HLA-DRB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)9.90233102
2B cell mediated immunity (GO:0019724)7.76035319
3regulation of antigen processing and presentation of peptide antigen (GO:0002583)7.48587153
4positive thymic T cell selection (GO:0045059)7.06832508
5chaperone mediated protein folding requiring cofactor (GO:0051085)7.06728891
6regulation of antigen processing and presentation (GO:0002577)6.14225792
7positive regulation of antigen processing and presentation (GO:0002579)5.72465313
8interferon-gamma-mediated signaling pathway (GO:0060333)5.69992769
9antigen processing and presentation of endogenous antigen (GO:0019883)5.38199098
10positive T cell selection (GO:0043368)5.05156084
11DNA deamination (GO:0045006)4.90658828
12L-fucose catabolic process (GO:0042355)4.86955756
13fucose catabolic process (GO:0019317)4.86955756
14L-fucose metabolic process (GO:0042354)4.86955756
15T-helper 1 type immune response (GO:0042088)4.63008438
16regulation of dendritic cell antigen processing and presentation (GO:0002604)4.47202262
17production of molecular mediator of immune response (GO:0002440)4.40817662
18negative regulation of inflammatory response to antigenic stimulus (GO:0002862)4.36437803
19regulation of B cell apoptotic process (GO:0002902)4.29589052
20regulation of interferon-alpha production (GO:0032647)4.25764628
21T cell costimulation (GO:0031295)4.25270405
22regulation of interferon-beta biosynthetic process (GO:0045357)4.23969566
23cellular response to interferon-gamma (GO:0071346)4.21123605
24lymphocyte costimulation (GO:0031294)4.19504497
25positive regulation of interferon-alpha production (GO:0032727)4.19256619
26negative regulation of B cell apoptotic process (GO:0002903)4.15541157
27positive regulation of type 2 immune response (GO:0002830)3.96873453
28positive regulation of macrophage cytokine production (GO:0060907)3.91587229
29negative regulation of mast cell activation (GO:0033004)3.85197293
30response to interferon-gamma (GO:0034341)3.83733087
31detection of bacterium (GO:0016045)3.81233768
32regulation of B cell receptor signaling pathway (GO:0050855)3.66400809
33response to interferon-beta (GO:0035456)3.61302297
34positive regulation of interferon-beta production (GO:0032728)3.58935385
35detection of other organism (GO:0098543)3.46147789
36regulation of mast cell activation (GO:0033003)3.37242406
37B cell receptor signaling pathway (GO:0050853)3.36715819
38negative thymic T cell selection (GO:0045060)3.36579275
39positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.32826549
40mast cell degranulation (GO:0043303)3.31850694
41mast cell activation involved in immune response (GO:0002279)3.31850694
42growth hormone receptor signaling pathway (GO:0060396)3.29523687
43antigen receptor-mediated signaling pathway (GO:0050851)3.28939989
44regulation of inflammatory response to antigenic stimulus (GO:0002861)3.28342635
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.22139826
46adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.20538144
47response to host immune response (GO:0052572)3.19235185
48response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.19235185
49antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002503.15270225
50antigen processing and presentation of peptide antigen via MHC class II (GO:0002495)3.15270225
51thymic T cell selection (GO:0045061)3.13961333
52lymphocyte mediated immunity (GO:0002449)3.13648111
53mast cell activation (GO:0045576)3.13007960
54antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)3.11045422
55positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.10248240
56positive regulation of T-helper 1 type immune response (GO:0002827)3.10247338
57negative T cell selection (GO:0043383)3.03247032
58microglial cell activation (GO:0001774)3.02170123
59antigen processing and presentation via MHC class Ib (GO:0002475)3.01657598
60platelet dense granule organization (GO:0060155)2.96710962
61T cell receptor signaling pathway (GO:0050852)2.94768284
62positive regulation of mast cell activation involved in immune response (GO:0033008)2.94748819
63positive regulation of mast cell degranulation (GO:0043306)2.94748819
64tyrosine phosphorylation of STAT protein (GO:0007260)2.94651962
65regulation of interferon-beta production (GO:0032648)2.92947232
66modulation by symbiont of host defense response (GO:0052031)2.92273392
67modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.92273392
68modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.92273392
69positive regulation by organism of defense response of other organism involved in symbiotic interact2.92273392
70modulation by symbiont of host immune response (GO:0052553)2.92273392
71positive regulation by symbiont of host defense response (GO:0052509)2.92273392
72cellular response to growth hormone stimulus (GO:0071378)2.92232870
73regulation of macrophage cytokine production (GO:0010935)2.91338775
74response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.91037951
75response to host (GO:0075136)2.91037951
76response to host defenses (GO:0052200)2.91037951
77fusion of sperm to egg plasma membrane (GO:0007342)2.89417019
78positive regulation of prostaglandin secretion (GO:0032308)2.88611885
79purine deoxyribonucleotide catabolic process (GO:0009155)2.86821454
80tryptophan metabolic process (GO:0006568)2.84901793
81positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.84886428
82regulation of T-helper 1 cell differentiation (GO:0045625)2.84843324
83purinergic nucleotide receptor signaling pathway (GO:0035590)2.84542369
84positive regulation of mast cell activation (GO:0033005)2.81711542
85myeloid cell activation involved in immune response (GO:0002275)2.81497077
86T cell selection (GO:0045058)2.79298230
87monoamine transport (GO:0015844)2.78670507
88plasma membrane fusion (GO:0045026)2.78120272
89positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.76602835
90positive regulation of response to cytokine stimulus (GO:0060760)2.76066865
91positive regulation of chemokine production (GO:0032722)2.74315213
92thrombin receptor signaling pathway (GO:0070493)2.73638105
93adaptive immune response (GO:0002250)2.71098652
94positive regulation of T cell activation (GO:0050870)2.70705544
95positive regulation of interferon-gamma production (GO:0032729)2.67863391
96positive regulation of neutrophil chemotaxis (GO:0090023)2.67462672
97positive regulation of neutrophil migration (GO:1902624)2.67462672
98response to peptidoglycan (GO:0032494)2.66182630
99leukocyte mediated immunity (GO:0002443)2.65821702
100macrophage activation involved in immune response (GO:0002281)2.65344048

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.90554685
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.97770230
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.79855681
4CIITA_25753668_ChIP-Seq_RAJI_Human3.66002901
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.43618384
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.25641494
7ZNF274_21170338_ChIP-Seq_K562_Hela2.80739191
8IGF1R_20145208_ChIP-Seq_DFB_Human2.24566601
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.22338697
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.21207686
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.20053317
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07347287
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.87832900
14GATA3_26560356_Chip-Seq_TH2_Human1.86212916
15EGR1_23403033_ChIP-Seq_LIVER_Mouse1.85366374
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75525483
17LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.73846145
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61279476
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61133447
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.61000264
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57861968
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57817242
23SCL_19346495_ChIP-Seq_HPC-7_Human1.57780511
24TAF2_19829295_ChIP-Seq_ESCs_Human1.57009467
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56156655
26SPI1_23547873_ChIP-Seq_NB4_Human1.55742234
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.55493694
28VDR_22108803_ChIP-Seq_LS180_Human1.52845659
29AUTS2_25519132_ChIP-Seq_293T-REX_Human1.52204410
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.51568749
31LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51457870
32VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.50566904
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50179485
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.50067016
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49319540
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48592558
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47623068
38GATA3_21878914_ChIP-Seq_MCF-7_Human1.43936444
39FOXA1_21572438_ChIP-Seq_LNCaP_Human1.41534002
40MYB_26560356_Chip-Seq_TH2_Human1.41377741
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40557590
42AR_20517297_ChIP-Seq_VCAP_Human1.40196026
43IRF1_19129219_ChIP-ChIP_H3396_Human1.39864330
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.36618474
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34844549
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.32959788
47GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32933295
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32589971
49TP53_22573176_ChIP-Seq_HFKS_Human1.32225444
50ER_23166858_ChIP-Seq_MCF-7_Human1.30287187
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27735895
52P300_27268052_Chip-Seq_Bcells_Human1.26143497
53GATA3_27048872_Chip-Seq_THYMUS_Human1.24180033
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23382849
55FOXA1_25329375_ChIP-Seq_VCAP_Human1.23382849
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22360263
57BCL6_27268052_Chip-Seq_Bcells_Human1.19523812
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.18427272
59BCAT_22108803_ChIP-Seq_LS180_Human1.17340224
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15185458
61GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.13766379
62ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13626005
63VDR_23849224_ChIP-Seq_CD4+_Human1.13254997
64RUNX_20019798_ChIP-Seq_JUKART_Human1.12934713
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12819353
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06326838
67E2F1_20622854_ChIP-Seq_HELA_Human1.05834473
68FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05702507
69TDRD3_21172665_ChIP-Seq_MCF-7_Human1.05552711
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04549896
71TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04484138
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04242468
73CBP_20019798_ChIP-Seq_JUKART_Human1.04242468
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03192609
75EWS_26573619_Chip-Seq_HEK293_Human1.02111270
76SPI1_20517297_ChIP-Seq_HL60_Human1.01124254
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99328684
78CEBPB_22108803_ChIP-Seq_LS180_Human0.97536466
79ELF1_20517297_ChIP-Seq_JURKAT_Human0.97464252
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97179270
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96762544
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96755688
83NANOG_19829295_ChIP-Seq_ESCs_Human0.96298737
84SOX2_19829295_ChIP-Seq_ESCs_Human0.96298737
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.95199951
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94920941
87NANOG_20526341_ChIP-Seq_ESCs_Human0.94450695
88MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94038292
89STAT1_20625510_ChIP-Seq_HELA_Human0.93581177
90FOXH1_21741376_ChIP-Seq_EPCs_Human0.93077803
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93057810
92FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92846957
93MYB_26560356_Chip-Seq_TH1_Human0.92834451
94FOXP3_21729870_ChIP-Seq_TREG_Human0.92804747
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92171883
96GATA3_26560356_Chip-Seq_TH1_Human0.91094907
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90934001
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90323901
99MYC_19829295_ChIP-Seq_ESCs_Human0.90202816
100EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89826829

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system7.36247824
2MP0001835_abnormal_antigen_presentation5.24004858
3MP0003724_increased_susceptibility_to3.64513995
4MP0003303_peritoneal_inflammation3.44410164
5MP0001800_abnormal_humoral_immune2.90692207
6MP0005671_abnormal_response_to2.88436374
7MP0002139_abnormal_hepatobiliary_system2.74210177
8MP0005000_abnormal_immune_tolerance2.41324123
9MP0003806_abnormal_nucleotide_metabolis2.36587453
10MP0000685_abnormal_immune_system2.36053496
11MP0005167_abnormal_blood-brain_barrier2.34793723
12MP0002148_abnormal_hypersensitivity_rea2.31606603
13MP0002452_abnormal_antigen_presenting2.28570337
14MP0001790_abnormal_immune_system2.21791407
15MP0005387_immune_system_phenotype2.21791407
16MP0005084_abnormal_gallbladder_morpholo2.20840839
17MP0002723_abnormal_immune_serum2.18728476
18MP0002420_abnormal_adaptive_immunity1.92916430
19MP0001819_abnormal_immune_cell1.90402818
20MP0002166_altered_tumor_susceptibility1.82443879
21MP0003183_abnormal_peptide_metabolism1.80993930
22MP0009785_altered_susceptibility_to1.76638606
23MP0008872_abnormal_physiological_respon1.73850812
24MP0005646_abnormal_pituitary_gland1.65841000
25MP0002419_abnormal_innate_immunity1.65378129
26MP0010155_abnormal_intestine_physiology1.48327306
27MP0005085_abnormal_gallbladder_physiolo1.47825760
28MP0005025_abnormal_response_to1.46715144
29MP0000716_abnormal_immune_system1.44985266
30MP0002398_abnormal_bone_marrow1.40871899
31MP0002006_tumorigenesis1.38851058
32MP0005464_abnormal_platelet_physiology1.37930591
33MP0009764_decreased_sensitivity_to1.36555988
34MP0003045_fibrosis1.35876182
35MP0001663_abnormal_digestive_system1.34025776
36MP0009278_abnormal_bone_marrow1.30763043
37MP0001845_abnormal_inflammatory_respons1.28347916
38MP0003436_decreased_susceptibility_to1.25496663
39MP0001501_abnormal_sleep_pattern1.23176734
40MP0000569_abnormal_digit_pigmentation1.22349132
41MP0008875_abnormal_xenobiotic_pharmacok1.20315411
42MP0000465_gastrointestinal_hemorrhage1.19351749
43MP0000689_abnormal_spleen_morphology1.17933276
44MP0002429_abnormal_blood_cell1.17883250
45MP0001545_abnormal_hematopoietic_system1.15511842
46MP0005397_hematopoietic_system_phenotyp1.15511842
47MP0003786_premature_aging1.15158469
48MP0000613_abnormal_salivary_gland1.15060431
49MP0005410_abnormal_fertilization1.14926608
50MP0003252_abnormal_bile_duct1.14099330
51MP0001533_abnormal_skeleton_physiology1.14050928
52MP0008469_abnormal_protein_level1.12408102
53MP0001873_stomach_inflammation1.11623875
54MP0003075_altered_response_to1.09343279
55MP0000230_abnormal_systemic_arterial1.07174256
56MP0008775_abnormal_heart_ventricle1.05221661
57MP0005365_abnormal_bile_salt1.03798646
58MP0005360_urolithiasis1.02826008
59MP0003172_abnormal_lysosome_physiology1.00054804
60MP0002876_abnormal_thyroid_physiology0.98099894
61MP0001968_abnormal_touch/_nociception0.97681909
62MP0005166_decreased_susceptibility_to0.97185761
63MP0010368_abnormal_lymphatic_system0.93682834
64MP0004808_abnormal_hematopoietic_stem0.92942793
65MP0005595_abnormal_vascular_smooth0.92475582
66MP0003866_abnormal_defecation0.90004772
67MP0005645_abnormal_hypothalamus_physiol0.89654999
68MP0002405_respiratory_system_inflammati0.88546548
69MP0001764_abnormal_homeostasis0.87044971
70MP0009780_abnormal_chondrocyte_physiolo0.86781501
71MP0004782_abnormal_surfactant_physiolog0.86750891
72MP0002928_abnormal_bile_duct0.85649904
73MP0003191_abnormal_cellular_cholesterol0.84025258
74MP0005058_abnormal_lysosome_morphology0.83355838
75MP0006054_spinal_hemorrhage0.83343344
76MP0006292_abnormal_olfactory_placode0.82025788
77MP0008877_abnormal_DNA_methylation0.81014848
78MP0001986_abnormal_taste_sensitivity0.79607993
79MP0002638_abnormal_pupillary_reflex0.79470892
80MP0003195_calcinosis0.79322892
81MP0002722_abnormal_immune_system0.76715191
82MP0005381_digestive/alimentary_phenotyp0.74797098
83MP0003646_muscle_fatigue0.74361341
84MP0002102_abnormal_ear_morphology0.74184952
85MP0003763_abnormal_thymus_physiology0.72264788
86MP0005075_abnormal_melanosome_morpholog0.71505538
87MP0008995_early_reproductive_senescence0.71431939
88MP0004147_increased_porphyrin_level0.70364069
89MP0005165_increased_susceptibility_to0.67802358
90MP0002282_abnormal_trachea_morphology0.67611420
91MP0009643_abnormal_urine_homeostasis0.66284969
92MP0005310_abnormal_salivary_gland0.65315757
93MP0006082_CNS_inflammation0.63344847
94MP0004084_abnormal_cardiac_muscle0.61303034
95MP0004145_abnormal_muscle_electrophysio0.61101238
96MP0005319_abnormal_enzyme/_coenzyme0.60810516
97MP0000249_abnormal_blood_vessel0.60184628
98MP0003828_pulmonary_edema0.60136529
99MP0005551_abnormal_eye_electrophysiolog0.56646271
100MP0005220_abnormal_exocrine_pancreas0.55725043

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)5.62992098
2Abnormality of the prostate (HP:0008775)4.64203802
3Meningitis (HP:0001287)3.95717578
4Abnormal delayed hypersensitivity skin test (HP:0002963)3.80723175
5Panhypogammaglobulinemia (HP:0003139)3.74604376
6Visual hallucinations (HP:0002367)3.63238156
7Chronic mucocutaneous candidiasis (HP:0002728)3.45430191
8Recurrent cutaneous fungal infections (HP:0011370)3.45430191
9Hypoproteinemia (HP:0003075)3.44167335
10Mediastinal lymphadenopathy (HP:0100721)3.37843728
11Pulmonary infiltrates (HP:0002113)3.34352459
12Vasculitis (HP:0002633)3.31283953
13Abolished electroretinogram (ERG) (HP:0000550)3.26051898
14Hypomagnesemia (HP:0002917)3.15707193
15Pulmonary fibrosis (HP:0002206)3.11134445
16Abnormality of B cell number (HP:0010975)3.09606818
17Testicular atrophy (HP:0000029)3.08959356
18Prostate neoplasm (HP:0100787)2.99551256
19Focal motor seizures (HP:0011153)2.98728668
20Increased neuronal autofluorescent lipopigment (HP:0002074)2.97536200
21Recurrent bronchitis (HP:0002837)2.95520625
22Type II lissencephaly (HP:0007260)2.80090571
23Recurrent fungal infections (HP:0002841)2.79923787
24Stomach cancer (HP:0012126)2.78235458
25Urticaria (HP:0001025)2.75631016
26Dyschromatopsia (HP:0007641)2.71484909
27Abnormality of male internal genitalia (HP:0000022)2.66904473
28Xerostomia (HP:0000217)2.60465162
29Abnormality of the pleura (HP:0002103)2.58278591
30Increased cerebral lipofuscin (HP:0011813)2.57810876
31Ureteral stenosis (HP:0000071)2.57155488
32Recurrent bacterial skin infections (HP:0005406)2.53210373
33IgG deficiency (HP:0004315)2.51699052
34Gastrointestinal stroma tumor (HP:0100723)2.50397382
35Elevated erythrocyte sedimentation rate (HP:0003565)2.49640147
36Hemoptysis (HP:0002105)2.49392993
37Chronic obstructive pulmonary disease (HP:0006510)2.48675981
38Obstructive lung disease (HP:0006536)2.48675981
39Abnormality of magnesium homeostasis (HP:0004921)2.42324540
403-Methylglutaconic aciduria (HP:0003535)2.41863205
41Ureteral obstruction (HP:0006000)2.41656861
42Colitis (HP:0002583)2.41166632
43Chest pain (HP:0100749)2.39121902
44Recurrent abscess formation (HP:0002722)2.37753044
45Encephalitis (HP:0002383)2.35790577
46Retinal dysplasia (HP:0007973)2.33651346
47Attenuation of retinal blood vessels (HP:0007843)2.29803321
48Recurrent skin infections (HP:0001581)2.29163679
49Cellulitis (HP:0100658)2.26784867
50Restrictive lung disease (HP:0002091)2.22391763
51Chronic sinusitis (HP:0011109)2.22254906
52Congenital stationary night blindness (HP:0007642)2.21955692
53Fair hair (HP:0002286)2.21786924
54Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.20111110
55Recurrent pneumonia (HP:0006532)2.16204338
56Abnormality of T cell physiology (HP:0011840)2.10515272
57Metabolic alkalosis (HP:0200114)2.08496451
58Recurrent viral infections (HP:0004429)2.08294665
59Pustule (HP:0200039)2.06183710
60Skin rash (HP:0000988)2.04859626
61Progressive neurologic deterioration (HP:0002344)2.03724936
62Recurrent lower respiratory tract infections (HP:0002783)2.00981815
63Retrobulbar optic neuritis (HP:0100654)2.00038498
64Optic neuritis (HP:0100653)2.00038498
65Delayed CNS myelination (HP:0002188)1.98433481
66Pulmonary embolism (HP:0002204)1.98030826
67Gangrene (HP:0100758)1.96356338
68Osteomyelitis (HP:0002754)1.94892022
69Alveolar cell carcinoma (HP:0006519)1.93750289
70Amelogenesis imperfecta (HP:0000705)1.91868053
71Inflammation of the large intestine (HP:0002037)1.91406807
72Calf muscle hypertrophy (HP:0008981)1.90743122
73Abnormality of glycolipid metabolism (HP:0010969)1.89898129
74Abnormality of liposaccharide metabolism (HP:0010968)1.89898129
75Abnormality of glycosphingolipid metabolism (HP:0004343)1.89898129
76Verrucae (HP:0200043)1.89443908
77Papilloma (HP:0012740)1.89443908
78Clumsiness (HP:0002312)1.88996723
79Type 2 muscle fiber atrophy (HP:0003554)1.87898499
80Abnormal biliary tract physiology (HP:0012439)1.86959178
81Bile duct proliferation (HP:0001408)1.86959178
82B lymphocytopenia (HP:0010976)1.86119834
83Alkalosis (HP:0001948)1.85820926
84Myositis (HP:0100614)1.85789014
85Increased corneal curvature (HP:0100692)1.85555187
86Keratoconus (HP:0000563)1.85555187
87Disproportionate short-trunk short stature (HP:0003521)1.83772044
88Hematochezia (HP:0002573)1.83690329
89J-shaped sella turcica (HP:0002680)1.83302964
90Abnormality of the peritoneum (HP:0002585)1.82262577
91Abnormality of T cells (HP:0002843)1.82202866
92Polygenic inheritance (HP:0010982)1.81305021
93Arterial thrombosis (HP:0004420)1.80360042
94Hypothermia (HP:0002045)1.80130218
95Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79793584
96Carpal bone hypoplasia (HP:0001498)1.79577955
97Concave nail (HP:0001598)1.79103221
98Hypertensive crisis (HP:0100735)1.78548322
99Polyuria (HP:0000103)1.77810799
100Muscle hypertrophy of the lower extremities (HP:0008968)1.76613292

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.59898015
2BMPR1B4.22872766
3FRK3.57017145
4KIT3.46858577
5TLK13.39836838
6CDK193.01666676
7EIF2AK32.78923946
8GRK12.64046702
9CDK82.36940523
10MAP4K12.32198878
11PINK12.22732256
12FES2.10597124
13TEC2.09793417
14SYK2.05733659
15SCYL22.03053632
16TAOK32.02040245
17BMPR22.00502585
18TGFBR11.97221693
19CSF1R1.74087860
20ZAK1.71172944
21OXSR11.63856908
22MAP4K21.63428559
23IRAK41.54861980
24FER1.54143679
25KDR1.52372139
26IKBKE1.51912347
27MAPKAPK31.50324463
28NUAK11.40698983
29VRK21.38512809
30ITK1.38378655
31RIPK41.33720556
32ADRBK21.32790592
33ACVR1B1.30740936
34LYN1.26748731
35JAK31.24857626
36MST41.23988251
37BCKDK1.23417395
38EIF2AK21.16186242
39PHKG21.13956290
40PHKG11.13956290
41MAP2K61.10757982
42TBK11.08013624
43FLT31.06538668
44BTK1.00141296
45SIK30.89741211
46GRK70.89242836
47PIK3CG0.87026411
48CDK90.84523537
49ADRBK10.83215367
50BLK0.78627511
51MAP2K10.73357046
52IKBKB0.72162104
53FGFR20.71750070
54MAP3K140.67811358
55LCK0.67682021
56INSRR0.66663757
57ERBB30.65310937
58ZAP700.64644056
59ABL10.59209001
60GRK50.59159114
61TXK0.58154562
62MATK0.57985428
63CHUK0.57227467
64CSNK1G30.56723725
65PRKCI0.55765965
66PLK20.53566380
67HCK0.53069154
68GRK60.52900801
69MAPKAPK50.51986286
70MAP2K30.50283737
71DAPK20.45972022
72ERN10.45676099
73STK390.45311612
74MAP2K20.45087889
75CAMKK10.41857699
76PRKCQ0.41614933
77TNK20.40075455
78VRK10.38401985
79CSK0.38085350
80PLK30.35441419
81PIK3CA0.35297097
82MAPK130.34818806
83PTK2B0.34782290
84PDK10.34279413
85IGF1R0.33880960
86RPS6KA50.32648249
87EGFR0.31427058
88WNK40.30178071
89TRIM280.28885094
90CSNK1G10.27746716
91TYK20.27026870
92CSNK1A1L0.26366726
93CSNK1G20.23535563
94PRKCA0.23279226
95MAP3K50.22959719
96TAF10.22950338
97PRKCD0.22924648
98CAMKK20.22579337
99MAPK30.22188914
100TRPM70.19843236

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053106.47529838
2Allograft rejection_Homo sapiens_hsa053305.41908688
3Intestinal immune network for IgA production_Homo sapiens_hsa046725.15196770
4Autoimmune thyroid disease_Homo sapiens_hsa053205.12796887
5Graft-versus-host disease_Homo sapiens_hsa053325.04040517
6Type I diabetes mellitus_Homo sapiens_hsa049404.40479871
7Staphylococcus aureus infection_Homo sapiens_hsa051503.46125173
8Antigen processing and presentation_Homo sapiens_hsa046123.20376174
9Viral myocarditis_Homo sapiens_hsa054162.94803717
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.89657403
11Leishmaniasis_Homo sapiens_hsa051402.81858392
12Rheumatoid arthritis_Homo sapiens_hsa053232.46475162
13Systemic lupus erythematosus_Homo sapiens_hsa053221.61491113
14Hematopoietic cell lineage_Homo sapiens_hsa046401.60651678
15Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.53626083
16Tuberculosis_Homo sapiens_hsa051521.42598647
17Toxoplasmosis_Homo sapiens_hsa051451.38989021
18Herpes simplex infection_Homo sapiens_hsa051681.30355040
19Primary immunodeficiency_Homo sapiens_hsa053401.16639005
20Influenza A_Homo sapiens_hsa051641.15287934
21Phagosome_Homo sapiens_hsa041451.05796481
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82173282
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77497955
24Linoleic acid metabolism_Homo sapiens_hsa005910.76264899
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72341891
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67815126
27Sulfur metabolism_Homo sapiens_hsa009200.64438362
28Nitrogen metabolism_Homo sapiens_hsa009100.64403753
29Proteasome_Homo sapiens_hsa030500.61769816
30Phototransduction_Homo sapiens_hsa047440.61237322
31Selenocompound metabolism_Homo sapiens_hsa004500.55062035
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54794906
33Arachidonic acid metabolism_Homo sapiens_hsa005900.51640689
34B cell receptor signaling pathway_Homo sapiens_hsa046620.47230343
35NF-kappa B signaling pathway_Homo sapiens_hsa040640.47188723
36NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46039629
37Ether lipid metabolism_Homo sapiens_hsa005650.45945446
38Epstein-Barr virus infection_Homo sapiens_hsa051690.45935847
39HTLV-I infection_Homo sapiens_hsa051660.43588160
40Other glycan degradation_Homo sapiens_hsa005110.42875852
41Legionellosis_Homo sapiens_hsa051340.40531340
42SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38988653
43Tryptophan metabolism_Homo sapiens_hsa003800.38343475
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35214647
45Lysosome_Homo sapiens_hsa041420.33448228
46Fat digestion and absorption_Homo sapiens_hsa049750.33447126
47Pertussis_Homo sapiens_hsa051330.27140150
48ABC transporters_Homo sapiens_hsa020100.25565050
49Olfactory transduction_Homo sapiens_hsa047400.23917711
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23839781
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23556299
52RNA degradation_Homo sapiens_hsa030180.23470184
53Caffeine metabolism_Homo sapiens_hsa002320.22875073
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.22163081
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20658070
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.20559779
57Basal transcription factors_Homo sapiens_hsa030220.19899211
58Peroxisome_Homo sapiens_hsa041460.19821027
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.18719039
60Pentose phosphate pathway_Homo sapiens_hsa000300.17524646
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.17191052
62Oxidative phosphorylation_Homo sapiens_hsa001900.16783951
63Homologous recombination_Homo sapiens_hsa034400.16621734
64Osteoclast differentiation_Homo sapiens_hsa043800.14511992
65Regulation of autophagy_Homo sapiens_hsa041400.13659945
66Salivary secretion_Homo sapiens_hsa049700.13478431
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.13186744
68Collecting duct acid secretion_Homo sapiens_hsa049660.12116447
69Platelet activation_Homo sapiens_hsa046110.12100245
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.11899350
71Measles_Homo sapiens_hsa051620.11380131
72RNA polymerase_Homo sapiens_hsa030200.10132324
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.09316111
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.09299192
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.08481606
76Chemical carcinogenesis_Homo sapiens_hsa052040.08309458
77Pyrimidine metabolism_Homo sapiens_hsa002400.07013450
78Parkinsons disease_Homo sapiens_hsa050120.06691211
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.05481552
80Purine metabolism_Homo sapiens_hsa002300.04490147
81Hepatitis C_Homo sapiens_hsa051600.04300389
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.03888571
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.03674237
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.03423342
85Mismatch repair_Homo sapiens_hsa034300.03221787
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.02205178
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.01546644
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.00981157
89Taurine and hypotaurine metabolism_Homo sapiens_hsa00430-0.0440855
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0405153
91Fatty acid elongation_Homo sapiens_hsa00062-0.0362495
92beta-Alanine metabolism_Homo sapiens_hsa00410-0.0322516
93Calcium signaling pathway_Homo sapiens_hsa04020-0.0313231
94Histidine metabolism_Homo sapiens_hsa00340-0.0289165
95Base excision repair_Homo sapiens_hsa03410-0.0236135
96Retinol metabolism_Homo sapiens_hsa00830-0.0154781
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980-0.0071733
98Drug metabolism - cytochrome P450_Homo sapiens_hsa00982-0.0024532
99Fanconi anemia pathway_Homo sapiens_hsa03460-0.0012335
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0006484

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