
55 | positive regulation of mast cell activation (GO:0033005) | 3.13955056 |
56 | positive regulation of macrophage cytokine production (GO:0060907) | 3.13791197 |
57 | * detection of external biotic stimulus (GO:0098581) | 3.12338761 |
58 | germinal center formation (GO:0002467) | 3.12028383 |
59 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.11036793 |
60 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 3.07508143 |
61 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.06066460 |
62 | positive T cell selection (GO:0043368) | 3.05051807 |
63 | microglial cell activation (GO:0001774) | 3.02264852 |
64 | regulation of T-helper 1 cell differentiation (GO:0045625) | 3.01603618 |
65 | T cell migration (GO:0072678) | 3.00365514 |
66 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 2.96710449 |
67 | regulation of B cell differentiation (GO:0045577) | 2.95526110 |
68 | regulation of mast cell activation (GO:0033003) | 2.95428553 |
69 | cellular extravasation (GO:0045123) | 2.95145137 |
70 | detection of molecule of bacterial origin (GO:0032490) | 2.94550840 |
71 | regulation of mast cell activation involved in immune response (GO:0033006) | 2.92160765 |
72 | regulation of T cell tolerance induction (GO:0002664) | 2.91695214 |
73 | negative T cell selection (GO:0043383) | 2.91090113 |
74 | positive regulation of mast cell degranulation (GO:0043306) | 2.90690933 |
75 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 2.90690933 |
76 | respiratory burst (GO:0045730) | 2.90145839 |
77 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 2.88601763 |
78 | response to host (GO:0075136) | 2.88601763 |
79 | response to host defenses (GO:0052200) | 2.88601763 |
80 | * T-helper 1 type immune response (GO:0042088) | 2.87552735 |
81 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 2.87507043 |
82 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 2.86182447 |
83 | T cell selection (GO:0045058) | 2.85802175 |
84 | macrophage activation (GO:0042116) | 2.85197693 |
85 | chaperone mediated protein folding requiring cofactor (GO:0051085) | 2.84868717 |
86 | regulation of type 2 immune response (GO:0002828) | 2.84024399 |
87 | positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:0061081 | 2.83680635 |
88 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.82788437 |
89 | regulation of tolerance induction (GO:0002643) | 2.82280915 |
90 | thymic T cell selection (GO:0045061) | 2.81901726 |
91 | * adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli | 2.80094474 |
92 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 2.78339147 |
93 | granulocyte activation (GO:0036230) | 2.78278342 |
94 | negative regulation of innate immune response (GO:0045824) | 2.75103598 |
95 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 2.73106115 |
96 | * detection of biotic stimulus (GO:0009595) | 2.72938641 |
97 | regulation of leukocyte degranulation (GO:0043300) | 2.72935549 |
98 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 2.72913510 |
99 | neutrophil activation (GO:0042119) | 2.71966099 |
100 | regulation of interleukin-12 production (GO:0032655) | 2.71094734 |
Rank | Gene Set | Z-score |
---|---|---|
1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 7.32218625 |
2 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 5.51857495 |
3 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 4.62606371 |
4 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.94797288 |
5 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 3.33401770 |
6 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.31123702 |
7 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.17886987 |
8 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.15183231 |
9 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.93872713 |
10 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.83622585 |
11 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.81745706 |
12 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.70122073 |
13 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.67639869 |
14 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.55886040 |
15 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.53798037 |
16 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.46834618 |
17 | VDR_24763502_ChIP-Seq_THP-1_Human | 2.44978079 |
18 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.39180379 |
19 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.32139989 |
20 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.31697036 |
21 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 2.20084886 |
22 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.17464750 |
23 | MYC_22102868_ChIP-Seq_BL_Human | 2.15615147 |
24 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.11547730 |
25 | MYB_26560356_Chip-Seq_TH2_Human | 2.11248113 |
26 | SPI1_23127762_ChIP-Seq_K562_Human | 2.07968081 |
27 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 2.07357160 |
28 | MAF_26560356_Chip-Seq_TH1_Human | 2.04256180 |
29 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.98730627 |
30 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.94384899 |
31 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.93280488 |
32 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.90709354 |
33 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.88510687 |
34 | MYB_26560356_Chip-Seq_TH1_Human | 1.77062692 |
35 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.75114307 |
36 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.73105681 |
37 | UTX_26944678_Chip-Seq_JUKART_Human | 1.70089062 |
38 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.64635823 |
39 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.61091118 |
40 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.52899466 |
41 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.51025831 |
42 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.49826298 |
43 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.49477014 |
44 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.48303195 |
45 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.47657398 |
46 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.43104233 |
47 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.42679976 |
48 | GATA1_22025678_ChIP-Seq_K562_Human | 1.42461913 |
49 | MAF_26560356_Chip-Seq_TH2_Human | 1.39846787 |
50 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.39686420 |
51 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.37945704 |
52 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.34627957 |
53 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.34159433 |
54 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.32032067 |
55 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.31880217 |
56 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.31098327 |
57 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.30356774 |
58 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.29404400 |
59 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.28949822 |
60 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.25824162 |
61 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.24505192 |
62 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.23051404 |
63 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.22584467 |
64 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.22328467 |
65 | * CIITA_25753668_ChIP-Seq_RAJI_Human | 1.22039371 |
66 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.21025371 |
67 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.20572609 |
68 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.18618916 |
69 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.16888582 |
70 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.16097240 |
71 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.16078277 |
72 | GATA3_26560356_Chip-Seq_TH2_Human | 1.15846768 |
73 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.15169539 |
74 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.15022602 |
75 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.13563095 |
76 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.13496019 |
77 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.12109974 |
78 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.10056226 |
79 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.09879450 |
80 | GATA1_19941826_ChIP-Seq_K562_Human | 1.07412418 |
81 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.04999888 |
82 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.03182510 |
83 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.01334322 |
84 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.99375061 |
85 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.98822206 |
86 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.97306477 |
87 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.96737092 |
88 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.91412167 |
89 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.89458183 |
90 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.88726790 |
91 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.88245385 |
92 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.88063896 |
93 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.87834575 |
94 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.83569266 |
95 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 0.83517057 |
96 | P300_27268052_Chip-Seq_Bcells_Human | 0.82617669 |
97 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.82442002 |
98 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.80340719 |
99 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.77191150 |
100 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.76385447 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0001835_abnormal_antigen_presentation | 4.42275197 |
2 | MP0003303_peritoneal_inflammation | 3.80869396 |
3 | MP0005671_abnormal_response_to | 3.59472521 |
4 | MP0003436_decreased_susceptibility_to | 3.45408462 |
5 | MP0001790_abnormal_immune_system | 3.31515315 |
6 | MP0005387_immune_system_phenotype | 3.31515315 |
7 | MP0003724_increased_susceptibility_to | 3.26073093 |
8 | MP0000685_abnormal_immune_system | 3.14147038 |
9 | MP0002148_abnormal_hypersensitivity_rea | 3.08278365 |
10 | MP0001800_abnormal_humoral_immune | 3.04861554 |
11 | MP0005000_abnormal_immune_tolerance | 3.03061616 |
12 | MP0009785_altered_susceptibility_to | 2.93349877 |
13 | MP0005025_abnormal_response_to | 2.81493465 |
14 | MP0002419_abnormal_innate_immunity | 2.78900423 |
15 | MP0002452_abnormal_antigen_presenting | 2.71969309 |
16 | MP0006082_CNS_inflammation | 2.71950287 |
17 | MP0002723_abnormal_immune_serum | 2.61908270 |
18 | MP0005058_abnormal_lysosome_morphology | 2.45876403 |
19 | MP0002420_abnormal_adaptive_immunity | 2.39774151 |
20 | MP0001819_abnormal_immune_cell | 2.38010586 |
21 | MP0010155_abnormal_intestine_physiology | 2.21382984 |
22 | MP0003300_gastrointestinal_ulcer | 2.10548489 |
23 | MP0009840_abnormal_foam_cell | 2.00393477 |
24 | MP0003172_abnormal_lysosome_physiology | 1.98342137 |
25 | MP0002138_abnormal_hepatobiliary_system | 1.95538343 |
26 | MP0001845_abnormal_inflammatory_respons | 1.91919257 |
27 | MP0003191_abnormal_cellular_cholesterol | 1.90088239 |
28 | MP0005464_abnormal_platelet_physiology | 1.86020064 |
29 | MP0003183_abnormal_peptide_metabolism | 1.84752849 |
30 | MP0002139_abnormal_hepatobiliary_system | 1.83171176 |
31 | MP0001533_abnormal_skeleton_physiology | 1.82908313 |
32 | MP0000716_abnormal_immune_system | 1.80857986 |
33 | MP0002405_respiratory_system_inflammati | 1.74791067 |
34 | MP0003763_abnormal_thymus_physiology | 1.71771144 |
35 | MP0002398_abnormal_bone_marrow | 1.70735506 |
36 | MP0004947_skin_inflammation | 1.70696174 |
37 | MP0009764_decreased_sensitivity_to | 1.66422340 |
38 | MP0003075_altered_response_to | 1.66015694 |
39 | MP0009333_abnormal_splenocyte_physiolog | 1.62355115 |
40 | MP0008469_abnormal_protein_level | 1.60406268 |
41 | MP0005310_abnormal_salivary_gland | 1.52146226 |
42 | MP0001853_heart_inflammation | 1.51567380 |
43 | MP0003806_abnormal_nucleotide_metabolis | 1.48356928 |
44 | MP0009278_abnormal_bone_marrow | 1.47468302 |
45 | MP0005166_decreased_susceptibility_to | 1.46736941 |
46 | MP0000689_abnormal_spleen_morphology | 1.45652008 |
47 | MP0002429_abnormal_blood_cell | 1.43201270 |
48 | MP0002166_altered_tumor_susceptibility | 1.41925819 |
49 | MP0000343_altered_response_to | 1.41076808 |
50 | MP0000604_amyloidosis | 1.40419737 |
51 | MP0005451_abnormal_body_composition | 1.33123341 |
52 | MP0005397_hematopoietic_system_phenotyp | 1.32550450 |
53 | MP0001545_abnormal_hematopoietic_system | 1.32550450 |
54 | MP0002998_abnormal_bone_remodeling | 1.32141868 |
55 | MP0000465_gastrointestinal_hemorrhage | 1.31431314 |
56 | MP0002722_abnormal_immune_system | 1.30695699 |
57 | MP0003866_abnormal_defecation | 1.26275351 |
58 | MP0000858_altered_metastatic_potential | 1.22474518 |
59 | MP0001873_stomach_inflammation | 1.19562400 |
60 | MP0004510_myositis | 1.17920448 |
61 | MP0008004_abnormal_stomach_pH | 1.07850646 |
62 | MP0003448_altered_tumor_morphology | 1.05441890 |
63 | MP0008260_abnormal_autophagy | 1.05057159 |
64 | MP0003828_pulmonary_edema | 1.02350669 |
65 | MP0002006_tumorigenesis | 1.00812920 |
66 | MP0001663_abnormal_digestive_system | 0.97842678 |
67 | MP0003690_abnormal_glial_cell | 0.96055638 |
68 | MP0009763_increased_sensitivity_to | 0.92144849 |
69 | MP0000490_abnormal_crypts_of | 0.86299721 |
70 | MP0000703_abnormal_thymus_morphology | 0.82318608 |
71 | MP0005360_urolithiasis | 0.81272535 |
72 | MP0000249_abnormal_blood_vessel | 0.80969526 |
73 | MP0005167_abnormal_blood-brain_barrier | 0.80081367 |
74 | MP0001851_eye_inflammation | 0.78704003 |
75 | MP0005165_increased_susceptibility_to | 0.77800438 |
76 | MP0004883_abnormal_blood_vessel | 0.75781758 |
77 | MP0005365_abnormal_bile_salt | 0.74690023 |
78 | MP0005390_skeleton_phenotype | 0.72509610 |
79 | MP0002933_joint_inflammation | 0.72167418 |
80 | MP0002132_abnormal_respiratory_system | 0.72028970 |
81 | MP0002396_abnormal_hematopoietic_system | 0.71645408 |
82 | MP0005164_abnormal_response_to | 0.70688218 |
83 | MP0002136_abnormal_kidney_physiology | 0.65377264 |
84 | MP0009765_abnormal_xenobiotic_induced | 0.65054705 |
85 | MP0000015_abnormal_ear_pigmentation | 0.63828946 |
86 | MP0009643_abnormal_urine_homeostasis | 0.63795422 |
87 | MP0003453_abnormal_keratinocyte_physiol | 0.63738010 |
88 | MP0000920_abnormal_myelination | 0.63359039 |
89 | MP0003795_abnormal_bone_structure | 0.61651866 |
90 | MP0008874_decreased_physiological_sensi | 0.60305330 |
91 | MP0003045_fibrosis | 0.60301068 |
92 | MP0002277_abnormal_respiratory_mucosa | 0.59969568 |
93 | MP0003091_abnormal_cell_migration | 0.59895856 |
94 | MP0004808_abnormal_hematopoietic_stem | 0.59601188 |
95 | MP0000609_abnormal_liver_physiology | 0.59377329 |
96 | MP0005319_abnormal_enzyme/_coenzyme | 0.58724371 |
97 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.58568565 |
98 | MP0005381_digestive/alimentary_phenotyp | 0.57611319 |
99 | MP0003656_abnormal_erythrocyte_physiolo | 0.55957196 |
100 | MP0002254_reproductive_system_inflammat | 0.55382632 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Eczematoid dermatitis (HP:0000976) | 5.11484517 |
2 | Recurrent bacterial skin infections (HP:0005406) | 5.05630115 |
3 | Recurrent abscess formation (HP:0002722) | 4.86193624 |
4 | Abnormality of macrophages (HP:0004311) | 4.84755223 |
5 | Abnormality of glycolipid metabolism (HP:0010969) | 4.61859070 |
6 | Abnormality of liposaccharide metabolism (HP:0010968) | 4.61859070 |
7 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 4.61859070 |
8 | Systemic lupus erythematosus (HP:0002725) | 4.58878123 |
9 | Agammaglobulinemia (HP:0004432) | 4.14521610 |
10 | * Meningitis (HP:0001287) | 3.91907220 |
11 | Myositis (HP:0100614) | 3.80351271 |
12 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.79441415 |
13 | Vasculitis (HP:0002633) | 3.78904819 |
14 | Chronic obstructive pulmonary disease (HP:0006510) | 3.73496241 |
15 | Obstructive lung disease (HP:0006536) | 3.73496241 |
16 | Gastrointestinal stroma tumor (HP:0100723) | 3.66210953 |
17 | Recurrent fungal infections (HP:0002841) | 3.66047216 |
18 | * Mediastinal lymphadenopathy (HP:0100721) | 3.64424117 |
19 | Increased cerebral lipofuscin (HP:0011813) | 3.62405639 |
20 | Vacuolated lymphocytes (HP:0001922) | 3.61311475 |
21 | Orchitis (HP:0100796) | 3.59107578 |
22 | Recurrent skin infections (HP:0001581) | 3.56242116 |
23 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.52161573 |
24 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.48741217 |
25 | Recurrent cutaneous fungal infections (HP:0011370) | 3.48741217 |
26 | Optic neuritis (HP:0100653) | 3.43882825 |
27 | Retrobulbar optic neuritis (HP:0100654) | 3.43882825 |
28 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.40500213 |
29 | Recurrent viral infections (HP:0004429) | 3.36866775 |
30 | Cellulitis (HP:0100658) | 3.30890179 |
31 | Colitis (HP:0002583) | 3.24163424 |
32 | Recurrent sinusitis (HP:0011108) | 3.13456697 |
33 | Dysostosis multiplex (HP:0000943) | 3.09692242 |
34 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 3.03262533 |
35 | Stomatitis (HP:0010280) | 3.01381584 |
36 | Panhypogammaglobulinemia (HP:0003139) | 3.00668658 |
37 | * Pulmonary infiltrates (HP:0002113) | 3.00472602 |
38 | Hemoptysis (HP:0002105) | 2.99600290 |
39 | Encephalitis (HP:0002383) | 2.99181832 |
40 | Loss of speech (HP:0002371) | 2.98704228 |
41 | Recurrent bronchitis (HP:0002837) | 2.96601144 |
42 | Increased IgE level (HP:0003212) | 2.91052911 |
43 | Autoimmune thrombocytopenia (HP:0001973) | 2.88778868 |
44 | Inflammation of the large intestine (HP:0002037) | 2.85164385 |
45 | Abnormality of the prostate (HP:0008775) | 2.84207110 |
46 | Restrictive lung disease (HP:0002091) | 2.82359097 |
47 | * Urticaria (HP:0001025) | 2.79068605 |
48 | Spontaneous hematomas (HP:0007420) | 2.76401358 |
49 | Chest pain (HP:0100749) | 2.74973726 |
50 | Gastrointestinal inflammation (HP:0004386) | 2.74780959 |
51 | Gastrointestinal infarctions (HP:0005244) | 2.72486953 |
52 | Gingivitis (HP:0000230) | 2.71606619 |
53 | Osteomyelitis (HP:0002754) | 2.67035431 |
54 | Glomerulonephritis (HP:0000099) | 2.66960412 |
55 | Chronic diarrhea (HP:0002028) | 2.65774017 |
56 | Increased IgM level (HP:0003496) | 2.65693552 |
57 | Recurrent pneumonia (HP:0006532) | 2.62547710 |
58 | Lymphopenia (HP:0001888) | 2.58486397 |
59 | Pustule (HP:0200039) | 2.57834277 |
60 | Purpura (HP:0000979) | 2.51351581 |
61 | Disinhibition (HP:0000734) | 2.49938748 |
62 | Keratoconjunctivitis sicca (HP:0001097) | 2.47893192 |
63 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.46484000 |
64 | Chronic otitis media (HP:0000389) | 2.46451945 |
65 | Recurrent lower respiratory tract infections (HP:0002783) | 2.44029580 |
66 | Petechiae (HP:0000967) | 2.42571958 |
67 | Malnutrition (HP:0004395) | 2.41833067 |
68 | Hypergammaglobulinemia (HP:0010702) | 2.41633652 |
69 | IgM deficiency (HP:0002850) | 2.41556522 |
70 | Skin rash (HP:0000988) | 2.38730134 |
71 | Emphysema (HP:0002097) | 2.35201344 |
72 | Gangrene (HP:0100758) | 2.33345305 |
73 | Amyloidosis (HP:0011034) | 2.30875498 |
74 | Abnormality of T cells (HP:0002843) | 2.30121015 |
75 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.28531024 |
76 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.28531024 |
77 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.28531024 |
78 | Keratoconjunctivitis (HP:0001096) | 2.26985908 |
79 | Abnormality of T cell number (HP:0011839) | 2.26472022 |
80 | Pulmonary embolism (HP:0002204) | 2.25540012 |
81 | Abnormality of T cell physiology (HP:0011840) | 2.25441709 |
82 | Premature loss of primary teeth (HP:0006323) | 2.24702435 |
83 | Hepatosplenomegaly (HP:0001433) | 2.22512318 |
84 | T lymphocytopenia (HP:0005403) | 2.22466664 |
85 | Mucopolysacchariduria (HP:0008155) | 2.19801970 |
86 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.19801970 |
87 | IgA deficiency (HP:0002720) | 2.18067771 |
88 | Increased serum ferritin (HP:0003281) | 2.16677975 |
89 | Epistaxis (HP:0000421) | 2.16165227 |
90 | Polyneuropathy (HP:0001271) | 2.14710968 |
91 | Sepsis (HP:0100806) | 2.13141927 |
92 | Abnormality of B cell number (HP:0010975) | 2.12472326 |
93 | Mutism (HP:0002300) | 2.12324862 |
94 | Abnormality of the nasal mucosa (HP:0000433) | 2.10751939 |
95 | * Abnormality of the pleura (HP:0002103) | 2.10502549 |
96 | Arterial thrombosis (HP:0004420) | 2.08927830 |
97 | Complement deficiency (HP:0004431) | 2.06935420 |
98 | Verrucae (HP:0200043) | 2.06701062 |
99 | Papilloma (HP:0012740) | 2.06701062 |
100 | Autoimmune hemolytic anemia (HP:0001890) | 2.06594373 |
Rank | Gene Set | Z-score |
---|---|---|
1 | RIPK4 | 4.30980946 |
2 | MAP4K1 | 4.18664381 |
3 | BLK | 3.70415386 |
4 | ERN1 | 3.41667471 |
5 | TYK2 | 3.08439396 |
6 | MAP3K14 | 2.83293458 |
7 | TBK1 | 2.57612682 |
8 | IRAK4 | 2.40300489 |
9 | PRPF4B | 2.36150868 |
10 | KIT | 2.34334509 |
11 | CSF1R | 2.23512377 |
12 | SYK | 2.20168266 |
13 | IKBKE | 2.14182677 |
14 | JAK3 | 2.06554384 |
15 | CSK | 2.01956366 |
16 | BMPR2 | 2.00462290 |
17 | MAP3K13 | 1.88916096 |
18 | FES | 1.85211795 |
19 | IKBKB | 1.83416025 |
20 | BTK | 1.81104556 |
21 | TXK | 1.66186768 |
22 | MATK | 1.64464381 |
23 | LYN | 1.63979567 |
24 | ZAP70 | 1.62222529 |
25 | NME2 | 1.59700846 |
26 | JAK1 | 1.57310685 |
27 | IRAK3 | 1.50289413 |
28 | MAP2K3 | 1.46870620 |
29 | FGR | 1.41944086 |
30 | MAP3K11 | 1.39127571 |
31 | TAOK3 | 1.31844913 |
32 | GRK7 | 1.30427902 |
33 | HCK | 1.25754807 |
34 | TESK2 | 1.23495913 |
35 | TNK2 | 1.20472829 |
36 | SIK3 | 1.20268049 |
37 | LCK | 1.19683121 |
38 | MAP3K3 | 1.19312429 |
39 | CDC42BPA | 1.15448169 |
40 | ITK | 1.11121132 |
41 | JAK2 | 1.10325324 |
42 | TEC | 1.09995493 |
43 | GRK6 | 1.04936387 |
44 | TAOK2 | 1.02820624 |
45 | TGFBR2 | 0.98996861 |
46 | MAP3K1 | 0.94505624 |
47 | PRKCQ | 0.82452008 |
48 | ACVR1B | 0.80426684 |
49 | TAOK1 | 0.79781709 |
50 | KDR | 0.77535700 |
51 | SMG1 | 0.76843082 |
52 | CHUK | 0.76380170 |
53 | DDR2 | 0.74831516 |
54 | PDK1 | 0.74327936 |
55 | STK10 | 0.73863821 |
56 | SIK2 | 0.72083431 |
57 | FGFR4 | 0.71855084 |
58 | MARK3 | 0.70313302 |
59 | RIPK1 | 0.69783773 |
60 | NEK9 | 0.64633305 |
61 | PIM2 | 0.62766528 |
62 | CDK19 | 0.62395034 |
63 | PDPK1 | 0.62251916 |
64 | MAPK7 | 0.61976060 |
65 | MAPK12 | 0.60281880 |
66 | IRAK1 | 0.59425833 |
67 | PIM1 | 0.58577757 |
68 | MAPK11 | 0.58271408 |
69 | TLK1 | 0.53489630 |
70 | FGFR3 | 0.53405353 |
71 | FYN | 0.52217129 |
72 | EPHB1 | 0.51642446 |
73 | BCKDK | 0.50621410 |
74 | ABL1 | 0.48557886 |
75 | LRRK2 | 0.47158329 |
76 | HIPK2 | 0.46629042 |
77 | ARAF | 0.46565252 |
78 | MAP3K5 | 0.46452242 |
79 | MOS | 0.45803978 |
80 | CDK6 | 0.44650432 |
81 | PIK3CG | 0.42835093 |
82 | MAPKAPK2 | 0.42398970 |
83 | CDK4 | 0.41665506 |
84 | PRKCD | 0.41076642 |
85 | IRAK2 | 0.39105809 |
86 | RPS6KL1 | 0.39052202 |
87 | RPS6KC1 | 0.39052202 |
88 | MAPK4 | 0.37646845 |
89 | MAP2K6 | 0.37163052 |
90 | ADRBK2 | 0.34755530 |
91 | STK24 | 0.33435237 |
92 | EPHA3 | 0.32082447 |
93 | DAPK3 | 0.31358137 |
94 | RPS6KA6 | 0.30446778 |
95 | ABL2 | 0.29178465 |
96 | PRKG2 | 0.29006916 |
97 | MAP2K2 | 0.28292437 |
98 | MAP3K8 | 0.27520031 |
99 | EGFR | 0.27192782 |
100 | TRIB3 | 0.25452888 |
Rank | Gene Set | Z-score |
---|---|---|
1 | * Asthma_Homo sapiens_hsa05310 | 4.54274258 |
2 | * Allograft rejection_Homo sapiens_hsa05330 | 4.53033309 |
3 | * Autoimmune thyroid disease_Homo sapiens_hsa05320 | 4.18011371 |
4 | * Graft-versus-host disease_Homo sapiens_hsa05332 | 4.17151737 |
5 | * Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 3.86294055 |
6 | * Staphylococcus aureus infection_Homo sapiens_hsa05150 | 3.65383688 |
7 | * Type I diabetes mellitus_Homo sapiens_hsa04940 | 3.47063808 |
8 | * Leishmaniasis_Homo sapiens_hsa05140 | 3.10453894 |
9 | * Antigen processing and presentation_Homo sapiens_hsa04612 | 2.81087382 |
10 | * Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.77087346 |
11 | * Viral myocarditis_Homo sapiens_hsa05416 | 2.53354232 |
12 | * Rheumatoid arthritis_Homo sapiens_hsa05323 | 2.25687477 |
13 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.19463593 |
14 | * Tuberculosis_Homo sapiens_hsa05152 | 2.00800602 |
15 | Other glycan degradation_Homo sapiens_hsa00511 | 1.96261116 |
16 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.89995127 |
17 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.77930266 |
18 | * Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.71568289 |
19 | * Toxoplasmosis_Homo sapiens_hsa05145 | 1.70248025 |
20 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.65464596 |
21 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.60629159 |
22 | * Influenza A_Homo sapiens_hsa05164 | 1.60556909 |
23 | * Herpes simplex infection_Homo sapiens_hsa05168 | 1.50490021 |
24 | * Phagosome_Homo sapiens_hsa04145 | 1.45815486 |
25 | * Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.43531234 |
26 | Lysosome_Homo sapiens_hsa04142 | 1.42326992 |
27 | Pertussis_Homo sapiens_hsa05133 | 1.22761791 |
28 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.12100954 |
29 | * Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.08589008 |
30 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.06712645 |
31 | Measles_Homo sapiens_hsa05162 | 1.05724077 |
32 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.04590188 |
33 | Malaria_Homo sapiens_hsa05144 | 1.01863338 |
34 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.01673352 |
35 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.95927240 |
36 | Legionellosis_Homo sapiens_hsa05134 | 0.95855861 |
37 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.91763933 |
38 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.90349622 |
39 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.88207749 |
40 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.80281425 |
41 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.79911612 |
42 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.79602560 |
43 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.78067189 |
44 | Salmonella infection_Homo sapiens_hsa05132 | 0.77222675 |
45 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.75999073 |
46 | * Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.75089893 |
47 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.73303790 |
48 | Hepatitis C_Homo sapiens_hsa05160 | 0.71985923 |
49 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.71002174 |
50 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.68566981 |
51 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.62975444 |
52 | Apoptosis_Homo sapiens_hsa04210 | 0.61934207 |
53 | Hepatitis B_Homo sapiens_hsa05161 | 0.61011269 |
54 | Shigellosis_Homo sapiens_hsa05131 | 0.60436608 |
55 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.52130375 |
56 | * HTLV-I infection_Homo sapiens_hsa05166 | 0.51522257 |
57 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.46974816 |
58 | Platelet activation_Homo sapiens_hsa04611 | 0.44205737 |
59 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.41704915 |
60 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.40646089 |
61 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.39825389 |
62 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.38784038 |
63 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.35769853 |
64 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.33575507 |
65 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.29247980 |
66 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.27098635 |
67 | Galactose metabolism_Homo sapiens_hsa00052 | 0.26442692 |
68 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.26388572 |
69 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.26047575 |
70 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.25331806 |
71 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.25303384 |
72 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.24504303 |
73 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.23263195 |
74 | Amoebiasis_Homo sapiens_hsa05146 | 0.22824467 |
75 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.22562425 |
76 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.22069410 |
77 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.21946826 |
78 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.19146647 |
79 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.18746647 |
80 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.18194284 |
81 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.17963572 |
82 | Prion diseases_Homo sapiens_hsa05020 | 0.17409811 |
83 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.17274162 |
84 | Mineral absorption_Homo sapiens_hsa04978 | 0.16932671 |
85 | Endocytosis_Homo sapiens_hsa04144 | 0.16876249 |
86 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.16017779 |
87 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.14039723 |
88 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.13032454 |
89 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.12723941 |
90 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.12486099 |
91 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.10045464 |
92 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.08457613 |
93 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.08070374 |
94 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.07714029 |
95 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.07482281 |
96 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.07257234 |
97 | Insulin resistance_Homo sapiens_hsa04931 | 0.06732288 |
98 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.06234478 |
99 | Bladder cancer_Homo sapiens_hsa05219 | 0.05814553 |
100 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.04704068 |